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https://www.readbyqxmd.com/read/29684789/bipedal-hopping-timed-to-a-metronome-to-detect-impairments-in-anticipatory-motor-control-in-people-with-mild-multiple-sclerosis
#1
Megan C Kirkland, Alice Chen, Matthew B Downer, Brett J Holloway, Elizabeth M Wallack, Evan J Lockyer, Natasha C M Buckle, Courtney L Abbott, Michelle Ploughman
BACKGROUND: People with mild multiple sclerosis (MS) often report subtle deficits in balance and cognition but display no measurable impairment on clinical assessments. We examined whether hopping to a metronome beat had the potential to detect anticipatory motor control deficits among people with mild MS (Expanded Disability Status Scale ≤ 3.5). METHODS: Participants with MS (n = 13), matched controls (n = 9), and elderly subjects (n = 13) completed tests of cognition (Montreal Cognitive Assessment (MoCA)) and motor performance (Timed 25 Foot Walk Test (T25FWT))...
April 13, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29684506/age-related-impairment-of-hand-movement-perception-based-on-muscle-proprioception-and-touch
#2
C Landelle, A El Ahmadi, A Kavounoudias
Impairment in fine hand motor dexterity is well established in older people, yet little is known, about the impaired perception of hand movement in the elderly. Only an age-related increase in movement detection threshold has been reported. Perception of hand movements relies on multiple sensory information, including touch and muscle proprioception. The present study aims to investigate to what extent aging impacts the ability to perceive hand movements accurately and whether this impairment is from a muscle proprioceptive and/or tactile origin...
April 20, 2018: Neuroscience
https://www.readbyqxmd.com/read/29683094/role-of-inflammatory-markers-in-elderly-type-2-diabetic-patients-with-mild-cognitive-impairment
#3
Salwa S Hosny, Ahmed M Bahaaeldin, Mohamed S Khater, Meram M Bekhet, Hayam A Hebah, Ghada A Hasanin
BACKGROUND: Type 2 diabetes (T2DM) is a risk factor for Alzheimer's disease and mild cognitive impairment. The etiology of cognitive impairment in people with T2DM is uncertain but, chronic hyperglycemia, cerebral micro vascular disease, severe hypoglycemia, and increased prevalence of macro vascular disease are implicated. OBJECTIVES: to determine the serum levels of soluble vascular adhesion molecule (sVCAM-1) and highly sensitive C-reactive protein (hs-CRP) in elderly type 2 diabetics with mild cognitive impairment (MCI)...
April 22, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29683042/factors-affecting-continuation-of-clean-intermittent-catheterisation-in-people-with-multiple-sclerosis-results-of-the-cosmos-mixed-methods-study
#4
Doreen McClurg, Carol Bugge, Andrew Elders, Tasneem Irshad, Suzanne Hagen, Katherine N Moore, Brian Buckley, Mandy Fader
BACKGROUND: Clean intermittent catheterisation (CIC) is often recommended for people with multiple sclerosis (MS). OBJECTIVE: To determine the variables that affect continuation or discontinuation of the use of CIC. METHODS: A three-part mixed-method study (prospective longitudinal cohort ( n = 56), longitudinal qualitative interviews ( n = 20) and retrospective survey ( n = 456)) was undertaken, which identified the variables that influenced CIC continuation/discontinuation...
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29683033/needs-in-service-provision-for-oral-health-care-in-older-people-a-comparison-between-greater-manchester-united-kingdom-and-utrecht-the-netherlands
#5
Babette Everaars, Katarina Jerković-Ćosić, Gert-Jan van der Putten, Ian A Pretty, Paul Brocklehurst
Retaining natural teeth for longer, together with increasing care dependency in the elderly, has the potential to hamper adequate oral self-care and service provision. The aim of this qualitative study was to compare and contrast views from a multi-stakeholder perspective on the future priorities for oral health care services of older people in the United Kingdom and the Netherlands. A participatory setting partnership was undertaken with 4 key stakeholder groups in the United Kingdom and the Netherlands. A final consensus group considered collective responses...
