keyword
https://read.qxmd.com/read/38523882/do-serological-tests-eliminate-the-need-for-endoscopic-biopsy-for-the-diagnosis-of-symptomatic-patients-with-celiac-disease-a-retrospective-study-with-review-of-literature
#1
JOURNAL ARTICLE
Mohammad Hossein Anbardar, Neda Soleimani, Ehsan Torabi Dashtaki, Naser Honar, Mozhgan Zahmatkeshan, Sahand Mohammadzadeh
Background: Celiac disease is one of the most common genetic allergies worldwide. The prevalence of celiac disease in Iran is similar to or even higher than the global prevalence. Celiac disease is a chronic inflammatory disease that affects the small intestine. Affected patients are allergic to gluten protein that exists in some grains, such as wheat and barley. Methods: Serological endomysial IgA antibody (EMA-AB) and tissue transglutaminase IgA antibody (TTG-IgA) tests were performed on 114 patients aged the ages of 0-18 years with histopathological findings of celiac disease...
October 2023: Middle East Journal of Digestive Diseases
https://read.qxmd.com/read/38499339/new-entity-of-adult-ultra-short-coeliac-disease-the-first-international-cohort-and-case-control-study
#2
JOURNAL ARTICLE
Suneil A Raju, Emily A Greenaway, Annalisa Schiepatti, Giovanni Arpa, Nicoletta Vecchione, Chao LA Jian, Charlotte Grobler, Margherita Maregatti, Olivia Green, Freya J Bowker-Howell, Mohamed G Shiha, Hugo A Penny, Simon S Cross, Carolina Ciacci, Kamran Rostami, Shokoufeh Ahmadipour, Afshin Moradi, Mohammad Rostami-Nejad, Federico Biagi, Umberto Volta, Michelangelo Fiorentino, Benjamin Lebwohl, Peter Hr Green, Suzanne Lewis, Javier Molina-Infante, Pilar Mata-Romero, Valentina Vaira, Luca Elli, Irfan Soykan, Arzu Ensari, David S Sanders
BACKGROUND: Ultra-short coeliac disease (USCD) is defined as villous atrophy only present in the duodenal bulb (D1) with concurrent positive coeliac serology. We present the first, multicentre, international study of patients with USCD. METHODS: Patients with USCD were identified from 10 tertiary hospitals (6 from Europe, 2 from Asia, 1 from North America and 1 from Australasia) and compared with age-matched and sex-matched patients with conventional coeliac disease...
March 18, 2024: Gut
https://read.qxmd.com/read/38497882/association-between-parvovirus-b19-and-thyroid-celiac-autoantibodies-among-t1dm-pediatric-patients
#3
JOURNAL ARTICLE
H C Chandramoorthy, A A Shati, A A Aseeri, A Subramanian, A Alhanshani, E A H Almohseny, R Ram Mani, A Kumar, R A Ali Moosa, A Al-Hakami, K Chidambaram
OBJECTIVE: In recent years, an overwhelming association between Pediatric Type 1 Diabetes Mellitus (T1DM) and autoimmune diseases has been largely reported. The current study was designed to determine a possible association between autoimmune thyroiditis (AIT), celiac disease (CD) - associated autoantibodies, and Parvovirus B19 infection among pediatric T1DM cases in the southwestern region of Saudi Arabia. PATIENTS AND METHODS: Blood samples from age groups 1-18 years attending the Diabetic Clinic were collected over a period of 12 months...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38483287/non-invasive-markers-of-inflammation-and-protein-loss-augment-diagnosis-of-pediatric-celiac-disease
#4
JOURNAL ARTICLE
Kimberly A Sutton, Mai He, Changqing Ma, Ta-Chiang Liu, William A Faubion, Julie Hoffmann, Laura Linneman, Cynthia Rodriguez, Lori R Holtz
BACKGROUND: Circulating tissue transglutaminase IgA (TTG IgA) concentration is a sensitive and specific indicator of celiac disease, but discrepancies between serologic and histologic findings occur. We hypothesized that fecal markers of inflammation and protein loss would be greater in patients with untreated celiac disease than in healthy controls. Our study aims to evaluate multiple fecal and plasma markers in celiac disease and correlate these findings with serologic and histologic findings as non-invasive means of evaluating disease activity...
