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https://www.readbyqxmd.com/read/28526394/do-high-participation-rates-improve-effects-of-population-based-general-health-checks
#1
A M Bender, T Jørgensen, C Pisinger
The aim is to investigate if the effect of a health check differs between areas with different participation rates. The Inter99 population-based randomized lifestyle intervention study covered 73 areas within the suburbs of Copenhagen, Denmark. Adults aged 30-60years were randomly drawn from a population and were randomized to intervention group (n=11,483) or control group (n=47,122). Participation rates in the health check varied considerably between areas (mean 52%; range 35-85%). In separate survival analyses, area participation rate was included both as a continuous exposure variable and as a categorical variable (tertiles; low: 35-49%, meddle: 50-54%, high: 55-84%)...
May 16, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28525779/systematic-review-and-meta-analysis-of-renal-replacement-therapy-modalities-for-acute-kidney-injury-in-the-intensive-care-unit
#2
Danielle M Nash, Sebastian Przech, Ron Wald, Daria O'Reilly
PURPOSE: To compare clinical outcomes among critically ill adults with acute kidney injury (AKI) treated with continuous renal replacement therapy (CRRT), intermittent hemodialysis (IHD) or sustained low efficiency dialysis (SLED). MATERIALS AND METHODS: We completed a systematic review and meta-analysis of studies published in 2015 or earlier using MEDLINE®, EMBASE®, Cochrane databases and grey literature. Eligible studies included randomized clinical trials (RCTs) or prospective cohort studies comparing outcomes of mortality, dialysis dependence or length of stay among critically ill adults receiving CRRT, IHD or SLED to treat AKI...
May 9, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28511203/-intraindividual-keratoconus-progression
#3
Susanne Goebels, Timo Eppig, Berthold Seitz, Achim Langenbucher
Introduction Keratoconus is a typically bilateral, progressive-extending corneal disease. The aim of this work is to evaluate the intraindividual progression of keratoconus. Patients and Methods This single-center retrospective study of disease progression based on topographic data from non-operated keratoconus patients (n = 48) was examined over a period of two years. Seven topographical keratoconus indices derived from Scheimpflug tomography were used to compare both the initial findings, as well as the progression of the fellow eyes...
May 16, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28511168/-the-nonalcoholic-steatohepatitis-influence-on-the-course-and-progression-of-ischemic-heart-disease
#4
Ігор М Скрипник, Ольга В Щербак, Ганна С Маслова
INTRODUCTION: Nonalcoholic steatohepatitis (NASH) can be considered a risk factor of progression of diseases associated with atherosclerosis, especially ischemic heart disease (IHD) with a high probability of early myocardial infarction (MI). AIM: To study the peculiarities and nature of ischemic heart disease clinical picture in patients with concomitant NASH. MATERIALS AND METHODS: The study involved 58 patients with ischemic heart disease...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28501389/differential-proteome-profile-in-ischemic-heart-disease-prognostic-value-in-chronic-angina-versus-myocardial-infarction-a-proof-of-concept
#5
Francesca Scebba, Massimo Papale, Silvia Rocchiccioli, Nadia Ucciferri, Federico Bigazzi, Tiziana Sampietro, Clara Carpeggiani, Antonio L'Abbate, Flavio Coceani, Debora Angeloni
The initial clinical manifestation of ischemic heart disease (IHD) i.e. unheralded myocardial infarction (MI) versus chronic angina pectoris (AP) is statistically associated with adverse or mild disease progression respectively in the long-term follow-up. Here, we subjected AP and MI patients to blood proteomic analysis by Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (SELDI-TOF-MS) in order to investigate putative new prognostic biomarkers of IHD manifestation. We found several differentially expressed peaks but four of them (4176, 4475, 14,158m/z and 8922m/z for AP and MI, respectively) were most reliable...
