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https://www.readbyqxmd.com/read/29775898/particle-induced-sirt1-downregulation-promotes-osteoclastogenesis-and-osteolysis-through-er-stress-regulation
#1
Liang Zhang, Dongmei Bao, Peng Li, Zhidong Lu, Long Pang, Zhirong Chen, Haohui Guo, Zhihui Gao, Qunhua Jin
BACKGROUND: Sirtuin 1 (SIRT1) downregulation has been found to be induced by wear particles in aseptic prosthesis loosening (APL). Osteoclastogenesis and osteoclast activation are the main pathological factors associated with APL. However, whether SIRT1 downregulation contributes to the formation and activation of osteoclasts through the induction of endoplasmic reticulum (ER) stress is unclear. METHODS: To address this, an osteolysis mouse model was used in which animals were treated with the SIRT1 activator, resveratrol (RES), or an ER stress inhibitor, 4-PBA, for two weeks...
May 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29775758/lncrna-prncr1-regulates-osteogenic-differentiation-in-osteolysis-after-hip-replacement-by-targeting-mir-211-5p
#2
Zong-Ming Gong, Zhen-Yu Tang, Xiao-Liang Sun
BACKGROUND: Osteogenic differentiation and osteolysis after hip replacement are both associated with bone metabolism. Interaction between lncRNA PRNCR1 and miR-211-5p was analyzed to illuminate their roles in osteogenic differentiation and osteolysis. METHODS: The expression of PRNCR1, miR-211-5p and C-X-C chemokine receptor-4 (CXCR4) protein in tissues and mesenchymal stem cells (MSCs) were determined by qRT-PCR and Western blot, separately. The osteogenic differentiation was assessed by ALP activity detection and ARS staining...
May 15, 2018: Gene
https://www.readbyqxmd.com/read/29775130/taxonomy-of-clinical-encounters-during-the-first-90-days-post-delivery-of-an-initial-lower-limb-prosthesis
#3
Daniel Joseph Lee, Michael Wininger, David Mahler, Mark Parisi
BACKGROUND: The incidence and etiology of prosthetic services utilization is poorly understood during the first 90 days post-delivery of the initial lower limb prosthesis. This period is of critical importance, as prevailing policy dictates limits on the reimbursement for certain services provided during this time period. The first step in understanding the financial ramifications of such policy is to examine the taxonomy behind clinical encounters during this tenuous time period. OBJECTIVES: Quantify and categorize clinical encounters by incidence and etiology...
May 1, 2018: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/29774982/transcatheter-mitral-valve-implantation-in-rigid-mitral-annuloplasty-rings-potential-differences-between-complete-and-incomplete-rings
#4
Daisuke Hachinohe, Azeem Latib, Matteo Montorfano, Antonio Colombo
Transcatheter mitral valve implantation (TMVI) has been performed in high-risk and inoperable patients for degenerated mitral bioprostheses (TMVIinV) and failed annuloplasty rings (TMVIinR). TMVIinR is more challenging compared to TMVIinV because of the differences in dimensions, shapes, and contours between rings and valves. In this report, we present two clinical cases of TMVIinR that were treated by trans-septal implantation of a balloon-expandable prosthesis. In TMVI cases with an incomplete ring, the ring will be stretched out toward its anterior and commissural side, and the open side of the ring will increase in width...