March 14, 2024: Clinical and Translational Gastroenterology
https://read.qxmd.com/read/38477348/longitudinal-screening-of-hla-risk-and-hla-nonrisk-children-for-celiac-disease-to-age-15-years-cipis-study
#5
JOURNAL ARTICLE
Michaela Boström, Charlotte Brundin, Sara Björck, Daniel Agardh
OBJECTIVES: Autoantibodies against tissue transglutaminase (tTG) are serological markers of celiac disease. The aim was to study the applicability of human leukocyte antigen (HLA)-genotyping and tTG autoantibodies in the screening of celiac disease in a longitudinal birth cohort followed to age 15 years. METHODS: Included were 13,860 HLA-DQ-genotyped children at birth and previously invited to a screening at age 3 and 9 years, respectively. HLA-DQB1*02 and/or DQB1*03:02 (HLA-risk) children were compared with non-HLA-DQB1*02 and non-DQB1*03:02 (HLA-nonrisk) children...
March 13, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38460606/celiac-disease-related-conditions-who-to-test
#6
JOURNAL ARTICLE
Fabiana Zingone, Julio C Bai, Christophe Cellier, Jonas F Ludvigsson
Celiac disease (CeD) is a chronic immune-mediated condition triggered by gluten consumption in genetically predisposed individuals. Approximately 1% of the general population is affected by the disorder. Disease presentation is heterogeneous, and despite growing awareness among physicians and the public, it continues to be underestimated. The most effective strategy for identifying undiagnosed CeD is proactive case-finding through serologic testing in high-risk groups. We reviewed the most recent evidence on the association between CeD and over 20 conditions...
March 7, 2024: Gastroenterology
https://read.qxmd.com/read/38453268/a-low-protein-plant-dominant-gluten-free-diet-for-immunoglobulin-a-nephropathy-and-focal-segmental-glomerulosclerosis
#7
REVIEW
Jason Patel, Kamyar Kalantar-Zadeh, Melanie Betz, Shivam Joshi
Immunoglobulin A nephropathy is the most common glomerulonephritis syndrome in the world, yet there is currently no cure. While blood pressure control, renin-angiotensin-aldosterone system inhibition, and immunosuppression may slow disease progression, low-protein diets, defined as a daily dietary protein intake of 0.6 to 0.8 g/kg body weight, may also decrease immune complex deposition and disease severity, as evidenced in animal models. The link between secondary immunoglobulin A nephropathy and celiac disease has also led to the rise of gluten-free diets and zinc supplementation as potential lifestyle modifications to help manage common immunoglobulin A nephropathy symptoms such as proteinuria and hematuria...
November 2023: Adv Kidney Dis Health
https://read.qxmd.com/read/38449276/prevalence-and-predictors-of-celiac-disease-in-children-with-constipation
#8
JOURNAL ARTICLE
Monika Meena, Manish Narang, Rajesh Kumar Meena, Anju Aggarwal
OBJECTIVES: To determine the prevalence of celiac disease and its predictors in children with constipation. METHODS: A hospital-based cross-sectional comparative study was conducted between November, 2018 to April, 2020. Children aged 1-12 years were screened for the presence of constipation as per ROME IV criteria and designated as cases. Age and sex matched healthy children with normal bowel habits were enrolled as comparison group. Participants underwent a detailed history and examination, and were screened for celiac disease by estimating serum anti-tissue transglutaminase IgA antibody levels (tTG-IgA)...
