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Celiac disease and igA

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https://www.readbyqxmd.com/read/28437323/lack-of-utility-of-anti-ttg-igg-to-diagnose-celiac-disease-when-anti-ttg-iga-is-negative
#1
Imad Absah, Abdul R Rishi, Rami Gebrail, Melissa R Snyder, Joseph A Murray
OBJECTIVES: Guidelines for diagnosing celiac disease (CD) recommend initial testing with a highly sensitive serologic test for anti-tissue transglutaminase immunoglobulin A antibodies (tTG IgA). When the probability of CD is high, IgA deficiency should be considered. The 2 approaches to address this include measuring "both tTG IgA and tTG IgG" or measuring "total IgA." We aim to assess the utility of an isolated positive tTG IgG result in diagnosing CD. METHODS: We conducted a retrospective review of patients undergoing serologic testing for CD from January 1997 to June 2014...
May 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28433781/prevalence-of-celiac-disease-autoimmunity-among-adolescents-and-young-adults-in-china
#2
Juanli Yuan, Chunyan Zhou, Jinyan Gao, Jingjing Li, Fenglian Yu, Jun Lu, Xin Li, Xiaozhong Wang, Ping Tong, Zhihua Wu, Anshu Yang, Yonghong Yao, Sarah Nadif, Heng Shu, Jiang Xu, Yujie Wu, Luud Gilissen, Hongbing Chen
BACKGROUND & AIMS: In China, epidemiological information on celiac disease autoimmunity is scarce and fragmented. We investigated the prevalence of celiac disease autoimmunity in the general Chinese population. METHODS: In a cross-sectional prospective study, 19,778 undiagnosed Chinese adolescents and young adults (16-25 years old) were recruited from consecutive new students who underwent routine physical examinations at 2 universities in Jiangxi, China from Sep...
April 19, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28413079/mexican-consensus-on-dyspepsia
#3
R Carmona-Sánchez, O Gómez-Escudero, M Zavala-Solares, M V Bielsa-Fernández, E Coss-Adame, A I Hernández-Guerrero, F Huerta-Iga, M E Icaza-Chávez, M A Lira-Pedrín, J A Lizárraga-López, A López-Colombo, A Noble-Lugo, J Pérez-Manauta, R H Raña-Garibay, J M Remes-Troche, J L Tamayo, L F Uscanga, F Zamarripa-Dorsey, M A Valdovinos Díaz, J A Velarde-Ruiz Velasco
Since the publication of the 2007 dyspepsia guidelines of the Asociación Mexicana de Gastroenterología, there have been significant advances in the knowledge of this disease. A systematic search of the literature in PubMed (01/2007 to 06/2016) was carried out to review and update the 2007 guidelines and to provide new evidence-based recommendations. All high-quality articles in Spanish and English were included. Statements were formulated and voted upon using the Delphi method. The level of evidence and strength of recommendation of each statement were established according to the GRADE system...
April 13, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28397343/celiac-disease-prevalence-in-a-large-series-of-patients-with-behcet-s-disease
#4
Erdem Koçak, Erdem Akbal, Yavuz Beyazit, Bilal Ergül, Arzu Karataş, Seyfettin Köklü, H Meral Ekşioğlu
AIM: There are common findings between Behçet's disease (BD) and celiac disease (CD) based on similar immunological pathogenesis and there is only limited data available investigating the link between these two diseases. Furthermore, documented gastrointestinal (GI) involvement with marked upper GI symptoms in BD has been rarely reported. The aim of this study was to assess the prevalence of CD and to evaluate endoscopic findings in Turkish BD patients. METHODS: A total of 210 BD patients were included in the study...
April 11, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28392744/big-differences-in-primary-care-celiac-disease-serological-markers-request-in-spain
#5
Maria Salinas, Maite López-Garrigós, Emilio Flores, Carlos Leiva-Salinas
INTRODUCTION: Celiac disease (CD) prevalence is increasing but the disorder remains undiagnosed. The study compares CD serology markers requested by General Practitioners (GPs) over time and geographical areas. The aim of the current research is to assess the inter-practice and temporal variability in the request of CD serology markers by GPs in Spain, and the differences between regions. MATERIALS AND METHODS: A cross-sectional study was conducted enrolling Spanish clinical laboratories...
