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https://www.readbyqxmd.com/read/27922256/statins-in-critical-care-to-give-or-not-to-give
#1
Amr S Omar, Samy Hanoura, Haifa M Aljanubi, Ahmed Mahfouz
Owing to statin's immune modulatory, anti-inflammatory, antioxidant, antithrombotic and endothelial function actions, they are widely used in the critical care settings in diverse disease scenarios. We aim to explore the evidence to globalize the utilization of statins in the intensive care practice for different indications. We carried out a search of the PubMed, Cochrane and EMBASE databases up to January 2016. We included review articles, meta-analyses, and original trials on the effects of statin therapy in the intensive care unit (ICU) combining the following MESH terms: 'satins', 'intensive care, 'cardiac surgery', 'sepsis', 'acute respiratory distress syndrome' 'pneumonia', subarachnoid hemorrhage', traumatic brain injury and 'critical illness'...
December 6, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27922255/risk-factors-for-nocturnal-hypoxemia-in-severe-osa-patients
#2
Eric Deflandre, Damien Kempeneers, Stephanie Degey, Robert Poirrier, Pascal Legros, Jean F Brichant, Jean Joris
BACKGROUND: Severe obstructive sleep apnea (sOSA) and oxygen desaturations are both risk factors for postoperative complications. In some but not all patients, sOSA is associated with frequent oxygen desaturation episodes during sleep. The aim of this retrospective study was to identify the risk factors for exhibiting oxygen desaturation in patients with sOSA. METHODS: Records of 786 patients, mainly obese (Body Mass Index [mean + SD] = 30.2 + 6.0 kg/m2), were analyzed...
December 6, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27922203/vulnerability-to-alcohol-related-problems-a-policy-brief-with-implications-for-the-regulation-of-alcohol-marketing
#3
Thomas F Babor, Katherine Robaina, Jonathan K Noel, E Bruce Ritson
BACKGROUND AND AIMS: The concern that alcohol advertising can have detrimental effects on vulnerable viewers has prompted the development of codes of responsible advertising practices. This paper evaluates critically the concept of vulnerability as it applies to (1) susceptibility to alcohol-related harm and (2) susceptibility to the effects of marketing, and describes its implications for the regulation of alcohol marketing. METHOD: We describe the findings of key published studies, review papers and expert reports to determine whether these two types of vulnerability apply to population groups defined by (1) age and developmental history; (2) personality characteristics; (3) family history of alcoholism; (4) female sex and pregnancy risk; and (5) history of alcohol dependence and recovery status...
December 6, 2016: Addiction
https://www.readbyqxmd.com/read/27922201/high-performance-air-stable-field-effect-transistors-based-on-heteroatom-substituted-naphthalenediimide-benzothiadiazole-copolymers-exhibiting-ultrahigh-electron-mobility-up-to-8-5-cm-v-1-s-1
#4
Zhiyuan Zhao, Zhihong Yin, Huajie Chen, Liping Zheng, Chunguang Zhu, Long Zhang, Songting Tan, Hanlin Wang, Yunlong Guo, Qingxin Tang, Yunqi Liu
Rational heteroatom engineering is applied to develop high-performance electron-transporting naphthalenediimide copolymers. Top-gate field-effect transistors fabricated from selenophene-containing polymers achieve an ultrahigh electron mobility of 8.5 cm(2) V(-1) s(-1) and excellent air-stability. The results demonstrate that the incorporation of selenophene heterocycles into the polymers can improve film-forming ability, intermoleclar interaction, and carrier transport significantly.
December 6, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27922190/clc-3-promotes-osteogenic-differentiation-in-mc3t3-e1-cell-after-dynamic-compression
#5
Dawei Wang, Hao Wang, Feng Gao, Kun Wang, Fusheng Dong
ClC-3 chloride channel has been proved to have a relationship with the expression of osteogenic markers during osteogenesis, persistent static compression can upregulate the expression of ClC-3 and regulate osteodifferentiation in osteoblasts. However, there was no study about the relationship between the expression of ClC-3 and osteodifferentiation after dynamic compression. In this study, we applied dynamic compression on MC3T3-E1 cells to detect the expression of ClC-3, runt-related transcription factor 2 (Runx2), bone morphogenic protein-2 (BMP-2), osteopontin (OPN), nuclear-associated antigen Ki67 (Ki67) and proliferating cell nuclear antigen (PCNA) in biopress system, then we investigated the expression of these genes after dynamic compression with Chlorotoxin (specific ClC-3 chloride channel inhibitor) added...
