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https://www.readbyqxmd.com/read/28651374/cd70-a-novel-target-of-car-t-cell-therapy-for-gliomas
#1
Linchun Jin, Haitao Ge, Yu Long, Changlin Yang, Yifan Emily Chang, Luyan Mu, Elias J Sayour, Gabriel De Leon, Qiong J Wang, James C Yang, Paul S Kubilis, Hongbo Bao, Songsong Xia, Dunyue Lu, Yingjun Kong, Li Hu, Yujiao Shang, Chencheng Jiang, Jing Nie, Shimin Li, Yunhe Gu, Jiahang Sun, Duane A Mitchell, Zhiguo Lin, Jianping Huang
Background: Cancer immunotherapy represents a promising treatment approach for malignant-gliomas, but is hampered by the limited number of ubiquitously expressed tumor antigens and the profoundly immunosuppressive tumor microenvironment. We identified CD70 as a novel immunosuppressive ligand and glioma target. Methods: Normal tissues derived from 52 different organs, and primary and recurrent low-grade gliomas (LGGs) and glioblastomas (GBMs) were thoroughly evaluated for CD70 gene and protein expression...
June 23, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28651337/preliminary-validation-of-a-method-combining-cultivation-and-cloning-based-approaches-to-monitor-airborne-bacteria
#2
Jenny Schäfer, Sarah Weiß, Udo Jäckel
It is already known that occupational exposure to bioaerosols or organic dust could be harmful for occupants, but mostly the correlation to occurring bacteria is missing. Especially, cultivation of bacteria from bioaerosols is important to get an insight on occurring and possibly infectious bacteria. These measures are highly time consuming and cost intensive. Therefore, to monitor bacterial diversity in bioaerosol samples and to avoid isolation procedures, an approach was applied using a combination of cultivation and cloning-based approach...
June 23, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28651321/methane-production-and-characteristics-of-the-microbial-community-in-a-two-stage-fixed-bed-anaerobic-reactor-using-molasses
#3
Xingyao Meng, Xufeng Yuan, Jiwei Ren, Xiaofen Wang, Wanbin Zhu, Zongjun Cui
Molasses is a typical feedstock for fermentation, but the effluent is hard to treat. In this study, molasses containing a high concentration of organic matter was treated by a two-stage Fix-bed reactor system with an increased organic loading rate (OLR). The results indicated at high molasses loading rate, the two-stage system was more efficient (i.e. organic matter removal, the COD of effluent and biogas production) than the single-stage system. The relative abundance of Anaerolineaceae and W5_norank was higher in the first stage (R1), where these organisms digest carbohydrates, while the second stage (R2) had higher relative abundance of Synergistaceae and SB-1_norank, which digest VFAs and decomposition-resistant compounds to produce compounds used by hydrogen methanogens...
May 31, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28651318/fate-of-polycyclic-aromatic-hydrocarbons-from-the-north-pacific-to-the-arctic-field-measurements-and-fugacity-model-simulation
#4
Hongwei Ke, Mian Chen, Mengyang Liu, Meng Chen, Mengshan Duan, Peng Huang, Jiajun Hong, Yan Lin, Shayen Cheng, Xuran Wang, Mengxue Huang, Minggang Cai
Polycyclic aromatic hydrocarbons (PAHs) have accumulated ubiquitously inArctic environments, where re-volatilization of certain organic pollutants as a result of climate change has been observed. To investigate the fate of semivolatile organic compounds in the Arctic, dissolved PAHs in the surface seawaters from the temperate Pacific Ocean to the Arctic Ocean, as well as a water column in the Arctic Ocean, were collected during the 4th Chinese National Arctic Research Expedition in summer 2010. The total concentrations of seven dissolved PAHs in surface water ranged from 1...
June 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/28651315/linking-potential-nitrification-rates-nitrogen-cycling-genes-and-soil-properties-after-remediating-the-agricultural-soil-contaminated-with-heavy-metal-and-fungicide
#5
Manyun Zhang, Shahla Hosseini Bai, Li Tang, Yaling Zhang, Ying Teng, Zhihong Xu
Apart from the contaminant removal, the remediation of agricultural soil should also pay more attention to soil nutrient retention and biogeochemical cycling. This study aimed to evaluate changes of soil properties, potential nitrification rates (PNRs), and functional gene abundances and link their relationships after remediating co-contaminated agricultural soil with Medicago sativa L. (alfalfa) planting, alone or together with biochar application. Compared with the control (CK), alfalfa planting, alone or together with biochar application, could significantly increase soil organic matter (SOM) contents and discrepantly affect soil pH values...
