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https://www.readbyqxmd.com/read/28747793/bone-matrix-components-activate-the-nlrp3-inflammasome-and-promote-osteoclast-differentiation
#1
Yael Alippe, Chun Wang, Biancamaria Ricci, Jianqiu Xiao, Chao Qu, Wei Zou, Deborah V Novack, Yousef Abu-Amer, Roberto Civitelli, Gabriel Mbalaviele
The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific activation of the inflammasomes, we tested the hypothesis that bone matrix components function as DAMPs for the NLRP3 inflammasome and regulate osteoclast differentiation. Indeed, bone particles cause exuberant osteoclastogenesis in the presence of RANKL, a response that correlates with NLRP3 abundance and the state of inflammasome activation...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747695/compounds-that-enhance-the-tailing-activity-of-moloney-murine-leukemia-virus-reverse-transcriptase
#2
Yoshiyuki Ohtsubo, Yuji Nagata, Masataka Tsuda
In a previous study, we showed that MMLV-RT has a strong terminal transferase activity, and that the C-, G-, and T-tailing activities are enhanced by dGMP, dCMP, and dAMP, respectively. In this study, to achieve faster reaction and higher tailing efficiency, we screened other compounds for the ability to enhance the tailing activities of MMLV-RT, and determined the corresponding optimal concentrations. The C-, G-, and T-tailing activities were enhanced by guanine, cytosine, and adenine, respectively, and by derivatives thereof, suggesting a transient Watson-Click base pairing between an enhancer molecule and the nucleotide to be incorporated...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28746826/electrophysiological-properties-of-neurons-and-synapses-in-the-lateral-habenular-complex-lhb
#3
REVIEW
Franziska Wagner, Torsten Weiss, Rüdiger W Veh
Animal including human behavior is highly sophisticated. Besides reflective actions it is largely based on the desire for magnificent internal feelings, which are provided by the reward system. Its counterpart an "anti-reward" system is mainly composed of the lateral habenular complex (LHb) and its extensive interconnections with the monoaminergic cell groups in the mid- and hindbrain. The present review focuses on the neuronal composition and the internal signaling in the LHb. Morphologically six distinct types of neurons (spherical, fusiform-1, fusiform-2, polymorphic, vertical, neurogliaform) can be identified...
July 23, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28746820/the-role-of-damps-and-pamps-in-inflammation-mediated-vulnerability-of-atherosclerotic-plaques
#4
Vikrant Rai, Devendra K Agrawal
Atherosclerosis is a chronic inflammatory disease resulting in the formation of the atherosclerotic plaque. Plaque formation starts with the inflammation in fatty streak and progress through atheroma, atheromatous plaque, and fibroatheroma leading to development of stable plaque. Hypercholesterolemia, dyslipidemia, hyperglycemia are the risk factors for atherosclerosis. Inflammation, infection with viruses and bacteria, and dysregulation in the endothelial and vascular smooth muscle cells leads to advanced plaque formation...
July 26, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28743038/physiological-vascular-and-nanomechanical-assessment-of-hybrid-poplar-leaf-traits-in-micropropagated-plants-and-plants-propagated-from-root-cuttings-a-contribution-to-breeding-programs
#5
Jaroslav Ďurkovič, Hana Husárová, Lucia Javoříková, Ingrid Čaňová, Miriama Šuleková, Monika Kardošová, Ivan Lukáčik, Miroslava Mamoňová, Rastislav Lagaňa
Micropropagated plants experience significant stress from rapid water loss when they are transferred from an in vitro culture to either greenhouse or field conditions. This is caused both by inefficient stomatal control of transpiration and the change to a higher light intensity and lower humidity. Understanding the physiological, vascular and biomechanical processes that allow micropropagated plants to modify their phenotype in response to environmental conditions can help to improve both field performance and plant survival...
