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Bile duct injury

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https://www.readbyqxmd.com/read/29352225/a-humanized-mouse-model-of-liver-fibrosis-following-expansion-of-transplanted-hepatic-stellate-cells
#1
Daniel Benten, Johannes Kluwe, Jan W Wirth, Nina D Thiele, Antonia Follenzi, Kuldeep K Bhargava, Christopher J Palestro, Michael Koepke, Reni Tjandra, Tassilo Volz, Marc Lutgehetmann, Sanjeev Gupta
Hepatic stellate cells (HSCs) are major contributors to liver fibrosis, as hepatic injuries may cause their transdifferentiation into myofibroblast-like cells capable of producing excessive extracellular matrix proteins. Also, HSCs can modulate engraftment of transplanted hepatocytes and contribute to liver regeneration. Therefore, understanding the biology of human HSCs (hHSCs) is important, but effective methods have not been available to address their fate in vivo. To investigate whether HSCs could engraft and repopulate the liver, we transplanted GFP-transduced immortalized hHSCs into immunodeficient NOD/SCID mice...
January 19, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29351939/retroperitoneal-bile-leak-after-laparoscopic-cholecystectomy
#2
Dee Zhen Lim, Enoch Wong, Sayed Hassen, Yahya Al-Habbal
Bile duct injury (BDI) is a well-recognised complication of laparoscopic cholecystectomy (LC). Following a BDI, bile usually leaks into the peritoneal space and causes biliary peritonitis. This manifests as non-specific abdominal pain and fever occurring several days after the surgery. It can be managed by laparoscopic washout with or without bile duct repair. We present a rare case of retroperitoneal bile leak post-LC. The mechanism of injury here was likely partial avulsion from excessive traction of the cystic duct during intraoperative cholangiogram...
January 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29351705/percutaneous-endoscopic-rendezvous-procedure-for-the-management-of-bile-duct-injuries-after-cholecystectomy-short-and-long-term-outcomes
#3
Anne Marthe Schreuder, Klaske A C Booij, Philip R de Reuver, Otto M van Delden, Krijn P van Lienden, Marc G Besselink, Olivier R Busch, Dirk J Gouma, Erik A J Rauws, Thomas M van Gulik
BACKGROUND:  Bile duct injury (BDI) remains a daunting complication of laparoscopic cholecystectomy. In patients with complex BDI, a percutaneous-endoscopic rendezvous procedure may be required to establish bile duct continuity. The aim of this study was to assess short- and long-term outcomes of the rendezvous procedure. METHODS:  All consecutive patients with BDI referred to our tertiary referral center between 1995 and 2016 were analyzed. A rendezvous procedure was performed when endoscopic or radiologic intervention failed, and when deemed feasible by a dedicated multidisciplinary team including hepatopancreaticobiliary surgeons, gastrointestinal endoscopists, and interventional radiologists...
January 19, 2018: Endoscopy
https://www.readbyqxmd.com/read/29345755/expression-of-hepatic-progenitor-cell-markers-in-acute-cellular-rejection-of-liver-allografts-an-immunohistochemical-study
#4
Regina Cheuk-Lam Lo, Kristy Kwan-Shuen Chan, Carmen Oi-Ning Leung, Irene Oi-Lin Ng
BACKGROUND: Hepatic progenitor cells (HPC) are induced following liver injury to facilitate regeneration. Acute cellular rejection (ACR) is a common complication after liver transplantation as a result of immune-mediated liver injury. In this study we characterized HPC phenotype in liver allograft biopsy with ACR. We also explored the correlation between expression HPC immunophenotype and clinicopathological parameters. METHODS: Forty-four liver allograft biopsies performed between 2008-2016 in a single center with histologically proven ACR were examined for immunohistochemical expression of HPC markers CK19 and Sox9...
