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https://www.readbyqxmd.com/read/28730555/intermittent-versus-continuous-renal-replacement-therapy-in-acute-methanol-poisoning-comparison-of-clinical-effectiveness-in-mass-poisoning-outbreaks
#1
Sergey Zakharov, Jan Rulisek, Olga Nurieva, Katerina Kotikova, Tomas Navratil, Martin Komarc, Daniela Pelclova, Knut Erik Hovda
BACKGROUND: Intermittent hemodialysis (IHD) is the modality of choice in the extracorporeal treatment (ECTR) of acute methanol poisoning. However, the comparative clinical effectiveness of intermittent versus continuous modalities (CRRT) is unknown. During an outbreak of mass methanol poisoning, we therefore studied the effect of IHD versus CRRT on mortality and the prevalence of visual/central nervous system (CNS) sequelae in survivors. METHODS: The study was designed as prospective observational cohort study...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28727492/chronic-psychological-stress-seems-associated-with-elements-of-the-metabolic-syndrome-in-patients-with-ischaemic-heart-disease
#2
Natasha Bergmann, Søren Ballegaard, Jesper Krogh, Per Bech, Åke Hjalmarson, Finn Gyntelberg, Jens Faber
BACKGROUND AND OBJECTIVES: Chronic psychological stress, the metabolic syndrome (MS) and ischaemic heart disease (IHD) seem closely connected. In this study, we evaluate the association between chronic stress and elements of MS in patients with stable IHD. DESIGN: Cross-sectional cohort study. METHODS: Three hundred and fifty patients with stable IHD were included. Chronic stress was evaluated by the two questionnaires, Major Depression Inventory (MDI) and the psychological wellbeing index WHO-5, as well as by Pressure Pain Sensitivity (PPS), a physiological measure of hyperalgesia at the sternum known to be associated to elements of the chronic stress syndrome...
July 20, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28725085/multidimensional-poverty-household-environment-and-short-term-morbidity-in-india
#3
Bidyadhar Dehury, Sanjay K Mohanty
Using the unit data from the second round of the Indian Human Development Survey (IHDS-II), 2011-2012, which covered 42,152 households, this paper examines the association between multidimensional poverty, household environmental deprivation and short-term morbidities (fever, cough and diarrhoea) in India. Poverty is measured in a multidimensional framework that includes the dimensions of education, health and income, while household environmental deprivation is defined as lack of access to improved sanitation, drinking water and cooking fuel...
2017: Genus
https://www.readbyqxmd.com/read/28721515/prolonged-intermittent-renal-replacement-therapy-in-children
#4
REVIEW
Rajiv Sinha, Sidharth Kumar Sethi, Timothy Bunchman, Valentine Lobo, Rupesh Raina
Wide ranges of age and weight in pediatric patients makes renal replacement therapy (RRT) in acute kidney injury (AKI) challenging, particularly in the pediatric intensive care unit (PICU), wherein children are often hemodynamically unstable. Standard hemodialysis (HD) is difficult in this group of children and continuous veno-venous hemofiltration/dialysis (CVVH/D) has been the accepted modality in the developed world. Unfortunately, due to cost constraints, CVVH/D is often not available and peritoneal dialysis (PD) remains the common mode of RRT in resource-poor facilities...
July 18, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28715752/switching-to-sanitation-understanding-latrine-adoption-in-a-representative-panel-of-rural-indian-households
#5
Diane Coffey, Dean Spears, Sangita Vyas
Open defecation, which is still practiced by about a billion people worldwide, is one of the most compelling examples of how place influences health in developing countries. Efforts by governments and development organizations to address the world's remaining open defecation would be greatly supported by a better understanding of why some people adopt latrines and others do not. We analyze the 2005 and 2012 rounds of the India Human Development Survey (IHDS), a nationally representative panel of households in India, the country which is home to 60% of the people worldwide who defecate in the open...
