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https://www.readbyqxmd.com/read/28319824/effect-of-long-term-remote-ischaemic-conditioning-on-platelet-function-and-fibrinolysis-in-patients-with-chronic-ischaemic-heart-failure
#1
Kasper Pryds, Jacobina Kristiansen, Søs Neergaard-Petersen, Roni R Nielsen, Michael R Schmidt, Jens Refsgaard, Steen D Kristensen, Hans Erik Bøtker, Anne-Mette Hvas, Erik L Grove
INTRODUCTION: Remote ischaemic conditioning (RIC) protects against ischaemia-reperfusion injury through cellular protective pathways, but may also modulate haemostasis. We aimed to investigate the effect of long-term RIC on platelet function and fibrinolysis in patients with chronic ischaemic heart failure (CIHF). MATERIAL AND METHODS: In a prospective, outcome-assessor blinded, paired study, 16 patients with CIHF and 21 age- and gender-matched controls without ischaemic heart disease (IHD) were treated with RIC once daily for 28±4days...
March 10, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28318855/disability-adjusted-life-years-lost-due-to-ischemic-heart-disease-in-mainland-portugal-2013
#2
Ana Henriques, Carla Araújo, Marta Viana, Olga Laszczynska, Marta Pereira, Kathleen Bennett, Nuno Lunet, Ana Azevedo
INTRODUCTION AND OBJECTIVES: Estimates of the burden of ischemic heart disease (IHD), including geographic differences, should support health policy decisions. We set out to estimate the burden of IHD in mainland Portugal in 2013 by calculating disability-adjusted life years (DALYs) and to compare this burden between five regions. METHODS: Years of life lost (YLLs) were calculated by multiplying the number of IHD deaths in 2013 (Statistics Portugal) by the life expectancy at the age at which death occurred...
March 16, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28306758/the-association-between-blood-lead-levels-and-cardiovascular-diseases-among-lead-exposed-male-workers
#3
Young-Sun Min, Yeon-Soon Ahn
Objective We prospectively evaluated the association between blood lead levels (BLL) and increases in hospital admissions for treatment of cardiovascular diseases among lead-exposed workers in Korea. Methods The study cohort was derived from Korea Occupational Safety and Health Agency data, which included lead-exposed male workers who underwent lead-associated medical check-ups at least once between 2000 and 2004. The hospital adjusted admission hazard ratio (AHR) of cardiovascular diseases for each BLL grade (10-20 and ≥20 μg/dL) was compared with that of the reference grade (<10 μg/dL) using Cox's proportional hazard models...
March 17, 2017: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/28306144/exclusion-of-elderly-people-from-randomized-clinical-trials-of-drugs-for-ischemic-heart-disease
#4
Florence T Bourgeois, Liat Orenstein, Sarita Ballakur, Kenneth D Mandl, John P A Ioannidis
OBJECTIVES: To measure exclusion of elderly adults from randomized trials studying drug interventions for ischemic heart disease (IHD) and describe the characteristics of these trials. DESIGN: Cross-sectional analysis. SETTING: Interventional clinical trials studying a drug intervention for IHD that started in 2006 and after were identified in ClinicalTrials.gov. Data were extracted on study features, including age-based inclusion criteria...
March 17, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28301565/parallel-comparison-of-risk-factors-between-progression-of-organic-stenosis-in-the-coronary-arteries-and-onset-of-acute-coronary-syndrome-by-covariance-structure-analysis
#5
Kazuo Ogawa, Kosuke Minai, Makoto Kawai, Toshikazu Tanaka, Tomohisa Nagoshi, Takayuki Ogawa, Michihiro Yoshimura
BACKGROUND: It is widely accepted that progression of organic stenosis in the coronary arteries and onset of acute coronary syndrome (ACS) are similar in the development of atherosclerosis. However, the extent of the association of each risk factor with the respective pathological conditions has not been fully elucidated. OBJECTIVES: We investigated the differences in risk factors between these conditions using a statistical procedure. METHODS: The study population consisted of 1,029 patients with ischemic heart disease (IHD)...