March 5, 2024: Indian Pediatrics
https://read.qxmd.com/read/38443736/a-dedicated-celiac-disease-program-improves-celiac-quality-care-metrics-and-short-term-outcomes-in-real-life
#9
JOURNAL ARTICLE
Andrew Ford, Kaitlin Payne, Claire Jansson-Knodell, Stacy Cavagnaro, Kendra Weekley, David Gardinier, Alberto Rubio-Tapia
BACKGROUND AND AIMS: Dedicated multidisciplinary programs in gastroenterology are emerging with the goal to improve care. There is little information about the effects of a celiac disease program on disease-related quality care metrics and outcomes. We aimed to compare quality care metrics, symptom resolution, and serological response among patients diagnosed and treated in a celiac disease program with a standard of care cohort. METHODS: We performed a retrospective cohort study with adult celiac disease patients...
March 5, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38432123/evaluation-of-hla-dq2-and-hla-dq8-haplotypes-in-patients-with-endometriosis-a-case-control-study
#10
JOURNAL ARTICLE
Marina P Andres, Alessandra Peloggia, Henrique M Abrao, Thais F Magalhaes, João Siufi Neto, Mauricio Simões Abrão
OBJECTIVE: To evaluate the relationship between genetic haplotypes associated with celiac disease (Human Leucocyte Antigen [HLA] DQ2 and DQ8) with the diagnosis, clinical presentation, and location of endometriosis in Brazilian women. METHOD: A retrospective cross-sectional study, was conducted in a Tertiary hospital. PATIENTS: Women aged 18-50 years who underwent HLA-DQ2 and HLA-DQ8 haplotype analysis. INTERVENTION: The patients were divided into endometriosis and control groups and evaluated for symptoms; endometriosis location, American Society for Reproductive Medicine (ASRM) stage, and the presence of anti-tissue transglutaminase IgA (anti-TgA), HLA-DQ2, and HLA-DQ8 markers...
2024: Clinics
https://read.qxmd.com/read/38427764/correlation-between-intestinal-stem-cell-niche-changes-and-small-bowel-crypt-failure-in-patients-with-treatment-na%C3%A3-ve-celiac-disease
#11
JOURNAL ARTICLE
Prasenjit Das, Sudha Battu, Lalita Mehra, Alka Singh, Muzaffar Ahmad, Ashish Agarwal, Ashish Chauhan, Anam Ahmad, Sreenivas Vishnubhatla, Siddhartha Datta Gupta, Vineet Ahuja, Govind Makharia
OBJECTIVES: We hypothesized that crypt failure in the small bowel results in villous flattening in patients with celiac disease (CeD). We investigated whether alterations in the stem cell niche (ISC) are responsible for this phenomenon. MATERIALS AND METHODS: We included 92 duodenal (D2/3) biopsies from treatment-naive patients of CeD and 37 controls. All underwent screening for serum anti-tissue transglutaminase and endoscopic upper small bowel biopsy. Immunohistochemical markers were used to investigate ISC niche alterations, including LGR5 for crypt basal cells (CBC), Bmi1 for position 4+ cells, β-Defensin for Paneth cells, R-spondin1 as WNT activator, transcription factor-4 as WNT transcription factor, BMP receptor1A as WNT inhibitor, fibronectin-1 as periepithelial stromal cell marker, H2AX as apoptosis marker, and Ki67 as proliferation marker...
February 19, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38391162/serological-screening-for-celiac-disease-by-endomysial-antibodies-in-patients-with-rheumatoid-arthritis
#12
JOURNAL ARTICLE
Mariam Ghozzi, Fatma Mechi, Alma Ben Salem, Ikram El Ahmer, Donia Rachel Mbarki, Sarra Melayah, Amani Mankai, Ibtissem Ghedira
Celiac disease (CD) and rheumathoid arthritis (RA) are both multi-factorial chronic inflammatory auto-immune diseases. In this retrospective study, we determined the frequency of CD in patients with RA using IgA anti-endomysial antibodies (EmA) and tried to explain this association. Indirect immunofluorescence on human umbilical cord was used to detect EmA in 215 patients with seropositive RA collected over a 4-year-period. Two thousand and five hundred healthy blood donors (HBD) served as control group...