May 18, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29773387/levan-based-fibrous-scaffolds-electrospun-via-co-axial-and-single-needle-techniques-for-tissue-engineering-applications
#5
Gülben Avsar, Deniz Agirbasli, Mehmet Ali Agirbasli, Oguzhan Gunduz, Ebru Toksoy Oner
This represents the first systematic study where levan polysaccharide was used to fabricate fibrous matrices by co-axial and single-needle electrospinning techniques. For this, hydrolyzed (hHL) and sulfated hydrolyzed (ShHL) Halomonas levan were chemically synthesized and used together with polycaprolactone (PCL) and polyethyleneoxide (PEO) for the spinning process. In co-axially spun matrices, ultimate tensile strength (UTS) were found to increase with increasing ShHL concentration and elongation at break of PCL + ShHL matrices increased up to ten-fold when compared to PCL matrices...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29773173/gene-expression-in-adverse-reaction-to-metal-debris-around-metal-on-metal-arthroplasty-an-rna-seq-based-study
#6
Antti Pemmari, Tiina Leppänen, Erja-Leena Paukkeri, Antti Eskelinen, Teemu Moilanen, Eeva Moilanen
Joint replacement surgery is a standard treatment of advanced osteoarthritis (OA). Since 2000, cobalt-chromium (CoCr) metal-on-metal (MoM) implants were widely used in hip arthroplasties. Some patients developed "adverse reaction to metal debris" (ARMD) around the prosthesis, resulting in a need for revision surgery. In the present study, we addressed the pathogenesis of ARMD by genome-wide expression analysis. Pseudosynovial ARMD tissue was obtained from revision surgery of Articular Surface Replacement (ASR, DePuy, Warsaw, IN, USA) hip arthroplasties...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29772584/survival-after-aortic-valve-replacement-with-bovine-or-porcine-valve-prostheses-a-systematic-review-and-meta-analysis
#7
Natalie Glaser, Veronica Jackson, Anders Franco-Cereceda, Ulrik Sartipy
BACKGROUND:  Bovine and porcine bioprostheses are commonly used for surgical aortic valve replacement. It is unknown if the long-term survival differs between the two valve types.We performed a systematic review and meta-analysis to compare survival in patients who underwent aortic valve replacement and received a bovine or a porcine prosthesis. METHODS:  We performed a systematic search of Medline, Embase, Web of Science, and the Cochrane Library. Cohort studies that compared survival between patients who underwent aortic valve replacement and received either a bovine or a porcine bioprosthesis and that reported overall long-term survival with hazard ratio (HR) and 95% confidence interval (CI) were included...
May 17, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29772308/prostheses-as-extensions-of-the-body-progress-and-challenges
#8
REVIEW
Maria Niedernhuber, Damiano G Barone, Bigna Lenggenhager
Recent years have seen a surge of interest in the incorporation of artificial limbs. This research promises to provide individuals with sensorimotor disorders such as amputations with prostheses which feel like their own body part. While neuroscience made a leap towards uncovering the basic neurocognitive mechanisms of bodily self-consciousness, the development of incorporated prosthetic limbs still faces substantial challenges in basic neuroscience and in clinical reality. Here we critically examine recent findings on prosthesis incorporation to aid patient rehabilitation in the context of advances in cognitive and applied neuroscience as well as technology...
May 14, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29771899/excess-cost-and-inpatient-stay-of-treating-deep-spinal-surgical-site-infections
#9
James Barnacle, Dianne Wilson, Christopher Little, Christopher Hoffman, Nigel Raymond
AIM: To determine the excess cost and hospitalisation associated with surgical site infections (SSI) following spinal operations in a New Zealand setting. METHODS: We identified inpatients treated for deep SSI following primary or revision spinal surgery at a regional tertiary spinal centre between 2009 and 2016. Excess cost and excess length of stay (LOS) were calculated via a clinical costing system using procedure-matched controls. RESULTS: Twenty-eight patients were identified...
May 18, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29770880/intraoperative-periprosthetic-femur-fracture-during-bipolar-hemiarthroplasty-for-displaced-femoral-neck-fractures
#10
Choon Chiet Hong, Nazrul Nashi, Jiong Hao Tan, Ruben Manohara, Wei Ting Lee, Diarmuid Paul Murphy
INTRODUCTION: We aim to review the incidence and risk factors for the development of intraoperative periprosthetic femur fractures while performing a bipolar hemiarthroplasty for displaced neck of femur fractures. Our secondary aim is to characterize the types of intraoperative periprosthetic fractures, the steps leading to the fractures, and the salvage treatments instituted. MATERIALS AND METHODS: 271 patients treated with bipolar hemiarthroplasty after traumatic displaced femoral neck fractures were retrospectively analyzed...
