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https://www.readbyqxmd.com/read/28922810/a-shock-and-awe-thioridazine-and-moxifloxacin-combination-based-regimen-for-pulmonary-mycobacterium-avium-intracellulare-complex-disease
#1
Shashikant Srivastava, Devyani Deshpande, Carleton M Sherman, Tawanda Gumbo
Objectives: To develop a thioridazine/moxifloxacin-based combination regimen for treatment of pulmonary infection due to Mycobacterium avium-intracellulare complex (MAC) that kills bacteria faster than the standard treatment regimen. Methods: Monocytes were infected with MAC and inoculated into the hollow-fibre system model for pulmonary MAC disease (HFS-MAC). We co-administered ethambutol plus azithromycin daily for 28 days, to achieve the same human concentration-time profiles that result from standard doses, in three HFS-MAC systems...
September 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28905174/mathematical-development-and-computational-analysis-of-harmonic-phase-magnetic-resonance-imaging-harp-mri-based-on-bloch-nuclear-magnetic-resonance-nmr-diffusion-model-for-myocardial-motion
#2
Michael O Dada, Babatunde Jayeoba, Bamidele O Awojoyogbe, Uno E Uno, Oluseyi E Awe
Harmonic Phase-Magnetic Resonance Imaging (HARP-MRI) is a tagged image analysis method that can measure myocardial motion and strain in near real-time and is considered a potential candidate to make magnetic resonance tagging clinically viable. However, analytical expressions of radially tagged transverse magnetization in polar coordinates (which is required to appropriately describe the shape of the heart) have not been explored because the physics required to directly connect myocardial deformation of tagged Nuclear Magnetic Resonance (NMR) transverse magnetization in polar geometry and the appropriate harmonic phase parameters are not yet available...
September 13, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28892175/-almost-forgetting-to-care-an-unanticipated-source-of-empathy-loss-in-clerkship
#3
Cheryl L Holmes, Harry Miller, Glenn Regehr
CONTEXT: The erosion of empathy in medical students is well documented. Both the hidden curriculum associated with poor role modelling and a sense of burnout have been proposed as key factors, but the precise mechanisms by which this loss of empathy occurs have not been elaborated. OBJECTIVES: In the context of a course designed to help students manage the hidden curriculum, we collected data that raised questions about current conceptualisations of the aspects of medical training that lead to loss of empathy...
July 2017: Medical Education
https://www.readbyqxmd.com/read/28879889/predictors-of-quality-of-life-among-adolescents-with-epilepsy-in-the-state-of-andhra-pradesh
#4
M Nagarathnam, B Shalini, V Vijayalakshmi, B Vengamma, S A A Latheef
OBJECTIVES: Assessment of quality of life (QOL) reveals the impact of diseases and factors responsible for the impairment of quality of life. The purpose of this study was to evaluate the QOL among adolescents with epilepsy (AWE) in the state of Andhra Pradesh. MATERIALS AND METHODS: One hundred and fifty AWE aged 13-19 years were evaluated for QOL using the Telugu version of the Quality of Life in Epilepsy Inventory for Adolescents (QOLIE) AD-48 and the data were analyzed to predict the factors responsible for determining the QOL...
September 2017: Neurology India
https://www.readbyqxmd.com/read/28874542/self-report-captures-27-distinct-categories-of-emotion-bridged-by-continuous-gradients
#5
Alan S Cowen, Dacher Keltner
Emotions are centered in subjective experiences that people represent, in part, with hundreds, if not thousands, of semantic terms. Claims about the distribution of reported emotional states and the boundaries between emotion categories-that is, the geometric organization of the semantic space of emotion-have sparked intense debate. Here we introduce a conceptual framework to analyze reported emotional states elicited by 2,185 short videos, examining the richest array of reported emotional experiences studied to date and the extent to which reported experiences of emotion are structured by discrete and dimensional geometries...
September 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28857578/awe-and-humility
#6
Jennifer E Stellar, Amie Gordon, Craig L Anderson, Paul K Piff, Galen D McNeil, Dacher Keltner
Humility is a foundational virtue that counters selfish inclinations such as entitlement, arrogance, and narcissism (Tangney, 2000). We hypothesize that experiences of awe promote greater humility. Guided by an appraisal-tendency framework of emotion, we propose that when individuals encounter an entity that is vast and challenges their worldview, they feel awe, which leads to self-diminishment and subsequently humility. In support of these claims, awe-prone individuals were rated as more humble by friends (Study 1) and reported greater humility across a 2-week period (Study 2), controlling for other positive emotions...
