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https://www.readbyqxmd.com/read/28535630/-analysis-of-risk-factors-and-prognosis-for-bleeding-in-very-old-male-patients-with-stage-5-chronic-kidney-disease
#1
X Shen, Q G Ao, Q L Cheng, S Liu, J H Zhao, Q Ma, G Yang, Y Liu
Objective: To analyze the risk factors and prognosis of bleeding in very old male patients with stage 5 chronic kidney disease (CKD). Methods: The clinical data of 143 very old male patients with stage 5 CKD was retrospectively analyzed. According to the occurrence of bleeding, the patients were divided into two groups including the hemorrhage group and the non-hemorrhage group. The history of diseases, renal function, blood cell parameters and coagulation index were compared and analyzed between the two groups...
May 16, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28529721/the-impact-of-antihypertensives-on-kidney-disease
#2
REVIEW
Diego F Marquez, Gema Ruiz-Hurtado, Luis Ruilope
Arterial hypertension and chronic kidney disease (CKD) are intimately related. The control of blood pressure (BP) levels is strongly recommended in patients with CKD in order to protect the kidney against the accompanying elevation in global cardiovascular (CV) risk. Actually, the goal BP in patients with CKD involves attaining values <140/90 mmHg except if albuminuria is present. In this case, it is often recommended to attain values <130/80 mmHg, although some guidelines still recommend <140/90 mmHg...
2017: F1000Research
https://www.readbyqxmd.com/read/28521802/identification-of-chronic-kidney-disease-patient-characteristics-influencing-the-renoprotective-effects-of-febuxostat-therapy-a-retrospective-follow-up-study
#3
Akinori Yamaguchi, Makoto Harada, Yosuke Yamada, Koji Hashimoto, Yuji Kamijo
BACKGROUND: The ability of antihyperuricemic therapy to exert renoprotective effects in patients with chronic kidney disease (CKD) is controversial. In the present study, we studied patient characteristics that may mask favorable impact of antihyperuricemic therapy on the progression of CKD. METHODS: This was a single-center, retrospective, follow-up study. One-hundred and seventy-eight CKD patients with hyperuricemia who received febuxostat therapy were included in this study...
May 18, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28513510/factors-associated-with-blood-pressure-control-in-predialysis-chronic-kidney-disease-patients-short-term-experience-from-a-single-center-in-southern-nigeria
#4
E I Okaka, O E Ojeh-Oziegbe, E I Unuigbe
BACKGROUND: Hypertension is a leading cause of kidney disease worldwide, and chronic kidney disease (CKD) is a known cause of secondary hypertension. Blood pressure (BP) control is a main-stay in the management of CKD because it retards the progression of established CKD. AIM: To determine BP control and its associated factors in predialysis CKD patients in a tertiary hospital setting. METHODOLOGY: CKD patients who attended the renal outpatient clinic during the period from December 2013 to June 2014 were recruited into the study...
May 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28503768/the-contribution-of-cardio-metabolic-risk-factors-to-estimated-glomerular-filtration-rate-egfr-decline-in-indigenous-australians-with-and-without-albuminuria-the-egfr-follow-up-study
#5
Elizabeth Barr, Federica Barzi, Jaquelyne T Hughes, George Jerums, Kerin O'Dea, Alex Brown, Elif I Ekinci, Graham Rd Jones, Paul D Lawton, Ashim Sinha, Richard J MacIsaac, Alan Cass, Louise J Maple-Brown
BACKGROUND: Risk factors for estimated glomerular filtration rate (eGFR) decline beyond albuminuria are not fully understood in Indigenous Australians who have a 6-fold risk of end-stage kidney disease. We assessed associations between cardio-metabolic risk factors and eGFR decline according to baseline albuminuria status to identify potential treatment targets. METHODS: The eGFR Follow-up study is a longitudinal cohort of 520 Indigenous Australians. Linear mixed regression was used to estimate associations between baseline cardio-metabolic risk factors and annual Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFR change (ml/min/1...