May 17, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29770589/short-term-follow-up-of-antibiotic-loaded-articulating-cement-spacers-in-two-stage-revision-of-infected-total-knee-arthroplasty-a-case-series
#11
Meng-Qiang Tian, Xian-Teng Yang, Xiao-Bin Tian, Yun-Bo Sun, Yuan-Hui Duan, Li Sun
OBJECTIVE: Infection of total knee arthroplasty (TKA) is a rare but devastating complication. Two-stage revision is an effective treatment for late infected TKA. This study aimed to assess the short-term results of two-stage revision using articulating antibiotic-loaded spacers. METHODS: Twenty-five patients (10 men and 15 women) were diagnosed with late infections after TKA and treated with two-stage revision from April 2006 to August 2010; 19 of these patients had TKA for osteoarthritis and 6 for rheumatoid arthritis...
May 17, 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29770556/reliability-of-the-animated-activity-questionnaire-for-assessing-activity-limitations-of-patients-with-hip-and-knee-osteoarthritis
#12
W F Peter, H C W de Vet, C B Terwee
OBJECTIVE: The aim of the study was to determine the internal consistency, test-retest reliability and measurement error of the Animated Activity Questionnaire (AAQ) for assessing activity limitations in hip and knee osteoarthritis (HKOA) patients. METHODS: A total of 1,177 patients, from six countries (the Netherlands, UK, France, Denmark, Italy and Spain), completed the AAQ, a questionnaire consisting of videos displaying 17 activities with 3-5 levels of performance, from which patients choose the video that best matches their own performance...
May 17, 2018: Musculoskeletal Care
https://www.readbyqxmd.com/read/29770290/current-surgical-strategies-and-techniques-of-aortic-valve-diseases-in-children
#13
REVIEW
Kun Wang, Huifeng Zhang, Bing Jia
While the long-term outcome of surgical aortic valvotomy (SAV) appears to be better than that of balloon aortic valvuloplasty (BAV) as the primary procedure of aortic valve stenosis, the surgical strategies and techniques of treating aortic valve disease in children in other situations remain controversial. Valve repair should be first considered while replacement is still unavoidable in some cases, and new repair techniques developed by innovative surgeons are gradually becoming adopted. Some complex repair procedures such as cusp extension, leaflet replacement/reconstruction have provided satisfactory outcomes...
April 2018: Translational Pediatrics
https://www.readbyqxmd.com/read/29768730/biofilm-in-voice-prosthesis-a-prospective-cohort-study-and-laboratory-tests-using-sonication-and-sem-analysis
#14
Jacopo Galli, Lea Calo', Duino Meucci, Monica Giuliani, Daniela Lucidi, Gaetano Paludetti, Riccardo Torelli, Maurizio Sanguinetti, Claudio Parrilla
OBJECTIVE: The objective of the study was to compare the biofilm growing pattern and its morphological extent on silicone and a teflon-like material using a sonication process and a Scanning Electron Microscope (SEM). DESIGN: A prospective cohort study and a laboratory study. SETTING: Otolaryngology -Head and Neck surgery Department and the Microbiology Institute. PARTICIPANTS: The participants included fifteen laryngectomized patients with phonatory prostheses, which were removed due to device failure, and two different kinds of phonatory prostheses from the laboratory (Provox 2 and ActiValve) that were artificially colonized by Candida albicans...
May 16, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29763505/influence-of-alveolar-bone-defects-on-the-stress-distribution-in-quad-zygomatic-implant-supported-maxillary-prosthesis
#15
Yuanyuan Duan, Ravi Chandran, Denise Cherry
PURPOSE: The purpose of this study was to create three-dimensional composite models of quad zygomatic implant-supported maxillary prostheses with a variety of alveolar bone defects around implant sites, and to investigate the stress distribution in the surrounding bone using the finite element analysis (FEA) method. MATERIALS AND METHODS: Three-dimensional models of titanium zygomatic implants, maxillary prostheses, and human skulls were created and assembled using Mimics based on microcomputed tomography and cone beam computed tomography images...
