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https://www.readbyqxmd.com/read/28323757/the-performance-of-human-papillomavirus-biomarkers-in-predicting-anal-high-grade-squamous-intraepithelial-lesions-in-gay-and-bisexual-men
#1
Fengyi Jin, Jennifer M Roberts, Andrew E Grulich, I Mary Poynten, Dorothy A Machalek, Alyssa Cornall, Samuel Phillips, Deborah Ekman, Ross L Mcdonald, Richard J Hillman, David J Templeton, Annabelle Farnsworth, Suzanne M Garland, Christopher K Fairley, Sepehr N Tabrizi
BACKGROUND: We evaluate the performance of human papillomavirus (HPV) biomarkers in prediction of anal histological high-grade squamous intraepithelial lesions (HSIL) in gay and bisexual men (GBM) in Sydney, Australia. DESIGN: Baseline analysis of a three-year cohort study METHODS:: The Study of the Prevention of Anal Cancer (SPANC) is natural history study of anal HPV infection in GBM aged ≥35 years. All participants completed cytological and histological assessments...
March 18, 2017: AIDS
https://www.readbyqxmd.com/read/28318242/whole-blood-metabolomics-by-1h-nmr-spectroscopy-provides-a-new-opportunity-to-evaluate-coenzymes-and-antioxidants
#2
G A Nagana Gowda, Daniel Raftery
Conventional human blood metabolomics employs serum or plasma and provides a wealth of metabolic information therein. However, this approach lacks the ability to measure and evaluate important metabolites such as coenzymes that are present at high concentrations in red blood cells. As an important alternative to serum/plasma metabolomics, we show here that a simple 1H NMR experiment can simultaneously measure coenzymes and antioxidants in extracts of whole human blood, in addition to the nearly 70 metabolites that were shown to be quantitated in serum/plasma, recently [Anal...
March 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28317088/phase-i-trial-of-the-oral-smoothened-inhibitor-sonidegib-in-combination-with-paclitaxel-in-patients-with-advanced-solid-tumors
#3
A Stathis, D Hess, R von Moos, K Homicsko, G Griguolo, M Joerger, M Mark, C J Ackermann, S Allegrini, C V Catapano, A Xyrafas, M Enoiu, S Berardi, P Gargiulo, C Sessa
Purpose To establish a recommended phase II dose (RP2D) for the oral smoothened inhibitor sonidegib in combination with paclitaxel; secondary objectives include evaluation of safety, tolerability, markers of Hedgehog (Hh) signaling and preliminary antitumor activity. Methods Patients with advanced solid tumors were enrolled in cohorts of escalating sonidegib dose levels (400mg, 600mg and 800mg orally, once daily on days 1-28) in combination with paclitaxel 80 mg/m(2) on days 1, 8 and 15 in 4-weekly cycles. Dose-limiting toxicities (DLTs) were assessed using CTCAE v4...
March 20, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28315811/variant-two-stage-ileal-pouch-anal-anastomosis-an-innovative-and-effective-alternative-to-standard-resection-in-ulcerative-colitis
#4
Jennifer Samples, Krista Evans, Nicole Chaumont, Paula Strassle, Timothy Sadiq, Mark Koruda
BACKGROUND: Ulcerative colitis patients have been historically treated with standard single, two and three stage operative approaches. We perform a variant two-stage procedure beginning with total abdominal colectomy and end ileostomy followed by completion proctectomy and ileal pouch-anal anastomosis without a diverting loop ileostomy. The present study evaluates the effectiveness of this innovative alternative. STUDY DESIGN: Patients with ulcerative colitis admitted to UNC Hospital between 2003 and 2010 for IPAA were eligible for inclusion...
