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JOURNAL ARTICLE
Mohamed-Ali Babi, Todd Raleigh, Robert E Shapiro, Joseph McSherry, Angela Applebee
No abstract text is available yet for this article.
October 14, 2014: Neurology
#22
Richard D Byrne, Selvaraju Veeriah, Christopher J Applebee, Banafshé Larijani
The fusogenic lipid diacylglycerol is essential for remodeling gamete and zygote nuclear envelopes (NE) during early embryogenesis. It is unclear whether upstream signaling molecules are likewise conserved. Here we demonstrate PLCγ and its activator SFK1, which co-operate during male pronuclear envelope formation, also promote the subsequent male and female pronuclear fusion. PLCγ and SFK1 interact directly at the fusion site leading to PLCγ activation. This is accompanied by a spatially restricted reduction of PtdIns(4,5)P 2...
August 11, 2014: Nucleus
#23
JOURNAL ARTICLE
Hrayr Attarian, Garrick Applebee, Angela Applebee, Bingxia Wang, Melissa Clark, Becky McCormick, Emma Salzman, Catherine Schuman
The prevalence of moderate-to-severe sleep problems is significantly higher among people with multiple sclerosis (MS) than in the general population. In 2002, we found a significant relationship between fatigue and disrupted sleep in patients with relapsing-remitting MS (RRMS). The objectives of this study were to determine whether eszopiclone (Lunesta; Sunovion Pharmaceuticals Inc, Marlborough, MA) was superior to placebo in improving sleep among patients with MS-related fatigue and sleep complaints (primary end point); and to assess the impact of improved sleep on daytime fatigue and functioning (secondary end point)...
2011: International Journal of MS Care
#24
REVIEW
Oana Dumitrascu, Carlos H Schenck, Garrick Applebee, Hrayr Attarian
BACKGROUND: Parasomnia overlap disorder (POD) currently is classified by the International Classification of Sleep Disorders, Second Edition (ICSD-2) as a variant of rapid eye movement (REM) sleep behavior disorder (RBD), and therefore its diagnosis also implies counseling the patients on the increased risk for developing neurodegenerative disorders. POD pathophysiology is not clear to date. METHODS: The authors report 5 cases of POD, review the literature, and analyze previously published cases of POD...
November 2013: Sleep Medicine
#25
JOURNAL ARTICLE
Jacky Davis, Ian Banks, David Wrigley, Clive Peedell, Alyson Pollock, Klim McPherson, Martin McKee, William L Irving, Peter Crome, Trisha Greenhalgh, Walter Holland, David Evans, Alan Maryon-Davis, Alan Smyth, Peter Fleming, Michel Coleman, Deborah J Sharp, Peter Whincup, Stuart Logan, Derek Cook, Robert Moore, Salman Rawaf, J McEewen, Robert West, John S Yudkin, Aileen Clarke, Nick Finer, Paola Domizio, Clare Bambra, Anna Jones, Gene Feder, Alex Scott-Samuel, Louise Irvine, Ajay Sharma, Mike Fitchett, Kambiz Boomla, Jonathan Folb, Ashish Paul, David McCoy, Ray Tallis, Jilla Burgess-Allen, Mark Edwards, Jonathon Tomlinson, Deborah Colvin, Jonathan Gore, Kirsten Brown, Sarah Mitchel, Alice Lau, Mel Sayer, Leon Clark, Ruth Silverman, Saul Marmot, Daniel Rainbow, Lucy Carter, Nick Mann, Richard Fielding, Jane Logan, Louise Tebboth, Natasha Arnold, Kate Stobbart, Kate Cabot, Sarah Finer, Martin Edwards, David Davies, Helen Buttivant, Sebastian Kraemer, Jo Newell, Alun Griffiths, Richard Fitzgerald, Robert Macgibbon, Alan Lee, A F Macklon, Esther Hobson, David Jenner, Bobbie Jacobson, Alison Timmis, Asad Salim, John Evans-Jones, Woody Caan, Ninaad Awsare, Neil Pride, Ruth Suckling, Catherine Bratty, Brian Rossiter, David Hawkins, Jonny Currie, Corinne Camilleri-Ferrante, Jonathan Fluxman, Osman Bhatti, James