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Celiac disease and igA

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https://www.readbyqxmd.com/read/29132967/unexplained-infertility-and-undiagnosed-celiac-disease-study-of-a-multiethnic-canadian-population
#1
Beth Gunn, Kellie E Murphy, Ellen M Greenblatt
OBJECTIVE: The aims of this study were to examine the prevalence of Celiac disease (CD) in Canadian women with unexplained infertility versus women with an identifiable cause of infertility and to assess the sensitivity of the point-of-care Biocard Celiac Test Kit versus standard serum serologic testing. METHODS: In this prospective cohort study, women aged 18 to 44 who were evaluated for infertility between February 2010 and May 2012 at a tertiary academic care fertility clinic in Toronto, ON, were invited to participate...
November 10, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29132529/celiac-disease-and-gluten-sensitivity
#2
REVIEW
Katharine C DeGeorge, Jeanetta W Frye, Kim M Stein, Lisa K Rollins, Daniel F McCarter
Celiac disease is an immune-mediated enteropathy triggered by gluten that affects genetically predisposed individuals, typically causing intestinal symptoms and malabsorption. Diagnosis requires stepwise evaluation with anti-tissue transglutaminase IgA and histologic analysis of the small bowel. Strict adherence to a gluten-free diet is the primary treatment. Patients with symptoms thought to be related to gluten but without evidence of celiac disease are difficult to diagnose and treat. Consider first advising general nutritional improvements...
December 2017: Primary Care
https://www.readbyqxmd.com/read/29114494/giardiasis-mimicking-celiac-disease-in-a-patient-of-common-variable-immunodeficiency
#3
Kumar Saurabh, Vijaya Lakshmi Nag, Daisy Khera, Poonam Elhence
An adolescent boy presented to pediatrics outpatient department with complaints of recurrent diarrhea, nausea, vomiting, and pedal edema since 3-4 months, with no relief even after taking treatment. His investigation revealed decreased serum IgA, IgG, and IgM levels with hypoproteinemia. Duodenal biopsy showed features of celiac disease (CD), but tissue transglutaminase IgA was negative. In stool examination, plenty of Giardia lamblia cysts and eggs of Hymenolepis nana were present. He improved on treatment and remained asymptomatic for 4 months...
July 2017: Tropical Parasitology
https://www.readbyqxmd.com/read/29094324/a-caucasian-american-patient-with-celiac-disease-diagnosed-in-japan-and-successfully-treated-with-a-gluten-free-diet
#4
Haruka Wada, Mari Hayashida, Taro Sato, Shintaro Minowa, Osamu Ikezaki, Tatsuya Mitsui, Miki Miura, Yoshihiko Ohmori, Daisuke Saito, Akihito Sakuraba, Hideo Kamiichi, Kengo Tokunaga, Makoto Mochizuki, Junji Shibahara, Hideaki Mori, Tadakazu Hisamatsu
We report the case of a 33-year-old Caucasian American man diagnosed with celiac disease in Japan. He presented to a community hospital because of chronic watery diarrhea and weight loss for 6 months. The laboratory data showed low serum albumin and serum cholesterol. A colonoscopy was normal. He was referred to our hospital for further work-up. Serum tissue transglutaminase immunoglobulin A (IgA) and endomysial antibody were positive. The HLA type was DQ2. Esophagogastroduodenoscopy (EGD) revealed nodular and mosaic-patterned mucosa from the bulb to the second part of the duodenum...
November 1, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29083383/evaluation-of-multiple-diagnostic-indicators-in-comparison-to-the-intestinal-biopsy-as-the-golden-standard-in-diagnosing-celiac-disease-in-children
#5
Elisabet Hollén, Malin Farnebäck, Tony Forslund, Karl-Eric Magnusson, Tommy Sundqvist, Karin Fälth-Magnusson
Celiac disease (CD) is a chronic small intestinal enteropathy triggered by gluten in genetically predisposed individuals. The susceptibility is strongly associated with certain human leukocyte antigen (HLA)-genes, but efforts are being made in trying to find non-HLA genes that are predictive for the disease. The criteria for diagnosing CD were previously based primarily on histologic evaluation of small intestinal biopsies, but nowadays are often based only on blood tests and symptoms. In this context, we elucidated the accuracy of three diagnostic indicators for CD, alone or in combination...