May 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29762930/cusp-tear-of-trifecta%C3%A2-aortic-bioprosthesis-resulting-in-acute-heart-failure
#16
Anne-Kristin Schaefer, Alfred Kocher, Günther Laufer, Dominik Wiedemann
Herein is presented the case of an 83-year-old male patient in cardiogenic shock with acute aortic regurgitation that occurred six years after aortic valve replacement (AVR) with a 23 mm Trifecta™ valve. Prosthesis endocarditis was initially suspected because of a floating structure attached to the aortic valve that was visible on echocardiography. Emergency redo-AVR surgery was performed, but no signs of endocarditis were found intraoperatively. Hence, cusp tearing of the implanted bioprosthesis was considered to be the reason for the severe aortic regurgitation...
September 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29762921/long-term-up-to-21-years-follow-up-after-biological-and-mechanical-aortic-valve-replacement-in-younger-patients
#17
Stanislav Tsvelodub, Barbara Pieper, Sina Stock, Hans-Hinrich Sievers, Doreen Richardt
BACKGROUND: Despite the limited durability of biological aortic valves, increasing numbers of younger patients are choosing to receive them, due mainly to the lack of a need for permanent anticoagulation. Few data exist, however, regarding the outcomes of valve replacement in patients aged <55 years, and additional data are required in this patient population. METHODS: Between 1993 and 2014, at the authors' institution, a total of 448 patients (237 males, 101 females; mean age 45...
September 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29762920/outcomes-of-a-new-generation-stentless-aortic-valve-a-single-center-experience-with-251-consecutive-implants
#18
Guglielmo Stefanelli, Fabrizio Pirro, Giuseppe Danniballe, Alina Olaru, Marco Meli, Luca Weltert
BACKGROUND: The study aim was to investigate the hemodynamic behavior over time and ease of implant and durability of the Sorin Pericarbon Freedom (SPF)® stentless pericardial aortic xenograft. METHODS: Between March 2003 and April 2010, a total of 251 consecutive, non-selected patients (mean age 70.1 years; range: 17-89 years; 17.1% aged >80 years) received a SPF bioprosthesis as an aortic valve substitute at the authors' institution. All implantations were performed by a single surgeon using a classical, double-line, subcoronary implant technique...
September 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29762447/gastrocnemius-myocutaneous-flaps-for-knee-joint-coverage
#19
Alice Mayoly, Jean-Camille Mattei, Pierre Moullot, Charlotte Jaloux, Alexandre Rochwerger, Dominique Casanova, Baptiste Bertrand, Cécile Philandrianos
INTRODUCTION: The gastrocnemius muscular flap has already proven its efficiency for soft tissue coverage in cases of knee joint exposure. However, it may be too small to cover large defects and has not the same aesthetic and mechanical properties as normal skin. Perforator fasciocutaneous flaps have recently been described in knee joint coverage with good results as they replace skin by skin, but they can be hard to harvest. Gastrocnemius flaps can be easily harvested with a planned skin paddle designed over the chosen muscle...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29762278/comparison-of-intermediate-to-long-term-outcomes-of-total-ankle-arthroplasty-in-ankles-with-preoperative-varus-valgus-and-neutral-alignment
#20
Gun-Woo Lee, Shao-Hua Wang, Keun-Bae Lee
BACKGROUND: Preoperative ankle coronal malalignment has been considered as a risk factor for poor outcomes and failure after total ankle arthroplasty. The present study evaluated whether intermediate to long-term outcomes of total ankle arthroplasty in ankles with preoperative varus and valgus malalignment (5° to 20°) are comparable with those with neutral alignment (<5°). METHODS: We enrolled 144 consecutive ankles that underwent primary total ankle arthroplasty (140 patients) using a mobile-bearing HINTEGRA prosthesis with a minimum follow-up of 4 years; the mean overall follow-up duration was 89 months (51 to 145 months)...
May 16, 2018: Journal of Bone and Joint Surgery. American Volume
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