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https://www.readbyqxmd.com/read/28640974/resistance-to-powdery-mildew8-1-boosts-pattern-triggered-immunity-against-multiple-pathogens-in-arabidopsis-and-rice
#1
Yan Li, Yong Zhang, Qing-Xia Wang, Ting-Ting Wang, Xiao-Long Cao, Zhi-Xue Zhao, Sheng-Li Zhao, Yong-Ju Xu, Zhi-Yuan Xiao, Jin-Lu Li, Jing Fan, Hui Yang, Fu Huang, Shunyuan Xiao, Wen-Ming Wang
The Arabidopsis gene RESISTANCE TO POWDERY MILDEW8.1 (RPW8.1) confers resistance to virulent fungal and oomycete pathogens that cause powdery mildew and downy mildew, respectively. However, the underlying mechanism remains unclear. Here, we show that ectopic expression of RPW8.1 boosts pattern-triggered immunity (PTI) resulting in enhanced resistance against different pathogens in both Arabidopsis and rice. In Arabidopsis, transcriptome analysis revealed that ectopic expression of RPW8.1-YFP constitutively up-regulates expression of many pathogen-associated molecular pattern-(PAMP-) inducible genes...
June 22, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28637377/the-candidatus-liberibacter-host-interface-insights-into-pathogenesis-mechanisms-and-disease-control
#2
Nian Wang, Elizabeth A Pierson, João Carlos Setubal, Jin Xu, Julien G Levy, Yunzeng Zhang, Jinyun Li, Luiz Thiberio Rangel, Joaquim Martins
"Candidatus Liberibacter" species are associated with economically devastating diseases of citrus, potato, and many other crops. The importance of these diseases as well as the proliferation of new diseases on a wider host range is likely to increase as the insects vectoring the "Ca. Liberibacter" species expand their territories worldwide. Here, we review the progress on understanding pathogenesis mechanisms of "Ca. Liberibacter" species and the control approaches for diseases they cause. We discuss the Liberibacter virulence traits, including secretion systems, putative effectors, and lipopolysaccharides (LPSs), as well as other important traits likely to contribute to disease development, e...
June 21, 2017: Annual Review of Phytopathology
https://www.readbyqxmd.com/read/28635582/protective-effects-of-ethanol-extracts-of-artemisia-asiatica-nakai-ex-pamp-on-ageing-induced-deterioration-in-mouse-oocyte-quality
#3
Hyuk-Joon Jeon, Seung Yeop You, Dong Hyun Kim, Hong Bae Jeon, Jeong Su Oh
Following ovulation, oocytes undergo a time-dependent deterioration in quality referred to as post-ovulatory ageing. Although various factors influence the post-ovulatory ageing of oocytes, oxidative stress is a key factor involved in deterioration of oocyte quality. Artemisia asiatica Nakai ex Pamp. has been widely used in East Asia as a food ingredient and traditional medicine for the treatment of inflammation, cancer, and microbial infections. Recent studies have shown that A. asiatica exhibits antioxidative effects...
June 21, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28630093/dendritic-cell-sensing-of-hydrophobic-di-and-triacylated-lipopeptides-self-assembled-within-synthetic-virus-like-particles
#4
Rajni Sharma, Arin Ghasparian, John A Robinson, Kenneth C McCullough
Dendritic cells (DCs) play critical roles in developing immune defenses. One important aspect is interaction with pathogen-associated molecular patterns (PAMPs)/danger-associated molecular patterns, including di- and triacylated lipopeptides. Isolated or synthetic lipopeptides are potent vaccine adjuvants, interacting with cell surface TLR2 heterodimers. In contrast, deep embedment within bacteria cell walls would impair lipopeptide interaction with cell surface TLR2, requiring degradation for PAMP recognition...