January 1, 2018: International Journal of Health Services: Planning, Administration, Evaluation
https://www.readbyqxmd.com/read/29682843/chronic-condition-self-management-support-for-aboriginal-people-adapting-tools-and-training
#6
Malcolm Battersby, Sharon Lawn, Inge Kowanko, Sue Bertossa, Coral Trowbridge, Raylene Liddicoat
PROBLEM: Chronic conditions are major health problems for Australian Aboriginal people. Self-management programs can improve health outcomes. However, few health workers are skilled in self-management support and existing programs are not always appropriate in Australian Aboriginal contexts. DESIGN: The goal was to increase the capacity of the Australian health workforce to support Australian Aboriginal people to self-manage their chronic conditions by adapting the Flinders Program of chronic condition self-management support for Australian Aboriginal clients and develop and deliver training for health professionals to implement the program...
April 22, 2018: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/29682215/oxidative-stress-role-of-physical-exercise-and-antioxidant-nutraceuticals-in-adulthood-and-aging
#7
REVIEW
Carolina Simioni, Giorgio Zauli, Alberto M Martelli, Marco Vitale, Gianni Sacchetti, Arianna Gonelli, Luca M Neri
Physical exercise is considered to be one of the beneficial factors of a proper lifestyle and is nowadays seen as an indispensable element for good health, able to lower the risk of disorders of the cardiovascular, endocrine and osteomuscular apparatus, immune system diseases and the onset of potential neoplasms. A moderate and programmed physical exercise has often been reported to be therapeutic both in the adulthood and in aging, since capable to promote fitness. Regular exercise alleviates the negative effects caused by free radicals and offers many health benefits, including reduced risk of all-cause mortality, sarcopenia in the skeletal muscle, chronic disease, and premature death in elderly people...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29679895/ingredientes-farmac%C3%A3-uticos-activos-potencialmente-inapropiados-en-adultos-mayores-lista-ifaspiam-panel-de-consenso-argentino
#8
Marta M Marzi, Miryam S Pires, Nora B Quaglia
OBJECTIVES: To perform a list agreed by Argentinean experts and adapted to the local context containing potentially inappropriate (PI) medications in old people (OP) usingthe Delphi consensus technique optimized for this subject. METHODS: A preliminary list of potentially inappropriate medications (PIM) was drawn up based on foreign PIM lists and a selective search in the scientific literature. The iterative Delphi process was used to submit the active pharmaceutical ingredients (APIs) of the preliminary PIM list to the panel of Argentinean experts...
April 18, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29679658/effective-multicomponent-interventions-in-comparison-to-active-control-and-no-interventions-on-physical-capacity-cognitive-function-and-instrumental-activities-of-daily-living-in-elderly-people-with-and-without-mild-impaired-cognition-a-systematic-review-and
#9
REVIEW
Marina Bruderer-Hofstetter, Anne-Kathrin Rausch-Osthoff, André Meichtry, Thomas Münzer, Karin Niedermann
Multicomponent interventions (MCT) combine physical exercises and cognitive training and seem to be most effective in improving cognition in elderly people. However, literature is inconclusive if MCTs are superior to active comparison interventions, if delivery modes matter, and if people can transfer achieved effects to instrumental activities of daily living (IADL). This network meta-analysis aimed to a) identify MCTs that were effective on physical capacity and/or cognitive function and able to transfer these effects into IADL in elderly people with normal cognition (NC) and mild cognitive impairment (MCI); b) provide a rating on the best interventions per outcome; c) evaluate MCTs' mode of delivery...