May 14, 2017: Nephrology
https://www.readbyqxmd.com/read/28501388/association-between-metabolic-syndrome-and-chronic-kidney-disease-in-a-chinese-urban-population
#6
Juan Chen, Xianglei Kong, Xiaoyan Jia, Wenbin Li, Zunsong Wang, Meiyu Cui, Dongmei Xu
BACKGROUND: Few studies have examined the relationships between the prevalence of chronic kidney disease (CKD) and the metabolic risk factors in a developing country such as China, where genetic and environmental backgrounds differ from those in Western countries. METHODS: The subjects of this cross-sectional study were the individuals from 18 to 92y. The metabolic syndrome (MetS) was defined based on the criteria of Adult Treatment Panel Third Report (ATP III), but using body mass index (BMI) instead of waist circumference...
May 10, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28499044/determinants-of-decline-of-renal-function-in-treated-hypertensive-patients-the-campania-salute-network
#7
Costantino Mancusi, Raffaele Izzo, Giovanni de Simone, Maria Viviana Carlino, Grazia Canciello, Eugenio Stabile, Nicola de Luca, Bruno Trimarco, Maria Angela Losi
Background.: Hypertension is a leading cause of chronic kidney disease (CKD) and a decrease in glomerular filtration rate (GFR) is associated with a higher prevalence of hypertension and an increased proportion of suboptimal blood pressure (BP) control. Methods.: To investigate characteristics associated with GFR decline, we selected 4539 hypertensive patients from the Campania Salute Network (mean age 53 ± 11 years) with at least 3 years of follow-up (FU) and no more than Stage III CKD...
May 12, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28496353/early-manifestations-of-renal-disease-in-patients-with-tuberous-sclerosis-complex
#8
Laura Malaga-Dieguez, Robert Spencer, Laura J Pehrson, Suzanne Vento, Kimberly Menzer, Orrin Devinsky, Howard Trachtman
OBJECTIVES: Renal manifestations are the second most significant cause of morbidity and mortality in patients with tuberous sclerosis complex (TSC), and include renal cysts, angiomyolipomas, fat-poor lesions, and malignant tumors. These lesions begin in childhood and often lead to chronic kidney disease (CKD). Little is known on the incidence of early modifiable risk factors of CKD, such as proteinuria and hypertension, or subtle decreases in glomerular filtration rate that correspond to the early stages of CKD in children with TSC...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28495909/pulse-wave-velocity-is-associated-with-cognitive-impairment-in-hemodialysis-patients
#9
Susanne Angermann, Marcus Baumann, Siegfried Wassertheurer, Christopher Clemens Mayer, Dominik Steubl, Christine Hauser, Yana Suttmann, Anna-Lena Reichelt, Robin Satanovskij, Georg Lorenz, Moritz Lukas, Bernhard Haller, Uwe Heemann, Timo Grimmer, Christoph Schmaderer
BACKGROUND: Cognitive impairment in hemodialysis patients is common and associated with adverse outcomes. So far, the underlying pathogenesis remains unclear. Therefore, we examined the potential relationship between cognitive impairment and three different categories of risk factors with particular focus on arterial stiffness measured by Pulse Wave Velocity (PWV). METHODS: A total of 201 chronic hemodialysis patients underwent cognitive testing under standardized conditions using the Montreal Cognitive Assessment (MoCA)...
May 11, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28492206/community-screening-for-pre-hypertension-traditional-risk-factors-and-markers-of-chronic-kidney-disease-in-ondo-state-south-western-nigeria
#10
Akinwumi A Akinbodewa, Ademola O Adejumo, Olusesan V Koledoye, Janet O Kolawole, Damilola Akinfaderin, Abiola O Lamidi, Gloria O Gbakinro, Christianah Ogunduyile, Walter B Osungbemiro
BACKGROUND: Chronic kidney disease (CKD) has become an epidemic with many recognised risk factors. However, the role of pre-hypertension in CKD is yet to be fully studied in our environment. OBJECTIVES: We set out to determine the magnitude of pre-hypertension and traditional CKD risk factors. We also determined their relationships to proteinuria. SUBJECTS AND METHODS: This was a descriptive, cross-sectional study conducted in two urban local government areas (Akure South and Ondo West) in Ondo State, Southwest Nigeria in March 2014...