2017: PloS One
https://www.readbyqxmd.com/read/28298952/insights-for-oxidative-stress-and-mtor-signaling-in-myocardial-ischemia-reperfusion-injury-under-diabetes
#6
REVIEW
Dajun Zhao, Jian Yang, Lifang Yang
Diabetes mellitus (DM) displays a high morbidity. The diabetic heart is susceptible to myocardial ischemia/reperfusion (MI/R) injury. Impaired activation of prosurvival pathways, endoplasmic reticulum (ER) stress, increased basal oxidative state, and decreased antioxidant defense and autophagy may render diabetic hearts more vulnerable to MI/R injury. Oxidative stress and mTOR signaling crucially regulate cardiometabolism, affecting MI/R injury under diabetes. Producing reactive oxygen species (ROS) and reactive nitrogen species (RNS), uncoupling nitric oxide synthase (NOS), and disturbing the mitochondrial quality control may be three major mechanisms of oxidative stress...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28294880/-results-of-monitoring-of-the-plan-of-measures-directed-to-reduction-of-ischemic-heart-disease-in-north-caucasus-republics-analysis-of-dynamics-of-cardio-vascular-mortality
#7
M N Mamedov
Comparative analysis of dynamics of cardiovascular mortality in Russia and foreign countries as well as main directions of development of cardiological service in Russia are presented in this review article. Plan of measures for reduction of mortality from ischemic heart disease (IHD) was created in 2015. This plan comprises 4 blocks of assessment of the following measures: directed at improvement of primary IHD prevention (1), directed at secondary prevention of complications of IHD (2); directed at improvement of efficacy of medical care of patients with IHD (3), and directed at monitoring of some demographic parameters (4)...
May 2016: Kardiologiia
https://www.readbyqxmd.com/read/28294868/-rosuvastatin-in-coronary-bypass-surgery-whether-only-secondary-prevention
#8
A V Panov, M L Gordeev, L B Mitrofanova, E V Kuleshov, M I Buthashvili, I T Abesadze, M Z Alugishvili, N L Lohovinina, K V Korzhenevskaya
BACKGROUND AND AIM: The increasing number of coronary artery bypass grafting (CABG) is associated with a need for active introduction of methods improving immediate and long-term results of these interventions. Results of a number of studies conducted during recent years allow to consider high dose statin therapy one of such methods. In this article we present results of rosuvastatin administration to patients with ischemic heart disease (IHD) prior to surgery. METHODS: Rosuvastatin (40 mg/day) was given for 4 weeks before CABG to patients who had previously taken simvastatin (20 mg/day)...
May 2016: Kardiologiia
https://www.readbyqxmd.com/read/28294866/-treatment-of-patients-with-stable-ischemic-heart-disease-in-real-clinical-practice-in-russia-the-choice-2-program
#9
G Glezer M, On Behalf Of The Choice-Study Participants On Behalf Of The Choice-Study Participants
OBJECTIVE: in the framework of an open post-marketing observational national program CHOICE-2 to assess correspondence between recommendations for management of patients with stable angina and actual clinical practice, as well as to assess effect of treatment with cytoprotector trimetazidine on clinical course of the disease. MATERIAL AND METHODS: Participating physicians (n=185 from 46 regions of Russian Federation) recruited 896 patients with ischemic heart disease (IHD)...
May 2016: Kardiologiia
https://www.readbyqxmd.com/read/28294862/-revascularization-in-stable-ischemic-heart-disease-whether-to-change-the-approach
#10
L L Bershtein, N O Katamadze, A E Golovina, S A Sayganov
Current international guidelines on stable ischemic heart disease (IHD) state that coronary revascularization is indicated in cases of: limiting ischemic symptoms while on optimal medical therapy (OMT); high risk coronary anatomy; high risk stress test result. At the same time, many results supporting these conclusions were obtained in relatively old studies, conducted when the approaches to medical therapy and revascularization techniques differed greatly from contemporary practice. Many of the conclusions have been based on data from observational studies and subanalyses of randomized clinical trials, therefore methodologically are not sufficiently reliable...
