keyword
MENU ▼
Read by QxMD icon Read
search

Binders

keyword
https://www.readbyqxmd.com/read/28213333/hmba-is-a-putative-hsp70-activator-stimulating-hexim1-expression-that-is-down-regulated-by-estrogen
#1
Rati Lama, Chunfang Gan, Nethrie Idippily, Viharika Bobba, David Danielpour, Monica Montano, Bin Su
Hexamethylene bis-acetamide inducible protein 1 (HEXIM1) is identified as a novel inhibitor of estrogen stimulated breast cell growth, and it suppresses estrogen receptor-α transcriptional activity. HEXIM1 protein level has been found to be downregulated by estrogens. Recently, HEXIM1 has been found to inhibit androgen receptor transcriptional activity as well. Researchers have used Hexamethylene bis-acetamide (HMBA) for decades to stimulate HEXIM1 expression, which also inhibit estrogen stimulated breast cancer cell gene activation and androgen stimulated prostate cancer gene activation...
February 14, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28213278/identifying-overarching-excipient-properties-towards-an-in-depth-understanding-of-process-and-product-performance-for-continuous-twin-screw-wet-granulation
#2
N Willecke, A Szepes, M Wunderlich, J P Remon, C Vervaet, T De Beer
The overall objective of this work is to understand how excipient characteristics influence the process and product performance for a continuous twin-screw wet granulation process. The knowledge gained through this study is intended to be used for a Quality by Design (QbD)-based formulation design approach and formulation optimization. A total of 9 preferred fillers and 9 preferred binders were selected for this study. The selected fillers and binders were extensively characterized regarding their physico-chemical and solid state properties using 21 material characterization techniques...
February 14, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28211521/computer-aided-designing-of-immunosuppressive-peptides-based-on-il-10-inducing-potential
#3
Gandharva Nagpal, Salman Sadullah Usmani, Sandeep Kumar Dhanda, Harpreet Kaur, Sandeep Singh, Meenu Sharma, Gajendra P S Raghava
In the past, numerous methods have been developed to predict MHC class II binders or T-helper epitopes for designing the epitope-based vaccines against pathogens. In contrast, limited attempts have been made to develop methods for predicting T-helper epitopes/peptides that can induce a specific type of cytokine. This paper describes a method, developed for predicting interleukin-10 (IL-10) inducing peptides, a cytokine responsible for suppressing the immune system. All models were trained and tested on experimentally validated 394 IL-10 inducing and 848 non-inducing peptides...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211273/sub-bandgap-voltage-electroluminescence-and-magneto-oscillations-in-a-wse2-light-emitting-van-der-waals-heterostructure
#4
Johannes Binder, Freddie Withers, Maciej R Molas, Clement Faugeras, Karol Nogajewski, Kenji Watanabe, Takashi Taniguchi, Aleksey Kozikov, Andre K Geim, Kostya S Novoselov, Marek Potemski
We report on experimental investigations of an electrically driven WSe2 based light-emitting van der Waals heterostructure. We observe a threshold voltage for electroluminescence significantly lower than the corresponding single particle band gap of monolayer WSe2. This observation can be interpreted by considering the Coulomb interaction and a tunneling process involving excitons, well beyond the picture of independent charge carriers. An applied magnetic field reveals pronounced magneto-oscillations in the electroluminescence of the free exciton emission intensity with a 1/B-periodicity...
February 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/28208710/metabolism-of-zearalenone-and-its-major-modified-forms-in-pigs
#5
Sabina B Binder, Heidi E Schwartz-Zimmermann, Elisabeth Varga, Gerlinde Bichl, Herbert Michlmayr, Gerhard Adam, Franz Berthiller
The Fusarium mycotoxin zearalenone (ZEN) can be conjugated with polar molecules, like sugars or sulfates, by plants and fungi. To date, the fate of these modified forms of ZEN has not yet been elucidated in animals. In order to investigate whether ZEN conjugates contribute to the total ZEN exposure of an individual, ZEN (10 µg/kg b.w.) and equimolar amounts of two of its plant metabolites (ZEN-14-O-β-glucoside, ZEN-16-O-β-glucoside) and of one fungal metabolite (ZEN-14-sulfate) were orally administered to four pigs as a single bolus using a repeated measures design...
