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Rebecca Maxson, Julia Pate, Jessica Starr
BACKGROUND: Current vancomycin dosing guidelines recommend targeting trough concentrations of 15-20 mg/L in complicated infections to avoid treatment failure and resistance. How to accomplish this in the intermittent hemodialysis (IHD) population has not been adequately described. A weight-based vancomycin dosing protocol for IHD patients was developed to provide standardization of vancomycin dosing for this patient population. Prior to implementation of this protocol, clinical pharmacists used their individual judgment for dosing and monitoring...
October 19, 2016: Renal Failure
Vaidas Vicka, Laurynas Rimsevicius, Alvita Gincaite, Diana Sukackiene, Marius Miglinas
OBJECTIVE: Water balance and blood pressure (BP) alterations are strongly associated in haemodialysis (HD) patients. Aim of this study was to determine whether bioelectrical impedance analysis (BIA) parameters can be used as predictors of intradialytic hypotension (IDH). DESIGN AND METHOD: We conducted an observational study of chronic HD patients. BIA was measured before the HD procedure using InBody S10 (Biospace, Seoul, Korea) body composition analyzer. Intracellular water (ICW), extracellular water (ECW), total body water (TBW), ECW/TBW ratio and phase angle (PhA) were selected as markers of hydration state and thus possible predictors of IDH...
September 2016: Journal of Hypertension
Deguang Yang, Jinhong Wang, Meng Xiao, Tao Zhou, Xu Shi
Stem-cell-based therapy for cardiovascular disease, especially ischemic heart disease (IHD), is a promising approach to facilitating neovascularization through the migration of stem cells to the ischemic site and their subsequent differentiation into endothelial cells (ECs). Hypoxia is a chief feature of IHD and the stem cell niche. However, whether hypoxia promotes stem cell differentiation into ECs or causes them to retain their stemness is controversial. Here, the differentiation of pluripotent stem cells (iPSCs) into endothelial cells (ECs) was induced under hypoxia...
October 12, 2016: Scientific Reports
Yoo Jee Hee, Chang Seok Bang, Gwang Ho Baik, In Soo Shin, Ki Tae Suk, Tae Young Park, Dong Joon Kim
PURPOSE: Colorectal neoplasm and ischemic heart disease (IHD) share common risk factors. However, clinical guidance about screening or surveillance of colorectal neoplasm in patients with IHD has not been made. The aim of this study was to investigate the relationship between IHD and the development of colorectal neoplasm. METHODS: A systematic literature review was conducted using the core databases (MEDLINE through PubMed, EMBASE, and the Cochrane Library). The data about the association between IHD and the development of colorectal neoplasm were extracted and analyzed using odds ratio (OR)...
2016: SpringerPlus
Masanori Kuwabara, Fumiaki Kondo, Tomoyuki Hamada, Jun-Ichi Takahashi, Nanae Takenaka, Takashi Furuno
BACKGROUND: The objective of this study was to determine whether the use of statins prevents the progression of ischemic heart disease (IHD) in patients with low levels of low-density lipoprotein cholesterol (LDL-C). METHODS: We reviewed data obtained from IHD patients who underwent first percutaneous coronary intervention (PCI). Patients underwent follow-up coronary angiography (re-CAG) after PCI. However, only patients with LDL-C levels less than 100 mg/dL at PCI were included in this study...
September 2016: Acta Cardiol Sin
Enrique López, Alexander J Steiner, Kimberly Smith, Nicholas S Thaler, David J Hardy, Andrew J Levine, Hussah T Al-Kharafi, Cristina Yamakawa, Karl Goodkin
Given that neurocognitive impairment is a frequent complication of HIV-1 infection in Spanish-speaking adults, the limited number of studies assessing HIV-associated neurocognitive disorders (HAND) in this population raises serious clinical concern. In addition to being appropriately translated, instruments need to be modified, normed, and validated accordingly. The purpose of the current study was to examine the diagnostic utility of the HIV Dementia Scale (HDS) and International HIV Dementia Scale (IHDS) to screen for HAND in Spanish-speaking adults living with HIV infection...
August 15, 2016: Applied Neuropsychology. Adult
Don Ihde
As a long-time scholar of science and art practices, I look particularly at the role of tools and instruments which make these practices possible. I note that science, historically, has favoured visualist imaging, but art, particularly in performance modes, often uses acoustic imaging. Early modern science was dominantly optical in instrumentation, but uses of optics often preceded science use in early modern times. In late modern times, much more complex instrumentation often originated in the sciences, but artists frequently adapted to acoustic practices...
