keyword
https://read.qxmd.com/read/37230551/thinking-clearly-the-history-of-brain-dysfunction-in-critical-illness
#21
REVIEW
Kimberly F Rengel, Matthew F Mart, Jo Ellen Wilson, E Wesley Ely
Brain dysfunction during critical illness (ie, delirium and coma) is extremely common, and its lasting effect has only become increasingly understood in the last two decades. Brain dysfunction in the intensive care unit (ICU) is an independent predictor of both increased mortality and long-term impairments in cognition among survivors. As critical care medicine has grown, important insights regarding brain dysfunction in the ICU have shaped our practice including the importance of light sedation and the avoidance of deliriogenic drugs such as benzodiazepines...
July 2023: Critical Care Clinics
https://read.qxmd.com/read/37125798/caring-for-critically-ill-children-with-the-icu-liberation-bundle-abcdef-results-of-the-pediatric-collaborative
#22
MULTICENTER STUDY
John C Lin, Avantika Srivastava, Sara Malone, Susan Jennison, Megan Simino, Chani Traube, Kimberly LaRose, Yu Kawai, Lori Neu, Sapna Kudchadkar, Beth Wieczorek, Krista Hajnik, Christina M Kordik, Vishakha K Kumar, Sara Aghamohammadi, Grace M Arteaga, Heidi A B Smith, Thomas Spentzas, Andrea Orman, Becky McGee Landman, Hector Valdivia, Heather Browne, Timothy Fang, Jerry J Zimmerman
OBJECTIVES: Assess clinical outcomes following PICU Liberation ABCDEF Bundle utilization. DESIGN: Prospective, multicenter, cohort study. SETTING: Eight academic PICUs. PATIENTS: Children greater than 2 months with expected PICU stay greater than 2 days and need for mechanical ventilation (MV). INTERVENTIONS: ABCDEF Bundle implementation. MEASUREMENT AND MAIN RESULTS: Over an 11-month period (3-mo baseline, 8-mo implementation), Bundle utilization was measured for 622 patients totaling 5,017 PICU days...
August 1, 2023: Pediatric Critical Care Medicine
https://read.qxmd.com/read/37072096/the-abcdef-method-a-step-by-step-guide-for-pain-management-resource-development
#23
EDITORIAL
Emily H Garmon
No abstract text is available yet for this article.
April 16, 2023: American Journal of Medicine
https://read.qxmd.com/read/37034022/enhancing-the-awakening-to-family-engagement-bundle-with-music-therapy
#24
REVIEW
Ariel M Modrykamien
Survivors of prolonged intensive care unit (ICU) admissions may present undesirable long-term outcomes. In particular, physical impairment and cognitive dysfunction have both been described in patients surviving episodes requiring mechanical ventilation and sedation. One of the strategies to prevent the aforementioned outcomes involves the implementation of a bundle composed by: (1) Spontaneous awakening trial; (2) Spontaneous breathing trial; (3) Choosing proper sedation strategies; (4) Delirium detection and management; (5) Early ICU mobility; and (6) Family engagement (ABCDEF bundle)...
March 9, 2023: World Journal of Critical Care Medicine
https://read.qxmd.com/read/36923334/abcdef%C3%A2-sudep-action-potential-barrage-in-superior-colliculus-causes-spreading-depolarization-leading-to-epilepsy-fatality
#25
COMMENT
Gordon F Buchanan
No abstract text is available yet for this article.
2023: Epilepsy Currents
https://read.qxmd.com/read/36892899/serial-order-depends-on-item-dependent-and-item-independent-contexts
#26
JOURNAL ARTICLE
Gordon D Logan, Gregory E Cox
We address four issues in response to Osth and Hurlstone's (2022) commentary on the context retrieval and updating (CRU) theory of serial order (Logan, 2021). First, we clarify the relations between CRU, chains, and associations. We show that CRU is not equivalent to a chaining theory and uses similarity rather than association to retrieve contexts. Second, we fix an error Logan (2021) made in accounting for the tendency to recall ACB instead of ACD in recalling ABCDEF (fill-in vs. in-fill errors, respectively)...