January 18, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29343773/mitochondrial-mutations-in-cholestatic-liver-disease-with-biliary-atresia
#5
Hong Koh, Gun-Seok Park, Sun-Mi Shin, Chang Eon Park, Seung Kim, Seok Joo Han, Huy Quang Pham, Jae-Ho Shin, Dong-Woo Lee
Biliary atresia (BA) results in severe bile blockage and is caused by the absence of extrahepatic ducts. Even after successful hepatic portoenterostomy, a considerable number of patients are likely to show progressive deterioration in liver function. Recent studies show that mutations in protein-coding mitochondrial DNA (mtDNA) genes and/or mitochondrial genes in nuclear DNA (nDNA) are associated with hepatocellular dysfunction. This observation led us to investigate whether hepatic dysfunctions in BA is genetically associated with mtDNA mutations...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29339113/development-of-the-liver-insights-into-organ-and-tissue-morphogenesis
#6
REVIEW
Elke A Ober, Frédéric P Lemaigre
Recent development of improved tools and methods to analyze tissues at the three-dimensional level has expanded our capacity to investigate morphogenesis of foetal liver. Here, we review the key morphogenetic steps during liver development, from the prehepatic endoderm stage to the postnatal period, and consider several model organisms while focusing on mammalian liver. We first discuss how the liver buds out of the endoderm and gives rise to an asymmetric liver. We next outline the mechanisms driving liver and lobe growth, and review morphogenesis of the intra- and extrahepatic bile ducts; morphogenetic responses of the biliary tract to liver injury are discussed...
January 12, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29330836/pathogenesis-of-non-alcoholic-fatty-liver-disease-mediated-by-yap
#7
Ping Chen, Qihui Luo, Chao Huang, Qi Gao, Like Li, Jingfei Chen, Bing Chen, Wentao Liu, Wen Zeng, Zhengli Chen
OBJECTIVE: This study aimed to investigate the mechanism of the interaction between Yes-associated protein (YAP) and transforming growth factor-β (TGF-β)/Smad signaling pathways in the development of non-alcoholic fatty liver disease (NAFLD). METHODS: Serum samples of monkeys with biopsy-proven NAFLD and healthy normal monkeys were used to measure fasting plasma glucose (FPG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG) and albumin (ALB) with the BECKMAN CX5 PRO...
January 12, 2018: Hepatology International
https://www.readbyqxmd.com/read/29328070/nerve-growth-factor-upregulates-sirtuin-1-expression-in-cholestasis-a-potential-therapeutic-target
#8
Ming-Shian Tsai, Po-Huang Lee, Cheuk-Kwan Sun, Ting-Chia Chiu, Yu-Chun Lin, I-Wei Chang, Po-Han Chen, Ying-Hsien Kao
This study investigated the regulatory role of nerve growth factor (NGF) in sirtuin 1 (SIRT1) expression in cholestatic livers. We evaluated the expression of NGF and its cognate receptors in human livers with hepatolithiasis and the effects of NGF therapy on liver injury and hepatic SIRT1 expression in a bile duct ligation (BDL) mouse model. Histopathological and molecular analyses showed that the hepatocytes of human diseased livers expressed NGF, proNGF (a precursor of NGF), TrkA and p75NTR, whereas only p75NTR was upregulated in hepatolithiasis, compared with non-hepatolithiasis livers...
January 12, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29319016/analysis-of-post-operative-complication-in-single-port-laparoscopic-cholecystectomy-a-retrospective-analysis-in-817-cases-from-a-surgeon
#9
Yongmin Lee, Younghoon Roh, Minchan Kim, Younghoon Kim, Kwanwoo Kim, Sunghwa Kang, Eunjeong Jang
BACKGROUND: Single-port laparoscopic cholecystectomy (SPLC) is a new advanced technique in laparoscopic surgery which has many benefits according to previous reports. The purpose of this study was to present personal experiences with SPLC in> 800 cases performed by a surgeon to evaluate the safety and feasibility of this procedure. MATERIALS AND METHODS: A retrospective review of 817 cases of SPLC was conducted. All patients had received elective SPLC by a surgeon in our centre during March 2009-August 2015...
January 10, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29313126/an-observational-study-of-the-timing-of-surgery-use-of-laparoscopy-and-outcomes-for-acute-cholecystitis-in-the-usa-and-uk
#10
A C Murray, S Markar, H Mackenzie, O Baser, T Wiggins, A Askari, G Hanna, O Faiz, E Mayer, C Bicknell, A Darzi, R P Kiran
BACKGROUND: Evidence supports early laparoscopic cholecystectomy for acute cholecystitis. Differences in treatment patterns between the USA and UK, associated outcomes and resource utilization are not well understood. METHODS: In this retrospective, observational study using national administrative data, emergency patients admitted with acute cholecystitis were identified in England (Hospital Episode Statistics 1998-2012) and USA (National Inpatient Sample 1998-2011)...