November 25, 2016: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29082741/point-of-care-testing-for-paediatric-coeliac-disease-in-the-new-espghan-era
#6
Michelle Shui Yee Lau, David S Sanders
One of the challenges in coeliac disease is the significant under-diagnosis despite the increasing prevalence and international guidelines for serological screening in appropriate patient cohorts. Several point-of-care tests for coeliac disease have been developed over the past decade with the aim of improving case detection using rapid and convenient testing. Most point-of-care tests, such as Biocard, detect anti-tissue transglutaminase (tTG) IgA antibodies, whereas Simtomax uniquely detects anti-deamidated gliadin peptide (DGP) IgA/IgG antibodies...
November 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29075563/increased-prevalence-of-celiac-disease-in-idiopathic-inflammatory-myopathies
#7
Olof Danielsson, Björn Lindvall, Claes Hallert, Magnus Vrethem, Charlotte Dahle
OBJECTIVES: Idiopathic inflammatory myopathies (IIM) are often associated with other immune-mediated diseases or malignancy. Some studies have reported a high frequency of celiac disease in IIM. The aim of this study was to investigate the prevalence of celiac disease, systemic inflammatory diseases, and malignancy in a cohort of IIM patients, and estimate the incidence of IIM in the county of Östergötland, Sweden. MATERIAL AND METHODS: We reviewed medical records and analyzed sera from 106 patients, fulfilling pathological criteria of inflammatory myopathy, for the presence of IgA antibodies against endomysium and gliadin...
October 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29050994/celiac-disease-or-positive-tissue-transglutaminase-antibodies-in-patients-undergoing-renal-biopsies
#8
Rakel Nurmi, Martti Metso, Ilkka Pörsti, Onni Niemelä, Heini Huhtala, Jukka Mustonen, Katri Kaukinen, Satu Mäkelä
BACKGROUND: An association between celiac disease and renal diseases has been suggested, but the results are controversial. AIMS: To investigate the prevalence of celiac disease autoimmunity among individuals undergoing renal biopsies and to evaluate whether co-existent celiac autoimmunity influences the clinical outcome of the renal disease. METHODS: The prevalence of celiac autoimmunity (previous diagnosis of celiac disease or positive tissue transglutaminase antibodies) was determined in 827 consecutive patients undergoing kidney biopsies due to clinical indications...
October 5, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29016564/the-role-of-an-iga-igg-deamidated-gliadin-peptide-point-of-care-test-in-predicting-persistent-villous-atrophy-in-patients-with-celiac-disease-on-a-gluten-free-diet
#9
Michelle S Lau, Peter D Mooney, William L White, Michael A Rees, Simon H Wong, Matthew Kurien, Nick Trott, Daniel A Leffler, Marios Hadjivassiliou, David S Sanders
OBJECTIVES: Mucosal healing is important in celiac disease (CD) for the prevention of complications. However, obtaining duodenal biopsies is invasive, and there is currently no reliable surrogate marker for histological remission in clinical practice. We aimed to assess the role of a point-of-care test (POCT) based on IgA/IgG-deamidated gliadin peptide, in detecting persistent villous atrophy (VA) in CD. METHODS: We prospectively recruited patients with CD attending endoscopy for the assessment of histological remission...
October 10, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28991835/celiac-disease-diagnosis-without-biopsy-is-a-10x-uln-anti-transglutaminase-result-suitable-for-a-chemiluminescence-method
#10
Giulia Previtali, Lisa Licini, Lorenzo D'Antiga, Antonio Marseglia, Rudi Ravasio, Francesca Nembrini, Salvatore Greco, Aurelio Sonzogni, Giovanna Azzarà, Paolo Ravelli, Maria Grazia Alessio
OBJECTIVES: 2012 ESPGHAN guidelines allow to establish a celiac disease (CD) diagnosis without duodenal biopsy in symptomatic pediatric patients with anti-tissue transglutaminase (anti-tTG) titers > 10 times the upper limit of normal (ULN). For some years now, new chemiluminescence immunoassays have been made available: it is important to establish the clinical performance of anti-tTG and to determine the cut-off best suited to predict Marsh ≥ 2 in order to avoid gastrointestinal endoscopy not only in children, but also in the adult population...
