Yuzhi Sun, Renwang Sheng, Zhicheng Cao, Chuanquan Liu, Jiaxiang Li, Po Zhang, Yan Du, Qingyun Mo, Qingqiang Yao, Jialin Chen, Wei Zhang
Myotendinous junction (MTJ) injuries are prevalent in clinical practice, yet the treatment approaches are limited to surgical suturing and conservative therapy, exhibiting a high recurrence rate. Current research on MTJ tissue engineering is scarce and lacks in vivo evaluation of repair efficacy. Here, we developed a three-dimensional-printed bioactive fiber-reinforced hydrogel containing mesenchymal stem cells (MSCs) and Klotho for structural and functional MTJ regeneration. In a rat MTJ defect model, the bioactive fiber-reinforced hydrogel promoted the structural restoration of muscle, tendon, and muscle-tendon interface and enhanced the functional recovery of injured MTJ...
April 26, 2024: Science Advances