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https://www.readbyqxmd.com/read/29236293/real-time-pcr-to-evaluate-hsv-2-shedding-from-anal-and-genital-samples-among-men-who-have-sex-with-men-living-with-hiv
#1
Dayana Nicté Vergara-Ortega, Edgar Enrique Sevilla-Reyes, Antonia Herrera-Ortiz, Leticia Torres-Ibarra, Jorge Salmerón, Eduardo Lazcano-Ponce, Miguel Angel Sánchez-Alemán
This study shows the relative quantification of HSV-2 by qPCR, using the MIQE Guidelines. The reaction efficiency was evaluated, and the relative quantification used the R=2-ΔCq method. The relative quantification of HSV-2 was conducted with anal and genital samples from men who have sex with men (MSM), living with HIV. The presence of a single amplification product was validated with a dissociation curves profile and the determination of the melting temperature. The limit of detection for β-globin was determined as 3...
December 13, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29235691/rna-interference-mediated-functional-characterization-of-aquaporin-genes-in-tribolium-castaneum
#2
X-X Yao, Q-W Meng, G-Q Li
An obvious challenge faced by most terrestrial insects is maintaining water homeostasis in an arid environment. Current research suggests aquaporins may be evolved to meet the challenge. However, up to now, this suggestion has not been verified in any insect that feeds upon solid food with mandibulate mouthparts. In the present paper, nine putative aquaporin genes [Tribolium castaneum big brain, T. castaneum Drosophila integral protein (TcDrip), T. castaneum Pyrocoelia rufa integral protein (TcPrip), T. castaneum aquaporin 12-like, T...
December 13, 2017: Insect Molecular Biology
https://www.readbyqxmd.com/read/29234962/the-functional-outcome-and-factors-influencing-the-quality-of-life-after-ileal-pouch-anal-anastomosis-in-patients-with-ulcerative-colitis
#3
Kazuhiro Watanabe, Munenori Nagao, Hideyuki Suzuki, Hideaki Karasawa, Shinobu Ohnuma, Hiroaki Musha, Yuji Funayama, Takashi Kamei, Takeshi Naitoh, Michiaki Unno
PURPOSE: The aim of this study was to assess the bowel function and quality of life (QOL) in patients with ulcerative colitis (UC) after total proctocolectomy with ileal pouch anal anastomosis (IPAA). METHODS: Two questionnaires ["Questionnaire sheet on the bowel function" and "Inflammatory bowel disease questionnaire (Japanese IBDQ)"] were sent to 121 patients with UC who underwent IPAA at Tohoku University Hospital. Seventy-nine patients (65%) participated in the study...
December 12, 2017: Surgery Today
https://www.readbyqxmd.com/read/29234945/clinical-significance-and-functional-validation-of-inorganic-pyrophosphatase-in-diffuse-large-b-cell-lymphoma-in-humans
#4
Limei Li, Aruna, Dehong Luo, Arong Jin
Diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin's lymphoma, displays marked heterogeneity. Although it is usually curable, 30-40% of patients die within 1-2 years due to refractory treatment or cancer relapse. In different types of cancer in humans, inorganic pyrophosphatase (PPA1) is deregulated, thereby contributing to tumorigenesis by supplying the tumor with an enormous energy source. However, the role of PPA1 in DLBCL is still unclear. Here, we analized PPA1 in 65 patients with DLBCL and 20 patients with reactive hyperplasia of the lymph nodes (control)...
December 12, 2017: Cytotechnology
https://www.readbyqxmd.com/read/29234923/non-inferiority-multicenter-prospective-randomized-controlled-study-of-rectal-cancer-t2-t3s-superficial-n0-m0-undergoing-neoadjuvant-treatment-and-local-excision-tem-vs-total-mesorectal-excision-tme
#5
X Serra-Aracil, C Pericay, T Golda, L Mora, E Targarona, S Delgado, A Reina, F Vallribera, J M Enriquez-Navascues, S Serra-Pla, J C Garcia-Pacheco
PURPOSE: The standard treatment of rectal adenocarcinoma is total mesorectal excision (TME), in many cases requires a temporary or permanent stoma. TME is associated with high morbidity and genitourinary alterations. Transanal endoscopic microsurgery (TEM) allows access to tumors up to 20 cm from the anal verge, achieves minimal postoperative morbidity and mortality rates, and does not require an ostomy. The treatment of T2, N0, and M0 cancers remains controversial. Preoperative chemoradiotherapy (CRT) in association with TEM reduces local recurrence and increases survival...