August 31, 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28856859/a-comparison-between-high-intensity-focused-ultrasound-and-surgical-treatment-for-the-management-of-abdominal-wall-endometriosis
#7
X Zhu, L Chen, X Deng, S Xiao, M Ye, M Xue
OBJECTIVE: The aim of this study was to compare the therapeutic outcomes of high-intensity focused ultrasound (HIFU) and surgical treatment for abdominal wall endometriosis. DESIGN: A retrospective study. SETTING: Gynaecological department of a teaching hospital in China. POPULATION: Patients with abdominal wall endometriosis. METHODS: Among the 51 patients, 23 patients were treated with ultrasound-guided HIFU and 28 patients with surgery...
August 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28856852/ultrasound-guided-high-intensity-focused-ultrasound-treatment-for-abdominal-wall-endometriosis-a-retrospective-study
#8
S Luo, C Zhang, J P Huang, G H Huang, J He
OBJECTIVE: To evaluate the safety and efficacy of ultrasound-guided high-intensity focused ultrasound (USgHIFU) for treating abdominal wall endometrioses (AWE). DESIGN: A retrospective study. SETTING: Department of Obstetrics and Gynaecology in China. POPULATION: Patients with abdominal wall endometriosis. METHODS: From August 2010 to April 2014, 32 patients with AWE were treated with USgHIFU in our hospital...
August 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28852084/high-altitude-wind-resources-in-the-middle-east
#9
Chak Man Andrew Yip, Udaya Bhaskar Gunturu, Georgiy L Stenchikov
In the Middle East, near-surface wind resources are intermittent. However, high-altitude wind resources are abundant, persistent, and readily available and may provide alternative energy resources in this fossil-fuel-dependent region. Using wind field data from the Modern-Era Retrospective Analysis for Research and Applications Version 2 (MERRA-2), this study identifies areas favorable to the deployment of airborne wind energy (AWE) systems in the Middle East and computes the optimal heights at which such systems would best operate...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28833075/accuracy-of-50-g-glucose-challenge-test-to-detect-international-association-of-diabetes-and-pregnancy-study-groups-criteria-defined-hyperglycemia
#10
Biodun N Olagbuji, Adeniyi K Aderoba, Oluwatosin O Kayode, Christianah O Awe, Adesina L Akintan, Yetunde W Olagbuji
OBJECTIVES: To determine the accuracy of the 50-g glucose challenge test (GCT) in detecting hyperglycemia in pregnancy (HIP) across a range of glucose thresholds relative to the International Association of Diabetes and Pregnancy Study Groups diagnostic criteria, and to determine the accuracy of the 50-g GCT among patients with different risk status. METHODS: The present prospective cohort study included women aged 18-45 years at 24-31(+6)  weeks of pregnancy who presented at the Mother and Child Hospital, Akure, Nigeria, between September 1, 2015, and February 29, 2016...
August 21, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28828271/late-pleistocene-songbirds-of-liang-bua-flores-indonesia-the-first-fossil-passerine-fauna-described-from-wallacea
#11
Hanneke J M Meijer, Rokus Awe Due, Thomas Sutikna, Wahyu Saptomo, Jatmiko, Sri Wasisto, Matthew W Tocheri, Gerald Mayr
BACKGROUND: Passerines (Aves: Passeriformes) dominate modern terrestrial bird communities yet their fossil record is limited. Liang Bua is a large cave on the Indonesian island of Flores that preserves Late Pleistocene-Holocene deposits (∼190 ka to present day). Birds are the most diverse faunal group at Liang Bua and are present throughout the stratigraphic sequence. METHODS: We examined avian remains from the Late Pleistocene deposits of Sector XII, a 2 × 2 m area excavated to about 8...
