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Klebsiella pneumoniae

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https://www.readbyqxmd.com/read/29784578/quantitative-study-about-the-role-of-environmental-conditions-in-the-survival-capability-of-multidrug-resistant-bacteria
#1
Adrienn Hanczvikkel, Ákos Tóth
BACKGROUND: Healthcare-associated infections (HAIs) caused by multidrug-resistant bacteria (MDRB) are of global concern and hospital textiles can contribute to their transmission. MDRB are able to survive on textiles for more than enough time to spread in the environment. Some studies summarized the effect of environmental factors on the duration of bacterial survival, but it remained an open question how these factors influence the quantity of surviving bacteria in a period of a few days, which is relevant from the perspective of HAIs...
May 18, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29782237/effect-of-porins-and-bla-kpc-expression-on-activity-of-imipenem-with-relebactam-in-klebsiella-pneumoniae-can-antibiotic-combinations-overcome-resistance
#2
Gregory Balabanian, Michael Rose, Nyla Manning, David Landman, John Quale
Imipenem with relebactam is a novel β-lactam-β-lactamase inhibitor that has activity against most KPC-producing Enterobacteriaceae. Using 10 isolates of KPC-possessing Klebsiella pneumoniae, we assessed the relationship between imipenem-relebactam minimum inhibitory concentrations (MICs) and mechanisms known to contribute to antimicrobial resistance. The effect of adding a second agent was assessed by time-kill experiments. Mutations affecting the genes encoding porins ompK35 and ompK36 and identification of β-lactamases were assessed by PCR...
May 21, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29782216/carbapenemase-producing-carbapenem-resistant-enterobacteriaceae-from-bangkok-thailand-and-their-detection-by-the-carba-np-and-modified-carbapenem-inactivation-method-tests
#3
Warawut Laolerd, Yukihiro Akeda, Likit Preeyanon, Panan Ratthawongjirakul, Pitak Santanirand
AIM: The purpose of the study was to determine the epidemiology of carbapenemase genes among carbapenem-resistant Enterobacteriaceae and evaluate the Carba NP and modified carbapenem inactivation method (mCIM) tests in their detection. MATERIALS AND METHODS: A total of 287 nonduplicated Enterobacteriaceae isolates, which were at least resistant to one of the carbapenems, were identified and detected for carbapenemase genes by multiplex PCR covering blaKPC , blaNDM , blaVIM , blaIMP , and blaOXA-48-like ...
May 21, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29782210/colonization-with-enterobacteriaceae-producing-esbls-ampcs-and-oxa-48-in-wild-avian-species-spain-2015-2016
#4
Jesús Oteo, Aida Mencía, Verónica Bautista, Natalia Pastor, Noelia Lara, Fernando González-González, Francisco Javier García-Peña, José Campos
Antibiotic resistance is a global threat of complex and changeable epidemiology. The role of wild birds in the dissemination of antibacterial resistance might be underestimated. We studied the cloacal colonization by cefotaxime-resistant Enterobacteriaceae in 668 wild birds in Spain. Eighty-eight wild birds (13.2%) of 28 species carried cefotaxime-resistant isolates; 58 of them (8.7%) carried extended-spectrum β-lactamases (ESBLs) and 15 (2.5%) plasmid-mediated AmpCs of the blaCIT family. The 58 ESBLs belonged to the CTX-M-1 group (63...
May 21, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29781800/linkage-of-the-nit1c-gene-cluster-to-bacterial-cyanide-assimilation-as-a-nitrogen-source
#5
Lauren B Jones, Pallab Ghosh, Jung-Hyun Lee, Chia-Ni Chou, Daniel A Kunz
A genetic linkage between a conserved gene cluster (Nit1C) and the ability of bacteria to utilize cyanide as the sole nitrogen source was demonstrated for nine different bacterial species. These included three strains whose cyanide nutritional ability has formerly been documented (Pseudomonas fluorescens Pf11764, Pseudomonas putida BCN3 and Klebsiella pneumoniae BCN33), and six not previously known to have this ability [Burkholderia (Paraburkholderia) xenovorans LB400, Paraburkholderia phymatum STM815, Paraburkholderia phytofirmans PsJN, Cupriavidus (Ralstonia) eutropha H16, Gluconoacetobacter diazotrophicus PA1 5 and Methylobacterium extorquens AM1]...