April 2016: Kardiologiia
https://www.readbyqxmd.com/read/28294853/-interrelation-of-electrophysiological-and-perfusion-changes-in-patients-with-left-ventricular-aneurysm
#11
V E Babokin, V M Shipulin, S M Minin, R E Batalov, S S Gutor, U B Lishmanov, S V Popov, V N Ilyinov, S L Andreev, R S Karpov
The study was aimed at identification of relations between perfusion and electrophysiological changes in left ventricular (LV) myocardium in patients with ischemic heart disease (IHD) with postinfarction LV aneurysm and ventricular tachycardia. The study enrolled 23 patients with the aforementioned disease. Preoperatively, apart from standard clinical examination of cardiosurgical patients, intracardiac electrophysiological study and perfusion single-photon emission computed tomography of myocardium with 99mTc-Technetril were performed...
April 2016: Kardiologiia
https://www.readbyqxmd.com/read/28292203/simple-screening-for-neurocognitive-impairment-in-routine-hiv-outpatient-care-is-it-deliverable
#12
Sarah Parry, Sarah Zetler, Anna Kentridge, Jenny Petrak, Tristan Barber
Routine screening for psychological and cognitive difficulties is recommended in BHIVA guidelines but screening questions are not specified and studies give varied recommendations. Our aim was to see if simple screening in the routine clinic could help better direct our referrals to psychology and highlight those patients requiring, and likely to benefit from, further assessment. We introduced brief questions to assess neurocognitive impairment (NCI) and mood into routine HIV visits, with an onward referral pathway for further investigation for those screening positive...
March 14, 2017: AIDS Care
https://www.readbyqxmd.com/read/28291652/cost-effectiveness-of-hospital-treatment-and-outcomes-of-acute-methanol-poisoning-during-the-czech-republic-mass-poisoning-outbreak
#13
Jan Rulisek, Martin Balik, Ferdinand Polak, Petr Waldauf, Daniela Pelclova, Jan Belohlavek, Sergey Zakharov
PURPOSE: During an outbreak of mass methanol poisoning in the Czech Republic in 2012-2014, we compared the total hospital costs and one-year medical costs in the patients treated with different antidotes (fomepizole versus ethanol) and modalities of hemodialysis (intermittent hemodialysis, IHD, versus continuous renal replacement therapy, CRRT). METHODS: Cross-sectional study in 106 patients with confirmed diagnosis treated in 30 ICU settings. For each patient, the following data were analyzed: admission laboratory data, GCS, PSS, ICU length of stay, organ failures, treatment, outcome, and total hospital costs...
March 6, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28290910/-the-results-of-the-method-percutaneous-intracoronary-intervention-in-patients-of-both-male-and-female
#14
V A Kuznetsov, G S Pushkarev, E I I, I S Bessonov, D V Krinochkin, E V Akimova
OBJECTIVE: To assess gender differences among patients subjected to percutaneous coronary intervention (PCI) according to data of the "Register of performed operations of percutaneous transluminal coronary angioplasty (PTCA)". MATERIALS AND METHODS: The Register was conducted from 1996 to 2012 years and comprised 4890 patients (4121 men and 769 women). RESULTS: Women compared to men were older (58.2+/-8.6 vs 53.4+/-8.3 years; <0.001), had higher body mass index (31...
July 2016: Kardiologiia
https://www.readbyqxmd.com/read/28290905/-therapy-of-high-risk-patients-after-decompensation-of-heart-failure-under-nt-probnp-control-main-results
#15
A A Skvortsov, D E Koshkina, O Yu Narusov, V N Protasov, V P Masenko, S N Tereshchenko
AIM: to compare efficacy of treatment of high risk patients after acute decompensation (AD) of chronic heart failure (CHF) based on monitoring of NT-proBNP concentration and standard treatment. MATERIAL AND METHODS: Patients (n=100) with class III-IV CHF and left ventricular ejection fraction (LV EF) <40% due to ischemic heart disease (IHD), dilated cardiomyopathy (DCMP), or arterial hypertension (AH) after compensation of HF before discharge were distributed into groups of low (NT-proBNP <1400 picog/ml, n=30) or high (NT-proBNP more or equal 1400 picog/ml, n=70) risk...
