keyword
MENU ▼
Read by QxMD icon Read
search

Pamps

keyword
https://www.readbyqxmd.com/read/29337150/heptose-1-7-bisphosphate-directed-tifa-oligomerization-a-novel-pamp-recognizing-signaling-platform-in-control-of-bacterial-infections
#1
EDITORIAL
Suneesh Pachathundikandi, Steffen Backert
No abstract text is available yet for this article.
January 11, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29308881/self-assembling-peptide-nanoscaffold-that-activates-human-mast-cells
#2
Lei Lu, Manoj B Parmar, Marianna Kulka, Peter Kwan, Larry Unsworth
Engineering biomaterials to manipulate the immune response to elicit specific therapeutic outcomes is a burgeoning field of research. Mast cells play a distinct and central role in the innate immune response, and are characterized by their rapid release of a myriad of proinflammatory mediators in response to stimulation. These mediators are central to protective actions such as wound healing, angiogenesis, and host defense against pathogens and animal venoms. Considering that mast cells are widely distributed in tissues that interface with the external environment, and are loaded with large amounts of preformed protective compounds, they are ideal targets for novel immunotherapies...
January 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29277364/identification-of-an-interferon-stimulated-gene-isg15-involved-in-host-immune-defense-against-viral-infections-in-gilthead-seabream-sparus-aurata-l
#3
Daniel Álvarez-Torres, Victoria Gómez-Abellán, Marta Arizcun, Esther García-Rosado, Julia Béjar, María P Sepulcre
Interferons (IFNs) play a key role in the innate immunity of vertebrates against viral infections by inducing hundreds of IFN-stimulated genes (ISGs), such as isg15. Isg15 is an ubiquitin-like protein, which can conjugate cellular and viral proteins in a process called ISGylation, although it can also act as a cytokine-like protein. Gilthead seabream (Sparus aurata L.) is an important asymptomatic carrier of viral haemorrhagic septicaemia virus (VHSV) and nodavirus, representing a threat to other co-cultivated susceptible species...
December 19, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29277308/nrf2-as-regulator-of-innate-immunity-a-molecular-swiss-army-knife
#4
REVIEW
Maurizio Battino, Francesca Giampieri, Francesca Pistollato, Antoni Sureda, Marcos Roberto de Oliveira, Valeria Pittalà, Nikolay Mehterov, Victoria Sarafian, Francesca Fallarino, Seyed Fazel Nabavi, Atanas Georgiev Atanasov, Seyed Mohammad Nabavi
Organisms are constantly exposed to a broad range of pathological and stress-inducing agents, allergens and environmental chemicals that can induce infections, toxicity or other undesirable reactions. Our immune system has evolved over time in order to efficiently respond to these exogenous insults and maintain homeostasis. In particular, the innate immune system acts as primary barrier to prevent the entrance of invasive agents or allergens. This system is comprised of a diversity of cell types that are rapidly activated by recognition of common structures present in many potential pathogens known as pathogen-associated molecular patterns (PAMPs)...
December 22, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/29274514/distribution-of-single-nucleotide-polymorphisms-and-protein-domain-architecture-of-toll-like-receptor-2-in-pahari-cattle-indian-non-descript-indigenous-breed
#5
Verma Subhash, Sodhi Monika, Salwan Richa, Shekhar Chander, Singh Geetanjali, Sharma Mandeep
Distribution of polymorphism in TLR2 gene was studied in Pahari (Indian non-descript indigenous breed) cattle of Himachal Pradesh. The complete sequence of TLR2 gene consisted of 136bp 5'-UTR, 2355bp CDS and 1316bp 3'UTR. The phylogenetic analysis revealed clustering of Indian Zebu with Bos taurus as the nearest neighbour. The nucleotide sequences of TLR2 revealed the occurrence of 19 SNPs including 47% non-synonymous and 53% synonymous SNPs within TLR domain among all bovines. The dS/dN ratio (ω)<1 at polymorphic sites revealed purifying selection and thus, indicating the presence of highly conserved domains...
