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Dental injurents

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https://www.readbyqxmd.com/read/28806496/anterior-superior-alveolar-nerve-injury-after-extended-endoscopic-medial-maxillectomy-a-preclinical-study-to-predict-neurological-morbidity
#1
Alberto Schreiber, Davide Mattavelli, Marco Ferrari, Vittorio Rampinelli, Davide Lancini, Marco Ravanelli, Giacomo Bertazzoni, Luigi Fabrizio Rodella, Barbara Buffoli, Francesco Doglietto, Piero Nicolai
BACKGROUND: Endoscopic medial maxillectomies (EMMs) are used to optimize exposure of the maxillary sinus and retromaxillary areas. Although in type D EMM (Sturmann-Canfield procedure) the anterior superior alveolar nerve (ASAN) is always at risk of injury, only 29% of patients complained of alveolar process and dental anesthesia. The purpose of this anatomical study is to assess the neural anastomotic network of the ASAN (ASAN-NAN) and describe different extensions of type D EMMs in a preclinical setting...
August 14, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28776281/expression-of-optineurin-isolated-from-rat-injured-dental-pulp-and-the-effects-on-inflammatory-signals-in-normal-rat-kidney-cells
#2
Kyoko Senoo, Keisuke Yamashairo, Tadashi Yamamoto, Fumio Myokai, Mari Kawamura, Shogo Takashiba
We previously isolated rat 14.7K-interacting protein-2 (rFIP-2) from the rat-wounded pulp. The protein, homologous to human FIP-2, is known as optineurin and was initially identified as a novel tumor necrosis factor-α (TNF-α)-inducible protein, and more recently, as an autophagy receptor. However, the biological role of optineurin in dental pulp remains elusive. We hypothesized that optineurin has a crucial role in regulating molecular processes during pulp inflammatory responses induced by TNF-α. We examined the kinetics of optineurin expression in pulp inflammation...
August 3, 2017: Odontology
https://www.readbyqxmd.com/read/28762346/prevalence-of-traumatic-dental-injuries-among-visually-impaired-children-attending-special-schools-of-chhattisgarh
#3
Harsha Munot, Alok Avinash, Nilotpol Kashyap, Rashmi Baranwal, Brij Kumar, Maylavarapu Krishna Sagar
BACKGROUND: Studies on dental trauma of the normal population have been carried out in the past; however, limited data are available on dental trauma of the handicapped population, especially visually impaired children in Chhattisgarh, India. AIM: The aim of this study is to determine the prevalence of traumatic dental injuries (TDIs) in visually impaired children in relation to age, cause, and place of injury. MATERIALS AND METHODS: Epidemiological study was carried out among 400 children from various special schools of visually impaired children of Chhattisgarh followed by school dental checkup camps...
July 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28751918/cellular-responses-in-human-dental-pulp-stem-cells-treated-with-three-endodontic-materials
#4
Alejandro Victoria-Escandell, José Santiago Ibañez-Cabellos, Sergio Bañuls-Sánchez de Cutanda, Ester Berenguer-Pascual, Jesús Beltrán-García, Eva García-López, Federico V Pallardó, José Luis García-Giménez, Antonio Pallarés-Sabater, Ignacio Zarzosa-López, Manuel Monterde
Human dental pulp stem cells (HDPSCs) are of special relevance in future regenerative dental therapies. Characterizing cytotoxicity and genotoxicity produced by endodontic materials is required to evaluate the potential for regeneration of injured tissues in future strategies combining regenerative and root canal therapies. This study explores the cytotoxicity and genotoxicity mediated by oxidative stress of three endodontic materials that are widely used on HDPSCs: a mineral trioxide aggregate (MTA-Angelus white), an epoxy resin sealant (AH-Plus cement), and an MTA-based cement sealer (MTA-Fillapex)...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28724864/anatomic-and-histological-study-of-lingual-nerve-and-its-clinical-implications
#5
Yoshiaki Shimoo, Masahito Yamamoto, Masashi Suzuki, Masato Yamauchi, Akihiro Kaketa, Masaaki Kasahara, Masamitsu Serikawa, Kei Kitamura, Satoru Matsunaga, Shinichi Abe
Although the risk of injuring the lingual nerve in the mandibular molar area during dental treatment is high, it can be repaired by nerve grafting. However, from the perspective of clinical dentistry, the pathway and histomorphometric characteristics of this nerve remain to be documented in detail. The purpose of the present study was to morphologically elucidate the pathway of the lingual nerve to clarify its significance in a clinical setting. A histomorphometric analysis was also performed in consideration of nerve grafting...
