keyword
MENU ▼
Read by QxMD icon Read
search

Gelsolin

keyword
https://www.readbyqxmd.com/read/27879149/increasing-amount-of-amyloid-are-associated-with-the-severity-of-clinical-features-in-hereditary-gelsolin-agel-amyloidosis
#1
Tiia Pihlamaa, Sinikka Suominen, Sari Kiuru-Enari, Maarit Tanskanen
BACKGROUND: Patients with hereditary gelsolin (AGel) amyloidosis (HGA) present with hanging skin (cutis laxa) and bilateral cranial neuropathy, and require symptomatic plastic surgery. Our clinical observation of tissue fragility prompted us to design a prospective study. METHODS: Twenty-nine patients with HGA undergoing surgery were interviewed and clinically examined. The height and thickness of skin folds in standard anatomical localizations were measured. The presence and distribution of amyloid in skin samples were analyzed using Congo red staining and immunohistochemistry using antibodies against gelsolin amyloid (AGel) subunit...
December 2016: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/27863071/the-putative-involvement-of-actin-binding-proteins-and-cytoskeleton-proteins-in-pathological-mechanisms-of-ketamine-cystitis-revealed-by-a-prospective-pilot-study-using-proteomic-approaches
#2
Hsueh-Hui Yang, Wei-Jun Zhai, Hann-Chorng Kuo
PURPOSE: Ketamine Cystitis (KC) among chronic ketamine young abusers has increased dramatically and it has brought attention for Urologists. The underlying pathophysiological mechanism(s) of KC is still unclear. Therefore, the purpose of this study was to elucidate the possible pathophysiological mechanism(s) of KC through proteomic techniques. EXPERIMENTAL DESIGN: Bladder tissues were obtained from 7 patients with KC, 7 patients with interstitial cystitis/bladder pain syndrome, and 5 control subjects who underwent videourodynamic study followed by augmentation enterocystoplasty to increase bladder capacity...
November 10, 2016: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/27823961/antagonistic-sepsis-markers-serum-gelsolin-and-actin-gelsolin-ratio
#3
Zoltán Horváth-Szalai, Péter Kustán, Diána Mühl, Andrea Ludány, Beáta Bugyi, Tamás Kőszegi
OBJECTIVES: For appropriate sepsis care, prognostic laboratory markers are mandatory. The aim of our study was to evaluate the predictive value of serum actin, gelsolin and the recently defined actin/gelsolin ratio during sepsis by comparison it to classical clinical and inflammatory laboratory parameters. DESIGN & METHODS: We analyzed sera of severe septic (n=32) and SIRS (n=12) patients for 5days. Ophthalmologic patients (n=27) served as controls. Besides serum actin, gelsolin and actin/gelsolin ratios classical laboratory parameters (WBC count, serum procalcitonin, hsCRP) and clinical scores (APACHE II, SAPS II, SOFA), were also assessed...
November 4, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27801591/detection-of-proteome-changes-in-human-colon-cancer-induced-by-cell-surface-binding-of-growth-inhibitory-human-galectin-4-using-quantitative-silac-based-proteomics
#4
Malwina Michalak, Uwe Warnken, Sabine André, Martina Schnölzer, Hans-Joachim Gabius, Juergen Kopitz
Endogenous lectins have the capacity to translate glycan-encoded information on the cell surface into effects on cell growth. As test case to examine changes in protein presence associated with tumor growth inhibition, we applied SILAC-based proteomics on human colon carcinoma cells treated with galectin-4 (Gal-4). The five tested lines LS 180, Vaco 432, Colo 205, CX 1 and HCT 116 responded with differentiation and reduced proliferation to Gal-4 binding. In proteomic analysis (mass spectral data deposited with PRIDE - PXD003489), 2654 proteins were quantified: 190 down- and 115 up-regulated (>2-fold)...
