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Sessile serrated polyps

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https://www.readbyqxmd.com/read/29772067/dna-content-analysis-of-colorectal-serrated-lesions-detects-an-aneuploid-subset-of-inflammatory-bowel-disease-associated-serrated-epithelial-change-and-traditional-serrated-adenomas
#1
Won-Tak Choi, Kwun Wah Wen, Peter S Rabinovitch, Danning Huang, Aras N Mattis, Ryan M Gill
AIMS: Serrated lesions (SLs), including sessile serrated adenoma (SSA) and traditional serrated adenoma (TSA), are important premalignant lesions for colorectal cancer (CRC). Although a small subset of SLs are known to harbor TP53 mutations and Wnt/β-catenin pathway activation, suggesting that they may develop dysplasia or CRC via a 'chromosomal instability (CIN)-like' pathway, it is unclear if aneuploidy (characteristic of conventional adenoma) ever develops in SLs and is associated with development of dysplasia or CRC, in this context...
May 17, 2018: Histopathology
https://www.readbyqxmd.com/read/29747061/serrated-epithelial-colorectal-polyps-hyperplastic-polyps-sessile-serrated-adenomas-with-perineurial-stroma-clinicopathological-and-molecular-analysis-of-a-new-series
#2
Katharina Erlenbach-Wünsch, Michel Bihl, Arndt Hartmann, Gabriel M Groisman, Michael Vieth, Abbas Agaimy
Serrated colorectal fibroblastic polyps (FPs) are rare benign mucosal lesions composed of serrated epithelial crypts separated and distorted by intimately associated bland spindle cell proliferations with perineurial-like phenotype. We herein describe 21 new FPs affecting 10 females and 9 males aged 45 to 80 yrs. (mean, 62 yrs). Lesions originated in the sigmoid colon/rectosigmoid junction (n = 16), rectum (n = 2), and other parts of the colon (n = 3). Most patients had additional synchronous or metachronous polyps: classical adenomas (12 patients), sessile serrated adenoma/SSA (1 patient), hyperplastic polyps/HPs (7 patients), both HPs and adenomas (6 patients) and colorectal cancer (2 patients)...
May 4, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29742770/resection-of-large-sessile-serrated-polyps-by-cold-piecemeal-endoscopic-mucosal-resection-serrated-cold-piecemeal-endoscopic-mucosal-resection-scope
#3
Rajaratnam Rameshshanker, Zacharias Tsiamoulos, Andrew Latchford, Morgan Moorghen, Brian P Saunders
No abstract text is available yet for this article.
May 9, 2018: Endoscopy
https://www.readbyqxmd.com/read/29739023/the-clinical-significance-and-synchronous-polyp-burden-of-large-%C3%A2-20-mm-sessile-serrated-polyps-in-patients-without-serrated-polyposis-syndrome
#4
Lobke Desomer, David J Tate, Mahesh Jayanna, Maria Pellise, Halim Awadie, Nicholas G Burgess, Duncan McLeod, Hema Mahajan, Eric Y T Lee, Stephen J Williams, Michael J Bourke
BACKGROUND:  Sessile serrated polyps (SSPs) are important precursors of colorectal carcinoma and interval cancer. Large SSPs (≥ 20 mm) outside the definition of serrated polyposis syndrome (SPS) have not been studied in comparison with SPS. We aimed to describe the characteristics of patients with large SSPs in this context. METHODS:  Patients with at least one SSP (≥ 20 mm) were eligible. Data from three consecutive colonoscopies were used to compare clinical and endoscopic characteristics in three patient groups: SPS, a solitary large SSP, and patients with at least two SSPs without fulfilling the criteria for SPS (oligo-SSP)...
May 8, 2018: Endoscopy
https://www.readbyqxmd.com/read/29738362/colonic-adenomatous-polyps-involving-submucosal-lymphoglandular-complexes-a-diagnostic-pitfall
#5
Hee Eun Lee, Tsung-Teh Wu, Vishal S Chandan, Michael S Torbenson, Taofic Mounajjed
Lymphoglandular complexes (LGCs) are lymphoid nodules containing intestinal mucosa, present in close apposition to muscularis mucosae or submucosa. Rarely, colorectal adenomas involve submucosal LGCs, simulating invasive adenocarcinoma with associated submucosal lymphoid aggregates, and presenting a diagnostic pitfall. We aimed to identify distinctive histologic features between submucosal LGCs and true invasion. Seven adenomas (tubular/tubulovillous adenomas [n=6], including 4 with high-grade dysplasia and 1 with focal intramucosal adenocarcinoma, and sessile serrated adenoma [n=1]) were in the right (n=5) and left colon (n=2)...