December 6, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27922184/europium-iii-and-uranium-vi-complexation-by-natural-organic-matter-nom-effect-of-source
#6
Ralf Kautenburger, Jonas M Sander, Christina Hein
For the safe long-term storage of high level radioactive waste (HLW), detailed information about geo-chemical behavior of radioactive and toxic metal ions under environmental conditions is important. Natural organic matter (NOM) can play a crucial role in the immobilization or mobilization of these metal ions due to its complexation and colloid formation tendency. In this study, the complexation of europium (as chemical homologue of trivalent actinides like americium) and uranium (as main component of HLW) by ten humic acids (HA) from different sources and Suwannee NOM river extract has been analyzed...
December 6, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27922180/going-domestic-importing-the-study-abroad-experience-the-development-of-a-multicultural-new-york-city-study-away-program
#7
Susan Hayes Lane, Carolyn Huffman, Dana E Brackney, Alyssa Cuddy
PROBLEM: Significant off-campus domestic study away experiences have been shown to be a transformative active learning environment for students and achieve similar learning outcomes as study abroad programs. METHODS: This manuscript describes the conception, development, and pedagogical approach of a faculty-led domestic study away experience in New York City for pre-licensure and post-licensure nursing students as an active learning strategy for developing cultural competence...
December 6, 2016: Nursing Forum
https://www.readbyqxmd.com/read/27922179/a-carbon-dioxide-stripping-model-for-mammalian-cell-culture-in-manufacturing-scale-bioreactors
#8
Zizhuo Xing, Amanda M Lewis, Michael C Borys, Zheng Jian Li
Control of carbon dioxide within the optimum range is important in mammalian bioprocesses at the manufacturing scale in order to ensure robust cell growth, high protein yields, and consistent quality attributes. The majority of bioprocess development work is done in laboratory bioreactors, in which carbon dioxide levels are more easily controlled. Some challenges in carbon dioxide control can present themselves when cell culture processes are scaled up, because carbon dioxide accumulation is a common feature due to longer gas-residence time of mammalian cell culture in large scale bioreactors...
December 6, 2016: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/27922124/convex-analysis-of-mixtures-for-separating-non-negative-well-grounded-sources
#9
Yitan Zhu, Niya Wang, David J Miller, Yue Wang
Blind Source Separation (BSS) is a powerful tool for analyzing composite data patterns in many areas, such as computational biology. We introduce a novel BSS method, Convex Analysis of Mixtures (CAM), for separating non-negative well-grounded sources, which learns the mixing matrix by identifying the lateral edges of the convex data scatter plot. We propose and prove a sufficient and necessary condition for identifying the mixing matrix through edge detection in the noise-free case, which enables CAM to identify the mixing matrix not only in the exact-determined and over-determined scenarios, but also in the under-determined scenario...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27922095/co-expression-network-analyses-identify-functional-modules-associated-with-development-and-stress-response-in-gossypium-arboreum
#10
Qi You, Liwei Zhang, Xin Yi, Kang Zhang, Dongxia Yao, Xueyan Zhang, Qianhua Wang, Xinhua Zhao, Yi Ling, Wenying Xu, Fuguang Li, Zhen Su
Cotton is an economically important crop, essential for the agriculture and textile industries. Through integrating transcriptomic data, we discovered that multi-dimensional co-expression network analysis was powerful for predicting cotton gene functions and functional modules. Here, the recently available transcriptomic data on Gossypium arboreum, including data on multiple growth stages of tissues and stress treatment samples were applied to construct a co-expression network exploring multi-dimensional expression (development and stress) through multi-layered approaches...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27922011/detecting-stoichiometry-of-macromolecular-complexes-in-live-cells-using-fret
#11
Manu Ben-Johny, Daniel N Yue, David T Yue
The stoichiometry of macromolecular interactions is fundamental to cellular signalling yet challenging to detect from living cells. Fluorescence resonance energy transfer (FRET) is a powerful phenomenon for characterizing close-range interactions whereby a donor fluorophore transfers energy to a closely juxtaposed acceptor. Recognizing that FRET measured from the acceptor's perspective reports a related but distinct quantity versus the donor, we utilize the ratiometric comparison of the two to obtain the stoichiometry of a complex...
