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https://www.readbyqxmd.com/read/29453594/time-to-first-event-versus-recurrent-event-analysis-points-to-consider-for-selecting-a-meaningful-analysis-strategy-in-clinical-trials-with-composite-endpoints
#1
Geraldine Rauch, Meinhard Kieser, Harald Binder, Antoni Bayes-Genis, Antje Jahn-Eimermacher
BACKGROUND: Composite endpoints combining several event types of clinical interest often define the primary efficacy outcome in cardiologic trials. They are commonly evaluated as time-to-first-event, thereby following the recommendations of regulatory agencies. However, to assess the patient's full disease burden and to identify preventive factors or interventions, subsequent events following the first one should be considered as well. This is especially important in cohort studies and RCTs with a long follow-up leading to a higher number of observed events per patients...
February 16, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29453386/anti-fibrotic-effects-of-cxcr4-targeting-i-body-ad-114-in-preclinical-models-of-pulmonary-fibrosis
#2
K Griffiths, D M Habiel, J Jaffar, U Binder, W G Darby, C G Hosking, A Skerra, G P Westall, C M Hogaboam, M Foley
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease that is prevalent in individuals >50 years of age, with a median survival of 3-5 years and limited therapeutic options. The disease is characterized by collagen deposition and remodeling of the lung parenchyma in a process that is thought to be driven by collagen-expressing immune and structural cells. The G-protein coupled C-X-C chemokine receptor 4, CXCR4, is a candidate therapeutic target for IPF owing to its role in the recruitment of CXCR4 + fibrocytes from the bone marrow to fibrotic lung tissue and its increased expression levels by structural cells in fibrotic lung tissue...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453375/self-supporting-co-3-o-4-graphene-hybrid-films-as-binder-free-anode-materials-for-lithium-ion-batteries
#3
Shouling Wang, Ronghua Wang, Jie Chang, Ning Hu, Chaohe Xu
A self-supporting Co 3 O 4 /graphene hybrid film has been constructed via vacuum filtration of Co(OH) 2 nanosheet and graphene, followed by a two-step thermal treatment. Within the hybrid film, Co 3 O 4 nanoparticles with size of 40~60 nm uniformly in-situ grew on the surface of graphene, forming a novel porous and interleaved structure with strong interactions between Co 3 O 4 nanoparticles and graphene. Such fascinating microstructures can greatly facilitate interfacial electron transportation and accommodate the volume changes upon Li ions insertion and extraction...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29451343/molecular-tectonics-with-di-and-trinuclear-organometallic-tin-compounds
#4
Irán Rojas-León, Hazem Alnasr, Klaus Jurkschat, Maria G Vasquez-Ríos, Irán F Hernández-Ahuactzi, Herbert Höpfl
Di- and trinuclear organometallic tin (IV) complexes, in which the metal atoms are separated by large aromatic connectors, are useful building blocks for self-assembly. This is demonstrated by the preparation of [1+1], [2+2] and [2+3] macrocyclic and cage-type structures in combination with organic aromatic dicarboxylates. The linkage of the metal atoms by organic binders and the option of varying the number of reactive M-X sites generate versatile building blocks enabling molecular tectonics instead of the node-based strategy generally employed in metallo-supramolecular self-assembly...
February 16, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29448693/3d-mnco%C3%A2-o-4-5-nanorod-arrays-on-ni-foam-as-binder-free-anodes-for-li-ion-batteries
#5
Qingqing Ren, Chang Liu, Zhenbo Wang, Ke Ke, Siwen Zhang, Bosi Yin
It is a key to develop novel electrode materials with high energy and power density for advanced batteries to meet the demand of electric vehicles (EVs). Manganese cobalt oxides which can react with a large number of ions from the electrolyte for electrochemical energy storage are developing into the promising electrode materials. In this work, well-ordered MnCo2O4.5 nanorod arrays (MCO NRAs) are prepared on Ni foam by a general route of hydrothermal growth and low-temperature annealing treatment. The samples deliver a high initial capacity of 1402...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29444930/immunophenotyping-of-newly-diagnosed-and-recurrent-glioblastoma-defines-distinct-immune-exhaustion-profiles-in-peripheral-and-tumor-infiltrating-lymphocytes
#6
Malte Mohme, Simon Schliffke, Cecile L Maire, Alessandra Rünger, Laura Glau, Klaus C Mende, Jakob Matschke, Christina Gehbauer, Nuray Akyüz, Svenja Zapf, Mareike Holz, Miriam Schaper, Tobias Martens, Nils O Schmidt, Sven Peine, Manfred Westphal, Mascha Binder, Eva Tolosa, Katrin Lamszus
PURPOSE: Immunotherapeutic treatment strategies for glioblastoma (GBM) are under investigation in clinical trials. However, our understanding of the immune phenotype of GBM-infiltrating T-cells (TILs) and changes during disease progression is limited. Deeper insight is urgently needed to therapeutically overcome tumor-induced immune exhaustion. EXPERIMENTAL DESIGN: We used flow-cytometry and cytokine assays to profile TILs and blood lymphocytes (PBL) from GBM patients, comparing newly diagnosed or recurrent GBM to long-term survivors (LTS) and healthy donors...