May 4, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29736830/comparison-of-small-versus-large-volume-split-dose-preparation-for-colonoscopy-a-study-of-colonoscopy-outcomes
#6
Hassan Siddiki, Sreya Ravi, Mohanad T Al-Qaisi, Ayman R Fath, Francisco Ramirez, Michael D Crowell, Rahul Pannala, Douglas O Faigel, Suryakanth R Gurudu
BACKGROUND: Split dose bowel preparations (SDP) have superior outcomes for colonoscopy as compared to evening before regimens. However, the association of the actual volume of the SDP to colonoscopy outcome measures has not been well studied. AIMS: Compare adenoma detection rate (ADR), sessile serrated polyp detection rate (SDR), mean bowel cleanse score, and predictors of inadequate exams between small volume SDP and large volume SDP. METHODS: We have conducted a retrospective study in patients undergoing colonoscopy with small volume SDP versus large volume SDP between July 2014 and December 2014...
May 7, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29720120/telomere-length-differences-between-colorectal-polyp-subtypes-a-colonoscopy-based-case-control-study
#7
Sheetal Hardikar, Andrea N Burnett-Hartman, Amanda I Phipps, Melissa P Upton, Lee-Ching Zhu, Polly A Newcomb
BACKGROUND: Short telomeres have been associated with increased risk of many cancers, particularly cancers of the gastrointestinal tract including esophagus and stomach. However, the association between telomere length (TL) and colorectal cancer and its precursors, colorectal polyps, is not clear. METHODS: We investigated the relationship between TL and risk of colorectal polyp subtypes in a colonoscopy-based study in western Washington. Participants were 35-79 year-old enrollees at an integrated health care system, who underwent a colonoscopy between 1998 and 2007 (n = 190), completed a self-administered questionnaire, provided blood samples, and were distinguished as having adenomas, serrated polyps, or as polyp-free controls through a standardized pathology review...
May 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29699379/endoscopic-features-of-mucous-cap-polyps-a-way-to-predict-serrated-polyps
#8
Brian T Moy, Faripour Forouhar, Chia-Ling Kuo, Thomas J Devers
Background/Aims: The aims of the study were to identify whether a mucous-cap predicts the presence of serrated polyps, and to determine whether additional endoscopic findings predict the presence of a sessile serrated adenomas/polyp (SSA/P). Methods: We analyzed 147 mucous-capped polyps with corresponding histology, during 2011-2014. Eight endoscopic features (presence of borders, elevation, rim of debris, location in the colon, size ≥10 mm, varicose vessels, nodularity, and alteration in mucosal folds) of mucous-capped polyps were examined to see if they can predict SSA/Ps...
April 27, 2018: Clinical Endoscopy
https://www.readbyqxmd.com/read/29696479/natural-language-processing-accurately-calculates-adenoma-and-sessile-serrated-polyp-detection-rates
#9
Jennifer Nayor, Lawrence F Borges, Sergey Goryachev, Vivian S Gainer, John R Saltzman
BACKGROUND: ADR is a widely used colonoscopy quality indicator. Calculation of ADR is labor-intensive and cumbersome using current electronic medical databases. Natural language processing (NLP) is a method used to extract meaning from unstructured or free text data. AIMS: (1) To develop and validate an accurate automated process for calculation of adenoma detection rate (ADR) and serrated polyp detection rate (SDR) on data stored in widely used electronic health record systems, specifically Epic electronic health record system, Provation® endoscopy reporting system, and Sunquest PowerPath pathology reporting system...
April 26, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29590112/active-braf-v600e-is-the-key-player-in-generation-of-a-sessile-serrated-polyp-specific-dna-methylation-profile
#10
Somaye Dehghanizadeh, Vahid Khoddami, Timothy L Mosbruger, Sue S Hammoud, Kornelia Edes, Therese S Berry, Michelle Done, Wade S Samowitz, James A DiSario, Daniel G Luba, Randall W Burt, David A Jones
BACKGROUND: Sessile serrated polyps (SSPs) have emerged as important precursors for a large number of sporadic colorectal cancers. They are difficult to detect during colonoscopy due to their flat shape and the excessive amounts of secreted mucin that cover the polyps. The underlying genetic and epigenetic basis for the emergence of SSPs is largely unknown with existing genetic studies confined to a limited number of oncogenes and tumor suppressors. A full characterization of the genetic and epigenetic landscape of SSPs would provide insight into their origin and potentially offer new biomarkers useful for detection of SSPs in stool samples...
2018: PloS One
https://www.readbyqxmd.com/read/29570172/sessile-serrated-adenomas-in-young-patients-may-have-limited-risk-of-malignant-progression
#11
Mark Bettington, Ian Brown, Christophe Rosty, Neal Walker, Cheng Liu, John Croese, Tony Rahman, Sally-Ann Pearson, Diane McKeone, Barbara Leggett, Vicki Whitehall
GOALS: To provide preliminary evidence that sessile serrated adenomas (SSA) are low-risk polyps in young patients. BACKGROUND: SSAs are the dominant polyp of the serrated neoplasia pathway and as such are the precursor of up to 20% of colorectal carcinomas (CRC). Up to 90% of these cancers are expected to harbor a BRAF mutation. SSAs are being diagnosed with increasing frequency in young patients, placing a significant burden on colonoscopic services. Evidence to direct the surveillance intervals for these young patients is not available...