2017: Bulletin of Tokyo Dental College
https://www.readbyqxmd.com/read/28667754/mta-induced-notch-activation-enhances-the-proliferation-of-human-dental-pulp-cells-by-inhibiting-autophagic-flux
#6
W Qiu, B Sun, F He, Y Zhang
AIM: To determine the roles of autophagy and Notch signalling in mineral trioxide aggregate (MTA)-mediated proliferation and differentiation of human dental pulp cells (hDPCs). METHODOLOGY: hDPCs were separated from human healthy molar teeth using collagenase I/dispase II digestion, and then cultured in α-MEM medium with 15% foetal bovine serum. hDPCs were seeded in 96-well plates, and cell counting kit assays were carried out to test their viability. Real-time quantitative polymerase chain reaction (qPCR) was used to evaluate ALP, Runx2, Notch1, Hes1, and Hey1 mRNA levels...
July 1, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28657463/transplantation-of-human-dental-pulp-derived-stem-cells-or-differentiated-neuronal-cells-from-human-dental-pulp-derived-stem-cells-identically-enhances-regeneration-of-the-injured-peripheral-nerve
#7
Imran Ullah, Ju-Mi Park, Young-Hoon Kang, June-Ho Byun, Dae-Geon Kim, Joo-Heon Kim, Dong-Ho Kang, Gyu-Jin Rho, Bong-Wook Park
Human dental mesenchymal stem cells isolated from the dental follicle, pulp, and root apical papilla of extracted wisdom teeth have been known to exhibit successful and potent neurogenic differentiation capacity. In particular, human dental pulp-derived stem cells (hDPSCs) stand out as the most prominent source for in vitro neuronal differentiation. In this study, to evaluate the in vivo peripheral nerve regeneration potential of hDPSCs and differentiated neuronal cells from DPSCs (DF-DPSCs), a total of 1 × 10(6) hDPSCs or DF-hDPSCs labeled with PKH26 tracking dye and supplemented with fibrin glue scaffold and collagen tubulization were transplanted into the sciatic nerve resection (5-mm gap) of rat models...
July 25, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28652553/establishment-of-experimental-models-to-evaluate-the-effectiveness-of-dental-trauma-splints
#8
Takahiro Shirako, Hiroshi Churei, Takahiro Wada, Motohiro Uo, Toshiaki Ueno
The purpose was to describe a novel simple experimental model of injured teeth for developing dental trauma splints (DTS), and to test various splints by combining use of this model and the Periotest(®) device. Rubber O-rings and spring washers were used to simulate and modify injured tooth mobility. Splinting effects were assessed among three kinds of DTS, including a composite splint and two wire-composite splints (1: rectangular orthodontic wire 0.533×0.635 mm, 2: cobalt-chromium alloy wire Φ0.9 mm). The Periotest values were measured three times for each tooth before and after splint insertion...
June 23, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28623553/-kaposi-s-disease-in-an-hiv-positive-child-with-probable-contamination-from-his-grandmother
#9
A Dicko, Y Fofana, A Traoré, S Berthé, S Touré, C Lamissa, B Guindo, A Keita, O Faye
Kaposi's disease in children with HIV is rarely reported in everyday practice. This is a case study of cutaneous Kaposi's disease revealing HIV in a 5-year-old child with polymorphic eruption of papules and nodules on the face, trunk, back, and limbs. Histopathological examination confirmed the diagnosis of Kaposi's disease. The child's HIV serology was positive with a CD4 count of 240/mm3, normochromic and normocytic anemia, and a hemoglobin level at 8.5 g/dl. It was found that the child, after early weaning from his HIV-negative mother, had repeatedly suckled his healthy grandmother, who had no skin lesions but was HIV1 positive...