December 15, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29261777/self-extracellular-rna-acts-in-synergy-with-exogenous-danger-signals-to-promote-inflammation
#6
Frederik Noll, Jonas Behnke, Silke Leiting, Kerstin Troidl, Gustavo Teixeira Alves, Holger Müller-Redetzky, Klaus T Preissner, Silvia Fischer
Self-extracellular RNA (eRNA), released from stressed or injured cells upon various pathological situations such as ischemia-reperfusion-injury, has been shown to act as an alarmin by inducing procoagulatory and proinflammatory responses. In particular, M1-polarization of macrophages by eRNA resulted in the expression and release of a variety of cytokines, including tumor necrosis factor (TNF)-α or interleukin-6 (IL-6). The present study now investigates in which way self-eRNA may influence the response of macrophages towards various Toll-like receptor (TLR)-agonists...
2017: PloS One
https://www.readbyqxmd.com/read/29247998/the-aim2-inflammasome-sensor-of-pathogens-and-cellular-perturbations
#7
REVIEW
Jérôme Lugrin, Fabio Martinon
Recognition of pathogens and altered self must be efficient and highly specific to orchestrate appropriate responses while limiting excessive inflammation and autoimmune reaction to normal self. AIM2 is a member of innate immune sensors that detects the presence of DNA, arguably the most conserved molecules in living organisms. However, AIM2 achieves specificity by detecting altered or mislocalized DNA molecules. It can detect damaged DNA, and the aberrant presence of DNA within the cytosolic compartment such as genomic DNA released into the cytosol upon loss of nuclear envelope integrity...
January 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29238325/probiotic-bacteria-alter-pattern-recognition-receptor-expression-and-cytokine-profile-in-a-human-macrophage-model-challenged-with-candida-albicans-and-lipopolysaccharide
#8
Victor H Matsubara, Karin H Ishikawa, Ellen S Ando-Suguimoto, Bruno Bueno-Silva, Atlas E M Nakamae, Marcia P A Mayer
Probiotics are live microorganisms that confer benefits to the host health. The infection rate of potentially pathogenic organisms such as Candida albicans, the most common agent associated with mucosal candidiasis, can be reduced by probiotics. However, the mechanisms by which the probiotics interfere with the immune system are largely unknown. We evaluated the effect of probiotic bacteria on C. albicans challenged human macrophages. Macrophages were pretreated with lactobacilli alone (Lactobacillus rhamnosus LR32, Lactobacillus casei L324m, or Lactobacillus acidophilus NCFM) or associated with Escherichia coli lipopolysaccharide (LPS), followed by the challenge with C...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29237838/a-single-amino-acid-substitution-within-the-paramyxovirus-sendai-virus-nucleoprotein-is-a-critical-determinant-for-production-of-ifn-beta-inducing-copyback-type-defective-interfering-genomes
#9
Asuka Yoshida, Ryoko Kawabata, Tomoyuki Honda, Kouji Sakai, Yasushi Ami, Takemasa Sakaguchi, Takashi Irie
One of the first defenses against infecting pathogens is the innate immune system activated by cellular recognition of pathogen-associated molecular patterns (PAMPs). Although virus-derived RNA species, especially copyback (cb)-type defective-interfering (DI) genomes, have been shown to serve as real PAMPs, which strongly induce interferon (IFN)-beta during mononegavirus infection, the mechanisms underlying DI generation remain unclear. Here, for the first time, we identified a single amino acid substitution causing production of cbDI genomes by successful isolation of two distinct types of viral clones with cbDI-producing and cbDI-non-producing phenotypes, from the stock Sendai virus (SeV) strain Cantell, which is widely used in a number of studies on anti-viral innate immunity as a representative IFN-beta-inducing virus...
December 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29235493/small-molecules-related-to-adrenomedullin-reduce-tumor-burden-in-a-mouse-model-of-colitis-associated-colon-cancer
#10
Laura Ochoa-Callejero, Josune García-Sanmartín, Sonia Martínez-Herrero, Susana Rubio-Mediavilla, Judit Narro-Íñiguez, Alfredo Martínez
To investigate the contribution of adrenomedullin (AM) and its gene-related peptide, proadrenomedullin N-terminal 20 peptide (PAMP), to the progression and potential treatment of colon cancer we studied the effects of four small molecules (SM) related to AM and PAMP on a mouse model of colon cancer. For each SM, four experimental groups of male mice were used: (i) Control group; (ii) SM group; (iii) DSS group (injected with azoxymethane [AOM] and drank dextran sulfate sodium [DSS]); and (iv) DSS + SM group (treated with AOM, DSS, and the SM)...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29232626/targeted-isolation-and-identification-of-bioactive-compounds-lowering-cholesterol-in-the-crude-extracts-of-crabapples-using-uplc-dad-ms-spe-nmr-based-on-pharmacology-guided-pls-da
#11
Chao Wen, Dongshan Wang, Xing Li, Tao Huang, Cheng Huang, Kaifeng Hu
The anti-hyperlipidemic effects of crude crabapple extracts derived from Malus 'Red jade', Malus hupehensis (Pamp.) Rehd. and Malus prunifolia (Willd.) Borkh. were evaluated on high-fat diet induced obese (HF DIO) mice. The results revealed that some of these extracts could lower serum cholesterol levels in HF DIO mice. The same extracts were also parallelly analyzed by LC-MS in both positive and negative ionization modes. Based on the pharmacological results, 22 LC-MS variables were identified to be correlated with the anti-hyperlipidemic effects using partial least square discriminant analysis (PLS-DA) and independent samples t-test...