March 9, 2023: Psychological Review
https://read.qxmd.com/read/36890874/an-exploration-of-critical-care-professionals-strategies-to-enhance-daily-implementation-of-the-assess-prevent-and-manage-pain-both-spontaneous-awakening-and-breathing-trials-choice-of-analgesia-and-sedation-delirium-assess-prevent-and-manage-early-mobility
#27
JOURNAL ARTICLE
Lorraine C Mion, Alai Tan, Audrey Brockman, Judith A Tate, Eduard E Vasilevskis, Brenda T Pun, Scott R Rosas, Michele C Balas
UNLABELLED: The goals of this exploratory study were to engage professionals from the Society for Critical Care Medicine ICU Liberation Collaborative ICUs to: 1) conceptualize strategies to enhance daily implementation of the Assess, prevent, and manage pain; Both spontaneous awakening and breathing trials; Choice of analgesia and sedation; Delirium assess, prevent, and manage; Early mobility and exercise; and Family engagement and empowerment (ABCDEF) bundle from different perspectives and 2) identify strategies to prioritize for implementation...
March 2023: Critical care explorations
https://read.qxmd.com/read/36854912/measuring-performance-on-the-abcdef-bundle-during-interprofessional-rounds-via-a-nurse-based-assessment-tool
#28
JOURNAL ARTICLE
Andrew J King, Kelly M Potter, Jennifer B Seaman, Elizabeth A Chiyka, Bethany A Hileman, Gregory F Cooper, Danielle L Mowery, Derek C Angus, Jeremy M Kahn
BACKGROUND: Nurse-led rounding checklists are a common strategy for facilitating evidence-based practice in the intensive care unit (ICU). To streamline checklist workflow, some ICUs have the nurse or another individual listen to the conversation and customize the checklist for each patient. Such customizations assume that individuals can reliably assess whether checklist items have been addressed. OBJECTIVE: To evaluate whether 1 critical care nurse can reliably assess checklist items on rounds...
March 1, 2023: American Journal of Critical Care
https://read.qxmd.com/read/36854908/abcdef-bundle
#29
JOURNAL ARTICLE
Sara Grieshop
No abstract text is available yet for this article.
March 1, 2023: American Journal of Critical Care
https://read.qxmd.com/read/36846543/-robotic-assisted-mobilization-for-an-effective-mobilization-in-a-covid-19-patient-with-ecmo-treatment
#30
JOURNAL ARTICLE
Frank Dieterich, Jan Perras, Wolfram Popp, Marlena Ahrens, Steffen Wirth
An effective (early) mobilization in COVID-19 intensive care patients with ECMO treatment is very important. Sedation, extracorporeal procedures with the danger of circuit malfunction, large lumen ECMO cannulas with a risk of dislocation and a very severe neuromuscular weakness are factors that could deem mobilization beyond stage 1 of the ICU mobility score (IMS) in some cases difficult or impossible; however, early mobilization is a key point of the ABCDEF bundle to counteract pulmonary complications, neuromuscular dysfunction and enable recovery...
2023: Procare: Das Forbildungsmagazin Fur Pflegeberufe
https://read.qxmd.com/read/36835809/sepsis-associated-delirium-a-narrative-review
#31
REVIEW
Rina Tokuda, Kensuke Nakamura, Yudai Takatani, Chie Tanaka, Yutaka Kondo, Hiroyuki Ohbe, Hiroshi Kamijo, Kosuke Otake, Atsuo Nakamura, Hiroyasu Ishikura, Yu Kawazoe, J-Stad Japan Sepsis Treatment And Diagnosis Study Group
Delirium is characterized by an acutely altered mental status accompanied by reductions in cognitive function and attention. Delirium in septic patients, termed sepsis-associated delirium (SAD), differs in several specific aspects from the other types of delirium that are typically encountered in intensive care units. Since sepsis and delirium are both closely associated with increased morbidity and mortality, it is important to not only prevent but also promptly diagnose and treat SAD. We herein reviewed the etiology, pathogenesis, risk factors, prevention, diagnosis, treatment, and prognosis of SAD, including coronavirus disease 2019 (COVID-19)-related delirium...
