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Virág Bogdándi, Tomoaki Ida, Thomas R Sutton, Christopher Bianco, Tamás Ditrói, Grielof Koster, Hillary A Henthorn, Magda Minnion, John P Toscano, Albert van der Vliet, Michael D Pluth, Martin Feelisch, Jon M Fukuto, Takaaki Akaike, Péter Nagy
BACKGROUND AND PURPOSE: Posttranslational modifications of cysteine (Cys) residues represent a major aspect of redox biology, and their reliable detection is key in providing mechanistic insights. The metastable character of these modifications and cell lysis-induced artifactual oxidation render current state-of-the-art protocols to rely on alkylation-based stabilization of labile Cys derivatives before cell/tissue rupture. An untested assumption in these procedures is that for all Cys derivatives alkylation rates are faster than their dynamic interchange...
June 17, 2018: British Journal of Pharmacology
Claire M B Holloway, Li Jiang, Marlo Whitehead, Jennifer M Racz, Patti A Groome
PURPOSE: Mortality reduction attributable to organized breast screening is modest. Screening may be less effective at detecting more aggressive cancers at an earlier stage. This study was conducted to determine the relative efficacy of screening mammography to detect cancers at an earlier stage by molecular phenotype. METHODS: We identified 2882 women with primary invasive breast cancer diagnosed between January 1, 2008 and December 31, 2012 and who had a mammogram through the Ontario Breast Screening Program in the 28 months before diagnosis...
June 16, 2018: Journal of Cancer Research and Clinical Oncology
Urska Nabergoj Makovec, Mitja Kos, Nina Pisk
Background In December 2014 Slovene Chamber of Pharmacies defined procedures for Medicines Use Review (MUR) in Slovenia, together with an educational program and certification to ensure pharmacists' competency to perform MUR. The first 15 pharmacists were certified in June 2015 and implemented the service in their practices. Objective This study aimed to understand the implementation of MUR from the perspectives of the first community pharmacists providing the service in practice. Methods A focus group with first MUR providers took place in February 2016, 6 months after the first pharmacists were certified to provide MUR service...
June 16, 2018: International Journal of Clinical Pharmacy
Radhika Patnam, Autumn Edenfield, Steven Swift
INTRODUCTION AND HYPOTHESIS: The purpose of this study is to reanalyze data from the original 2005 Pelvic Organ Support Study (POSST) data set to define normal values for apical Pelvic Organ Prolapse Quantification (POP-Q) points C and D and total vaginal length (TVL) in an asymptomatic population of women. METHODS: In this retrospective observational data-set review, patient were >18 years presenting for annual gynecologic exams to six centers in the United States...
June 16, 2018: International Urogynecology Journal
Claudia R Kowalik, Mariëlle M E Lakeman, Alyde T de Kraker, Jan Paul W R Roovers
INTRODUCTION AND HYPOTHESIS: Vaginal mesh surgery is subject of debate due to the impact of mesh-related complications on patient's lives. Not all of these complications are symptomatic. Restoration of the anatomy and improvement of pelvic floor function as a result may counter the experienced discomfort related to adverse events. We hypothesized that health-related quality of life (HR-QoL) is comparable in women after vaginal mesh surgery regardless of the presence or absence of a mesh-specific complication...
June 16, 2018: International Urogynecology Journal
S M Esteves, S F P Almeida, S Gonçalves, F Rimet, A Bouchez, E Figueira
Organic contaminants, and herbicides in particular, represent a risk for aquatic ecosystems. The primary target of herbicides are producers, the base of food webs, but frequently they end up far from the application point affecting non-target species. Its presence can work as sub-lethal stimulus, which sort the genetic and phenotypic differences within a species. Intraspecific variation allows adaptation to changes in the environment but also to new niches due to variations in species' sensitivity and biochemical response to a certain chemical...
June 16, 2018: Ecotoxicology
Andrea Pio-Abreu, Luciano F Drager
PURPOSE OF REVIEW: Resistant hypertension (RH) is a growing clinical condition worldwide associated with target-organ damage and poor prognosis compared to non-resistant counterparts. The purpose of this review is to perform a critical evaluation of preferable drug choices for managing RH highlighting the evidence that significant proportion of patients remained uncontrolled despite using four anti-hypertensive drugs. RECENT FINDINGS: Until recently, the fourth drug therapy was main derived from personal opinion or small interventional studies...