December 12, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29233787/anal-advancement-flap-versus-lateral-internal-sphincterotomy-for-chronic-anal-fissure-a-systematic-review-and-meta-analysis
#6
REVIEW
Shaheel Mohammad Sahebally, Stewart Redmond Walsh, Waqas Mahmood, Thomas Michael Aherne, Myles Richard Joyce
BACKGROUND: Chronic anal fissures (CAF) are common and associated with reduced quality of life. Lateral internal sphincterotomy (LIS) is frequently carried out but carries a significant risk of anal incontinence. Anal advancement flap (AAF) has been advocated as an alternative, 'sphincter-preserving' procedure. We aimed to perform a systematic review and meta-analysis to compare the efficacy of both techniques in the treatment of CAF. METHODS: The online databases of PubMed/Medline, CINAHL, EMBASE and Cochrane Central Register of Controlled Trials were searched from inception to January 2017...
December 9, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29232767/a-comparative-immunohistochemical-study-of-anal-canal-epithelium-in-humans-and-swine-focusing-on-the-anal-transitional-zone-epithelium-and-the-anal-glands
#7
Futoshi Muranaka, Tomoyuki Nakajima, Mai Iwaya, Keiko Ishii, Kayoko Higuchi, Naoko Ogiwara, Shinichi Miyagawa, Hiroyoshi Ota
To better understand the cellular origins and differentiation of anal canal epithelial neoplasms, the immunohistochemical profiles of the anal canal epithelium in humans and swine were evaluated. Formalin-fixed tissue sections were immunostained for mucin (MUC: MUC2, MUC5AC, MUC5B), desmoglein 3 (DGS3), p63, CDX2, SOX2, and α-smooth muscle actin (α-SMA). The anal transitional zone (ATZ) epithelium covered the anal sinus and consisted of a stratified epithelium with mucous cells interspersed within the surface lining...
December 12, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29232533/laparoscopic-abdominal-transanal-proctocolectomy-with-coloanal-anastomosis-is-a-good-surgical-option-in-selective-patients-with-low-lying-rectal-cancer-a-retrospective-analysis-based-on-a-single-surgeon-s-experience
#8
Bong-Hyeon Kye, Jun-Gi Kim, Hyeon-Min Cho, Hyung-Jin Kim, Chung-Soo Chun
PURPOSE: We intended to identify the oncological outcome for rectal cancer over the past 20 years and whether or not sphincter-preserving surgery is an appropriate approach for low-lying rectal cancer. MATERIALS AND METHODS: The oncological outcomes from a total of 418 patients who electively underwent rectal cancer surgery for a lesion located within 8 cm of the anal verge by a single colorectal surgeon were reviewed retrospectively. RESULTS: Of 418 patients, 175 patients underwent low anterior resection (LAR), 172 laparoscopic abdominal transanal proctocolectomy with coloanal anastomosis (LATA), and 71 abdominoperineal resection (APR)...
December 12, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29232170/correlates-of-never-testing-for-hiv-among-sexually-active-internet-recruited-gay-bisexual-and-other-men-who-have-sex-with-men-in-the-united-states
#9
Kimberly M Nelson, David W Pantalone, Kristi E Gamarel, Michael P Carey, Jane M Simoni
In the United States, gay, bisexual, and other men who have sex with men (GBMSM) are disproportionately affected by the HIV/AIDS epidemic. Despite great strides in HIV prevention, including biobehavioral HIV prevention strategies such as pre-exposure prophylaxis and treatment as prevention, there has been relatively low uptake of these strategies. The success of biobehavioral prevention strategies requires HIV testing but a subset of GBMSM have never been tested. To optimize prevention efforts, we sought to understand the characteristics of GBMSM who report never testing for HIV...
