Liangyu Lin, Mingyuan Hu, Qing Li, Liming Du, Li Lin, Yueqing Xue, Fanjun Zheng, Fei Wang, Keli Liu, Yu Wang, Jiayin Ye, Xu Jiang, Xuefeng Wang, Jiaqi Wang, Jingjie Zhai, Benming Liu, Hongzhen Xie, Yanqin You, Jinyong Wang, Xiangyin Kong, Dechun Feng, Douglas R Green, Yufang Shi, Ying Wang
The nature of activation signals is essential in determining T cell subset differentiation; however, the features that determine T cell subset preference acquired during intrathymic development remain elusive. Here we show that naive CD4+ T cells generated in the mouse thymic microenvironment lacking Scd1, encoding the enzyme catalyzing oleic acid (OA) production, exhibit enhanced regulatory T (Treg ) cell differentiation and attenuated development of experimental autoimmune encephalomyelitis. Scd1 deletion in K14+ thymic epithelia recapitulated the enhanced Treg cell differentiation phenotype of Scd1-deficient mice...
January 2024: Nature Immunology