January 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28490898/education-and-screening-for-chronic-kidney-disease-in-indian-youth-pilot-program-results
#11
Panduranga S Rao, Julie A Wright Nunes, Brenda W Gillespie, Rachel L Perlman, Rajan Ravichandran
BACKGROUND: There is a paucity of information on kidney education and screening programs in Indian youth. METHODS: Participants (n=2,158) from Chennai colleges were educated about the kidneys and chronic kidney disease (CKD) and screened in a pilot program from April to May 2013. This entailed: 1) a presentation and educational video and 2) an on-site assessment of weight, blood pressure, and demographic information. Urinalysis (UA) kits were distributed and returned in ≤48 hours...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28480805/a-review-of-chemical-therapies-for-treating-diabetic-hypertension
#12
Pantelis A Sarafidis, Maria Eleni Alexandrou, Luis M Ruilope
Hypertension and diabetes are two of the most important modifiable risk factors for cardiovascular and renal disease. The majority of patients with diabetes also have high blood pressure (BP) and the presence of hypertension in these patients dramatically increases cardiovascular and renal risk. Areas covered: This article will discuss chemical therapies for hypertension in patients with diabetes, based on currently available evidence on the effects of antihypertensive treatment on metabolic profile and renal endpoints that are the factors mostly influencing drug choice...
May 16, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28480628/prognostic-value-of-nighttime-blood-pressure-load-in-chinese-patients-with-nondialysis-chronic-kidney-disease
#13
Yan Li, Qiongxia Deng, Huiqun Li, Xinxin Ma, Jun Zhang, Hui Peng, Cheng Wang, Tanqi Lou
The prognostic value of nighttime blood pressure (BP) load in patients with chronic kidney disease (CKD) remains unknown. The prognostic value of nighttime BP load in a cohort of Chinese patients with nondialysis CKD was investigated. The authors monitored ambulatory BP and followed health outcomes in 588 Chinese CKD patients. Multivariable-adjusted Cox regression analyses indicated that nighttime BP load was a significant risk factor for all clinical outcomes in CKD patients, even when adjusted for clinic BP...
May 7, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28475386/achieving-blood-pressure-targets-for-prolonged-cardiovascular-health-a-historical-perspective
#14
Steven G Chrysant
Hypertension is a major risk factor for coronary artery disease (CAD), stroke, heart failure, and chronic kidney disease (CKD), and its successful control leads to a decrease or prevention of these complications. Areas covered: Over the years the Joint National Committees and the American Heart Association have issued guidelines regarding the treatment of hypertension. Those of 2003 and 2007 respectively, have recommended reduction of blood pressure (BP) to < 140/90 mmHg for uncomplicated hypertension and to < 130/80 mmHg for hypertensive patients with diabetes mellitus, CKD, or CAD...
May 5, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28471955/serum-vegf-c-levels-as-a-candidate-biomarker-of-hypervolemia-in-chronic-kidney-disease
#15
Tuncay Sahutoglu, Tamer Sakaci, Nuri B Hasbal, Elbis Ahbap, Ekrem Kara, Mutlu C Sumerkan, Mustafa Sevinc, Cuneyt Akgol, Yener Koc, Taner Basturk, Abdulkadir Unsal
Attaining and maintaining optimal "dry weight" is one of the principal goals during maintenance hemodialysis (MHD). Recent studies have shown a close relationship between Na load and serum vascular endothelial growth factor-C (VEGF-C) levels; thus, we aimed to investigate the role of VEGF-C as a candidate biomarker of hypervolemia. Physical examination, basic laboratory tests, N-terminal pro b-type natriuretic peptide (NT-ProBNP), echocardiography, and bioimpedance spectroscopy data of 3 groups of study subjects (euvolemic MHD patients, healthy controls, and hypervolemic chronic kidney disease [CKD] patients) were analyzed...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28469119/blood-pressure-variation-and-its-correlates-among-patients-undergoing-hemodialysis-for-renal-failure-in-benin-city-nigeria
#16
Enajite I Okaka, Chimezie G Okwuonu
BACKGROUND: Blood pressure (BP) variation is commonly encountered during hemodialysis (HD) procedure. Both intradialysis hypotension and hypertension have implications for outcome of treatment and overall morbidity and mortality of the patients. METHODOLOGY: A retrospective study was carried out in the dialysis unit of a tertiary health institution in Benin City among patients who had HD for acute kidney injury (AKI) or chronic kidney disease (CKD) over a 3-year period...
