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Sagi Shashar, Maayan Yitshak-Sade, Roman Sonkin, Victor Novack, Eli Jaffe
BACKGROUND: Published annual estimates report a global burden of 2.5 million snakebite cases and >100,000 deaths. In Israel, envenomations are the third most frequent cause of poisonings that are of moderate to major clinical severity. Most studies focus on the clinical descriptions of snakebites in tropical climates, and we sought to investigate the association between snakebite frequency and meteorological parameters. OBJECTIVE: We sought to investigate the seasonality of snakebites and evaluate the association between increasingly common heat waves and other meteorological parameters and snakebite frequency in a semiarid nontropical climate...
April 13, 2018: Journal of Emergency Medicine
Sherry Kit Wa Chan, Stephanie Wing Yan Chan, Herbert H Pang, Kang K Yan, Christy Lai Ming Hui, Wing Chung Chang, Edwin Ho Ming Lee, Eric Yu Hai Chen
Importance: Patients with schizophrenia have a substantially higher suicide rate than the general public. Early intervention (EI) services improve short-term outcomes. However, little is known about the association of EI with suicide reduction in the long term. Objective: To examine the association of a 2-year EI service with suicide reduction in patients with first-episode schizophrenia-spectrum (FES) disorders during 12 years and the risk factors for early and late suicide...
April 4, 2018: JAMA Psychiatry
Akihiro Shirakabe, Noritake Hata, Nobuaki Kobayashi, Hirotake Okazaki, Masato Matsushita, Yusaku Shibata, Suguru Nishigoori, Saori Uchiyama, Kazutaka Kiuchi, Fumitaka Okajima, Toshiaki Otsuka, Kuniya Asai, Wataru Shimizu
The prognostic impact of a decreased blood glucose level in acute heart failure (AHF) has not been sufficiently clarified. The data from 1234 AHF patients were examined in the present study. The blood glucose (BG) levels were evaluated at admission. The patients were divided into groups based on the following: with or without diabetes mellitus (DM), and BG level ≥ 200 mg/dl (elevated BG) or < 200 mg/dl (decreased BG). The elevated and decreased BG patients were further divided into another three groups: 200 mg/ml ≤ BG < 300 mg/dl (mild-elevated), 300 mg/ml ≤ BG < 400 mg/dl (moderate-elevated) and BG ≥ 400 mg/ml (severe-elevated); and 150 mg/ml ≤ BG < 200 mg/dl (mild-decreased), 100 mg/ml ≤ BG < 150 mg/dl (moderate-decreased) and BG < 100 mg/ml (severe-decreased), respectively...
March 22, 2018: Heart and Vessels
Nina V Palkola, Sari H Pakkanen, Oskari Heikinheimo, Jussi M Kantele, Anu Kantele
Mucosal antibodies constitute the first line of adaptive immune defence against invaders in the female genital tract (FGT), yet the sequence of events leading to their production is surprisingly poorly characterized. We explored the induction of pathogen-specific antibody-secreting cells (ASC) as a response to an acute infection in the upper FGT. We recruited 12 patients undergoing surgery due to an upper FGT infection (7/12 blood culture positive, 5/12 negative) and six healthy controls. Pathogens were sampled during surgery and PBMC collected in the acute phase of the disease (days 7-10)...
March 2, 2018: Journal of Reproductive Immunology
Mohammad R Ostovaneh, Bharath Ambale-Venkatesh, Tomoki Fuji, Hooman Bakhshi, Ravi Shah, Venkatesh L Murthy, Russell P Tracy, Eliseo Guallar, Colin O Wu, David A Bluemke, João A C Lima
BACKGROUND: The association of cardiovascular diseases (CVD) with liver fibrosis is poorly understood. We aim to assess the association of liver fibrosis by T1-mapping magnetic resonance imaging and CVD in MESA (Multi-Ethnic Study of Atherosclerosis). METHODS AND RESULTS: MESA enrolled 6814 participants free of clinical CVD at baseline (2000-2002). A subsample of participants underwent T1-mapping magnetic resonance imaging 10 years after the baseline (Y10 MESA exam, 2010-2012)...
March 2018: Circulation. Cardiovascular Imaging
Nandhini Srinivasan, Jin-Yao Teo, Yung-Ka Chin, Tiffany Hennedige, Damien M Tan, Albert S Low, Choon Hua Thng, Brian K P Goh
BACKGROUND: This systematic review was performed to assess the clinical utility of the Sendai Consensus Guidelines (SCG) and Fukuoka Consensus Guidelines (FCG) for intraductal papillary mucinous neoplasm (IPMN). METHODS: A computerized search of PubMed was performed to identify all the studies which evaluated the SCG and FCG in surgically resected, histologically confirmed IPMNs. RESULTS: Ten studies evaluating the FCG, 8 evaluating the SCG and 4 evaluating both guidelines were included...
