Jonathan P Piccini, Anders Ahlsson, Paul Dorian, A Marc Gillinov, Peter R Kowey, Michael J Mack, Carmelo A Milano, Nicolas Noiseux, Louis P Perrault, William Ryan, Jonathan S Steinberg, Pierre Voisine, Nathan H Waldron, Kevin J Gleason, Wilson Titanji, Richard D Leaback, Alexandra O'Sullivan, William G Ferguson, Stefano Benussi
BACKGROUND: Postoperative atrial fibrillation (POAF) is associated with increased morbidity and mortality. Epicardial injection of botulinum toxin may suppress POAF. OBJECTIVES: This study sought to assess the safety and efficacy of AGN-151607 for the prevention of POAF after cardiac surgery. METHODS: This phase 2, randomized, placebo-controlled trial assessed the safety and efficacy of AGN-151607, 125 U and 250 U vs placebo (1:1:1), for the prevention of POAF after cardiac surgery...
March 25, 2024: JACC. Clinical Electrophysiology