June 19, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28623733/a-novel-immune-related-gene-hdd1-of-silkworm-bombyx-mori-is-involved-in-bacterial-response
#5
Kui Zhang, Guangzhao Pan, Yuzu Zhao, Xiangwei Hao, Chongyang Li, Li Shen, Rui Zhang, Jingjing Su, Hongjuan Cui
Insects have evolved an effective immune system to respond to various challenges. In this study, a novel immune-related gene, called BmHDD1, was first charactered in silkworm, Bombyx mori. BmHDD1 contained an ORF of 837bp and encoding a deduced protein of 278 amino acids. BmHDD1 was specifically expressed in hemocytes, and highly expressed at the molting and metamorphosis stages under normal physiological conditions. Our results suggested that BmHDD1 was mainly generated by hemocytes and secreted into hemolymph...
June 14, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28617654/function-discovery-and-exploitation-of-plant-pattern-recognition-receptors-for-broad-spectrum-disease-resistance
#6
Freddy Boutrot, Cyril Zipfel
Plants are constantly exposed to would-be pathogens and pests, and thus have a sophisticated immune system to ward off these threats, which otherwise can have devastating ecological and economic consequences on ecosystems and agriculture. Plants employ receptor kinases (RKs) and receptor-like proteins (RLPs) as pattern recognition receptors (PRRs) to monitor their apoplastic environment and detect non-self and damaged-self patterns as signs of potential danger. Plant PRRs contribute to both basal and non-host resistances, and treatment with pathogen-/microbe-associated molecular patterns (PAMPs/MAMPs) or damage-associated molecular patterns (DAMPs) recognized by plant PRRs induces both local and systemic immunity...
June 15, 2017: Annual Review of Phytopathology
https://www.readbyqxmd.com/read/28605397/pamps-prrs-effectors-and-r-genes-associated-with-citrus-pathogen-interactions
#7
Ronaldo J D Dalio, Diogo M Magalhães, Carolina M Rodrigues, Gabriella D Arena, Tiago S Oliveira, Reinaldo R Souza-Neto, Simone C Picchi, Paula M M Martins, Paulo J C Santos, Heros J Maximo, Inaiara S Pacheco, Alessandra A De Souza, Marcos A Machado
No abstract text is available yet for this article.
June 12, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28602683/a-c-type-lectin-nattectin-like-protein-cantc-in-qihe-crucian-carp-carassius-auratus-binding-ability-with-lps-pgn-and-various-bacteria-and-agglutinating-activity-against-bacteria
#8
Li Wang, Jie Zhang, Xianghui Kong, Xianliang Zhao, Chao Pei, Li Li
C-type lectins (CTLs), as the members of pattern-recognition receptors (PRRs), play the significant roles in innate immunity through binding with pathogen-associated molecular patterns (PAMPs) on the surface of microbe. In the present study, a novel CTL, Nattectin-like protein (named as CaNTC), was investigated in Qihe crucian carp Carassius auratus. The full-length cDNA of CaNTC was composed of 776 bp, with a 152 bp 5'-untranslated region (UTR), a 492 bp ORF encoding a 163-aa protein, and a 132 bp 3'-UTR with a polyadenylation signal sequence AATAAA and a poly(A) tail...
June 6, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28599247/inflammasomes-the-cardinal-pathology-mediators-are-activated-by-pathogens-allergens-and-mutagens-a-critical-review-with-focus-on-nlrp3
#9
REVIEW
Seema Patel
Inflammation is a pivotal defense system of body. Unfortunately, when homeostasis falters, the same inflammatory mechanism acts as a double-edged sword, and turns offensive, paving the path for a broad array of pathologies. A multi-protein complex termed as inflammasome perceives the PAMPs (pathogen associated molecular patterns) and DAMPs (danger associated molecular patterns), executing immune responses. This activation predominantly encompasses the elaboration of effector cytokines IL-1β, IL-18, and the cysteine proteases (caspase 1 and 11)...
June 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28595359/intracellular-ca2-is-important-for-flagellin-triggered-defense-in-arabidopsis-and-involves-inositol-polyphosphate-signaling
#10
Yi Ma, Yichen Zhao, Gerald A Berkowitz
Cytosolic Ca2+ increase is a crucial and early step of plant immunity evoked by pathogen-associated molecular patterns (PAMPs) such as flagellin (flg). Components responsible for this increase are still not uncovered, although current models of plant immune signaling portray extracellular Ca2+ influx as paramount to flg activation of defense pathways. Work presented here provides new insights into cytosolic Ca2+ increase associated with flg-induced defense responses. We show that extracellular Ca2+ contributes more to immune responses evoked by plant elicitor peptide (Pep3) than that evoked by flg, indicating an intracellular Ca2+ source responsible for immune responses evoked by flg...
