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https://www.readbyqxmd.com/read/29140483/integrative-whole-person-oncology-care-in-the-uk
#1
Catherine Zollman, Axel Walther, Helen E Seers, Rachel C Jolliffe, Marie J Polley
The term "whole-person cancer care"-an approach that addresses the needs of the person as well as treating the disease-is more widely understood in the United Kingdom than its synonym "integrative oncology." The National Health Service (NHS) provides free access to care for all, which makes it harder to prioritize NHS funding of whole-person medicine, where interventions may be multimodal and lacking in cost-effectiveness data. Despite this, around 30% of cancer patients are known to use some form of complementary or alternative medicine (CAM)...
November 1, 2017: Journal of the National Cancer Institute. Monographs
https://www.readbyqxmd.com/read/29140422/multidisciplinary-clinic-approach-improves-overall-survival-outcomes-of-patients-with-metastatic-germ-cell-tumors
#2
C Albany, N Adra, A C Snavely, C Cary, T A Masterson, R S Foster, K Kesler, T M Ulbright, L Cheng, M Chovanec, F Taza, K Ku, M J Brames, N H Hanna, L H Einhorn
Background: To report our experience utilizing a multidisciplinary clinic (MDC) at Indiana University (IU) since the publication of the International Germ Cell Cancer Collaborative Group (IGCCCG), and to compare our overall survival to that of the National Cancer Institute (NCI) Surveillance, Epidemiology, and End Results (SEER) Program. Patients and Methods: We conducted a retrospective analysis of all patients with metastatic germ cell tumor (GCT) seen at IU from 1998-2014...
November 10, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29139055/downstream-breast-imaging-following-screening-mammography-in-medicare-patients-with-advanced-cancer-a-population-based-study
#3
Gelareh Sadigh, Richard Duszak, Kevin C Ward, Renjian Jiang, Jeffrey M Switchenko, Kimberly E Applegate, Ruth C Carlos
BACKGROUND: Screening tests are generally not recommended in patients with advanced cancer and limited life expectancy. Nonetheless, screening mammography still occurs and may lead to follow-up testing. OBJECTIVE: We assessed the frequency of downstream breast imaging following screening mammography in patients with advanced colorectal or lung cancer. DESIGN: Population-based study. PARTICIPANTS: The study included continuously enrolled female fee-for-service Medicare beneficiaries ≥65 years of age with advanced colorectal (stage IV) or lung (stage IIIB-IV) cancer reported to a Surveillance, Epidemiology, and End Results (SEER) registry between 2000 and 2011...
November 14, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29137429/survival-rate-variation-with-different-histological-subtypes-of-poor-prognostic-male-anal-squamous-cell-carcinoma-a-population-based-study
#4
Zihao Wan, Zhihao Huang, Vikash Vikash, Kelash Rai, Sindhu Vikash, Liaobin Chen, Jingfeng Li
Background and objective: The prognosis of male anal squamous cell carcinoma (MASCC) and female anal squamous cell carcinoma (FASCC) is variable. The influence of tumor subtype on the survival rate and gender is poorly known. Our study is the largest population-based study and aims to outline the difference in survival between MASCC and FASCC patients. Methods: A retrospective population-based study was performed to compare the disease-specific mortalities (DSMs) between genders related to the tumor subtypes...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137247/the-influence-of-marital-status-on-survival-in-patients-with-oral-tongue-squamous-cell-carcinoma
#5
Wei Sun, Zeting Qiu, Wulin Tan, Zhongqi Liu, Zhongxing Wang, Wenqi Huang, Minghui Cao
Marital status was found to be an independent prognostic factor for survival in several cancers. However related researches of oral tongue squamous cell carcinoma (OTSCC) are still rare. We explored the Surveillance, Epidemiology, and End Results (SEER) program and finally identified 14,194 patients with OTSCC. Kaplan-Meier analysis and multivariate Cox regression models were used to distinguish risk factors for overall survival (OS) and tumor cause-specific survival (TCSS). Widowed patients had the highest percentage of female, highest average ages and more prevalence with localized SEER Stage significantly, while patients in the single group were younger than other groups...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29135774/creating-a-national-provider-identifier-npi-to-unique-physician-identification-number-upin-crosswalk-for-medicare-data
#6
Helen M Parsons, Lindsey R Enewold, Robert Banks, Michael J Barrett, Joan L Warren
INTRODUCTION: Many health services researchers are interested in assessing long term, individual physician treatment patterns, particularly for cancer care. In 2007, Medicare changed the physician identifier used on billed services from the Unique Physician Identification Number (UPIN) to the National Provider Identifier (NPI), precluding the ability to use Medicare claims data to evaluate individual physician treatment patterns across this transition period. METHODS: Using the 2007-2008 carrier (physician) claims from the linked Surveillance, Epidemiology and End Results (SEER) cancer registry-Medicare data and Medicare's NPI and UPIN Directories, we created a crosswalk that paired physician NPIs included in SEER-Medicare data with UPINs...