April 18, 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/29678666/biochemical-deficits-and-cognitive-decline-in-brain-aging-intervention-by-dietary-supplements
#10
REVIEW
Jit Poddar, Munmun Pradhan, Gargi Ganguly, Sasanka Chakrabarti
The aging of brain in the absence of neurodegenerative diseases, usually called non-pathological brain aging or normal cognitive aging, is characterized by an impairment of memory and cognitive functions. The underlying cellular and molecular changes in the aging brain that include oxidative damage, mitochondrial impairment, changes in glucose-energy metabolism and neuroinflammation have been reported widely from animal experiments and human studies. The cognitive deficit of non-pathological brain aging is the resultant of such inter-dependent and reinforcing molecular pathologies which have striking similarities with those operating in Alzheimer's disease which causes progressive, irreversible and a devastating form of dementia and cognitive decline in the elderly people...
April 17, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29678270/multi-directional-reach-test-in-south-asian-children-normative-reference-scores-from-5-year-to-12-years-old
#11
Kavita Sharma, Asir John Samuel, Divya Midha, Vencita Priyanka Aranha, Kanimozhi Narkeesh, Narkeesh Arumugam
Multi-directional reach test (MRT) emerged as a valid and reliable assessment tool for balance evaluation among elderly. The normative reference scores have been established in adults and elderly people, but they were not yet established for children. Hence, we aimed at establishing the normative reference scores of MRT among the school going children aged between 5 and 12 years. Children (N = 194; 124 males, 70 females) were recruited by the stratified random sampling for the normative study. MRT was performed by the custom made, multi-directional reach estimator...
March 27, 2018: Homo: Internationale Zeitschrift Für die Vergleichende Forschung Am Menschen
https://www.readbyqxmd.com/read/29678164/unmet-healthcare-needs-of-elderly-people-in-korea
#12
Yoon-Sook Kim, Jongmin Lee, Yeonsil Moon, Kyoung Jin Kim, Kunsei Lee, Jaekyung Choi, Seol-Heui Han
BACKGROUND: Elderly people often have more complicated healthcare needs than younger adults due to additional functional decline, physical illness, and psychosocial needs. Unmet healthcare needs increase illness severity, complications, and mortality. Despite this, research on the unmet healthcare needs of elderly people is limited in Korea. This study analysed the effect of functional deterioration related to aging on unmet healthcare needs based on the Korea Health Panel Study. METHODS: This cross-sectional study used data from the 2011-2013 survey of 8666 baseline participants aged 65 years and older...
April 20, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29678039/topic-repetition-in-conversations-on-different-days-as-a-sign-of-dementia
#13
Kaoru Shinkawa, Yasunori Yamada
Detecting early signs of dementia in everyday situations becomes more and more important in a rapidly aging society. Language dysfunctions are recognized as the prominent signs of dementia. Previous computational studies characterized these language dysfunctions by using acoustic and linguistic features for detecting dementia. However, they mainly investigated language dysfunctions collected from patients during neuropsychological tests. Language dysfunctions observed during regular conversations in everyday situations received little attention...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677930/a-predictive-model-for-acute-admission-in-aged-population
#14
Marjan Mansourvar, Karen Andersen-Ranberg, Christian Nøhr, Uffe Kock Wiil
Acute hospital admission among the elderly population is very common and have a high impact on the health services and the community, as well as on the individuals. Several studies have focused on the possible risk factors, however, predicting who is at risk for acute hospitalization associated with disease and symptoms is still an open research question. In this study, we investigate the use of machine learning algorithms for predicting acute admission in older people based on admission data from individual citizens 70 years and older who were hospitalized in the acute medical unit of Svendborg Hospital in Denmark...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677664/age-induced-changes-in-the-lower-limb-muscle-activities-during-uphill-walking-at-steep-grades
#15
Sonja Th Kwee-Meier, Alexander Mertens, Sabina Jeschke
BACKGROUND: Uphill walking is particularly challenging for elderly persons. However, there is a lack of age-differentiated studies investigating the underlying differences in muscle activation when walking on sloped surfaces. These studies are needed, e.g., for planning of evacuations of large modern cruise ships with long walking distances on often inclined surfaces. METHODS: An age-differentiated, gender-balanced study with 26 young (20-30 years) and 26 elderly people (60-77 years) was therefore conducted, investigating uphill walking at 7° and at 14° contrasted to level walking on a treadmill...