June 16, 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28611689/monitoring-notch-signaling-associated-activation-of-stem-cell-niches-within-injured-dental-pulp
#10
Thimios A Mitsiadis, Javier Catón, Pierfrancesco Pagella, Giovanna Orsini, Lucia Jimenez-Rojo
Dental pulp stem/progenitor cells guarantee tooth homeostasis, repair and regeneration throughout life. The decision between renewal and differentiation of these cells is influenced by physical and molecular interactions with stromal cells and extracellular matrix molecules forming the specialized microenvironment of dental pulp stem cell niches. Here we study the activation of putative pulp niches after tooth injury through the upregulation of Notch signaling pathway. Notch1, Notch2, and Notch3 molecules were used as markers of dental pulp stem/progenitor cells...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28527850/complement-activation-by-pulp-capping-materials-plays-a-significant-role-in-both-inflammatory-and-pulp-stem-cells-recruitment
#11
Thomas Giraud, Pierre Rufas, Fanny Chmilewsky, Charlotte Rombouts, Jacques Dejou, Charlotte Jeanneau, Imad About
INTRODUCTION: The role of complement, especially through the C5a fragment, is well-known for the initiation of inflammation. Its involvement in regeneration has been shown more recently by the recruitment of mesenchymal stem cells. C5a can be produced locally by the pulp fibroblasts in response to injury or infection. This work aims to investigate the effect of different pulp capping biomaterials on complement activation and its possible influence on inflammatory and pulp stem cell recruitment...
May 17, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28527847/self-repaired-process-of-a-traumatized-maxillary-central-incisor-with-pulp-infarct-after-horizontal-root-fracture-monitored-by-laser-doppler-flowmetry-combined-with-tissue-oxygen-monitor
#12
Qian Liao, Wenjun Ye, Junli Yue, Xiaoxi Zhao, Ling Zhang, Lan Zhang, Dingming Huang, Qinghua Zheng
Achieving a precise diagnosis of the pulp status of traumatized teeth is difficult. The time to interfere through endodontic treatment for these teeth is greatly dependent on the doctor's experience. A 24-year-old male patient suffered a traumatic injury to tooth #9 that resulted in an apical root horizontal fracture 3 days before he came to the hospital. The injured tooth showed no response to pulp sensitivity testing at the first visit and was discolored 1 week later. Tooth #9 was immobilized to its adjacent teeth for 4 weeks by a composite splint...
May 17, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28492750/relationship-between-initial-attendance-after-dental-trauma-and-development-of-external-inflammatory-root-resorption
#13
Thiago Farias Rocha Lima, Emmanuel João Nogueira Leal da Silva, Brenda Paula Figueiredo de Almeida Gomes, José Flávio Affonso de Almeida, Alexandre Augusto Zaia, Adriana de Jesus Soares
This clinical study aimed to evaluate the relationship of the delay between dental trauma and the initial attendance to the development of external inflammatory root resorption in permanent teeth affected by severe luxation. Sixty-seven patients, aged between 11 and 56 years, presenting 133 injured teeth with closed apex (56 extrusive luxation, 69 lateral luxation and 8 intrusive luxation) were followed up for a minimum of 24 months. The time elapsed between dental trauma and the initial attendance was recorded...
January 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/28481371/musculoskeletal-disorders-and-perception-of-working-conditions-a-survey-of-brazilian-dentists-in-s%C3%A3-o-paulo
#14
Artênio José Ísper Garbin, Gabriella Barreto Soares, Renato Moreira Arcieri, Cléa Adas Saliba Garbin, Carlos Eduardo Siqueira
OBJECTIVES: To investigate the prevalence of work-related musculoskeletal disorders amongst dentists who work in public clinics in São Paulo, Brazil, to investigate their awareness of the presence of risk factors in the workplace, disability due to pain, and the influence of pain on this awareness and disability. MATERIAL AND METHODS: A cross-sectional study was conducted among 204 dentists who work in public health clinics in the northwest of São Paulo, Brazil...