December 6, 2016: Nature Communications
https://www.readbyqxmd.com/read/27921999/lift-calculations-based-on-accepted-wake-models-for-animal-flight-are-inconsistent-and-sensitive-to-vortex-dynamics
#12
Eric Gutierrez, Daniel B Quinn, Diana D Chin, David Lentink
There are three common methods for calculating the lift generated by a flying animal based on the measured airflow in the wake. However, these methods might not be accurate according to computational and robot-based studies of flapping wings. Here we test this hypothesis for the first time for a slowly flying Pacific parrotlet in still air using stereo particle image velocimetry recorded at 1000 Hz. The bird was trained to fly between two perches through a laser sheet wearing laser safety goggles. We found that the wingtip vortices generated during mid-downstroke advected down and broke up quickly, contradicting the frozen turbulence hypothesis typically assumed in animal flight experiments...
December 6, 2016: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/27921634/smoking-cessation-in-smoke-free-prisons-a-grounded-theory-study
#13
Ashleigh Djachenko, Winsome St John, Creina Mitchell
Purpose Prisoners are vulnerable to tobacco addiction and have a smoking prevalence significantly higher than that of the general community. The context of this study was the implementation of a "smoke-free prisons" policy, which imposed forced smoking cessation onto the Queensland, Australian prison population. The study asked the question: "What are the psychosocial processes in which male prisoners engage during smoking cessation in a smoke-free environment?" Design/methodology/approach Qualitative interviews were conducted with 15 prisoners in South-east Queensland smoke-free correctional centres...
December 19, 2016: International Journal of Prisoner Health
https://www.readbyqxmd.com/read/27921519/different-responses-of-drosophila-subobscura-isofemale-lines-to-extremely-low-frequency-magnetic-field-50%C3%A2-hz-0-5%C3%A2-mt-fitness-components-and-locomotor-activity
#14
Danica Zmejkoski, Branka Petković, Sofija Pavković-Lučić, Zlatko Prolić, Marko Anđelković, Tatjana Savić
PURPOSE: Extremely low frequency (ELF) magnetic fields as essential ecological factor may induce specific responses in genetically different lines. The subject of this study was to investigate the impact of ELF magnetic field on fitness components and locomotor activity of five Drosophila subobscura isofemale (IF) lines. MATERIALS AND METHODS: Each D. subobscura IF line, arbitrarily named: B16/1, B24/4, B39/1, B57/2 and B69/5, was maintained in five full-sib inbreeding generations...
December 6, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27921518/increased-radio-toxicity-in-two-cancerous-cell-lines-irradiated-by-low-and-high-energy-photons-in-the-presence-of-thio-glucose-bound-gold-nanoparticles
#15
Shokouhozaman Soleymanifard, Atefeh Rostami, Seyed Amir Aledavood, Maryam Moghadam Matin, Ameneh Sazgarnia
PURPOSE: Gold nanoparticles modified by thio-glucose have been believed to increase the toxicity of radiotherapy in human malignant cells. We report the effect of thio-glucose-bound gold nanoparticles (Glu-G nanoparticles), 16 nm in size, on two human lung (QU-DB) and breast (MCF7) cancer cell lines combined with kilo and megavoltage X-rays. MATERIALS AND METHODS: The shape and surface characteristics, the size distribution and light absorption spectrum of the prepared nanoparticles were measured by transmission electron microscopy, dynamic light scattering, and Ultraviolet-Visible spectrophotometry, respectively...
