Shir Nevo, Noga Frenkel, Noam Kadouri, Tom Gome, Noa Rosenthal, Tal Givony, Ayelet Avin, Cristina Peligero Cruz, Merav Kedmi, Moshit Lindzen, Shifra Ben Dor, Golda Damari, Ziv Porat, Rebecca Haffner-Krausz, Hadas Keren-Shaul, Yosef Yarden, Ariel Munitz, Dena Leshkowitz, Yael Goldfarb, Jakub Abramson
The thymus is a primary lymphoid organ that is essential for the establishment of adaptive immunity through generation of immunocompetent T cells. In response to various stress signals, the thymus undergoes acute but reversible involution. However, the mechanisms governing its recovery are incompletely understood. Here, we used a dexamethasone-induced acute thymic involution mouse model to investigate how thymic hematopoietic cells (excluding T cells) contribute to thymic regeneration. scRNA-seq analysis revealed marked transcriptional and cellular changes in various thymic populations and highlighted thymus-resident innate lymphoid cells type 2 (ILC2) as a key cell type involved in the response to damage...
January 12, 2024: Science Immunology