February 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/28389733/celiac-disease-in-non-clinical-populations-of-japan
#6
Mai Fukunaga, Norihisa Ishimura, Chika Fukuyama, Daisuke Izumi, Nahoko Ishikawa, Asuka Araki, Akihiko Oka, Tomoko Mishiro, Shunji Ishihara, Riruke Maruyama, Kyoichi Adachi, Yoshikazu Kinoshita
BACKGROUND: Celiac disease is a chronic autoimmune enteropathy caused by gluten ingestion. While its prevalence in Western countries is reported to be as high as 1%, the prevalence has not been evaluated in a large-scale study of a Japanese population. The aim of our study was to clarify the possible presence of celiac disease in a Japanese non-clinical population as well as in patients showing symptoms suggestive of the disease. METHODS: Serum samples were collected from 2008 non-clinical adults and 47 patients with chronic unexplained abdominal symptoms between April 2014 and June 2016...
April 7, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28387776/enhanced-detection-of-quantum-dots-by-the-magnetohydrodynamic-effect-for-electrochemical-biosensing
#7
Daniel Martín-Yerga, Pablo Fanjul-Bolado, David Hernández-Santos, Agustín Costa-García
In this work, we describe the use of a magnetoelectrochemical support for screen-printed electrodes to improve the anodic stripping voltammetry of cadmium due to the generated magnetohydrodynamic (MHD) effect. To create a significant MHD effect, Fe(iii) was added at mM concentrations to the solution. The reduction of Fe(iii) simultaneously with the cadmium deposition on the electrode surface allowed the production of a high cathodic current, which generated a large Lorentz force capable of exerting a convective effect on the solution in the presence of the magnetic field...
April 7, 2017: Analyst
https://www.readbyqxmd.com/read/28387082/-severe-hepatitis-with-hypogammaglobulinaemia-iga-of-non-alcoholic-origin
#8
R Abu Serieh, E Wain, V Drion, M Van Severen
This clinical case describes a severe liver insufficiency associated with an IgA hypergammaglobulinaemia. The search for an etiology excluded all classical causes of hepatopathy and led to the diagnosis of celiac disease. Liver impairment improved with a gluten-free diet. This observation emphasizes the need for a careful etiological diagnosis of any hepatopathy; this may result in the discovery of a potentially reversible cause amenable to a simple therapeutic strategy.
February 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28357481/disulfide-modified-antigen-for-detection-of-celiac-disease-associated-anti-tissue-transglutaminase-autoantibodies
#9
Luis Carlos Rosales-Rivera, Samuel Dulay, Pablo Lozano-Sánchez, Ioanis Katakis, Josep Lluís Acero-Sánchez, Ciara K O'Sullivan
A simple and rapid immunosensor for the determination of the celiac disease-related antibody, anti-tissue transglutaminase, was investigated. The antigenic protein tissue transglutaminase was chemically modified, introducing disulfide groups through different moieties of the molecule (amine, carboxylic, and hydroxyl groups), self-assembled on gold surfaces, and used for the detection of IgA and IgG autoantibodies. The modified proteins were evaluated using enzyme-linked immunosorbent assay and surface plasmon resonance, which showed that only introduction of the disulfide groups through amine moieties in the tissue transglutaminase preserved its antigenic properties...
March 29, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28350935/screening-for-celiac-disease-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#10
REVIEW
Roger Chou, Christina Bougatsos, Ian Blazina, Katherine Mackey, Sara Grusing, Shelley Selph
Importance: Silent or subclinical celiac disease may result in potentially avoidable adverse health consequences. Objective: To review the evidence on benefits and harms of screening for celiac disease in asymptomatic adults, adolescents, and children 3 years and older for the US Preventive Services Task Force. Data Sources: Ovid MEDLINE, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews, searched to June 14, 2016...
