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Sessile serrated polyps

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https://www.readbyqxmd.com/read/29308085/could-mycobacterium-avium-subspecies-paratuberculosis-cause-crohn-s-disease-ulcerative-colitis%C3%A2-and-colorectal-cancer
#1
Ellen S Pierce
Infectious agents are known causes of human cancers. Schistosoma japonicum and Schistosoma mansoni cause a percentage of colorectal cancers in countries where the respective Schistosoma species are prevalent. Colorectal cancer is a complication of ulcerative colitis and colonic Crohn's disease, the two main forms of idiopathic inflammatory bowel disease (IIBD). Mycobacterium avium subspecies paratuberculosis (MAP), the cause of a chronic intestinal disease in domestic and wild ruminants, is one suspected cause of IIBD...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29284484/platform-independent-gene-expression-signature-differentiates-sessile-serrated-adenomas-polyps-and-hyperplastic-polyps-of-the-colon
#2
Yasir Rahmatallah, Magomed Khaidakov, Keith K Lai, Hannah E Goyne, Laura W Lamps, Curt H Hagedorn, Galina Glazko
BACKGROUND: Sessile serrated adenomas/polyps are distinguished from hyperplastic colonic polyps subjectively by their endoscopic appearance and histological morphology. However, hyperplastic and sessile serrated polyps can have overlapping morphological features resulting in sessile serrated polyps diagnosed as hyperplastic. While sessile serrated polyps can progress into colon cancer, hyperplastic polyps have virtually no risk for colon cancer. Objective measures, differentiating these types of polyps would improve cancer prevention and treatment outcome...
December 28, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/29250580/a-prospective-comparison-of-cold-snare-polypectomy-using-traditional-or-dedicated-cold-snares-for-the-resection-of-small-sessile-colorectal-polyps
#3
Jeremy P Dwyer, Jonathan Y C Tan, Paul Urquhart, Robyn Secomb, Catherine Bunn, John Reynolds, Richard La Nauze, William Kemp, Stuart Roberts, Gregor Brown
Background and study aims:  The evidence for efficacy and safety of cold snare polypectomy is limited. The aim of this study was to assess the completeness of resection and safety of cold snare polypectomy, using either traditional or dedicated cold snares. Patients and methods:  This was a prospective, non-randomized study performed at a single tertiary hospital. Adult patients with at least one colorectal polyp (size ≤ 10 mm) removed by cold snare were included...
November 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29233671/endoscopic-detection-rate-of-sessile-serrated-lesions-in-lynch-syndrome-patients-is-comparable-to-an-age-and-gender-matched-control-population-case-control-study-with-expert-pathology-review
#4
Jasper L A Vleugels, Husna Sahin, Yark Hazewinkel, Lianne Koens, Jose G van den Berg, Monique E van Leerdam, Evelien Dekker
BACKGROUND: Carcinogenesis in Lynch syndrome involves fast progression of adenomas to colorectal cancer (CRC) due to microsatellite instability. The role of sessile serrated lesions (SSLs) and the serrated neoplasia pathway in these patients is unknown. The aim of this matched case-control study was to compare endoscopic detection rates and distribution of SSLs in Lynch syndrome patients to a matched control population. METHODS: We collected data of Lynch syndrome patients with a proven germline mutation who underwent colonoscopy between January 2011 and April 2016 in 2 tertiary referral hospitals...
December 9, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29231190/lesions-of-all-types-exist-in-colon-polyps-of-all-sizes
#5
Kevin O Turner, Robert M Genta, Amnon Sonnenberg
OBJECTIVES: Although large polyps are known to harbor more advanced neoplasia than small polyps, the extent of the relationship between size and type is not fully known. The study aim was to establish benchmarks for the prevalence of different histologic polyp types among varying size categories. METHODS: The Miraca Life Sciences Database is an electronic repository of histopathologic patient records from private practices throughout the United States. We extracted the records of 483,998 unique patients who underwent colonoscopy with polypectomy between January 2008 and December 2014...