Anson, Robert Etherington, David Lawrence, Henry Fell, Edward Clarke, Julian Ormerod, Oliver Ormerod, Maggie Ireland, John A T Duncan, Rajiv Chandy, Jennifer Mindell, Paul Mullen, Phillip Bennett-Richards, Julie Hirst, E Murphy, P Martin, Simon Lowes, Peter Fleming, Richard Grunewald, Joanne Reeve, Martin Schweiger, Jonathan Coates, George Farrelly, M A Chamberlain, Geoffrey Lewis, Jane Young, Brian Scott, John Gibbs, Aileen Landers, Pete Deveson, Grant Ingrams, Martha Leigh, Jeff Gawler, Amy Ford, Jonathan Nixon, Margaret McCartney, David Bareford, Surinder Singh, Kate Lockwood, Michael Cripwell, Peter Ehrhardt, David Bell, Pam Wortley, Laurie Tomlinson, Julie Hotchkiss, Steven Ford, Gill Turner, Gerard Reissman, David Lewis, Chris Johnstone, Mike Tomson, Payam Torabi, David Bell, D Tomson, Alex Tulloch, Sally Johnston, Jane Dickinson, Elisabeth McElderry, Wendy Ross, Kim Holt, Mary Logan, Hilary Klonin, David Jenner, Jude Danby, V Goodger, John Puntis, Harriet Dickson, Derek A Gould, Anna Livingstone, Dianne Lefevre, Bryony Kendall, G Singh, Peter Hall, Jonathan Darling, Adrian N Hamlyn, Anita Patel, Jonathan Erskine, Brian Fisher, Richard Hughes, Clare Highton, Helen Venning, Ron Singer, Steve Brearey, Jim Sikorski, David Paintin, John Feehally, Wendy Savage, Kathy McAdam Freud, Victoria J Holt, Alison Gill, Tony Waterston, Richard de Souza, Nicholas Hopkinson, Mike Beadsworth, Andrea Franks, Helen Daley, Paul Cullinan, Adriana Basarab, Jonathan Folb, Hugh Gurling, Pam Zinkin, Simon Kirwin, Ernst Buhrs, Raymond Brown, Andrew West, Gary Marlowe, Griffith Fellows, John Main, Jackie Applebee, M Koperski, Phil Jones, Alison Macfarlane, Naomi Beer, Rebecca Mason, Robert West, Maggie Eisner, Alison Smailes, Philip Timms, David Knight, Coral Jones, Barbara Wesby, Laura Lyttelton, Richard Morrison, David Bossano, Jonathan Walker, Gerry Davies, Peter Godfrey, Ingrid Wolfe, Emmanuel Nsutebu, Nicola Stevenson, Sheila Cheeroth, Jo Miller, Guy Johnson, R Noor, Alyson Hall, David Bostock, Benedict Michael, John Sharvill, Jamie Macpherson, David Lewis, Richard Ma, John Middleton, Anne Jeffreys, Jim Cole, John P Boswell, Bob Bury, Sally Mitchison, Ann-Louise Kinmonth, Gail Young, Iain Maclennan, Pat Munday
No abstract text is available yet for this article.
March 20, 2013: BMJ: British Medical Journal
#26
REVIEW
Angela Applebee
Multiple sclerosis (MS) and migraine headache coexist in many young female patients. Whether this is coincidental or causally linked remains unclear. The presenting symptoms and signs of MS relapse and migraine aura can be similar and should be differentiated by careful history and examination to ensure proper diagnosis and treatment. White matter lesions on magnetic resonance imaging have specific patterns for each entity and also need to be interpreted carefully. Although a clear link has not been established between migraine and MS, numerous studies have been reported assessing risks, prevalence, and causation...
October 2012: Headache
#27
JOURNAL ARTICLE
Richard D Byrne, Christopher Applebee, Dominic L Poccia, Banafshé Larijani
The nuclear envelope (NE) breaks down and reforms during each mitotic cycle. A similar process happens to the sperm NE following fertilisation. The formation of the NE in both these circumstances involves endoplasmic reticulum membranes enveloping the chromatin, but PLCγ-dependent membrane fusion events are also essential. Here we demonstrate the activation of PLCγ by a Src family kinase (SFK1) during NE assembly. We show by time-resolved FRET for the first time the direct in vivo interaction and temporal regulation of PLCγ and SFK1 in sea urchins...
