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https://www.readbyqxmd.com/read/29674361/is-decreased-lung-function-associated-with-chronic-kidney-disease-a-retrospective-cohort-study-in-korea
#1
Soo Kyoung Kim, Ji Cheol Bae, Jong-Ha Baek, Kyu Yeon Hur, Moon-Kyu Lee, Jae Hyeon Kim
OBJECTIVE: There is some evidence that lung function and chronic kidney disease (CKD) may be related. We evaluated the impact of lung function on the development of CKD in a large-scale longitudinal study. METHOD: Retrospective longitudinal analyses were conducted among subjects who participated in comprehensive health check-ups at least four times during 7 years (between 2006 and 2012). We investigated the development of CKD during the follow-up period according to lung function status...
April 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29665969/copeptin-plasma-levels-are-associated-with-decline-of-renal-function-in-patients-with-type-2-diabetes-mellitus
#2
Maria De La Luz Villela-Torres, Ana Edith Higareda-Mendoza, Anel Gómez-García, Alfonso Rafael Alvarez-Paredes, Elvia García-López, Peter Stenvikel, Harvest F Gu, Abbul Rashid-Qureshi, Bengt Lindholm, Cleto Alvarez-Aguilar
BACKGROUND: Chronic kidney disease (CKD) is a leading complication of type 2 diabetes mellitus (T2DM) and is considered as a public health problem. Copeptin is a surrogate marker of arginine vasopressin (AVP) system and is proposed as a biomarker of decline renal function. OBJECTIVE: Evaluate whether plasma copeptin levels may be used as a biomarker of decline renal function in patients with T2DM. RESEARCH DESIGN AND METHODS: A total of 480 patients with T2DM and different stages of CKD were included...
April 14, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29651604/patterns-and-frequency-of-renal-abnormalities-in-fanconi-anaemia-implications-for-long-term-management
#3
Vijaya Sathyanarayana, Beth Lee, Neville B Wright, Rui Santos, Denise Bonney, Robert Wynn, Leena Patel, Kate Chandler, Ed Cheesman, Detlev Schindler, Nicholas J A Webb, Stefan Meyer
BACKGROUND: Fanconi anaemia (FA) is an inherited disease with bone marrow failure, variable congenital and developmental abnormalities, and cancer predisposition. With improved survival, non-haematological manifestations of FA become increasingly important for long-term management. While renal abnormalities are recognized, detailed data on patterns and frequency and implications for long-term management are sparse. METHODS: We reviewed clinical course and imaging findings of FA patients with respect to renal complications in our centre over a 25-year period to formulate some practical suggestions for guidelines for management of renal problems associated with FA...
April 12, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29650676/sodium-bicarbonate-loading-limits-tubular-cast-formation-independent-of-glomerular-injury-and-proteinuria-in-dahl-salt-sensitive-rats
#4
S C Ray, B Patel, D L Irsik, J Sun, H Ocasio, G R Crislip, C H Jin, J K Chen, B Baban, A J Polichnowski, P M O'Connor
Sodium bicarbonate (NaHCO3 ) slows the decline in kidney function in patients with chronic kidney disease (CKD), yet the mechanisms mediating this effect remain unclear. The Dahl salt-sensitive (SS) rat develops hypertension and progressive renal injury when fed a high salt diet; however, the effect of alkali loading on kidney injury has never been investigated in this model. We hypothesized that 'NaHCO3 protects from the development of renal injury in Dahl salt-sensitive rats via luminal alkalization which limits the formation of tubular casts, which are a prominent pathological feature in this model...
April 12, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29644066/patterns-of-progression-of-chronic-kidney-disease-at-later-stages
#5
Fernando Caravaca-Fontán, Lilia Azevedo, Enrique Luna, Francisco Caravaca
Background: At later stages of chronic kidney disease (CKD), a pattern of linear and irreversible renal function decline is thought to be the most common. The objective of this study was to describe the characteristics of the different patterns of CKD progression, and to investigate potentially modifiable factors associated with the rate of decline of renal function. Methods: This was a retrospective, observational study in a cohort of adult patients with CKD Stage 4 or 5 not on dialysis...