June 19, 2017: Chemosphere
https://www.readbyqxmd.com/read/28651314/stabilization-of-heavy-metals-in-soil-using-two-organo-bentonites
#6
Kai Yu, Jian Xu, Xiaohong Jiang, Cun Liu, Wesley McCall, Jinlong Lu
Stabilization of Cu, Zn, Cd, Hg, Cr and As in soil using tetramethylammonium (TMA) and dodecyltrimethylammonium (DTMA) modified bentonites (T-Bents and D-Bents) as amendments was investigated. Toxicity characteristic leaching procedure (TCLP) was used to quantify the metal mobility after soil treatment. The structural parameters of modified bentonites, including the BET surface area, basal spacing and zeta potential were obtained as a function of the TMA and DTMA loading at 40, 80, 120, 160 and 200% of the bentonite's cation exchange capacity, respectively...
June 20, 2017: Chemosphere
https://www.readbyqxmd.com/read/28651313/defect-engineered-oxides-for-enhanced-mechanochemical-destruction-of-halogenated-organic-pollutants
#7
Giovanni Cagnetta, Jun Huang, Mengnan Lu, Bin Wang, Yujue Wang, Shubo Deng, Gang Yu
Mechanochemical activation of metal oxides is studied by a novel methodology based on solid state reaction with a stable radical specie. Such approach corroborates that vacancy formation by high energy ball milling, also in nonreducible oxides, is responsible for electron release on particles' surfaces. This finding suggests a new defect engineering strategy to improve effectiveness of metal oxides as co-milling reagent for halogenated organic pollutant destruction. Results prove that high valent metal doping of a commonly employed co-milling reagent such as CaO determines 2...
June 19, 2017: Chemosphere
https://www.readbyqxmd.com/read/28651263/quality-and-dose-optimized-ct-trauma-protocol-recommendation-from-a-university-level-i-trauma-center
#8
Johannes Kahn, David Kaul, Georg Böning, Roman Rotzinger, Patrick Freyhardt, Philipp Schwabe, Martin H Maurer, Diane Miriam Renz, Florian Streitparth
Purpose As a supra-regional level-I trauma center, we evaluated computed tomography (CT) acquisitions of polytraumatized patients for quality and dose optimization purposes. Adapted statistical iterative reconstruction [(AS)IR] levels, tube voltage reduction as well as a split-bolus contrast agent (CA) protocol were applied. Materials and Methods 61 patients were split into 3 different groups that differed with respect to tube voltage (120 - 140 kVp) and level of applied ASIR reconstruction (ASIR 20 - 50 %)...
June 26, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28651261/evaluation-of-the-value-of-contrast-enhanced-ultrasound-ceus-within-radiology-departments-in-germany
#9
Tilmann Graeter, Wolfgang Kratzer, Thomas Seufferlein, Suemeyra Tasdemir, Aylin Senguel, Julian Schmidberger, Hartmut Graeter, Christian Stroszczynski, Meinrad Beer
Purpose Contrast-enhanced ultrasound (CEUS) has been established for many years and has become an increasingly important cornerstone of the diagnostic imaging of various organ systems. However, this modality is rarely performed by radiologists and is primarily employed by other medical disciplines. The goal of this questionnaire study is to present the current value of CEUS in radiology and to encourage reevaluation of the method within this medical discipline. Materials and Methods 560 directors of radiology departments throughout Germany were contacted and given a 3-page questionnaire...
June 26, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28651241/al-based-metal-organic-gels-for-selective-fluorescence-recognition-of-hydroxyl-nitro-aromatic-compounds
#10
Mao Xia Guo, Liu Yang, Zhong Wei Jiang, Zhe Wei Peng, Yuan Fang Li
The novel class of luminescent Al(3+)-based metal-organic gels (Al-MOGs) have been developed by mix 4-[2,2':6',2″-terpyridine]-4'-ylbenzoic acid (Hcptpy) with Al(3+) under mild condition. The as-prepared Al-MOGs have not only multiple stimuli-responsive properties, but selective recognition of hydroxyl nitro aromatic compounds, which can quench the fluorescence of the Al-MOGs, while other nitro aromatic analogues without hydroxyl substitutes cannot. The fluorescence of Al-MOGs at 467nm was seriously quenched by picric acid (PA) whose lowest unoccupied molecular orbital (LUMO) energy levels are lower than those of three other hydroxyl nitro aromatic compounds including 4-nitrophenol (4-NP), 3,5-dinitrosalicylic acid (3,5-DNTSA) and 2,4-dinitrophenol (2,4-DNP)...