December 2017: Medical Care
https://www.readbyqxmd.com/read/29133264/comparative-analysis-of-clinical-treatment-and-survival-characteristics-of-basaloid-and-squamous-cell-carcinoma-of-the-esophagus
#7
Aitua Salami, Abbas E Abbas, Roman Petrov, Nirag Jhala, Charles T Bakhos
BACKGROUND: Basaloid squamous cell carcinoma (BSC) is a rare variant of squamous cell carcinoma (SqCC) of the esophagus. Even though pathologically thought to be more aggressive than SqCC, there is discrepancy in the literature regarding the outcomes of BSC compared to SqCC. STUDY DESIGN: A retrospective cohort study conducted using the SEER database. All patients with a histologic diagnosis of BSC and SqCC between 2004 and 2013 were included. We compared treatment and survival characteristics of patients with BSC and SqCC...
November 10, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29132798/the-impact-of-racial-ethnic-disparities-on-survival-for-children-and-adolescents-with-extremity-sarcomas-a-population-based-study
#8
Michael Joseph, Emma C Hamilton, Andrea Hayes-Jordan, Winston W Huh, Mary T Austin
PURPOSE: The purpose of this study was to determine whether racial/ethnic disparities exist in disease presentation, treatment, and survival among children and adolescents with extremity sarcoma. METHODS: The Surveillance, Epidemiology, and End Results (SEER) data were analyzed for patients <20years old with soft-tissue extremity sarcomas from 1973 to 2013. Multivariate logistic regression was performed to determine the association between race/ethnicity and disease stage at presentation and likelihood of surgical resection...
October 12, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29132615/prediction-of-lung-cancer-patient-survival-via-supervised-machine-learning-classification-techniques
#9
Chip M Lynch, Behnaz Abdollahi, Joshua D Fuqua, Alexandra R de Carlo, James A Bartholomai, Rayeanne N Balgemann, Victor H van Berkel, Hermann B Frieboes
Outcomes for cancer patients have been previously estimated by applying various machine learning techniques to large datasets such as the Surveillance, Epidemiology, and End Results (SEER) program database. In particular for lung cancer, it is not well understood which types of techniques would yield more predictive information, and which data attributes should be used in order to determine this information. In this study, a number of supervised learning techniques is applied to the SEER database to classify lung cancer patients in terms of survival, including linear regression, Decision Trees, Gradient Boosting Machines (GBM), Support Vector Machines (SVM), and a custom ensemble...
December 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29131529/clinicopathological-characteristics-and-survival-outcomes-in-pleomorphic-lobular-breast-carcinoma-of-the-breast-a-seer-population-based-study
#10
Li-Peng Yang, He-Fen Sun, Yang Zhao, Meng-Ting Chen, Nong Zhang, Wei Jin
The purpose of this study was to explore the clinicopathological features and survival outcome of pleomorphic lobular carcinoma (PLC) of breast, we identified 131 PLC patients and 460,109 invasive ductal carcinoma (IDC) patients in the Surveillance, Epidemiology, and End Result (SEER) database. PLCs presented with increased lymph node involvement, older age, higher AJCC stage and grade, and lower median survival months (PLC 84 ± 51.03 vs. IDC 105.2 ± 64.39 P < 0.01). Compared to IDC patients, PLC patients were more inclined to be treated with mastectomy...
