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Celiac disease and igA

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https://www.readbyqxmd.com/read/29769033/case-report-on-pathogenetic-link-between-gluten-and-iga-nephropathy
#1
Stefano Costa, Giovanni Currò, Salvatore Pellegrino, Maria Cristina Lucanto, Giovanni Tuccari, Antonio Ieni, Giuseppina Visalli, Giuseppe Magazzù, Domenico Santoro
BACKGROUND: A relationship between IgA nephropathy (IgAN) and celiac disease (CD) has been reported. We show the pathogenetic link for the first time. CASE PRESENTATION: A 39-year-old man with cystic fibrosis (CF) and CF-related diabetes started to present gross hematuria, back pain and headache. At admission, laboratory analysis showed increase in serum creatinine of 1.5 mg/dl, together with hematuria and mild proteinuria (1 g/24 h). He underwent a renal biopsy to investigate the cause of hematuria and renal failure...
May 16, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29752728/a-retrospective-study-of-dermatitis-herpetiformis-from-an-immunobullous-disease-clinic-in-north-india
#2
Sanjeev Handa, Garima Dabas, Dipankar De, Rahul Mahajan, Debajyoti Chatterjee, Uma N Saika, Bishan D Radotra
BACKGROUND: Indian data on dermatitis herpetiformis (DH) is not available. The aim of this study was to investigate the demographic and clinicopathological characteristics of patients with DH and to study its association with other autoimmune diseases. METHODS: All data were collected from case record forms of patients registered in immunobullous disease clinic of our institute. The diagnosis was based on characteristic clinical and immuno/histopathological features...
May 11, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29750882/occurrence-of-serum-antibodies-against-wheat-alpha-amylase-inhibitor-0-19-in-celiac-disease
#3
D Sánchez, S Štěpánová-Honzová, M Hospodková, I Hoffmanová, V Hábová, P Halada, H Tlaskalová-Hogenová, L Tučková
The alcohol-soluble fraction of wheat gluten (gliadins) induces in genetically susceptible individuals immunologically mediated celiac disease (CLD). However, gliadins and related cereal proteins are not unique foodstuff targets of CLD patients´ immune system. Non-gluten wheat alpha-amylase inhibitor 0.19 (AAI 0.19) has been found to be capable of activating human monocyte-derived dendritic cells and inducing pro-inflammatory status in intestinal mucosa of patients with celiac disease (CLD). The possible contribution of this reactivity in incomplete remission of CLD patients on a gluten-free diet (GFD) is matter of contention...
May 10, 2018: Physiological Research
https://www.readbyqxmd.com/read/29749330/bone-mineral-density-and-vitamin-k-status-in-children-with-celiac-disease-is-there-a-relation
#4
Burcu Volkan, Ali Fettah, Ali İşlek, Soner Sertan Kara, Nezahat Kurt, Atilla Çayır
BACKGROUND/AIMS: To investigate bone mineral density (BMD) in children with celiac disease (CD) and to evaluate the association between vitamin K levels and osteoporosis. MATERIALS AND METHODS: Children with CD and age- and sex-matched healthy control subjects were prospectively included in the study. BMD was measured, and serum anti-tissue transglutaminase IgA, ferritin, folate, vitamin B12, 25-hydroxy vitamin D and K2, calcium, phosphate, alkaline phosphatase, and parathormone were assayed in all subjects...
March 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29709462/faecal-high-mobility-group-box-1-in-children-with-celiac-disease-a-pilot-study
#5
Francesca Palone, Roberta Vitali, Chiara Maria Trovato, Monica Montuori, Anna Negroni, Saverio Mallardo, Laura Stronati
BACKGROUND: Celiac disease (CD) is a gluten-related immunological disorder resulting in inflammatory enteropathy. AIMS: We assessed a stool marker of intestinal inflammation, the HMGB1 protein, in children with CD on a gluten free diet (GFD) at baseline and at follow up (FU). METHODS: Thirty-nine children were investigated at diagnosis and at FU. Traditional serum markers of CD (anti-transglutaminase and anti-endomysial antibodies) and faecal HMGB1 (by enzyme-linked immunosorbent assay and immunoblotting) were tested...