July 6, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28714023/protective-effects-of-shexiang-tongxin-dropping-pill-on-pituitrin%C3%A2-induced-acute-myocardial-ischemia-in-rats
#6
Shan Lin, Jianfeng Chu, Ling Zhang, Daxin Chen, Fei Xiao, Hongwei Chen, Jiumao Lin, Youqin Chen, Yuling Zhu, Jun Peng
Shexiang Tongxin Dropping Pill (STP) is an established traditional Chinese medicine that is widely used for the treatment of ischemic heart disease (IHD), although its mechanisms remain unclear. The present study investigated the protective effects of STP following pituitrin (PTT)‑induced myocardial ischemia in rats. ST‑segment elevation, blood rheology, and the serum levels of creatine kinase‑MB (CK‑MB) and lactate dehydrogenase (LDH) were measured. Following heart excision, histological analysis using hematoxylin and eosin and terminal deoxynucleotidyl transferase dUTP nick end labeling were performed...
July 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28705603/ischemic-heart-disease-in-children-and-young-adults-with-congenital-heart-disease-in-sweden
#7
Maria Fedchenko, Zacharias Mandalenakis, Annika Rosengren, Georg Lappas, Peter Eriksson, Kristofer Skoglund, Mikael Dellborg
BACKGROUND: An increasing proportion of congenital heart disease (CoHD) patients survive to an age associated with increased risk of developing ischemic heart disease (IHD). The aim was to investigate the risk of developing IHD among children and young adults with CoHD. METHODS: Using the Swedish National Patient Register, we created a cohort of all CoHD patients born between January 1970 and December 1993. Ten controls matched for age, sex, county were randomly selected from the general population for each patient (n=219,816)...
July 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28701344/syp1-regulates-the-clathrin-mediated-and-clathrin-independent-endocytosis-of-multiple-cargo-proteins-through-a-novel-sorting-motif
#8
Amanda Reider Apel, Kyle Hoban, Silvia Chuartzman, Raffi Tonikian, Sachdev Sidhu, Maya Schuldiner, Beverly Wendland, Derek Prosser
Internalization of proteins from the plasma membrane (PM) allows for cell-surface composition regulation, signaling network modulation, and nutrient uptake. Clathrin-mediated endocytosis (CME) is a major internalization route for PM proteins. During CME, endocytic adaptor proteins bind cargos at the cell surface and link them to the PM and clathrin coat. Muniscins are a conserved family of endocytic adaptors, including Syp1 in budding yeast and its mammalian ortholog, FCHo1. These adaptors bind cargo via a C-terminal ì-homology domain (ìHD); however, few cargos exhibiting muniscin-dependent endocytosis have been identified, and the sorting sequence recognized by the μHD is unknown...
July 12, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28692760/current-trends-in-admissions-and-outcomes-of-cardiac-diseases-in-ghana
#9
Lambert T Appiah, Fred S Sarfo, Charles Agyemang, Humphrey O Tweneboah, Nana Akua B A Appiah, George Bedu-Addo, Ohene Opare-Sem
Cardiovascular diseases (CVDs) pose a major burden in Africa, but data on temporal trends in disease burden are lacking. We assessed trends in CVD admissions and outcomes in central Ghana using a retrospective analysis of data from January 2004 to December 2015 among patients admitted to the medical wards of a tertiary medical center in Kumasi, Ghana. Rates of admissions and mortality were expressed as CVD admissions and deaths divided by the total number of medical admissions and deaths, respectively. Case fatality rates per specific cardiac disease diagnosis were also computed...
July 10, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28678807/risk-of-cardiovascular-disease-in-chinese-patients-with-rheumatoid-arthritis-a-cross-sectional-study-based-on-hospital-medical-records-in-10-years
#10
Kun Zou, Fu-Kun Xiao, Hong-Ying Li, Qiao Zhou, Lu Ban, Min Yang, Chang-Fu Kuo, Weiya Zhang
OBJECTIVE: Though the risk of cardiovascular disease (CVD) in rheumatoid arthritis (RA) has been established in Western population, little is known about the risk in Chinese people with RA. Our objective was to estimate the risk of CVD in Chinese people with RA using hospital medical records data. METHODS: The inpatients medical record database 2005-2015 of Sichuan provincial people's hospital was examined. All individuals with a primary diagnosis of RA were included as cases, and those of osteoarthritis (OA) were included as controls, which consisted of the unmatched dataset...
