Simone Schüle, Felix Bunert, Carsten Hackenbroch, Meinrad Beer, Patrick Ostheim, Samantha Stewart, Matthias Port, Harry Scherthan, Michael Abend
After nuclear scenarios, combined injuries of acute radiation syndrome (ARS) with, e.g., abdominal trauma, will occur and may require contrast-enhanced computed tomography (CT) scans for diagnostic purposes. Here, we investigated the effect of iodinated contrast agents on radiation-induced gene expression (GE) changes used for biodosimetry (AEN, BAX, CDKN1A, EDA2R, APOBEC3H) and for hematologic ARS severity prediction (FDXR, DDB2, WNT3, POU2AF1), and on the induction of double-strand breaks (DSBs) used for biodosimetry...
January 29, 2024: Radiation Research