December 6, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27921462/surgical-management-of-primary-parapharyngeal-space-tumors-a-10-year-review
#16
Xiaoling Shi, Lei Tao, Xiaoming Li, Haitao Wu, Weiting Huang, Xiaoling Chen, Cai Li, Yan Shen, Qi Chen, Di Tang, Chunsheng Wei, Dehui Wang, Liang Zhou
CONCLUSIONS: Most neoplasms of the parapharyngeal space are benign. The transcervical surgical approach is the preferred procedure in most cases. Intra-operative endoscopic exploration offers a new surgical management technique to reduce operative complications and post-operative recurrence rates. OBJECTIVES: To present the authors' experience in the treatment of primary parapharyngeal space tumors with emphasis on surgical approaches and employment of endoscopy to detect residual tumors through conventional approaches...
December 6, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27921458/metabolic-profile-of-human-coelomic-fluid
#17
C Virgiliou, L Valianou, M Witting, F Moritz, C Fotakis, P Zoumpoulakis, A C Chatziioannou, L Lazaros, G Makrydimas, K Chatzimeletiou, N Raikos, G A Theodoridis
AIM: Till now there is very limited knowledge on the molecular content of coelomic fluid and cells. This study presents the first attempt to elucidate the metabolic profile of such samples. METHODOLOGY: Samples were collected via coelocentesis from 41 women during the first trimester of gestation. Metabolic content was assessed using four different analytical platforms. For targeted analysis a hydrophilic interaction chromatography ultra high performance LC-MS/MS method was applied...
January 2017: Bioanalysis
https://www.readbyqxmd.com/read/27921455/lipoprotein-profiling-methodology-based-on-determination-of-apolipoprotein-concentration
#18
Hiroaki Takeda, Yoshihiro Izumi, Atsumi Tomita, Tomonari Koike, Masashi Shiomi, Eiichiro Fukusaki, Fumio Matsuda, Takeshi Bamba
AIM: Abnormal lipid metabolism results in the alteration of lipid compositions in lipoproteins; therefore an accurate and quantitative analytical approach is required for the detailed structural characterization of lipoproteins. However, the specific lipid composition of each lipoprotein particle is poorly understood. MATERIALS & METHODS: Lipid composition of very-low-density lipoprotein and low-density lipoprotein particles derived from myocardial infarction-prone rabbits was determined by normalization of lipidomics data using apoB-100 levels...
January 2017: Bioanalysis
https://www.readbyqxmd.com/read/27921444/estimating-cancer-induction-risk-from-abdominopelvic-scanning-with-6-and-16-slice-computed-tomography
#19
Parinaz Mehnati, Ayoub Amirnia, Nasrollah Jabbari
PURPOSE: The biological effects of ionizing radiation (BEIRVII) report estimates that the risk of getting cancer from radiation is increased by about a third from current regulation risk levels. The propose of this study was to estimate cancer induction risk from abdominopelvic computed tomography (CT) scanning of adult patients using 6- and 16-slice CT scanners. MATERIALS AND METHODS: A cross-sectional study on 200 patients with abdominopelvic CT scan in 6- and 16-slice scanners was conducted...
December 6, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27921382/core-shell-silk-hydrogels-with-spatially-tuned-conformations-as-drug-delivery-system
#20
Le-Ping Yan, Joaquim M Oliveira, Ana L Oliveira, Rui L Reis
Hydrogels of spatially controlled physicochemical properties are appealing platforms for tissue engineering and drug delivery. In this study, core-shell silk fibroin (SF) hydrogels of spatially controlled conformation were developed. The core-shell structure in the hydrogels was formed by means of soaking the preformed (enzymatically crosslinked) random coil SF hydrogels in methanol. When increasing the methanol treatment time from 1 to 10 min, the thickness of the shell layer can be tuned from about 200 to about 850 μm as measured in wet status...
December 5, 2016: Journal of Tissue Engineering and Regenerative Medicine
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