June 8, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28588486/potential-of-il-1-il-18-and-inflammasome-inhibition-for-the-treatment-of-inflammatory-skin-diseases
#11
REVIEW
Gabriele Fenini, Emmanuel Contassot, Lars E French
In 2002, intracellular protein complexes known as the inflammasomes were discovered and were shown to have a crucial role in the sensing of intracellular pathogen- and danger-associated molecular patterns (PAMPs and DAMPs). Activation of the inflammasomes results in the processing and subsequent secretion of the pro-inflammatory cytokines IL-1β and IL-18. Several autoinflammatory disorders such as cryopyrin-associated periodic syndromes and Familial Mediterranean Fever have been associated with mutations of genes encoding inflammasome components...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28588308/a-four-biomarker-blood-signature-discriminates-systemic-inflammation-due-to-viral-infection-versus-other-etiologies
#12
D L Sampson, B A Fox, T D Yager, S Bhide, S Cermelli, L C McHugh, T A Seldon, R A Brandon, E Sullivan, J J Zimmerman, M Noursadeghi, R B Brandon
The innate immune system of humans and other mammals responds to pathogen-associated molecular patterns (PAMPs) that are conserved across broad classes of infectious agents such as bacteria and viruses. We hypothesized that a blood-based transcriptional signature could be discovered indicating a host systemic response to viral infection. Previous work identified host transcriptional signatures to individual viruses including influenza, respiratory syncytial virus and dengue, but the generality of these signatures across all viral infection types has not been established...
June 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28585627/guided-protein-cell-patterning-on-superhydrophilic-polymer-brushes-functionalized-with-mussel-inspired-polydopamine-coatings
#13
Jianwen Hou, Tao Liu, Runhai Chen, Jingchuan Liu, Jiayue Chen, Chunyu Zhao, Ligang Yin, Chunming Li, Xiaodong Xu, Qiang Shi, Jinghua Yin
A simple approach for preparing bicomponent polymer patterns was developed by coating polydopamine (PDA) on superhydrophilic poly(2-acryl-amido-2-methylpropane sulfonic acid) (PAMPS) brushes. Well-defined and versatile arrays of proteins and cells were achieved without harm to proteins and cells.
June 6, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28579520/live-imaging-of-the-innate-immune-response-in-neonates-reveals-differential-tlr2-dependent-activation-patterns-in-sterile-inflammation-and-infection
#14
Melanie Lalancette-Hébert, Joel Faustino, Sai Sampath Thammisetty, Sophorn Chip, Zinaida S Vexler, Jasna Kriz
Activation of microglial cells in response to brain injury and/or immune stimuli is associated with a marked induction of Toll-like receptors (TLRs). While in adult brain, the contribution of individual TLRs, including TLR2, in pathophysiological cascades has been well established, their role and spatial and temporal induction patterns in immature brain are far less understood. To examine whether infectious stimuli and sterile inflammatory stimuli trigger distinct TLR2-mediated innate immune responses, we used three models in postnatal day 9 (P9) mice, a model of infection induced by systemic endotoxin injection and two models of sterile inflammation, intra-cortical IL-1β injection and transient middle cerebral artery occlusion (tMCAO)...
June 1, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28569730/inflammasomes-and-il-1-biology-in-the-pathogenesis-of-allograft-dysfunction
#15
REVIEW
S Samuel Weigt, Vyacheslav Palchevskiy, John A Belperio
Inflammasomes are high-molecular-weight cytosolic complexes that mediate the activation of caspases. There are many inflammasomes, and each is influenced by a unique pattern-recognition receptor response. Two signals are typically involved in the inflammasome pathways. Signal one involves recognition of pathogen-associated molecular patterns (PAMPs), such as LPS or other colonizing/invading microbes, that interact with TLRs, which induce the downstream production of pro-IL-1β. This is followed by signal two, which involves recognition of PAMPs or damage-associated molecular patterns (DAMPs), such as uric acid or ATP, via NLRP3, which leads to caspase-1-dependent cleavage of pro-IL-1β to active IL-1β and pyroptosis...