May 8, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28465581/nerve-growth-factor-signalling-in-pathology-and-regeneration-of-human-teeth
#15
Thimios A Mitsiadis, Henry Magloire, Pierfrancesco Pagella
Nerve growth factor (NGF) is a key regulator of the development and differentiation of neuronal and non-neuronal cells. In the present study we examined the distribution of NGF and its low and high-affinity receptors, p75(NTR) and TrkA respectively, in permanent human teeth under normal and pathological conditions. In intact functional teeth, NGF, p75(NTR) and TrkA are weakly expressed in dental pulp fibroblasts and odontoblasts that are responsible for dentine formation, while the NGF and p75(NTR) molecules are strongly expressed in nerve fibres innervating the dental pulp...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28314941/neuropeptide-expression-and-morphometric-differences-in-crushed-alveolar-inferior-nerve-of-rats-effects-of-photobiomodulation
#16
Daniel Oliveira Martins, Fabio Martinez Dos Santos, Adriano Polican Ciena, Ii-Sei Watanabe, Luiz Roberto G de Britto, José Benedito Dias Lemos, Marucia Chacur
Inferior alveolar nerve (IAN) injuries may occur during various dental routine procedures, especially in the removal of impacted lower third molars, and nerve recovery in these cases is a great challenge in dentistry. Here, the IAN crush injury model was used to assess the efficacy of photobiomodulation (PBM) in the recovery of the IAN in rats following crushing injury (a partial lesion). Rats were divided into four experimental groups: without any procedure, IAN crush injury, and IAN crush injury with PBM and sham group with PBM...
May 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28282030/platelet-rich-plasma-for-regeneration-of-neural-feedback-pathways-around-dental-implants-a-concise-review-and-outlook-on-future-possibilities
#17
REVIEW
Yan Huang, Michael M Bornstein, Ivo Lambrichts, Hai-Yang Yu, Constantinus Politis, Reinhilde Jacobs
Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the peripheral neural feedback pathway and thus repairing the lack of periodontal mechanoreceptors after tooth extraction has been highlighted in the literature. Nevertheless, regenerating the nerve fibers and reconstructing the neural feedback pathways around osseointegrated implants remain a challenge...
March 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28252424/the-peculiarities-of-treatment-of-uncomplicated-and-complicated-dental-injuries-caused-by-trauma
#18
M Mamaladze, N Nizharadze, O Vadachkoria
Trauma related injuries of permanent teeth occur frequently and are the most pressing issue the dentists are facing today. In different age groups the same type of trauma affects the teeth with different frequencies. For instance, accident related dental trauma in children and adults affected permanent teeth in 30% and deciduous teeth in 20%, respectively. It should also be noted that front teeth are more susceptible to traumatic injuries compared to the incisors. Upper front teeth were injured in 72% of cases, while lower central, upper lateral incisors, canines and premolars only in 6-8%...
January 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28192031/neural-crest-stem-cells-can-differentiate-to-a-cardiomyogenic-lineage-with-an-ability-to-contract-in-response-to-pulsed-infrared-stimulation
#19
Jordan M Greenberg, Vicente Lumbreras, Daniel Pelaez, Suhrud M Rajguru, Herman S Cheung
INTRODUCTION: Cellular cardiomyoplasty has rapidly risen to prominence in the clinic following a myocardial infarction; however, low engraftment of transplanted cells limits the therapeutic benefit to these procedures. Recently, lineage-specific stem cells differentiated into cardiomyocytes have gained much attention to assist in the repair of an injured heart tissue; however, questions regarding the ideal cell source remain. In the present study, we have identified a source that is easy to extract stem cells from and show that the cells present have a high plasticity toward the cardiomyogenic lineage...
October 2016: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28123274/prosthodontics-an-arsenal-in-forensic-dentistry
#20
REVIEW
Lakshmana Rao Bathala, Narendra Kumar Rachuri, Srinivas Rao Rayapati, Sudheer Kondaka
After major disasters such as earthquakes, fires, floods, tsunami, bomb blasts or terrorist attacks, accurate, and early identification of the dead and injured becomes an utmost importance. Restorations, cariesteeth, missingteeth and/or prostheses are most useful aids for the dental identification. At times, only identifiable remains are a victim's partial or complete dentures. The central principle of dental identification is that postmortem dental remains can be compared with antemortem dental records which include, studycasts, radiographs, etc...
September 2016: Journal of Forensic Dental Sciences
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