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https://www.readbyqxmd.com/read/27823637/migration-of-dendritic-cells-to-the-lymph-nodes-and-its-enhancement-to-drive-anti-tumor-responses
#1
REVIEW
Narges Seyfizadeh, Ravikumar Muthuswamy, Duane A Mitchell, Stefan Nierkens, Nayer Seyfizadeh
Better prognoses associated with increased T cell infiltration of tumors, as seen with chimeric antigen receptor (CAR) T cell therapies and immune checkpoint inhibitors, portray the importance and potential of the immune system in controlling tumors. This has rejuvenated the field of cancer immunotherapy leading to an increasing number of immunotherapies developed for cancer patients. Dendritic Cells (DCs) vaccines represent an appealing option for cancer immunotherapy since DCs have the ability to circumvent tolerance to tumors by its adjuvant properties and to induce memory T cells that can become persistent after initial tumor clearance to engage potential metastatic tumors...
November 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27808433/adaptation-of-exercise-induced-stress-in-well-trained-healthy-young-men
#2
Lonneke M JanssenDuijghuijsen, Jaap Keijer, Marco Mensink, Kaatje Lenaerts, Lars Ridder, Stefan Nierkens, Shirley W Kartaram, Martie C M Verschuren, Raymond H H Pieters, Richard Bas, Renger F Witkamp, Harry J Wichers, Klaske van Norren
Strenuous exercise induces different stress-related physiological changes, potentially including changes in intestinal barrier function. In the Protégé Study (ISRCTN14236739; www.isrctn.com) we determined the test-retest repeatability in responses to exercise in well-trained individuals. Eleven well-trained males (27 ± 4 years old) completed an exercise protocol that consisted of intensive cycling intervals, followed by an overnight fast and an additional 90 min cycling phase at 50% Wmax the next morning...
November 3, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27702800/excellent-t-cell-reconstitution-and-survival-provided-atg-exposure-is-low-or-absent-after-pediatric-cord-blood-transplantation
#3
Rick Admiraal, Caroline A Lindemans, Charlotte van Kesteren, Marc B Bierings, A Birgitta Versluys, Stefan Nierkens, Jaap Jan Boelens
Successful immune reconstitution (IR) is associated with improved outcomes following pediatric cord blood transplantation (CBT). Usage and timing of anti-thymocyte globulin (ATG), introduced to the conditioning to prevent graft-versus-host-disease and graft failure, negatively influences T-cell IR. We studied the relation between ATG exposure, IR and clinical outcomes. All pediatric patients receiving a first CBT between 2004-2015 at the University Medical Center Utrecht were included. ATG-exposure measures were determined with a validated PK-model...
October 4, 2016: Blood
https://www.readbyqxmd.com/read/27697775/strategies-before-during-and-after-hematopoietic-cell-transplantation-to-improve-t-cell-immune-reconstitution
#4
Coco de Koning, Stefan Nierkens, Jaap Jan Boelens
T-cell immune reconstitution (IR) after allogeneic hematopoietic cell transplantation (allo-HCT) is highly variable between patients and may take several months to even years. Patients with delayed or unbalanced T-cell IR have a higher probability of developing transplantation-related-morbidity, -mortality, and relapse of disease. Hence, there is a need for strategies to better predict and improve IR to reduce these limitations of allo-HCT. In this review, we provide an update of current and in near-future clinically relevant strategies before, during, and after transplantation to achieve successful T-cell IR...
October 3, 2016: Blood
https://www.readbyqxmd.com/read/27690673/systemic-inflammatory-immune-signatures-in-a-patient-with-crb1-linked-retinal-dystrophy
#5
Fleurieke Verhagen, Jonas Kuiper, Stefan Nierkens, S M Imhof, Timothy Radstake, Joke de Boer
OBJECTIVE: In this report we describe, for the first time, the activation of the peripheral immune compartment in a patient with a CRB1 linked retinal degenerative disease, masquerading as intermediate uveitis. METHODS: To monitor the immune system during systemic immunosuppressive treatment, given for the initial diagnosis of intermediate uveitis, blood samples were taken before and during therapy, for analysis of peripheral blood mononuclear cell-subsets and circulating immune mediators...