October 6, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28985731/screening-for-celiac-disease-in-poorly-controlled-type-2-diabetes-mellitus-worth-it-or-not
#11
Muhammed Kizilgul, Ozgur Ozcelik, Selvihan Beysel, Hakan Akinci, Seyfullah Kan, Bekir Ucan, Mahmut Apaydin, Erman Cakal
BACKGROUND: Recent studies have demonstrated that immune factors might have a role in the pathophysiology of insulin resistance and type 2 diabetes mellitus (T2DM). Inappropriate glycemic control in patients with T2DM is an important risk factor for the occurrence of diabetes complications. The prevalence of celiac disease (CD) is high in type 1 diabetes mellitus however, there are scarce data about its prevalence in T2DM. Our aim was to investigate the prevalence of celiac disease among insulin-using type 2 diabetes patients with inappropriate glycemic control...
October 6, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28974086/renal-disease-in-patients-with-celiac-disease-a-review
#12
Boonphiphop Boonpheng, Wisit Cheungpasitporn, Karn Wijarnpreecha
Celiac disease, an inflammatory disease of small bowel caused by sensitivity to dietary gluten and related protein, affects approximately 0.5-1% of the population in the Western world. Extraintestinal symptoms and associated diseases are increasingly recognized including diabetes mellitus type 1, thyroid disease, dermatitis herpetiformis and ataxia. There have also been a number of reports of various types of renal involvement in patients with celiac disease including diabetes nephropathy, IgA nephropathy, membranous nephropathy, membranoproliferative glomerulonephritis, nephrotic syndrome related to malabsorption, oxalate nephropathy, and associations of celiac disease with chronic kidney disease and end-stage kidney disease...
October 3, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28953524/iron-status-in-pediatric-celiac-disease-a-retrospective-chart-review
#13
Jelena Popov, Mina Baldawi, Lawrence Mbuagbaw, Michelle Gould, Heather Mileski, Herbert Brill, Nikhil Pai
This study assessed the role of serum ferritin as a non-invasive biomarker in the diagnosis and monitoring of pediatric celiac disease. A retrospective chart review was performed on patients < 18 years old at time of diagnosis (n = 193) between 1998-2015. 653 paired values demonstrated a weak negative correlation between serum ferritin and TTG-IgA (r = -0.114; p = 0.004), necessitating further evaluation. A significant relationship was found between reduction of TTG-IgA and increase in serum ferritin after institution of a gluten-free diet (p < 0...
September 26, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28950706/efficacy-of-a-point-of-care-test-based-on-deamidated-gliadin-peptides-for-the-detection-of-celiac-disease-in-pediatric-patients
#14
Isabel Polanco, Thabata Koester Weber, Eva Martínez-Ojinaga, Manuel Molina, Jesús Sarria
OBJECTIVE: The objective of the study was to assess the effectiveness of a point-of-care test (POCT) based on deamidated gliadin peptides (DGP) compared to the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) criteria diagnosis in the early detection of celiac disease (CD) in pediatric patients. METHODS: One hundred children (≤ 18 years) with suspected CD were selected, including siblings of celiac children that underwent gastroscopy for other gastrointestinal conditions...
November 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28929834/the-association-between-serological-markers-of-celiac-disease-and-idiopathic-recurrent-pregnancy-loss
#15
Esma Sarikaya, Aytekin Tokmak, Rifat Taner Aksoy, Meryem Kuru Pekcan, Murat Alisik, Afra Alkan
INTRODUCTION: Antiphospholipid syndrome, uterine anomalies, and chromosomal aberrations are identifiable causes of recurrent pregnancy loss (RPL). Herein, our aim is to investigate the relationship between celiac disease (CD) specific antitransglutaminase antibodies (ATA) and unexplained RPL. MATERIALS AND METHODS: This was a cross sectional case-control study conducted on 86 women (45 RPL and 41 controls) in a tertiary level maternity hospital. Elisa kit was used to determine ATA IgA and IgG levels...