March 21, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29564561/development-and-endoscopic-appearance-of-colorectal-tumors-are-characterized-by-the-expression-profiles-of-mirnas
#12
REVIEW
Yoshihito Nakagawa, Yukihiro Akao, Tomomitsu Tahara, Hiromi Yamashita, Mitsuo Nagasaka, Tomoyuki Shibata, Naoki Ohmiya
Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We previously reported to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. In this report, we focused on colorectal adenoma (tubular or tubulovillous adenoma), or tubular early carcinoma or type 2 adenocarcinoma, familial adenomatous polyposis (FAP), ulcerative colitis-associated tumor (UCAT), and sessile serrated adenoma/polyp (SSA/P)...
March 21, 2018: Medical Molecular Morphology
https://www.readbyqxmd.com/read/29564038/sessile-serrated-adenoma-detection-rate-is-correlated-with-adenoma-detection-rate
#13
Daisuke Ohki, Yosuke Tsuji, Tomohiro Shinozaki, Yoshiki Sakaguchi, Chihiro Minatsuki, Hiroto Kinoshita, Keiko Niimi, Satoshi Ono, Yoku Hayakawa, Shuntaro Yoshida, Atsuo Yamada, Shinya Kodashima, Nobutake Yamamichi, Yoshihiro Hirata, Tetsuo Ushiku, Mitsuhiro Fujishiro, Masashi Fukayama, Kazuhiko Koike
AIM: To investigated the association between adenoma detection rate (ADR) and sessile serrated ADR (SSADR) and significant predictors for sessile serrated adenomas (SSA) detection. METHODS: This study is a retrospective, single-center analysis. Total colonoscopies performed by the gastroenterologists at the University of Tokyo Hospital between January and December 2014 were retrospectively identified. Polyps were classified as low-grade or high-grade adenoma, cancer, SSA, or SSA with cytological dysplasia, and the prevalence of each type of polyp was investigated...
March 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29556334/potential-red-flag-identification-of-colorectal-adenomas-with-wide-field-fluorescence-molecular-endoscopy
#14
Elmire Hartmans, Jolien J J Tjalma, Matthijs D Linssen, Pilar Beatriz Garcia Allende, Marjory Koller, Annelies Jorritsma-Smit, Mariana E Silva de Oliveira Nery, Sjoerd G Elias, Arend Karrenbeld, Elisabeth G E de Vries, Jan H Kleibeuker, Gooitzen M van Dam, Dominic J Robinson, Vasilis Ntziachristos, Wouter B Nagengast
Adenoma miss rates in colonoscopy are unacceptably high, especially for sessile serrated adenomas / polyps (SSA/Ps) and in high-risk populations, such as patients with Lynch syndrome. Detection rates may be improved by fluorescence molecular endoscopy (FME), which allows morphological visualization of lesions with high-definition white-light imaging as well as fluorescence-guided identification of lesions with a specific molecular marker. In a clinical proof-of-principal study, we investigated FME for colorectal adenoma detection, using a fluorescently labelled antibody (bevacizumab-800CW) against vascular endothelial growth factor A (VEGFA), which is highly upregulated in colorectal adenomas...
2018: Theranostics
https://www.readbyqxmd.com/read/29546645/subtypes-of-the-type-ii-pit-pattern-reflect-distinct-molecular-subclasses-in-the-serrated-neoplastic-pathway
#15
Hironori Aoki, Eiichiro Yamamoto, Hiro-O Yamano, Tamotsu Sugai, Tomoaki Kimura, Yoshihito Tanaka, Hiro-O Matsushita, Kenjiro Yoshikawa, Ryo Takagi, Eiji Harada, Michiko Nakaoka, Yuko Yoshida, Taku Harada, Gota Sudo, Makoto Eizuka, Akira Yorozu, Hiroshi Kitajima, Takeshi Niinuma, Masahiro Kai, Masanori Nojima, Hiromu Suzuki, Hiroshi Nakase
BACKGROUND: Colorectal serrated lesions (SLs) are important premalignant lesions whose clinical and biological features are not fully understood. AIMS: We aimed to establish accurate colonoscopic diagnosis and treatment of SLs through evaluation of associations among the morphological, pathological, and molecular characteristics of SLs. METHODS: A total of 388 premalignant and 18 malignant colorectal lesions were studied. Using magnifying colonoscopy, microsurface structures were assessed based on Kudo's pit pattern classification system, and the Type II pit pattern was subcategorized into classical Type II, Type II-Open (Type II-O) and Type II-Long (Type II-L)...
