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https://www.readbyqxmd.com/read/28874613/diaphragmatic-thickness-fraction-in-subjects-at-high-risk-for-copd-exacerbations
#1
Emel Eryüksel, Canan Cimşit, Melahat Bekir, Çagatay Cimsit, Sait Karakurt
BACKGROUND: Ultrasound-based diaphragmatic thickness fraction is a reflection of the size and function of the diaphragm. This study aimed to examine the value of this measurement in identifying patients with COPD who are at high risk for the development of symptoms and exacerbations. METHODS: This cross-sectional study included 53 subjects with COPD. Respiratory function test results, ultrasonography-based diaphragmatic thickness, symptom scores (modified Medical Research Council dyspnea scale); COPD Assessment Test results, and number of previous exacerbations and admissions were recorded...
September 5, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28874609/modified-medical-research-council-dyspnea-scale-in-gold-classification-better-reflects-physical-activities-of-daily-living
#2
Anelise B Munari, Aline A Gulart, Karoliny Dos Santos, Raysa S Venâncio, Manuela Karloh, Anamaria F Mayer
BACKGROUND: In multidimensional Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification, the choice of the symptom assessment instrument (modified Medical Research Council dyspnea scale [mMRC] or COPD assessment test [CAT]) can lead to a different distribution of patients in each quadrant. Considering that physical activities of daily living (PADL) is an important functional outcome in COPD, the objective of this study was to determine which symptom assessment instrument is more strongly associated with and differentiates better the PADL of patients with COPD...
September 5, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28871195/role-of-floral-organ-identity-genes-in-the-development-of-unisexual-flowers-of-quercus-suber-l
#3
Rómulo Sobral, M Manuela R Costa
Monoecious species provide an excellent system to study the specific determinants that underlie male and female flower development. Quercus suber is a monoecious species with unisexual flowers at inception. Despite the overall importance of this and other tree species with a similar reproductive habit, little is known regarding the mechanisms involved in the development of their male and female flowers. Here, we have characterised members of the ABCDE MADS-box gene family of Q. suber. The temporal expression of these genes was found to be sex-biased...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28858917/why-do-we-fail-to-deliver-evidence-based-practice-in-critical-care-medicine
#4
Curtis H Weiss
PURPOSE OF REVIEW: The use of evidence-based practices in clinical practice is frequently inadequate. Recent research has uncovered many barriers to the implementation of evidence-based practices in critical care medicine. Using a comprehensive conceptual framework, this review identifies and classifies the barriers to implementation of several major critical care evidence-based practices. RECENT FINDINGS: The many barriers that have been recently identified can be classified into domains of the consolidated framework for implementation research (CFIR)...
October 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/28840131/characterization-of-metabolically-healthy-obese-people-and-metabolically-unhealthy-normal-weight-people-in-a-general-population-cohort-of-the-abcd-study
#5
Silvio Buscemi, Pierfilippo Chiarello, Carola Buscemi, Davide Corleo, Maria Fatima Massenti, Anna Maria Barile, Giuseppe Rosafio, Vincenza Maniaci, Valentina Settipani, Loretta Cosentino, Carla Giordano
There is actually no consensus about the possibility that in some instances, obesity may be a benign metabolically healthy (MH) condition as opposed to a normal-weight but metabolically unhealthy (MUH) state. The aim of this study was to characterize MH condition and to investigate possible associations with metabolic and cardiovascular complications. One thousand nineteen people (range of age 18-90 years) of the cohort of the ABCD_2 study were investigated. Participants were classified as normal weight (BMI < 24...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28838240/low-temperature-molecular-layer-deposition-using-monofunctional-aromatic-precursors-and-ozone-based-ring-opening-reactions
#6
Laura Kaisa Kristiina Svärd, Matti Putkonen, Eija Kenttä, Timo Sajavaara, Fabian Krahl, Maarit Karppinen, Kevin Van de Kerckhove, Christophe Detavernier, Pekka Simell
Molecular Layer Deposition (MLD) is an increasingly used deposition technique for producing thin coatings consisting of purely organic or hybrid inorganic-organic materials. When organic materials are prepared, low deposition temperatures are often required to avoid decomposition, thus causing problems with low vapour pressure precursors. Monofunctional compounds have higher vapour pressures than traditional bi- or tri-functional MLD precursors, but do not offer the required functional groups for continuing the MLD growth in subsequent deposition cycles...