February 8, 2017: Toxins
https://www.readbyqxmd.com/read/28208323/upper-and-lower-critical-decay-exponents-of-ising-ferromagnets-with-long-range-interaction
#6
Toshiki Horita, Hidemaro Suwa, Synge Todo
We investigate the universality class of the finite-temperature phase transition of the two-dimensional Ising model with the algebraically decaying ferromagnetic long-range interaction, J_{ij}=|r[over ⃗]_{i}-r[over ⃗]_{j}|^{-(d+σ)}, where d (=2) is the dimension of the system and σ is the decay exponent, by means of the order-N cluster-algorithm Monte Carlo method. In particular, we focus on the upper and lower critical decay exponents, the boundaries between the mean-field-universality, intermediate, and short-range-universality regimes...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28207952/di-nickel-salphen-complexes-as-binders-of-human-telomeric-dimeric-g-quadruplexes
#7
Ramon Vilar, Chun-Qiong Zhou, Ting-Cong Liao, Zi-Qi Li, Jorge Gonzalez-Garcia, Matthew Reynolds, Min Zou
Three new polyether-tethered di-nickel-salphen complexes (2a-c) have been synthesized and fully characterized by NMR spectroscopy, mass spectrometry and elemental analyses. The binding affinity and selectivity of these complexes and of the parent mono-nickel complex (1) towards dimeric quadruplex DNA have been determined by UV-Vis titrations, fluorescence spectroscopy, CD spectroscopy and electrophoresis. These studies have shown that the di-nickel-salphen complex with the longest polyether linker (2c) has higher binding affinity and selectivity towards dimeric quadruplexes (over monomeric quadruplexes) than the di-nickel-salphen complexes with the shorter polyether linkers (2a and 2b)...
February 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28207835/identification-of-plant-cells-in-black-pigments-of-prehistoric-spanish-levantine-rock-art-by-means-of-a-multi-analytical-approach-a-new-method-for-social-identity-materialization-using-cha%C3%A3-ne-op%C3%A3-ratoire
#8
Esther López-Montalvo, Clodoaldo Roldán, Ernestina Badal, Sonia Murcia-Mascarós, Valentín Villaverde
We present a new multi-analytical approach to the characterization of black pigments in Spanish Levantine rock art. This new protocol seeks to identify the raw materials that were used, as well as reconstruct the different technical gestures and decision-making processes involved in the obtaining of these black pigments. For the first of these goals, the pictorial matter of the black figurative motifs documented at the Les Dogues rock art shelter (Ares del Maestre, Castellón, Spain) was characterized through the combination of physicochemical and archeobotanical analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28202413/engineered-antibody-ch2-domains-binding-to-nucleolin-isolation-characterization-and-improvement-of-aggregation
#9
De-Zhi Li, Rui Gong, Jun Zheng, Xi-Hai Chen, Dimiter S Dimitrov, Qi Zhao
Smaller recombinant antibody fragments are now emerging as alternatives of conventional antibodies. Especially, immunoglobulin (Ig) constant CH2 domain and engineered CH2 with improved stability are promising as scaffolds for selection of specific binders to various antigens. We constructed a yeast display library based on an engineered human IgG1 CH2 scaffold with diversified loop regions. A group of CH2 binders were isolated from this yeast display library by panning against nucleolin, which is a tumor-associated antigen involved in cell proliferation, tumor cell growth and angiogenesis...
February 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28194960/a-new-method-for-non-invasive-analysis-of-proteins-and-small-molecules-from-ancient-objects
#10
Marcello Manfredi, Elettra Barberis, Fabio Gosetti, Eleonora Conte, Giorgio Gatti, Clara Mattu, Elisa Robotti, Gleb Zilberstein, Igor Koman, Svetlana Zilberstein, Emilio Marengo, Pier Giorgio Righetti
Proteins and small molecules from ancient objects and cultural heritage can provide key information and contribute to study the context of objects and artists. However, all present- day protocols and strategies for the analysis of ancient samples are often invasive and require micro sampling. Here, we present a new method for the non-invasive analysis of proteins and small molecules: the technique uses a special ethyl-vinyl acetate film functionalized with strong cation/anion exchange and C8 resins, for interacting with both proteins and small molecules present on the surface of the objects, followed by LC-MS/MS analysis...
