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https://www.readbyqxmd.com/read/29238243/analysis-of-time-motion-and-heart-rate-in-elite-male-and-female-beach-handball
#1
Basilio Pueo, Jose M Jimenez-Olmedo, Alfonso Penichet-Tomas, Manuel Ortega Becerra, Jose J Espina Agullo
Beach handball is a spectacular new team sport; however, scientific knowledge about the demands in beach handball is very low. Consequently, the aim of this study was to analyze the physical demands of elite beach handball players by means of time-motion analysis with GPS technology and physiological response with Heart Rate (HR). Both male (n = 12) and female (n = 12) players from the Spanish Beach Handball National Team were recruited for this study. The sample consisted in four matches of two 10-min periods each...
December 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29235458/the-ideal-harvest-time-for-seeds-of-hybrid-maize-zea-mays-l-xy335-and-zd958-produced-in-multiple-environments
#2
Riliang Gu, Li Li, Xiaolin Liang, Yanbo Wang, Tinglu Fan, Ying Wang, Jianhua Wang
To identify the ideal harvest time (IHT) for the seed production of XY335 and ZD958, six seed-related traits were evaluated in seeds harvested at 11 harvest stages in 8 environments. Standard germination (SG), accelerated aging germination (AAG) and cold test germination (CTG) were vigor traits; hundred-seed weight (HSW) and seed moisture content (SMC) were physiological traits; and ≥10 °C accumulated temperature from pollination to harvest (AT10ph) was an ecological trait. All the traits were significantly affected by harvest stage...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29209947/copy-number-variation-arising-from-gene-conversion-on-the-human-y-chromosome
#3
Wentao Shi, Andrea Massaia, Sandra Louzada, Ruby Banerjee, Pille Hallast, Yuan Chen, Anders Bergström, Yong Gu, Steven Leonard, Michael A Quail, Qasim Ayub, Fengtang Yang, Chris Tyler-Smith, Yali Xue
We describe the variation in copy number of a ~ 10 kb region overlapping the long intergenic noncoding RNA (lincRNA) gene, TTTY22, within the IR3 inverted repeat on the short arm of the human Y chromosome, leading to individuals with 0-3 copies of this region in the general population. Variation of this CNV is common, with 266 individuals having 0 copies, 943 (including the reference sequence) having 1, 23 having 2 copies, and two having 3 copies, and was validated by breakpoint PCR, fibre-FISH, and 10× Genomics Chromium linked-read sequencing in subsets of 1234 individuals from the 1000 Genomes Project...
December 5, 2017: Human Genetics
https://www.readbyqxmd.com/read/29205592/increase-of-prostaglandin-e2-in-the-reversal-of-ductal-constriction-after-polyphenol-restriction
#4
Izabele Vian, Paulo Zielinsky, Ana Maria Zílio, Maximiliano I Schaun, Camila Brum, Kenya Venusa Lampert, Nataly De Ávila, Giovana Baldissera, Tamires Mezzomo Klanovicz, Karina Zenki, Jesus Zurita-Peralta, Alessandro Olszewski, Antonio Piccoli, Luiz Henrique Nicoloso, Natássia Sulis, Luiza Van Der Sand, Melissa Markoski
OBJECTIVE: Anti-inflammatory substances that inhibit the synthesis of prostaglandins, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and polyphenol-rich foods, can cause constriction of the fetal ductus arteriosus. This study aimed to test the hypothesis that reversal of fetal ductal constriction after maternal restriction of polyphenol-rich foods, in the third trimester of pregnancy, is accompanied by increased prostaglandin E2(PGE2) plasma levels. METHOD: A controlled clinical trial was designed...
December 5, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29203490/mutations-in-genes-encoding-penicillin-binding-proteins-and-efflux-pumps-play-a-role-in-%C3%AE-lactam-resistance-in-helicobacter-cinaedi
#5
Emiko Rimbara, Shigetarou Mori, Hyun Kim, Masato Suzuki, Keigo Shibayama
β-Lactams are often used to treat Helicobacter cinaedi infections; however, the mechanism underlying β-lactam resistance is unknown. In this study, we investigated β-lactam resistance in a H. cinaedi strain, MRY12-0051 (MIC of AMX and CRO: 32 and 128 μg/ml; obtained from human feces). Based on a comparative whole genome analysis of MRY12-0051 and the CRO-susceptible H. cinaedi strain MRY08-1234 (MIC of AMX and CRO: 1 and 4 μg/ml; obtained from human blood), we identified five mutations in genes encoding penicillin-binding proteins (PBPs), including two in pbpA, one in pbp2, and two in ftsI Transformation and penicillin-binding assays indicated that CRO resistance was mainly associated with mutations in pbpA; mutations in ftsI also led to increased resistance to AMX...