January 28, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28315786/effects-of-bariatric-surgery-on-female-pelvic-floor-disorders
#5
Avner Leshem, Mordechai Shimonov, Hadar Amir, David Gordon, Asnat Groutz
OBJECTIVES: To assess the effect of weight loss on urinary incontinence (UI), pelvic organ prolapse, colorectal-anal complaints and sexual dysfunction among obese women undergoing bariatric surgery. METHODS: 160 consecutive women who underwent bariatric surgery were prospectively enrolled. Four validated questionnaires (ICIQ-UI, BFLUTS-SF, PFDI-20, PISQ-12) were used to evaluate pelvic floor disorders and sexual dysfunction before, and 3-6 months after surgery. RESULTS: 150 participants (mean age 43±12...
March 15, 2017: Urology
https://www.readbyqxmd.com/read/28304326/group-b-streptococcus-colonization-and-hiv-in-pregnancy-a-cohort-study-in-nigeria
#6
R Biobaku Oluwafunmilola, O Olaleye Atinukek, F Adefusi Olorunwa, A Adeyemi Babalola, O Onipede Anthony, M Loto Olabisi, O Imaralu John
BACKGROUND: Group B streptococcus (GBS) is a leading cause of maternal and neonatal infectious morbidity. HIV is prevalent among pregnant women in Nigeria. AIM: To determine the rates of anogenital GBS colonization in our institution and compare GBS colonization rates between HIV positive and negative pregnant women. METHODS: A cross-sectional comparative study was conducted over 6 months. Patients were separated according to their HIV status: positive and negative...
March 16, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28304143/anal-function-after-endoluminal-loco-regional-resection-by-transanal-endoscopic-microsurgery-and-radiotherapy-for-rectal-cancer
#7
Ivano Biviano, Andrea Balla, Danilo Badiali, Silvia Quaresima, Giancarlo D'Ambrosio, Emanuele Lezoche, Enrico Corazziari, Alessandro M Paganini
AIM: In patients with rectal cancer, surgery and chemo-radiotherapy may affect the anal sphincter function. Few studies evaluated the ano-rectal function after neoadjuvant chemo-radiotherapy (n-CRT) and/or Transanal Endoscopic Microsurgery (TEM). The aim of this study was to evaluate the effects of n-CRT and TEM on ano-rectal function. METHOD: Thirty-seven patients with rectal cancer underwent ano-rectal manometry and Wexner score for faecal incontinence at baseline, after n-CRT (cT2-T3N0 cancer) and at 4 and 12 months after surgery...
March 17, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28302173/squamous-cell-carcinoma-arising-from-chronic-sacrococcygeal-pilonidal-disease-a-case-report
#8
Nick Michalopoulos, Konstantinos Sapalidis, Styliani Laskou, Evangelia Triantafyllou, Georgia Raptou, Isaak Kesisoglou
BACKGROUND: Sacrococcygeal pilonidal disease is a chronic, well-recognized entity, characterized by the recurrent formation of an abscess or draining sinus over the sacrococcygeal area. It is one of the most common surgical problems. Rarely, chronic inflammation and recurrent disease leads to malignant transformation, most commonly to squamous cell carcinoma (SCC). CASE PRESENTATION: We describe an extremely unusual case of SCC developing in a 60-year-old patient with a chronic pilonidal sinus complicated by an anal fistula...
March 17, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28301946/target-population-for-the-screening-of-human-papillomavirus-hpv-and-anal-carcinoma-precursor-lesions-results-from-a-pilot-study-in-hiv-infected-males-with-sexual-risk-factors
#9
Carlos Pastor, Alfonso Cabello Úbeda
Ninety-five percent of precursor lesions -high-grade squamous intraepithelial lesions (HSIL) and anal intraepithelial neoplasms (AIN)- and their progression to squamous anal cancer (AC) are induced by high-risk HPV (HR-HPV) serotypes 16 and 18. Their incidence is higher particularly in HIV-infected male patients who have sex with other males (HIV-MSM) (144/100,000/patients/year).