May 10, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28495463/development-of-an-animal-model-of-progressive-vaccinia-in-nu-nu-mice-and-the-use-of-bioluminescence-imaging-for-assessment-of-the-efficacy-of-monoclonal-antibodies-against-vaccinial-b5-and-l1-proteins
#6
Marina Zaitseva, Antonia Thomas, Clement A Meseda, Charles Y K Cheung, Claudia G Diaz, Yan Xiang, Shane Crotty, Hana Golding
Bioluminescence imaging (BLI) was used to follow dissemination of recombinant vaccinia virus (VACV) expressing luciferase (IHD-J-Luc) in BALB/c nu/nu mice treated post-challenge with monoclonal antibodies (MAbs) against L1 and B5 VACV proteins in a model of Progressive Vaccinia (PV). Areas Under the flux Curve (AUC) were calculated for viral loads in multiple organs in individual mice. Following scarification with 10(5) pfu, IHD-J-Luc VACV undergoes fast replication at the injection site and disseminates rapidly to the inguinal lymph nodes followed by spleen, liver, and axillary lymph nodes within 2-3 days and before primary lesions are visible at the site of scarification...
May 8, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28490903/cardiovascular-risks-in-smokers-treated-with-nicotine-replacement-therapy-a-historical-cohort-study
#7
Jens Dollerup, Jørgen Vestbo, Tarita Murray-Thomas, Alan Kaplan, Richard J Martin, Emilio Pizzichini, Marcia M M Pizzichini, Anne Burden, Jessica Martin, David B Price
BACKGROUND: Previous research suggests exposure to nicotine replacement therapy (NRT) may be associated with an increased risk of cardiovascular disease (CVD). METHODS: Using data from the United Kingdom's Clinical Practice Research Datalink, this study aimed to evaluate CVD events and survival among individuals who attempted smoking cessation with the support of NRT compared with those aided by smoking cessation advice only. We studied CVD outcomes over 4 and 52 weeks in 50,214 smokers attempting to quit - 33,476 supported by smoking cessation advice and 16,738 with the support of NRT prescribed by their primary care physician...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28484832/accuracy-of-routinely-collected-comorbidity-data-in-patients-undergoing-colectomy-a-retrospective-study
#8
Shahin Hajibandeh, Shahab Hajibandeh, Roger Deering, Dearbhla McEleney, John Guirguis, Sarah Dix, Abdelhakem Sreh, Afsana Kausar
OBJECTIVES: This paper aimed to determine the baseline accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of routinely collected comorbidity data in patients undergoing any types of colectomy. METHODS: All patients aged >18 who underwent right hemicolectomy, left hemicolectomy, sigmoid colectomy, subtotal colectomy, or total colectomy between 1 January 2015 and 1 November 2016 were identified. The following comorbidities were considered: hypertension, ischemic heart disease (IHD), diabetes, asthma, chronic obstructive pulmonary disease (COPD), cerebrovascular disease (CVD), chronic kidney disease (CKD), and hypercholesterolemia...
May 8, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28483630/variability-in-atherosclerotic-disease-progression-within-the-infrainguinal-arterial-circulation-is-dependent-on-both-patient-and-anatomical-factors
#9
Lukasz P Zieliński, Mohammed M Chowdhury, Mathew Carter, Ben P Worsfold, Patrick A Coughlin
BACKGROUND: Studies suggest 25% of patients with symptomatic peripheral arterial disease (PAD) develop symptom progression over time yet there is minimal data related to actual atherosclerotic progression. METHODS: Patients who underwent consecutive duplex imaging of the lower limb arteries, at least 6 months apart with no intervening arterial intervention, were identified. Atherosclerotic burden was determined for both femoropopliteal (FP) and crural (CR) arterial segments utilising the Bollinger score (BoS)...
May 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28481950/manifold-implications-of-obesity-in-ischemic-heart-disease-among-japanese-patients-according-to-covariance-structure-analysis-low-reactivity-of-b-type-natriuretic-peptide-as-an-intervening-risk-factor
#10
Joshi Tsutsumi, Kosuke Minai, Makoto Kawai, Kazuo Ogawa, Yasunori Inoue, Satoshi Morimoto, Toshikazu Tanaka, Tomohisa Nagoshi, Takayuki Ogawa, Michihiro Yoshimura
BACKGROUND/OBJECTIVES: Obesity is believed to be one of the major risk factors for cardiovascular disease in Western countries. However, the effects of obesity should be continuously examined in the Japanese population because the average bodily habitus differs among countries. In this study, we collectively examined the significance of obesity and obesity-triggered risk factors including the low reactivity of B-type natriuretic peptide (BNP), for ischemic heart disease (IHD) in Japanese patients...