February 14, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29444205/ssbio-a-python-framework-for-structural-systems-biology
#7
Nathan Mih, Elizabeth Brunk, Ke Chen, Edward Catoiu, Anand Sastry, Erol Kavvas, Jonathan M Monk, Zhen Zhang, Bernhard O Palsson, Alfonso Valencia
Summary: Working with protein structures at the genome-scale has been challenging in a variety of ways. Here, we present ssbio, a Python package that provides a framework to easily work with structural information in the context of genome-scale network reconstructions, which can contain thousands of individual proteins. The ssbio package provides an automated pipeline to construct high quality genomescale models with protein structures (GEM-PROs), wrappers to popular third-party programs to compute associated protein properties, and methods to visualize and annotate structures directly in Jupyter notebooks, thus lowering the barrier of linking 3D structural data with established systems workflows...
February 12, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29443862/red-tides-mass-casualty-and-whole-blood-at-sea-red-tides
#8
Benjamin T Miller, Andrew H Lin, Susan C Clark, Andrew P Cap, Joseph J Dubose
BACKGROUND: The U.S. Navy's casualty-receiving ships provide remote damage control resuscitation (RDCR) platforms to treat injured combatants deployed afloat and ashore. We report a significant mass casualty incident aboard the USS Bataan, and the most warm fresh whole blood (WFWB) transfused at sea for traumatic hemorrhagic shock since the Vietnam War. METHODS: Casualty-receiving ships have robust medical capabilities, including a frozen blood bank with packed red blood cells (pRBC) and fresh frozen plasma (FFP)...
February 13, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29443357/low-energy-stereotactic-radiotherapy-for-treatment-of-exudative-age-related-macular-degeneration-in-a-treat-and-extend-regimen
#9
Katja Hatz, Frank Zimmermann, Dimitrios Kardamakis, Emmanouil Lazaridis, Cengiz Türksever, Jörg Binder, Alexandros Papachristofilou, Christian Prünte
BACKGROUND AND OBJECTIVE: To evaluate the effectiveness and safety of low-energy stereotactic radiotherapy (SRT) combined with anti-vascular endothelial growth factor (VEGF) treatment following a treat-and-extend regimen (TER) in wet age-related macular degeneration (AMD). PATIENTS AND METHODS: Before/after SRT, the authors compared retrospective consecutive case series of 50 patients requiring frequent anti-VEGF treatment (every 4 or 6 weeks) in wet AMD, treated with a single session of SRT and TER (same manner pre/post-SRT)...
February 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29442650/electrospun-lifepo%C3%A2-c-composite-fiber-membrane-as-a-binder-free-self-standing-cathode-for-power-lithium-ion-battery
#10
Li-Li Chen, Xiang-Qian Shen, Mao-Xiang Jing, Sheng-Wen Zhu, Zhi-Chao Pi, Jing-Quan Li, Hong-Ai Zhai, Ke-Song Xiao
A LiFePO4/C composite fiber membrane was fabricated by the electrospinning method and subsequent thermal treatment. The thermal decomposition process was analyzed by TG/DSC, the morphology, microstructure and composition were studied using SEM, TEM, XRD, Raman, respectively. The results indicated that the prepared LiFePO4/C composite fibers were composed of nanosized LiFePO4 crystals and amorphous carbon coatings, which formed a three dimensional (3D) long-range networks, greatly enhanced the electronic conductivity of LiFePO4 electrode up to 3...
July 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442007/development-and-analytical-characterization-of-a-new-antiparasitic-fenbendazole-compound-tablet-and-pharmacokinetic-investigations-after-its-oral-administration-to-dogs
#11
Cunchun Dai, Shaoqi Qu, Ruili Zhang, Li Zhao, Yuwen Li, Jiajia Zhu, Chunmei Wang, Hui Guo, Zhihui Hao
The objective of this study was to prepare a new compound fenbendazole tablet containing 29.7 % fenbendazole, 1.50 % praziquantel and 0.059 % ivermectin for oral administration. The tablets were successfully prepared using mannitol as filler agent, polyvinyl polypyrrolidone as disintegrant, 5 % povidone (PVAK30) as a binder agent and magnesium stearate as lubricant. The appearance, hardness, fragility, time limit of disintegration and fenbendazole dissolution at 45 min all met the technical standards of the Ministry of Agriculture for the People's Republic of China...