February 24, 2024: Annales de Biologie Clinique
https://read.qxmd.com/read/38331244/predominantly-antibody-deficiency-and-the-association-with-celiac-disease-in-sweden-a-nationwide-case-control-study
#13
JOURNAL ARTICLE
Daniel V DiGiacomo, Bjorn Roelstraete, Benjamin Lebwohl, Peter H R Green, Lennart Hammarström, Jocelyn R Farmer, Hamed Khalili, Jonas F Ludvigsson
BACKGROUND: Predominantly antibody deficiency (PAD) is associated with non-infectious inflammatory gastrointestinal (GI) disease. Population estimates of celiac disease (CeD) risk in those with PAD are limited. OBJECTIVE: Estimate population risk of PAD in individuals with CeD. METHODS: We conducted a nationwide case-control study of Swedish individuals who received a diagnosis of CeD between 1997 and 2017 (n=34,980), matched to population comparators by age, sex, calendar year, and county...
January 23, 2024: Annals of Allergy, Asthma & Immunology
https://read.qxmd.com/read/38324966/reduced-expression-of-ankyrin-g-and-e-cadherin-in-duodenal-mucosal-biopsy-of-subjects-with-celiac-disease
#14
JOURNAL ARTICLE
Nidhi Sharma, Vikram Narang, Ajit Sood, Vandana Midha, Sabyasachi Senapati
Confirmatory diagnosis of celiac disease (CD) include histopathology of duodenal biopsy and tissue trans-glutaminase-IgA. Identification of tissue-specific histological markers is warranted to improve the diagnosis. A genetic study in CD identified the association of ankyrin-G that connects E-cadherin with β2-spectrin in epithelial cells of the duodenal tissue. We attempted to investigate the differential expression of ankyrin-G, E-cadherin and β2-spectrin in duodenal biopsy of CD subjects compared to non-CD controls...
January 22, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38317100/prevalence-of-celiac-related-antibodies-and-its-impact-on-metabolic-control-in-egyptian-children-with-type-1-diabetes-mellitus
#15
JOURNAL ARTICLE
Khaled A Abdel Baseer, Abdallah E Mohammed, Aya Mohamed Abo Elwafa, Hala M Sakhr
OBJECTIVE: The simultaneous presence of celiac disease and type 1 diabetes (T1DM) is coupled with more hazards of comorbidities and complications. This current study aimed to screen for celiac disease in Egyptian children with type 1 diabetes and evaluate its impact on glycemic control. METHODS: A cross-sectional study was verified with 200 Egyptian children diagnosed with T1DM and having a diabetic duration of less than five years. Testing for anti-tissue transglutaminase IgA (tTG-IgA), anti-tissue transglutaminase IgG (tTG-IgG), anti-Endomysial IgA (EMA), and Hb A1c levels were done...
February 5, 2024: BMC Pediatrics
https://read.qxmd.com/read/38291818/diagnostic-accuracy-of-a-novel-point-of-care-test-for-simultaneous-detection-of-anti-transglutaminase-iga-and-anti-deamidated-gliadin-igg-antibodies
#16
JOURNAL ARTICLE
Giuseppe Parrinello, Mirella Da Re, Francesca Grizzo, Simone Camelliti, Marzia Cozzi, Francesca Marinoni, Danilo Villalta
BACKGROUND: Point-of-care tests (POCTs) may have a role in detecting undiagnosed cases of Celiac disease (CD). We assessed the diagnostic accuracy of a novel POCT, compared with the conventional serological methods, for simultaneous anti-transglutaminase (tTG) IgA and anti-deamidated gliadin (DGP) IgG antibody detection. Furthermore, we evaluated the effect of different biological matrices (whole blood and serum) on test performance. METHODS: Serum and whole blood from celiac or suspected celiac patients who underwent duodenal biopsy were assayed for the presence of anti-tTG IgA and anti-DGP IgG both with the reference standard methods (Thermo Fisher Scientific, Uppsala, Sweden) and with the POCT (PRIMA Lab SA, Balerna, Switzerland)...