November 1, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27798885/%C3%AE-catenin-expression-regulates-cell-migration-of-human-colonic-adenocarcinoma-cells-through-gelsolin
#5
Dagmara Baczynska, Izabela Bombik, Maria Malicka-Błaszkiewicz
BACKGROUND/AIM: β-Catenin is one of the key players in colonic carcinogenesis. Being part of the E-cadherin complex, it regulates cell-cell adhesion and the migratory ability of cells. However, the role of nuclear β-catenin in the cell migration process is poorly understood. Gelsolin is one of the most abundant actin-binding proteins, and is implicated in tumour cell motility and invasiveness. The aim of the present study was to evaluate the potential association between expression of β-catenin and gelsolin, and their influence on the migration ability of colon adenocarcinoma LS180 cells...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27742487/pathophysiological-aldosterone-levels-modify-the-secretory-activity-of-cardiac-progenitor-cells
#6
Kristin Wenzel, Rasmita Samal, Elke Hammer, Vishnu M Dhople, Stefan Gross, Uwe Völker, Stephan B Felix, Stephanie Könemann
Cardiac progenitor cells (CPCs) trigger regenerative processes via paracrine mechanisms in response to changes in their environment. In the present study we explored alterations in the secretory activity of CPCs induced by raised aldosterone levels symptomatic for heart failure. The cytokine profile of the supernatant of CPCs that were treated with the mineralocorticoid showed an induction of interleukin-6 secretion. Mass spectrometric analyses revealed an increase in the abundance of secreted proteins associated with regeneration and cell migration like gelsolin and galectin-1...
October 12, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27724924/mir-9-is-overexpressed-in-spontaneous-canine-osteosarcoma-and-promotes-a-metastatic-phenotype-including-invasion-and-migration-in-osteoblasts-and-osteosarcoma-cell-lines
#7
Joelle M Fenger, Ryan D Roberts, O Hans Iwenofu, Misty D Bear, Xiaoli Zhang, Jason I Couto, Jaime F Modiano, William C Kisseberth, Cheryl A London
BACKGROUND: MicroRNAs (miRNAs) regulate the expression of networks of genes and their dysregulation is well documented in human malignancies; however, limited information exists regarding the impact of miRNAs on the development and progression of osteosarcoma (OS). Canine OS exhibits clinical and molecular features that closely resemble the corresponding human disease and it is considered a well-established spontaneous animal model to study OS biology. The purpose of this study was to investigate miRNA dysregulation in canine OS...
October 10, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27700141/plasma-gelsolin-level-in-hiv-1-infected-patients-an-indicator-of-disease-severity
#8
Kislay Kumar Sinha, Nagesh Peddada, Pravin Kumar Jha, Anshul Mishra, Krishna Pandey, Vidya Nand Ravi Das, Fnu Ashish, Pradeep Das
INTRODUCTION: Plasma gelsolin (pGSN) is a multi-functional protein involved mainly in severing and clearing of actin filaments. Its level correlates with inflammation and several diseases making it potential biomarker of diagnostic and prognostic values. The pGSN level in groups of treated and untreated HIV-1 infected Indian patients is investigated in this study. OBJECTIVE: This study aims at investigating the levels of plasma gelsolin in HIV-1 infected patients across different age, sex, severity of disease and treatment status...
October 4, 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27685836/immune-complexome-analysis-reveals-the-specific-and-frequent-presence-of-immune-complex-antigens-in-lung-cancer-patients-a-pilot-study
#9
Kaname Ohyama, Haruka Yoshimi, Nozomi Aibara, Yoichi Nakamura, Yasuyoshi Miyata, Hideki Sakai, Fumihiko Fujita, Yoshitaka Imaizumi, Anil K Chauhan, Naoya Kishikawa, Naotaka Kuroda
Cancer immunotherapies such as antibodies targeting T cell checkpoints, or adaptive tumor-infiltrating lymphocyte (TIL) transfer, have been developed to boost the endogenous immune response against human malignancies. However, activation of T cells by such antibodies can lead to the risk of autoimmune diseases. Also, the selection of tumor-reactive T cells for TIL relies on information regarding mutated antigens in tumors and does not reflect other factors involved in protein antigenicity. It is therefore essential to engineer therapeutic interventions by which T cell reactivity against tumor cells is selectively enhanced (i...