2017: PloS One
https://www.readbyqxmd.com/read/28676244/diagnostic-yield-of-cardiovascular-magnetic-resonance-in-young-middle-aged-patients-with-high-grade-atrio-ventricular-block
#11
A Baritussio, A Ghosh Dastidar, A Frontera, N Ahmed, E De Garate, I Harries, I Diab, E Duncan, G Thomas, A Nisbet, C Bucciarelli-Ducci
BACKGROUND: Atrio-ventricular block (AVB) is a rare finding in young or middle-aged adults, often leading to pacemaker implantation (PM) without further investigation. We sought to assess the diagnostic role of cardiovascular magnetic resonance (CMR) in young and middle-aged adults with high-grade AVB. METHODS: We consecutively enrolled young-middle aged (18-65years) patients with high grade AVB referred to CMR after standard clinical assessment (history, electrocardiogram and cardiac rhythm monitoring) prior to PM implantation...
June 21, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28673375/dietary-inflammatory-index-in-relation-to-sub-clinical-atherosclerosis-and-atherosclerotic-vascular-disease-mortality-in-older-women
#12
Nicola P Bondonno, Joshua R Lewis, Lauren C Blekkenhorst, Nitin Shivappa, Richard J Woodman, Catherine P Bondonno, Natalie C Ward, James R Hébert, Peter L Thompson, Richard L Prince, Jonathan M Hodgson
Arterial wall thickening, stimulated by low-grade systemic inflammation, underlies many cardiovascular events. As diet is a significant moderator of systemic inflammation, the dietary inflammatory index (DIITM) has recently been devised to assess the overall inflammatory potential of an individual's diet. The primary objective of this study was to assess the association of the DII with common carotid artery-intima-media thickness (CCA-IMT) and carotid plaques. To substantiate the clinical importance of these findings we assessed the relationship of DII score with atherosclerotic vascular disease (ASVD)-related mortality, ischaemic cerebrovascular disease (CVA)-related mortality and ischaemic heart disease (IHD)-related mortality more...
July 4, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28671630/prevalence-of-inherited-hemoglobin-disorders-and-relationships-with-anemia-and-micronutrient-status-among-children-in-yaound%C3%A3-and-douala-cameroon
#13
Reina Engle-Stone, Thomas N Williams, Martin Nankap, Alex Ndjebayi, Marie-Madeleine Gimou, Yannick Oyono, Ann Tarini, Kenneth H Brown, Ralph Green
Information on the etiology of anemia is necessary to design effective anemia control programs. Our objective was to measure the prevalence of inherited hemoglobin disorders (IHD) in a representative sample of children in urban Cameroon, and examine the relationships between IHD and anemia. In a cluster survey of children 12-59 months of age (n = 291) in Yaoundé and Douala, we assessed hemoglobin (Hb), malaria infection, and plasma indicators of inflammation and micronutrient status. Hb S was detected by HPLC, and α⁺thalassemia (3...
July 3, 2017: Nutrients
https://www.readbyqxmd.com/read/28664359/adverse-cardiac-events-associated-with-incident-opioid-drug-use-among-older-adults-with-copd
#14
Nicholas T Vozoris, Xuesong Wang, Peter C Austin, Douglas S Lee, Anne L Stephenson, Denis E O'Donnell, Sudeep S Gill, Paula A Rochon
PURPOSE: We evaluated whether incident opioid drug use was associated with adverse cardiac events among older adults with chronic obstructive pulmonary disease (COPD). METHODS: This was an exploratory, retrospective cohort study using health administrative data from Ontario, Canada, from 2008 to 2013. Using a validated algorithm, we identified adults aged 66 years and older with non-palliative COPD. Hazard ratios (HR) were estimated for adverse cardiac events within 30 days of incident opioid receipt compared to controls using inverse probability of treatment weighting using the propensity score...
June 29, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28663363/first-and-recurrent-ischaemic-heart-disease-events-continue-to-decline-in-new-zealand-2005-2015
#15
Corina Grey, Rod Jackson, Susan Wells, Billy Wu, Katrina Poppe, Harvey White, Wing Cheuk Chan, Andrew J Kerr
OBJECTIVES: To examine recent trends in first and recurrent ischaemic heart disease (IHD) deaths and hospitalisations. METHODS: Using anonymous patient-linkage of routinely collected data, all New Zealanders aged 35-84 years who experienced an International Statistical Classification of Diseases and Related Health Problems I(CD)-coded IHD hospitalisation and/or IHD death between 1 January 2005 and 31 December 2015 were identified. A 10-year look-back period was used to differentiate those experiencing first from recurrent events...