April 11, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29609063/comparison-of-diagnostic-performance-of-the-iga-anti-ttg-test-vs-iga-aga-test-in-detection-of-celiac-disease-in-the-general-population
#6
Anil K Verma, Simona Gatti, Elena Lionetti, Tiziana Galeazzi, Chiara Monachesi, Elisa Franceschini, Linda Balanzoni, Novella Scattolo, Mauro Cinquetti, Carlo Catassi
No abstract text is available yet for this article.
March 30, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29600122/addition-of-a-short-course-of-prednisolone-to-a-gluten-free-diet-vs-gluten-free-diet-alone-in-recovery-of-celiac-disease-a-pilot-randomized-controlled-trial
#7
Asad Abbas, Tabassum Shahab, Rana K Sherwani, Seema Alam
Background A gluten-free diet (GFD) is the standard of care in the management of patients with celiac disease, but clinical and histological recovery are often delayed. In newly diagnosed patients, strict compliance to GFD is difficult to achieve; this is especially true in developing countries where gluten-free food is often difficult to obtain. Steroids, when used alone, can be effective in inducing recovery in patients with celiac disease. We performed a randomized controlled trial to study the effect of a short course of prednisolone combined with a GFD on the recovery of celiac disease...
January 28, 2018: Curēus
https://www.readbyqxmd.com/read/29562371/the-frequency-of-celiac-disease-in-children-with-autoimmune-thyroiditis
#8
Y Sahin, O Evliyaoglu, T Erkan, F C Cokugras, O Ercan, T Kutlu
BACKGROUND AND AIMS: Although the presence of autoimmune thyroiditis (AT) in celiac disease (CD) has been well documented among adults, CD in AT has been less reported in children. We aimed to investigate the frequency of CD in children with AT. Materials and Methods : This prospective study was carried out from October 2015 to August 2016 and included 66 patients with AT. Firstly, total IgA and tissue transglutaminase antibody (tTG) IgA levels were measured. Those with increased level of tTG IgA were tested for anti-endomysium IgA antibodies (EMA)...
January 2018: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29561985/review-of-celiac-disease-presentation-in-a-pediatric-tertiary-centre
#9
Gracinda Nogueira Oliveira, Rajiv Mohan, Andrew Fagbemi
BACKGROUND: Celiac disease is an immune-mediated disorder with a multiform presentation and therefore a challenging diagnosis. OBJECTIVE: Our purpose is to identify the epidemiological, clinical, laboratory and histologic characteristics of children with celiac disease at diagnosis and on follow-up. METHODS: Children with previously established or newly diagnosed celiac disease, admitted in a tertiary centre in a two-year period (2014-2016) were recruited...
January 2018: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/29478494/safety-of-oats-in-children-with-celiac-disease-a-double-blind-randomized-placebo-controlled-trial
#10
Elena Lionetti, Simona Gatti, Tiziana Galeazzi, Nicole Caporelli, Ruggiero Francavilla, Salvatore Cucchiara, Paola Roggero, Basilio Malamisura, Giuseppe Iacono, Stefania Tomarchio, Wolfgang Kleon, Patrizia Restani, Ignazio Brusca, Andrea Budelli, Rosaria Gesuita, Flavia Carle, Carlo Catassi
OBJECTIVE: To evaluate the long-term validity and safety of pure oats in the treatment of children with celiac disease. STUDY DESIGN: This noninferiority clinical trial used a double-blind, placebo-controlled, crossover design extended over 15 months. Three hundred six children with a biopsy-proven diagnosis of celiac disease on a gluten-free diet for ≥2 years were randomly assigned to eat specifically prepared gluten-free food containing an age-dependent amount (15-40 g) of either placebo or purified nonreactive varieties of oats for 2 consecutive 6-month periods separated by washout standard gluten-free diet for 3 months...