October 3, 2016: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/27616458/the-magnitude-of-cytokine-production-by-stimulated-cd56-cells-is-associated-with-early-stages-of-systemic-sclerosis
#6
Marta Cossu, Lenny van Bon, Stefan Nierkens, Chiara Bellocchi, Alessandro Santaniello, Harry Dolstra, Lorenzo Beretta, Timothy R D J Radstake
Immune activation is a hallmark of systemic sclerosis (SSc). However, the immunological alterations that occur in preclinical and non-fibrotic SSc and that differentiate these subjects from those with primary Raynaud's phenomenon (PRP) or healthy controls (HC) are poorly defined. We isolated CD56+ (NK/NKT-like) cells from HC, patients with PRP, early SSc (EaSSc) and definite SSc without skin or lung fibrosis. Cytokine production upon different activating stimuli was measured via a multiplex immuno assay. Clearly discriminative patterns among the different stages of SSc were most markedly observed after TLR1/2 stimulation, with increased IL-6, TNF-α and MIP-1α/CCL3 production in definite SSc patients as compared to HC and/or PRP...
September 8, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27257383/inequalities-in-the-impact-of-national-reimbursement-of-smoking-cessation-pharmacotherapy-and-the-influence-of-injunctive-norms-an-explorative-study
#7
Fiona E Benson, Gera E Nagelhout, Vera Nierkens, Marc C Willemsen, Karien Stronks
In 2011, the Dutch government reimbursed smoking cessation pharmacotherapy with behavioral therapy for quitting smokers. We investigate whether inequalities in the use of pharmacotherapy change and, if not, whether this is due to a relatively positive injunctive norm in lower socioeconomic status (SES) groups. A total of 75,415 participants aged ≥15 years from the Dutch Continuous Survey of Smoking Habits, 2009-2012, were considered with the following measures: SES (education/income), injunctive norm (mostly acceptable/neutral/mostly unacceptable), period (2011/all other years), and pharmacotherapy use (yes/no)...
2016: Substance Abuse: Research and Treatment
https://www.readbyqxmd.com/read/27159172/leukemia-free-survival-in-myeloid-leukemia-but-not-in-lymphoid-leukemia-is-predicted-by-early-cd4-reconstitution-following-unrelated-cord-blood-transplantation-in-children-a-multicenter-retrospective-cohort-analysis
#8
R Admiraal, R Chiesa, C A Lindemans, S Nierkens, M B Bierings, A B Versluijs, P Hiwarkar, J M Furtado Silva, P Veys, J J Boelens
No abstract text is available yet for this article.
May 9, 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27075842/impact-of-a-social-network-based-intervention-promoting-diabetes-self-management-in-socioeconomically-deprived-patients-a-qualitative-evaluation-of-the-intervention-strategies
#9
C Vissenberg, K Stronks, G Nijpels, P J M Uitewaal, B J C Middelkoop, M J E Kohinor, M A Hartman, V Nierkens
OBJECTIVE: There is a need for effective interventions that improve diabetes self-management (DSM) among socioeconomically deprived patients with type 2 diabetes. The group-based intervention Powerful Together with Diabetes (PTWD) aimed to increase social support for DSM and decrease social influences hindering DSM (eg, peer pressure, social norms) in patients living in deprived neighbourhoods. Through a qualitative process evaluation, this paper aims to study whether this intervention changed social support and social influences, and which elements of the intervention contributed to this...
2016: BMJ Open
https://www.readbyqxmd.com/read/26867732/phenotypic-variability-in-patients-with-ada2-deficiency-due-to-identical-homozygous-r169q-mutations
#10
MULTICENTER STUDY
Joris M Van Montfrans, Esther A R Hartman, Kees P J Braun, Eric A M Hennekam, Elisabeth A Hak, Paul J Nederkoorn, Willeke F Westendorp, Robbert G M Bredius, Wouter J W Kollen, Elisabeth H Schölvinck, G Elizabeth Legger, Isabelle Meyts, Adrian Liston, Klaske D Lichtenbelt, Jacques C Giltay, Gijs Van Haaften, Gaby M De Vries Simons, Helen Leavis, Cornelis J G Sanders, Marc B Bierings, Stefan Nierkens, Marielle E Van Gijn
OBJECTIVE: To determine the genotype-phenotype association in patients with adenosine deaminase-2 (ADA2) deficiency due to identical homozygous R169Q mutations inCECR1 METHODS: We present a case series of nine ADA2-deficient patients with an identical homozygous R169Q mutation. Clinical and diagnostic data were collected and available MRI studies were reviewed. We performed genealogy and haplotype analyses and measured serum ADA2 activity. ADA2 activity values were correlated to clinical symptoms...