March 17, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28301430/etiopathogenesis-of-nephrolithiasis-in-ulcerative-colitis-patients-with-the-ileal-pouch-anal-anastomosis
#10
Zubin Arora, Saurabh Mukewar, Rocio Lopez, Debra Camino, Bo Shen, Phillip Hall
BACKGROUND: Our previous study showed that nephrolithiasis is a common complication in ulcerative colitis patients after ileal pouch anal anastomosis (IPAA). However, the pathogenesis of nephrolithiasis in IPAA patients has not been studied. The aim of this study was to compare urine and serum metabolic compositions in IPAA patients with nephrolithiasis and controls with IPAA and no nephrolithiasis. METHODS: Using cross-sectional study design, serum and 24-hour urine metabolic compositions were compared between IPAA patients with nephrolithiasis (the study group) and those without (the control group)...
March 15, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28301429/results-at-up-to-30-years-after-ileal-pouch-anal-anastomosis-for-chronic-ulcerative-colitis
#11
Amy L Lightner, Kellie L Mathis, Eric J Dozois, Dieter Hahnsloser, Edward V Loftus, Laura E Raffals, John H Pemberton
BACKGROUND: Ileal pouch-anal anastomosis (IPAA) has become the surgical procedure of choice for patients with chronic ulcerative colitis. No study to date has examined functional and quality-of-life outcomes 30 years after pouch construction. METHODS: Using data from a prospectively maintained database with annually distributed questionnaires, functional outcomes, pouch complications, and quality of life after IPAA were determined. RESULTS: Overall, 93...
March 15, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28294676/-treatment-results-of-patients-with-rectum-tumor-in-a-city-hospital
#12
Zoltán Banai, Béla Lestár, Lajos Berczi, József Földi, Zsigmond Harkai, Tibor Karácsony
INTRODUCTION: Two hundred and three patients were operated on with rectal malignancy between 2007 and 2014 in our surgical department. METHODS: Of these, patients who had cancer within 16 cm of the anal verge were included. 73 patients received neoadjuvant treatment and 130 patients were treated with primary resection. The specimens were graded by the Dworak and the Rödel regression score system. RESULTS: We found strong response in 45 patients and pathologic complete remission in three patients...
March 2017: Magyar Sebészet
https://www.readbyqxmd.com/read/28293746/long-standing-crohn-s-disease-and-its-implication-on-anal-squamous-cell-cancer-management
#13
Amy L Lightner, Sara B Moncrief, Thomas C Smyrk, John H Pemberton, Michael G Haddock, David W Larson, Eric J Dozois, Kellie L Mathis
BACKGROUND: Anal squamous cell carcinoma (ASCC) is rare, accounting for only 1% of gastrointestinal malignancies. We sought to better understand management strategies for ASCC in the setting of Crohn's disease (CD). METHODS: A retrospective chart review from 2001 to 2016 was conducted using ICD-9/10 codes for CD (555.9/K50) and ASCC (154.3/C44.520). Adult patients with a diagnosis of CD at the time of ASCC diagnosis were included. RESULTS: Seven patients (five female) were included with a median age of 50 years...
March 14, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28292518/the-management-of-penetrating-rectal-and-anal-trauma-a-systematic-review
#14
Daniel P Ahern, Michael E Kelly, Danielle Courtney, Emanuele Rausa, Des C Winter
INTRODUCTION: Traumatic injuries to the lower gastrointestinal tract (rectum and anus) have been largely reported in the military setting with sparse publications from the civilian setting. Additionally, there remains a lack of international consensus regarding definitive treatment pathways. This systematic review aimed to assess the current literature and propose a standardised treatment algorithm to aid management in the civilian setting. METHODS: A systematic review of available literature from 1999 to 2016 that was performed...
March 7, 2017: Injury
https://www.readbyqxmd.com/read/28291401/pelvic-insufficiency-fracture-pif-incidence-in-patients-treated-with-intensity-modulated-radiation-therapy-imrt-for-gynaecological-or-anal-cancer-single-institution-experience-and-review-of-the-literature
#15
Louis Bazire, Haoping Xu, Jean-Philippe Foy, Malika Amessis, Caroline Malhaire, Kim Cao, Anne De La Rochefordiere, Youlia M Kirova
OBJECTIVE: To summarize the results of pelvic insufficiency fracture (PIF) incidence in patients with anal or gynaecological cancer treated by pelvic intensity-modulated radiation therapy (IMRT). METHODS: The clinical and morphological (CT and/or pelvic MRI) characteristics of patients treated by IMRT at our institution between 2007 and 2014 were analyzed. The global incidence of PIF after external beam radiotherapy and the impact of tumour site (gynaecological or anal cancer) were determined...