August 24, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28815602/efficacy-and-safety-of-amphotericin-b-formulations-a-network-meta-analysis-and-a-multicriteria-decision-analysis
#7
Fernanda S Tonin, Laiza M Steimbach, Helena H Borba, Andreia C Sanches, Astrid Wiens, Roberto Pontarolo, Fernando Fernandez-Llimos
OBJECTIVES: Despite its broad spectrum, conventional amphotericin B (AB) is associated with serious adverse events. Lipid-based formulations may offer safer options. We aimed to synthesize the evidence of efficacy and safety of AB formulations. METHODS: We performed a systematic review and network meta-analysis (NMA) to compare all available formulations: conventional AB; lipid complex or ABLC; colloidal dispersion or ABCD; liposomal or LAB; AB in Intralipid. Randomized controlled trials were searched in four databases...
August 17, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28806988/subjective-safety-and-self-confidence-in-prehospital-trauma-care-and-learning-progress-after-trauma-courses-part-of-the-prospective-longitudinal-mixed-methods-epptc-trial
#8
David Häske, Stefan K Beckers, Marzellus Hofmann, Rolf Lefering, Paul A Grützner, Ulrich Stöckle, Vassilios Papathanassiou, Matthias Münzberg
BACKGROUND: Prehospital trauma care is stressful and requires multi-professional teamwork. A decrease in the number of accident victims ultimately affects the routine and skills and underlines the importance of effective training. Standardized courses, like PHTLS, are established for health care professionals to improve the prehospital care of trauma patients. The aim of the study was to investigate the subjective safety in prehospital trauma care and learning progress by paramedics in a longitudinal analysis...
August 14, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28803221/reflective-student-narratives-honing-professionalism-and-empathy
#9
Upreet Dhaliwal, Satendra Singh, Navjeevan Singh
The affective domain is not explicitly targeted during medical studies and poor skills in this domain may lead to conflict when dealing with patients. Reflective narratives are said to promote humanitarianism and professional development. We aimed to examine reflective narratives written by medical students in our institution for content relating to ethical and professional Attitude and Behaviour, Communication, respect for Diversity and Disability, and Empathy (the ABCDE paradigm). We were also interested in understanding how far the students enjoyed learning through the writing of narratives and in determining their perceived learning from the exercise...
July 18, 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28795271/efficacy-of-sleeve-gastrectomy-with-duodenal-jejunal-bypass-for-the-treatment-of-obese-severe-diabetes-patients-in-japan-a-retrospective-multicenter-study
#10
Takeshi Naitoh, Kazunori Kasama, Yosuke Seki, Masayuki Ohta, Takashi Oshiro, Akira Sasaki, Yasuhiro Miyazaki, Tsuyoshi Yamaguchi, Hideki Hayashi, Hirofumi Imoto, Naoki Tanaka, Michiaki Unno
BACKGROUND: The incidence of obesity with type 2 diabetes (T2DM) is increasing in Japan. The main bariatric surgery procedures in Japan are laparoscopic sleeve gastrectomy (LSG) and LSG with duodenal-jejunal bypass (LSG/DJB) because of the high incidence of gastric cancer and difficulty exploring a remnant stomach after gastric bypass. However, few studies have compared the antidiabetic effect of LSG/DJB with LSG alone. PURPOSE: The purpose of this study is to compare the antidiabetic effect of LSG/DJB with that of LSG alone in Japanese obese diabetic patients...