May 2016: Rheumatology
https://www.readbyqxmd.com/read/26452036/natural-killer-cells-facilitate-prame-specific-t-cell-reactivity-against-neuroblastoma
#11
Lotte Spel, Jaap-Jan Boelens, Dirk M van der Steen, Nina J G Blokland, Max M van Noesel, Jan J Molenaar, Mirjam H M Heemskerk, Marianne Boes, Stefan Nierkens
Neuroblastoma is the most common solid tumor in children with an estimated 5-year progression free survival of 20-40% in stage 4 disease. Neuroblastoma actively avoids recognition by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). Although immunotherapy has gained traction for neuroblastoma treatment, these immune escape mechanisms restrain clinical results. Therefore, we aimed to improve neuroblastoma immunogenicity to further the development of antigen-specific immunotherapy against neuroblastoma...
November 3, 2015: Oncotarget
https://www.readbyqxmd.com/read/26451309/generation-of-a-cord-blood-derived-wilms-tumor-1-dendritic-cell-vaccine-for-aml-patients-treated-with-allogeneic-cord-blood-transplantation
#12
Colin de Haar, Maud Plantinga, Nina Jg Blokland, Niek P van Til, Thijs Wh Flinsenberg, Viggo F Van Tendeloo, Evelien L Smits, Louis Boon, Lotte Spel, Marianne Boes, Jaap Jan Boelens, Stefan Nierkens
The poor survival rates of refractory/relapsed acute myeloid leukemia (AML) patients after haematopoietic cell transplantation (HCT) requires the development of additional immune therapeutic strategies. As the elicitation of tumor-antigen specific cytotoxic T lymphocytes (CTLs) is associated with reduced relapses and enhanced survival, enhanced priming of these CTLs using an anti-AML vaccine may result in long-term immunity against AML. Cord blood (CB), as allogeneic HCT source, may provide a unique setting for such post-HCT vaccination, considering its enhanced graft-versus-leukemia (GvL) effects and population of highly responsive naïve T cells...
November 2015: Oncoimmunology
https://www.readbyqxmd.com/read/26341398/immune-reconstitution-after-allogeneic-hematopoietic-cell-transplantation-in-children
#13
REVIEW
Coco de Koning, Maud Plantinga, Paul Besseling, Jaap Jan Boelens, Stefan Nierkens
Allogeneic (allo) hematopoietic cell transplantation (HCT) has evolved into a potent curative treatment option for a variety of malignant and nonmalignant diseases. The occurrence of complications and mortality after allo-HCT is, however, still high and is strongly associated with immune reconstitution (IR). Therefore, detailed information on IR through immunomonitoring is crucial to improve survival chances after HCT. To date, information about the reconstituting immune system after allo-HCT in pediatric patients is mostly derived from routine standard-of-care measurements...
February 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/26317417/the-uptake-of-screening-for-type-2-diabetes-and-prediabetes-by-means-of-glycated-hemoglobin-versus-the-oral-glucose-tolerance-test-among-18-to-60-year-old-people-of-south-asian-origin-a-comparative-study
#14
COMPARATIVE STUDY
Irene G M van Valkengoed, Everlina M A Vlaar, Vera Nierkens, Barend J C Middelkoop, Karien Stronks
BACKGROUND: Direct comparisons of the effect of a glycated haemoglobin measurement or an oral glucose tolerance test on the uptake and yield of screening in people of South Asian origin have not been made. We evaluated this in 18 to 60-year-old South Asian Surinamese. MATERIALS AND METHODS: We invited 3173 South Asian Surinamese for an oral glucose tolerance test between June 18th 2009- December 31st 2009 and 2012 for a glycated hemoglobin measurement between April 19th 2010-November 11th, 2010...
2015: PloS One
https://www.readbyqxmd.com/read/26227135/smoking-cessation-behavioural-therapy-in-disadvantaged-neighbourhoods-an-explorative-analysis-of-recruitment-channels
#15
Fiona E Benson, Vera Nierkens, Marc C Willemsen, Karien Stronks
BACKGROUND: The optimum channel(s) used to recruit smokers living in disadvantaged neighbourhoods for smoking cessation behavioural therapy (SCBT) is unknown. This paper examines the channels through which smokers participating in a free, multi-session SCBT programme heard about and were referred to this service in a disadvantaged neighbourhood, and compares participants' characteristics and attendance between channels. METHODS: 109 participants, recruited from free SCBT courses in disadvantaged areas of two cities in the Netherlands, underwent repeated surveys...