2012: PloS One
#28
REVIEW
Hillel Panitch, Angela Applebee
INTRODUCTION: Walking impairment is a clinical hallmark of multiple sclerosis (MS), a chronic neurologic disease characterized by axonal demyelination and dysfunction that results in progressive disability. Until recently, there were no therapies that specifically targeted the axonal dysfunction associated with walking impairment in MS. AREAS COVERED: The purpose of this review is to discuss the unmet need for the treatment of walking impairment in MS patients and to evaluate how a new class of pharmacologic therapies, neurofunctional modifiers, potentially addresses this unmet need...
July 2011: Expert Opinion on Pharmacotherapy
#29
JOURNAL ARTICLE
M Kenyon Applebee, Andrew R Joyce, Tom M Conrad, Donald W Pettigrew, Bernhard Ø Palsson
Herein we measure the effect of four adaptive non-synonymous mutations to the glycerol kinase (glpK) gene on catalytic function and regulation, to identify changes that correlate to increased fitness in glycerol media. The mutations significantly reduce affinity for the allosteric inhibitor fructose-1,6-bisphosphate (FBP) and formation of the tetramer, which are structurally related, in a manner that correlates inversely with imparted fitness during growth on glycerol, which strongly suggests that these enzymatic parameters drive growth improvement...
July 1, 2011: Journal of Biological Chemistry
#30
JOURNAL ARTICLE
Mario A Monteiro, Stacey Britton, Lisa A Applebee, Shahida Baqar
Helicobacter pylori infection in humans is responsible for the onset of severe gastric disorders and a vaccine would be an improvement over current antibiotic-based treatments. Lipopolysaccharide (LPS; O-chain PS→core→lipid A) is a main H. pylori cell wall component, whose O-chain PS exhibits molecular mimicry and therefore any LPS-based vaccine cannot contain O-chain epitopes. Here, the conjugation of de-lipidated H. pylori O:2 LPS to BSA and its immunogenicity in mice is described. IgG antibodies were observed to recognize the LPSs of representative H...
April 12, 2011: Vaccine
#31
JOURNAL ARTICLE
Thomas A Masters, Véronique Calleja, Daven A Armoogum, Richard J Marsh, Christopher J Applebee, Michel Laguerre, Angus J Bain, Banafshé Larijani
3-Phosphoinositide-dependent kinase 1 (PDK1) plays a central role in regulating the activity of protein kinases that are essential for signaling; however, how PDK1 itself is regulated is largely unknown. We found that homodimerization of PDK1 is a spatially and temporally regulated mechanism for controlling PDK1 activity. We used Förster resonance energy transfer monitored by fluorescence lifetime imaging microscopy to observe PDK1 homodimerization in live cells. A pleckstrin homology (PH) domain-dependent, basal dimeric association of PDK1 was increased upon cell stimulation with growth factors; this association was prevented by a phosphatidylinositol 3-kinase inhibitor and by a mutation in, or a complete deletion of, the PH domain of PDK1...
2010: Science Signaling
#32
JOURNAL ARTICLE
David R Tribble, Shahida Baqar, Daniel A Scott, Michael L Oplinger, Fernando Trespalacios, David Rollins, Richard I Walker, John D Clements, Steven Walz, Paul Gibbs, Edward F Burg, Anthony P Moran, Lisa Applebee, A Louis Bourgeois
A human Campylobacter jejuni infection model provided controlled exposure to assess vaccine efficacy and investigate protective immunity for this important diarrheal pathogen. A well-characterized outbreak strain, C. jejuni 81-176, was investigated using a volunteer experimental infection model to evaluate the dose range and duration of protection. Healthy Campylobacter-seronegative adults received C. jejuni strain 81-176 via oral inoculation of 10(5), 10(7), or 10(9) CFU (5 adults/dose), which was followed by clinical and immunological monitoring...
April 2010: Infection and Immunity
#33
JOURNAL ARTICLE
Garrick A Applebee, Hrayr P Attarian, Carlos H Schenck
No abstract text is available yet for this article.
