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https://www.readbyqxmd.com/read/28749622/understanding-and-challenges-in-taking-tyrosine-kinase-inhibitors-among-malaysian-chronic-myeloid-leukemia-patients-a-qualitative-study
#1
Yik Ming Lim, Wei Lerk Eng, Huan Keat Chan
Background: In Malaysia, the treatment for chronic myeloid leukemia (CML) has long been delivered under the Malaysian Patient Assistance Program (MYPAP), but research on identifying factors contributing to non-adherence to tyrosine kinase inhibitors (TKIs) is still limited. The current study explored understanding and challenges of Malaysian CML patients in taking imatinib and nilotinib. Methods: Semi-structured, face-to-face interviews were conducted with 13 CML patients receiving treatment at a public tertiary care center, and were analyzed using the content analysis approach...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28748345/educational-inequality-in-cancer-mortality-a-record-linkage-study-of-over-35-million-italians
#2
Gianfranco Alicandro, Luisa Frova, Gabriella Sebastiani, Iman El Sayed, Paolo Boffetta, Carlo La Vecchia
PURPOSE: Large studies are needed to evaluate socioeconomic inequality for site-specific cancer mortality. We conducted a longitudinal census-based national study to quantify the relative inequality in cancer mortality among educational levels in Italy. METHODS: We linked the 2011 Italian census with the 2012 and 2013 death registries. Educational inequality in overall cancer and site-specific cancer mortality were evaluated by computing the mortality rate ratio (MRR)...
July 26, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28748255/cellular-and-subcellular-localization-of-adp-ribosylation-factor-6-in-mouse-peripheral-tissues
#3
Osamu Katsumata, Momoko Mori, Yusuke Sawane, Tomoko Niimura, Akiko Ito, Hirotsugu Okamoto, Masahiro Fukaya, Hiroyuki Sakagami
ADP-ribosylation factor 6 (Arf6) is a small GTPase that regulates endosomal trafficking and actin cytoskeleton remodeling. In the present study, we comprehensively examined the cellular and subcellular localization of Arf6 in adult mouse peripheral tissues by immunofluorescence and immunoelectron microscopy using the heat-induced antigen retrieval method with Tris-EDTA buffer (pH 9.0). Marked immunolabeling of Arf6 was observed particularly in epithelial cells of several tissues including the esophagus, stomach, small and large intestines, trachea, kidney, epididymis, oviduct, and uterus...
July 26, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28747950/pleural-empyema-caused-by-incarceration-and-perforation-of-the-stomach-wall-discovered-several-years-later-after-thoracic-trauma
#4
Szymon Smoliński, Mariusz Kasprzyk, Piotr Gabryel, Cezary Piwkowski
No abstract text is available yet for this article.
June 2017: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/28747330/effects-of-randomized-whey-protein-loads-on-energy-intake-appetite-gastric-emptying-and-plasma-gut-hormone-concentrations-in-older-men-and-women
#5
Caroline Giezenaar, Laurence G Trahair, Natalie D Luscombe-Marsh, Trygve Hausken, Scott Standfield, Karen L Jones, Kylie Lange, Michael Horowitz, Ian Chapman, Stijn Soenen
Background: Protein- and energy-rich supplements are used widely for the management of malnutrition in the elderly. Information about the effects of protein on energy intake and related gastrointestinal mechanisms and whether these differ between men and women is limited.Objective: We determined the effects of whey protein on energy intake, appetite, gastric emptying, and gut hormones in healthy older men and women.Design: Eight older women and 8 older men [mean ± SEM age: 72 ± 1 y; body mass index (in kg/m(2)): 25 ± 1] were studied on 3 occasions in which they received protein loads of 30 g (120 kcal) or 70 g (280 kcal) or a flavored water control drink (0 kcal)...