May 21, 2018: Microbiology
https://www.readbyqxmd.com/read/29781594/-monoclonal-spread-of-multi-drug-resistant-ctx-m-15-producing-klebsiella-pneumoniae-impact-of-measures-to-control-the-outbreak
#6
M A Asencio Egea, M Huertas Vaquero, C Muñoz-Cuevas, J Gaitán Pitera, O Herráez Carrera, P Alcázar Carmona, H D Patiño Ortega, M Franco Huerta, C Román Ortiz, M C Conde García, R Carranza González, J R Barberá, V Bautista Sánchez
OBJECTIVE: To describe an outbreak of multi-drug resistant extended-spectrum β-lactamases-producing Klebsiella pneumoniae (MDR-ESBL-KPN) and the impact of measures for its control. METHODS: We reviewed the patients´ clinical records with MDR-ESBL-KPN isolation during 2013-2016 with resistance to fluoroquinolones, aminoglycosides, fosfomycin, and nitrofurantoin; susceptible to imipenem, meropenem, colistin, and tigecycline and variable to ertapenem and cotrimoxazole (Vitek-2)...
May 18, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29780759/para-substituted-functionalised-ferrocene-esters-with-novel-antibacterial-properties
#7
Kevin Muñoz Forti, Faviola Bernard, Gustavo Santiago-Collazo, Waldemar Garcia, Jose L Vera, Enrique Meléndez, Edu B Suarez-Martinez
Introduction: Bacterial antibiotic resistance is on rise despite advances in the development of new antibiotics. In an attempt to circumvent resistance, scientists are shifting focus from modifying existent antibiotics to identifying new antibiotic compounds. Aim: To assess the potential antibiotic effects of functionalised ferrocenecarboxylates para-substituted on the phenoxy pendant group to form: 4-fluorophenyl, 4-chlorophenyl, 4-bromophenyl, 4-iodophenyl and 4-(H-pyrrol-1-yl)phenyl...
February 2018: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29775786/is-mic-increase-of-meropenem-against-klebsiella-pneumoniae-carbapenemase-kpc-producing-klebsiella-pneumoniae-correlated-with-the-increase-of-resistance-rates-against-some-other-antibiotics-with-gram-negative-activity
#8
Piergiorgio Cojutti, Assunta Sartor, Matteo Bassetti, Claudio Scarparo, Federico Pea
OBJECTIVE: To assess MIC distribution for meropenem and the other antibiotics with Gram-negative activity against KPC-Kp clinical isolates collected at our hospital in 2013-2016. METHODS: Susceptibility of KPC-Kp strains was tested by broth microdilution method, using customized 96-well plates, and was interpreted according to the EUCAST recommendations. RESULTS: Among 169 consecutive KPC-Kp clinical isolates 26.6% were susceptible to meropenem...
May 15, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29774893/prevalence-and-antimicrobial-sensitivity-pattern-of-urinary-tract-infection-among-children-with-cerebral-palsy-moshi-tanzania
#9
Amon Ryakitimbo, Rune Philemon, Festo Mazuguni, Levina Msuya
Background: Urinary tract infection (UTI) in children with cerebral palsy (CP) is a challenging yet common clinical condition. Children with CP bare the greatest risk of contracting UTI because of their difficulties in neuromotor control which lead to delay of bladder control, causing incomplete bladder emptying and urine retention. Method: This was an analytical cross-sectional study that was conducted from September 2016 to March 2017 at Comprehensive Community Based Rehabilitation in Tanzania - Moshi and Kilimanjaro Christian Medical Centre Neurological Pediatrics Outpatient Clinic...
2018: Pediatric Health, Medicine and Therapeutics
https://www.readbyqxmd.com/read/29774878/-etiology-and-risk-factors-for-meningitis-and-or-bacteremia-after-craniotomy-for-patients-with-glioma
#10
Yaning Wang, Yu Wang, Wenbin Ma
To evaluate the incidence and microbiological profile of meningitis and/or bacteremia after craniotomy in patients with glioma and analyze the risk factors relevant to postoperative meningitis.
 Methods: All demographic data, etiological data and clinical data for hospitalized patients who underwent craniotomy in Dept. of Neurosurgery of Peking Union Medical College Hospital between Jan. 2013 to Dec. 2017 were recorded.
 Results: The incidence of post-craniotomy meningitiswas 7.73%, bacteremia was 2.21% and meningitis combined with bacteremia was 1...