January 30, 2024: Journal of Clinical Laboratory Analysis
https://read.qxmd.com/read/38176661/accuracy-of-the-no-biopsy-approach-for-the-diagnosis-of-coeliac-disease-in-adults-a-systematic-review-and-meta-analysis
#17
JOURNAL ARTICLE
Mohamed G Shiha, Nicoletta Nandi, Suneil A Raju, Graeme Wild, Simon S Cross, Prashant Singh, Luca Elli, Govind K Makharia, David S Sanders, Hugo A Penny
BACKGROUND & AIMS: Current international guidelines recommend duodenal biopsies to confirm the diagnosis of coeliac disease in adult patients. However, growing evidence suggests that IgA anti-tissue transglutaminase (tTg) antibody levels ≥10 times the upper limit of normal (ULN) can accurately predict coeliac disease, eliminating the need for biopsy. We performed a systematic review and meta-analysis to evaluate the accuracy of the no-biopsy approach to confirm the diagnosis of coeliac disease in adults...
January 2, 2024: Gastroenterology
https://read.qxmd.com/read/38147608/celiac-disease-promising-biomarkers-for-follow-up
#18
REVIEW
Matěj Hrunka, Lubomír Janda, Michaela Šťastná, Tereza Pinkasová, Jakub Pecl, Lumír Kunovský, Petr Dítě, Petr Jabandžiev
Celiac disease is a common gastroenterological illness. Current diagnostics of the disease are based on serological markers and histology of duodenal biopsies. Hitherto, a strict gluten-free diet is the only effective treatment and is necessary for good control of the disease. Serological tests in current use have very high specificity and sensitivity for diagnostics, but in follow-up they have some limitations. Their levels do not accurately reflect mucosal healing, and they are unable to detect minimal transgressions in the diet...
December 22, 2023: Journal of Gastrointestinal and Liver Diseases: JGLD
https://read.qxmd.com/read/38140342/dynamics-of-serologic-change-to-gluten-in-celiac-disease-patients
#19
JOURNAL ARTICLE
Jack Syage, Ana Ramos, Vasiliy Loskutov, Anna Norum, Adam Bledsoe, Rok Seon Choung, Matthew Dickason, Jennifer Sealey-Voyksner, Joseph Murray
Serologic measures of tissue transglutaminase (tTG) immunoglobulin A (IgA) and deamidated gliadin peptide (DGP) IgA and immunoglobulin G (IgG) are hallmark tests utilized when diagnosing individuals for celiac disease (CeD) and for monitoring adherence to a gluten-free diet (GFD), currently the only available treatment for CeD. We address two issues in this study: (i) the relapse to seropositivity for CeD patients who resume a gluten containing diet and (ii) the correlation between two different tTG-IgA assays near the upper limit of normal (ULN) designated thresholds...
December 12, 2023: Nutrients
https://read.qxmd.com/read/38125690/celiac-disease-in-moroccan-children-diagnostic-characteristics-and-determinants-of-diagnosis-delay
#20
JOURNAL ARTICLE
Assia Mouslih, Karima El Rhazi, Nassiba Bahra, Mounia Lakhdar Idrissi, Moustapha Hida
Advances in the field of celiac disease have led to a better understanding of the disease, but it remains underdiagnosed and poses a daily challenge to clinicians to make a timely diagnosis. This study aims to analyze and describe diagnosis characteristics, diagnosis delay, and the factors influencing this delay in Moroccan children. Our study included 324 children diagnosed during the study period from January 01, 2010, to December 30, 2019, at the Department of Pediatrics, Hassan II University Hospital in Fez, Morocco...
December 2023: Curēus
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