July 13, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28741645/inflammasome-and-autophagy-regulation-a-two-way-street
#6
Qian Sun, Jie Fan, Timothy R Billiar, Melanie J Scott
Inflammation plays a significant role in protecting hosts against pathogens. Inflammation induced by non-infectious, endogenous agents can be detrimental, and if excessive can result in organ and tissue damage. The inflammasome is a major innate immune pathway that can be activated via both exogenous pathogen-associated molecular patterns (PAMPs) and endogenous damage-associated molecular patterns (DAMPs). Inflammasome activation involves formation and oligomerization of a protein complex including a NOD-like receptor (NLR), an adaptor protein (ASC) and procaspase-1...
July 24, 2017: Molecular Medicine
https://www.readbyqxmd.com/read/28741155/length-change-patterns-and-shape-of-a-grafted-tendon-after-anatomical-medial-patellofemoral-ligament-reconstruction-differs-from-that-in-a-healthy-knee
#7
Shuji Nakagawa, Yuji Arai, Hiroaki Inoue, Manabu Hino, Yuta Fujii, Shintaro Komaki, Kazuya Ikoma, Keiichiro Ueshima, Hiroyoshi Fujiwara, Toshikazu Kubo
PURPOSE: Recurrent patellar dislocation is currently treated with anatomical reconstruction of the medial patellofemoral ligament (MPFL), and favourable postoperative outcomes have been reported. However, it is uncertain if healthy MPFL function is restored by anatomical reconstruction. The hypothesis in this study was that stabilization of the patella following MPFL reconstruction would be improved compared with that before surgery, but that function of the grafted tendon would differ from that of a healthy MPFL...
July 24, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28740205/a-diatomic-elastic-metamaterial-for-tunable-asymmetric-wave-transmission-in-multiple-frequency-bands
#8
Bing Li, Sagr Alamri, K T Tan
Unidirectional/asymmetric transmission of acoustic/elastic waves has recently been realized by linear structures. Research related to unidirectionality of wave propagation has received intense attention due to potentially transformative and unique wave control applications. However, asymmetric transmission performance in existing devices usually occurs only in a narrow frequency band, and the asymmetric frequencies are always within ultrasound range (above 20 kHz). In this work, we design and propose a linear diatomic elastic metamaterial using dual-resonator concept to obtain large asymmetric elastic wave transmission in multiple low frequency bands...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28737502/intrinsic-plasmaron-in-warm-graphene
#9
Daqing Liu, Shueyue Chen, Shengli Zhang, Ning Ma
Basing on a self-consistent method, we predict theoretically that there exists intrinsic plasmaron in graphene at nonzero temperature and it is a well defined mode, as shown by the result of Landau damping. We find that there are sharp differences between the discussed system and the QCD/QED system. Firstly, the thermal mass is proportional to α<sub>g</sub><sup>3/4</sup>T but not α<sub>g</sub>T. Secondly, at long wavelength region, the fermion channel and plasmaron channel are nearly degenerate and furthermore, the energy difference between fermion and plasmaron becomes more and more larger with increasing q at the region q>q<sub>c</sub>...