April 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29774858/genomic-epidemiology-of-global-carbapenemase-producing-enterobacter-spp-2008-2014
#11
Gisele Peirano, Yasufumi Matsumura, Mark D Adams, Patricia Bradford, Mary Motyl, Liang Chen, Barry N Kreiswirth, Johann D D Pitout
We performed whole-genome sequencing on 170 clinical carbapenemase-producing Enterobacter spp. isolates collected globally during 2008-2014. The most common carbapenemase was VIM, followed by New Delhi metallo-β-lactamase (NDM), Klebsiella pneumoniae carbapenemase, oxacillin 48, and IMP. The isolates were of predominantly 2 species (E. xiangfangensis and E. hormaechei subsp. steigerwaltii) and 4 global clones (sequence type [ST] 114, ST93, ST90, and ST78) with different clades within ST114 and ST90. Particular genetic structures surrounding carbapenemase genes were circulating locally in various institutions within the same or between different STs in Greece, Guatemala, Italy, Spain, Serbia, and Vietnam...
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29774213/a-rapid-growth-independent-antibiotic-resistance-detection-test-by-sybr-green-propidium-iodide-viability-assay
#12
Jie Feng, Rebecca Yee, Shuo Zhang, Lili Tian, Wanliang Shi, Wen-Hong Zhang, Ying Zhang
Antibiotic-resistant bacteria have caused huge concerns and demand innovative approaches for their prompt detection. Current antimicrobial susceptibility tests (AST) rely on the growth of the organisms which takes 1-2 days for fast-growing organisms and several weeks for slow growing organisms. Here, we show for the first time the utility of the SYBR Green I/propidium iodide (PI) viability assay for rapidly identifying antibiotic resistance in less than 30 min for major, antibiotic-resistant, fast-growing bacteria, such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae , and Acinetobacter baumannii for bactericidal and bacteriostatic agents and in 16 h for extremely rapid detection of drug resistance for isoniazid and pyrazinamide in slow-growing Mycobacterium tuberculosis ...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29772647/the-antimicrobial-activity-of-annona-emarginata-schltdl-h-rainer-and-most-active-isolated-compounds-against-clinically-important-bacteria
#13
Juan G Dolab, Beatriz Lima, Ewelina Spaczynska, Jiri Kos, Natividad H Cano, Gabriela Feresin, Alejandro Tapia, Francisco Garibotto, Elisa Petenatti, Monica Olivella, Robert Musiol, Josef Jampilek, Ricardo D Enriz
Annona emarginata (Schltdl.) H. Rainer, commonly known as "arachichú", "araticú", "aratigú", and "yerba mora", is a plant that grows in Argentina. Infusions and decoctions are used in folk medicine as a gargle against throat pain and for calming toothache; another way to use the plant for these purposes is chewing its leaves. Extracts from bark, flowers, leaves, and fruits from A. emarginata were subjected to antibacterial assays against a panel of Gram (+) and Gram (-) pathogenic bacteria according to Clinical and Laboratory Standards Institute protocols...
May 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29769274/a-comparative-evaluation-of-four-phenotypic-methods-for-detection-of-class-a-and-b-carbapenemase-producing-enterobacteriaceae-in-china
#14
Menglan Zhou, Danchen Wang, Timothy Kudinha, Qiwen Yang, Shuying Yu, Ying-Chun Xu
Objectives: To evaluate the performance of four phenotypic methods in the detection of carbapenemase-producing Enterobacteriaceae (CPE) in China. Methods: We evaluated the performance of four carbapenemase detection methods, the modified Hodge test (MHT), Carba NP test, meropenem hydrolysis assay (MHA) with 1 and 2-hour incubation, and modified carbapenem inactivation method (mCIM) with meropenem, imipenem, and ertapenem, on 342 carbapenem-resistant Enterobacteriaceae (CRE) in China. Polymerase chain reaction was used as the gold standard...