December 2, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29226970/a-dominant-interfering-camta3-mutation-compromises-primary-transcriptional-outputs-mediated-by-both-cell-surface-and-intracellular-immune-receptors-in-arabidopsis-thaliana
#12
Florence Jacob, Barbara Kracher, Akira Mine, Carolin Seyfferth, Servane Blanvillain-Baufumé, Jane E Parker, Kenichi Tsuda, Paul Schulze-Lefert, Takaki Maekawa
Pattern recognition receptors (PRRs) and nucleotide-binding domain and leucine-rich repeat (LRR)-containing proteins (NLRs) initiate pattern-triggered immunity (PTI) and effector-triggered immunity (ETI), respectively, each associated with the activation of an overlapping set of defence genes. The regulatory mechanism behind this convergence of PTI- and ETI-mediated defence gene induction remains elusive. We generated transgenic Arabidopsis plants that enable conditional NLR activation without pathogen infection to dissect NLR- and PRR-mediated transcriptional signals...
December 11, 2017: New Phytologist
https://www.readbyqxmd.com/read/29208681/hemitam-a-single-tyrosine-motif-that-packs-a-punch
#13
REVIEW
Björn Bauer, Alexander Steinle
Innate immune cells sense danger through a plethora of germline-encoded receptors that recognize pathogen-associated molecular patterns (PAMPs) or cellular molecules that are exposed only by stressed, infected, malignant, or dead cells. Many of these danger-sensing receptors belong to the C-type lectin-like superfamily (CLSF) and therefore are called C-type lectin-like receptors (CTLRs). Certain activating CTLRs, namely, CLEC-2, Dectin-1, DNGR-1, NKp80, and NKp65, which are encoded by genes that are clustered together in a subregion of the mammalian natural killer gene complex (NKC), use a single copy tyrosine signaling module termed the hemi-immunoreceptor tyrosine-based activation motif (hemITAM)...
December 5, 2017: Science Signaling
https://www.readbyqxmd.com/read/29207132/irf3-signaling-pathway-serves-an-important-role-in-poly-i-c-induced-procollagen-reduction-in-human-skin-fibroblasts
#14
Cheng Yao, Sangbum Han, Chi-Hyun Park, Ye-Ji Kim, Dong Hun Lee, Jin Ho Chung
Pattern recognition receptors (PRRs) are part of the immune system. They can recognize pathogen‑associated molecular patterns (PAMPs). Toll‑like receptors (TLRs) and retinoic acid‑inducible gene 1 (RIG‑1)‑like receptors (RLRs) are 2 types of PRR in the innate immune system. Double‑stranded RNA (dsRNA) can exist as a PAMP, including dsRNA viruses. dsRNA is known as a ligand not only for TLR3 but also for RLRs, including melanoma differentiation‑associated gene 5 and RIG‑1. Collagen is the main structural protein in the extracellular space in the skin...
November 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29203332/toll-like-receptor-tlr-22-a-non-mammalian-tlr-in-asian-seabass-lates-calcarifer-characterisation-ontogeny-and-inductive-expression-upon-exposure-with-bacteria-and-ligands
#15
Anutosh Paria, M Makesh, Aparna Chaudhari, C S Purushothaman, K V Rajendran
Toll-like receptor (TLR) 22 is a non-mammalian TLR found mostly in teleosts and characterized initially as a cell surface surveillance receptor for detecting extracellular long dsRNA. In the current study, the full-length cDNA sequence consisting of 3312 nucleotides encoding for 960 amino acids in Asian seabass (Lates calcarifer) TLR22 (AsTLR22) was identified. From the putative protein sequence, signature TLR domains such as 18 LRR domains, two transmembrane domains, a single LRR_CT domain and an intracellular TIR domain could be predicted...