October 3, 2016: Nursing Philosophy: An International Journal for Healthcare Professionals
Qin Xu, Shuo Wang, Yuming Guo, Chao Wang, Fangfang Huang, Xia Li, Qi Gao, Lijuan Wu, Lixin Tao, Jin Guo, Wei Wang, Xiuhua Guo
Fine particulate matter (PM2.5) air pollution outbreaks have recently occurred frequently in China. However, evidence of the associations between short-term exposure to PM2.5 and cardiovascular morbidity is still limited in China. This study aimed to evaluate the associations between PM2.5 and hospital emergency room visits (ERVs) for cardiovascular diseases in urban areas in Beijing. Daily counts of cardiovascular ERVs were collected from ten large general hospitals from Jan 1 to Dec 31, 2013. Air pollution data were obtained from the Beijing Environmental Protection Bureau including 17 monitoring stations...
September 30, 2016: Environmental Pollution
Carmen Pizarro, Neele Herweg-Steffens, Martin Buchenroth, Wolfgang Schulte, Christian Schaefer, Christoph Hammerstingl, Nikos Werner, Georg Nickenig, Dirk Skowasch
BACKGROUND: In acute exacerbation of COPD, increased plasma levels of cardiac troponin are frequent and associated with increased mortality. Thus, we aimed at prospectively determining the diagnostic value of coronary angiography in patients with exacerbated COPD and concomitantly elevated cardiac troponin. PATIENTS AND METHODS: A total of 88 patients (mean age 72.9±9.2 years, 56.8% male) hospitalized for acute exacerbation of COPD with elevated plasma troponin were included...
2016: International Journal of Chronic Obstructive Pulmonary Disease
Xiaoming Yuan, Guangrong Zhou, Yan He, Aiwen Feng
BACKGROUND: Epithelial dysplasia and adenomatous polyps of colorectum are precancerous lesions. Surgical removal is still one of the important treatment approaches for colorectal polyps. CASE PRESENTATION: A male patient over 78 years was admitted due to bloody stool and abdominal pain. Colonoscopic biopsy showed a high-grade epithelial dysplasia in an adenomatous polyp of sigmoid colon. Anemia, COPD, ischemic heart disease (IHD), arrhythmias, and hypoproteinemia were comorbidities...
September 26, 2016: World Journal of Surgical Oncology
Ibrahim Toprak, Volkan Yaylali, Cem Yildirim
PURPOSE: To evaluate the effects of pediatric corneal collagen cross-linking (CXL) on corrected distance visual acuity (CDVA), maximum keratometry (Kmax), and other Scheimpflug imaging system parameters during 2 years of follow-up. METHODS: The records of 29 eyes of 29 pediatric patients who underwent unilateral CXL treatment for progressive keratoconus were reviewed. Changes in CDVA, Kmax, anterior chamber depth, anterior chamber volume, anterior chamber angle, pupil-center pachymetry, apical pachymetry, thinnest pachymetry, corneal volume, and topographic indices (index of surface variance [ISV], index of vertical asymmetry [IVA], index of height asymmetry [IHA], keratoconus index [KI], center keratoconus index [CKI], index of height decentration [IHD], and minimum radius of curvature [Rmin]) were analyzed among baseline and 1 and 2 years after the CXL treatment...
September 26, 2016: Journal of Pediatric Ophthalmology and Strabismus
Sung Ill Jang, Jin-Hyeok Hwang, Kwang-Hun Lee, Jeong-Sik Yu, Hee Wook Kim, Chang Jin Yoon, Yoon Suk Lee, Kyu Hyun Paik, Sang Hyub Lee, Dong Ki Lee
BACKGROUND AND AIM: Palliative endoscopic or percutaneous biliary drainage is used for unresectable advanced hilar cancer (HC). The best option for drainage in Bismuth type III or IV HC has not been established. The aims of this study are to identify factors predictive of endoscopic stenting failure and evaluate the effectiveness of rescue percutaneous stenting in patients with advanced HC. METHODS: Data from 110 patients with inoperable advanced HC were retrospectively reviewed...
September 25, 2016: Journal of Gastroenterology and Hepatology
Christopher J McAloon, Luke M Boylan, Thomas Hamborg, Nigel Stallard, Faizel Osman, Phang B Lim, Sajad A Hayat
The pattern and global burden of disease has evolved considerably over the last two decades, from primarily communicable, maternal, and perinatal causes to non-communicable disease (NCD). Cardiovascular disease (CVD) has become the single most important and largest cause of NCD deaths worldwide at over 50%. The World Health Organisation (WHO) estimates that 17.6 million people died of CVD worldwide in 2012. Proportionally, this accounts for an estimated 31.43% of global mortality, with ischaemic heart disease (IHD) accounting for approximately 7...
