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https://www.readbyqxmd.com/read/28274232/perilipin-polymorphisms-are-risk-factors-for-the-development-of-obesity-in-adolescents-a-case-control-study
#1
Yavuz Tokgöz, Ishak Abdurrahman Işık, Soheil Akbari, Tuncay Kume, Oya Sayın, Esra Erdal, Nur Arslan
BACKGROUND: The variations in perilipin gene (PLIN) were previously associated with obesity. We examined the association of polymorphisms at the PLIN locus in adolescents with obesity and their connection with serum adipokines. METHODS: A total of 308 children (206 obese, 66.8% and 102 healthy control, 33.2%) between the ages of 10-18 years were included into the study. PLIN gene analysis [PLIN 1, PLIN 4, PLIN 6, PLIN 5'UTR-1234 C > G and PLIN 10171 A/T] were studied by Real Time-PCR...
March 9, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28262595/radiological-impact-of-natural-radioactivity-in-egyptian-phosphate-rocks-phosphogypsum-and-phosphate-fertilizers
#2
S M El-Bahi, A Sroor, Gehan Y Mohamed, N S El-Gendy
In this study, the activity concentrations of the natural radionuclides in phosphate rocks and its products were measured using a high- purity germanium detector (HPGe). The obtained activity results show remarkable wide variation in the radioactive contents for the different phosphate samples. The average activity concentration of (235)U, (238)U, (226)Ra, (232)Th and (40)K was found as (45, 1031, 786, 85 and 765Bq/kg) for phosphate rocks, (28, 1234, 457, 123 and 819Bq/kg) for phosphate fertilizers, (47, 663, 550, 79 and 870Bq/kg) for phosphogypsum and (25, 543, 409, 54 and 897Bq/kg) for single super phosphate respectively...
February 21, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28261104/circulating-micrornas-correlated-with-bone-loss-induced-by-45-days-of-bed-rest
#3
Shukuan Ling, Guohui Zhong, Weijia Sun, Fengji Liang, Feng Wu, Hongxing Li, Yuheng Li, Dingsheng Zhao, Jinping Song, Xiaoyan Jin, Xiaorui Wu, Hailin Song, Qi Li, Yinghui Li, Shanguang Chen, Jianghui Xiong, Yingxian Li
The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with bone loss induced by bed rest, and testify whether the selected miRNAs could reflect the bone mineral status of human after bed-rest. We analyzed plasma miRNA levels of 16 subjects after 45 days of -6° head-down tilt bed rest, which is a reliable model for the simulation of microgravity. We characterize the circulating miRNA profile in individuals after bed rest and identify circulating miRNAs which can best reflect the level of bone loss induced by bed rest...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28249094/effect-of-ischemic-postconditioning-during-primary-percutaneous-coronary-intervention-for-patients-with-st-segment-elevation-myocardial-infarction-a-randomized-clinical-trial
#4
Thomas Engstrøm, Henning Kelbæk, Steffen Helqvist, Dan Eik Høfsten, Lene Kløvgaard, Peter Clemmensen, Lene Holmvang, Erik Jørgensen, Frants Pedersen, Kari Saunamaki, Jan Ravkilde, Hans-Henrik Tilsted, Anton Villadsen, Jens Aarøe, Svend Eggert Jensen, Bent Raungaard, Hans E Bøtker, Christian J Terkelsen, Michael Maeng, Anne Kaltoft, Lars R Krusell, Lisette O Jensen, Karsten T Veien, Klaus Fuglsang Kofoed, Christian Torp-Pedersen, Kasper Kyhl, Lars Nepper-Christensen, Marek Treiman, Niels Vejlstrup, Kiril Ahtarovski, Jacob Lønborg, Lars Køber
Importance: Ischemic postconditioning of the heart during primary percutaneous coronary intervention (PCI) induced by repetitive interruptions of blood flow to the ischemic myocardial region immediately after reopening of the infarct-related artery may limit myocardial damage. Objective: To determine whether ischemic postconditioning can improve the clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI). Design, Setting, And Participants: In this multicenter, randomized clinical trial, patients with onset of symptoms within 12 hours, STEMI, and thrombolysis in myocardial infarction (TIMI) grade 0-1 flow in the infarct-related artery at arrival were randomized to conventional PCI or postconditioning...