March 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29473148/a-subset-of-patients-with-pemphigoid-herpes-gestationis-has-serological-evidence-of-celiac-disease
#11
Hedieh Saffari, John J Zone, Marjorie Allen, Kristin M Leiferman
BACKGROUND: Pemphigoid (herpes) gestationis (PG) is an uncommon, self-limited disease with other autoimmune associations; however, celiac disease (CD) is not recognized as one. METHODS: From 71 patients' sera submitted for herpes gestationis factor (HGF) testing over a 5-year period, 12 were consistent with PG demonstrating HGF and increased IgG BP180 antibody levels; these sera were tested for IgA and IgG endomysial antibodies (EMA), epithelial basement membrane zone and cell surface antibodies by indirect immunofluorescence, and for IgA and IgG tissue transglutaminase (transglutaminase 2 or TG2) antibodies, IgA epidermal transglutaminase (transglutaminase 3 or TG3) antibodies, IgG BP230, and IgG desmoglein 1 and desmoglein 3 antibodies by enzyme-linked immunosorbent assays (ELISAs)...
May 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29451364/prevalence-of-celiac-disease-in-adult-chinese-patients-with-diarrhea-predominant-irritable-bowel-syndrome-a-prospective-controlled-cohort-study
#12
Guan Jun Kou, Jing Guo, Xiu Li Zuo, Chang Qing Li, Chao Liu, Rui Ji, Han Liu, Xiao Wang, Yan Qing Li
OBJECTIVE: Celiac disease is a chronic inflammatory enteropathy with a symptom spectrum similar to that of irritable bowel syndrome (IBS). It is a common but largely undiagnosed condition in the Western countries. However, it is extremely rare among Chinese individuals, and few studies have investigated its prevalence in China. The aim was to determine the prevalence of celiac disease in patients with IBS who were diagnosed using the Rome III criteria in a single center of northern China...
March 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29396932/celiac-disease-in-children-with-moderate-to-severe-iron-deficiency-anemia
#13
Manish Narang, Ravikumar Natarajan, Dheeraj Shah, Amarender Singh Puri, Vikas Manchanda, Mrinalini Kotru
OBJECTIVE: To evaluate the proportion of children with moderate to severe iron-deficiency anemia who have associated celiac disease. METHODS: This cross-sectional analytical study was conducted among children aged 1 to 12 years of age with moderate-to-severe iron deficiency anemia and control children without anemia. Serum IgA-tissue trans-glutaminase levels were assessed in both cases and controls. All children with positive celiac serology underwent upper gastrointestinal endoscopy and duodenal biopsy; biopsy finding of Marsh grade 3 was considered positive for celiac disease...
January 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29383769/serum-intestinal-fatty-acid-binding-protein-in-the-noninvasive-diagnosis-of-celiac-disease
#14
Irene B Oldenburger, Victorien M Wolters, Tineke Kardol-Hoefnagel, Roderick H J Houwen, Henny G Otten
Current diagnostic guidelines for celiac disease (CD) in pediatric patients require a duodenal biopsy if the IgA anti-tissue transglutaminase (tTG) is below 10x the upper limit of normal (ULN). Additional markers may enable a noninvasive diagnosis in this group. Serum intestinal-fatty acid-binding protein (I-FABP), a marker for intestinal epithelial damage, could be useful in this respect. A total of 95 children with a clinical suspicion of CD and tTG 1-10x ULN were investigated. All had a duodenal biopsy and analysis of serum I-FABP...
March 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29379538/histologic-recovery-among-children-with-celiac-disease-on-a-gluten-free-diet-a-long-term-follow-up-single-center-experience
#15
Oana Belei, Andreea Dobrescu, Rodica Heredea, Emil Radu Iacob, Vlad David, Otilia Marginean
Introduction: Celiac disease (CD) is defined by gluten-induced immune-mediated enteropathy, affecting approximately 1% of the genetically predisposed population. The immunologic response to gluten causes characteristic intestinal alterations with gradual development. Histologic recovery of intestinal architecture was reported to occur within 6-12 months after starting a gluten-free diet, simultaneously with clinical remission. The aim of this study was to assess the rate and timing of histologic recovery among children with CD on a gluten-free diet, diagnosed and followed in an academic referral pediatric center during a 10-year period...
