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Sessile serrated polyps

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https://www.readbyqxmd.com/read/28816376/acetic-acid-indigo-carmine-mixture-for-evaluating-the-margins-of-sessile-serrated-adenomas-polyps
#1
Shunsuke Yamamoto, Morteza Shafazand
Sessile serrated adenomas/polyps (SSA/Ps) have attracted increasing attention since their risk of developing into cancer was clarified [1]. Difficulty in determining their margins causes incomplete resection [2]. Although narrow-band imaging (NBI) and other advanced imaging systems are reportedly useful in evaluating these polyps [3, 4]. This article is protected by copyright. All rights reserved.
August 17, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28791327/use-of-endocytoscopy-for-identification-of-sessile-serrated-adenoma-polyps-and-hyperplastic-polyps-by-quantitative-image-analysis-of-the-luminal-areas
#2
Yushi Ogawa, Shin-Ei Kudo, Yuichi Mori, Nobunao Ikehara, Yasuharu Maeda, Kunihiko Wakamura, Masashi Misawa, Toyoki Kudo, Takemasa Hayashi, Hideyuki Miyachi, Atsushi Katagiri, Fumio Ishida, Haruhiro Inoue
BACKGROUND AND STUDY AIMS:  Recent studies that used magnifying chromoendoscopy and endocytoscopy (EC) to investigate endoscopic features of sessile serrated adenoma/polyps (SSA/Ps) suggested that a dilated crypt opening was an important indicator of SSA/Ps. However, no studies to date have measured the actual extent of dilatation. Hence, we investigated retrospectively the luminal areas using EC to determine a cutoff value for differentiating SSA/Ps from hyperplastic polyps (HPs). PATIENTS AND METHODS : A total of 101 lesions, including 25 SSA/Ps, 66 HPs, and 10 normal mucosal samples, assessed by an integrated-type EC were collected...
August 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28759612/scheduling-rules-for-patients-with-diabetes-mellitus-that-facilitate-split-dosing-improve-the-quality-of-bowel-preparation-for-colonoscopy
#3
Robert J Hilsden, Ronald Bridges, Catherine Dube, Steven J Heitman, Alaa Rostom
BACKGROUND & AIMS: An adequate bowel preparation for colonoscopy is best achieved by giving the cleansing regimen as a split-dose with the second dose given 4-6 hours before the procedure. This can be difficult to administer to diabetics who are preferentially scheduled for early morning procedures. We examined the impact on bowel preparation quality of scheduling diabetics for mid-morning (9:30 am or later) procedures rather than early morning procedures (7:30-9:00 AM) to facilitate a split-dose preparation...
2017: PloS One
https://www.readbyqxmd.com/read/28752838/sessile-serrated-adenomas-with-dysplasia-morphological-patterns-and-correlations-with-mlh1-immunohistochemistry
#4
Cheng Liu, Neal I Walker, Barbara A Leggett, Vicki Lj Whitehall, Mark L Bettington, Christophe Rosty
Sessile serrated adenomas are the precursor polyp of approximately 20% of colorectal carcinomas. Sessile serrated adenomas with dysplasia are rarely encountered and represent an intermediate step to malignant progression, frequently associated with loss of MLH1 expression. Accurate diagnosis of these lesions is important to facilitate appropriate surveillance, particularly because progression from dysplasia to carcinoma can be rapid. The current World Health Organization classification describes two main patterns of dysplasia occurring in sessile serrated adenomas, namely, serrated and conventional...
July 28, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28723863/factors-associated-with-classification-of-hyperplastic-polyps-as-sessile-serrated-adenomas-polyps-on-morphologic-review
#5
Joseph C Anderson, Mikhail Lisovsky, Mary A Greene, Catherine Hagen, Amitabh Srivastava
BACKGROUND: Distinguishing sessile serrated adenomas/polyp (SSA/P), a subset of serrated polyps, from hyperplastic polyps (HPs) remains a challenge and has surveillance implications. Our goal was to identify clinical and pathologic factors associated with serrated polyps originally read as HPs being reassessed as SSA/Ps versus confirmed as HPs. METHODS: Data were collected from consecutive patients with a right-sided HP and a corresponding comparison group with conventional adenomas between 1993 and 2003...