March 28, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28343658/text-message-intervention-teach-improves-quality-of-life-and-patient-activation-in-celiac-disease-a-randomized-clinical-trial
#11
Kelly Haas, Andrew Martin, K T Park
OBJECTIVE: To determine the impact of the Text Message Educational Automated Compliance Help (TEACH) text message intervention as a pragmatic approach for patient engagement among adolescents with celiac disease (CD) as measured by gluten-free diet (GFD) adherence, patient activation, and quality of life (QOL). STUDY DESIGN: Randomized controlled trial with patient recruitment at a pediatric, university-based hospital and through social media; 61 participants ages 12-24 years with CD diagnosed at least 1 year were enrolled...
March 23, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28337237/relationship-between-helicobacter-pylori-infection-and-celiac-disease-a-cross-sectional-study-and-a-brief-review-of-the-literature
#12
Sebahat Basyigit, Oktay Unsal, Metin Uzman, Ferdane Sapmaz, Ozlem Ceylan Dogan, Ayse Kefeli, Zeliha Asilturk, Abdullah Ozgur Yeniova, Yasar Nazligul
INTRODUCTION: Whether Helicobacter pylori triggers celiac disease (CD) or protects against CD is currently the subject of research. In the literature, there are epidemiologic studies that have reported conflicting results regarding the association between H. pylori and CD. AIM: To compare the prevalence of CD autoantibody positivity and the levels of CD autoantibodies between H. pylori-positive and H. pylori-negative subjects. MATERIAL AND METHODS: This study was prospectively designed and included 240 dyspeptic patients who underwent upper gastrointestinal endoscopy with gastric and duodenal biopsies...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/28331568/lithophagia-as-a-clue-for-celiac-disease-a-case-report-and-literature-review
#13
Mosayeb Shahryar, Iraj Shahramian, Seyed Mohsen Dehghani, NoorMohammad Noori, Maryam Ataollahi
Lithophagia is a type of pica that might be resulted from Iron Deficiency Anemia (IDA) which is the frequent presenting signs of Celiac Disease (CD). A 5-year-old child with a two year history of the lithophagia with a, refractory IDA, abdominal distention and constipation. The child did not grow well and had failure to thrive. With suspicion to CD, TTg IgA level was measured and due to an incearse of TTg IgA level the patients were undergone esophagogastrodeudonoscpy and jejunal biopsy. The biopsy showed severe villous atrophy and an increase in limphoplasma cells...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/28276604/one-step-immunochromatographic-visual-assay-for-anti-transglutaminase-detection-in-organ-culture-system-an-easy-and-prompt-method-to-simplify-the-in-vitro-diagnosis-of-celiac-disease
#14
Marco Di Tola, Mariacatia Marino, Rossella Casale, Raffaele Borghini, Antonio Tiberti, Giuseppe Donato, Umberto Occhiuzzi, Antonio Picarelli
BACKGROUND: Anti-tissue transglutaminase (anti-tTG) and endomysium antibodies (EMA) are detectable in duodenal culture media of celiac disease (CD) patients. To improve the management of this organ culture system, we evaluated the anti-tTG occurrence by immunochromatographic assay (ICA). METHODS: A total of 103 CD patients and 41 disease controls underwent duodenal biopsy for the organ culture. In culture supernatants, IgA anti-tTG were tested by both enzyme-linked immunosorbent assay (ELISA) and ICA, IgA EMA were searched by indirect immunofluorescence analysis (iIFA)...
March 9, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28176232/celiac-disease-in-children-with-severe-acute-malnutrition-sam-a-hospital-based-study
#15
Neetu Beniwal, Gaurav Ameta, Chandra Kumar Chahar
OBJECTIVES: To evaluate the prevalence and clinical features of Celiac disease among children with severe acute malnutrition (SAM). METHODS: This prospective observational study was conducted in PBM Children Hospital, Bikaner from July 2012 through December 2013. All consecutively admitted children with SAM were recruited. All subjects were screened for Celiac disease by serological test for IgA-anti tissue Transglutaminase (IgA tTG) antibodies. All seropositive children underwent upper gastrointestinal endoscopy for small bowel biopsy for the confirmation...