February 6, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/36577261/the-effect-of-the-abcde-abcdef-bundle-on-delirium-functional-outcomes-and-quality-of-life-in-critically-ill-patients-a-systematic-review-and-meta-analysis
#32
REVIEW
Kellie Sosnowski, Frances Lin, Wendy Chaboyer, Kristen Ranse, Aaron Heffernan, Marion Mitchell
BACKGROUND: The effect of the ABCDEF bundle (Assess, prevent, and manage pain; Both spontaneous awakening and spontaneous breathing trials; Choice of analgesia and sedation; Delirium: assess, prevent, and manage; Early mobility and exercise; and Family engagement and empowerment) on patient outcomes such as delirium is potentially optimised when the bundle is implemented in its entirety. OBJECTIVE: To systematically synthesise the evidence on the effectiveness of the ABCDEF bundle delivered in its entirety on delirium, function, and quality of life in adult intensive care unit patients...
February 2023: International Journal of Nursing Studies
https://read.qxmd.com/read/36538394/total-synthesis-of-puberuline-c
#33
JOURNAL ARTICLE
Tsukasa Shimakawa, Shu Nakamura, Hibiki Asai, Koichi Hagiwara, Masayuki Inoue
Puberuline C ( 1 ) is an architecturally complex C19 -diterpenoid alkaloid with a unique ring fusion pattern. The 6/7/5/6/6/6-membered rings (ABCDEF-rings) contain one tertiary amine and six oxygen functionalities, and possess 12 contiguously aligned stereocenters, three of which are quaternary. These structural features of 1 make its chemical construction exceptionally challenging. Here, we disclose the first total synthesis of 1 . The synthesis was accomplished from 2-cyclohexenone ( 9 ) by integrating radical cascade and Mukaiyama aldol reactions as the key transformations...
December 20, 2022: Journal of the American Chemical Society
https://read.qxmd.com/read/36477847/practice-integration-as-an-effective-educational-strategy
#34
JOURNAL ARTICLE
Kathrine Anne Winnie, Kimberly Sanchez, Elizabeth Winfrey, Amber Furlow, Lani Thong, Christopher Mitchell, Jennifer Cannon
Bundles are composed of individually established practices supported by research that, when combined, structure patient care. Implementing bundles improves patient outcomes. The ABCDEF initiative is an example of a bundled approach that improves outcomes of critically ill patients that are related to the likelihood of hospital death within 7 days, delirium and coma days, physical restraint use, intensive care unit readmission, and discharge disposition, with outcomes being proportional to the number of appropriate components performed...
December 15, 2022: AACN Advanced Critical Care
https://read.qxmd.com/read/36461794/hla-dpb1-molecular-mismatches-are-risk-factors-for-acute-rejection-and-low-5-year-graft-function-in-first-kidney-transplants
#35
JOURNAL ARTICLE
Renato de Marco, Lúcio R Requião-Moura, Tamiris R F Raimundo, Tuíla B Mourão, Gisele F Rampim, José O Medina-Pestana, Hélio Tedesco-Silva, Maria Gerbase-DeLima
The study aimed to investigate the impact of HLA-DPB1 allelic and molecular mismatches on the occurrence of acute rejection (AR) and low 5-year graft function (5Y-GF) in first kidney transplant (KT) recipients. This is a single center retrospective study of 130 deceased donor KT recipients transplanted between 2014 and 2016. HLA-DPB1 allelic MM and the following molecular MM (mMM) were analyzed: expression MM with the high expression G allele in the donor; T cell epitope MM (TCE MM); epitope MM (EMM), considering all six hypervariable regions (EMM-ABCDEF HVR), or only ABEF regions (EMM-ABEF HVR); eplet MM (EpMM); antibody-verified eplet MM (AbVer EpMM); and solvent accessible amino acid MM (SAMM)...