October 2017: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/28883692/fluctuation-of-zonulin-levels-in-blood-vs-stability-of-antibodies
#16
Aristo Vojdani, Elroy Vojdani, Datis Kharrazian
AIM: To evaluate the measurement of zonulin level and antibodies of zonulin and other tight junction proteins in the blood of controls and celiac disease patients. METHODS: This study was conducted to assess the variability or stability of zonulin levels vs IgA and IgG antibodies against zonulin in blood samples from 18 controls at 0, 6, 24 and 30 h after blood draw. We also measured zonulin level as well as zonulin, occludin, vinculin, aquaporin 4 and glial fibrillary acidic protein antibodies in the sera of 30 patients with celiac disease and 30 controls using enzyme-linked immunosorbent assay methodology...
August 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28877470/strong-clonal-relatedness-between-serum-and-gut-iga-despite-different-plasma-cell-origins
#17
Rasmus Iversen, Omri Snir, Maria Stensland, José E Kroll, Øyvind Steinsbø, Ilma R Korponay-Szabó, Knut E A Lundin, Gustavo A de Souza, Ludvig M Sollid
Mucosal antigens induce generation of lamina propria plasma cells (PCs) that secrete dimeric immunoglobulin A (IgA) destined for transport across the epithelium. In addition, blood contains monomeric IgA. To study the relationship between mucosal and systemic antibody responses, we took advantage of celiac disease patient samples for isolation of gut PCs as well as serum IgA and IgG reactive with a gluten-derived peptide or the autoantigen transglutaminase 2. Proteomic analysis of serum IgA revealed antigen-specific V-gene preferences, which matched those found in gut PCs...
September 5, 2017: Cell Reports
https://www.readbyqxmd.com/read/28819290/progress-towards-non-invasive-diagnosis-and-follow-up-of-celiac-disease-in-children-a-prospective-multicentre-study-to-the-usefulness-of-plasma-i-fabp
#18
M P M Adriaanse, A Mubarak, R G Riedl, F J W Ten Kate, J G M C Damoiseaux, W A Buurman, R H J Houwen, A C E Vreugdenhil
This prospective study investigates whether measurement of plasma intestinal-fatty acid binding protein (I-FABP), a sensitive marker for small intestinal epithelial damage, improves non-invasive diagnosing of celiac disease (CD), and whether I-FABP levels are useful to evaluate mucosal healing in patients on a gluten-free diet (GFD). Ninety children with elevated tTG-IgA titres and HLA-DQ2/DQ8 positivity were included (study group). Duodenal biopsies were taken, except in those fulfilling the ESPGHAN criteria...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28753180/mass-screening-for-celiac-disease-among-school-aged-children-toward-exploring-celiac-iceberg-in-saudi-arabia
#19
Abdulrahman Al-Hussaini, Riccardo Troncone, Musa Khormi, Muath AlTuraiki, Wahid Alkhamis, Mona Alrajhi, Thana Halal, Mosa Fagih, Sahar Alharbi, Muhammed Salman Bashir, Aziz Elchentoufi
OBJECTIVES: We conducted this mass screening study to determine the prevalence of celiac disease (CD) and characterize the celiac iceberg among Saudi pediatric population in Riyadh, the capital city of Saudi Arabia. METHODS: Over the study period (January 2014 to June 2016), we have conducted a cross-sectional, mass screening, IgA-tissue transglutaminase (TTG-IgA)-based study on 7930 Saudi students from primary and intermediate schools in Riyadh. Students with positive TTG-IgA (> 20 U/L) were called in the hospital to undergo a repeat of TTG-IgA; in those with borderline positive TTG-IgA (20-60 U/L) IgA-endomyseal antibody (EMA-IgA) test was performed...
July 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28749395/comparative-study-of-clinical-features-of-patients-with-celiac-disease-those-with-concurrent-celiac-disease-type-1-diabetes-mellitus
#20
Sanjay Kumar Bhadada, Ashu Rastogi, Aakash Agarwal, Rashi Kochhar, Rakesh Kochhar, Anil Bhansali
BACKGROUND & OBJECTIVES: Celiac disease (CD) and type 1 diabetes mellitus (T1DM) share a common genetic locus and clinical manifestations. The present study was planned to compare clinical, biochemical and hormonal profiles of patients with CD and CD with T1DM. METHODS: Records of CD patients with age ≤20 yr, available anthropometric measurements, haematological, biochemical and hormonal workup with tissue transglutaminase IgA antibody and duodenal biopsy (Marsh grade) were screened...
March 2017: Indian Journal of Medical Research
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