keyword
MENU ▼
Read by QxMD icon Read
search

Pamps

keyword
https://www.readbyqxmd.com/read/28532476/effects-of-osteochondral-defect-size-on-cartilage-regeneration-using-a-double-network-hydrogel
#1
Kotaro Higa, Nobuto Kitamura, Keiko Goto, Takayuki Kurokawa, Jian Ping Gong, Fuminori Kanaya, Kazunori Yasuda
BACKGROUND: There has been increased interest in one-step cell-free procedures to avoid the problems related to cell manipulation and its inherent disadvantages. We have studied the chondrogenic induction ability of a PAMPS/PDMAAm double-network (DN) gel and found it to induce chondrogenesis in animal osteochondral defect models. The purpose of this study was to investigate whether the healing process and the degree of cartilage regeneration induced by the cell-free method using DN gel are influenced by the size of osteochondral defects...
May 22, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28526573/transcriptomic-variation-of-locally-infected-skin-of-epinephelus-coioides-reveals-the-mucosal-immune-mechanism-against-cryptocaryon-irritans
#2
Yazhou Hu, Anxing Li, Yang Xu, Biao Jiang, Geling Lu, Xiaochun Luo
Fish skin is the largest immunologically active mucosal organ, providing first-line defense against external pathogens. However, the skin-associated immune mechanisms of fish are still unclear. Cryptocaryon irritans is an obligate ectoparasitic ciliated protozoan that infects almost all marine fish, and is believed to be an excellent pathogen model to study fish mucosal immunity. In this study, a de novo transcriptome assembly of Epinephelus coioides skin post C. irritans tail-infection was performed for the first time using the Illumina HiSeq™ 2500 system...
May 16, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28525309/from-chaos-to-harmony-responses-and-signaling-upon-microbial-pattern-recognition
#3
Xiao Yu, Baomin Feng, Ping He, Libo Shan
Pathogen- or microbe-associated molecular patterns (PAMPs/MAMPs) are detected as nonself by host pattern recognition receptors (PRRs) and activate pattern-triggered immunity (PTI). Microbial invasions often trigger the production of host-derived endogenous signals referred to as dangeror damage-associated molecular patterns (DAMPs), which are also perceived by PRRs to modulate PTI responses. Collectively, PTI contributes to host defense against infections by a broad range of pathogens. Remarkable progress has been made toward demonstrating the cellular and physiological responses upon pattern recognition, elucidating the molecular, biochemical, and genetic mechanisms of PRR activation as well as dissecting the complex signaling networks that orchestrate PTI responses...
May 19, 2017: Annual Review of Phytopathology
https://www.readbyqxmd.com/read/28507137/arabidopsis-glycosylphosphatidylinositol-anchored-protein-llg1-associates-with-and-modulates-fls2-to-regulate-innate-immunity
#4
Qiujing Shen, Gildas Bourdais, Huairong Pan, Silke Robatzek, Dingzhong Tang
Plants detect and respond to pathogen invasion with membrane-localized pattern recognition receptors (PRRs), which recognize pathogen-associated molecular patterns (PAMPs) and activate downstream immune responses. Here we report that Arabidopsis thaliana LORELEI-LIKE GPI-ANCHORED PROTEIN 1 (LLG1), a coreceptor of the receptor-like kinase FERONIA, regulates PRR signaling. In a forward genetic screen for suppressors of enhanced disease resistance 1 (edr1), we identified the point mutation llg1-3, which suppresses edr1 disease resistance but does not affect plant growth and development...
May 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28504091/toll-like-receptor-4-an-important-molecule-in-recognition-and-induction-of-appropriate-immune-responses-against-chlamydia-infection
#5
REVIEW
Reza Nosratababadi, Vahid Bagheri, Mohammad Zare-Bidaki, Hamid Hakimi, Nahid Zainodini, Mohammad Kazemi Arababadi
Chlamydia species are obligate intracellular pathogens causing different infectious diseases particularly asymptomatic genital infections and are also responsible for a wide range of complications. Previous studies showed that there are different immune responses to Chlamydia species and their infections are limited to some cases. Moreover, Chlamydia species are able to alter immune responses through modulating the expression of some immune system related molecules including cytokines. Toll like receptors (TLRs) belonge to pathogen recognition receptors (PRRs) and play vital roles in recognition of microbes and stimulation of appropriate immune responses...