February 24, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Wibhu Kutanan, Jatupol Kampuansai, Andrea Brunelli, Silvia Ghirotto, Pittayawat Pittayaporn, Sukhum Ruangchai, Roland Schröder, Enrico Macholdt, Metawee Srikummool, Daoroong Kangwanpong, Alexander Hübner, Leonardo Arias, Mark Stoneking
Tai-Kadai (TK) is one of the major language families in Mainland Southeast Asia (MSEA), with a concentration in the area of Thailand and Laos. Our previous study of 1234 mtDNA genome sequences supported a demic diffusion scenario in the spread of TK languages from southern China to Laos as well as northern and northeastern Thailand. Here we add an additional 560 mtDNA genomes from 22 groups, with a focus on the TK-speaking central Thai people and the Sino-Tibetan speaking Karen. We find extensive diversity, including 62 haplogroups not reported previously from this region...
February 26, 2018: European Journal of Human Genetics: EJHG
Apurva K Srivastava, Melinda G Hollingshead, Jeevan P Govindharajulu, Joseph M Covey, Dane Liston, Melanie A Simpson, James O Peggins, Donald P Bottaro, John J Wright, Robert J Kinders, James H Doroshow, Ralph E Parchment
The development of molecularly targeted agents has benefited from use of pharmacodynamic (PD) markers to identify "biologically effective doses" (BEDs) below maximum tolerable doses, yet this knowledge remains underutilized in selecting dosage regimens and in comparing the effectiveness of targeted agents within a class. We sought to establish preclinical proof-of-concept for such PD-based BED regimens and effectiveness comparisons using MET kinase small molecule inhibitors. Utilizing PD biomarker measurements of MET signaling (tumor pY1234/1235 MET/total MET ratio) in a Phase 0-like preclinical setting, we developed optimal dosage regimens for several MET kinase inhibitors and compared their antitumor efficacy in a MET-amplified gastric cancer xenograft model (SNU-5)...
February 14, 2018: Molecular Cancer Therapeutics
N D Clement, M Bardgett, D Weir, J Holland, C Gerrand, D J Deehan
AIMS: The primary aim of this study was to assess whether patient satisfaction one year after total knee arthroplasty (TKA) changed with longer follow-up. The secondary aims were to identify predictors of satisfaction at one year, persistence of patient dissatisfaction, and late onset dissatisfaction in patients that were originally satisfied at one year. PATIENTS AND METHODS: A retrospective cohort consisting of 1369 patients undergoing a primary TKA for osteoarthritis that had not undergone revision were identified from an established arthroplasty database...
February 2018: Bone & Joint Journal
Yong Wei, Zheng Zhang, Guotao Chen, Leilei Zhu, Hesong Jiang, Baibing Yang, Yun Chen, Yutian Dai, Quanbing Chen
OBJECTIVES: The association between aryl hydrocarbon receptor gene (AhR) polymorphism and male infertility risk remains conflicting. We conducted a meta-analysis to examine the AhR Arg554Lys polymorphism in relation to the susceptibility to male infertility. STUDY DESIGN: Studies concerning the association between AHR polymorphism and male infertility were searched and related information were extracted from the included studies. The STATA 12.0 software was used to perform a meta-analysis...
January 31, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Yuyu Liu, Lingli Deng, Cen Zhang, Fengqin Feng, Hui Zhang
In this work, the ethylcellulose/gelatin blends at various weight ratios in water/ethanol/acetic acid solution were electrospun to fabricate nanofibers with tunable physical properties. The solution compatibility was predicted based on Hansen solubility parameters and evaluated by rheological measurements. The physical properties were characterized by scanning electron microscopy, porosity, differential scanning calorimetry, thermogravimetry, Fourier transform infrared spectroscopy, and water contact angle...
February 9, 2018: Journal of Agricultural and Food Chemistry
Haitao Li, Xiaoting Zhou, Hongyi Tan, Yongbin Hu, Lemeng Zhang, Shuai Liu, Minhui Dai, Yi Li, Qian Li, Zhi Mao, Pinhua Pan, Xiaoli Su, Chengpin Hu
Background: Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a manifestation of systemic inflammation in the lungs, but the factors that trigger inflammation in ALI/ARDS are unclear. We hypothesized that neutrophil extracellular traps (NETs) contribute to the pathogenesis of acid aspiration-induced ALI/ARDS. Results: Analysis of bronchial aspirates from ARDS patients showed that NETs were significantly correlated with the degree of ARDS (r = -0...
January 5, 2018: Oncotarget
Christine Hsueh, Michelle Giuffrida, Philipp D Mayhew, J Brad Case, Ameet Singh, Eric Monnet, David E Holt, Megan Cray, Chiara Curcillo, Jeffrey J Runge
OBJECTIVE: To describe pet owner preferences within the veterinary community when choosing operative techniques for canine spay. STUDY DESIGN: Prospective survey. SAMPLE POPULATION: 1234 respondents from 5 veterinary university teaching hospitals in North America. METHODS: An electronic survey was distributed to faculty, students, and staff that currently are or previously were dog owners. Responses were analyzed to determine what spay technique respondents would choose for their own dogs...