November 13, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29127719/critical-evaluation-of-the-american-joint-commission-on-cancer-ajcc-8th-edition-staging-system-for-patients-with-hepatocellular-carcinoma-hcc-a-surveillance-epidemiology-end-results-seer-analysis
#11
Sivesh K Kamarajah, Timothy L Frankel, Christopher Sonnenday, Clifford S Cho, Hari Nathan
BACKGROUND: Recently, the American Joint Committee on Cancer (AJCC) released its 8th edition changes to the staging system for hepatocellular cancer (HCC). We sought to validate the 8th edition staging system and compare the performance to the 7th edition using a population-based data set. METHODS: Using the Surveillance, Epidemiology and End Results (SEER) database (1998-2013), patients undergoing resection or transplant for non-metastatic HCC were identified. Overall survival was estimated using the Kaplan-Meier method and compared using log-rank tests...
November 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29126815/analysis-of-suicide-risk-in-patients-with-penile-cancer-and-review-of-the-literature
#12
REVIEW
William G Simpson, Zachary Klaassen, Rita P Jen, William M Hughes, Durwood E Neal, Martha K Terris
The treatment for penile cancer has been shown to cause harmful psychiatric symptoms as well as have detrimental effects on well-being. In the past several years, alternatives to total or partial penectomy have emerged, such as chemotherapy, radiation, penile sparing, and laser ablation therapies. A more specific breakdown for penile cancer is in order as the therapy has the potential for life changing surgery. We examined the Surveillance, Epidemiology, and End Results (SEER) database (1973-2013), comprising 28% of the United States population...
October 3, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29125868/local-thoracic-therapy-improve-prognosis-for-stage-iv-non-small-cell-lung-cancer-patients-combined-with-chemotherapy-a-surveillance-epidemiology-and-end-results-database-analysis
#13
Kaitai Liu, Dawei Zheng, GuoDong Xu, Zhennan Du, Shibo Wu
Patients with stage IV non-small cell lung cancer (NSCLC) comprise a heterogeneous group, and the optimal treatment for this group of patients is complex and debatable. We aimed to assess the effect of local thoracic therapy combined with chemotherapy on cancer specific survival (CSS). To evaluate the CSS of four subgroups of patients with stage IV NSCLC according to four different treatment modalities: combined modality of Chemotherapy, Surgery, and Radiation (Chem+Sur+RT), Chemotherapy and Radiation (Chem+RT), Chemotherapy and Surgery (Chem+Sur), and Chemotherapy only (Chem Only) by analyzing the Surveillance, Epidemiology, and End Results (SEER)-registered database...
2017: PloS One
https://www.readbyqxmd.com/read/29124911/first-north-american-validation-and-head-to-head-comparison-of-four-preoperative-nomograms-for-prediction-of-lymph-node-invasion-before-radical-prostatectomy
#14
Marco Bandini, Michele Marchioni, Raisa S Pompe, Zhe Tian, Giorgio Gandaglia, Nicola Fossati, Firas Abdollah, Markus Graefen, Francesco Montorsi, Fred Saad, Shahrokh F Shariat, Alberto Briganti, Pierre I Karakiewicz
OBJECTIVES: To perform a head-to-head comparison of four nomograms, namely the Cagiannos, the 2012-Briganti, the Godoy and the online-Memorial Sloan Kettering Cancer Center (MSKCC), for prediction of lymph node invasion (LNI) in a North American population. MATERIALS & METHODS: 19,775 clinically localized prostate cancer (PCa) patients underwent radical prostatectomy and pelvic lymph node dissection (PLND) were identified within the Surveillance Epidemiology and End Results (SEER) database...
