Gabriel Torres Iglesias, Mireya Fernández-Fournier, Lucía Botella, Dolores Piniella-Alcalde, Fernando Laso-García, Mari Carmen Gómez-de Frutos, Beatriz Chamorro, Inmaculada Puertas, Antonio Tallón, Blanca Fuentes, María Alonso de Leciñana, Elisa Alonso-López, Susana B Bravo, María Eugenia Miranda-Carús, Ana Montero-Calle, Rodrigo Barderas, Exuperio Diez-Tejedor, María Gutiérrez-Fernández, Laura Otero-Ortega
BACKGROUND: Multiple sclerosis (MS) is an immune-mediated central nervous system disease whose course is unpredictable. Finding biomarkers that help to better comprehend the disease's pathogenesis is crucial for supporting clinical decision-making. Blood extracellular vesicles (EVs) are membrane-bound particles secreted by all cell types that contain information on the disease's pathological processes. PURPOSE: To identify the immune and nervous system-derived EV profile from blood that could have a specific role as biomarker in MS and assess its possible correlation with disease state...
July 3, 2023: Brain, Behavior, and Immunity