March 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28242130/kennedy-s-disease-1234-scale-preliminary-design-and-test
#5
Ming Lu, Haixiao Guo, Dongsheng Fan
Kennedy's disease (KD), also known as spinal and bulbar muscular atrophy (SBMA), is a rare x-linked genetic disorder which is characterized by muscle weakness and atrophy. In previous clinical trials, KD patients had been assessed using the ALSFRS scale, which was specifically designed for ALS patients. However, the progression of KD is very slow, and thus, the ALSFRS does not accurately reflect changes in the clinical condition of KD patient. Here, we developed the KD 1234 scale which designed specially for KD...
February 24, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28224311/prevalence-incidence-and-sex-ratio-of-transsexualism-in-the-autonomous-region-of-madrid-spain-according-to-healthcare-demand
#6
Antonio Becerra-Fernández, José Miguel Rodríguez-Molina, Nuria Asenjo-Araque, María Jesús Lucio-Pérez, Miguel Cuchí-Alfaro, Eduardo García-Camba, Gilberto Pérez-López, Miriam Menacho-Román, María Carmen Berrocal-Sertucha, Domingo Ly-Pen, María Victorina Aguilar-Vilas
In recent years, different studies have provided estimates of the prevalence of transsexualism with very diverse results. The purpose of this study was to ascertain the prevalence, incidence, and sex ratio of transsexualism in the autonomous region of Madrid (Spain). A total of 1234 patients who attended from 2007 to the end of 2015 in the only Gender Identity Unit (GIU) in Madrid were analyzed. Sixty-three patients were excluded for various reasons; thus, 1171 could be included: 803 male-to-female (MtF) and 368 female-to-male (FtM) transsexual patients...
February 21, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28134344/swath-label-free-proteomics-analyses-revealed-the-roles-of-oxidative-stress-and-antioxidant-defensing-system-in-sclerotia-formation-of-polyporus-umbellatus
#7
Bing Li, Xiaofang Tian, Chunlan Wang, Xu Zeng, Yongmei Xing, Hong Ling, Wanqiang Yin, Lixia Tian, Zhixia Meng, Jihui Zhang, Shunxing Guo
Understanding the initiation and maturing mechanisms is important for rational manipulating sclerotia differentiation and growth from hypha of Polyporus umbellatus. Proteomes in P. umbellatus sclerotia and hyphae at initial, developmental and mature phases were studied. 1391 proteins were identified by nano-liquid chromatograph-mass spectrometry (LC-MS) in Data Dependant Acquisition mode, and 1234 proteins were quantified successfully by Sequential Window Acquisition of all THeoretical fragment ion spectra-MS (SWATH-MS) technology...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28114813/reproductive-health-counseling-delivered-to-women-living-with-hiv-in-the-united-states
#8
Runa H Gokhale, Heather Bradley, John Weiser
Advances in antiretroviral therapy (ART) and reproductive technologies have made transmission of HIV to partners and infants almost completely preventable. Comprehensive reproductive health counseling (CRHC) is an important component of care for women living with HIV, but few women report discussing reproductive health with an HIV care provider. We surveyed a probability sample of U.S. HIV care providers during 2013-2014. Of 2023 eligible providers, 1234 responded (64% adjusted provider response rate). We estimated the percentage delivering CRHC to their female patients...
January 23, 2017: AIDS Care
https://www.readbyqxmd.com/read/28056847/impact-of-diabetes-and-hypertension-on-cardiovascular-outcomes-in-patients-with-coronary-artery-disease-receiving-percutaneous-coronary-intervention
#9
Mao-Jen Lin, Chun-Yu Chen, Hau-De Lin, Han-Ping Wu
BACKGROUND: Percutaneous coronary intervention (PCI) is a necessary procedure commonly performed for patients with coronary artery disease (CAD). However, the impact of diabetes and hypertension on long-term outcomes of patients after receiving PCI has not yet been determined. METHODS: The data of 1234 patients who received PCI were collected prospectively, and patients were divided into four groups, including patients with and without DM and those with either DM or hypertension alone...