February 5, 2018: Veterinary Surgery: VS
Khashayar Shahin, Majid Bouzari
Shigellosis (bacillary dysentery) is an acute enteric infection caused by members of Shigella genus. It causes annual deaths of approximately five million children in developing countries. Among Shigella spp., S. flexneri causes more serious forms of dysentery than other Shigella species. Due to the appearance of multidrug-resistant strains of Shigella spp., it is necessary to find alternative antimicrobial agents. The aims of this study were the isolation of a novel species-specific phage against S. flexneri and to evaluate its potential and efficacy for biocontrolling of S...
February 2018: Journal of Food Science and Technology
Serena C Houghton, JoAnn E Manson, Brian W Whitcomb, Susan E Hankinson, Lisa M Troy, Carol Bigelow, Elizabeth R Bertone-Johnson
BACKGROUND/OBJECTIVES: Women with premenstrual syndrome (PMS) are encouraged to reduce sugar and increase fiber intake to reduce symptoms. However, research supporting these recommendations is limited, and their role in PMS development is unclear. This study examines the relation between carbohydrate and fiber intake and the risk of PMS nested within the prospective Nurses' Health Study II cohort. SUBJECTS/METHODS: Carbohydrate and fiber intake were assessed at baseline and three additional times during follow up by food frequency questionnaire...
January 29, 2018: European Journal of Clinical Nutrition
A M Dueckelmann, D Fink, P Harter, V Heinzelmann, C Marth, M Mueller, A Reinthaller, K Tamussino, P Wimberger, J Sehouli
BACKGROUND: Ovarian, tubal, and peritoneal carcinomas primarily affect the peritoneal cavity, and they are typically diagnosed at an advanced tumor stage (Foley, Rauh-Hain, del Carmen in Oncology (Williston Park) 27:288-294, 2013). In the course of primary surgery, postoperative tumor residuals are, apart from the tumor stage, the strongest independent factors of prognosis (du Bois, Reuss, Pujade-Lauraine, Harter, Ray-Coquard, Pfisterer in Cancer 115:1234-1244, 2009). Due to improved surgical techniques, including the use of multi-visceral procedures, macroscopic tumor clearance can be achieved in oncological centers, in most cases (Harter, Muallem, Buhrmann et al in Gynecol Oncol 121:615-619, 2011)...
April 2018: Archives of Gynecology and Obstetrics
Sebastian Blecha, Frank Dodoo-Schittko, Susanne Brandstetter, Magdalena Brandl, Michael Dittmar, Bernhard M Graf, Christian Karagiannidis, Christian Apfelbacher, Thomas Bein
BACKGROUND: The acute respiratory distress syndrome (ARDS) is a life-threatening condition. In special situations, these critically ill patients must be transferred to specialized centers for escalating treatment. The aim of this study was to evaluate the quality of inter-hospital transport (IHT) of ARDS patients. METHODS: We evaluated medical and organizational aspects of structural and procedural quality relating to IHT of patients with ARDS in a prospective nationwide ARDS study...
January 15, 2018: Annals of Intensive Care
Nabil Shalabi, Malin Persson, Alf Månsson, Srikar Vengallatore, Dilson E Rassier
In this study, we measured the stiffness of skeletal muscle myofibrils in rigor. Using a custom-built atomic force microscope, myofibrils were first placed in a rigor state then stretched and shortened at different displacements (0.1-0.3 μm per sarcomere) and nominal speeds (0.4 and 0.8 μm/s). During stretching, the myofibril stiffness was independent of both displacement and speed (average of 987 nN/μm). During shortening, the myofibril stiffness was independent of displacement, but dependent on speed (1234 nN/μm at 0...
December 19, 2017: Biophysical Journal
Basilio Pueo, Jose M Jimenez-Olmedo, Alfonso Penichet-Tomas, Manuel Ortega Becerra, Jose J Espina Agullo
Beach handball is a spectacular new team sport; however, scientific knowledge about the demands in beach handball is very low. Consequently, the aim of this study was to analyze the physical demands of elite beach handball players by means of time-motion analysis with GPS technology and physiological response with Heart Rate (HR). Both male (n = 12) and female (n = 12) players from the Spanish Beach Handball National Team were recruited for this study. The sample consisted in four matches of two 10-min periods each...
December 2017: Journal of Sports Science & Medicine
Riliang Gu, Li Li, Xiaolin Liang, Yanbo Wang, Tinglu Fan, Ying Wang, Jianhua Wang
To identify the ideal harvest time (IHT) for the seed production of XY335 and ZD958, six seed-related traits were evaluated in seeds harvested at 11 harvest stages in 8 environments. Standard germination (SG), accelerated aging germination (AAG) and cold test germination (CTG) were vigor traits; hundred-seed weight (HSW) and seed moisture content (SMC) were physiological traits; and ≥10 °C accumulated temperature from pollination to harvest (AT10ph ) was an ecological trait. All the traits were significantly affected by harvest stage...
December 13, 2017: Scientific Reports
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