April 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28501024/sensing-of-molecular-patterns-through-cell-surface-immune-receptors
#6
REVIEW
Stefanie Ranf
In plants, sensing of Pathogen/Microbe-Associated Molecular Patterns (PAMPs/MAMPs) and host-derived Damage-Associated Molecular Patterns (DAMPs) by host cell surface Pattern Recognition Receptors (PRRs) activates Pattern-Triggered Immunity (PTI). The identification of an increasing number of immunogenic patterns and PRRs illustrates that PTI is a universal defence mechanism against pathogens, pests, and parasitic plants, and that evolutionary selective pressure drives diversification of molecular patterns and diversity of PRRs...
May 10, 2017: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/28498555/trauma-related-pain-reexperiencing-symptoms-and-treatment-of-posttraumatic-stress-disorder-a-longitudinal-study-of-veterans
#7
Gregory Bartoszek, Susan M Hannan, Janina Kamm, Barbara Pamp, Kelly P Maieritsch
Research has demonstrated a strong positive association between posttraumatic stress disorder (PTSD) symptoms and physical pain. However, few studies have explored the impact of pain problems on the symptoms and treatment of PTSD, and results remain inconsistent. This longitudinal study examined whether trauma-related and trauma-unrelated pain differentially and uniquely predicted reexperiencing symptoms. We also examined whether levels of reexperiencing symptoms mediated the relationship between pain intensity and posttreatment symptoms of avoidance, numbing, and hyperarousal (ANH)...
May 12, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/28495615/a-novel-function-of-tlr4-in-mediating-the-immunomodulatory-effect-of-benzanthrone-an-environmental-pollutant
#8
Prachi Tewari, Payal Mandal, Ruchi Roy, Somya Asthana, Premendra D Dwivedi, Mukul Das, Anurag Tripathi
Our prior studies have reported that Benzanthrone (BA) manifests inflammatory responses in the spleen of Balb/c mice. The present investigation was carried out to study the impact of BA on macrophages, which are the primary scavenger cells in the body that act as a connecting link between innate and adaptive immunity. Parenteral administration of BA (daily for one week) to mice resulted in enhanced levels of nitric oxide (NO) and overexpression of inflammatory markers (COX-2, MMP-9 and PGE-2) in macrophages; however the level of MHC class-I and MHC class-II receptors were down regulated...
May 8, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28494589/complexes-covered-with-phosphorylcholine-groups-prepared-by-mixing-anionic-diblock-copolymers-and-cationic-surfactants
#9
Keita Nakai, Kazuhiko Ishihara, Shin-Ichi Yusa
Anionic diblock copolymers (PmAn) composed of biocompatible polybetaine, poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC), and anionic poly(sodium 2-(acrylamido)-2-methylpropane sulfonate) (PAMPS) were synthesized via reversible addition-fragmentation chain transfer (RAFT) radical polymerization. Two types of diblock copolymers (P24A217 and P100A99) were prepared with different compositions. The PmAn/CTAB complexes were formed by a stoichiometrically charge-neutralized mixture of anionic PmAn and cationic cetyltrimethylammonium bromide (CTAB) micelles in water...