2017: PeerJ
https://www.readbyqxmd.com/read/28804510/the-nonverbal-communication-of-positive-emotions-an-emotion-family-approach
#12
Disa A Sauter
This review provides an overview of the research on nonverbal expressions of positive emotions, organised into emotion families, that is, clusters sharing common characteristics. Epistemological positive emotions (amusement, relief, awe, and interest) are found to have distinct, recognisable displays via vocal or facial cues, while the agency-approach positive emotions (elation and pride) appear to be associated with recognisable visual, but not auditory, cues. Evidence is less strong for the prosocial emotions (love, compassion, gratitude, and admiration) in any modality other than touch, and there is little support for distinct recognisable signals of the savouring positive emotions (contentment, sensory pleasure, and desire)...
July 2017: Emotion Review: Journal of the International Society for Research on Emotion
https://www.readbyqxmd.com/read/28802338/context-in-quality-of-care-improving-teamwork-and-resilience
#13
REVIEW
Daniel S Tawfik, John Bryan Sexton, Kathryn C Adair, Heather C Kaplan, Jochen Profit
Quality improvement in health care is an ongoing challenge. Consideration of the context of the health care system is of paramount importance. Staff resilience and teamwork climate are key aspects of context that drive quality. Teamwork climate is dynamic, with well-established tools available to improve teamwork for specific tasks or global applications. Similarly, burnout and resilience can be modified with interventions such as cultivating gratitude, positivity, and awe. A growing body of literature has shown that teamwork and burnout relate to quality of care, with improved teamwork and decreased burnout expected to produce improved patient quality and safety...
September 2017: Clinics in Perinatology
https://www.readbyqxmd.com/read/28792933/an-early-modern-human-presence-in-sumatra-73-000-63-000-years-ago
#14
K E Westaway, J Louys, R Due Awe, M J Morwood, G J Price, J-X Zhao, M Aubert, R Joannes-Boyau, T M Smith, M M Skinner, T Compton, R M Bailey, G D van den Bergh, J de Vos, A W G Pike, C Stringer, E W Saptomo, Y Rizal, J Zaim, W D Santoso, A Trihascaryo, L Kinsley, B Sulistyanto
Genetic evidence for anatomically modern humans (AMH) out of Africa before 75 thousand years ago (ka) and in island southeast Asia (ISEA) before 60 ka (93-61 ka) predates accepted archaeological records of occupation in the region. Claims that AMH arrived in ISEA before 60 ka (ref. 4) have been supported only by equivocal or non-skeletal evidence. AMH evidence from this period is rare and lacks robust chronologies owing to a lack of direct dating applications, poor preservation and/or excavation strategies and questionable taxonomic identifications...
August 9, 2017: Nature
https://www.readbyqxmd.com/read/28775215/observation-of-coherent-elastic-neutrino-nucleus-scattering
#15
D Akimov, J B Albert, P An, C Awe, P S Barbeau, B Becker, V Belov, A Brown, A Bolozdynya, B Cabrera-Palmer, M Cervantes, J I Collar, R J Cooper, R L Cooper, C Cuesta, D J Dean, J A Detwiler, A Eberhardt, Y Efremenko, S R Elliott, E M Erkela, L Fabris, M Febbraro, N E Fields, W Fox, Z Fu, A Galindo-Uribarri, M P Green, M Hai, M R Heath, S Hedges, D Hornback, T W Hossbach, E B Iverson, L J Kaufman, S Ki, S R Klein, A Khromov, A Konovalov, M Kremer, A Kumpan, C Leadbetter, L Li, W Lu, K Mann, D M Markoff, K Miller, H Moreno, P E Mueller, J Newby, J L Orrell, C T Overman, D S Parno, S Penttila, G Perumpilly, H Ray, J Raybern, D Reyna, G C Rich, D Rimal, D Rudik, K Scholberg, B J Scholz, G Sinev, W M Snow, V Sosnovtsev, A Shakirov, S Suchyta, B Suh, R Tayloe, R T Thornton, I Tolstukhin, J Vanderwerp, R L Varner, C J Virtue, Z Wan, J Yoo, C-H Yu, A Zawada, J Zettlemoyer, A M Zderic
The coherent elastic scattering of neutrinos off nuclei has eluded detection for four decades, even though its predicted cross-section is the largest by far of all low-energy neutrino couplings. This mode of interaction provides new opportunities to study neutrino properties, and leads to a miniaturization of detector size, with potential technological applications. We observe this process at a 6.7-sigma confidence level, using a low-background, 14.6-kg CsI[Na] scintillator exposed to the neutrino emissions from the Spallation Neutron Source (SNS) at Oak Ridge National Laboratory...