January 8, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29312539/regulatory-t-cells-with-a-defect-in-inhibition-on-co-stimulation-deteriorated-primary-biliary-cholangitis
#11
Jianing Chen, Xianliang Hou, Hongyu Jia, Guangying Cui, Zhongwen Wu, Lin Wang, Chong Lu, Wei Wu, Yingfeng Wei, Toshimitsu Uede, Lanjuan Li, Zhexiong Lian, Hongyan Diao
Regulatory T cells (Tregs) play an indispensable role in the progression of primary biliary cholangitis (PBC). Although Tregs could normalize costimulation in in vivo and in vitro models, it is obscure whether and how Tregs mediate these effects in PBC. Herein we focused on the quantitative and functional characteristics of Tregs in PBC. The number and proportion of Tregs, and the production of interleukin (IL)-10 were all significantly less in the PBC patients than in the healthy controls (HCs). In addition, compared to the HCs, the costimulatory CD86 of the circulation and liver were significantly higher in the patients with PBC...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29311000/biliary-repair-after-main-bile-duct-injury-in-a-patient-with-fusion-of-hepatic-planes-anatomical-variation-with-video
#12
D Dousse, P Otal, B Suc
No abstract text is available yet for this article.
January 5, 2018: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29307716/how-to-manage-bile-duct-injury-in-patients-with-duodenal-switch
#13
Elias Chahine, Radwan Kassir, Elie Chouillard
No abstract text is available yet for this article.
November 28, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29307612/diminished-survival-in-patients-with-bile-leaks-and-ductal-injuries-management-strategy-influences-outcomes
#14
Zhi Ven Fong, Henry A Pitt, Steven M Strasberg, Andrew P Loehrer, Jason K Sicklick, Mark A Talamini, Keith D Lillemoe, David C Chang
BACKGROUND: The increased incidence of bile duct injuries (BDI) following the adoption of laparoscopic cholecystectomy has been well documented. However, the longitudinal impact of bile leaks and BDIs on survival and health care utilization have not been adequately studied. The aims of this analysis were to determine the incidence, long-term outcomes and costs of bile leaks and ductal injuries in a large population. STUDY DESIGN: The California Office of Statewide Health Planning and Development database was queried from 2005-14...
January 4, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29307496/dithiothreitol-supplementation-mitigates-hepatic-and-renal-injury-in-bile-duct-ligated-mice-potential-application-in-the-treatment-of-cholestasis-associated-complications
#15
Reza Heidari, Vahid Ghanbarinejad, Hamidreza Mohammadi, Asrin Ahmadi, Athena Esfandiari, Negar Azarpira, Hossein Niknahad
Cholestasis is a disorder characterized by impaired bile flow and accumulation of cytotoxic bile acids in the liver. On the other hand, oxidative stress and its deleterious consequences seem to have a significant role in cholestasis-induced organ injury. Hence, antioxidants and thiol-reducing agents could have potential protective effect against this complication. The current investigation was designed to evaluate the effect of dithiothreitol (DTT) as a safe and clinically applicable thiol-reductant in cholestatic animals...
January 4, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29288124/adult-hepatocytes-direct-liver-organogenesis-through-non-parenchymal-cell-recruitment-in-the-kidney
#16
Rie Utoh, Junji Komori, Hiroyuki Kuge, Kohei Tatsumi, Masumi Yamada, Shinji Hirohashi, Masahiro Tsutsumi, Toshihiro Amanuma, Akira Yoshioka, Yoshiyuki Nakajima, Kenjiro Wake, Teruo Okano, Eric Lagasse, Kazuo Ohashi
BACKGROUND & AIMS: Since the first account of the myth of Prometheus, the amazing regenerative capacity of the liver has fascinated researchers due to its enormous medical potential. Liver regeneration is promoted by multiple types of liver cells, including hepatocytes and liver non-parenchymal cells (NPCs), through the complex intercellular signaling. However, the liver organogenetic mechanism, especially the role of adult hepatocytes at ectopic sites, remains unknown. In this study, we demonstrate that hepatocytes alone spurred liver organogenesis to form an organ-sized complex 3D liver that exhibited native liver architecture and functions in the kidneys of mice...