December 12, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29216529/sessile-serrated-adenoma-polyp-leading-to-acute-appendicitis-with-multiple-pyogenic-liver-abscesses-a-case-report
#6
Koki Sato, Masataka Banshodani, Masahiro Nishihara, Junko Nambu, Yasuo Kawaguchi, Fumio Shimamoto, Kiyohiko Dohi, Keizo Sugino, Hideki Ohdan
INTRODUCTION: Although appendicitis is a common disease, appendicitis concurrent with liver abscesses and sessile serrated adenoma/polyp (SSA/P) is rare. PRESENTATION OF CASE: A 69-year-old man presented with symptoms of abdominal pain and fever. Computed tomography (CT) revealed multiple liver abscesses and an enlarged appendix with a pseudotumoral appearance, which suggested acute appendicitis. In the emergency operation, ileocecal resection was performed for the perforated appendicitis with an inflammatory mass in the ileocecum...
December 2, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29202003/implementation-of-an-optical-diagnosis-strategy-saves-costs-and-does-not-impair-clinical-outcomes-of-a-fecal-immunochemical-test-based-colorectal-cancer-screening-program
#7
Jasper L A Vleugels, Marjolein J E Greuter, Yark Hazewinkel, Veerle M H Coupé, Evelien Dekker
Background and study aims:  In an optical diagnosis strategy, diminutive polyps that are endoscopically characterized with high confidence are removed without histopathological analysis and distal hyperplastic polyps are left in situ. We evaluated the effectiveness and costs of optical diagnosis. Methods:  Using the Adenoma and Serrated pathway to Colorectal CAncer (ASCCA) model, we simulated biennial fecal immunochemical test (FIT) screening in individuals aged 55 - 75 years...
December 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29195676/alcohol-smoking-and-the-risk-of-premalignant-and-malignant-colorectal-neoplasms
#8
REVIEW
Ifewumi O Fagunwa, Maurice B Loughrey, Helen G Coleman
Colorectal cancer (CRC) is the third most common cancer worldwide and has a complex aetiology consisting of environmental and genetic factors. In this review, we evaluate the roles of alcohol and tobacco smoking in colorectal neoplasia. Alcohol intake and tobacco smoking are associated with modest, but significantly, increased risks of CRC, adenomatous and serrated polyps. There is consistent evidence of dose-response relationships for both alcohol and smoking, and risk of these neoplasms. Alcohol and smoking appear to be more strongly associated with colorectal polyp than CRC development, suggesting roles in the initiation of neoplastic growths...
October 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/29169195/wide-field-piecemeal-cold-snare-polypectomy-of-large-sessile-serrated-polyps-without-a-submucosal-injection-is-safe
#9
David J Tate, Halim Awadie, Farzan F Bahin, Lobke Desomer, Ralph Lee, Steven J Heitman, Kathleen Goodrick, Michael J Bourke
Background and study aims Large series suggest endoscopic mucosal resection is safe and effective for the removal of large (≥ 10 mm) sessile serrated polyps (SSPs), but it exposes the patient to the risks of electrocautery, including delayed bleeding. We examined the feasibility and safety of piecemeal cold snare polypectomy (pCSP) for the resection of large SSPs. Methods Sequential large SSPs (10 - 35 mm) without endoscopic evidence of dysplasia referred over 12 months to a tertiary endoscopy center were considered for pCSP...
November 23, 2017: Endoscopy
https://www.readbyqxmd.com/read/29168233/progression-to-invasive-cancer-from-sessile-serrated-adenoma-polyp
#10
Satoshi Kinoshita, Toshihiro Nishizawa, Toshio Uraoka
A 86-year-old female had a positive fecal immunochemical test, and a subsequent colonoscopy revealed a whitish, flat elevated lesion (Paris class IIa) 10 mm in diameter in the ascending colon (Figure 1, A). Biopsy was performed and histology confirmed sessile serrated adenoma/polyp (SSA/P). At 2 years, the lesion changed into a flat elevated lesion with depression (Paris class IIa+IIc) 12 mm in diameter (Figure 1, B). However, she refused endoscopic resection because of older age. At 4 years, the lesion increased to 15 mm in diameter, and the right side of the lesion was reddish (Figure 1, C)...