December 12, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29232005/x-linked-vacterl-h-caused-by-deletion-of-exon-3-in-fancb-a-case-report
#10
Norikazu Watanabe, Seiji Tsutsumi, Yuki Miyano, Hidenori Sato, Satoru Nagase
VACTERL is a congenital malformation characterized by vertebral defects (V), anal atresia (A), cardiac malformation (C), tracheoesophageal fistula (T), esophageal atresia (E), radial or renal dysplasia (R), and limb abnormalities (L) (McCauley et al. 2011). An association of VACTERL with ventriculomegaly or clinical hydrocephalus, known as VACTERL-H, was reported to have poor prognosis. Here, we report a case of VACTERL-H with an X-linked family history and a deleted exon 3 in FANCB.
December 12, 2017: Congenital Anomalies
https://www.readbyqxmd.com/read/29231588/-acupoint-catgut-embedding-therapy-in-treatment-of-anal-fissure-at-%C3%A2-and-%C3%A2-stages-a-randomized-controlled-trial
#11
Songhua Deng, Li Mo, Wenwen Deng, Sai Chen, Yongheng He
OBJECTIVE: To evaluate the difference in the clinical therapeutic effects on anal fissure at Ⅰ and Ⅱ stages between the acupoint catgut embedding therapy and western medication. METHODS: Sixty patients of anal fissure at Ⅰ and Ⅱ stages were randomized into an embedding therapy group and a western medication group, 30 cases in each one. In the embedding therapy group, the acupoint catgut embedding therapy was applied at bilateral Tianshu (ST 25), Changqiang (GV 1), bilateral Chengshan (BL 57) and Tigangxue (Extra), once a week...
April 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231549/-mechanism-of-acupoint-transcutaneous-electric-stimulation-on-analgesic-anesthesia-in-the-patients-undergoing-general-anesthesia-anorectal-operation
#12
Yufang Lin, Wei Yang, Yajuan Li, Yin Li, Qiuyu Tong, Wen Ma, Yijing Li, Weidong Shen
OBJECTIVE: To observe the regulatory effects of acupoint electric stimulation on the analgesic substances and the relevant indices of nerve-immunity-endocrine system in the patients undergoing general anesthesia anorectal operation. METHODS: One hundred and fifty-six patients undergoing hemorrhoids and anal fistula operation were randomized into three groups, 146 cases were included in the analysis. In the No.1 group (48 cases), the conventional intravenous general anesthesia was applied...
July 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29230964/preventive-effect-of-diverting-stoma-on-anastomotic-leakage-after-laparoscopic-low-anterior-resection-with-double-stapling-technique-reconstruction-applied-based-on-risk-stratification
#13
Atsushi Hamabe, Masaaki Ito, Hideaki Nishigori, Yuji Nishizawa, Takeshi Sasaki
INTRODUCTION: During laparoscopic low anterior resection with double stapling technique reconstruction, it is necessary to securely implement rectal transection and anastomosis to prevent anastomotic leakage (AL). However, risk factors and preventive measures for AL are not known sufficiently. Therefore, this study aimed to elucidate risk factors associated with AL and to clarify strategies to prevent it. METHODS: We analyzed a total of 296 cases with rectal cancer who had undergone laparoscopic low anterior resection with double stapling technique reconstruction at the National Cancer Center Hospital East...
December 12, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29229485/the-position-of-the-anal-dimple-in-newborns-and-infants-with-anorectal-malformations-and-its-correlation-with-the-normal-anal-position
#14
Jigar N Patel, Amit Kumar, Partap Singh Yadav, Rajiv Chadha, Vikram Datta, Subhasis Roy Choudhury
BACKGROUND/PURPOSE: The anal position index (API) defines the normal anal position as the ratio of fourchette-anal distance to fourchette-coccyx distance for females and the scrotum-anal distance to scrotum-coccyx distance for males. In this study, measurement of the API in newborns and infants with anorectal malformations (ARM), using the center of the midline anal dimple (AD) to represent the center of the proposed neoanus, was performed to assess whether or not the AD was located in a significantly abnormal position as correlated with the normal anal position...