May 27, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28651223/impact-of-wastewater-derived-dissolved-interfering-compounds-on-growth-enzymatic-activity-and-trace-organic-contaminant-removal-of-white-rot-fungi-a-critical-review
#11
REVIEW
Muhammad B Asif, Faisal I Hai, Jingwei Hou, William E Price, Long D Nghiem
White-rot fungi (WRF) and their ligninolytic enzymes have been investigated for the removal of a broad spectrum of trace organic contaminants (TrOCs) mostly from synthetic wastewater in lab-scale experiments. Only a few studies have reported the efficiency of such systems for the removal of TrOCs from real wastewater. Wastewater derived organic and inorganic compounds can inhibit: (i) WRF growth and their enzyme production capacity; (ii) enzymatic activity of ligninolytic enzymes; and (iii) catalytic efficiency of both WRF and enzymes...
June 23, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28651221/risk-element-immobilization-stabilization-potential-of-fungal-transformed-dry-olive-residue-and-arbuscular-mycorrhizal-fungi-application-in-contaminated-soils
#12
Mercedes García-Sánchez, Tereza Stejskalová, Inmaculada García-Romera, Jiřina Száková, Pavel Tlustoš
The use of biotransformed dry olive residue (DOR) as organic soil amendment has recently been proposed due to its high contents of stabilized organic matter and nutrients. The potential of biotransformed DOR to immobilize risk elements in contaminated soils might qualify DOR as a potential risk element stabilization agent for in situ soil reclamation practices. In this experiment, the mobility of risk elements in response to Penicillium chrysogenum-10-transformed DOR, Funalia floccosa-transformed DOR, Bjerkandera adusta-transformed DOR, and Chondrostereum purpureum-transformed DOR as well as arbuscular mycorrhizal fungi (AMF), Funneliformis mosseae, inoculation was investigated...
June 23, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28651216/ultra-sensitive-suspended-atomically-thin-layered-black-phosphorus-mercury-sensors
#13
Peng Li, Dongzhi Zhang, Chuanxing Jiang, Xiaoqi Zong, Yuhua Cao
The extraordinary properties of black phosphorus (BP) make it a promising candidate for next-generation transistor chemical sensors. However, BP films reported so far are supported on substrate, and substrate scattering drastically deteriorates its electrical properties. Consequentially, the potential sensing capability of intrinsic BP is highly underestimated and its sensing mechanism is masked. Additionally, the optimum sensing regime of BP remains unexplored. This article is the first demonstration of suspended BP sensor operated in subthreshold regime...
June 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28651208/relationship-between-thms-ndma-formation-potential-and-molecular-weight-of-organic-compounds-for-source-and-treated-water-in-shanghai-china
#14
Dong An, Bin Gu, Sainan Sun, Han Zhang, Yanan Chen, Huifeng Zhu, Jian Shi, Jun Tong
Molecular weight (MW) distributions in source and treated water in Shanghai, China were investigated to understand the relationship between trihalomethanes formation potential/N-nitrosodimethylamine formation potential (THMFP/NDMAFP) and dissolved organic carbon (DOC) for different MW ranges (<1K, 1-10K, 10-30K, >30KDa). The result of MW distributions in source water indicated a relationship between THMFP/NDMAFP and DOC such that DOC for <1K and 1-30KDa DOC were linearly related to THMFP and NDMAFP, respectively...
June 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28651202/durable-superamphiphobic-coatings-repelling-both-cool-and-hot-liquids-based-on-carbon-nanotubes
#15
Naihua Zhai, Ling Fan, Lingxiao Li, Junping Zhang
Superamphiphobic coatings have wide potential applications in many fields, however, preparation of superamphiphobic coatings with low sliding angles and high durability is very challenging. Here, we report a facile spray-coating method for the preparation of durable superamphiphobic coatings repelling both cool and hot liquids from polyperfluoroalkylsilane-modified multiwalled carbon nanotubes (MWCNTs@fluoroPOS). The MWCNTs@fluoroPOS suspensions were preparation by hydrolytic condensation of 1H,1H,2H,2H-perfluorodecyltrichlorosilane (PFDTES) and tetraethoxysilane (TEOS) on the surface of MWCNTs...