June 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28569318/thermosensitive-polymer-controlled-morphogenesis-and-phase-discrimination-of-calcium-carbonate
#16
Jun Jiang, Klaus Tauer, Yun-Hao Qiu, Ya-Xu Zhong, Min-Rui Gao, Markus Antonietti, Shu-Hong Yu
Homogeneous aragonite flowers with controlled surface structures can be synthesized by using a thermosensitive polymer, i.e. poly (ethylene glycol)-poly(N-isopropyl acrylamide)-poly(acrylamido methyl propane sulfonate) (PEG-PNIPAM-PAMPS), as a crystal growth modifier in the mineralization of calcium carbonate.
June 1, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28566659/effects-of-natural-and-chemically-defined-nutrients-on-candida-albicans-water-soluble-fraction-caws-vasculitis-in-mice
#17
Wataru Sato, Ken-Ichi Ishibashi, Daisuke Yamanaka, Yoshiyuki Adachi, Naohito Ohno
Kawasaki disease (KD) is an inflammatory disease that was identified by Professor Tomisaku Kawasaki in 1961. Candida albicans-derived substances, such as C. albicans water-soluble fraction (CAWS) , induce coronary arteritis similar to KD in mice. CAWS functions as a pathogen-associated molecular pattern (PAMP) by acting as a ligand for dectin-2. A gut-associated immunological system has developed specifically to segregate advantageous and detrimental stimuli, and the microbial flora has been found to markedly affect the development and severity of diseases...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28555697/double-network-hydrogels-with-highly-enhanced-toughness-based-on-a-modified-first-network
#18
Jun Liang, Guorong Shan, Pengju Pan
A novel double network (DN) hydrogel with highly enhanced toughness has been prepared using reversible addition-fragmentation transfer (RAFT)-modified poly(2-acrylamide-2-methylpropane sulfonic acid) (PAMPS) as the first network, and polyacrylamide (PAM) as the second network. The mechanical properties of the first-network-modified PAMPS/PAM DN hydrogels have been studied and the new DN hydrogel shows remarkably high fracture energy (3.3 MJ m(-3)) in tensile deformation, which is nearly 9 times larger than that of the unmodified PAMPS/PAM DN hydrogel...
June 7, 2017: Soft Matter
https://www.readbyqxmd.com/read/28555019/mutual-regulation-of-nod2-and-rig-i-in-zebrafish-provides-insights-into-the-coordination-between-innate-antibacterial-and-antiviral-signaling-pathways
#19
Li Nie, Xiao-Xiao Xu, Li-Xin Xiang, Jian-Zhong Shao, Jiong Chen
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) and retinoic acid-inducible gene I (RIG-I) are two important cytosolic pattern recognition receptors (PRRs) in the recognition of pathogen-associated molecular patterns (PAMPs), initiating innate antibacterial and antiviral signaling pathways. However, the relationship between these PRRs, especially in teleost fish models, is rarely reported. In this article, we describe the mutual regulation of zebrafish NOD2 (DrNOD2) and RIG-I (DrRIG-I) in innate immune responses...
May 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28554690/functions-of-two-malus-hupehensis-pamp-rehd-ytps-mhytp1-and-mhytp2-in-biotic-and-abiotic-stress-responses
#20
Na Wang, Tianli Guo, Xun Sun, Xin Jia, Ping Wang, Yun Shao, Bowen Liang, Xiaoqing Gong, Fengwang Ma
RNA binding proteins play important roles in plant responses to biotic and abiotic stresses. The YT521-B homology (YTH) domain-containing RNA binding protein (YTP) was first found in Rattus norvegicus and is related to oxygen-deficient stress. The Malus YTP gene family has 15 members. Results from their functional analysis will help researchers improve stress tolerance and fruit quality in apple. We cloned two homologous YTP family members in M. hupehensis - MhYTP1 and MhYTP2 - and identified their promoter regions that contain many cis-elements related to biotic and abiotic stresses...
August 2017: Plant Science: An International Journal of Experimental Plant Biology
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