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Paolo Severino, Andrea D'Amato, Lucrezia Netti, Mariateresa Pucci, Marialaura De Marchis, Raffaele Palmirotta, Maurizio Volterrani, Massimo Mancone, Francesco Fedele
Diabetes mellitus is one the strongest risk factors for cardiovascular disease and, in particular, for ischemic heart disease (IHD). The pathophysiology of myocardial ischemia in diabetic patients is complex and not fully understood: some diabetic patients have mainly coronary stenosis obstructing blood flow to the myocardium; others present with coronary microvascular disease with an absence of plaques in the epicardial vessels. Ion channels acting in the cross-talk between the myocardial energy state and coronary blood flow may play a role in the pathophysiology of IHD in diabetic patients...
March 10, 2018: International Journal of Molecular Sciences
Angela L Chiew, Daniel F B Wright, Nicola M Dobos, Kylie McArdle, Ahmed A Mostafa, Annemarie Newth, Michael S Roberts, Geoffrey K Isbister
Massive metformin overdose can cause metabolic acidosis with hyperlactatemia. A 55-year-old female presented 5h post multi-drug overdose, including 132 g extended-release metformin. Continuous venovenous haemodiafiltration (CVVHDF) and noradrenaline were commenced due to metabolic acidosis (pH 7.0, lactate 17 mmol/L) and shock. Despite 3 hours of CVVHDF, her acidosis worsened (pH 6.83, lactate 24 mmol/L). Intermittent haemodialysis(IHD) improved acidosis (pH 7.13, lactate 26 mmol/l), but again worsened (pH 6...
March 13, 2018: British Journal of Clinical Pharmacology
Itismita Mohanty, Tesfaye Alemayehu Gebremedhin
This paper examines the effect of maternal socio-economic status in the household, such as their autonomy, ability, freedom and bargaining power, on child birth registration in India using the nationally representative India Human Development Survey-II (IHDS-II), 2011-12. We have estimated a multilevel mixed effects model which accounts for the hierarchical structure of the data and allows us to examine the effects of unobserved 'district' and 'community' characteristics along with individual child level characteristics on probability of birth registration...
2018: PloS One
Jing Huang, Guoxing Li, Xujun Qian, Guozhang Xu, Yan Zhao, Jian Huang, Qichen Liu, Tianfeng He, Xinbiao Guo
OBJECTIVE: Air pollution is considered one of the most important risk factors for ischemic heart disease (IHD), which is a major public health concern. The disease burden of IHD has continued to rise in China in the past two decades. However, epidemiological studies examining the associations between air pollution and IHD have been scarce in China, and the only studies were conducted in severe air pollution areas, where air pollution levels seriously exceed the World Health Organization Air Quality Guidelines...
March 7, 2018: Environmental Research
Tatiana Vagašová, Beáta Gavurová
AIM: The purpose of this paper is to determine how many years a person could be expected to live if a specific cause of death was eliminated, and to compare potential gains in life expectancy (PGLEs) between Slovakia (SVK) and the Czech Republic (CZE). METHODS: PGLEs were computed from mortality reports (1996-2013) for deaths from the main groups of chronic diseases, namely ischaemic heart disease (IHD), cerebrovascular diseases (CVD), cancer (CA), diabetes mellitus (DM), and chronic respiratory diseases (CRD) for the Slovak and Czech populations in five-year age groups...
December 2017: Central European Journal of Public Health
Yutong Cai, Susan Hodgson, Marta Blangiardo, John Gulliver, David Morley, Daniela Fecht, Danielle Vienneau, Kees de Hoogh, Tim Key, Kristian Hveem, Paul Elliott, Anna L Hansell
BACKGROUND: This study aimed to investigate the effects of long-term exposure to road traffic noise and air pollution on incident cardiovascular disease (CVD) in three large cohorts: HUNT, EPIC-Oxford and UK Biobank. METHODS: In pooled complete-case sample of the three cohorts from Norway and the United Kingdom (N = 355,732), 21,081 incident all CVD cases including 5259 ischemic heart disease (IHD) and 2871 cerebrovascular cases were ascertained between baseline (1993-2010) and end of follow-up (2008-2013) through medical record linkage...
March 5, 2018: Environment International
Niti R Aggarwal, Rachel M Bond, Jennifer H Mieres
Substantial advances and insights in medical technology and treatment strategies, and the focus on sex-specific research have contributed to a reduction in cardiovascular mortality in women. Despite these advances, ischemic heart disease (IHD) remains the leading cause of cardiovascular morbidity and mortality of women in the Western world. Advances in cardiovascular imaging, over the past 4 decades, have significantly improved the evaluation and management of the full spectrum of coronary atherosclerosis, which contributes to ischemic heart disease...