January 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29350070/celiac-antibodies-in-children-with-type-1-diabetes-a-diagnostic-validation-study
#16
Katarzyna Lewandowska, Olga Ciepiela, Agnieszka Szypowska, Jan Wyhowski, Eliza Głodkowska-Mrówka, Katarzyna Popko, Magdalena Ostafin, Beata Pyrżak, Urszula Demkow
INTRODUCTION: Autoimmune diseases, such as celiac disease (CD) and diabetes mellitus type 1, tend to co-occur within the same patient. The prevalence of CD in diabetic children is higher than in the general population, and is estimated to be 0.6-16.4%. The diagnosis of CD is based on histopathological examination and serological testing, however, these methods are still imperfect and new diagnostic algorithms should be considered. AIM: The aim of the study was to assess the diagnostic value of serological tests detecting antibodies against deamidated gliadin peptide, endomysium, tissue transglutaminase, neo-epitope tissue transglutaminase and to identify HLA-related genetic predisposition to CD in patients with type 1 diabetes mellitus (DM1)...
March 2018: Autoimmunity
https://www.readbyqxmd.com/read/29343966/prevalence-of-antigliadin-iga-antibodies-in-psoriasis-vulgaris-and-response-of-seropositive-patients-to-a-gluten-free-diet
#17
Nikolai A Kolchak, Maria K Tetarnikova, Maria S Theodoropoulou, Alexandra P Michalopoulou, Demetrios S Theodoropoulos
Introduction: The course of psoriasis relies on a variety of metabolic and immunological parameters. Identification of underlying pro-inflammatory conditions and their control is desired for optimal management. Background: Increased prevalence of serum markers for celiac disease has been reported among patients with psoriasis. The likelihood of occult celiac disease in a subpopulation of patients has been postulated and gluten-free diets have been reported to be effective...
2018: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/29302503/celiac-disease-in-south-jordan
#18
Eyad Altamimi
Purpose: Celiac disease, an autoimmune enteropathy triggered by exposure to gluten, is not uncommon in South Jordan. However, its prevalence is underestimated due to lack of physician awareness of the diversity of disease presentation. The clinical spectrum includes classic gastrointestinal manifestations, as well as rickets, iron-deficiency anemia, short stature, elevated liver enzymes, and edema. Our goal was to evaluate celiac disease presentation in clinically diagnosed children. Methods: Retrospective study included all children diagnosed with celiac disease between September 2009 and September 2015...
December 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/29260184/amaranth-addition-to-enzymatically-modified-wheat-flour-improves-dough-functionality-bread-immunoreactivity-and-quality
#19
N G Heredia-Sandoval, A M Calderón de la Barca, E Carvajal-Millán, A R Islas-Rubio
Consumers with gluten-related disorders require gluten-free (GF) foods to avoid an immune response. Alternative to the use of non-gluten containing grains to prepare GF bread, the gluten reactivity has been greatly reduced using a proline specific cleavage enzyme, however, the gluten functionality was lost. The aim of this study was to evaluate the effect of adding an amaranth flour blend (AFB) to enzymatically modified wheat-flour proteins on dough functionality and to evaluate the immunoreactivity and acceptability of the prepared bread...
January 24, 2018: Food & Function
https://www.readbyqxmd.com/read/29241120/a-study-on-the-association-of-mood-disorders-and-gluten-related-diseases
#20
Brunetta Porcelli, Valeria Verdino, Fabio Ferretti, Nicola Bizzaro, Lucia Terzuoli, Francesca Cinci, Letizia Bossini, Andrea Fagiolini
Our study aimed to evaluate the presence of antibodies related to gluten intolerance in patients with mood disorders. A total of 60 patients with a diagnosis of bipolar disorder or depressive disorder were recruited. Fourty-eight subjects randomly selected among unrelated family members were included as controls. Celiac disease-associated antibodies were assayed both in the patients and controls. Mean values of IgA/IgG anti-gliadin antibodies, IgA/IgG anti-deamidated gliadin peptide antibodies and IgA anti-transglutaminase (tTG) antibodies were not different between patients and controls...
December 6, 2017: Psychiatry Research
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