keyword
MENU ▼
Read by QxMD icon Read
search

1234

keyword
https://www.readbyqxmd.com/read/27900937/post-authorization-changes-in-the-safety-and-efficacy-assessment-recommended-indications-and-drug-quality-profile-of-adalimumab-a-chronological-overview
#1
Gergely Iványi, Romána Zelkó
OBJECTIVE: The intention of the present study was to demonstrate the postauthorization changes of adalimumab (European trade name: Humira), evaluating the variations in its safety, efficacy, and quality profile. METHODS: Type-II, major variations of the Summary of Product Characteristics (SmPC) from September 8, 2003 to November 19, 2015, were analyzed, which, according to Commission Regulation (EC) No. 1234/2008, have to reflect changes that may have a significant impact on the safety, efficacy, or quality profile of a medicinal product...
November 30, 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27887647/the-hide-and-seek-of-plasmodium-vivax-in-west-africa-report-from-a-large-scale-study-in-beninese-asymptomatic-subjects
#2
Philippe Poirier, Cécile Doderer-Lang, Pascal S Atchade, Jean-Philippe Lemoine, Marie-Louise Coquelin de l'Isle, Ahmed Abou-Bacar, Alexander W Pfaff, Julie Brunet, Lydia Arnoux, Elodie Haar, Denis Filisetti, Sylvie Perrotey, Nicodeme W Chabi, Casimir D Akpovi, Ludovic Anani, André Bigot, Ambaliou Sanni, Ermanno Candolfi
BACKGROUND: Plasmodium vivax is considered to be absent from western Africa, where the prevalence of Duffy-negative red blood cell phenotype proves to be high. Several studies have, however, detected P. vivax infection cases in this part of Africa, raising the question of what is the actual prevalence of P. vivax in local populations. METHODS: The presence of P. vivax was investigated in a large population of healthy blood donors in Benin using microscopy, serology and molecular detection...
November 25, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27876689/survey-email-scheduling-and-monitoring-in-ercts-sesame-a-digital-tool-to-improve-data-collection-in-randomized-controlled-clinical-trials
#3
Trygve Skonnord, Finn Steen, Holgeir Skjeie, Arne Fetveit, Mette Brekke, Atle Klovning
BACKGROUND: Electronic questionnaires can ease data collection in randomized controlled trials (RCTs) in clinical practice. We found no existing software that could automate the sending of emails to participants enrolled into an RCT at different study participant inclusion time points. OBJECTIVE: Our aim was to develop suitable software to facilitate data collection in an ongoing multicenter RCT of low back pain (the Acuback study). For the Acuback study, we determined that we would need to send a total of 5130 emails to 270 patients recruited at different centers and at 19 different time points...
November 22, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27850870/1234-impact-of-dextrose-dose-on-hypoglycemia-development-following-treatment-of-hyperkalemia
#4
Nicholas Farina, Christopher Anderson
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27837350/complete-mitochondrial-genomes-of-thai-and-lao-populations-indicate-an-ancient-origin-of-austroasiatic-groups-and-demic-diffusion-in-the-spread-of-tai-kadai-languages
#5
Wibhu Kutanan, Jatupol Kampuansai, Metawee Srikummool, Daoroong Kangwanpong, Silvia Ghirotto, Andrea Brunelli, Mark Stoneking
The Tai-Kadai (TK) language family is thought to have originated in southern China and spread to Thailand and Laos, but it is not clear if TK languages spread by demic diffusion (i.e., a migration of people from southern China) or by cultural diffusion, with native Austroasiatic (AA) speakers switching to TK languages. To address this and other questions, we obtained 1234 complete mtDNA genome sequences from 51 TK and AA groups from Thailand and Laos. We find high genetic heterogeneity across the region, with 212 different haplogroups, and significant genetic differentiation among different samples from the same ethnolinguistic group...