March 5, 2018: Clinical Cardiology
Debasis Barik, Sonalde Desai, Reeve Vanneman
Research on economic status and adult mortality is often stymied by the reciprocity of this relationship and lack of clarity on which aspect of economic status matters. While financial resources increase access to healthcare and nutrition and reduce mortality, sickness also reduces labor force participation, thereby reducing income. Without longitudinal data, it is difficult to study the linkage between economic status and mortality. Using data from a national sample of 132,116 Indian adults aged 15 years and above, this paper examines their likelihood of death between wave 1 of the India Human Development Survey (IHDS), conducted in 2004-2005 and wave 2, conducted in 2011-2012...
March 2018: World Development
Christine Pacheco Claudio, Odayme Quesada, Carl J Pepine, C Noel Bairey Merz
The syndromes of myocardial infarction/myocardial ischemia with No Obstructive Coronary Artery Disease (MINOCA/INOCA) are increasingly evident. A majority of these patients have coronary microvascular dysfunction. These patients have elevated risk for a cardiovascular event (including acute coronary syndrome, myocardial infarction, stroke, and repeated cardiovascular procedures) and appear to be at higher risk for development of heart failure with preserved ejection fraction. Terminology such as coronary artery disease or coronary heart disease is often synonymous with obstructive atherosclerosis in the clinician's mind, leaving one at a loss to recognize or explain the phenomenon of MINOCA and INOCA with elevated risk...
March 2, 2018: Clinical Cardiology
J H Si, R R Meng, C Q Yu, Y Guo, Z Bian, Y L Tan, P Pei, J S Chen, Z M Chen, J Lyu, L M Li
Objective: To evaluate the association of family history with risk of major coronary events (MCE) and ischemic heart disease (IHD). Methods: After excluding participants with heart disease, stroke or cancer at baseline survey, a total of 485 784 participants from the China Kadoorie Biobank, who had no missing data on critical variables, were included in the analysis. Cox regression analysis was used to estimate the hazard ratios ( HR ) and 95% CI . Subgroup analyses were performed according to the baseline characteristics...
February 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
T V Azizova, E Batistatou, E S Grigorieva, R McNamee, R Wakeford, H Liu, F de Vocht, R M Agius
Mortality from circulatory disease (CD), ischemic heart disease (IHD) and cerebrovascular disease (CeVD) was investigated in relationship to cumulative doses of external gamma radiation and internal alpha radiation to the liver from deposited plutonium over long follow-up periods in two large cohorts of nuclear workers: the Russian Mayak Worker Cohort (MWC) and the UK Sellafield Worker Cohort (SWC). The MWC comprised 22,374 workers (74.6% males) with 5,123 CD deaths registered during 842,538 person-years of follow-up, while the SWC comprised 23,443 workers (87...
March 1, 2018: Radiation Research
J Paccou, S D'Angelo, A Rhodes, E M Curtis, Z Raisi-Estabragh, M Edwards, K Walker-Bone, C Cooper, S E Petersen, N C Harvey
In the large UK Biobank population-based cohort, we found that amongst men, but not women, prior fragility fracture was associated with increased risk of admission with ischaemic heart disease. INTRODUCTION: We aimed to investigate the relationship between prior fracture and risk of incident ischaemic cardiovascular events in a UK population-based cohort. METHODS: UK Biobank is a large prospective cohort comprising 502,637 men and women aged 40-69 years, with detailed baseline assessment...
February 26, 2018: Osteoporosis International
Sasan Faridi, Mansour Shamsipour, Michal Krzyzanowski, Nino Künzli, Heresh Amini, Faramarz Azimi, Mazen Malkawi, Fatemeh Momeniha, Akbar Gholampour, Mohammad Sadegh Hassanvand, Kazem Naddafi
The main objectives of this study were (1) investigation of the temporal variations of ambient fine particulate matter (PM2.5 ) and ground level ozone (O3 ) concentrations in Tehran megacity, the capital and most populous city in Iran, over a 10-year period from 2006 to 2015, and (2) estimation of their long-term health effects including all-cause and cause-specific mortality. For the first goal, the data of PM2.5 and O3 concentrations, measured at 21 regulatory monitoring network stations in Tehran, were obtained and the temporal trends were investigated...