April 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29643059/higher-collagen-vi-formation-is-associated-with-all-cause-mortality-in-patients-with-type-2-diabetes-and-microalbuminuria
#6
Daniel G K Rasmussen, Tine W Hansen, Bernt J von Scholten, Signe H Nielsen, Henrik Reinhard, Hans-Henrik Parving, Martin Tepel, Morten A Karsdal, Peter K Jacobsen, Federica Genovese, Peter Rossing
OBJECTIVE: Type 2 diabetes is a common risk factor for the development of chronic kidney disease (CKD). Enhanced de novo collagen type VI (COL VI) formation has been associated with renal fibrosis and CKD. We investigated the hypothesis that PRO-C6, a product specifically generated during COL VI formation, is prognostic for adverse outcomes in patients with type 2 diabetes and microalbuminuria. RESEARCH DESIGN AND METHODS: In a prospective, observational study, we measured PRO-C6 in serum ( S -PRO-C6) and urine (U-PRO-C6) of 198 patients with type 2 diabetes and microalbuminuria without symptoms of coronary artery disease...
April 11, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29615792/exercise-in-patients-with-hypertension-and-chronic-kidney-disease-a-randomized-controlled-trial
#7
Franklin C Barcellos, Fabricio Boscolo Del Vecchio, Annelise Reges, Gregore Mielke, Iná S Santos, Daniel Umpierre, Maristela Bohlke, Pedro C Hallal
Hypertension and chronic kidney disease (CKD) are global public health problems, both associated with higher risk of cardiovascular (CV) and renal events. This trial randomized non-diabetic adult patients with hypertension and CKD stages 2-4 to 16 weeks of aerobic and resistance training or usual care. The primary outcome was the change in estimated glomerular filtration rate (eGFR). Secondary outcomes included changes in systolic and diastolic blood pressure (BP), body weight, fasting blood glucose, lipid profile, high-sensitivity C-reactive protein (hs-CRP), and functional capacity...
April 4, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29611320/high-fibroblast-growth-factor-23-concentrations-in-experimental-renal-failure-impair-calcium-handling-in-cardiomyocytes
#8
Melissa Verkaik, Maarten Oranje, Desiree Abdurrachim, Max Goebel, Zeineb Gam, Jeanine J Prompers, Michiel Helmes, Pieter M Ter Wee, Jolanda van der Velden, Diederik W Kuster, Marc G Vervloet, Etto C Eringa
The overwhelming majority of patients with chronic kidney disease (CKD) die prematurely before reaching end-stage renal disease, mainly due to cardiovascular causes, of which heart failure is the predominant clinical presentation. We hypothesized that CKD-induced increases of plasma FGF23 impair cardiac diastolic and systolic function. To test this, mice were subjected to 5/6 nephrectomy (5/6Nx) or were injected with FGF23 for seven consecutive days. Six weeks after surgery, plasma FGF23 was higher in 5/6Nx mice compared to sham mice (720 ± 31 vs...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29609642/a-comprehensive-characterization-of-myocardial-and-vascular-phenotype-in-pediatric-chronic-kidney-disease-using-cardiovascular-magnetic-resonance-imaging
#9
Mun Hong Cheang, Nathaniel J Barber, Abbas Khushnood, Jakob A Hauser, Gregorz T Kowalik, Jennifer A Steeden, Michael A Quail, Kjell Tullus, Daljit Hothi, Vivek Muthurangu
BACKGROUND: Children with chronic kidney disease (CKD) have increased cardiovascular mortality. Identifying high-risk children who may benefit from further therapeutic intervention is difficult as cardiovascular abnormalities are subtle. Although transthoracic echocardiography may be used to detect sub-clinical abnormalities, it has well-known problems with reproducibility that limit its ability to accurately detect these changes. Cardiovascular magnetic resonance (CMR) is the reference standard method for assessing blood flow, cardiac structure and function...
March 29, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29601413/masked-hypertension-and-kidney-function-decline-the-jackson-heart-study
#10
Stanford Mwasongwe, Yuan-I Min, John N Booth, Ronit Katz, Mario Sims, Adolfo Correa, Bessie Young, Paul Muntner
BACKGROUND: Hypertension diagnosed by blood pressure (BP) measured in the clinic is associated with rapid kidney function decline (RKFD) and incident chronic kidney disease (CKD). The extent to which hypertension defined using out-of-clinic BP measurements is associated with these outcomes is unclear. METHODS: We evaluated the association of any masked hypertension (daytime SBP/DBP ≥ 135/85 mmHg, night-time SBP/DBP ≥ 120/70 mmHg or 24-h SBP/DBP ≥ 130/80 mmHg) with RKFD and incident CKD among 676 African-Americans in the Jackson Heart Study with clinic-measured SBP/DBP less than 140/90 mmHg who completed ambulatory BP monitoring in 2000-2004...