June 16, 2018: Current Hypertension Reports
Emese Hadnagy, Andrew Mai, Benjamin Smolinski, Washington Braida, Agamemnon Koutsospyros
The manufacturing of insensitive munition 2,4-dinitroanisole (DNAN) generates waste streams that require treatment. DNAN has been treated previously with zero-valent iron (ZVI) and Fe-based bimetals. Use of Mg-based bimetals offers certain advantages including potential higher reactivity and relative insensitivity to pH conditions. This work reports preliminary findings of DNAN degradation by three Mg-based bimetals: Mg/Cu, Mg/Ni, and Mg/Zn. Treatment of DNAN by all three bimetals is highly effective in aqueous solutions (> 89% removal) and wastewater (> 91% removal) in comparison with treatment solely with zero-valent magnesium (ZVMg; 35% removal)...
June 16, 2018: Environmental Science and Pollution Research International
Erica Szkody, Mary Moussa Rogers, Cliff McKinney
PURPOSE: Parent-child relationship quality is an important factor when examining adolescent's risk for problem behaviors. For this reason, many researchers have explored the impacts of parent-child relationship quality on adolescent and child behavior, yet the parent-child relationship has lasting consequences into adulthood. METHODS: The current study examined the mediating role of risky sexual behavior (as measured by the Youth Risk Behavior Survey) on the relationship between parent-child relationship quality (as measured by the Parental Environment Questionnaire) and quality of life (as measured by the World Health Organizations Quality of Life Questionnaire) beyond adolescence, during emerging adulthood...
June 16, 2018: Quality of Life Research
Olga E Redina, Arcady L Markel
PURPOSE OF REVIEW: Acute psychoemotional stress is one of the causes of a sharp increase in blood pressure. However, the question if the stress may promote the hypertensive disease development is still open. This review aims, firstly, to show that the genetically determined enhanced responsiveness to stress is linked to sustained hypertension development and, secondly, to characterize the main physiological mechanisms and genetic factors implicated in the pathogenesis of stress-sensitive hypertension...
June 16, 2018: Current Hypertension Reports
Jérémy Decroix, Solène Kalénine
Several models of action recognition acknowledge the involvement of distinct grip and goal representations in the processing of others' actions. Yet, their functional role and temporal organization are still debated. The present priming study aimed at evaluating the relative timing of grip and goal activation during the processing of photographs of object-directed actions. Action could be correct or incorrect owing to grip and/or goal violations. Twenty-eight (Experiment 1) and 25 (Experiment 2) healthy adults judged the correctness of target actions according to object typical use...
June 16, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
K Keely Boyle, Sridhar Rachala, Scott R Nodzo
PURPOSE OF REVIEW: The associated patient morbidity and resource-intensive nature of managing surgical site infections (SSI) has focused attention toward not only improving treatment protocols but also enhancing preventative measures. The purpose of this review was to summarize the relevant updated CDC guidelines for the prevention of SSI that were released in 2017. The CDC recommends the integration of the guidelines for improvement in quality metrics, reportable outcomes, and patient safety...
June 16, 2018: Current Reviews in Musculoskeletal Medicine
Milad Mirzaei Aminiyan, Jacqueline Aitkenhead-Peterson, Farzad Mirzaei Aminiyan
The main purpose of this study was to evaluate the water quality of the Karoon river, which is a main river in Iran country. For this purpose, hydrochemical analyses of a database that maintained by the Water Resources Authority of Khuzestan Province, Iran's Ministry of Energy, were carried out. These data were compared with the maximum permissible limit values recommended by World Health Organization and Food and Agriculture Organization water standards for drinking and agricultural purposes, respectively...
June 16, 2018: Environmental Geochemistry and Health
Audrey Hammack, Rashed T Rihani, Bryan J Black, Joseph J Pancrazio, Bruce E Gnade
Substrate-integrated microelectrode arrays (MEAs) are non-invasive platforms for recording supra-threshold signals, i.e. action potentials or spikes, from a variety of cultured electrically active cells, and are useful for pharmacological and toxicological studies. However, the MEA substrate, which is often fabricated using semiconductor processing technology, presents some challenges to the user. Specifically, the electrode encapsulation, which may consist of a variety of inorganic and organic materials, requires a specific substrate preparation protocol to optimize cell adhesion to the surface...
June 16, 2018: Biomedical Microdevices
Victor D Plat, Nora van Gaal, James A Covington, Matthew Neal, Tim G J de Meij, Donald L van der Peet, Babs Zonderhuis, Geert Kazemier, Nanne K H de Boer, Freek Daams
BACKGROUND: Esophagectomy or pancreaticoduodenectomy is the standard surgical approach for patients with tumors of the esophagus or pancreatic head. Postoperative mortality is strongly correlated with the occurrence of anastomotic leakage (AL). Delay in diagnosis leads to delay in treatment, which ratifies the need for development of novel and accurate non-invasive diagnostic tests for detection of AL. Urinary volatile organic compounds (VOCs) reflect the metabolic status of an individual, which is associated with a systemic immunological response...