November 23, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29148927/flat-serrated-polyps-at-ct-colonography-relevance-appearance-and-optimizing-interpretation
#11
David H Kim, Meghan G Lubner, Ashley R Cahoon, B Dustin Pooler, Perry J Pickhardt
Serrated polyps are a recently recognized family of colonic polyps with subgroups that harbor future malignant potential. In the past, the significance of these lesions to the colorectal cancer carcinogenesis pathway was not recognized nor well understood. It is now known that serrated polyps account for approximately one-fourth of all sporadic colorectal cancers. The sessile serrated polyp (SSP) (also known as a sessile serrated adenoma [SSA]) is the main lesion of interest given its prevalence and subtle presentation...
November 17, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29148535/the-role-of-apc-in-wnt-pathway-activation-in-serrated-neoplasia
#12
Jennifer Borowsky, Troy Dumenil, Mark Bettington, Sally-Ann Pearson, Catherine Bond, Lochlan Fennell, Cheng Liu, Diane McKeone, Christophe Rosty, Ian Brown, Neal Walker, Barbara Leggett, Vicki Whitehall
Conventional adenomas are initiated by APC gene mutation that activates the WNT signal. Serrated neoplasia is commonly initiated by BRAF or KRAS mutation. WNT pathway activation may also occur, however, to what extent this is owing to APC mutation is unknown. We examined aberrant nuclear β-catenin immunolocalization as a surrogate for WNT pathway activation and analyzed the entire APC gene coding sequence in serrated and conventional pathway polyps and cancers. WNT pathway activation was a common event in conventional pathway lesions with aberrant nuclear immunolocalization of β-catenin and truncating APC mutations in 90% and 89% of conventional adenomas and 82% and 70% of BRAF wild-type cancers, respectively...
November 17, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29147879/increased-risk-for-colon-polyps-in-patients-with-reflux-disease
#13
Amnon Sonnenberg, Kevin O Turner, Robert M Genta
BACKGROUND: Previous studies have found an increased risk for colonic neoplasm in patients with Barrett's esophagus. It is unknown whether such risk applies similarly to other types of gastroesophageal reflux disease (GERD). AIMS: To test whether GERD represents a risk factor for the occurrence of colon polyps. METHODS: The Miraca Life Sciences Database is a large national electronic repository of histopathologic records of patients distributed throughout the entire USA...
November 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29133196/cold-endoscopic-mucosal-resection-of-large-sessile-serrated-polyps-at-colonoscopy-with-video
#14
Nicholas J Tutticci, David G Hewett
BACKGROUND AND AIMS: The optimal technique for the resection of sessile serrated polyps (SSPs) is unknown, with established limitations and risks with conventional polypectomy. Although cold snare polypectomy is safe, the efficacy of piecemeal resection for large lesions is untested. In this study, we evaluate the safety and efficacy of cold endoscopic mucosal resection (EMR) for large SSPs. METHODS: Patients presenting for elective colonoscopy at an academic endoscopy center with 1 or more SSPs ≥10mm in size were enrolled, excluding those on anticoagulants or antiplatelets other than aspirin...
November 10, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29081443/colonoscopy-examination-requires-a-longer-time-in-patients-with-acromegaly-than-in-other-individuals
#15
Masaya Iwamuro, Miho Yasuda, Kou Hasegawa, Satoshi Fujisawa, Kanako Ogura-Ochi, Yuusaku Sugihara, Keita Harada, Sakiko Hiraoka, Hiroyuki Okada, Fumio Otsuka
This study aimed to determine the prevalence of colorectal neoplasms and to investigate the rate of and time required for cecal intubation in patients with acromegaly. A database search performed at our institution identified 29 patients with acromegaly who underwent colonoscopy. Data regarding the endoscopic, biological, and pathological examinations performed were retrospectively reviewed from the clinical records. Subsequently, the rate of and time required for cecal intubation were investigated in 23 patients with acromegaly and compared with the corresponding data of the control group...