March 29, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29593020/ethnic-differences-in-the-progression-of-chronic-kidney-disease-and-risk-of-death-in-a-uk-diabetic-population-an-observational-cohort-study
#11
Rohini Mathur, Gavin Dreyer, Magdi M Yaqoob, Sally A Hull
OBJECTIVE: To determine ethnic differences in the progression of chronic kidney disease (CKD) and risk of end-stage renal failure (ESRF) and death in adults with type 2 diabetes mellitus (T2DM), and to identify predictors of rapid renal decline. DESIGN: Observational community-based cohort study undertaken from 2006 to 2016 with nested case-control study. SETTING: 135 inner London primary care practices contributing to the east London Database...
March 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29589837/blood-pressure-management-and-progression-of-chronic-kidney-disease-in-a-canine-remnant-kidney-model
#12
Jun G Kang, Mi-Yeon Yu, Hajeong Lee, Dong K Kim, Kwon W Joo, Yon S Kim, Seung H Yang
The canine remnant kidney model is fundamental to understanding the relationship between hypertension and chronic kidney disease (CKD). This study aimed to create a 1/16 remnant kidney model and to determine whether blood pressure (BP) control affects the progression of CKD. A group of dogs received BP treatment (group A) and another received BP treatment except for the first 2 weeks (group B). The remnant kidney model was induced using a two-step subtotal nephrectomy method; dogs received antihypertensive therapy...
March 28, 2018: General Physiology and Biophysics
https://www.readbyqxmd.com/read/29582963/-day-of-prevention-of-renal-diseases-in-amatrice-italy
#13
Silvia Lai, Walter Valentini, Luca Poli, Lucia Broccoli, Sandro Mazzaferro, Massimiliano Crudo, Nicla Frassetti, Francesca Santoboni, Ylenia Esposito, Marco Mangiulli, Viola D'Ambrosio, Anna Chiara Currado, Adolfo Perrotta, Gaspare Elios Russo
Chronic kidney disease (CKD) is a very common condition and its prevalence is increasing worldwide. The CARHES study in Italy showed a prevalence of 6.5% in women and 7.5% in men. As a matter of fact, an early diagnosis is essential to slow down the progression and improve the renal and cardiovascular prognosis. For this purpose the A.N.Di.P. association (National Association of Peritoneal Dialysis-Onlus "Enzo Siciliano ") organized the DAY OF PREVENTION OF RENAL DISEASES which was held in AMATRICE the 15th of July 2017 called "WE START A NEW PATH OF LIFE TOGETHER"...
March 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29581872/type-2-diabetes-mellitus-related-changes-in-left-ventricular-structure-and-function-in-patients-with-chronic-kidney-disease
#14
Pei-Yu Wu, Jiun-Chi Huang, Szu-Chia Chen, Ling-I Chen
Type 2 Diabetes mellitus (DM) is the leading cause of chronic kidney disease (CKD) worldwide, and is associated with an increased risk of left ventricular (LV) hypertrophy, LV systolic and diastolic dysfunctions. The aim of this study was to investigate abnormal echocardiographic findings in patients with CKD with and without DM, and identify the factors associated with these abnormalities. We enrolled 356 pre-dialysis patients with CKD (stages 3-5), including 208 with DM and 148 without DM. The structure and systolic and diastolic functions of the left ventricle were assessed using echocardiography, and the clinical and echocardiographic parameters were analyzed...
March 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29580660/ckd-self-management-phenotypes-and-associations-with-clinical-outcomes
#15
Sarah J Schrauben, Jesse Y Hsu, Sylvia E Rosas, Bernard G Jaar, Xiaoming Zhang, Rajat Deo, Georges Saab, Jing Chen, Swati Lederer, Radhika Kanthety, L Lee Hamm, Ana C Ricardo, James P Lash, Harold I Feldman, Amanda H Anderson
BACKGROUND: To slow chronic kidney disease (CKD) progression and its complications, patients need to engage in self-management behaviors. The objective of this study was to classify CKD self-management behaviors into phenotypes and assess the association of these phenotypes with clinical outcomes. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: Adults with mild to moderate CKD enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study...