February 1, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29441684/development-of-drug-discovery-screening-system-by-molecular-interaction-kinetics-mass-spectrometry
#12
Naoko Obi, Tetsuya Fukuda, Noboru Nakayama, John Ervin, Yasuhiko Bando, Toshihide Nishimura, Satoru Nagatoishi, Kouhei Tsumoto, Takeshi Kawamura
RATIONALE: Drug discovery studies invariably require qualitative and quantitative analyses of target compounds at every stage of drug discovery. We have developed a system combining molecular interaction analysis and mass spectrometry (LC-MS) using the principle of nano pore optical interferometry (nPOI) called molecular interaction kinetics-mass spectrometry (MIK-MS). Since nPOI has high binding capacity, the bond-dissociated compound can be directly detected using LC-MS. In this study, we use carbonic anhydrase (CA) II as a ligand and apply six small compounds as analytes and report the affinity analysis using MIK-MS...
February 14, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29441010/an-aged-canid-with-behavioral-deficits-exhibits-blood-and-cerebrospinal-fluid-amyloid-beta-oligomers
#13
Clare Rusbridge, Francisco J Salguero, Monique Antoinette David, Kiterie M E Faller, Jose T Bras, Rita J Guerreiro, Angela C Richard-Londt, Duncan Grainger, Elizabeth Head, Sebastian G P Brandner, Brian Summers, John Hardy, Mourad Tayebi
Many of the molecular and pathological features associated with human Alzheimer disease (AD) are mirrored in the naturally occurring age-associated neuropathology in the canine species. In aged dogs with declining learned behavior and memory the severity of cognitive dysfunction parallels the progressive build up and location of Aβ in the brain. The main aim of this work was to study the biological behavior of soluble oligomers isolated from an aged dog with cognitive dysfunction through investigating their interaction with a human cell line and synthetic Aβ peptides...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29440923/managing-hyperparathyroidism-in-hemodialysis-role-of-etelcalcetide
#14
REVIEW
Keith E Eidman, James B Wetmore
Secondary hyperparathyroidism (SHPT) is common in patients receiving maintenance hemodialysis and is associated with adverse outcomes. Currently, SHPT is managed by reducing circulating levels of phosphate with oral binders and parathyroid hormone (PTH) with vitamin D analogs and/or the calcimimetic cinacalcet. Etelcalcetide, a novel calcimimetic administered intravenously (IV) at the end of a hemodialysis treatment session, effectively reduces PTH in clinical trials when given thrice weekly. Additional clinical effects include reductions in circulating levels of phosphate and FGF-23 and an improved profile of markers of bone turnover...
2018: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29439243/atomic-structures-of-low-complexity-protein-segments-reveal-kinked-%C3%AE-sheets-that-assemble-networks
#15
Michael P Hughes, Michael R Sawaya, David R Boyer, Lukasz Goldschmidt, Jose A Rodriguez, Duilio Cascio, Lisa Chong, Tamir Gonen, David S Eisenberg
Subcellular membraneless assemblies are a reinvigorated area of study in biology, with spirited scientific discussions on the forces between the low-complexity protein domains within these assemblies. To illuminate these forces, we determined the atomic structures of five segments from protein low-complexity domains associated with membraneless assemblies. Their common structural feature is the stacking of segments into kinked β sheets that pair into protofilaments. Unlike steric zippers of amyloid fibrils, the kinked sheets interact weakly through polar atoms and aromatic side chains...