October 15, 2009: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
#34
JOURNAL ARTICLE
Tom M Conrad, Andrew R Joyce, M Kenyon Applebee, Christian L Barrett, Bin Xie, Yuan Gao, Bernhard Ø Palsson
BACKGROUND: Short-term laboratory evolution of bacteria followed by genomic sequencing provides insight into the mechanism of adaptive evolution, such as the number of mutations needed for adaptation, genotype-phenotype relationships, and the reproducibility of adaptive outcomes. RESULTS: In the present study, we describe the genome sequencing of 11 endpoints of Escherichia coli that underwent 60-day laboratory adaptive evolution under growth rate selection pressure in lactate minimal media...
2009: Genome Biology
#35
JOURNAL ARTICLE
Kevin W Nemelka, Ammon W Brown, Shannon M Wallace, Erika Jones, Ludmila V Asher, Dawn Pattarini, Lisa Applebee, Theron C Gilliland, Patricia Guerry, Shahida Baqar
Campylobacter jejuni is 1 of the most common enteric bacterial pathogens worldwide. The mechanisms of pathogenesis remain obscure, in part because of limitations of small animal models. Young ferrets develop diarrhea when fed C. jejuni, but their pathology and the immune response after infection have not been examined in detail. In the present study, we examined the pathogenesis of C. jejuni CG8421 and associated immune responses in ferrets. After oral infection with C. jejuni CG8421, 86.7% of the animals developed diarrhea and inflammatory responses that were similar to those seen in human infection...
August 2009: Comparative Medicine
#36
JOURNAL ARTICLE
Angela Applebee, Hillel Panitch
Multiple sclerosis (MS) affects young adults during the most productive years of their lives, and until recently many neurologists were limited to treating symptoms and attacks without any ability to alter the disease course. The 1990s ushered in an era of possibility with the approval of three interferon-beta (IFNbeta) therapies for the treatment of MS. Though the mechanism of action of these agents is not completely understood, it is clear they reduce magnetic resonance imaging (MRI) activity as well as improve clinical outcomes...
2009: Biologics: Targets & Therapy
#37
JOURNAL ARTICLE
Mario A Monteiro, Shahida Baqar, Eric R Hall, Yu-Han Chen, Chad K Porter, David E Bentzel, Lisa Applebee, Patricia Guerry
The capsule polysaccharide (CPS) of Campylobacter jejuni is one of the few identified virulence determinants of this important human pathogen. Since CPS conjugate vaccines have been so effective against other mucosal pathogens, we evaluated this approach using CPSs from two strains of C. jejuni, 81-176 (HS23 and HS36 serotype complex) and CG8486 (HS4 serotype complex). The CPSs of 81-176 and CG8486 were independently linked to the carrier protein CRM(197) by reductive amination between an aldehyde(s), strategically created at the nonreducing end of each CPS, and accessible amines of CRM(197)...
March 2009: Infection and Immunity
#38
JOURNAL ARTICLE
Garrick A Applebee, Peter M Bingham, Hrayr P Attarian
No abstract text is available yet for this article.
June 2009: Clinical Pediatrics
#39
JOURNAL ARTICLE
Garrick A Applebee, Ann P Guillot, Catherine C Schuman, Sarah Teddy, Hrayr P Attarian
Sleep disorders have been shown to be more prevalent in adults and children with chronic kidney disease (CKD) and on dialysis. To date, the prevalence and impact of restless legs syndrome (RLS) in various stages of CKD has not been evaluated. The object of this study was to determine the prevalence of RLS in children with CKD in different stages, and to evaluate its impact on sleep and daytime functioning. We conducted a clinic-based or telephone survey of 26 patients in varying stages of CKD to assess for RLS, sleep schedule, and daytime sleepiness...
March 2009: Pediatric Nephrology
#40
JOURNAL ARTICLE
Kristie M Sullivan, Michael A Erickson, Chad B Sandusky, Neal D Barnard
Heterocyclic amines (HCAs), compounds formed when meat is cooked at high temperatures particularly through pan frying, grilling, or barbequing, pose a potential carcinogenic risk to the public. It is unclear whether there is any level at which consumption of HCAs can be considered safe. Efforts to measure these compounds mainly include cooking studies under laboratory conditions and some measurement of home-cooked foods, but analysis of commercially cooked foods has been minimal. Attempts to estimate exposure of the public to these compounds must take into consideration dining outside the home, which could result in significant exposure for some individuals...
2008: Nutrition and Cancer
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