December 4, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29170310/13%C3%A2-prophylactic-antibiotics-for-penetrating-injury-a-review-of-practice-at-a-major-trauma-centre-literature-review-and-recommendations
#6
Marharyta Kamarova, Richard Kendall
BACKGROUND: There is a lack of clarity regarding the use of prophylactic antibiotics for patients presenting with penetrating injuries. A structured literature review and review of penetrating injury records in an MTC was undertaken with a view to help guide clinical practice. METHOD: Searches were conducted on Medline (1946-2017), Embase (1974-2017), and Cochrane (up to 2017) using key words pertaining to penetrating trauma, prophylactic antibiotics and infection...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29167390/early-elevated-troponin-levels-after-ischemic-stroke-suggests-a-cardioembolic-source
#7
Shadi Yaghi, Andrew D Chang, Brittany A Ricci, Mahesh V Jayaraman, Ryan A McTaggart, Morgan Hemendinger, Priya Narwal, Katarina Dakay, Brian MacGrory, Shawna M Cutting, Tina M Burton, Christopher Song, Emile Mehanna, Matthew Siket, Tracy E Madsen, Michael Reznik, Alexander E Merkler, Michael P Lerario, Hooman Kamel, Mitchell S V Elkind, Karen L Furie
BACKGROUND AND PURPOSE: Elevated cardiac troponin is a marker of cardiac disease and has been recently shown to be associated with embolic stroke risk. We hypothesize that early elevated troponin levels in the acute stroke setting are more prevalent in patients with embolic stroke subtypes (cardioembolic and embolic stroke of unknown source) as opposed to noncardioembolic subtypes (large-vessel disease, small-vessel disease, and other). METHODS: We abstracted data from our prospective ischemic stroke database and included all patients with ischemic stroke during a 22-month period...
November 22, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29160917/visualization-of-calcium-phosphate-cement-in-teeth-by-zero-echo-time-1-h-mri-at-high-field
#8
Weiqiang Dou, Simone Mastrogiacomo, Andor Veltien, Hamdan S Alghamdi, X Frank Walboomers, Arend Heerschap
(1) H magnetic resonance imaging (MRI) by a zero echo time (ZTE) sequence is an excellent method to image teeth. Calcium phosphate cement (CPC) materials are applied in the restoration of tooth lesions, but it has not yet been investigated whether they can be detected by computed tomography (CT) or MRI. The aim of this study was to optimize high-field ZTE imaging to enable the visualization of a new CPC formulation implanted in teeth and to apply this in the assessment of its decomposition in vivo. CPC was implanted in three human and three goat teeth ex vivo and in three goat teeth in vivo...
November 21, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29137197/effect-of-age-on-glasgow-coma-scale-in-patients-with-moderate-and-severe-traumatic-brain-injury-an-approach-with-propensity-score-matched-population
#9
Cheng-Shyuan Rau, Shao-Chun Wu, Yi-Chun Chen, Peng-Chen Chien, Hsiao-Yun Hsieh, Pao-Jen Kuo, Ching-Hua Hsieh
Background: The most widely used methods of describing traumatic brain injury (TBI) are the Glasgow Coma Scale (GCS) and the Abbreviated Injury Scale (AIS). Recent evidence suggests that presenting GCS in older patients may be higher than that in younger patients for an equivalent anatomical severity of TBI. This study aimed to assess these observations with a propensity-score matching approach using the data from Trauma Registry System in a Level I trauma center. Methods: We included all adult patients (aged ≥20 years old) with moderate to severe TBI from 1 January 2009 to 31 December 2016...
November 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29133374/the-rin-mc-fusion-of-mads-box-transcription-factors-has-transcriptional-activity
#10
Shan Li, Huijinlan Xu, Zheng Ju, Dongyan Cao, Hongliang Zhu, Daqi Fu, Donald Grierson, Guozheng Qin, Yunbo Luo, Benzhong Zhu
Fruit development and ripening is regulated by genetic and environmental factors and is of critical importance for seed dispersal, reproduction and fruit quality. Tomato rin mutant fruit have a classic ripening-inhibited phenotype, which is attributed to a genomic DNA deletion resulting in the fusion of two truncated transcription factors, RIN and MC. In wild-type fruit, RIN, a MADS-box transcription factor, is a key regulator of the ripening gene expression network with hundreds of gene targets controlling changes in color, flavor, texture and taste during tomato fruit ripening; MC, on the other hand, has low expression in fruit, and the potential functions of the RIN-MC fusion gene in ripening remain unclear...