April 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/28467510/prevalence-and-determinants-of-chronic-kidney-disease-in-northeast-of-iran-results-of-the-golestan-cohort-study
#17
Sadaf G Sepanlou, Hamid Barahimi, Iraj Najafi, Farin Kamangar, Hossein Poustchi, Ramin Shakeri, Monir Sadat Hakemi, Akram Pourshams, Masoud Khoshnia, Abdolsamad Gharravi, Behrooz Broumand, Ali Nobakht-Haghighi, Kamyar Kalantar-Zadeh, Reza Malekzadeh
BACKGROUND: The burden of chronic kidney disease (CKD) is increasing globally in particular in fast emerging economies such as Iran. Population-based studies on prevalence of CKD in Iran are scarce. The objective of the current study was to explore the prevalence and determinants of CKD in the setting of Golestan Cohort Study (GCS), the largest prospective cohort in the Middle East. METHODS: In this observational study, 11,409 participants enrolled in the second phase of GCS were included...
2017: PloS One
https://www.readbyqxmd.com/read/28455660/radial-artery-sclerostin-expression-in-chronic-kidney-disease-stage-5-predialysis-patients-a-cross-sectional-observational-study
#18
Hua Zhou, Min Yang, Min Li, Li Cui
PURPOSE: Bone metabolism disorder is often associated with cardiovascular calcification in patients with chronic kidney disease (CKD). Sclerostin, a novel candidate protein, has been identified to be involved in the bone-vascular axis. The aims of the current investigation were to assess vessel sclerostin expression and its relationship with circulating sclerostin levels. METHODS: A cross-sectional observational study was conducted from January 2012 to December 2014...
April 28, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28453510/is-aspirin-associated-with-diabetic-retinopathy-the-singapore-epidemiology-of-eye-disease-seed-study
#19
Yuan Shi, Yih-Chung Tham, Ning Cheung, Jacqueline Chua, Gavin Tan, Paul Mitchell, Jie Jin Wang, Yin Bun Cheung, Ching-Yu Cheng, Tien Yin Wong
BACKGROUND/AIMS: To determine the association between aspirin use and diabetic retinopathy (DR) among persons with diabetes, in a population-based, cross-sectional study. METHODS: Subjects with diabetes aged >40 years from the Singapore Epidemiology of Eye Diseases Study were enrolled in this study. Retinal photographs were graded for DR according to the modified Airlie House classification system. Vision threatening diabetic retinopathy (VTDR) was defined as the presence of severe non-proliferative DR, or proliferative DR, or clinically significant macular oedema...
2017: PloS One
https://www.readbyqxmd.com/read/28451896/prospective-analysis-of-long-term-renal-function-in-survivors-of-childhood-wilms-tumor
#20
Marie A Neu, Alexandra Russo, Arthur Wingerter, Francesca Alt, Johanna Theruvath, Khalifa El Malki, Bettina Kron, Matthias Dittrich, Johannes Lotz, Raimund Stein, Rolf Beetz, Joerg Faber
BACKGROUND: Considering the improved outcome, a better understanding of the late effects in Wilms tumor survivors (WT-S) is needed. This study was aimed at evaluating renal function and determining the prevalence of clinical and subclinical renal dysfunction in a cohort of WT-S using a multimodal diagnostic approach. METHODS: Thirty-seven WT-S were included in this prospective cross-sectional single center study. To evaluate renal function, glomerular filtration rate (GFR) and urinary protein excretion were assessed...
April 28, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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