July 24, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28734285/extension-of-the-d3-dispersion-coefficient-model
#10
Eike Caldeweyher, Christoph Bannwarth, Stefan Grimme
A new model, termed D4, for the efficient computation of molecular dipole-dipole dispersion coefficients is presented. As in the related, well established D3 scheme, these are obtained as a sum of atom-in-molecule dispersion coefficients over atom pairs. Both models make use of dynamic polarizabilities obtained from first-principles time-dependent density functional theory calculations for atoms in different chemical environments employing fractional atomic coordination numbers for interpolation. Different from the D3 model, the coefficients are obtained on-the-fly by numerical Casimir-Polder integration of the dynamic, atomic polarizabilities α(iω)...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28734284/cage-model-of-polar-fluids-finite-cage-inertia-generalization
#11
W T Coffey, M Zarifakis, Y P Kalmykov, S V Titov, W J Dowling, A S Titov
The itinerant oscillator model describing rotation of a dipole about a fixed axis inside a cage formed by its surrounding polar molecules is revisited in the context of modeling the dielectric relaxation of a polar fluid via the Langevin equation. The dynamical properties of the model are studied by averaging the Langevin equations describing the complex orientational dynamics of two bodies (molecule-cage) over their realizations in phase space so that the problem reduces to solving a system of three index linear differential-recurrence relations for the statistical moments...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28733885/a-simple-and-rapid-in-vitro-test-for-large-scale-screening-of-fungal-endophytes-from-drought-adapted-australian-wild-plants-for-conferring-water-deprivation-tolerance-and-growth-promotion-in-nicotiana-benthamiana-seedlings
#12
Khondoker M G Dastogeer, Hua Li, Krishnapillai Sivasithamparam, Michael G K Jones, Stephen J Wylie
Some fungal endophytes confer novel phenotypes and enhance existing ones in plants, including tolerance to water deprivation stress. A range of fungal endophytes was isolated from wild Nicotiana plants growing in arid parts of northern Australia. These were screened for ability to enhance water deprivation stress tolerance by inoculating seedlings of the model plant N. benthamiana in two in vitro tests. Sixty-eight endophyte isolates were co-cultivated with N. benthamiana seedlings on either damp filter paper or on agar medium before being subjected to water deprivation...
July 21, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28733578/protecting-quantum-fisher-information-of-n-qubit-ghz-state-by-weak-measurement-with-flips-against-dissipation
#13
Yu Chen, Jian Zou, Zheng-Wen Long, Bin Shao
In this paper we propose a scheme by using weak-measurement-based pre- and post-flips (WMPPF) to protect the average quantum Fisher information (QFI) in the independent amplitude-damping channel (ADC) for N-qubit GHZ state and generalized N-qubit GHZ states. We also discuss the weak measurement and quantum measurement reversal (WMQMR) with the same ADC. Based on the analytical and numerical results we obtain the main result: the WMPPF can reduce the effect of dissipation on the average QFI of the phase or the frequency for GHZ state and some generalized GHZ states, and the WMQMR can reduce the effect of dissipation on the average fidelity for GHZ state and generalized GHZ states in ADC...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28732778/functional-analysis-of-the-mapk-pathways-in-fungi
#14
Domingo Martínez-Soto, José Ruiz-Herrera
The Mitogen-Activated Protein Kinase (MAPK) signaling pathways constitute one of the most important and evolutionarily conserved mechanisms for the perception of extracellular information in all the eukaryotic organisms. The MAPK pathways are involved in the transfer to the cell of the information perceived from extracellular stimuli, with the final outcome of activation of different transcription factors that regulate gene expression in response to them. In all species of fungi, the MAPK pathways have important roles in their physiology and development; e...
July 18, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28732159/remote-single-molecule-switching-identification-and-nano-engineering-of-hot-electron-induced-tautomerization
#15
Jens Kügel, Markus Leisegang, Markus Böhme, Andreas Krönlein, Aimee Sixta, Matthias Bode
Molecular electronics where single molecules perform basic functionalities of digital circuits is a fascinating concept that one day may augment or even replace nowadays semiconductor technologies. The tautomerization of molecules, i.e., the bistable functional position of hydrogen protons within an organic frame, has recently been intensively discussed as a potential avenue towards nano-scale switches. It has been shown that tautomerization can be triggered locally or non-locally, i.e. by a scanning tunneling microscope (STM) tip positioned directly above or in close vicinity to the molecule...
July 21, 2017: Nano Letters
https://www.readbyqxmd.com/read/28729393/time-course-effects-of-aerobic-physical-training-in-the-prevention-of-cigarette-smoke-induced-copd
#16
Alessandra Choqueta Toledo-Arruda, Rodolfo Paula Vieira, Flavia Alessandra Guarnier, Camila Liyoko Suehiro, Agostinho Caleman-Neto, Clarice Rosa Olivo, Petra Mello Motta Arantes, Francine Maria Almeida, Fernanda Degobbi Tenorio Quirino Dos Santos Lopes, Ercy Mara Cipulo Ramos, Rubens Cecchini, Chin Jia Lin, Mílton A Martins
A previous study by our group showed that regular exercise training (ET) attenuated pulmonary injury in an experimental model of chronic exposure to cigarette smoke (CS) in mice, but the time-course effects of the mechanisms involved in this protection remain poorly understood. We evaluated the temporal effects of regular ET in an experimental model of chronic CS exposure. MaleC57BL/6 mice were divided into four groups: Control (sedentary+air), Exercise (aerobic training+air), Smoke (sedentary+smoke) and Smoke+Exercise (aerobic training+smoke)...