November 13, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29119244/enterovirus-associated-changes-in-blood-transcriptomic-profiles-of-children-with-genetic-susceptibility-to-type-1-diabetes
#11
Niina Lietzen, Le T T An, Maria K Jaakkola, Henna Kallionpää, Sami Oikarinen, Juha Mykkänen, Mikael Knip, Riitta Veijola, Jorma Ilonen, Jorma Toppari, Heikki Hyöty, Riitta Lahesmaa, Laura L Elo
AIMS/HYPOTHESIS: Enterovirus infections have been associated with the development of type 1 diabetes in multiple studies, but little is known about enterovirus-induced responses in children at risk for developing type 1 diabetes. Our aim was to use genome-wide transcriptomics data to characterise enterovirus-associated changes in whole-blood samples from children with genetic susceptibility to type 1 diabetes. METHODS: Longitudinal whole-blood samples (356 samples in total) collected from 28 pairs of children at increased risk for developing type 1 diabetes were screened for the presence of enterovirus RNA...
November 8, 2017: Diabetologia
https://www.readbyqxmd.com/read/28965944/predictors-of-outcome-after-primary-total-joint-replacement
#12
Markus Weber, Benjamin Craiovan, Michael L Woerner, Timo Schwarz, Joachim Grifka, Tobias F Renkawitz
BACKGROUND: Total hip and knee replacements are frequently performed curative treatment options in end-stage arthritis. In this study, we analyzed clinical outcome, complications, and predictors of outcome in modern joint replacement. METHODS: In a retrospective analysis of over 2000 primary total hip and knee replacements from our institutional joint registry, responder rates for positive outcome as defined by the OMERACT-OARSI criteria, postoperative complication rates, and patient-reported outcome measures (EQ-5D, WOMAC) within the first year were compared between hip and knee replacements...
September 7, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28965348/adulteration-of-proprietary-chinese-medicines-and-health-products-with-undeclared-drugs-experience-of-a-tertiary-toxicology-laboratory-in-hong-kong
#13
Chor Kwan Ching, Sammy Pak Lam Chen, Hencher Han Chih Lee, Ying Hoo Lam, Sau Wah Ng, Mo Lung Chen, Magdalene Huen Yin Tang, Suzanne Suk San Chan, Candy Wai Yan Ng, Jana Wing Lan Cheung, Tina Yee Ching Chan, Nike Kwai Cheung Lau, Yeow Kuan Chong, Tony Wing Lai Mak
AIMS: Proprietary Chinese medicines (pCMs) and health products, generally believed to be natural and safe, are gaining popularity worldwide. However, the safety of pCMs and health products has been severely compromised by the practice of adulteration. The current study aimed to examine the problem of adulteration of pCMs and health products in Hong Kong. METHODS: The present study was conducted in a tertiary referral clinical toxicology laboratory in Hong Kong. All cases involving the use of pCMs or health products, which were subsequently confirmed to contain undeclared adulterants, from 2005 to 2015 were reviewed retrospectively...