May 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28490801/dendritic-cells-provide-a-therapeutic-target-for-synthetic-small-molecule-analogues-of-the-parasitic-worm-product-es-62
#10
Felicity E Lumb, James Doonan, Kara S Bell, Miguel A Pineda, Marlene Corbet, Colin J Suckling, Margaret M Harnett, William Harnett
ES-62, a glycoprotein secreted by the parasitic filarial nematode Acanthocheilonema viteae, subverts host immune responses towards anti-inflammatory phenotypes by virtue of covalently attached phosphorylcholine (PC). The PC dictates that ES-62 exhibits protection in murine models of inflammatory disease and hence a library of drug-like PC-based small molecule analogues (SMAs) was synthesised. Four sulfone-containing SMAs termed 11a, 11e, 11i and 12b were found to reduce mouse bone marrow-derived dendritic cell (DC) pathogen-associated molecular pattern (PAMP)-induced pro-inflammatory cytokine production, inhibit NF-κB p65 activation, and suppress LPS-induced up-regulation of CD40 and CD86...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28484129/expression-of-ayu-antimicrobial-peptide-genes-after-lps-stimulation
#11
Rehab Marray Nsrelden, Hiroyuki Horiuchi, Shuichi Furusawa
Plecoglossus altivelis (ayu) is one of the most important fish species in the Japanese islands and in internal fish hatcheries. Living in open aquatic environments exposes fish to many pathogens. Therefore, they require rapid and strong immune defenses. We investigated in vivo the direct association between the ayu innate immune response, represented by the relative transcription of genes encoding the cathelicidin and hepcidin antimicrobial peptides, and lipopolysaccharide (LPS), a conventional pathogen-associated molecular patterns (PAMPs) of Gram-negative bacteria...
May 7, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28482045/using-gcamp3-to-study-ca2-signaling-in-nicotiana-species
#12
Thomas A DeFalco, Masatsugu Toyota, Van Phan, Purva Karia, Wolfgang Moeder, Simon Gilroy, Keiko Yoshioka
Ca2+ signaling is a central component of plant biology; however, direct analysis of in vivo Ca2+ levels is experimentally challenging. In recent years the use of genetically-encoded Ca2+ indicators have revolutionized the study of plant Ca2+ signaling, although such studies have been largely restricted to the model plant Arabidopsis. We have developed stable transgenic Nicotiana benthamiana and Nicotiana tabacum lines expressing the single-wavelength fluorescent Ca2+ indicator, GCaMP3. Ca2+ levels in these plants can be imaged in situ using fluorescence microscopy, and these plants can be used to both qualitatively and semi-quantitatively evaluate Ca2+ signals in response to a broad array of abiotic or biotic stimuli, such as cold-shock or pathogen-associated molecular patterns (PAMPs)...
May 8, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28473804/the-complement-system-a-prey-of-trypanosoma-cruzi
#13
REVIEW
Kárita C F Lidani, Lorena Bavia, Altair R Ambrosio, Iara J de Messias-Reason
Trypanosoma cruzi is a protozoan parasite known to cause Chagas disease (CD), a neglected sickness that affects around 6-8 million people worldwide. Originally, CD was mainly found in Latin America but more recently, it has been spread to countries in North America, Asia, and Europe due the international migration from endemic areas. Thus, at present CD represents an important concern of global public health. Most of individuals that are infected by T. cruzi may remain in asymptomatic form all lifelong, but up to 40% of them will develop cardiomyopathy, digestive mega syndromes, or both...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28472619/toll-like-receptor-4-and-hepatocellular-carcinoma-a-systematic-review
#14
REVIEW
Zahra Sepehri, Zohre Kiani, Farhad Kohan, Seyed Moayed Alavian, Saeid Ghavami
INTRODUCTION: Toll like receptor 4 (TLR4) is an extracellular pathogen recognition receptor (PRR) which recognizes a wide range of pathogens and damage associated molecular patterns (PAMPs and DAMPs). It can activate intracellular signaling and consequently transcription factors which participate in transcription from either immune related or malignancy genes. Thus, it has been hypothesized that TLR4 may be a cause of hepatocellular carcinoma (HCC). This article has reviewed the roles of TLR4 in the pathogenesis of HCC...
May 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/28466394/involvement-of-c-abl-kinase-in-microglial-activation-of-nlrp3-inflammasome-and-impairment-in-autolysosomal-system
#15
Vivek Lawana, Neeraj Singh, Souvarish Sarkar, Adhithiya Charli, Huajun Jin, Vellareddy Anantharam, Anumantha G Kanthasamy, Arthi Kanthasamy
A growing body of evidence suggests that excessive microglial activation and pesticide exposure may be linked to the etiology of PD; however, the mechanisms involved remain elusive. Emerging evidence indicates that intracellular inflammasome complex namely NLRP3 complex is involved in the recognition and execution of host inflammatory response. Thus, in the present study, we investigated the hypothesis that NLRP3 inflammasome activation is linked to rotenone (ROT)-induced microglial activation which is dependent upon a priming stimulus by a pathogen-associated molecular pattern (PAMP) or damage associated molecular pattern (DAMP), respectively...