December 26, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29281894/adeno-associated-virus-2-aav2-mediated-reintroduction-of-microrna-19b-attenuates-hepatic-fibrosis
#17
Elizabeth Brandon-Warner, Jennifer H Benbow, Jacob H Swet, Nicole A Feilen, Catherine R Culberson, Iain H McKillop, Andrew S deLemos, Mark W Russo, Laura W Schrum
Fibrotic liver injury is a significant healthcare burden in the United States that represents a major cause of morbidity and mortality for which there are no effective FDA approved treatment strategies. Fibrosis is considered a disruption of normal wound healing responses mediated by fibroblastic cells which are triggered and sustained by pro-fibrotic cytokines such as transforming growth factor-beta1 (TGFβ1). TGFβ1-mediated transdifferentiation of hepatic stellate cells (HSCs) from quiescent to activated myofibroblast is a pivotal event in the development of fibrosis...
December 27, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/29280060/minimally-invasive-approach-robotic-and-laparoscopic-to-biliary-enteric-fistula-secondary-to-cholecystectomy-bile-duct-injury
#18
Adolfo Cuendis-Velázquez, Mario E Trejo-Ávila, Andrés Rodríguez-Parra, Orlando Bada-Yllán, Carlos Morales-Chávez, Luis Fernández-Álvarez, Eduardo Cárdenas-Lailson, Sujey Romero-Loera, Martin Rojano-Rodríguez, Mucio Moreno-Portillo
Spontaneous biliary-enteric fistula after laparoscopic cholecystectomy bile duct injury is an extremely rare entity. Y-en-Roux hepaticojejunostomy has been demonstrated to be an effective surgical technique to repair iatrogenic bile duct injuries. Seven consecutive patients underwent robotic-assisted (n = 5) and laparoscopic (n = 2) biliary-enteric fistula resection and bile duct repair at our hospital from January 2012 to May 2017. We reported our technique and described post-procedural outcomes. The mean age was 52...
December 26, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29273475/plectin-controls-biliary-tree-architecture-and-stability-in-cholestasis
#19
Marketa Jirouskova, Katerina Nepomucka, Gizem Oyman-Eyrilmez, Alzbeta Kalendova, Helena Havelkova, Lenka Sarnova, Karel Chalupsky, Bjoern Schuster, Oldrich Benada, Petra Miksatkova, Martin Kuchar, Ondrej Fabian, Radislav Sedlacek, Gerhard Wiche, Martin Gregor
BACKGROUND & AIMS: Plectin, a highly versatile cytolinker protein, controls intermediate filament (IF) cytoarchitecture and cellular stress response. In the present study, we investigate the role of plectin in the liver under basal conditions and in experimental cholestasis. METHODS: We generated liver-specific Plectin knockout (PleΔalb) mice and analyzed them using two cholestatic liver injury models: bile duct ligation (BDL) and 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) feeding...
December 19, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29250120/human-chorionic-plate-derived-mesenchymal-stem-cells-restore-hepatic-lipid-metabolism-in-a-rat-model-of-bile-duct-ligation
#20
Yun Bin Lee, Jong Ho Choi, Eun Nam Kim, Jin Seok, Hyun-Jung Lee, Jung-Hwan Yoon, Gi Jin Kim
In cholestatic liver diseases, impaired bile excretion disrupts lipid homeostasis. We investigated changes of lipid metabolism, including mitochondrial β-oxidation, in a rat model of bile duct ligation (BDL) in which chorionic plate-derived mesenchymal stem cells (CP-MSCs) were transplanted. Serum cholesterol level, which was elevated after BDL, was significantly decreased following CP-MSC transplantation. The expression levels of genes involved in intracellular lipid uptake, including long-chain fatty acyl-CoA synthetases and fatty acid transport proteins, were decreased in rats after BDL; however, they were not significantly changed by subsequent CP-MSC transplantation...
2017: Stem Cells International
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