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https://www.readbyqxmd.com/read/27935360/the-effect-of-postoperative-infection-on-survival-in-patients-with-glioblastoma
#1
Yi-Ren Chen, Beatrice Ugiliweneza, Eric Burton, Shiao Y Woo, Maxwell Boakye, Stephen Skirboll
OBJECTIVE Glioblastoma is a primary glial neoplasm with a median survival of approximately 1 year. There are anecdotal reports that postoperative infection may confer a survival advantage in patients with glioblastoma. However, only a few case reports in the literature, along with 2 retrospective cohort studies, show some potential link between infection and prolonged survival in patients with glioblastoma. The objective of this study was to evaluate the effect of postoperative infection in patients with glioblastoma using a large national database...
December 9, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27933451/association-between-adjuvant-chemotherapy-and-risk-of-acute-kidney-injury-in-elderly-women-diagnosed-with-early-stage-breast-cancer
#2
Shuling Li, Jiannong Liu, Beth A Virnig, Allan J Collins
PURPOSE: We studied elderly Medicare enrollees newly diagnosed with early-stage breast cancer to examine the association between adjuvant chemotherapy and acute kidney injury (AKI). METHODS: Using the linked Surveillance, Epidemiology, and End Results (SEER)-Medicare database, we conducted a retrospective cohort study including women diagnosed with stages I-III breast cancer at ages 66-89 years between 1992 and 2007. We performed one-to-one matching on time-dependent propensity score on the day of adjuvant chemotherapy initiation within 6 months after the first cancer-directed surgery based on the estimated probability of chemotherapy initiation at each day for each patient, using a Cox proportional hazards model...
December 8, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27926499/breast-carcinoma-in-situ-an-observational-study-of-tumor-subtype-treatment-and-outcomes
#3
Qi Wu, Juanjuan Li, Si Sun, Shan Zhu, Chuang Chen, Juan Wu, Qian Liu, Wen Wei, Shengrong Sun
BACKGROUND & AIMS: To evaluate the clinical presentation, treatment and outcome of patients with breast carcinoma in situ (BCIS) with special emphasis on the role of the tumor subtype and local treatment in these patients. METHODS: Using data obtained by the Surveillance, Epidemiology, and End Results (SEER) program from 2010-2013, a retrospective, population-based cohort study was conducted to investigate tumor subtype-specific differences in various characteristics, overall survival (OS) and breast cancer-specific mortality (BCSM)...
December 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27925181/estimation-of-the-tumor-size-at-cure-threshold-among-aggressive-non-small-cell-lung-cancers-nsclcs-evidence-from-the-surveillance-epidemiology-and-end-results-program-seer-and-the-national-lung-screening-trial-nlst
#4
Deborah L Goldwasser
The National Lung Screening Trial (NLST) demonstrated that non-small cell lung cancer (NSCLC) mortality can be reduced by a program of annual CT screening in high-risk individuals. However, CT screening regimens and adherence vary, potentially impacting the lung cancer mortality benefit. We defined the NSCLC cure threshold as the maximum tumor size at which a given NSCLC would be curable due to early detection. We obtained data from 518,234 NSCLCs documented in the U.S. SEER cancer registry between 1988 and 2012 and 1,769 NSCLCs detected in the NLST...
December 7, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27924652/risk-of-second-cancers-in-survivors-of-prolymphocytic-leukemia-a-seer-data-analysis
#5
Mohamed Abd El-Fattah
No abstract text is available yet for this article.
December 7, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27922973/incidence-and-outcomes-of-dermatofibrosarcoma-protuberans-in-the-us-pediatric-population
#6
Gustavo A Rubio, Andrea Alvarado, David J Gerth, Jun Tashiro, Seth R Thaller
BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is a low-grade soft tissue sarcoma. In the pediatric population, DFSP is exceedingly rare. Aim of this study was to describe the epidemiology and clinical outcomes in a large pediatric cohort. METHODS: Surveillance, Epidemiology, and End Results (SEER) database (1973-2010) was analyzed for all patients with dermatofibrosarcoma occurring in patients <20 years of age. Data were extracted based on age, gender, race, anatomic site, histology, stage, treatment modalities, and survival...
December 5, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27921315/imputing-estrogen-receptor-er-status-in-a-population-based-cancer-registry-a-sensitivity-analysis
#7
Rebecca Andridge, Anne-Michelle Noone, Nadia Howlader
Breast cancers are clinically heterogeneous based on tumor markers. The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program provides baseline data on these tumor markers for reporting cancer burden and trends over time in the US general population. These tumor markers, however, are often prone to missing observations. In particular, estrogen receptor (ER) status, a key biomarker in the study of breast cancer, has been collected since 1992 but historically was not well-reported, with missingness rates as high as 25% in early years...