January 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27633054/molecular-basis-of-a-novel-renal-amyloidosis-due-to-n184k-gelsolin-variant
#10
Francesco Bonì, Mario Milani, Riccardo Porcari, Alberto Barbiroli, Stefano Ricagno, Matteo de Rosa
Mutations in gelsolin are responsible for a systemic amyloidosis first described in 1969. Until recently, the disease was associated with two substitutions of the same residue, leading to the loss of the calcium binding site. Novel interest arose in 2014 when the N184K variant of the protein was identified as the etiological agent of a novel kidney-localized amyloidosis. Here we provide a first rationale for N184K pathogenicity. We show that the mutation induces a destabilization of gelsolin second domain, without compromising its calcium binding capacity...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27627876/gelsolin-role-in-microapocrine-secretion
#11
W Silva, A F Ribeiro, M C P Silva, W R Terra, C Ferreira
A role of gelsolin in opening the way along the microvilli for secretory vesicles during microapocrine secretion is proposed here. Data obtained with different techniques showed that many digestive enzymes are released by microapocrine secretion in insects. Proteins that might be involved in the machinery of microapocrine secretion were selected from our transcriptomes and literature searches. The proteins were annexin, Complex actin-related proteins 2 and 3 (ARP 2/3) cofilin, fimbrin, gelsolin 1, gelsolin 2, moesin, myosin 1, myosin 6, protein disulphide isomerase 1 (PDI 1), PDI 2 and profilin...
December 2016: Insect Molecular Biology
https://www.readbyqxmd.com/read/27627778/gelsolin-in-onychophora-and-tardigrada-with-notes-on-its-variability-in-the-ecdysozoa
#12
Prasath Thiruketheeswaran, Hartmut Greven, Jochen D'Haese
Rearrangements of the filamentous actin network involve a broad range of actin binding proteins. Among these, the gelsolin proteins sever actin filaments, cap their fast growing end and nucleate actin assembly in a calcium-dependent manner. Here, we focus on the gelsolin of the onychophoran Peripatoides novaezealandiae and the eutardigrade Hypsibius dujardini. From the cDNA of P. novaezealandiae we obtained the complete coding sequence with an open reading frame of 2178bp. It encodes a protein of 726 amino acids with a calculated molecular mass of 82,610...
September 11, 2016: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/27575439/plasma-gelsolin-as-a-potential-biomarker-for-henoch-schoenlein-purpura
#13
Y Kandur, A Çelik, F Gözübenli, A Çetinkaya, Ş Olgar
No abstract text is available yet for this article.
August 30, 2016: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/27573444/overexpression-of-gelsolin-reduces-the-proliferation-and-invasion-of-colon-carcinoma-cells
#14
Wen-Xiang Li, Meng-Xuan Yang, Xin-Qiang Hong, Tian-Geng Dong, Tuo Yi, Sheng-Li Lin, Xin-Yu Qin, Wei-Xin Niu
The enhanced motility of cancer cells via the remodeling of the actin cytoskeleton is crucial in the process of cancer cell invasion and metastasis. It was previously demonstrated that gelsolin (GSN) may be involved as a tumor or a metastasis suppressor, depending on the cell lines and model systems used. In the present study, the effect of GSN on the growth and invasion of human colon carcinoma (CC) cells was investigated using reverse transcription quantitative polymerase chain reaction and western blotting...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27554994/the-cellular-proteome-is-affected-by-a-gelsolin-bbgel1-during-morphological-transitions-in-aerobic-surface-versus-liquid-growth-in-the-entomopathogenic-fungus-beauveria-bassiana
#15
Pu-Hong He, Wei-Xia Dong, Xin-Ling Chu, Ming-Guang Feng, Sheng-Hua Ying
The gelsolin superfamily includes seven protein members: gelsolin, villin, adseverin, CapG, advillin, supervillin and flightless I. The gelsolin proteins are actin-binding proteins that contain three or six gelsolin-like domains, and they play important roles in remodelling actin dynamics and cellular processes in eukaryotes. The entomopathogenic fungus Beauveria bassiana expresses a unique CapG protein (BbGEL1) that contains three gelsolin-like domains. BbGEL1p is associated with actin during mycelial growth and plays an important role in fungal morphological transitions under both aerobic and submerged conditions...