August 9, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28759333/do-pattern-focused-visuals-improve-skin-self-examination-performance-explicating-the-visual-skill-acquisition-model
#11
RANDOMIZED CONTROLLED TRIAL
Kevin K John, Jakob D Jensen, Andy J King, Chelsea L Ratcliff, Douglas Grossman
Skin self-examination (SSE) consists of routinely checking the body for atypical moles that might be cancerous. Identifying atypical moles is a visual task; thus, SSE training materials utilize pattern-focused visuals to cultivate this skill. Despite widespread use, researchers have yet to explicate how pattern-focused visuals cultivate visual skill. Using eye tracking to capture the visual scanpaths of a sample of laypersons (N = 92), the current study employed a 2 (pattern: ABCDE vs. ugly duckling sign [UDS]) × 2 (presentation: photorealistic images vs...
September 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28747297/photoaging-mobile-apps-as-a-novel-opportunity-for-melanoma-prevention-pilot-study
#12
Titus Josef Brinker, Dirk Schadendorf, Joachim Klode, Ioana Cosgarea, Alexander Rösch, Philipp Jansen, Ingo Stoffels, Benjamin Izar
BACKGROUND: Around 90% of melanomas are caused by ultraviolet (UV) exposure and are therefore eminently preventable. Unhealthy tanning behavior is mostly initiated in early adolescence, often with the belief that it increases attractiveness; the problems related to skin atrophy and malignant melanoma are too far in the future to fathom. Photoaging desktop programs, in which an image is altered to predict future appearance, have been successful in positively influencing behavior in adiposity or tobacco prevention settings...
July 26, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28737695/predictive-structure-and-topology-of-peroxisomal-atp-binding-cassette-abc-transporters
#13
Pierre Andreoletti, Quentin Raas, Catherine Gondcaille, Mustapha Cherkaoui-Malki, Doriane Trompier, Stéphane Savary
The peroxisomal ATP-binding Cassette (ABC) transporters, which are called ABCD1, ABCD2 and ABCD3, are transmembrane proteins involved in the transport of various lipids that allow their degradation inside the organelle. Defective ABCD1 leads to the accumulation of very long-chain fatty acids and is associated with a complex and severe neurodegenerative disorder called X-linked adrenoleukodystrophy (X-ALD). Although the nucleotide-binding domain is highly conserved and characterized within the ABC transporters family, solid data are missing for the transmembrane domain (TMD) of ABCD proteins...
July 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28716389/biomedical-ethics-and-clinical-oversight-in-multisite-observational-neuroimaging-studies-with-children-and-adolescents-the-abcd-experience
#14
REVIEW
Duncan B Clark, Celia B Fisher, Susan Bookheimer, Sandra A Brown, John H Evans, Christian Hopfer, James Hudziak, Ivan Montoya, Margaret Murray, Adolf Pfefferbaum, Deborah Yurgelun-Todd
Observational neuroimaging studies with children and adolescents may identify neurological anomalies and other clinically relevant findings. Planning for the management of this information involves ethical considerations that may influence informed consent, confidentiality, and communication with participants about assessment results. Biomedical ethics principles include respect for autonomy, beneficence, non-maleficence, and justice. Each project presents unique challenges. The Adolescent Brain and Cognitive Development study (ABCD) collaborators have systematically developed recommendations with written guidelines for identifying and responding to potential risks that adhere to biomedical ethics principles...
June 28, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28714256/a1s_2811-a-chea-y-like-hybrid-two-component-regulator-from-acinetobacter%C3%A2-baumannii-atcc17978-is-involved-in-surface-motility-and-biofilm-formation-in-this-bacterium
#15
Rong Chen, Ruichen Lv, Lisheng Xiao, Min Wang, Zongmin Du, Yafang Tan, Yujun Cui, Yanfeng Yan, Yanping Luo, Ruifu Yang, Yajun Song
Two-component systems in Acinetobacter baumannii are associated with its virulence, drug resistance, motility, biofilm formation, and other characteristics. In this study, we used RecAb , a genetic engineering method, to investigate the function of A1S_2811 in A. baumannii strain ATCC17978. A1S_2811, a hypothetical hybrid sensor histidine kinase/response regulator, has four histidine-containing phosphotransfer domains, a CheA-like regulatory domain, and a CheY-like receiver domain at its C terminus. Compared with the ATCC17978 strain, both surface motility and biofilm formation at the gas-liquid interface decreased significantly in the A1S_2811 knock-out strain...