July 2016: Kardiologiia
https://www.readbyqxmd.com/read/28290902/-interaction-between-personality-pain-and-genes-in-ischemic-heart-disease
#16
V E Golimbet, B A Volel, S N Enikopolov, G I Korovaytseva, F Yu Kopulov
Personality traits of the patient with ischemic heart disease (IHD) are thought to determine disease course. Their level depends on clinical presentations of IHD including the presence of cardiac pain. The aim of the study was to identify the modifying effect of genes coding for serotonin transporter (5-HTTLPR), serotonin receptor type 2A (A-1438G) and 2C (Cys23Ser) as well as brain-derived neurotrophic factor (Val66Met) on personality traits in pain and painless forms of IHD. We found interaction between pain and personality factors mediated by genetic variant...
July 2016: Kardiologiia
https://www.readbyqxmd.com/read/28290892/-comparative-assessment-of-antianginal-efficacy-and-safety-of-nicorandil-at-the-background-of-therapy-with-adrenoblockers-in-ischemic-heart-disease-patients-with-stable-angina
#17
S Yu Martsevitch, N P Kutishenko, A D Deev On Behalf Of The Kvazar Study
AIM: to demonstrate impact of addition of nicorandil to standard treatment in patients with stable ischemic heart disease (IHD) on clinical manifestations of the disease and safety of conducted therapy. MATERIAL AND METHODS: We included in this double-blind placebo controlled study with parallel groups 120 patients with verified IHD and stable effort angina. During the entire study all patients received metoprolol (100 mg/day). Patients of main group were given nicorandil (10 mg twice a day for 2 weeks and 20 mg twice a day thereafter); patients of control group were given placebo...
October 2016: Kardiologiia
https://www.readbyqxmd.com/read/28290891/-the-role-of-urinary-lipocalin-in-prognostication-of-hospital-complications-in-patients-with-ischemic-heart-disease-after-coronary-artery-bypass-grafting
#18
K S Shafranskaya, O K Kuzmina, D A Sumin, K Ye Krivoshapova, Ye G Uchasova, S V Ivanov, M V Zykov, V V Kashtalap, O L Barbarash
PURPOSE: To assess significance of urinary neutrophil gelatinase-associated lipocalin (NGAL) for predicting hospital complications in subjects with ischemic heart disease (IHD) after coronary artery bypass grafting (CABG). MATERIALS AND METHODS: The study included 720 subjects who underwent CABG between 03/2011 and 04/2012. Blood serum creatinine level, glomerular filtration rate (GFR) (MDRD formula) and NGAL concentration were measured before and on day 7 after CABG...
October 2016: Kardiologiia
https://www.readbyqxmd.com/read/28290889/-platelet-metabolism-in-clopidogrel-resistant-and-sensitive-patients-with-ischemic-heart-disease
#19
I Yu Grinshtein, A A Savchenko, Yu I Grinshtein, I V Filonenko, A A Kosinova
OBJECTIVE: to investigate relationship between activity of platelet nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) dependent dehydrogenases in patients with ischemic heart disease (IHD) after coronary artery bypass grafting (CABG) and their sensitivity to clopidogrel. MATERIAL AND METHODS: We studied 51 male patients with chronic IHD before and after CABG. Control group comprised 35 healthy men. In IHD patients spontaneous and induced platelet aggregation was measured by aggregometry before CABG (in 2 weeks after cessation of antiplatelet drugs), after CABG during therapy with clopidogrel (75 mg/day), and in 6 months after surgery...
October 2016: Kardiologiia
https://www.readbyqxmd.com/read/28290884/-the-new-european-questionnaire-for-assessment-of-quality-of-life-of-patients-with-ischemic-heart-disease-heartqol
#20
N V Pogosova, I H Boycharov, O Yu Sokolova, V A Vygodin
Quality of life (QL) of patients with ischemic heart disease (IHD) is a combination symptoms of the disease, physical state, emotional status, and social-laboring functioning. Until recently there were no universal questionnaire allowing to perform comparative analysis of QL of patients with effort angina (EF), survivors of myocardial infarction (MI) and chronic heart failure (CHF). Therefore, European Association of Cardiovascular Prevention and Rehabilitation conducted a study with the aim of developing universal questionnaire for assessment of QL in patients with IHD - HeartQol...
August 2016: Kardiologiia
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