February 8, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28168522/no-association-between-gluten-sensitivity-and-amyotrophic-lateral-sclerosis
#16
Anne E Visser, Raha Pazoki, Sara L Pulit, Wouter van Rheenen, Joost Raaphorst, Anneke J van der Kooi, Isis Ricaño-Ponce, Cisca Wijmenga, Henny G Otten, Jan H Veldink, Leonard H van den Berg
To examine evidence for a role of gluten sensitivity (GS) or celiac disease (CD) in ALS etiology, we included participants from a population-based case-control study in The Netherlands between January 2006 and December 2015. We compared levels and seroprevalence of IgA antibodies to tissue transglutaminase 6 (TG6) in 359 ALS patients and 359 controls, and to transglutaminase 2 (TG2) and endomysium (EMA) in 199 ALS patients and 199 controls. Questionnaire data on 1829 ALS patients and 3920 controls were examined for CD or gluten-free diets (GFD)...
April 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28161854/diagnostic-yield-of-isolated-deamidated-gliadin-peptide-antibody-elevation-for-celiac-disease
#17
Nicholas A Hoerter, Sarah E Shannahan, Jorge Suarez, Suzanne K Lewis, Peter H R Green, Daniel A Leffler, Benjamin Lebwohl
BACKGROUND: Serologic testing for celiac disease includes tissue transglutaminase and endomysial antibodies. In addition to these tools, assays for deamidated gliadin peptide antibodies have been shown to have sensitivity and specificity that are comparable to tissue transglutaminase testing, and are increasingly being used for celiac disease testing. AIMS: The goal of this study is to evaluate the utility of deamidated gliadin peptide (DGP) testing in the setting of a negative tissue transglutaminase (TTG) IgA test...
May 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28151032/the-frequency-of-the-celiac-disease-among-children-with-familial-mediterranean-fever
#18
Yasin Sahin, Amra Adrovic, Kenan Barut, Tufan Kutlu, Fugen Cullu-Cokugras, Sezgin Sahin, Ozgur Kasapcopur, Tulay Erkan
OBJECTIVES: We aimed to assess the frequency of celiac disease (CD) in patients with Familial Mediterranean Fever (FMF). METHODS: This is a prospective study was carried out from October 2015 to March 2016. A total of 303 patients with FMF were included. We used 98 sex- and age-matched healthy subjects as a control group. Levels of total IgA and tissue transglutaminase (tTG) IgA antibody were measured in all groups. Those with increased level of tTG IgA were tested for anti-endomysium IgA antibodies (EMA)...
February 2, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28149977/help-desk-is-an-intestinal-biopsy-necessary-when-the-blood-work-suggests-celiac-disease
#19
Clarissa Jb Hoff
It depends on the antibody levels in the blood work. Symptomatic patients with serologic levels of immunoglobulin A anti-tissue transglutaminase (IgA anti-tTG) or immunoglobulin G anti-deamidated gliadin peptide antibody (IgG anti-DGP) greater than 10 times the upper limits of normal--especially if they also are positive for endomysial antibodies (EMA) and human leukocyte antigen DQ2 (HLA-DQ2 or HLA-DQ8)--may not need an intestinal biopsy to confirm the diagnosis of celiac disease.
December 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/28140462/physiopathology-and-management-of-gluten-induced-celiac-disease
#20
REVIEW
Jitendra Kumar, Manoj Kumar, Rajesh Pandey, Nar Singh Chauhan
Proline- and glutamine-rich gluten proteins are one of the major constituents of cereal dietary proteins, which are largely resistant to complete cleavage by the human gastrointestinal (GI) digestive enzymes. Partial digestion of gluten generates approximately 35 amino acids (aa) immunomodulatory peptides which activate T-cell-mediated immune system, followed by immunological inflammation of mucosa leading to the onset of celiac disease (CD). CD is an autoimmune disease associated with HLA-DQ2/DQ8 polymorphism and dysbiosis of gut microbiota...
January 31, 2017: Journal of Food Science
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