March 24, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29580580/treatment-of-diabetic-kidney-disease-with-hypertension-control-and-renin-angiotensin-system-inhibition
#16
REVIEW
Vikram Patney, Kunal Chaudhary, Adam Whaley-Connell
The global incidence and prevalence of diabetes continues to expand due primarily to the influences of obesity and the contribution of obesity to the progression of type 2 diabetes mellitus. The rising prevalence of type 2 diabetes has driven an increase in rates of CKD in the past 3 decades in the United States. In turn, so have the rates for complications related to type 2 diabetes including CKD, eg, diabetic kidney disease (DKD). Although incident rates for DKD have stabilized in the recent years, diabetes continues to be the leading cause of ESRD in the United States...
March 2018: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29579818/single-center-long-term-follow-up-of-kidney-donors-in-argentina-hospital-italiano-de-buenos-aires
#17
C A Mombelli, M C Giordani, N C Imperiali, S R Groppa, S K Villamil Cortez, C M Schreck, G J Rosa-Diez
INTRODUCTION: Living kidney donor (LKD) transplantation is increasing due to organ shortage. Clinical studies have shown that the risk of developing end-stage renal disease (ESRD) in donors is similar to that in the general population. Our goal was to evaluate postdonation renal outcomes assessed by glomerular filtration rate (GFR), proteinuria, and blood pressure. METHODS: A total of 210 LKD transplants were performed at Hospital Italiano de Buenos Aires between 2000 and 2014...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29578191/unenhanced-renal-magnetic-resonance-angiography-in-patients-with-chronic-kidney-disease-suspected-renovascular-hypertension-can-it-affect-patient-management
#18
J Yamuna, Anupama Chandrasekharan, Rajeswaran Rangasami, S Ramalakshmi, Santhosh Joseph
Background & objectives: Renal artery stenosis (RAS) is an important cause of severe hypertension in patients with chronic kidney disease (CKD). It is important to detect RAS early as it can reverse hypertension and stop rapid deterioration of renal function. The potential drawbacks of various imaging modalities used to detect RAS including contrast-related adverse effects associated with diagnostic angiography have led to increasing interest in unenhanced magnetic resonance (MR) renal angiography...
November 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29574005/prevalence-and-risk-factors-associated-with-chronic-kidney-disease-in-adults-living-in-3-different-altitude-regions-in-the-tibetan-plateau
#19
Linfeng Zhang, Zengwu Wang, Yundai Chen, Xin Wang, Zuo Chen, Bin Feng, Qinglei Zhu, Jingyu Nie, Ying Dong, Shanshan Zhou, Ye Tian, Lan Shao, Manlu Zhu
BACKGROUND: Living at high altitude may have undesirable effects on the kidney. We explored the chronic kidney disease (CKD) prevalence and risk factors among the residents living at different altitude in Tibetan Plateau. METHODS: A cross-sectional study was carried out in 2014 to 2016 in Linzhi (2900 m altitude), Lhasa (3650 m) and Anduo (4700 m). Information on the cardiovascular risk factors was collected and blood and urine samples were measured. RESULTS: The data of 1707 subjects aged ≥35 y were analyzed...
June 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29572081/ldl-oxidation-serum-uric-acid-kidney-function-and-pulse-wave-velocity-data-from-the-brisighella-heart-study-cohort
#20
Arrigo F G Cicero, Masanari Kuwabara, Richard Johnson, Marilisa Bove, Federica Fogacci, Martina Rosticci, Marina Giovannini, Sergio D'Addato, Claudio Borghi
BACKGROUND: Serum uric acid (SUA) and oxidized LDL (oxLDL) may be associated with arterial aging. The aim of our study was to evaluate the relationship between SUA, oxLDL and arterial stiffness in subjects with normal renal function and in patients with mild or moderate renal impairment. METHODS: From the database of the 2012 Brisighella Heart Study, we compared age-matched adult, non-smoker subjects without cardiovascular disease and with normal renal function (n = 205), subjects with stage II chronic kidney disease (CKD) (n = 118) and subjects with stage III CKD (n = 94)...
March 17, 2018: International Journal of Cardiology
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