2015: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/25943385/socioeconomic-inequalities-in-smoking-in-the-netherlands-before-and-during-the-global-financial-crisis-a-repeated-cross-sectional-study
#16
Fiona E Benson, Mirte A G Kuipers, Vera Nierkens, Jan-Willem Bruggink, Karien Stronks, Anton E Kunst
BACKGROUND: The Global Financial Crisis (GFC) increased levels of financial strain, especially in those of low socioeconomic status (SES). Financial strain can affect smoking behaviour. This study examines socioeconomic inequalities in current smoking and smoking cessation in The Netherlands before and during the Global Financial Crisis (GFC). METHODS: Participants were 66,960 Dutch adults (≥ 18 years) who took part in the annual national Health Survey (2004-2011)...
2015: BMC Public Health
https://www.readbyqxmd.com/read/25599896/a-panel-of-biomarkers-for-disease-severity-in-atopic-dermatitis
#17
LETTER
J L Thijs, S Nierkens, A Herath, C A F Bruijnzeel-Koomen, E F Knol, B Giovannone, M S de Bruin-Weller, D Hijnen
No abstract text is available yet for this article.
March 2015: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/25577471/diabetes-risk-reduction-in-overweight-first-degree-relatives-of-type-2-diabetes-patients-effects-of-a-low-intensive-lifestyle-education-program-dialert-a-randomized-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Wieke H Heideman, Maartje de Wit, Barend J C Middelkoop, Vera Nierkens, Karien Stronks, Arnoud P Verhoeff, Frank J Snoek
OBJECTIVES: To test the efficacy of a low-intensive lifestyle education program (DiAlert) for overweight first degree relatives of type 2 diabetes patients aimed at reducing diabetes risk. METHODS: Overweight first degree relatives of type 2 diabetes patients were randomly assigned to the DiAlert intervention (N=45) or control group who received leaflets (N=51). DiAlert consists of two group sessions and newsletters. Assessments were scheduled at baseline, three and nine months, with weight loss as primary outcome...
April 2015: Patient Education and Counseling
https://www.readbyqxmd.com/read/25378489/cognate-cd4-t-cell-licensing-of-dendritic-cells-heralds-anti-cytomegalovirus-cd8-t-cell-immunity-after-human-allogeneic-umbilical-cord-blood-transplantation
#19
T W H Flinsenberg, L Spel, M Jansen, D Koning, C de Haar, M Plantinga, R Scholman, M M van Loenen, S Nierkens, L Boon, D van Baarle, M H M Heemskerk, J J Boelens, M Boes
UNLABELLED: Reactivation of human cytomegalovirus (CMV) is hazardous to patients undergoing allogeneic cord blood transplantation (CBT), lowering survival rates by approximately 25%. While antiviral treatment ameliorates viremia, complete viral control requires CD8+ T-cell-driven immunity. Mouse studies suggest that cognate antigen-specific CD4+ T-cell licensing of dendritic cells (DCs) is required to generate effective CD8+ T-cell responses. For humans, this was not fully understood...
January 15, 2015: Journal of Virology
https://www.readbyqxmd.com/read/25135597/increased-prevalence-of-gastrointestinal-viruses-and-diminished-secretory-immunoglobulin-a-levels-in-antibody-deficiencies
#20
A A J M van de Ven, W J M Janssen, L S Schulz, A M van Loon, K Voorkamp, E A M Sanders, J G Kusters, S Nierkens, M Boes, A M J Wensing, J M van Montfrans
PURPOSE: Gastrointestinal disease occurs frequently in antibody deficiencies. This study aims to explore the relation between gastrointestinal infections and mucosal homeostasis in patients with antibody deficiencies. METHODS: We performed an observational study including 54 pediatric antibody deficient patients (48 % CVID, 41 % CVID-like, 11 % XLA) and 66 healthy controls. Clinical symptom scores and stool samples were collected prospectively. Stool samples were evaluated for bacteria, parasites, viruses, secretory IgA- and for calprotectin levels...
November 2014: Journal of Clinical Immunology
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