May 2, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/28460048/role-of-pattern-recognition-receptors-in-the-modulation-of-antimicrobial-peptide-expression-in-the-corneal-epithelial-innate-response-to-f-solani
#16
Satya Sree Kolar, Hasna Baidouri, Alison M McDermott
Purpose: Fusarium solani (F. solani) keratitis is a potentially sight-threatening fungal infection of the cornea. Antimicrobial peptides (AMPs), such as human β-defensins (hBDs) and cathelicidins, essential components of the immune system, likely have a protective role against F. solani keratitis. We examined the role of pattern recognition receptors (PRRs), Dectin-1, and TLR2 in F. solani-induced modulation of AMP expression in vitro. Methods: Human corneal epithelial cells (HCECs) were exposed to heat-inactivated F...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28459101/innate-immunity-and-chronic-rhinosinusitis-what-we-have-learned-from-animal-models
#17
Nyall R London, Andrew P Lane
OBJECTIVE: Chronic rhinosinusitis (CRS) is a heterogeneous and multifactorial disease characterized by dysregulated inflammation. Abnormalities in innate immune function including sinonasal epithelial cell barrier function, mucociliary clearance, response to pathogen-associated molecular patterns (PAMPs) via pattern recognition receptors (PRRs), and the contribution of innate immune cells will be highlighted in this review. DATA SOURCES: PubMed literature review...
June 2016: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28453304/mold-allergy-is-it-real-and-what-do-we-do-about-it
#18
Amanda Rudert, Jay Portnoy
fungi produce substances that contain pathogen-associated molecular patterns (pamps) and damage-associated molecular patterns (damps) which bind to pattern recognition receptors, stimulating innate immune responses in humans. they also produce allergens that induce production of specific ige. Areas covered: In this review we cover both innate and adaptive immune responses to fungi. Some fungal products can activate both innate and adaptive responses and in doing so, cause an intense and complex health effects...
May 17, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28446917/shoot-the-message-not-the-messenger-combating-pathogenic-virulence-in-plants-by-inhibiting-quorum-sensing-mediated-signaling-molecules
#19
REVIEW
Ganesh Alagarasan, Kumar S Aswathy
Immunity, virulence, biofilm formation, and survival in the host environment are regulated by the versatile nature of density dependent microbial cell signaling, also called quorum sensing (QS). The QS molecules can associate with host plant tissues and, at times, cause a change in its gene expression at the downstream level through inter-kingdom cross talking. Progress in controlling QS through fungicide/bactericide in pathogenic microscopic organisms has lead to a rise of antibiotic resistance pathogens. Here, we review the application of selective quorum quenching (QQ) endophytes to control phytopathogens that are shared by most, if not all, terrestrial plant species as well as aquatic plants...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28443393/cd14-gene-silencing-alters-the-microrna-expression-profile-of-raw264-7-cells-stimulated-by-brucella-melitensis-infection
#20
Hui Rong, Hanwei Jiao, Yongchang Hao, Feng Pang, Guohua Li, Dongmei Peng, Yaying Li, Yuanzhi Wang, Hui Zhang, Quanshui Fan, Fengyang Wang, Chuangfu Chen, Li Du
Innate recognition of Brucella spp. is a key step in the activation of inflammation. CD14 binds PAMPs and is involved in LPS-induced pro-inflammatory cytokine release. Previously we showed that knock down of CD14 in RAW264.7 macrophages disrupted Brucella-host interactions. However, its effect on the macrophage microRNA (miRNA) expression profile, especially after stimulation by Brucella infection, is still unclear. To identify miRNAs involved in the macrophage response to Brucella infection, we performed miRNA expression profiling of CD14 knock-down RAW264...
January 1, 2017: Innate Immunity
keyword
keyword
22897
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"