August 3, 2017: Science
https://www.readbyqxmd.com/read/28732072/placental-peptides-metabolism-and-maternal-factors-as-predictors-of-risk-of-gestational-diabetes-in-pregnant-women-a-case-control-study
#16
Robert Amadu Ngala, Linda Ahenkorah Fondjo, Peter Gmagna, Frank Naku Ghartey, Martin Akilla Awe
BACKGROUND: Gestational diabetes is a risk factor for perinatal complications; include shoulder dystocia, birth injuries such as bone fractures and nerve palsies. It is associated with later development of type 2 diabetes, the risk of macrosomia and other long-term health effects of infants born to diabetic mothers. The study assesses placental peptides and maternal factors as potential predictors of gestational diabetes among pregnant women. MATERIAL AND METHODS: A total of 200 pregnant women were recruited for the study, 150 pregnant women without pre gestational diabetes including 50 women with low risk factors of diabetes as controls and 50 other pregnant women with pregestational diabetes as control...
2017: PloS One
https://www.readbyqxmd.com/read/28665113/awe-somes-all-water-emulsion-bodies-with-permeable-shells-and-selective-compartments
#17
Sarah D Hann, Kathleen J Stebe, Daeyeon Lee
Living cells exploit compartmentalization within organelles to spatially and temporally control reactions and pathways. Here, we use the all aqueous two phase system (ATPS) of poly(ethylene glycol) (PEG) and dextran to develop all water emulsion bodies, AWE-somes, a new class of encapsulated double emulsions as potential cell mimics. AWE-somes feature rigid polyelectrolyte (PE)/nanoparticle (NP) shells and double emulsion interiors. The shells form via complexation of PE and NP at interfaces of ATPS. The NPs, excluded from the drop phase, create an osmotic stress imbalance that removes water from the encapsulated phase and draws droplets of external PEG phase into the shells to form the double emulsion interior...
July 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28656180/tuning-interfacial-complexation-in-aqueous-two-phase-systems-with-polyelectrolytes-and-nanoparticles-for-compound-all-water-emulsion-bodies-awe-somes
#18
Sarah D Hann, Daeyeon Lee, Kathleen J Stebe
Interfacial complexation between two oppositely charged polymers in aqueous two phase systems (ATPSs) leads to the formation of mechanically robust microcapsules that can be stressed without losing their structural integrity. When a polyelectrolyte (PE) is replaced with a charged nanoparticle (NP), microcapsules with internal compartments can be generated within an encapsulated shell comprising NPs and PEs, named AWE-somes. These shells, made by interfacial complexation between PEs and NPs, are, however, very brittle and can lose their integrity under mechanical stress, potentially limiting their applications...
September 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28653208/-employed-and-self-employed-specialists-in-outpatient-ophthalmological-care-comparison-with-other-specialist-fields
#19
U Hahn, F Kretz, B Awe, J Koch
AIM: The aim of the study was to evaluate the contribution to outpatient care and the perspectives of employed and self-employed ophthalmologists in isolation and in comparison to other professional groups. METHOD: Based on statistical data (source: statistical information provided by the National Association of Statutory Health Insurance Physicians) from 31 December 2015, newly admitted physicians in 2015 and their contribution differentiated by employment relationships were evaluated according to head count and working time equivalents (using "planning of demand equivalents")...
June 26, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28637058/evaluation-of-cases-of-abdominal-wall-endometriosis-at-universidade-estadual-de-campinas-in-a-period-of-10-years
#20
Daniela Angerame Yela, Lucas Trigo, Cristina Laguna Benetti-Pinto
Purpose To determine the clinical and epidemiological characteristics of abdominal wall endometriosis (AWE), as well as the rate and recurrence factors for the disease. Methods A retrospective study of 52 women with AWE was performed at Universidade Estadual de Campinas from 2004 to 2014. Of the 231 surgeries performed for the diagnosis of endometriosis, 52 women were found to have abdominal wall endometriosis (AWE). The frequencies, means and standard deviations of the clinical characteristics of these women were calculated, as well as the recurrence rate of AWE...
August 2017: Revista Brasileira de Ginecologia e Obstetrícia
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