January 5, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28049363/circulating-chromogranin-b-levels-in-patients-with-acute-respiratory-failure-data-from-the-finnali-study
#10
Peder Langeland Myhre, Mats Stridsberg, Rita Linko, Marjatta Okkonen, Ståle Nygård, Geir Christensen, Ville Pettilä, Torbjørn Omland, Helge Røsjø
PURPOSE: Circulating chromogranin B (CgB) levels are increased in situations characterized by systemic and myocardial stress, but whether CgB provides prognostic information in patients with acute respiratory failure (ARF) is unknown. METHODS: We included 584 patients with ARF, defined as ventilatory support >6 h, and with blood samples available on Intensive Care Unit (ICU) admission and day 3 (n = 479). CgB levels were measured by radioimmunoassay and follow-up was 90 days...
January 3, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28029734/investigation-of-the-first-seven-reported-cases-of-candida-auris-a-globally-emerging-invasive-multidrug-resistant-fungus-united-states-may-2013-august-2016
#11
EDITORIAL
S Vallabhaneni, A Kallen, S Tsay, N Chow, R Welsh, J Kerins, S K Kemble, M Pacilli, S R Black, E Landon, J Ridgway, T N Palmore, A Zelzany, E H Adams, M Quinn, S Chaturvedi, J Greenko, R Fernandez, K Southwick, E Y Furuya, D P Calfee, C Hamula, G Patel, P Barrett, P Lafaro, E L Berkow, H Moulton-Meissner, J Noble-Wang, R P Fagan, B R Jackson, S R Lockhart, A P Litvintseva, T M Chiller
November 11, 2016/65(44);1234-1237. What is already known about this topic? Candida auris is an emerging pathogenic fungus that has been reported from at least a dozen countries on four continents during 2009-2015. The organism is difficult to identify using traditional biochemical methods, some isolates have been found to be resistant to all three major classes of antifungal medications, and C. auris has caused health care-associated outbreaks. What is added by this report? This is the first description of C...
January 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/27997455/cervical-cancer-screening-with-human-papillomavirus-dna-and-cytology-in-japan
#12
Yuri Sasaki, Osamu Iwanari, Ichiro Arakawa, Takuya Moriya, Yoshiki Mikami, Kuniko Iihara, Ryo Konno
OBJECTIVE: The aim of this study was to determine the value of human papillomavirus (HPV) testing for primary cervical cancer screening in Japan. METHODS: In total, 5065 women who underwent primary screening with cytology and HPV between January 2005 and December 2006 were enrolled. In the baseline phase, these women were stratified by age, and the rates of HPV-positive and abnormal cytology were compared between women younger than and older than 30 years. In the follow-up phase, women aged 20 to 69 years and cytology negative for intraepithelial lesions or malignancy at baseline were followed up until December 2011 (n = 2383)...
March 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27973378/erratum-water-science-and-technology-74-5-1227-1234-adaptation-of-microbial-communities-in-activated-sludge-to-1-decyl-3-methylimidazolium-bromide-dorota-gendaszewska-and-ewa-liwarska-bizukojc-doi-10-2166-wst-2016-317
#13
Ewa Liwarska-Bizukojc
No abstract text is available yet for this article.
December 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/27966433/operative-outcome-of-hong-kong-centenarians-with-hip-fracture
#14
M Y Cheung, A Wh Ho, S H Wong
INTRODUCTION: International clinical guidelines recommend early surgical treatment for geriatric patients with hip fracture. There are, however, few data concerning the operative outcome of centenarians. This study aimed to report the epidemiology of hip fracture and postoperative mortality rate, and to discuss whether operation is justified in centenarians in Hong Kong. METHODS: This observational study was carried out in all public hospitals of Hong Kong. All patients aged 100 years or above who underwent hip fracture surgery in any public hospital between 1 January 2010 and 31 December 2013 were included...
December 14, 2016: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/27900937/post-authorization-changes-in-the-safety-and-efficacy-assessment-recommended-indications-and-drug-quality-profile-of-adalimumab-a-chronological-overview
#15
Gergely Iványi, Romána Zelkó
OBJECTIVE: The intention of the present study was to demonstrate the postauthorization changes of adalimumab (European trade name: Humira), evaluating the variations in its safety, efficacy, and quality profile. METHODS: Type-II, major variations of the Summary of Product Characteristics (SmPC) from September 8, 2003 to November 19, 2015, were analyzed, which, according to Commission Regulation (EC) No. 1234/2008, have to reflect changes that may have a significant impact on the safety, efficacy, or quality profile of a medicinal product...