July 18, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28713060/a-standardized-imaging-protocol-for-the-endoscopic-prediction-of-dysplasia-within-sessile-serrated-polyps-with-video
#6
David J Tate, Mahesh Jayanna, Halim Awadie, Lobke Desomer, Ralph Lee, Stephen J Heitman, Mayenaaz Sidhu, Kathleen Goodrick, Nicholas G Burgess, Hema Mehajan, Duncan McLeod, Michael J Bourke
BACKGROUND AND AIMS: Dysplasia within sessile serrated polyps (SSPs) is difficult to detect, may be mistaken for an adenoma risking incomplete resection of the background serrated tissue, and is strongly implicated in interval cancer after colonoscopy. The use of endoscopic imaging to detect dysplasia within SSP has not been systematically studied. METHODS: Consecutively detected SSP ≥8 mm in size were evaluated using a standardized imaging protocol at a tertiary endoscopy center over 3 years...
July 13, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28712761/detection-diagnosis-and-resection-of-sessile-serrated-adenomas-polyps
#7
Jennifer M Kolb, Roy M Soetikno, Aarti K Rao, Dean Fong, Robert V Rouse, Tonya Kaltenbach
No abstract text is available yet for this article.
July 13, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28706430/case-of-pediatric-traditional-serrated-adenoma-resected-via-endoscopic-submucosal-dissection
#8
Sonoko Kondo, Hirohito Mori, Noriko Nishiyama, Takeo Kondo, Ryuichi Shimono, Hitoshi Okada, Takashi Kusaka
Traditional serrated adenoma (TSA) is a type of serrated polyp of the colorectum and is thought to be a precancerous lesion. There are three types of serrated polyps, namely, hyperplastic polyps, sessile serrated adenomas/polyps, and TSAs. TSA is the least common of the three types and accounts for about 5% of serrated polyps. Here we report a pediatric case of TSA that was successfully resected by endoscopic submucosal dissection (ESD). This rare case report describes a pediatric patient with no family history of colonic polyp who was admitted to our hospital with hematochezia...
June 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28702134/evaluating-the-frequency-of-mlh-1-loss-in-serrated-polyps-of-colon-a-single-center-study-from-southern-iran
#9
Bita Geramizadeh, Nooshin Dindar, Samirasadat Hasheminasab, Tahere Haeidari
AIM: Evaluation of the role of MLH-1 loss in serrated polyps of colon in a population of South of Iran. BACKGROUND: There has been extensive change in classification and pathogenesis of serrated polyps of the colon during the last 10 years. The new classification is mostly based on the knowledge of the molecular pathogenesis and the rate of progression to colorectal cancer in these types of polyps. One of the most common and early lesions in molecular pathogenesis of serrated colorectal cancer is loss of MLH-1...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/28687028/adjunctive-use-of-chromoendoscopy-may-improve-the-diagnostic-performance-of-narrow-band-imaging-for-small-sessile-serrated-adenoma-polyp
#10
Li-Chun Chang, Chia-Hung Tu, Been-Ren Lin, Chia-Tung Shun, Weng-Feng Hsu, Jin-Tung Liang, Hsiu-Po Wang, Ming-Shiang Wu, Han-Mo Chiu
BACKGROUND AND AIMS: Endoscopic diagnosis of sessile serrated adenomas/polyps (SSA/P) is challenging because of their subtle appearance. Narrow-band imaging (NBI) is useful for diagnosis, but its utility with concurrent chromoendoscopy (CE), especially to detect small SSA/P, is unproven. PATIENTS AND METHODS: This prospective study enrolled 367 consecutive patients who underwent screening colonoscopy with the finding of serrated polyps. Patients were divided into derivation and validation cohorts: Diagnostic criteria using different endoscopic modalities were generated by regression analysis in the derivation cohort and were validated in the validation cohort for sensitivity, specificity, and accuracy...