November 11, 2016: Human Genetics
https://www.readbyqxmd.com/read/27770637/the-efficacy-of-intraoperative-autologous-platelet-gel-in-total-knee-arthroplasty-a-meta-analysis
#6
REVIEW
Ming-Jie Kuang, Chao Han, Jian-Xiong Ma, Fei Li, Jie Zhao, Lin Fu, Xin-Long Ma
PURPOSE: Autologous platelet gel, developed from fresh autologous blood, is a breakthrough in the promotion and acceleration of soft tissue and bone repair. The application of autologous platelet gel has been reported to improve haemostasis and promote function recovery. We screened the randomized controlled trials and controlled clinical trials of high quality to investigate whether autologous platelet gel makes a better performance for postoperative bleeding and functional recovery in patients after total knee arthroplasty...
October 19, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27741340/secukinumab-self-administration-by-prefilled-syringe-maintains-reduction-of-plaque-psoriasis-severity-over-52-weeks-results-of-the-feature-trial
#7
Alice B Gottlieb, Andrew Blauvelt, Jörg C Prinz, Philemon Papanastasiou, Rashidkhan Pathan, Judit Nyirady, Todd Fox, Charis Papavassilis
BACKGROUND: Secukinumab, a human monoclonal antibody that selectively targets interleukin-17A, is highly efficacious in the treatment of moderate-to-severe psoriasis, starting at early time points, with a sustained effect and a favorable safety profile. METHODS: Patients with moderate-to-severe plaque psoriasis were randomized to secukinumab 300 mg, secukinumab 150 mg, or placebo self-administered by prefilled syringe at baseline, weeks 1, 2, and 3, and then every four weeks from week 4 to 48...
October 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27720248/allergen-specific-ige-to-food-molecular-components-and-age-from-early-childhood-to-adulthood
#8
M A Tosca, M Silvestri, R Olcese, O Sacco, A Pistorio, G A Rossi, G Ciprandi
BACKGROUND: Respiratory allergy is characterised by an IgE-mediated reaction. The immune system functions, including IgE production, progressively decline over time with growing up and ageing. Molecular-based allergy diagnostic defines sensitisation profile. This study aimed to evaluate the impact of age on serum allergen-specific IgE to molecular component levels in a large sample of subjects. METHODS: Serum IgE to: rCor a11, rPru p3, nJug r3, rAra h8, rGly m4, rCor a8, nPen m1, nAct d8, Bos d 8, and nGal d2 were assessed by ISAC method...
October 5, 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27683793/sleeve-gastrectomy-in-patients-with-morbid-obesity-and-hiv
#9
José Máximo Costa Pinto, Marianna Gomes Cavalcanti Leite de Lima, Ana Luiza Melo Cavalcanti de Almeida, Marcelo Gonçalves Sousa
Introduction: It is estimated that there are nearly 40 million people with the human immunodeficiency virus (HIV) worldwide. Due to the advent of antiretroviral drugs, it has been observed increasing in obesity and metabolic rates among patients undergoing treatment. Thus, numerous surgical therapies for weight loss are proposed for continuous improvement in health of patients with HIV, being the vertical gastrectomy an option for intact intestinal transit. Objective: To evaluate the applicability of the vertical gastrectomy in patients with morbid obesity and HIV...
2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27664802/influence-of-late-vascular-inflammation-on-long-term-outcomes-among-patients-undergoing-implantation-of-drug-eluting-stents-role-of-c-reactive-protein
#10
Masanori Shiba, Hideki Itaya, Raisuke Iijima, Masato Nakamura
BACKGROUND: Elevation of C-reactive protein (CRP) as a marker of vascular inflammation at a late phase of drug-eluting stent (DES) implantation may predict subsequent major adverse cardiac events (MACE). METHODS AND RESULTS: In 1234 consecutive patients undergoing DES implantation, CRP was measured both before (baseline) and 8 to 12 months after (late phase) stenting, and the relationship between elevation of CRP (>2.0 mg/L) and subsequent MACE (all cause death, nonfatal myocardial infarction, target lesion revascularization, and other additional revascularization) was assessed...