December 5, 2016: Statistics in Medicine
https://www.readbyqxmd.com/read/27915203/adjuvant-radiation-therapy-and-survival-for-adenoid-cystic-carcinoma-of-the-breast
#8
Jia-Yuan Sun, San-Gang Wu, Shan-Yu Chen, Feng-Yan Li, Huan-Xin Lin, Yong-Xiong Chen, Zhen-Yu He
PURPOSE: The assess the clinical value of different types of surgical procedures and further analyze the effect of adjuvant radiation therapy (RT) for adenoid cystic carcinoma (ACC) of the breast. METHODS: Patients with ACC of the breast were identified using a population-based national registration database (Surveillance, Epidemiology, and End Results, SEER). The Kaplan-Meier method and Cox regression models were performed to determine the impact of the surgical procedures and adjuvant RT associated with cause-specific survival (CSS) and overall survival (OS)...
December 1, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27913438/quantifying-the-dynamics-of-field-cancerization-in-tobacco-related-head-and-neck-cancer-a-multiscale-modeling-approach
#9
Marc D Ryser, Walter T Lee, Neal E Ready, Kevin Z Leder, Jasmine Foo
High rates of local recurrence in tobacco-related head and neck squamous cell carcinoma (HNSCC) are commonly attributed to unresected fields of precancerous tissue. Because they are not easily detectable at the time of surgery without additional biopsies, there is a need for noninvasive methods to predict the extent and dynamics of these fields. Here, we developed a spatial stochastic model of tobacco-related HNSCC at the tissue level and calibrated the model using a Bayesian framework and population-level incidence data from the Surveillance, Epidemiology, and End Results (SEER) registry...
October 20, 2016: Cancer Research
https://www.readbyqxmd.com/read/27905233/measuring-compassionate-care-views-of-healthcare-staff
#10
Stephanie Tierney, Kate Seers, Joanne Reeve, Liz Tutton
Aim To explore healthcare professionals' views of measuring compassionate care. Method As part of a grounded theory study participants, who were healthcare professionals involved in the care of patients with type 2 diabetes, were invited to discuss the topic of compassionate care measurement through semi-structured interviews and focus groups. Results Measuring compassionate care was regarded as problematic because of its complex nature. Categories identified in the data that reflect this difficulty include distinguishing compassionate care from other concepts, relying on informal indicators, making the subjective objective, incorporating external influences and putting a measurement tool to use...
December 1, 2016: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/27903960/survival-outcomes-and-surgical-intervention-of-small-intestinal-neuroendocrine-tumors-a-population-based-retrospective-study
#11
Lunpo Wu, Jianfei Fu, Li Wan, Jie Pan, Sanchuan Lai, Jing Zhong, Daniel C Chung, Liangjing Wang
BACKGROUND: Small intestinal neuroendocrine tumors (SiNETs) without distant metastasis typically behave in an indolent manner, but there can be heterogeneity. We aimed to define the survival outcomes and impacts of surgical intervention. METHODS: A retrospective cohort study was conducted by using data from the Surveillance, Epidemiology, and End Results (SEER) database. Clinicopathologic features were analyzed in 4407 patients between 2000 and 2012. The cancer specific survival (CSS) was calculated by the Kaplan-Meier method...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27903497/association-between-screening-and-the-thyroid-cancer-epidemic-in-south-korea-evidence-from-a-nationwide-study
#12
Sohee Park, Chang-Mo Oh, Hyunsoon Cho, Joo Young Lee, Kyu-Won Jung, Jae Kwan Jun, Young-Joo Won, Hyun-Joo Kong, Kui Son Choi, You Jin Lee, Jin Soo Lee
OBJECTIVE:  To investigate whether screening for thyroid cancer led to the current "epidemic" in South Korea. DESIGN:  Review of the medical records of nationally representative samples of patients with a diagnosis of thyroid cancer in 1999, 2005, and 2008. SETTING:  Sample cases were randomly selected from South Korea's nationwide cancer registry, using a systematic sampling method after stratification by region. PARTICIPANTS:  5796 patients with thyroid cancer were included (891 in 1999, 2355 in 2005, and 2550 in 2008)...
November 30, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27900490/discordance-between-original-and-central-laboratories-in-er-and-her2-results-in-a-diverse-population-based-sample
#13
Jennifer J Griggs, Ann S Hamilton, Kendra L Schwartz, Weiqiang Zhao, Paul H Abrahamse, Dafydd G Thomas, Julie M Jorns, Rachel Jewell, Maria E Sibug Saber, Reina Haque, Steven J Katz
PURPOSE: To investigate the discordance between original and central laboratories in estrogen receptor (ER) status, in tumors originally deemed to be ER-negative, and in HER2 status in a diverse population-based sample. METHODS: In a follow-up study of 1785 women with Stage I-III breast cancer diagnosed between 2005 and 2007 in the Detroit and Los Angeles County SEER registry catchment areas, participants were asked to consent to reassessment of ER (in tumors originally deemed to be ER-negative) and HER2 status on archival tumor samples approximately four years after diagnosis...