October 1, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28959440/prevalence-and-phenotype-of-diabetes-and-prediabetes-using-fasting-glucose-vs-hba1c-in-a-caribbean-population
#14
Nigel Unwin, Christina Howitt, Angela Mc Rose, T Alafia Samuels, Anselm Jm Hennis, Ian R Hambleton
BACKGROUND: Both fasting plasma glucose (FPG) and HbA1c are recommended for the diagnosis of diabetes and prediabetes by the American Diabetes Association (ADA), and for diabetes by the World Health Organization. The ADA guidance is influential on clinical practice in many developing countries, including in the Caribbean and Latin America. We aimed to compare the prevalence and characteristics of individuals identified as having diabetes and prediabetes by FPG and HbA1c in a predominantly African ancestry Caribbean population...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/28912560/the-srgap2-snps-their-haplotypes-and-g%C3%A2-%C3%A3-%C3%A2-e-interactions-on-serum-lipid-traits
#15
Liu Miao, Rui-Xing Yin, Jin-Zhen Wu, Shuo Yang, Wei-Xiong Lin, Shang-Ling Pan
Maonan nationality is a relatively conservative and isolated minority in China. Little is known about the association of the Slit-Robo Rho GTPase activating protein 2 gene (SRGAP2) single nucleotide polymorphisms (SNPs) and serum lipid levels in the Chinese populations. This study was performed to clarify the association of the SRGAP2 rs2483058 and rs2580520 SNPs and their haplotypes with serum lipid traits in the Maonan and Han populations. Genotyping of the 2 SNPs was performed in 2444 unrelated subjects (Han, 1210 and Maonan, 1234) by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28903801/s-aureus-infections-in-chicago-2006-2014-increase-in-ca-mssa-and-decrease-in-mrsa-incidence
#16
M Ellen Acree, Ethan Morgan, Michael Z David
OBJECTIVE To examine trends in Staphylococcus aureus infections in adults and children at a single academic center in 2006-2014. DESIGN Retrospective cohort study. SETTING Inpatient, outpatient, and emergency department settings in a private, tertiary referral center. PATIENTS Patients with an infection culture that grew S. aureus in January 1, 2006, through March 31, 2014. METHODS The first isolate per year for each patient was classified as community-associated (CA-), healthcare-associated (HA-), or HA-community-onset S...
October 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28895733/evidence-for-a-double-well-in-the-first-triplet-excited-state-of-2-thiouracil
#17
Daisuke Koyama, Matthew J Milner, Andrew J Orr-Ewing
The computationally predicted presence of two structurally distinct minima in the first triplet excited (T1) state of 2-thiouracil (2TU) is substantiated by sub-picosecond transient vibrational absorption spectroscopy (TVAS) in deuterated acetonitrile solution. Following 300 nm ultraviolet excitation to the second singlet excited state of 2TU, a transient infrared absorption band centered at 1643 cm(-1) is observed within our minimum time resolution of 0.3 ps. It is assigned either to 2TU molecules in the S1 state or to vibrationally hot T1-state molecules, with the latter assignment more consistent with recent computational and experimental studies...
September 26, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28890321/general-hospital-costs-in-england-of-medical-and-psychiatric-care-for-patients-who-self-harm-a-retrospective-analysis
#18
Apostolos Tsiachristas, David McDaid, Deborah Casey, Fiona Brand, Jose Leal, A-La Park, Galit Geulayov, Keith Hawton
BACKGROUND: Self-harm is an extremely common reason for hospital presentation. However, few estimates have been made of the hospital costs of assessing and treating self-harm. Such information is essential for planning services and to help strengthen the case for investment in actions to reduce the frequency and effects of self-harm. In this study, we aimed to calculate the costs of hospital medical care associated with a self-harm episode and the costs of psychosocial assessment, together with identification of the key drivers of these costs...
October 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28864973/the-role-of-oxytocin-in-social-buffering-what-do-primate-studies-add
#19
Catherine Crockford, Tobias Deschner, Roman M Wittig
The ability to maintain close social bonds impacts on reproductive success, longevity, stress and health in social mammals, including humans (Silk et al., Curr Biol 20(15):1359-1361, 2010; Crockford et al., Horm Behav 53(1):254-265, 2008; Wittig et al., Horm Behav 54(1):170-177, 2008; Archie et al., Proc R Soc B 281(1793):20141261, 2014; Cameron et al., Proc Natl Acad Sci U S A 106:13850-13853, 2009; Schülke et al., Curr Biol 20:2207-2210, 2010; Silk et al., Science 302:1231-1234, 2003; Holt-Lunstad et al...
September 2, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28833329/population-pharmacokinetics-and-bayesian-estimation-of-tacrolimus-exposure-in-chinese-liver-transplant-patients
#20
B Chen, H-Q Shi, X-X Liu, W-X Zhang, J-Q Lu, B-M Xu, H Chen
WHAT IS KNOWN AND OBJECTIVES: Tacrolimus (TAC) is widely used as part of immunosuppressive regimens. There is great interindividual variation on the disposition of TAC. The aim of this study was to develop a population pharmacokinetic (PPK) model for Chinese liver transplant patients and evaluate genetic polymorphism and other possible factors on the PK parameters. The exposure of TAC is to be estimated through Bayesian modelling. METHODS: A total of 47 sets of rich-time PK and 1234 conventional therapeutic drug monitoring (TDM) data were collected from 125 Chinese liver transplant patients...
August 17, 2017: Journal of Clinical Pharmacy and Therapeutics
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