2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27591364/dysfunctional-hdl-in-acute-stroke
#11
Guadalupe Ortiz-Munoz, David Couret, Bertrand Lapergue, Eric Bruckert, Elena Meseguer, Pierre Amarenco, Olivier Meilhac
BACKGROUND AND AIMS: HDL-cholesterol concentration is a reliable negative risk factor for acute cerebral infarction (ACI). Beyond quantitative aspects, our aim was to determine whether lipoprotein profiles and HDL functionality were altered at the acute phase of ischemic stroke. METHODS: Blood was taken from ACI patients within 4.5 h of symptom onset. Lipoproteins were separated by electrophoresis for determination of particle size. HDLs were isolated from plasma of patients (n = 10) and controls (n = 10) by ultracentrifugation...
October 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27587526/the-relationship-between-spinopelvic-measurements-and-patient-reported-outcome-scores-in-patients-with-multiple-myeloma-of-the-spine
#12
H M Yu, K Malhotra, J S Butler, A Patel, M D Sewell, Y Z Li, S Molloy
AIMS: Patients with multiple myeloma (MM) develop deposits in the spine which may lead to vertebral compression fractures (VCFs). Our aim was to establish which spinopelvic parameters are associated with the greatest disability in patients with spinal myeloma and VCFs. PATIENTS AND METHODS: We performed a retrospective cross-sectional review of 148 consecutive patients (87 male, 61 female) with spinal myeloma and analysed correlations between spinopelvic parameters and patient-reported outcome scores...
September 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/27547427/analysis-of-safety-outcomes-for-radial-versus-femoral-access-for-percutaneous-coronary-intervention-from-a-large-clinical-registry
#13
David R Dobies, Kimberly R Barber, Amanda L Cohoon
OBJECTIVE: Using a multisite, contemporary registry of 58 862 percutaneous coronary intervention (PCI) procedures in a national healthcare system, the present study compared radial access with femoral access on safety and efficacy outcomes. METHODS: This is a real-world, large-scale, retrospective study using clinical data from a 137-hopsital System and reported to a multisite clinical registry. All patients undergoing a cardiac catheterisation procedure were included in this database...
2016: Open Heart
https://www.readbyqxmd.com/read/27474340/coupling-of-gel-based-2-de-and-1-de-shotgun-proteomics-approaches-to-dig-deep-into-the-leaf-senescence-proteome-of-glycine-max
#14
Ravi Gupta, Su Ji Lee, Cheol Woo Min, So Wun Kim, Ki-Hun Park, Dong-Won Bae, Byong Won Lee, Ganesh Kumar Agrawal, Randeep Rakwal, Sun Tae Kim
UNLABELLED: Leaf senescence is the last stage of leaf development that re-mobilizes nutrients from the source to sink. Here, we have utilized the soybean as a model system to unravel senescence-associated proteins (SAPs). A comparative proteomics approach was used at two contrasting stages of leaf development, namely mature (R3) and senescent (R7). Selection criteria for these two stages were the contrasting differences in their biochemical parameters - chlorophyll, carotenoids and malondialdehyde contents...
October 4, 2016: Journal of Proteomics
https://www.readbyqxmd.com/read/27385613/a-prospective-study-of-caffeine-and-coffee-intake-and-premenstrual-syndrome
#15
Alexandra C Purdue-Smithe, JoAnn E Manson, Susan E Hankinson, Elizabeth R Bertone-Johnson
BACKGROUND: Clinically significant premenstrual syndrome (PMS) affects 15-20% of premenopausal women, substantially reducing quality of life. Women with PMS often are counseled to minimize caffeine intake, although only limited evidence supports this recommendation. OBJECTIVE: We evaluated the association between total caffeine, coffee, and tea intake and the development of PMS in a case-control study nested within the prospective Nurses' Health Study II. DESIGN: All participants were free from PMS at baseline (1991)...