November 30, 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27887647/the-hide-and-seek-of-plasmodium-vivax-in-west-africa-report-from-a-large-scale-study-in-beninese-asymptomatic-subjects
#16
Philippe Poirier, Cécile Doderer-Lang, Pascal S Atchade, Jean-Philippe Lemoine, Marie-Louise Coquelin de l'Isle, Ahmed Abou-Bacar, Alexander W Pfaff, Julie Brunet, Lydia Arnoux, Elodie Haar, Denis Filisetti, Sylvie Perrotey, Nicodeme W Chabi, Casimir D Akpovi, Ludovic Anani, André Bigot, Ambaliou Sanni, Ermanno Candolfi
BACKGROUND: Plasmodium vivax is considered to be absent from western Africa, where the prevalence of Duffy-negative red blood cell phenotype proves to be high. Several studies have, however, detected P. vivax infection cases in this part of Africa, raising the question of what is the actual prevalence of P. vivax in local populations. METHODS: The presence of P. vivax was investigated in a large population of healthy blood donors in Benin using microscopy, serology and molecular detection...
November 25, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27876689/survey-email-scheduling-and-monitoring-in-ercts-sesame-a-digital-tool-to-improve-data-collection-in-randomized-controlled-clinical-trials
#17
Trygve Skonnord, Finn Steen, Holgeir Skjeie, Arne Fetveit, Mette Brekke, Atle Klovning
BACKGROUND: Electronic questionnaires can ease data collection in randomized controlled trials (RCTs) in clinical practice. We found no existing software that could automate the sending of emails to participants enrolled into an RCT at different study participant inclusion time points. OBJECTIVE: Our aim was to develop suitable software to facilitate data collection in an ongoing multicenter RCT of low back pain (the Acuback study). For the Acuback study, we determined that we would need to send a total of 5130 emails to 270 patients recruited at different centers and at 19 different time points...
November 22, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27850870/1234-impact-of-dextrose-dose-on-hypoglycemia-development-following-treatment-of-hyperkalemia
#18
Nicholas Farina, Christopher Anderson
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27837350/complete-mitochondrial-genomes-of-thai-and-lao-populations-indicate-an-ancient-origin-of-austroasiatic-groups-and-demic-diffusion-in-the-spread-of-tai-kadai-languages
#19
Wibhu Kutanan, Jatupol Kampuansai, Metawee Srikummool, Daoroong Kangwanpong, Silvia Ghirotto, Andrea Brunelli, Mark Stoneking
The Tai-Kadai (TK) language family is thought to have originated in southern China and spread to Thailand and Laos, but it is not clear if TK languages spread by demic diffusion (i.e., a migration of people from southern China) or by cultural diffusion, with native Austroasiatic (AA) speakers switching to TK languages. To address this and other questions, we obtained 1234 complete mtDNA genome sequences from 51 TK and AA groups from Thailand and Laos. We find high genetic heterogeneity across the region, with 212 different haplogroups, and significant genetic differentiation among different samples from the same ethnolinguistic group...
January 2017: Human Genetics
https://www.readbyqxmd.com/read/27770637/the-efficacy-of-intraoperative-autologous-platelet-gel-in-total-knee-arthroplasty-a-meta-analysis
#20
REVIEW
Ming-Jie Kuang, Chao Han, Jian-Xiong Ma, Fei Li, Jie Zhao, Lin Fu, Xin-Long Ma
PURPOSE: Autologous platelet gel, developed from fresh autologous blood, is a breakthrough in the promotion and acceleration of soft tissue and bone repair. The application of autologous platelet gel has been reported to improve haemostasis and promote function recovery. We screened the randomized controlled trials and controlled clinical trials of high quality to investigate whether autologous platelet gel makes a better performance for postoperative bleeding and functional recovery in patients after total knee arthroplasty...
December 2016: International Journal of Surgery
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