February 9, 2018: Science
https://www.readbyqxmd.com/read/29436389/deletion-of-irf8-dependent-dendritic-cells-abrogates-pro-atherogenic-adaptive-immunity
#16
Marc Clément, Yacine Haddad, Juliette Raffort, Fabien Lareyre, Stephen A Newland, Leanne Masters, James Harrison, Maria Ozsvar Kozma, Patrick Bruneval, Christoph J Binder, Soraya Taleb, Ziad Mallat
<u>Rationale:</u> Despite an established role for adaptive immune responses in atherosclerosis, the contribution of dendritic cells (DCs) and their various subsets is still poorly understood. <u>Objective:</u> Here, we address the role of IRF8-dependent DCs (lymphoid CD8α + and their developmentally related non-lymphoid CD103 + DCs) in the induction of pro-atherogenic immune responses during high fat feeding. <u>Methods and Results:</u> Using a fate mapping technique to track DCs originating from a DNGR1 + precursor ( Clec9a +/cre Rosa +/EYFP mice), we first show that YFP hi MCD11c hi MHCII hi DCs are present in the atherosclerotic aorta of low-density lipoprotein receptor deficient ( Ldlr -/- ) mice and are CD11b-CD103 + IRF8 hi Restricted deletion of IRF8 in DCs ( Irf8 flox/flox Cd11c Cre ) reduces the accumulation of CD11c hi MHCII hi DCs in the aorta without affecting CD11b + CD103 - DCs or macrophages, but completely abolishes the accumulation of aortic CD11b - CD103 + DCs...
February 7, 2018: Circulation Research
https://www.readbyqxmd.com/read/29433411/spinal-accessory-nerve-repair-using-a-direct-nerve-transfer-from-the-upper-trunk-results-with-2-years-follow-up
#17
Adeline Cambon-Binder, Lynda Preure, Heba Dubert-Khalifa, Pierre-Sylvain Marcheix, Zoubir Belkheyar
Spinal accessory nerve grafting requires identification of both nerve stumps in the scar tissue, which is sometimes difficult. We propose a direct nerve transfer using a fascicle from the posterior division of the upper trunk. We retrospectively reviewed 11 patients with trapezius palsy due to an iatrogenic injury of the spinal accessory nerve in nine cases. The mean age was 38 years (range 21-59). Preoperatively, patients showed shoulder weakness and limited range of motion. At a mean follow-up of 25 months, active shoulder abduction improvement averaged 57°...
January 1, 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29433316/in-situ-target-engagement-studies-in-adherent-cells
#18
Hanna Axelsson, Helena Almqvist, Magdalena Otrocka, Michaela Vallin, Sara Lundqvist, Pia Hansson, Ulla Karlsson, Thomas Lundbäck, Brinton Seashore-Ludlow
A prerequisite for successful drugs is effective binding of the desired target protein in the complex environment of a living system. Drug-target engagement has typically been difficult to monitor in physiologically relevant models, and with current methods, especially, while maintaining spatial information. One recent technique for quantifying drug-target engagement is the cellular thermal shift assay (CETSA), in which ligand-induced protein stabilization is measured after a heat challenge. Here, we describe a CETSA protocol in live A431 cells for p38α (MAPK14), where remaining soluble protein is detected in situ using high-content imaging in 384-well, microtiter plates...
February 12, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29431842/fept-co-core-shell-nanoparticle-based-anisotropic-nanocomposites-and-their-exchange-spring-behavior
#19
Deyao Li, Hui Wang, Zhenhui Ma, Xin Liu, Ying Dong, Zhiqi Liu, Tianli Zhang, Chengbao Jiang
Anisotropic exchange-coupled nanocomposites provide us a salient candidate for the new generation of permanent magnets owing to their huge predicted maximum energy product. However, previous research basically focused on thin films or bulk materials and the impact of easy-axis alignment on the exchange coupling behavior is not clear. Herein, strongly coupled FePt/Co core/shell nanoparticles with single-phase-like hysteresis loops were synthesized by the seed mediated method. Then, these nanoparticles were successfully aligned by the external magnetic field and fixed in an acrylic binder, so that FePt/Co core/shell nanoparticle-based anisotropic nanocomposites were obtained...
February 12, 2018: Nanoscale
https://www.readbyqxmd.com/read/29431793/hydrogen-evolution-reactions-boosted-by-bridge-bonds-between-electrocatalysts-and-electrodes
#20
Guanglei Liu, Zhanyu Wang, Lianhai Zu, Yan Zhang, Yutong Feng, Shihe Yang, Yu Jia, Songyou Wang, Chi Zhang, Jinhu Yang
The interfacial interactions between nanostructured electrode materials and electrodes play an important part in the performance enhancement of electrochemical energy devices. However, the mechanism of interfacial interactions, as well as its influence on device performance, still remains unclear and is rarely studied. In this work, a CoS2 nanobelt catalyst assembled on Ti foil (CoS2 nanobelts/Ti) is prepared through in situ chemical conversions and chosen as an example to probe the interfacial interactions between the CoS2 catalyst and the Ti electrode, and the correlation between the interfacial interaction and the hydrogen evolution reaction (HER) performance...
February 12, 2018: Nanoscale
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