2017: PloS One
https://www.readbyqxmd.com/read/28472927/renal-replacement-therapy-in-acute-kidney-injury-from-a-chinese-cross-sectional-study-patient-clinical-socioeconomic-and-health-service-predictors-of-treatment
#11
Fang Wang, Daqing Hong, Yafang Wang, Yunlin Feng, Li Wang, Li Yang
BACKGROUND: Renal replacement therapy (RRT) is important to support critically ill patients with acute kidney injury (AKI). This study, a part of a nation-wide survey for AKI conducted by the ISN AKF 0 by 25 China Consortium, aims to study the current RRT practical situation and problems in China. METHODS: The current study is a part of a nation-wide survey for AKI conducted by ISN AKF 0 by 25 China Consortium. The survey included 44 sites all over the country, including 22 academic hospitals in big cities and 22 local hospitals in smaller cities or rural areas...
May 4, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28470583/interaction-effects-between-hiv-and-aging-on-selective-neurocognitive-impairment
#12
Yingying Ding, Haijiang Lin, Weiwei Shen, Qionghai Wu, Meiyang Gao, Na He
HIV infection and aging are each associated with neurocognitive impairment (NCI). This study examined the combined effects of HIV infection and aging on NCI. We performed a cross-sectional survey among 345 HIV-infected and 345 HIV-uninfected participants aged at least 40 years. The International HIV Dementia Scale (IHDS) and Chinese version of Mini-mental State Examination (MMSE) were administered to screen for NCI. HIV-infected individuals had higher prevalence of NCI than uninfected individuals (46.7% vs 15...
May 3, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/28469120/comparing-indications-for-cardiovascular-admissions-into-a-nigerian-and-an-israeli-hospital
#13
Ogba Joseph Ukpabi, Kelechukwu Uwanurochi
BACKGROUND: Changing epidemiologic profile with increase in cardiovascular risk factors is well documented in literature. Our study sought to see how this is reflected in cardiovascular admissions into medical wards of a Nigerian and an Israeli hospital. OBJECTIVE: To compare the range and pattern of cardiovascular admissions encountered in a Nigerian hospital and an Israel hospital. METHODS: This was a retrospective study of admission records of patients admitted into both Federal Medical Centre (FMC), Umuahia, Abia State, Nigeria, and Sheba Medical Centre, Israel...
April 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/28466756/pulmonary-hospitalizations-and-ischemic-heart-disease-events-in-patients-with-peripheral-artery-disease
#14
Mary McGrae McDermott, Lu Tian, Richard G Wunderink, Ravi Kalhan, Melina R Kibbe, Philip Greenland, Russell Tracy, Lihui Zhao, Kiang Liu, Mark Huffman, John T Wilkins, Yihua Liao, Sanjiv Shah, Donald Lloyd Jones, David Green
The prognostic significance of acute pulmonary events in people with lower extremity peripheral artery disease (PAD) is unknown. We hypothesized that an acute pulmonary event (hospitalization for pneumonia and/or chronic lower respiratory disease (CLRD) exacerbation) would be associated with a higher rate of subsequent ischemic heart disease (IHD) events in PAD. A total of 569 PAD participants were systematically identified from among patients in Chicago medical practices and followed longitudinally. Hospitalizations after enrollment were evaluated and adjudicated for pulmonary events...
December 1, 2016: Vascular Medicine
https://www.readbyqxmd.com/read/28466536/a-retrospective-analysis-of-3954-patients-in-phase-2-3-trials-of-bortezomib-for-the-treatment-of-multiple-myeloma-towards-providing-a-benchmark-for-the-cardiac-safety-profile-of-proteasome-inhibition-in-multiple-myeloma
#15
Jacob P Laubach, Javid J Moslehi, Sanjeev A Francis, Jesús F San Miguel, Pieter Sonneveld, Robert Z Orlowski, Philippe Moreau, Laura Rosiñol, Edward A Faber, Peter Voorhees, Maria-Victoria Mateos, Loreta Marquez, Huaibao Feng, Avinash Desai, Helgi van de Velde, Jennifer Elliott, Hongliang Shi, Edward Dow, Nishith Jobanputra, Dixie-Lee Esseltine, Liviu Niculescu, Kenneth C Anderson, Sagar Lonial, Paul G Richardson
This retrospective analysis aimed to establish the overall cardiac safety profile of bortezomib using patient-level data from one phase 2 and seven phase 3 studies in previously untreated and relapsed/refractory multiple myeloma (MM). Seven clinically relevant primary [congestive heart failure (CHF), arrhythmias, ischaemic heart disease (IHD), cardiac death] and secondary (hypertension, dyspnoea, oedema) cardiac endpoints were defined based on MedDRA v16.0 preferred terms. 2509 bortezomib-treated patients and 1445 patients in non-bortezomib-based control arms were included...