September 15, 2016: International Journal of Cardiology
Laura Alston, Steven Allender, Karen Peterson, Jane Jacobs, Melanie Nichols
OBJECTIVE: To summarise all available evidence on the differences in burden of ischaemic heart disease (IHD) between metropolitan and rural communities of Australia. METHODS: Systematic review of peer-reviewed literature published between 1990 and 2014. Search terms were derived from the four major topics: (1) rural; (2) ischaemic heart disease; (3) Australia; and (4) burden of disease. Terms were adapted for six databases and two independent researchers screened results...
August 22, 2016: Heart, Lung & Circulation
Isabelle Johansson, Ulf Dahlström, Magnus Edner, Per Näsman, Lars Rydén, Anna Norhammar
BACKGROUND: Heart failure (HF) is a common and serious complication in type 2 diabetes mellitus (T2DM). The prognosis of ischemic HF and impact of revascularization in such patients have not been investigated fully in a patient population representing everyday practice. OBJECTIVES: This study examined the impact of ischemic versus nonischemic HF and previous revascularization on long-term prognosis in an unselected population of patients with and without T2DM. METHODS: Patients stratified by diabetes status and ischemic or nonischemic HF and history of revascularization in the Swedish Heart Failure Registry (SwedeHF) from 2003 to 2011 were followed up for mortality predictors and longevity...
September 27, 2016: Journal of the American College of Cardiology
Yu-Yen Chen, Hsiao-Yun Hu, Dachen Chu, Hsin-Hua Chen, Chin-Kuo Chang, Pesus Chou
OBJECTIVES: To investigate whether patients with primary open angle glaucoma (POAG) have a higher proportion of ischemic heart disease (IHD) development. DESIGN: A population-based retrospective cohort study, using the National Health Insurance Database (NHID) from 1st January, 2001, to 31st December, 2011, in Taiwan. METHODS: 3510 subjects with POAG were enrolled into the POAG group and 14040 subjects without glaucoma into the comparison group...
2016: PloS One
Rifat Atun, Ipek Gurol-Urganci, Thomas Hone, Lisa Pell, Jonathan Stokes, Triin Habicht, Kaija Lukka, Elin Raaper, Jarno Habicht
BACKGROUND: Following independence from the Soviet Union in 1991, Estonia introduced a national insurance system, consolidated the number of health care providers, and introduced family medicine centred primary health care (PHC) to strengthen the health system. METHODS: Using routinely collected health billing records for 2005-2012, we examine health system utilisation for seven ambulatory care sensitive conditions (ACSCs) (asthma, chronic obstructive pulmonary disease [COPD], depression, Type 2 diabetes, heart failure, hypertension, and ischemic heart disease [IHD]), and by patient characteristics (gender, age, and number of co-morbidities)...
December 2016: Journal of Global Health
Vaidas Vicka, Laurynas Rimsevicius, Alvita Gincaite, Diana Sukackiene, Marius Miglinas
OBJECTIVE: Water balance and blood pressure (BP) alterations are strongly associated in haemodialysis (HD) patients. Aim of this study was to determine whether bioelectrical impedance analysis (BIA) parameters can be used as predictors of intradialytic hypotension (IDH). DESIGN AND METHOD: We conducted an observational study of chronic HD patients. BIA was measured before the HD procedure using InBody S10 (Biospace, Seoul, Korea) body composition analyzer. Intracellular water (ICW), extracellular water (ECW), total body water (TBW), ECW/TBW ratio and phase angle (PhA) were selected as markers of hydration state and thus possible predictors of IDH...
September 2016: Journal of Hypertension
C A T Pinheiro, L D M Souza, J V S Motta, E F Kelbert, M S Souza, C S R Martins, F M C Coelho, K A T Pinheiro, R T Pinheiro
Neurocognitive impairment (NCI) is frequently observed in patients infected with human immunodeficiency virus (HIV) and results from the compromise of subcortical brain structures by the virus. The manifestations of NCI range from asymptomatic impairment to dementia. In addition to cognitive impairment resulting from HIV infection, other factors such as depression are associated with the loss of cognitive functions. The aim of this study was to estimate the prevalence of NCI in HIV-positive patients in a city in southern Brazil and to establish possible associations for the prevalence of NCI with HIV-related and other risk factors...
September 12, 2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Jun Yang, Chun-Quan Ou, Yu-Feng Song, Li Li, Ping-Yan Chen, Qi-Yong Liu
Previous studies have mainly used mortality or morbidity as the health outcome to examine the air pollution-health association. Little evidence is available on relationships between air pollutants and years of life lost (YLL). We aimed to estimate the YLL from cardiovascular mortality due to air pollution. Daily data on weather and air pollutants and individual data of all registered deaths for years 2004-2007 were obtained in Guangzhou, China. The generalized additive model was used to assess the YLL associated with 10μg/m(3) increases in NO2, SO2 and PM10...
September 6, 2016: Science of the Total Environment
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