July 26, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28747054/towards-the-centralization-of-digestive-oncologic-surgery-changes-in-activity-techniques-and-outcome
#6
Cristian Tebé, Roger Pla, Josep Alfons Espinàs, Julieta Corral, Elisa Puigdomenech, Josep Maria Borràs, Joan M V Pons, Mireia Espallargues
The objective of the present study was to examine changes in the activity, surgical techniques and results from the process of centralization of complex digestive oncologic surgery in 2005-2012 as compared to 1996-2000. A retrospective cohort study employing the minimum basic data set of hospital discharge (MBDSHD 1996-2012) from public centers in Catalonia (Spain) was performed. The population consisted of individuals aged > 18 who underwent digestive oncologic surgery (esophagus, pancreas, liver, stomach or rectum)...
July 27, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28746484/obesity-and-orthodontic-treatment-is-there-any-direct-relationship
#7
Alberto Consolaro
Obesity is a wide-spread condition directly or indirectly connected with an increase in the prevalence of a variety of human diseases. It affects over 50% of the western overall population. In 2017, a thorough analysis of 204 studies on obesity and cancer revealed that the condition increases the risk of the following types of cancer: stomach, colon, rectal, bile duct, pancreatic, esophagus, breast, endometrial, ovarian, kidney and multiple myeloma. The first study aiming at establishing a connection between obesity and the rate of induced orthodontic tooth movement was conducted by Saloom et al; however, it could not effectively nor significantly reveal any direct influence or effect...
May 2017: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/28746451/histopathological-changes-induced-by-hysterothylacium-deardorffoverstreetorum-larvae-nematoda-raphidascarididae-in-priacanthus-arenatus-cuvier-1829-actinopterygii
#8
Bianca Porto Kuraiem, Marcelo Knoff, Nilza Nunes Felizardo, Rodrigo Caldas Menezes, Delir Corrêa Gomes, Sérgio Carmona de São Clemente
Priacanthus arenatus is a fish that occurs in the waters of the western Atlantic Ocean and has few records of parasitism. This study aimed to report histological changes caused by the larvae of Hysterothylacium deardorffoverstreetorum. Between July and December, 2013, 30 samples of P. arenatus were obtained from fish markets in the cities of Niterói and Rio de Janeiro, state of Rio de Janeiro, Brazil. Fragments of spleen, liver, stomach wall and mesentery tissues containing nodules and free parasites were extracted to histopathological study...
April 2017: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/28745303/extracellular-ph-monitoring-for-use-in-closed-loop-vagus-nerve-stimulation
#9
Simon C Cork, Amir Eftekhar, Khalid B Mirza, James V Gardiner, Stephen R Bloom, Christofer Toumazou
OBJECTIVE: Vagal nerve stimulation (VNS) has shown potential benefits for obesity treatment; however current devices lack physiological feedback, which limit their efficacy. Changes in extracellular pH (pH<sub>e</sub>) have shown to be correlated with neural activity, but have traditionally been measured with glass microelectrodes, which limit their in vivo applicability. APPROACH: Iridium oxide has previously been shown to be sensitive to fluctuations in pH and is biocompatible...
July 26, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28744106/evaluating-patient-preference-and-satisfaction-for-human-immunodeficiency-virus-therapy-in-france
#10
Sylvie Brégigeon-Ronot, Antoine Cheret, André Cabié, Thierry Prazuck, Alain Volny-Anne, Shehzad Ali, Catherine Bottomley, Laurent Finkielsztejn, Caroline Philippe, Jean-Jacques Parienti
OBJECTIVES: The objectives were 1) to elicit relative preferences for attributes of antiretroviral therapies (ART) in people living with HIV (PLWH) and 2) to explore satisfaction and adherence with current ART. PATIENTS AND METHODS: We conducted a multicenter cross-sectional study, consecutively enrolling PLWH receiving an ART. The quantitative part estimated the strength of preference for different attributes using an online discrete choice experiment (DCE). DCE data were analyzed using a mixed logit regression model...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28740967/incidental-gastrointestinal-stromal-tumor-at-a-gastroscopic-polypectomy-specimen-a-case-report-and-review-of-literature
#11
Dursun Özgür Karakaş, Özgür Dandin, Ahmet Ziya Balta, Yavuz Özdemir, İsmail Yılmaz, İlker Sücüllü