May 3, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28461753/the-changing-trend-of-cardiovascular-disease-and-its-clinical-characteristics-in-ethiopia-hospital-based-observational-study
#16
Yonas Getaye Tefera, Tadesse Melaku Abegaz, Tamrat Befekadu Abebe, Abebe Basazn Mekuria
OBJECTIVE: The aim of this study was to assess the pattern of cardiovascular diseases (CVDs), their clinical characteristics, and associated factors in the outpatient department of the chronic illness clinic of Gondar University Referral Hospital. METHOD: A retrospective cross-sectional study was conducted among patients on follow-up at the outpatient chronic illness clinic of the hospital from October 2010 to October 2015. The source population for the study included patients with a diagnosis of CVD whose medical records have the required socio-demographic information during the study period...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28461005/the-complication-of-hepatic-artery-injuries-of-1-304-percutaneous-transhepatic-biliary-drainage-in-a-single-institute
#17
En-Li Shiau, Huei-Lung Liang, Yih-Huie Lin, Ming-Feng Li, Chia-Ling Chiang, Matt Chiung-Yu Chen, Jer-Shyung Huang, Huay-Ben Pan
PURPOSE: To determine frequency of and assess risk factors for hepatic artery (HA) injury during percutaneous transhepatic biliary drainage (PTBD) and to discuss the technique and report the clinical outcome of embolization for HA injury. MATERIALS AND METHODS: Over a 14-year period (2002-2016), 1,304 PTBD procedures in 920 patients were recorded. The incidence of HA injury was determined, and possible associated risk factors were analyzed. When injury occurred, HA embolization was performed at the site as close to the bleeding point as possible...
April 28, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28460769/premature-coronary-artery-disease-in-india-coronary-artery-disease-in-the-young-cady-registry
#18
S S Iyengar, Rajiv Gupta, Sandhya Ravi, Saral Thangam, Thomas Alexander, C N Manjunath, R Keshava, C B Patil, Annie Sheela, J P S Sawhney
BACKGROUND: Coronary artery disease (CAD) occurs at younger age in India but only a limited number of studies have evaluated risk factors and management status. This is a multisite observational registry to assess risk factors and treatment patterns in young patients presenting with acute coronary syndrome (ACS) and stable ischemic heart disease (IHD). METHODS: We recruited 997 young patients (men <55, women <65y) presenting with ACS or stable IHD successively at 22 centers across India...
March 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28448010/murine-left-anterior-descending-lad-coronary-artery-ligation-an-improved-and-simplified-model-for-myocardial-infarction
#19
Karla Reichert, Bonnie Colantuono, Isabella McCormack, Fernanda Rodrigues, Vasile Pavlov, M Ruhul Abid
Ischemic heart disease (IHD), or acute coronary syndrome (ACS), is one of the leading causes of death in the United States. IHD is characterized by reduced blood supply to the heart, resulting in the loss of oxygen to and the ensuing necrosis of the heart muscle. The MI model has gained popularity for its use as a short-term ischemia-reperfusion model and a long-term permanent ligation model. Below, we describe a reliable method for the permanent ligation of the LAD. With mouse genetic engineering technology becoming more advanced, and with an increasing availability of quality murine surgical instruments, the mouse has become a popular model for MI surgeries...
April 2, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28445425/association-of-long-term-near-highway-exposure-to-ultrafine-particles-with-cardiovascular-diseases-diabetes-and-hypertension
#20
Yu Li, Kevin J Lane, Laura Corlin, Allison P Patton, John L Durant, Mohan Thanikachalam, Mark Woodin, Molin Wang, Doug Brugge
Ultrafine particle (UFP) concentrations are elevated near busy roadways, however, their effects on prevalence of cardiovascular diseases, diabetes, and hypertension are not well understood. To investigate these associations, data on demographics, diseases, medication use, and time of activities were collected by in-home surveys for 704 participants in three pairs of near-highway and urban background neighborhoods in and near Boston (MA, USA). Body mass index (BMI) was measured for a subset of 435 participants...
April 26, 2017: International Journal of Environmental Research and Public Health
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