November 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27543313/functional-implications-of-the-spectrum-of-bcl2-mutations-in-lymphoma
#16
REVIEW
Khushboo Singh, James M Briggs
Mutations in the translocated BCL2 gene are often detected in diffuse large B-cell lymphomas (DLBCLs), indicating both their significance and pervasiveness. Large series genome sequencing of more than 200 DLBCLs has identified frequent BCL2 mutations clustered in the exons coding for the BH4 domain and the folded loop domain (FLD) of the protein. However, BCL2 mutations are mostly contemplated to represent bystander events with negligible functional impact on the pathogenesis of DLBCL. BCL2 arbitrates apoptosis through a classic interaction between its hydrophobic groove forming BH1-3 domains and the BH3 domain of pro-apoptotic members of the BCL2 family...
July 2016: Mutation Research. Reviews in Mutation Research
https://www.readbyqxmd.com/read/27515207/in-the-diagnosis-of-neonatal-sepsis-importance-of-gelsolin-and-relationship-with-mortality-and-morbidity
#17
Hülya Halis, Tamer Gunes, Sabriye Korkut, Berkay Saraymen, Ahmet Şen, Osman Bastug, Adnan Öztürk, Selim Kurtoğlu
In spite of advances in neonatal care and the new generation of antibiotics, neonatal sepsis is still a major cause of morbidity and mortality. Early diagnosis of neonatal sepsis is difficult because clinical signs are non-specific. Thus, new biomarkers are still needed for diagnosis. Gelsolin is an actin-binding plasma protein. Furthermore, extracellular gelsolin binds lipopolysaccharide and lipoteichoic acid, which are major virulence factors of Gram-negative and Gram-positive bacteria. The result of this binding is the inhibition of gelsolin's F-actin depolymerizing activity...
September 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27513633/spinal-cord-stimulation-alters-protein-levels-in-the-cerebrospinal-fluid-of-neuropathic-pain-patients-a-proteomic-mass-spectrometric-analysis
#18
Anne-Li Lind, Payam Emami Khoonsari, Marcus Sjödin, Lenka Katila, Magnus Wetterhall, Torsten Gordh, Kim Kultima
OBJECTIVES: Electrical neuromodulation by spinal cord stimulation (SCS) is a well-established method for treatment of neuropathic pain. However, the mechanism behind the pain relieving effect in patients remains largely unknown. In this study, we target the human cerebrospinal fluid (CSF) proteome, a little investigated aspect of SCS mechanism of action. METHODS: Two different proteomic mass spectrometry protocols were used to analyze the CSF of 14 SCS responsive neuropathic pain patients...
August 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27480960/correction-atf3-suppresses-metastasis-of-bladder-cancer-by-regulating-gelsolin-mediated-remodeling-of-the-actin-cytoskeleton
#19
(no author information available yet)
No abstract text is available yet for this article.
August 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/27461278/podxl-linked-to-poor-prognosis-of-pancreatic-cancers-promotes-cell-invasion-via-binding-to-gelsolin
#20
Keisuke Taniuchi, Mutsuo Furihata, Seiji Naganuma, Ken Dabanaka, Kazuhiro Hanazaki, Toshiji Saibara
The cell-adhesion glycoprotein PODXL is associated with an aggressive tumor phenotype in several forms of cancer. Here, we report that high PODXL expression was an independent predictor of worse overall survival of pancreatic cancer patients, and that PODXL promoted pancreatic cancer cell motility and invasion by physically binding to the cytoskeletal protein gelsolin. Suppression of PODXL or gelsolin decreased membrane protrusions with abundant peripheral actin structures, and in turn inhibited cell motility and invasion...
July 27, 2016: Cancer Science
keyword
keyword
2288
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"