February 21, 2018: Environment International
Luan Luan, Hao Hu, Shu-Chuen Li
OBJECTIVES: To review published studies of the use of health-related quality-of-life (HRQOL) instruments in patients with ischemic heart disease (IHD) in Chinese-speaking countries/regions, namely, mainland China, Hong Kong, Taiwan, and Singapore. METHODS: Overlapping searching strategy was used for searching three electronic databases-Cochrane Library, MEDLINE, and Embase-from January 1, 1990, to September 30, 2015. After culling, the identified publications were analyzed according to the publication date, the location where the study was conducted, the disease being studied, and the nature of the study (i...
October 18, 2017: Value in Health Regional Issues
Michal Vinker Shuster, Omer Gendelman, Shmuel Tiosano, Doron Comaneshter, Arnon D Cohen, Howard Amital
To assess the association of ankylosing spondylitis (AS) and ischemic heart disease (IHD) compared to traditional cardiovascular (CV) risk factors. Primary care and hospital records of patients with AS were analyzed, using the largest health maintenance organization in Israel, the "Clalit" Health Services data. These patients were compared with age- and gender-matched controls regarding the proportion of IHD in a cross-sectional study. Parameters including socioeconomic status, body mass index (BMI), smoking habits, and coexistent medical conditions hypertension, hyperlipidemia, and diabetes mellitus (DM) - as well as the use of NSAIDs and anti-TNFs were also assessed...
February 22, 2018: Clinical Rheumatology
Elise van Kempen, Maribel Casas, Göran Pershagen, Maria Foraster
To update the current state of evidence and assess its quality, we conducted a systematic review on the effects of environmental noise exposure on the cardio-metabolic systems as input for the new WHO environmental noise guidelines for the European Region. We identified 600 references relating to studies on effects of noise from road, rail and air traffic, and wind turbines on the cardio-metabolic system, published between January 2000 and August 2015. Only 61 studies, investigating different end points, included information enabling estimation of exposure response relationships...
February 22, 2018: International Journal of Environmental Research and Public Health
K Takada, C A Palm, S E Epstein, L D Cowgill
BACKGROUND: Renal replacement therapies can be life-saving for dogs with severe acute kidney injury (AKI), however, comorbidities including pancreatitis might affect outcome. HYPOTHESIS/OBJECTIVES: To investigate the prevalence of pancreas-specific lipase (Spec cPL) measurements consistent with pancreatitis (≥400 μg/L) in dogs undergoing intermittent hemodialysis (IHD) for treatment of AKI and to determine whether there were associations between 30-days outcomes and Spec cPL measurements...
February 22, 2018: Journal of Veterinary Internal Medicine
E Z Golukhova, O I Gromova, N I Bulaeva, L A Bokeria
Ischemic heart disease (IHD) and acute coronary syndrome are the main cause of sudden cardiac death (SCD). Incidence of SCD in patients after myocardial infarction (MI) is 4-6-fold higher than in general population. The review focuses on electrophysiological changes during acute myocardial ischemia and mechanisms of myocardial electromechanical remodeling in remote period after MI. Current data on arrhythmia substrates and triggers are presented. Nowadays, the main guide for implantable cardioverter-defibrillator (ICD) use for primary prevention of SCD is reduced left ventricular ejection fraction...
December 2017: Kardiologiia
S A Shalnova, A E Imaeva, A D Deev, V A Metelskaya, G A Muromtseva, A O Konradi, V P Masenko, A Y Efanov, N V Kulakova, O P Rotar, I A Trubacheva, A A Shabunova, E V SHlyakhto, S A Boytsov
AIM: to study associations between elevated blood plasma concentration of N-terminal pro-brain natriuretic peptide (NT-proBNP), risk factors and cardiovascular diseases (CVD) in samples of adult population of Russian Federation (RF) aged 25-64 years. MATERIALS AND METHODS: We analyzed data of examination of representative samples of population of 5 regions of RF obtained within the framework of the multicenter ESSE-RF study (2012-2013). Number of examined subjects was 8 077 (3 176 men)...
December 2017: Kardiologiia
V Y Kaplunova, G A SHakaryants, M V Kozhevnikova, I S Ilgisonis, E V Privalova, N V Khabarova, Y I Naymann, Y N Belenkov, V A Shakaryants
The issues of epidemiology and pathophysiology of hypertrophic cardiomyopathy (HCMP), as well as the search for its additional clinical-instrumental and genetic markers, environmental factors capable to influence the formation of its clinical variant and prognosis are subjects of great interest to the modern scientific community. Besides genetic markers of main neurohumoral systems, and morphofunctional parameters of intracardiac hemodynamics clinical course of the disease is influenced by a complex of concomitant pathology including ischemic heart disease (IHD), joining of which is possible in 10% of cases...
December 2017: Kardiologiia
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