July 17, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28669625/clinical-risk-factors-predicting-genital-fungal-infections-with-sodium-glucose-cotransporter-2-inhibitor-treatment-the-abcd-nationwide-dapagliflozin-audit
#16
Ken Yan Thong, Mahender Yadagiri, Dennis Joseph Barnes, David Stuart Morris, Tahseen Ahmad Chowdhury, Ling Ling Chuah, Anthony Michael Robinson, Stephen Charles Bain, Karen Ann Adamson, Robert Elford John Ryder
INTRODUCTION: Treatment of type 2 diabetes with sodium-glucose cotransporter 2 (SGLT2) inhibitors may result in genital fungal infections. We investigated possible risk factors for developing such infections among patients treated with the SGLT2 inhibitor dapagliflozin. METHODS: The Association of British Clinical Diabetologists (ABCD) collected data on patients treated with dapagliflozin in routine clinical practice from 59 diabetes centres. We assessed possible associations of patient's age, diabetes duration, body mass index, glycated haemoglobin, renal function, patient sex, ethnicity and prior genital fungal infection, urinary tract infection, urinary incontinence or nocturia, with the occurrence of ≥1 genital fungal infection within 26 weeks of treatment...
June 29, 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28668925/perceptions-of-workload-burden-and-adherence-to-abcde-bundle-among-intensive-care-providers
#17
Leanne M Boehm, Mary S Dietrich, Eduard E Vasilevskis, Nancy Wells, Pratik Pandharipande, E Wesley Ely, Lorraine C Mion
BACKGROUND: Use of the interprofessional Awakening and Breathing Coordination, Delirium Monitoring and Management, and Early Mobility (ABCDE) bundle is recommended practice in intensive care, but its adoption remains limited. OBJECTIVE: To examine the relationship between intensive care unit provider attitudes regarding the ABCDE bundle and ABCDE bundle adherence. METHODS: A 1-time survey of 268 care providers in 10 intensive care units across the country who had worked at least 4 shifts per month to examine their attitudes toward workload burden, difficulty carrying out the bundle, perceived safety, confidence, and perceived strength of evidence...
July 2017: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
https://www.readbyqxmd.com/read/28648173/abcd
#18
REVIEW
Ab
No abstract text is available yet for this article.
July 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28641158/determinants-of-cortisol-during-pregnancy-the-abcd-cohort
#19
Laura S Bleker, Tessa J Roseboom, Tanja G Vrijkotte, Rebecca M Reynolds, Susanne R de Rooij
BACKGROUND: Psychosocial stress during pregnancy has been proposed as a major contributor of glucocorticoid-mediated programming of the fetal hypothalamic-pituitary adrenal (HPA) axis, with later adverse health consequences. However, evidence linking maternal stress to maternal cortisol values during pregnancy is inconclusive. A possible explanation for this is that other maternal factors overshadow any potential effects of stress on cortisol levels. We studied a large cohort of pregnant women with extensive data on pregnancy characteristics to determine the respective contributions of biological, environmental and psychosocial stress factors to cortisol levels in pregnancy...
May 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28626106/-seedi-basic-strategies-for-the-primary-and-secondary-prevention-of-atherosclerotic-cardiovascular-disease
#20
Chunsong Hu
ABCDE strategy, mainly based on drugs or medications and the lifestyle modification (named as "main medical strategy"), is popular in the guideline for primary and secondary prevention of atherosclerotic cardiovascular disease (ASCVD) in China and foreign countries. Here, the author recommends a non-invasive and non-pharmacologic "Zhongzi" rule, which includes 4 healthy elements: Sleep, emotion, exercise, and diet (SEED), and also called SEED intervention (SEEDi) strategy. It is the basic strategy for primary and secondary prevention of non-infectious diseases, especially for ASCVD...
May 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
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