March 2023: HLA
https://read.qxmd.com/read/36406393/deciphering-the-potential-of-a-plant-growth-promoting-endophyte-rhizobium-sp-wyj-e13-and-functional-annotation-of-the-genes-involved-in-the-metabolic-pathway
#36
JOURNAL ARTICLE
Xiaoping Huang, Zhanghui Zeng, Zhehao Chen, Xiaxiu Tong, Jie Jiang, Chenjing He, Taihe Xiang
Plant growth-promoting rhizobacteria (PGPR) are well-acknowledged root endophytic bacteria used for plant growth promotion. However, which metabolites produced by PGPR could promote plant growth remains unclear. Additionally, which genes are responsible for plant growth-promoting traits is also not elucidated. Thus, as comprehensive understanding of the mechanism of endophyte in growth promotion is limited, this study aimed to determine the metabolites and genes involved in plant growth-promotion. We isolated an endophytic Rhizobium sp...
2022: Frontiers in Microbiology
https://read.qxmd.com/read/36400435/overview-of-the-medical-management-of-the-critically-ill-patient
#37
JOURNAL ARTICLE
Rebecca H Martinez, Kathleen D Liu, J Matthew Aldrich
The medical management of the critically ill patient focuses predominantly on treatment of the underlying condition ( e g , sepsis or respiratory failure). However, in the past decade, the importance of initiating early prophylactic treatment for complications arising from care in the intensive care unit setting has become increasingly apparent. As survival from critical illness has improved, there is an increased prevalence of postintensive care syndrome-defined as a decline in physical, cognitive, or psychologic function among survivors of critical illness...
December 2022: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/36341249/editorial-the-abcdef-bundle-laying-the-foundations-for-long-term-wellness-in-icu-survivors
#38
EDITORIAL
Maria Vargas, Pasquale Buonanno, Katarzyna Kotfis, Annachiara Marra
No abstract text is available yet for this article.
2022: Frontiers in Medicine
https://read.qxmd.com/read/36149467/-robotic-assisted-mobilization-for-an-effective-mobilization-in-a-covid-19-patient-with-ecmo-treatment
#39
REVIEW
F Dieterich, J Perras, W Popp, M Ahrens, S Wirth
An effective (early) mobilization in COVID-19 intensive care patients with ECMO treatment is very important. Sedation, extracorporeal procedures with the danger of circuit malfunction, large lumen ECMO cannulas with a risk of dislocation and a very severe neuromuscular weakness are factors that could deem mobilization beyond stage 1 of the ICU mobility score (IMS) in some cases difficult or impossible; however, early mobilization is a key point of the ABCDEF bundle to counteract pulmonary complications, neuromuscular dysfunction and enable recovery...
September 23, 2022: Anaesthesiologie
https://read.qxmd.com/read/36097918/-individualized-rehabilitation-strategies-for-patients-with-critical-pulmonary-diseases
#40
JOURNAL ARTICLE
Y Hu, Y Zhao, L X Xie
Individualized rehabilitation for patients with critical pulmonary diseases is a comprehensive intervention system that emphasizes individualized intervention with multidisciplinary specialties with different medical background support. On the basis of ensuring patients' safety, and evaluation of the right time for intervention, combined ABCDEF bundle strategies are used to implement individualized rehabilitation programs. In the process of rehabilitation treatment, we perform dynamic evaluation of the benefit and risk of individualized rehabilitation for patients suffering critical pulmonary diseases, and formulate adverse reaction prevention and control plans, and therefore to effectively improve the physical and psychological functions of patients, reducing complication and post- ICU syndrome, and promoting recovery...
September 12, 2022: Chinese Journal of Tuberculosis and Respiratory Diseases
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