December 1, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29202128/-toll-free-pathways-for-production-of-type-i-interferons
#16
Ling Wang, Shunbin Ning
Pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) are recognized by different cellular pathogen recognition receptors (PRRs), which are expressed on cell membrane or in the cytoplasm of cells of the innate immune system. Nucleic acids derived from pathogens or from certain cellular conditions represent a large category of PAMPs/DAMPs that trigger production of type I interferons (IFN-I) in addition to pro-inflammatory cytokines, by specifically binding to intracellular Toll-like receptors or cytosolic receptors...
2017: AIMS allergy and immunology
https://www.readbyqxmd.com/read/29196474/inflammasome-activation-and-assembly-at-a-glance
#17
REVIEW
Ankit Malik, Thirumala-Devi Kanneganti
Inflammasomes are multimeric protein complexes that typically comprise a sensor, an adaptor and the zymogen procaspase-1. An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs). The inflammasome platform leads to activation of caspase-1 through proximity-induced self-cleavage, which further induces maturation of interleukins 1β and 18 (IL-1β and IL-18) through proteolytic cleavage of pro-IL-1β and pro-IL-18. Activated caspase-1 also cleaves gasdermin D, which leads to a particular form of cell death called pyroptosis...
December 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29193992/tlrs-nlrs-shaping-the-landscape-of-host-immunity
#18
Komal Dolasia, Manoj K Bisht, Gourango Pradhan, Atul Udgata, Sangita Mukhopadhyay
Innate immune system provides the first line of defense against pathogenic organisms. It has a varied and large collection of molecules known as pattern recognition receptors (PRRs) which can tackle the pathogens promptly and effectively. Toll-like receptors (TLRs) and NOD-like receptors (NLRs) are members of the PRR family that recognize pathogen associated molecular patterns (PAMPs) and play pivotal roles to mediate defense against infections from bacteria, fungi, virus and various other pathogens. In this review, we discuss the critical roles of TLRs and NLRs in the regulation of host immune-effector functions such as cytokine production, phagosome-lysosome fusion, inflammasome activation, autophagy, antigen presentation, and B and T cell immune responses that are known to be essential for mounting a protective immune response against the pathogens...
December 1, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/29187812/adrenomedullin-contributes-to-age-related-memory-loss-in-mice-and-is-elevated-in-aging-human-brains
#19
Ignacio M Larrayoz, Hilda Ferrero, Eva Martisova, Francisco J Gil-Bea, María J Ramírez, Alfredo Martínez
Memory decline is common in elderly individuals and is the hallmark of Alzheimer's disease (AD). Memory failure follows the loss of synaptic contacts in the cerebral cortex and hippocampus, caused in part by cytoskeleton disruption. Adrenomedullin (AM) and its gene-related peptide, proadrenomedullin N-terminal 20 peptide (PAMP), are microtubule-associated proteins (MAP) whose expression has been identified as a potential biomarker for predicting progression from predementia to clinical AD. Here we analyze the connection between AM levels and memory preservation...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29187337/prr-signaling-during-in-vitro-macrophage-differentiation-from-progenitors-modulates-their-subsequent-response-to-inflammatory-stimuli
#20
Alba Martínez, Cristina Bono, Javier Megías, Alberto Yáñez, Daniel Gozalbo, M Luisa Gil
Toll-like receptor (TLR) agonists drive hematopoietic stem and progenitor cells (HSPCs) to differentiate along the myeloid lineage in vitro and also in vivo following infection. In this study, we used an in vitro model of HSPC differentiation to investigate the functional consequences (cytokine production) that exposing HSPCs to various pathogen-associated molecular patterns (PAMPs) and Candida albicans cells have on the subsequently derived macrophages. Mouse HSPCs (Lin- cells) were cultured with GM-CSF to induce macrophage differentiation in the presence or absence of the following pattern recognition receptor (PRR) agonists: Pam3CSK4 (TLR2 ligand), LPS (TLR4 ligand), depleted zymosan (which only activates Dectin-1), or inactivated C...
September 1, 2017: European Cytokine Network
keyword
keyword
22897
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"