November 10, 2017: BJU International
https://www.readbyqxmd.com/read/29123252/surgical-management-and-prognostic-prediction-of-adenocarcinoma-of-jejunum-and-ileum
#15
Xin Xie, Zhangjian Zhou, Yongchun Song, Chengxue Dang, Hao Zhang
We conducted a retrospective study based on the Surveillance, Epidemiology, and End Results Program (SEER) database to establish a novel nomogram prognostic prediction system and to estimate the association between overall survival and prognostic factors, as well as to explore surgical treatment strategies for adenocarcinoma of the jejunum and ileum. A total of 883 patients from the SEER database were included in this study. Eight potential prognostic factors were included in a nomogram model and discriminatory power and accuracy were examined using the Harrell's C-index and Akaike Information Criterion (AIC) index...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29121104/evaluation-of-the-major-changes-in-eighth-edition-of-the-american-joint-committee-on-cancer-pathological-staging-for-prostate-cancer-treated-with-prostatectomy
#16
Wen-Jun Xiao, Yao Zhu, Bo Dai, Ding-Wei Ye
This study aimed to evaluate the major changes of the eighth edition of the American Joint Committee on Cancer (AJCC) pathologic staging for prostate cancer treated with radical prostatectomy. A total of 138,176 patients diagnosed with prostate adenocarcinoma undergoing radical prostatectomy were selected from the Surveillance, Epidemiology and End Results (SEER) database during 2004-2014 period. Excluded were cases with incomplete or unavailable staging, PSA and Gleason score information. Two subgroups were established: group a, T2 stage with PSA≥20ng/ml; group b, T2 stage with Gleason score grade group 5 and PSA<20ng/ml...
2017: PloS One
https://www.readbyqxmd.com/read/29119423/meningioma-and-breast-cancer-survival-of-patients-with-synchronous-and-metachronous-meningioma-and-breast-cancer
#17
José Pedro Lavrador, Marta Valente Pinto, Luís Mascarenhas Lemos, Catarina Ribeiro, André Peralta Santos
The prognosis of the association between Breast Cancer (BC) and Meningioma (M) is unknown. To evaluate the survival impact of tumor exposure sequence in patients with both tumors. Patients were divided in groups according to the tumors sequence: BC before M (group 1), synchronous BC + M (group 2) and BC after M (group 3). The SEER database was used. Demographics, meningioma and breast cancer variables were analyzed. The primary outcome was oncological survival. A total of 1715 patients were included (median follow-up:84 months)...
November 8, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29119353/impact-of-microinvasion-on-breast-cancer-mortality-in-women-with-ductal-carcinoma-in-situ
#18
Victoria Sopik, Ping Sun, Steven A Narod
BACKGROUND: Ductal carcinoma in situ (DCIS) is a neoplastic proliferation of epithelial cells which is confined within the basement membrane of the mammary ductal-lobular system. It is of interest to determine to what extent the potential to metastasize increases for DCIS patients when the basement membrane is breached (i.e. microinvasion is present). METHODS: We retrieved the records of 525,395 women who had either first primary DCIS or small (≤ 2.0 cm) node-negative invasive breast cancer in the Surveillance, Epidemiology and End Results (SEER) registries database (1990-2013)...
November 8, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29118529/pediatric-testicular-cancer-two-decades-of-saudi-national-data
#19
REVIEW
Mohammed Abomelha
Pediatric testicular cancer is exceedingly rare. There are no data available touching Saudi children. The aim of the study is to determine the trends and patterns of testicular cancer among Saudi children over a period of 20 years. The national database of the Saudi Cancer Registry (SCR) on pediatric testicular cancer over the last two decades was examined including epidemiological and histological patterns. From 1994 to 2013, 82 cases of testicular cancer among Saudi children aged 1-14 years were accumulated at the SCR...
October 2017: Urology Annals
https://www.readbyqxmd.com/read/29118232/healthcare-utilization-and-costs-during-the-initial-phase-of-care-among-elderly-women-with-breast-cancer
#20
Ami Vyas, S Suresh Madhavan, Usha Sambamoorthi, Xiaoyun Lucy Pan, Michael Regier, Hannah Hazard, Sita Kalidindi
Background: Understanding the patterns of healthcare utilization and costs during the initial phase of care (12 months after breast cancer [BC] diagnosis) in older women (aged ≥65 years) is crucial in the allocation of Medicare resources. The objective of this study was to determine healthcare utilization and costs during the initial phase of care in older, female, Medicare fee-for-service beneficiaries diagnosed with BC, and to determine the factors associated with higher costs. Methods: A retrospective observational study using the SEER-Medicare linked database was conducted in 69,307 women aged ≥66 years diagnosed with primary incident BC in 2003-2009 to determine healthcare utilization, average costs, and costs for specific services during the initial phase of care...
November 2017: Journal of the National Comprehensive Cancer Network: JNCCN
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