October 28, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29049128/changing-pathological-diagnosis-from-hyperplastic-polyp-to-sessile-serrated-adenoma-systematic-review-and-meta-analysis
#16
Yaron Niv
The WHO published a new classification of colonic polyps in 2010, including the group of serrated polyps, which can be divided into hyperplastic polyps (HP), traditional serrated adenomas, and sessile serrated adenomas (SSA) or polyps. To assess the rate of re-diagnosis of HP to SSA and to look for possible predictors for changing the diagnosis. English Medical literature searches were performed for 'reassessment' OR 'reclassification' AND 'hyperplastic polyp' OR 'sessile serrated adenoma' till 31 January 2017...
October 18, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29043592/factors-associated-with-surveillance-adenoma-and-sessile-serrated-polyp-detection-rates
#17
Jennifer K Maratt, Joseph Dickens, Philip S Schoenfeld, Grace H Elta, Kenya Jackson, Daniel Rizk, Christine Erickson, Stacy B Menees
BACKGROUND: Adenoma detection rate (ADR) and sessile serrated polyp detection rate (SSPDR) data in surveillance colonoscopy are limited. AIMS: Our aim was to determine surveillance ADR and SSPDR and identify associated predictors. METHODS: A retrospective review of subjects who underwent surveillance colonoscopy for adenoma and/or SSP at an academic center was performed. The following exclusion criteria were applied: prior colonoscopy ≤ 3 years, incomplete examination, or another indication for colonoscopy...
December 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28979711/clinical-predictors-for-sessile-serrated-polyposis-syndrome-a-case-control-study
#18
Yang Wu, Alexander Mullin, Alina Stoita
AIM: To compared individuals with serrated polyposis syndrome (SPS) to those with sessile serrated adenoma (SSA) and adenomas in the setting of endoscopists with high adenoma detection rates at a secondary and tertiary academic centre. METHODS: Retrospectively we collated the clinical, endoscopic and histological features of all patients with SPS at St Vincent's public and private hospital in the last 3 years. Patients were identified by searching through 2 pathology databases...
September 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28940106/en-bloc-endoscopic-mucosal-resection-is-equally-effective-for-sessile-serrated-polyps-and-conventional-adenomas
#19
Amol Agarwal, Sidyarth Garimall, Frank I Scott, Nuzhat A Ahmad, Michael L Kochman, Gregory G Ginsberg, Vinay Chandrasekhara
BACKGROUND: Sessile serrated polyps (SSPs) are associated with higher rates of incomplete resection compared to conventional adenomas after traditional snare polypectomy. Outcomes after endoscopic mucosal resection (EMR) are less established. The aim of this study was to evaluate the rate of residual neoplasia at surveillance colonoscopy for SSPs compared to conventional adenomas ≥ 10 mm after en bloc EMR. METHODS: Retrospective cohort study of consecutive patients referred for EMR of a colonic lesion ≥ 10 mm from 2005 to 2013...
September 22, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28929387/distinct-histopathological-characteristics-in-colorectal-submucosal-invasive-carcinoma-arising-in-sessile-serrated-adenoma-polyp-and-conventional-tubular-adenoma
#20
Takashi Murakami, Hiroyuki Mitomi, Takashi Yao, Tsuyoshi Saito, Tomoyoshi Shibuya, Naoto Sakamoto, Taro Osada, Sumio Watanabe
The histopathological characteristics of colorectal submucosal invasive carcinoma arising in sessile serrated adenoma/polyp (SSA/P), a rare malignant tumour, have not yet been fully elucidated. To investigate the features of such, we retrospectively analysed 40 submucosal invasive carcinomas with SSA/P (CA-SSA/P) and compared them to 129 cases of submucosal invasive carcinoma with conventional tubular adenoma (CA-AD). We additionally performed hMLH1 immunostaining. CA-SSA/Ps were significantly smaller than CA-ADs (P < 0...
September 19, 2017: Virchows Archiv: An International Journal of Pathology
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