May 16, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29768382/transbronchial-drainage-using-endobronchial-ultrasonography-with-guide-sheath-for-lung-abscess-a-case-report
#15
Daizo Yaguchi, Motoshi Ichikawa, Noriko Inoue, Daisuke Kobayashi, Masato Shizu, Naoyuki Imai
RATIONALE: Lung abscess was previously treated surgically, but is now mainly treated with antibiotics and ideally with direct drainage, although postural drainage canalso be used. PATIENT CONCERNS: A chest abnormal shadow was detected in an 82-year-old man and he was referred to our department in November 2017. On chest computed tomography (CT), a low-density mass shadow was present in the left S8 segment. Lung abscess and lung cancer were considered as differential diagnoses, and treatment with sulbactam sodium/ampicillin sodium (SBT/ABPC) was first initiated for lung abscess...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29768225/optimisation-of-preparation-conditions-for-ti-nanowires-and-suitability-as-an-antibacterial-material
#16
Thivyah Munisparan, Evyan Chia Yan Yang, Ragul Paramasivam, Nuraina Anisa Dahlan, Janarthanan Pushpamalar
Ultrafine titanium dioxide (TiO2 ) nanowires were synthesised using a hydrothermal method with different volumes of ethylene glycol (EG) and annealing temperatures. It shows that sodium titanate nanowires synthesised using 5 and 10 ml EG, which annealed at 400°C produced TiO2 nanowires that correspond to a photochemically active phase, which is anatase. The influences of annealing temperatures (400-600°C) on the morphological arrangement of TiO2 nanowires were evident in the field emission scanning electron microscopy...
June 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29768099/the-mcr-1-gene-has-no-effect-on-colistin-resistance-when-it-coexists-with-inactivated-mgrb-gene-in-klebsiella-pneumoniae
#17
Huichuan Zhang, Dongdong Zhao, Qiucheng Shi, Jingjing Quan, Xi Li, Yunsong Yu
The inactivated mgrB gene and the mcr-1 gene are important mechanisms of colistin resistance in Klebsiella pneumoniae and they are threats to the clinical use of colistin. In this study, mcr-1 gene was cloned into K. pneumoniae strains (XH209 and KP10) and their derived strains (XH209 M and KP10 M), which showed high-level resistance to colistin. The acquisition of the mcr-1 gene led to colistin resistance in XH209 and KP10, but the addition of mcr-1 gene did not cause change of colistin minimum inhibitory concentrations in the XH209 M and KP10 M...
May 16, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29767453/optimizing-antimicrobial-peptide-dendrimers-in-chemical-space
#18
Thissa Siriwardena, Alice Capecchi, Bee-Ha Gan, Xian Jin, Runze He, Dengwen Wei, Lan Ma, Thilo Köhler, Christian van Delden, Sacha Javor, Jean-Louis Reymond
Here we used nearest neighbor searches in chemical space to improve the activity of antimicrobial peptide dendrimer (AMPD) G3KL and identified dendrimer T7 with an expanded activity range against Gram-negative pathogenic bacteria including Klebsiellae pneumoniae, increased serum stability and promising activity in an in vivo infection model against a multidrug resistant strain of Acinetobacter baumannii. Imaging, spectroscopic studies and a structural model from molecular dynamics simulations suggest that T7 acts by membrane disruption...
May 16, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29765868/retrobulbar-steatitis-and-meningitis-empyema-secondary-to-right-otitis-media-right-otitis-interna-and-an-inflammatory-polyp-in-a-cat
#19
Elena Fenollosa-Romero, Olivier Taeymans, Pieter Nelissen, Giunio B Cherubini, Claudia Busse
The purpose was to describe a case of retrobulbar steatitis and meningitis in a cat caused by otitis media, otitis interna and an inflammatory polyp in the middle ear. Investigations included ophthalmic and neurological examinations, haematology and biochemistry, magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis and aerobic, anaerobic bacterial and fungal culture of material from the middle ear. A 6-year-old female neutered domestic-short-haired cat presented with right-sided exophthalmos and resistance to retropulsion...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29765367/detection-of-bacteriophage-particles-containing-antibiotic-resistance-genes-in-the-sputum-of-cystic-fibrosis-patients
#20
Maryury Brown-Jaque, Lirain Rodriguez Oyarzun, Thais Cornejo-Sánchez, Maria T Martín-Gómez, Silvia Gartner, Javier de Gracia, Sandra Rovira, Antonio Alvarez, Joan Jofre, Juan J González-López, Maite Muniesa
Cystic fibrosis (CF) is a chronic disease in which the bacterial colonization of the lung is linked to an excessive inflammatory response that leads to respiratory failure. The microbiology of CF is complex. Staphylococcus aureus is the first bacterium to colonize the lungs in 30% of pediatric CF patients, and 80% of adult patients develop a chronic Pseudomonas aeruginosa infection, but other microorganisms can also be found. The use of antibiotics is essential to treat the disease, but antibiotic performance is compromised by resistance mechanisms...
2018: Frontiers in Microbiology
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