June 17, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28651196/dancing-to-death-a-case-of-heat-stroke
#16
K Nadesan, Chandra Kumari, Mohd Afiq
Heat stroke is a medical emergency which may lead to mortality unless diagnosed early and treated effectively. Heat stroke may manifest rapidly, hence making it difficult to differentiate it from other clinical causes in a collapsed victim.(1) We are presenting a case report of twelve patients who were admitted to our emergency department from a music festival held on 13-15th of March 2014. They developed complications arising from a combination of severe adverse weather condition, prolonged outdoor physical exertion due to long hours of dancing and drug-use, resulting in heat stroke...
May 4, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28651189/sex-specific-effects-of-difenoconazole-on-the-growth-hormone-endocrine-axis-in-adult-zebrafish-danio-rerio
#17
Miaomiao Teng, Suzhen Qi, Wentao Zhu, Yao Wang, Dezhen Wang, Yang Yang, Hui Li, Chenglong Li, Kai Dong, Chengju Wang
Difenoconazole, as one of the most widely used triazole fungicides, is applied to protect crops, fruits, and vegetables. It has been reported that difenoconazole can enter the environment and impair aquatic organisms, but whether difenoconazole can disrupt the growth hormone (GH) balance in adult zebrafish (Danio rerio) is still unclear. In this study, adult female and male zebrafish were exposed to difenoconazole (0, 5, 50, and 500µg/L) for seven days. The results revealed that the bioaccumulation of difenoconazole and its primary metabolite difenoconazole alcohol in females were both larger than that in males...
June 23, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28651184/computational-study-of-structural-optoelectronic-and-nonlinear-optical-properties-of-dynamic-solid-state-chalcone-derivatives
#18
Aijaz Rasool Chaudhry, Ahmad Irfan, Shabbir Muhammad, Abdullah G Al-Sehemi, R Ahmed, Zhang Jingping
In the present study, we use the state of art density functional theory (DFT) techniques to calculate the structural, optoelectronic and nonlinear optical (NLO) properties for two novel chalcone derivatives. The geometrical structures of chalcone derivatives compound 1 and 2 are optimized using periodic boundary conditions (PBC) in solid-state phase as well as isolated single molecular geometry in the gas phase. The reasonable agreement is found among experimental, solid-state and gas phase single molecular geometries, which provide us, further confidence to explore the potential of above-entitled derivatives as good functional materials for electro-optical applications...
May 29, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28651176/forensic-applications-of-direct-analysis-in-real-time-dart-coupled-to-q-orbitrap-tandem-mass-spectrometry-for-the-in-situ-analysis-of-pigments-from-paint-evidence
#19
Tai-Hung Chen, Shu-Pao Wu
The accurate examination of paint fragments obtained from an accident, such as those obtained from vehicles involved in a hit-and-run case, is often critical in forensic investigations. However, organic pigments are typically minor components of automotive coatings, which makes discrimination difficult. In this study, direct analysis in real time coupled to Q-orbitrap tandem mass spectrometry (DART-MS) was employed to detect a wide range of common organic pigments in vehicle paints. Twelve common organic pigments used in vehicle paints, such as red, yellow, orange, and purple, were tested, and a database was constructed for future examinations of vehicle paint...
June 9, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28651159/health-related-quality-of-life-results-from-the-phase-iii-checkmate-067-study
#20
Dirk Schadendorf, James Larkin, Jedd Wolchok, F Stephen Hodi, Vanna Chiarion-Sileni, Rene Gonzalez, Piotr Rutkowski, Jean-Jacques Grob, C Lance Cowey, Christopher Lao, John Wagstaff, Margaret K Callahan, Michael A Postow, Michael Smylie, Pier Francesco Ferrucci, Reinhard Dummer, Andrew Hill, Fiona Taylor, Javier Sabater, Dana Walker, Srividya Kotapati, Amy Abernethy, Georgina V Long
BACKGROUND: Nivolumab, a monoclonal antibody of immune checkpoint programmed death 1 on T cells (PD-1), combined with ipilimumab, an immune checkpoint cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) inhibitor, as combination therapy on the one hand and nivolumab as monotherapy on the other, have both demonstrated improved efficacy compared with ipilimumab alone in the CheckMate 067 study. However, the combination resulted in a higher frequency of grade 3/4 adverse events (AEs), which could result in diminished health-related quality of life (HRQoL)...
June 22, 2017: European Journal of Cancer
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