Although gastrointestinal stromal tumors (GISTs) comprise less than 1% of all gastrointestinal (GI) tract tumors, they are the most common mesenchymal tumors of the GI tract. Gastrointestinal stromal tumors can occur anywhere along the GI tract, but the stomach and small intestine are the most frequently involved sites. Gastrointestinal stromal tumors are frequently asymptomatic, and one-third of all cases are found incidentally. Endoscopy, endoscopic ultrasonography, and computed tomography are useful tools in the diagnosis...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28740664/development-of-a-novel-ex-vivo-porcine-laparoscopic-heller-myotomy-and-nissen-fundoplication-training-model-toronto-lap-nissen-simulator
#12
Hideki Ujiie, Tatsuya Kato, Hsin-Pei Hu, Patrycja Bauer, Priya Patel, Hironobu Wada, Daiyoon Lee, Kosuke Fujino, Colin Schieman, Andrew Pierre, Thomas K Waddell, Shaf Keshavjee, Gail E Darling, Kazuhiro Yasufuku
BACKGROUND: Surgical trainees are required to develop competency in a variety of laparoscopic operations. Developing laparoscopic technical skills can be difficult as there has been a decrease in the number of procedures performed. This study aims to develop an inexpensive and anatomically relevant model for training in laparoscopic foregut procedures. METHODS: An ex vivo, anatomic model of the human upper abdomen was developed using intact porcine esophagus, stomach, diaphragm and spleen...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28739754/collision-of-lymphoepithelioma-like-carcinoma-with-diffuse-large-b-cell-lymphoma-of-the-stomach-a-case-report
#13
Liyan Liu, Huishan Zhao, Lin Sheng, Ping Yang, Huihui Zhou, Ruizheng Wang
BACKGROUND/AIM: Collision of Epstein-Barr virus (EBV)-associated lymphoepithelioma-like carcinoma (LELC) with non-Hodgkin's lymphoma of the stomach is extremely rare. PATIENTS AND METHODS: Herein we report a case of LELC with primary diffuse large B-cell lymphoma (DLBCL) of the stomach in a 65-year-old patient. RESULTS: Gastric endoscopy showed a poorly differentiated adenocarcinoma of the stomach. The patient underwent radical gastrectomy, and histopathological examinations revealed the collision of LELC and DLBCL of the stomach...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739098/effects-of-bariatric-surgery-on-energy-homeostasis
#14
REVIEW
Wei Li, Denis Richard
Bariatric surgery represents the most efficient therapy for severe obesity. It reduces the size of fat stores or the amount of body fat gain. The bariatric surgery procedures currently used include Roux-en-Y gastric bypass and sleeve gastrectomy, which are the most commonly performed procedures. Other procedures are laparoscopic adjustable gastric banding and biliopancreatic diversion. The latter represents the most effective surgery for treatment of severe obesity as well as type 2 diabetes. Bariatric surgery reduces energy intake by restricting the size of the stomach reservoir and causing malabsorption, as in the case of biliopancreatic diversion...
August 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28738955/primary-site-predicts-grade-for-gastroenteropancreatic-neuroendocrine-tumors
#15
Timothy L Fitzgerald, Catalina Mosquera, C Suzanne Lea, Matthew McMullen
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare and abstruse neoplasms with increasing incidence and clinical relevance. The National Cancer Data Base was examined to identify GEP-NET cases from 2004 to 2013. In total, 39,454 patients diagnosed with GEP-NET were identified. Median age was 61 years. Majority was female (50.13%), white (79.49%), and had low-grade neoplasms (84.39%). On univariate analysis, age, sex, race, primary site, tumor size, and regional lymph node involvement were associated with tumor grade (P < 0...
July 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28738249/new-1-3-4-oxadiazole-oxime-hybrids-design-synthesis-anti-inflammatory-cox-inhibitory-activities-and-ulcerogenic-liability
#16
Heba S Abd-Ellah, Mohamed Abdel-Aziz, Mai E Shoman, Eman A M Beshr, TamerS Kaoud, Al-Shaimaa F F Ahmed
A series of new 1,3,4-oxadiazole/oxime hybrids were synthesized and designed as potent COX inhibitors. The prepared compounds were evaluated for their anti-inflammatory, antioxidant and ulcerogenic activities. The results indicated that the prepared compounds exhibited remarkable anti-inflammatory activity with (69.60-109.60% of indomethacin activity) after 4h. In vitro COX inhibitory assay showed that compounds 6d and 7h are potent COX inhibitors with IC50 of (1.10-0.94) and (2.30-5.00) µM on both COX-1 and COX-2 respectively...