November 29, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27896676/what-is-the-incidence-of-suicide-in-patients-with-bone-and-soft-tissue-cancer-suicide-and-sarcoma
#14
Brianna L Siracuse, George Gorgy, Jeremy Ruskin, Kathleen S Beebe
BACKGROUND: Patients with cancer in the United States are estimated to have a suicide incidence that is approximately twice that of the general population. Patients with bone and soft tissue cancer often have physical impairments and activity limitations develop that reduce their quality of life, which may put them at high risk for depression, anxiety, and suicidal ideation. To our knowledge, there have been no large studies determining incidence of suicide among patients with bone and soft tissue cancer; this information might allow screening of certain high-risk groups...
November 28, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27894752/trends-in-cervical-cancer-incidence-in-younger-us-women-from-2000-to-2013
#15
Daniel C Beachler, Joseph E Tota, Michelle I Silver, Aimée R Kreimer, Allan Hildesheim, Nicolas Wentzensen, Mark Schiffman, Meredith S Shiels
OBJECTIVE: This study aimed to assess the temporal trends in invasive cervical cancer (ICC) incidence rates among 21-25year-olds. US guidelines no longer recommend screening prior to age 21, and concerns have been raised that delayed screening initiation may increase ICC incidence among young women. METHODS: This study utilized ICC incidence data from 18 US population-based cancer registries in SEER from 2000 to 2013 and Pap test prevalence data from the Behavioral Risk Factor Surveillance System from 1996 to 2012...
November 25, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27891822/does-radiotherapy-still-have-a-role-in-unresected-biliary-tract-cancer
#16
Erqi L Pollom, Muthuraman Alagappan, Lesley S Park, Alice S Whittemore, Albert C Koong, Daniel T Chang
The benefits of radiotherapy for inoperable biliary tract cancer remain unclear due to the lack of randomized data. We evaluated the impact of radiotherapy on survival in elderly patients using the SEER-Medicare database. Patients in the SEER-Medicare database with inoperable biliary tract tumors diagnosed between 1998 and 2011 were included. We used multivariate logistic regression to evaluate factors associated with treatment selection, and multivariate Cox regression and propensity score matching to evaluate treatment selection in relation to subsequent survival...
November 28, 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27891701/depression-treatment-and-healthcare-expenditures-among-elderly-medicare-beneficiaries-with-newly-diagnosed-depression-and-incident-breast-colorectal-or-prostate-cancer
#17
Monira Alwhaibi, Usha Sambamoorthi, Suresh Madhavan, James T Walkup
OBJECTIVES: Depression is associated with high healthcare expenditures, and depression treatment may reduce healthcare expenditures. However, to date, there have not been any studies on the effect of depression treatment on healthcare expenditures among cancer survivors. Therefore, this study examined the association between depression treatment and healthcare expenditures among elderly with depression and incident cancer. METHODS: The current study utilized a retrospective longitudinal study design using the linked Surveillance, Epidemiology and End Results (SEER)-Medicare database...
November 28, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27888421/triple-negative-breast-cancer-has-worse-overall-survival-and-cause-specific-survival-than-non-triple-negative-breast-cancer
#18
Xiaoxian Li, Jing Yang, Limin Peng, Aysegul A Sahin, Lei Huo, Kevin C Ward, Ruth O'Regan, Mylin A Torres, Jane L Meisel
PURPOSE: The current American Joint Committee on Cancer (AJCC) staging manual uses tumor size, lymph node, and metastatic status to stage breast cancer across different subtypes. We examined the prognosis of triple-negative breast cancer (TNBC) versus non-TNBC within the same stages and sub-stages to evaluate whether TNBC had worse prognosis than non-TNBC. METHODS: We reviewed the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) data and identified 158,358 patients diagnosed with breast cancer from 2010 to 2012...
November 25, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27887797/mortality-burden-and-prognosis-of-thin-melanomas-overall-and-by-subcategory-of-thickness-seer-registry-data-1992-2013
#19
Shoshana M Landow, Annie Gjelsvik, Martin A Weinstock
BACKGROUND: Thin melanomas cause a high death toll despite excellent prognosis. OBJECTIVE: We examined melanoma mortality burden and prognosis by categories of thickness within Surveillance, Epidemiology, and End Results (SEER) 13 Registry 1992-2013. METHODS: We divided 49,319 stage I and II melanoma cases diagnosed between 1992 and 2003 into T1 through T4 and then subdivided T1 into 0.01-0.25 mm, 0.26-0.50 mm, 0.51-0.75 mm, and 0.76-1...
November 22, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27885685/gastric-and-small-intestine-gastrointestinal-stromal-tumors-do-outcomes-differ
#20
Katherine Giuliano, Neeraja Nagarajan, Joseph Canner, Alireza Najafian, Christopher Wolfgang, Eric Schneider, Christian Meyer, Anne Marie Lennon, Fabian M Johnston, Nita Ahuja
BACKGROUND AND OBJECTIVES: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Previous literature has suggested that small intestine GISTs are more aggressive than gastric GISTs. Our primary objective was to compare the outcomes of gastric and small intestine GISTs in the decade after approval of imatinib for treatment. METHODS: The SEER database was queried for cases of gastric and small intestine GIST between the years 2002 and 2012, using the ICD-O-3 histology code 8936...
November 25, 2016: Journal of Surgical Oncology
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