June 29, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28651854/estimating-the-effect-of-differing-assumptions-on-the-population-health-impact-of-introducing-a-reduced-risk-tobacco-product-in-the-usa
#16
Peter N Lee, John S Fry, John F Hamling, Zheng Sponsiello-Wang, Gizelle Baker, Rolf Weitkunat
We use Population Health Impact Modelling to assess effects on tobacco prevalence and mortality of introducing a Reduced Risk Tobacco Product (RRP). Simulated samples start in 1990 with a US-representative smoking prevalence. Individual tobacco histories are updated annually until 2010 using estimated probabilities of switching between never/current/former smoking where the RRP is not introduced, with current users subdivided into cigarette/RRP/dual users where it is. RRP-related mortality reductions from lung cancer, IHD, stroke and COPD are derived from the histories and the assumed relative risks of the RRP...
June 24, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28646026/exosomes-promising-sacks-for-treating-ischemic-heart-disease
#17
Gui-Hao Chen, Jun Xu, Yue-Jin Yang
Ischemic heart disease(IHD) is the leading cause of death worldwide. Despite development of continuously improving therapeutic strategies, morbidity and mortality of patients with IHD remains relatively high. Exosomes are a subpopulation of vesicles that are universally recognized as major mediators in intercellular communication. Numerous preclinical studies showed that these tiny vesicles were protective in IHD, through such actions as alleviating myocardial ischemia/reperfusion injury, promoting angiogenesis, inhibiting fibrosis and facilitating cardiac regeneration...
June 23, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28639375/challenges-in-regenerating-the-diabetic-heart-a-comprehensive-review
#18
REVIEW
Venkata R Satthenapalli, Regis R Lamberts, Rajesh Katare
Stem cell therapy is one of the promising regenerative strategies developed to improve cardiac function in patients with ischemic heart diseases (IHD). However, this approach is limited in IHD patients with diabetes due to a progressive decline in the regenerative capacity of stem cells. This decline is mainly attributed to the metabolic memory incurred by diabetes on stem cell niche and their systemic cues. Understanding the molecular pathways involved in the diabetes-induced deterioration of stem cell function will be critical for developing new cardiac regeneration therapies...
June 22, 2017: Stem Cells
https://www.readbyqxmd.com/read/28633950/a-multi-scale-integrated-modeling-framework-to-measure-comprehensive-impact-of-coastal-reclamation-activities-in-yellow-river-estuary-china
#19
Yan Xu, Yanpeng Cai, Tao Sun, Qian Tan
In this paper, an improved multi-scale integrated modeling framework has been established to evaluate coastal reclamation intensity (CRI). About 7 indicators are considered, including ecological degradation intensity (EDI), hydrodynamic disturbance (IHD), engineering types, water quality, economic investment, population growth, and reclaimed land area. Meanwhile, an integrated framework enhanced methods in terms of (a) measuring intensity of ecological degradation process under multi-scale impact, (b) developing the indicator system of CRI, and discussing the driving forces and trends of coastal reclamation, (c) determining fuzzy preference relations of weight and calculating the specific value of CRI with the case study areas of Yellow River estuary from 2000 to 2015...
June 17, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28633199/diffuse-type-caroli-disease-with-characteristic-central-dot-sign-complicated-by-multiple-intrahepatic-and-common-bile-duct-stones
#20
Moon Joo Hwang, Tae Nyeun Kim
Caroli disease (CD) is a rare congenital malformation of the liver characterized by non-obstructive, segmental, cystic dilatation of the intrahepatic bile ducts (IHDs). The clinical course is usually asymptomatic for the first 5-20 years, and symptoms may seldom occur throughout the patient's life. Bile stagnation leads to recurrent episodes of cholangitis, stone formation, or liver abscesses, and biliary cirrhosis usually occurs years later. Here we report on a 42-year-old man diagnosed with diffuse-type CD with a characteristic central dot sign, who had multiple intrahepatic and common bile duct (CBD) stones...
June 20, 2017: Clinical Endoscopy
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