August 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27222921/structural-and-functional-lung-impairment-in-adult-survivors-of-bronchopulmonary-dysplasia
#16
Steven Caskey, Aisling Gough, Stephen Rowan, Scott Gillespie, Jim Clarke, Marshall Riley, Jacqui Megarry, Paul Nicholls, Chris Patterson, Henry L Halliday, Michael D Shields, Lorcan McGarvey
RATIONALE: As more preterm infants recover from severe bronchopulmonary dysplasia (BPD), it is critical to understand the clinical consequences of this condition on the lung health of adult survivors. OBJECTIVES: To assess structural and functional lung parameters in young adult BPD survivors and preterm and term control subjects. METHODS: Young adult survivors of BPD (mean age, 24 yr) underwent spirometry, lung volume assessment, transfer factor, lung clearance index, and fractional exhaled nitric oxide measurements, together with high-resolution chest computed tomography and cardiopulmonary exercise testing...
August 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27178610/management-of-gallbladder-disease-after-sleeve-gastrectomy-in-a-selected-lebanese-population
#17
Hanaa Dakour Aridi, Serge Sultanem, Houssam Abtar, Bassem Y Safadi, Hayssam Fawal, Ramzi S Alami
BACKGROUND: Patients with morbid obesity are at a higher risk of developing gallstones after bariatric surgery. Studies on the incidence of symptomatic gallstones necessitating cholecystectomy after laparoscopic sleeve gastrectomy (LSG) are limited in the Middle East. OBJECTIVES: This study aims to assess the incidence of cholecystectomy after LSG during a 1-year follow-up and to evaluate potential risk factors and potential prophylactic measures. SETTING: Two university hospitals in Lebanon...
August 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27142422/an-appraisal-of-clinical-practice-guidelines-for-constipation-a-right-attitude-towards-to-guidelines
#18
Hongliang Tian, Chao Ding, Jianfeng Gong, Xiaolong Ge, Lynne V McFarland, Lili Gu, Qiyi Chen, Chunlian Ma, Weiming Zhu, Jieshou Li, Ning Li
BACKGROUND: Clinical practice guidelines (CPGs) are formally developed statements that assist users to provide proper health care for a kind of disease and play a significant contribution in healthcare system. This study report the methodological quality of CPGs on constipation. METHODS: The "Appraisal of Guidelines and Research and Evaluation" (AGREEII) instrument was developed to determine the quality of CPGs. A comprehensive search was developed using five databases and three guideline websites until/up to December, 2015...
2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27050913/revision-surgeries-following-vagus-nerve-stimulator-implantation
#19
Sandi Lam, Yimo Lin, Daniel J Curry, Gaddum D Reddy, Peter C Warnke
The vagus nerve stimulator (VNS) has been shown to provide a safe, albeit costly, treatment for intractable epilepsy. We aimed to analyze the incidence, timing, and clinical/demographic associations of revision surgery post-VNS implantation in epilepsy patients. The Thomson Reuters MarketScan database, containing data from 23-50million individuals, was used. Epilepsy patients receiving VNS implantations from 2003 to 2009 were identified by Current Procedural Terminology and International Classification Of Diseases Ninth Revision codes...
August 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27026518/measures-of-urinary-protein-and-albumin-in-the-prediction-of-progression-of-iga-nephropathy
#20
Yan-Feng Zhao, Li Zhu, Li-Jun Liu, Su-Fang Shi, Ji-Cheng Lv, Hong Zhang
BACKGROUND AND OBJECTIVES: Proteinuria is an independent predictor for IgA nephropathy (IgAN) progression. Urine albumin-to-creatinine ratio (ACR), protein-to-creatinine ratio, and 24-hour urine protein excretion (UPE) are widely used for proteinuria evaluation in clinical practice. Here, we evaluated the association of these measurements with clinical and histologic findings of IgAN and explored which was the best predictor of IgAN prognosis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Patients with IgAN were followed up for ≥12 months, were diagnosed between 2003 and 2012, and had urine samples available (438 patients)...
June 6, 2016: Clinical Journal of the American Society of Nephrology: CJASN
keyword
keyword
22906
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"