February 8, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28194884/long-term-safety-and-efficacy-of-bixalomer-in-hyperphosphatemic-patients-with-chronic-kidney-disease-not-on-dialysis
#11
Tadao Akizawa, Junko Tsukada, Chisato Kameoka, Kentarou Kuroishi, Yusuke Yamaguchi
Bixalomer, a metal-free, nonabsorbable phosphate binder, is approved in Japan to treat hyperphosphatemia in dialysis patients. Bixalomer is effective and has a favorable safety profile in predialysis patients with hyperphosphatemia. This study examined the long-term effectiveness and safety of bixalomer in predialysis patients with hyperphosphatemia. This was a 48-week, multicenter, open-label, phase 3 study in Japanese predialysis patients with hyperphosphatemia. Patients received bixalomer at an initial dose of 1500 mg/day, which was titrated to a maximum of 7500 mg/day depending on patients' serum phosphorus responses to bixalomer...
February 14, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28193211/display-of-single-chain-variable-fragments-on-bacteriophage-ms2-virus-like-particles
#12
Christopher A Lino, Jerri C Caldeira, David S Peabody
BACKGROUND: Virus-like particles (VLPs) of the RNA bacteriophage MS2 have many potential applications in biotechnology. MS2 VLPs provide a platform for peptide display and affinity selection (i.e. biopanning). They are also under investigation as vehicles for targeted drug delivery, using display of receptor-specific peptides or nucleic acid aptamers to direct their binding to specific cell-surface receptors. However, there are few molecules more suited to the precise targeting and binding of a cellular receptor than antibodies...
February 13, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28192970/antibody-mimetics-for-the-detection-of-small-organic-compounds-using-a-quartz-crystal-microbalance
#13
Eleni Koutsoumpeli, Christian Tiede, James Murray, Anna Ah-San Tang, Robin Stefan Bon, Darren Tomlinson, Steven D Johnson
Conventional immunoassays rely on antibodies that provide high affinity, specificity and selectivity against a target analyte. However, the use of antibodies for the detection of small-sized, non-immunogenic targets, such as pharmaceuticals and environmental contaminants presents a number of challenges. Recent advances in protein engineering have led to the emergence of antibody mimetics that offer the high affinity and specificity associated with antibodies but with reduced batch-to-batch variability, high stability and in vitro selection to ensure rapid discovery of binders against a wide range of targets...
February 1, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28191969/seekr-simulation-enabled-estimation-of-kinetic-rates-a-computational-tool-to-estimate-molecular-kinetics-and-its-application-to-trypsin-benzamidine-binding
#14
Lane William Votapka, Benjamin R Jagger, Alexandra L Heyneman, Rommie E Amaro
We present the Simulation Enabled Estimation of Kinetic Rates (SEEKR) package, a suite of open-source scripts and tools designed to enable researchers to perform multi-scale computation of the kinetics of molecular binding, unbinding, and transport using a combination of molecular dynamics, Brownian dynamics, and milestoning theory. To demonstrate its utility, we compute the kon, koff, and ∆Gbind for the protein trypsin with its noncovalent binder, benzamidine, and examine the kinetics and other results generated in the context of the new software, and compare our findings to previous studies performed on the same system...
February 13, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28191854/nanostructured-conductive-polymer-gels-as-a-general-framework-material-to-improve-electrochemical-performance-of-cathode-materials-in-li-ion-batteries
#15
Ye Shi, Xingyi Zhou, Jun Zhang, Andrea M Bruck, Andrew C Bond, Amy C Marschilok, Kenneth J Takeuchi, Esther S Takeuchi, Guihua Yu
Controlling architecture of electrode composites is of particular importance to optimize both electronic and ionic conduction within the entire electrode and improve the dispersion of active particles, thus achieving the best energy delivery from a battery. Electrodes based on conventional binder systems that consist of carbon additives and nonconductive binder polymers suffer from aggregation of particles and poor physical connections, leading to decreased effective electronic and ionic conductivities. Here we developed a three-dimensional (3D) nanostructured hybrid inorganic-gel framework electrode by in situ polymerization of conductive polymer gel onto commercial lithium iron phosphate particles...