July 7, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28682916/risk-factors-of-missed-colorectal-lesions-after-colonoscopy
#11
Jeonghun Lee, Sung Won Park, You Sun Kim, Kyung Jin Lee, Hyun Sung, Pil Hun Song, Won Jae Yoon, Jeong Seop Moon
Several studies have reported a significant rate of missed colorectal polyps during colonoscopy. This study aimed to determine the variables that affect the miss rate of colorectal polyps.We performed a retrospective observational study of patients who, between January 2007 and December 2014, had undergone a second colonoscopy within 6 months of their first. In all patients, the first colonoscopy constituted a screening or surveillance colonoscopy as part of a health check-up, and the patients were referred to the endoscopic clinic if there were meaningful polyps...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28639142/serrated-polyps-of-colon-and-rectum-a-clinicopathologic-review
#12
REVIEW
Bita Geramizadeh, Scott Robertson
BACKGROUND: In the past decade, there have been significant changes in the classification and nomenclature of colorectal polyps. Previously, only two groups of lesions were widely recognized, the adenoma and the hyperplastic polyp. Adenomas were considered the only precursor of colorectal cancer, and hyperplastic polyps were considered innocent with no malignant potential. However, recent discoveries about molecular pathways of colorectal cancers have significantly changed our understanding of these neoplasms...
June 22, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28627675/distinctive-crypt-shape-in-a-sessile-serrated-adenoma-polyp-distribution-of-ki67-p16ink4a-wnt5a-positive-cells-and-intraepithelial-lymphocytes
#13
Kenji Hisamatsu, Kei Noguchi, Hiroyuki Tomita, Aoi Muto, Natsumi Yamada, Kazuhiro Kobayashi, Akihiro Hirata, Tomohiro Kanayama, Ayumi Niwa, Kazuhisa Ishida, Takayuki Nakashima, Yuichiro Hatano, Natsuko Suzui, Tatsuhiko Miyazaki, Akira Hara
Serrated lesions in the colorectum are currently predominantly classified as hyperplastic polyps (HPs), sessile serrated adenomas/polyps (SSA/Ps), and traditional serrated adenomas (TSAs) according to their morphology. However, the histological morphology and the molecular changes in the serrated lesions are still unclear. We performed immunohistochemistry for Ki67, p16INK4a, and WNT5A in human HPs (n=22), SSA/Ps (n=41), and TSAs (n=19). The distribution of Ki67 and p16INK4a positive cells in TSAs was different from that in HPs and SSA/Ps...
June 15, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28614199/wnt-pathway-gene-mutations-are-associated-with-the-presence-of-dysplasia-in-colorectal-sessile-serrated-adenoma-polyps
#14
Taiki Hashimoto, Satoshi Yamashita, Hiroshi Yoshida, Hirokazu Taniguchi, Toshikazu Ushijima, Tesshi Yamada, Yutaka Saito, Atsushi Ochiai, Shigeki Sekine, Nobuyoshi Hiraoka
Sessile serrated adenoma/polyps (SSA/Ps) are believed to be the major precursor of serrated pathway-derived colorectal carcinomas. To better characterize the process of progression from SSA/Ps to carcinomas, we analyzed 46 SSA/Ps with dysplasia and 45 SSA/Ps without dysplasia using targeted next-generation sequencing and immunohistochemistry. Among the WNT pathway genes analyzed, protein-truncating mutations of RNF43, APC, and ZNRF3 were identified in 23 (50%), 4 (9%), and 3 (7%) SSA/Ps with dysplasia, respectively...
September 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28596985/linked-color-imaging-improves-the-visibility-of-colorectal-polyps-a-video-study
#15
Naohisa Yoshida, Yuji Naito, Takaaki Murakami, Ryohei Hirose, Kiyoshi Ogiso, Yutaka Inada, Osamu Dohi, Kazuhiro Kamada, Kazuhiko Uchiyama, Osamu Handa, Hideyuki Konishi, Kewin Tien Ho Siah, Nobuaki Yagi, Yasuko Fujita, Mitsuo Kishimoto, Akio Yanagisawa, Yoshito Itoh
BACKGROUND/STUDY AIM:  Linked color imaging (LCI) by a laser endoscope (Fujifilm Co, Tokyo, Japan) is a novel narrow band light observation. In this study, we aimed to investigate whether LCI could improve the visibility of colorectal polyps using endoscopic videos. PATIENTS AND METHODS:  We prospectively recorded videos of consecutive polyps 2 - 20 mm in size diagnosed as neoplastic polyps. Three videos, white light (WL), blue laser imaging (BLI)-bright, and LCI, were recorded for each polyp by one expert...