March 15, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29542866/clinicopathological-features-of-advanced-colorectal-serrated-lesions-a-single-center-study-in-china
#16
Tian Yu Liu, Duo Chen Jin, Samiullah Khan, Xue Chen, Tao Shi, Wen Xiao Dong, Yan Rong Qi, Zi Xuan Guo, Bang Mao Wang, Hai Long Cao
OBJECTIVE: A growing body of evidence indicates that patients with colorectal serrated lesions, especially advanced serrated lesions (ASLs), are at risk of subsequent malignancy. This study aimed to analyze the clinicopathological features of ASLs and the association between ASLs and synchronous advanced colorectal neoplasia (sACN) in a single center of China. METHODS: A retrospective cross-sectional study of consecutive symptomatic patients and healthy individuals who underwent colonoscopy between January 2010 and March 2016 was performed...
April 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29539651/linked-color-imaging-reduces-the-miss-rate-of-neoplastic-lesions-in-the-right-colon-a-randomized-tandem-colonoscopy-study
#17
Silvia Paggi, Giuseppe Mogavero, Arnaldo Amato, Emanuele Rondonotti, Alida Andrealli, Gianni Imperiali, Nicoletta Lenoci, Giovanna Mandelli, Natalia Terreni, Francesco Simone Conforti, Dario Conte, Giancarlo Spinzi, Franco Radaelli
BACKGROUND:  Linked color imaging (LCI) is a newly developed image-enhancing endoscopy technology that provides bright endoscopic images and increases color contrast. We investigated whether LCI improves the detection of neoplastic lesions in the right colon when compared with high definition white-light imaging (WLI). METHODS:  Consecutive patients undergoing colonoscopy were randomized (1:1) after cecal intubation into right colon inspection at first pass by LCI or by WLI...
April 2018: Endoscopy
https://www.readbyqxmd.com/read/29527554/linked-color-imaging-enhances-endoscopic-detection-of-sessile-serrated-adenoma-polyps
#18
Daisaku Fujimoto, Naoki Muguruma, Koichi Okamoto, Yasuteru Fujino, Kaizo Kagemoto, Yasuyuki Okada, Yoshifumi Takaoka, Yasuhiro Mitsui, Shinji Kitamura, Tetsuo Kimura, Hiroshi Miyamoto, Yoshimi Bando, Tomoko Sonoda, Tetsuji Takayama
Background and study aims:  Although new image-enhanced endoscopy (IEE) technologies such as blue laser imaging (BLI), BLI-bright, and linked color imaging (LCI) have been developed, their utility for the detection of sessile serrated adenoma/polyps (SSA/Ps) is still unclear. This study aimed to evaluate the utility of BLI, BLI-bright, and LCI for SSA/P detection in still image examinations and in a prospective randomized controlled trial (RCT). Patients and methods:  A group of 6 expert and non-expert endoscopists read 200 endoscopic still images containing SSA/P lesions using white light image (WLI), BLI, BLI-bright, and LCI...
March 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29516270/resection-depth-and-layer-of-cold-snare-polypectomy-versus-endoscopic-mucosal-resection
#19
Akihiro Ito, Tomoaki Suga, Hiroyoshi Ota, Nobuyuki Tateiwa, Akihiro Matsumoto, Eiji Tanaka
BACKGROUND: Cold snare polypectomy (CSP) has not undergone sufficient histopathological evaluation. This study aimed to clarify the histopathological features of CSP specimens, including resection depth and layer, as compared with endoscopic mucosal resection (EMR). METHODS: Polyps were recruited retrospectively. Sessile, semi-pedunculated, and 0-IIa polyps of ≤ 9 mm were selected by propensity score matching and classified as either a complete resection or one with an unevaluable/positive (X/+) margin...
March 7, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29496722/calcium-and-vitamin-d-supplementation-and-increased-risk-of-serrated-polyps-results-from-a-randomised-clinical-trial
#20
Seth D Crockett, Elizabeth L Barry, Leila A Mott, Dennis J Ahnen, Douglas J Robertson, Joseph C Anderson, Kristen Wallace, Carol A Burke, Robert S Bresalier, Jane C Figueiredo, Dale C Snover, John A Baron
OBJECTIVE: Serrated lesions such as sessile serrated adenomas or polyps (SSA/Ps) are important colorectal cancer precursors, but aetiological factors for these lesions are largely unknown. We aimed to determine the effects of calcium and vitamin D supplementation on the incidence of serrated polyps (SPs) in general and hyperplastic polyps and SSA/Ps specifically. DESIGN: Participants with one or more adenoma at baseline were randomised to receive 1200 mg/day of elemental calcium, 1000 IU/day of vitamin D3 , both or neither agent...
March 1, 2018: Gut
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