February 13, 2017: Nano Letters
https://www.readbyqxmd.com/read/28190384/lactic-acid-bacteria-with-concomitant-il-17-il-23-and-tnf%C3%AE-binding-ability-for-the-treatment-of-inflammatory-bowel-disease
#16
Staša Kosler, Borut Štrukelj, Aleš Berlec
BACKGROUND: Neutralization of proinflammatory cytokines is an established strategy in the treatment of inflammatory bowel disease (IBD). Systemic anti-TNFα antibodies have been used in the clinics for several years, while anti-IL-17/IL-23 antibodies have been less successful so far. We report the development of safe lactic acid bacterium Lb. salivarius with the ability to simultaneously bind IL-17A, IL-23 and TNFα that could be administered orally for the treatment of IBD. METHODS: Three different cytokine-binding non-Ig scaffolds (anti-IL-17A fynomer, anti-IL-23-binding adnectin and anti-TNFα-binding affibody) were cloned and expressed in L...
10, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28189110/amplified-electrochemical-sensor-employing-cuo-swcnts-and-1-butyl-3-methylimidazolium-hexafluorophosphate-for-selective-analysis-of-sulfisoxazole-in-the-presence-of-folic-acid
#17
Hassan Karimi-Maleh, Fatemeh Amini, Ahmad Akbari, Moein Shojaei
In the present work, CuO nanoparticle decorated on single wall carbon nanotubes (CuO/SWCNTs) nanocomposite was successfully synthesized by chemical precipitation method and used for modification of carbon paste electrode (CPE) in the presence of 1-butyl-3-methylimidazolium hexafluorophosphate (1-B-3-MIHFP) liquid as binder. The novel voltammetric sensor was used as first electrochemical sensor for determination of sulfisoxazole (SFX). CuO/SWCNTs nanocomposite characterized by scanning electron microscopy (SEM) and X-ray powder diffraction (XRD) methods...
February 3, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28186432/development-of-anti-cd47-single-chain-variable-fragment-targeted-magnetic-nanoparticles-for-treatment-of-human-bladder-cancer
#18
Gashin Rezaei, Mahdi Habibi-Anbouhi, Morteza Mahmoudi, Kayhan Azadmanesh, Shima Moradi-Kalbolandi, Mahdi Behdani, Leila Ghazizadeh, Mohsen Abolhassani, Mohammad Ali Shokrgozar
AIM: To develop a novel anti-CD47 single-chain variable fragment (scFv) functionalized magnetic nanoparticles (MNPs) for targeting bladder cell lines and its applicability in thermotherapy. MATERIAL & METHODS: An immunized murine antibody phage display library was constructed and screened to isolate anti-CD47 binders. A scFv was selected and conjugated to MNPs which was then utilized to discriminate CD47(+) bladder cells along with assessing its efficacy in thermotherapy...
February 10, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28186183/carbon-coated-honeycomb-ni-mn-co-o-inverse-opal-a-high-capacity-ternary-transition-metal-oxide-anode-for-li-ion-batteries
#19
David McNulty, Hugh Geaney, Colm O'Dwyer
We present the formation of a carbon-coated honeycomb ternary Ni-Mn-Co-O inverse opal as a conversion mode anode material for Li-ion battery applications. In order to obtain high capacity via conversion mode reactions, a single phase crystalline honeycombed IO structure of Ni-Mn-Co-O material was first formed. This Ni-Mn-Co-O IO converts via reversible redox reactions and Li2O formation to a 3D structured matrix assembly of nanoparticles of three (MnO, CoO and NiO) oxides, that facilitates efficient reactions with Li...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28185853/sustainable-management-and-utilisation-of-concrete-slurry-waste-a-case-study-in-hong-kong
#20
Md Uzzal Hossain, Dongxing Xuan, Chi Sun Poon
With the promotion of environmental protection in the construction industry, the mission to achieve more sustainable use of resources during the production process of concrete is also becoming important. This study was conducted to assess the environmental sustainability of concrete slurry waste (CSW) management by life cycle assessment (LCA) techniques, with the aim of identifying a resource-efficient solution for utilisation of CSW in the production of partition wall blocks. CSW is the dewatered solid residues deposited in the sedimentation tank after washing out over-ordered/rejected fresh concrete and concrete trucks in concrete batching plants...
February 6, 2017: Waste Management
keyword
keyword
22893
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"