July 20, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28724800/siglec-g-represses-damp-mediated-effects-on-t-cells
#17
Tomomi Toubai, Corinne Rossi, Katherine Oravecz-Wilson, Cynthia Zajac, Chen Liu, Thomas Braun, Hideaki Fujiwara, Julia Wu, Yaping Sun, Stuart Brabbs, Hiroya Tamaki, John Magenau, Pang Zheng, Yang Liu, Pavan Reddy
The role of negative regulators or suppressors of the damage-associated molecular pattern-mediated (DAMP-mediated) stimulation of innate immune responses is being increasingly appreciated. However, the presence and function of suppressors of DAMP-mediated effects on T cells, and whether they can be targeted to mitigate T cell-dependent immunopathology remain unknown. Sialic acid-binding immunoglobulin-like lectin G (Siglec-G) is a negative regulator of DAMP-mediated responses in innate immune cells, but its T cell-autonomous role is unknown...
July 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28723682/release-of-danger-associated-molecular-patterns-following-chemotherapy-does-not-induce-immunoparalysis-in-leukemia-patients
#18
Kim Timmermans, Guus P Leijte, Matthijs Kox, Gert Jan Scheffer, Nicole M A Blijlevens, Peter P Pickkers
Chemotherapy may result in the release of danger-associated molecular patterns (DAMPs), which can cause immunoparalysis (deactivation of the immune system). We investigated DAMPs following chemotherapy and their relationship with markers of immunoparalysis in leukemia patients. In 6 patients with acute myeloid leukemia or myelodysplastic syndrome and 12 healthy subjects, DAMPs, cytokines, and markers of immunoparalysis were determined before and during the first week after chemotherapy initiation. In the patients, plasma levels of nuclear DNA (a marker of general DAMP release) were profoundly increased before chemotherapy and further increased 4-6 h afterwards, while the specific DAMP mitochondrial DNA showed only a trend towards increase...
July 20, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28722681/the-role-of-toll-like-receptor-4-in-tumor-microenvironment
#19
REVIEW
Jing Li, Fan Yang, Feng Wei, Xiubao Ren
Tumors are closely related to chronic inflammation, during which there are various changes in inflammatory sites, such as immune cells infiltration, pro-inflammation cytokines production, and interaction between immune cells and tissue cells. Besides, substances, released from both tissue cells attacked by exogenous etiologies, also act on local cells. These changes induce a dynamic and complex microenvironment favorable for tumor growth, invasion, and metastasis. The toll-like receptor 4 (TLR4) is the first identified member of the toll-like receptor family that can recognize pathogen-associated molecular patterns (PAMPs) and damage-associated molecular pattern (DAMPs)...
July 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28720850/energy-dissipation-pathways-in-few-layer-mos2-nanoelectromechanical-systems
#20
Bernard R Matis, Brian H Houston, Jeffrey W Baldwin
Free standing, atomically thin transition metal dichalcogenides are a new class of ultralightweight nanoelectromechanical systems with potentially game-changing electro- and opto-mechanical properties, however, the energy dissipation pathways that fundamentally limit the performance of these systems is still poorly understood. Here, we identify the dominant energy dissipation pathways in few-layer MoS2 nanoelectromechanical systems. The low temperature quality factors and resonant frequencies are shown to significantly decrease upon heating to 293 K, and we find the temperature dependence of the energy dissipation can be explained when accounting for both intrinsic and extrinsic damping sources...
July 18, 2017: Scientific Reports
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