November 16, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29228753/the-best-surgical-strategy-for-anal-fistula-based-on-a-network-meta-analysis
#15
Qi Wang, Yukun He, Jun Shen
Objective: To determine a superior surgical treatment for anal fistula through a network meta-analysis and to provide the best direction for development in this field. Methods: We conducted a systematic literature search of the PubMed, Embase and Cochrane Library databases and extracted data from randomized controlled trials, which compared healing time, incontinence and recurrence associated with surgical strategies for anal fistula. A network meta-analysis was conducted using ADDIS software by evaluating the 3 parameters...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29224507/three-anastomotic-techniques-following-laparoscopic-rectal-cancer-resection-our-experience-in-155-patients
#16
Mahtab Zanguie, Abbas Abdollahi, Roham Salek, Ali Jangjoo, Mehdi Jabbari Nooghabi, Hosein Shabahang, Hamed Golmohammadzadeh
PURPOSE: This study aimed to assess the impact of 3 anastomotic techniques after laparoscopic rectal cancer resection. METHODS: In a cross-sectional study, the data of 155 patients who underwent surgery for rectal cancer were retrieved. An anastomosis was created between the left colon and anal canal with 3 different methods: coloanal anastomosis with protective ileostomy (group A), coloanal anastomosis without ostomy (group B), and delayed coloanal anastomosis (group C)...
December 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/29224068/hi-plex-for-simple-accurate-and-cost-effective-amplicon-based-targeted-dna-sequencing
#17
Bernard J Pope, Fleur Hammet, Tu Nguyen-Dumont, Daniel J Park
Hi-Plex is a suite of methods to enable simple, accurate, and cost-effective highly multiplex PCR-based targeted sequencing (Nguyen-Dumont et al., Biotechniques 58:33-36, 2015). At its core is the principle of using gene-specific primers (GSPs) to "seed" (or target) the reaction and universal primers to "drive" the majority of the reaction. In this manner, effects on amplification efficiencies across the target amplicons can, to a large extent, be restricted to early seeding cycles. Product sizes are defined within a relatively narrow range to enable high-specificity size selection, replication uniformity across target sites (including in the context of fragmented input DNA such as that derived from fixed tumor specimens (Nguyen-Dumont et al...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29223761/chemsex-risk-behaviours-and-sexually-transmitted-infections-among-men-who-have-sex-with-men-in-dublin-ireland
#18
Ronan W Glynn, Niamh Byrne, Siobhan O'Dea, Adam Shanley, Mary Codd, Eamon Keenan, Mary Ward, Derval Igoe, Susan Clarke
BACKGROUND: Drug use for or during sex ('chemsex') among MSM has caused concern, because of the direct effects of the drugs themselves, and because of an increased risk of transmission of sexually transmitted infections (STIs). This study aimed to assess the prevalence of chemsex, associated behaviours and STIs among attendees at Ireland's only MSM-specific sexual health clinic in Dublin over a six week period in 2016. METHODS: The questionnaire collected demographic data, information on sexuality and sexual practice, self-reported history of treatment for STIs, and chemsex use...
December 7, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29221209/direct-hpv-e6-myc-interactions-induce-histone-modifications-pol-ii-phosphorylation-and-htert-promoter-activation
#19
Yiyu Zhang, Aleksandra Dakic, Renxiang Chen, Yuhai Dai, Richard Schlegel, Xuefeng Liu
Human Papillomavirus Viruses (HPVs) are associated with the majority of human cervical and anal cancers and 10-30% of head and neck squamous carcinomas. E6 oncoprotein from high risk HPVs interacts with the p53 tumor suppressor protein to facilitate its degradation and increases telomerase activity for extending the life span of host cells. We published previously that the Myc cellular transcription factor associates with the high-risk HPV E6 protein in vivo and participates in the transactivation of the hTERT promoter...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220586/co-occurring-psychosocial-problems-and-multiple-sexual-partners-among-men-who-have-sex-with-men-in-shanghai-china-a-syndemic-approach
#20
Zezhou Wang, Xu Zhao, Zhan Zhang, Mengyun Luo, Qiuming Shen, Yuanyuan Dong, Ying Wang, Yong Cai
We aimed to apply syndemic theory to verify the association and reinforcing effects between psychosocial problems and multiple sexual partners (MSP) of men who have sex with men (MSM) in Shanghai, China. A cross-sectional study was conducted among 547 MSM in Shanghai, China using a face-to-face survey. Sociodemographic and psychosocial data were collected, as well as information on MSP and condomless anal sex. In the 6 months prior to the survey, 54.3% of the MSM sample had had MSP. Univariate analysis showed that self-esteem, depression, loneliness, sexual compulsivity, and involuntary subordination (IS) were associated with MSP...
December 8, 2017: Journal of Sex Research
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