June 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28583826/risk-stratification-for-covert-invasive-cancer-among-patients%C3%A2-referred-for-colonic-endoscopic-mucosal-resection-a%C3%A2-large-multicenter-cohort
#16
Nicholas G Burgess, Luke F Hourigan, Simon A Zanati, Gregor J Brown, Rajvinder Singh, Stephen J Williams, Spiro C Raftopoulos, Donald Ormonde, Alan Moss, Karen Byth, Hema Mahajan, Duncan McLeod, Michael J Bourke
BACKGROUND & AIMS: Among patients with large colorectal sessile polyps or laterally spreading lesions, it is important to identify those at risk for submucosal invasive cancer (SMIC). Lesions with overt endoscopic evidence of SMIC are referred for surgery, although those without these features might still contain SMIC that is not visible on endoscopic inspection (covert SMIC). Lesions with a high covert SMIC risk might be better suited for endoscopic submucosal dissection than for endoscopic mucosal resection (EMR)...
June 2, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28569401/macrophage-inhibitory-cytokine-1-growth-differentiation-factor-15-as-a-predictor-of-colonic-neoplasia
#17
M Danta, D A Barber, H P Zhang, M Lee-Ng, S W L Baumgart, V W W Tsai, Y Husaini, M Saxena, C P Marquis, W Errington, S Kerr, S N Breit, D A Brown
BACKGROUND: Serum macrophage inhibitory cytokine-1 (MIC-1/GDF15) concentration has been associated with colonic adenomas and carcinoma. AIMS: To determine whether circulating MIC-1/GDF15 serum concentrations are higher in the presence of adenomas and whether the level decreases after excision. METHODS: Patients were recruited prospectively from a single centre and stratified into five groups: no polyps (NP); hyperplastic polyps (HP); sessile serrated ademona (SSA); adenomas (AP); and colorectal carcinoma (CRC)...
June 1, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28501592/endoscopic-and-molecular-characterization-of-colorectal-sessile-serrated-adenoma-polyps-with-cytological-dysplasia
#18
Yoshihito Tanaka, Hiro-O Yamano, Eiichiro Yamamoto, Hiro-O Matushita, Hironori Aoki, Kenjiro Yoshikawa, Ryo Takagi, Eiji Harada, Michiko Nakaoka, Yuko Yoshida, Makoto Eizuka, Tamotsu Sugai, Hiromu Suzuki, Hiroshi Nakase
BACKGROUND AND AIMS: Sessile serrated adenoma/polyps (SSA/Ps), which are precursor lesions of colorectal cancer (CRC) with BRAF mutation and the CpG island methylator phenotype (CIMP), develop cytological dysplasia (CD) during the progression of colorectal tumorigenesis. In the present study, we aimed to clarify the endoscopic and molecular signatures of SSA/Ps, with and without CD. METHODS: A series of 208 serrated lesions, including 41 hyperplastic polyps (HPs), 90 SSA/Ps, 33 SSA/Ps with CD and 44 traditional serrated adenomas (TSAs), were observed and resected using magnifying endoscopy...
May 10, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28494577/sessile-serrated-adenomas-how-to-detect-characterize-and-resect
#19
REVIEW
Michael X Ma, Michael J Bourke
Serrated polyps are important contributors to the burden of colorectal cancers (CRC). These lesions were once considered to have no malignant potential, but currently up to 30% of all CRC are recognized to arise from the serrated neoplasia pathway. The primary premalignant lesions are sessile serrated adenomas/polyps (SSA/Ps), although traditional serrated adenomas are relatively uncommon. Compared to conventional adenomas, SSA/Ps are morphologically subtle with indistinct borders, may be difficult to detect endoscopically, are more prevalent than previously thought, are associated with synchronous and metachronous advanced neoplasia, and have a higher risk of incomplete resection...
May 11, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28494511/the-ethnic-distribution-of-sessile-serrated-polyps-in-the-united-states-is-inversely-associated-with-h-pylori-prevalence
#20
Amnon Sonnenberg, Kevin O Turner, Robert M Genta
BACKGROUND: Little is known about the epidemiology of sessile serrated polyps (SSP). Our study was aimed to investigate the influence of H. pylori gastritis and demographic patient characteristics (age, sex, ethnicity) on the prevalence of sessile serrated polyps, using a large national database of patients undergoing bi-directional endoscopy. METHODS: De-identified patient data were extracted from the Miraca Life Sciences electronic database of histopathologic reports...
May 11, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
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