March 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28291300/-possible-relation-between-antenatal-venlafaxine-use-and-vacterl-association-in-a-newborn-a-case-report
#16
Muammer Özgür Çevik, Mustafa Çelik, İbrahim Hakan Bucak, Behice Han Almış, Mehmet Turğut
Major depressive disorder is common during antenatal period and many women are prescribed antidepressant drugs despite no antidepressant can be regarded as definitely safe in pregnancy. Previous studies have suggested links between gestational use of selective serotonin reuptake inhibitors (SSRI) or serotonin and norepinephrine reuptake inhibitors (SNRI) and certain birth defects. VACTERL association is a rare group of congenital malformations which were observed to occur together more often than would be expected by chance...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28290968/management-of-post-traumatic-rectovesical-rectourethral-fistulas-case-series-of-complicated-injuries-in-wounded-warriors-and-review-of-the-literature
#17
Walter B Kucera, James R Jezior, James E Duncan
INTRODUCTION: Penetrating injuries to the pelvis and perineum can result in fistulas between the rectum and lower urinary tract. These injuries are often complicated, which creates challenges for successful repair. Operative strategies may include initial fecal and/or urinary diversion combined with an eventual trans-perineal, trans-anal, or posterior/transrectal approach, but the selected approach should be guided by precise anatomic localization of the injury. We aim to discuss different possible repair strategies as well as the relevant data surrounding gastrointestinal-genitourinary (GI-GU) fistula management...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28290108/some-improvements-in-confidence-intervals-for-standardized-regression-coefficients
#18
Paul Dudgeon
Yuan and Chan (Psychometrika 76:670-690, 2011. doi: 10.1007/S11336-011-9224-6 ) derived consistent confidence intervals for standardized regression coefficients under fixed and random score assumptions. Jones and Waller (Psychometrika 80:365-378, 2015. doi: 10.1007/S11336-013-9380-Y ) extended these developments to circumstances where data are non-normal by examining confidence intervals based on Browne's (Br J Math Stat Psychol 37:62-83, 1984. doi: 10.1111/j.2044-8317.1984.tb00789.x ) asymptotic distribution-free (ADF) theory...
March 13, 2017: Psychometrika
https://www.readbyqxmd.com/read/28289973/a-novel-laparoscopic-technique-for-anorectal-malformation-with-low-recto-bulbar-fistulae
#19
Mei Diao, Long Li, Kao-Ping Guan, Zhen Zhang, Wei Cheng
BACKGROUND: The repair of anorectal malformation (ARM) with low recto-bulbar fistula (bowel-to-skin distance: 1-1.5 cm) is contraindicated for laparoscopy due to the difficulty in exposing the fistulae. Posterior or anterior sagittal anorectoplasty is thus conventionally carried out for low recto-bulbar fistula repair. However, these procedures carry the potential risk of wound infection/dehiscence and incontinence. We have developed a single-incision laparoscopic-assisted perineal anorectoplasty (SILPARP) technique...
March 13, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28289834/the-impact-of-anastomotic-leakage-on-anal-function-following-intersphincteric-resection
#20
Mitsuru Yokota, Masaaki Ito, Yuji Nishizawa, Akihiro Kobayashi, Norio Saito
BACKGROUND: Data regarding anastomotic leakage (AL) following intersphincteric resection (ISR) are lacking. We aimed to evaluate the effect of AL on anal function in a retrospective review of patients who developed AL following ISR. METHODS: We evaluated 341 consecutive patients who underwent ISR between 2000 and 2012. Patients were classified into three groups: anastomotic dehiscence (AD), major AL (Clavien-Dindo grade III+), or control (<grade III or no AL)...
March 13, 2017: World Journal of Surgery
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