June 15, 2018: Digestive Surgery
Ei Wakamatsu, Hiroki Omori, Shizuka Ohtsuka, Shuhei Ogawa, Jonathan M Green, Ryo Abe
It is thought that CD28 plays a crucial role in the maintenance of regulatory T cell (Treg) pool size through promoting the development and proliferation of these cells. However, recently we found that the dependency on CD28 co-stimulation for their development is different between Treg subsets, thymus-derived Tregs (tTregs, CD28-dependent) and peripherally-derived Tregs (pTregs, CD28-independent), suggesting that CD28 may also have differential influences on the homeostasis of each Treg subset. Here, we demonstrated that both Treg subsets were reduced in secondary lymphoid organs of CD28 deficient mice, and that this reduction was due to impaired proliferation in both Treg subsets by the intrinsic CD28 defect...
June 14, 2018: Molecular Immunology
Josip Barišić, Vlatka Filipović Marijić, Tatjana Mijošek, Rozelindra Čož-Rakovac, Zrinka Dragun, Nesrete Krasnići, Dušica Ivanković, Dáša Kružlicová, Marijana Erk
In the present study novel histopathological approach, using fish intestine as a sensitive bioindicator organ of pollution impact in the freshwater ecosystem, was proposed. Histopathological alterations were compared between native brown trout (Salmo trutta Linnaeus, 1758) from the reference (Krka River spring) and pollution impacted location (influence of technological/municipal wastewaters and agricultural runoff near the Town of Knin) of the karst Krka River in Croatia. In brown trout from both locations, severe parasitic infestation with acanthocephalan species Dentitruncus trutae was found, enabling evaluation of acanthocephalan infestation histopathology, which indicated parasite tissue reaction in a form of inflammatory, necrotic and hyperplastic response that extended throughout lamina epithelialis mucosae, lamina propria, and lamina muscularis mucosae...
June 14, 2018: Science of the Total Environment
Jie Zhang, Jing You, Huizhen Li, W Tyler Mehler, Eddy Y Zeng
Influence of sediment particle size on the desorption, bioavailability, and bioaccumulation potential of cypermethrin was investigated in the present study using two biomimetic techniques (Tenax extraction and solid-phase microextraction (SPME)) and bioaccumulation testing with Lumbriculus variegatus. A field-collected sediment was wet sieved to obtain five particle-size fractions (<20, 20-63, 63-180, 180-500, and >500 μm) and used for cypermethrin spiking. The finest sediment (<20 μm) had the highest rapid desorption fraction (Fr ) and rate (kr ) when compared to coarser sediments...
June 14, 2018: Science of the Total Environment
Teresa Balbi, Michele Montagna, Rita Fabbri, Cristina Carbone, Silvia Franzellitti, Elena Fabbri, Laura Canesi
Diclofenac-DCF, one of the most widely prescribed non-steroidal anti-inflammatory drug, is globally detected in environmental compartments. Due to its occurrence in freshwater and potential impact on aquatic organisms, it has been added to the watch list of chemicals in the EU Water Directive; consequently, research on the impact of DCF in model aquatic organisms has great regulatory implications towards ecosystem health. DCF is also detected in coastal waters at concentrations from ng/L to 1 μg/L, as well as in marine organisms, such as the mussel Mytilus...
June 14, 2018: Science of the Total Environment
Cheng Zhang, Lusheng Zhu, Jun Wang, Jinhua Wang, Zhongkun Du, Bing Li, Tongtong Zhou, Chao Cheng, Zuobin Wang
Potential toxicity to soil organisms by fluoxastrobin, a new strobilurin-type fungicide has drawn increasing attention. Thus, the present study investigated the subchronic toxicity induced by exposure to several concentrations (0, 0.1, 1.0, and 2.5 mg kg-1 ) of fluoxastrobin to earthworms on days 7, 14, 21, and 28. Biochemical indicators (e.g., reactive oxygen species (ROS) content, activities of antioxidase and detoxifying enzymes (superoxide dismutase, catalase, and glutathione S-transferase), lipid peroxidation (malonaldehyde) and degree of DNA damage) were measured...
June 14, 2018: Science of the Total Environment
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