April 12, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29676502/indignity-and-old-age
#16
John-Stewart Gordon
This article examines the nature of human dignity against the background of old age and introduces the novel idea of treating human dignity as a formal principle related to the more foundational notion of indignity. The discussion starts with the objection that the notion of human dignity can be used to justify contrary positions and is therefore inconclusive. This pitfall can be averted by appealing to the notion of indignity rather than dignity in one's moral reasoning and decision-making. Cases of indignity are more primary and indicate the violation of the very core of a human being...
May 2018: Bioethics
https://www.readbyqxmd.com/read/29676499/responsibility-and-age-related-dementia
#17
Petr Frantik
This article identifies the assumption of responsibility as a basic need of human beings and applies the concept specifically to older people with dementia or Alzheimer's disease. It suggests a two-level concept of responsibility, based on the approach of discourse ethicist Karl-Otto Apel, as a promising approach to recognizing human diversity while at the same time respecting people's equal rights to participate in discourse. This concept can serve as a theoretical starting point for the construction of individually adapted types of responsibility...
May 2018: Bioethics
https://www.readbyqxmd.com/read/29676498/are-older-people-a-vulnerable-group-philosophical-and-bioethical-perspectives-on-ageing-and-vulnerability
#18
Claudia Bozzaro, Joachim Boldt, Mark Schweda
The elderly are often considered a vulnerable group in public and academic bioethical debates and regulations. In this paper, we examine and challenge this assumption and its ethical implications. We begin by systematically delineating the different concepts of vulnerability commonly used in bioethics, before then examining whether these concepts can be applied to old age. We argue that old age should not, in and of itself, be used as a marker of vulnerability, since ageing is a process that can develop in a variety of different ways and is not always associated with particular experiences of vulnerability...
May 2018: Bioethics
https://www.readbyqxmd.com/read/29676293/association-between-polymorphism-of-tumor-necrosis-factor-alpha-tnf%C3%AE-in-the-region-308-g-a-with-tinnitus-in-the-elderly-with-a-history-of-occupational-noise-exposure
#19
Luciana L M Marchiori, Ana C M Dias, Alyne S Gonçalvez, Regina C Poly-Frederico, Marcelo Y Doi
Context: Tinnitus is a common disorder that occurs frequently across all strata of population and has an important health concern and is often associated with different forms of the hearing loss of varying severity. Aims: To investigate the association between the polymorphism of tumor necrosis factor alpha (TNFα) in the region -308 G/A with the susceptibility to tinnitus in individuals with the history of exposure to occupational noise. Settings and Design: This was a cross-sectional study with a sample of 179 independent elderly people above 60 years of age...
March 2018: Noise & Health
https://www.readbyqxmd.com/read/29676170/discovery-of-novel-dual-acetylcholinesterase-inhibitors-with-antifibrillogenic-activity-related-to-alzheimer-s-disease
#20
Jonathan R de Almeida, Micheli Figueiro, Wanda Pereira Almeida, Carlos Henrique Tomich de Paula da Silva
AIM: Alzheimer's disease is a progressive and neurodegenerative disorder of the CNS, affecting elderly people. The current pharmacological approach is based on the improvement of cholinergic neurotransmission by inhibiting acetylcholinesterase (AChE) with AChE inhibitors. The disease is also characterized by the accelerated accumulation of β-amyloid plaques around neurons. Furthermore, in vitro studies revealed that AChE can induce β-amyloid peptide (Aβ) aggregation. METHODOLOGY: Computer-aided molecular design by virtual screening was here employed to discover novel potential AChE inhibitors, with antifibrillogenic properties, in other words, inhibiting Aβ aggregation...
April 20, 2018: Future Medicinal Chemistry
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