June 15, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28738092/the-efficacy-of-jianpi-yiqi-therapy-for-chronic-atrophic-gastritis-a-systematic-review-and-meta-analysis
#17
Yun-Kai Dai, Yun-Zhan Zhang, Dan-Yan Li, Jin-Tong Ye, Ling-Feng Zeng, Qi Wang, Ling Hu
Jianpi Yiqi therapy (JYT) is a classical therapy in treating chronic atrophic gastritis (CAG), but the clinical effects of it are still contentious. The purpose of this article is to evaluate the efficacy and safety of JYT for CAG. Seven electronic databases including PubMed, Embase, Springer Link, CNKI (China National Knowledge Infrastructure), VIP (Chinese Scientific Journals Database), Wan-fang database, and CBM (Chinese Biomedicine Database) were searched from their inception to November 1, 2016. 13 randomized controlled trials (RCTs) with a total of 1119 participants were identified for analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28737477/changes-in-duodenal-enteroendocrine-cells-in-patients-with-irritable-bowel-syndrome-following-dietary-guidance
#18
Tarek Mazzawi, Magdy El-Salhy
The densities of enteroendocrine cells are abnormal in patients with irritable bowel syndrome (IBS); however, they tend to change toward normal levels in stomach, ileum, and colon following dietary guidance. The aim was to identify the types of duodenal enteroendocrine cells affected after receiving dietary guidance in the same group of patients with IBS. Fourteen patients with IBS and 14 control subjects were included. The patients received three sessions of dietary guidance. Both groups underwent gastroscopies at baseline, and again for the patients after 3-9 months (median, four months) from receiving dietary guidance...
July 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28737409/low-buffer-capacity-and-alternating-motility-along-the-human-gastrointestinal-tract-implications-for-in-vivo-dissolution-and-absorption-of-ionizable-drugs
#19
Bart Hens, Yasuhiro Tsume, Marival Bermejo, Paulo Paixao, Mark Koenigsknecht, Jason R Baker, William L Hasler, R Lionberger, Jianghong Fan, Joseph Dickens, Kerby A Shedden, Bo Wen, Jeffrey Wysocki, Raimar Löbenberg, Allen Lee, Ann F Fioritto, Gregory E Amidon, Alex Yu, Gail Benninghoff, Niloufar Salehi, Arjang Talattof, Duxin Sun, Gordon L Amidon
In this study, we determined the pH and buffer capacity of human gastrointestinal (GI) fluids (aspirated from the stomach, duodenum, proximal jejunum and mid/distal jejunum) as a function of time, from 37 healthy subjects after oral administration of an 800 mg immediate-release tablet of ibuprofen (reference listed drug; RLD) under typical prescribed bioequivalence (BE) study protocol conditions in both fasted and fed state (simulated by ingestion of a liquid meal). Simultaneously, motility was continuously monitored using water-perfused manometry...
July 24, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28737403/validation-of-dissolution-testing-with-biorelevant-media-an-orbito-study
#20
James Mann, Jennifer B Dressman, Karin Rosenblatt, Lee Ashworth, Uwe Muenster, Kerstin Frank, Paul Hutchins, James Williams, Lukas Klumpp, Kristina Wielockx, Philippe Berben, Patrick Augustijns, Rene Holm, Michael Hofmann, Sanjaykumar Patel, Stefania Beato, Krista Ojala, Irena Tomaszewska, Jean-Luc Bruel, James Butler
BACKGROUND: Dissolution testing with biorelevant media has become widespread in the pharmaceutical industry as a means of better understanding how drugs and formulations behave in the gastrointestinal tract. Until now, however, there have been few attempts to gauge the reproducibility of results obtained with these methods. PURPOSE: The aim of this study was to determine the inter-laboratory reproducibility of biorelevant dissolution testing, using the paddle apparatus (USP 2)...
July 24, 2017: Molecular Pharmaceutics
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