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https://www.readbyqxmd.com/read/28226818/stochastic-modeling-of-spontaneous-bursting-activity-to-simulate-neural-responses-of-in-vitro-networks-on-multielectrode-arrays
#1
Gaetano Valenza, Gianluca Vannucci, Enzo Wanke, Enzo Pasquale Scilingo, Gaetano Valenza, Gianluca Vannucci, Enzo Wanke, Enzo Pasquale Scilingo, Gaetano Valenza, Enzo Wanke, Gianluca Vannucci, Enzo Pasquale Scilingo
The study of neuronal bursting activity, observed in cell-culture, is physiologically important because is correlated with synaptic transmission, plasticity, and information processing. However, besides strong ethical issues related to the use of animal models, there are many limitations due to experimental setup and neural signaling acquisition. In this study, we propose a stochastic modeling approach to simulate neural dynamics observed in networks of neocortical neurons from an ex vivo normal mouse. Specifically, we devised a stochastic version of the Izhichevich's model of cortical neurons, and simulated a network of excitatory and inhibitory neurons also accounting for cell signaling delays...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226465/in-silico-pre-clinical-trials-for-implantable-cardioverter-defibrillators
#2
Zhihao Jiang, Houssam Abbas, Kuk Jin Jang, Marco Beccani, Jackson Liang, Sanjay Dixit, Rahul Mangharam, Zhihao Jiang, Houssam Abbas, Kuk Jin Jang, Marco Beccani, Jackson Liang, Sanjay Dixit, Rahul Mangharam, Jackson Liang, Marco Beccani, Sanjay Dixit, Rahul Mangharam, Houssam Abbas, Zhihao Jiang, Kuk Jin Jang
Regulatory authorities require that the safety and efficacy of a new high-risk medical device be proven in a Clinical Trial (CT), in which the effects of the device on a group of patients are compared to the effects of the current standard of care. Phase III trials can run for several years, cost millions of dollars, and expose patients to an unproven device. In this paper, we demonstrate how to use a large group of synthetic patients based on computer modeling to improve the planning of a CT so as to increase the chances of a successful trial for implantable cardioverter defibrillators (ICDs)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226052/factors-associated-with-occupational-exposure-to-biological-material-among-nursing-professionals
#3
Nádia Bruna da Silva Negrinho, Silmara Elaine Malaguti-Toffano, Renata Karina Reis, Fernanda Maria Vieira Pereira, Elucir Gir
Objective: to identify factors associated with occupational exposure to biological material among nursing professionals. Method: a cross-sectional study was conducted in a high complexity hospital of a city in the state of São Paulo, Brazil. Nursing professionals were interviewed from March to November 2015. All ethical aspects were observed. Result: among the 226 professionals interviewed, 17.3% suffered occupational exposure to potentially contaminated biological material, with 61...
January 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28226049/predictors-for-the-functional-incapacity-of-the-elderly-in-primary-health-care
#4
Lívia Carvalho Pereira, Maria do Livramento Fortes Figueiredo, Cinara Maria Feitosa Beleza, Elaine Maria Leite Rangel Andrade, Maria Josefina da Silva, Antonio Francisco Machado Pereira
Objectives: to assess the predictors for the functional incapacity of the elderly in primary health care. Method: cross-sectional study, of which 388 older people participated, conducted in three Primary health care Units, using the Katz index and Lawton's scale. The research project was approved by the Research Ethics Committee. Results: regarding the degree of dependency for Basic Activities, 90.2% were less independent for dressing themselves; and for Instrumental Activities, 77...
January 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28225996/effect-of-diacerein-as-an-add-on-to-metformin-in-patients-with-type-2-diabetes-mellitus-and-inadequate-glycemic-control
#5
Miriam Méndez-Del Villar, Esperanza Martínez-Abundis, Rafael O Preciado-Márquez, Manuel González-Ortiz
Objective: To evaluate the effect of diacerein as an add-on to metformin in patients with type 2 diabetes mellitus (T2DM) and inadequate glycemic control. Materials and methods: A randomized, double-blind, placebo-controlled clinical trial was carried out on 12 patients with T2DM and inadequate glycemic control [glycated hemoglobin A1c (A1C) ≥ 7%] with metformin as monotherapy (≥ 1500 mg per day) for at least the previous 90 days. Fasting and postprandial glucose were measured before and after the pharmacological intervention...
February 13, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28225854/analysis-of-risk-prediction-capability-and-validity-of-morse-fall-scale-brazilian-version
#6
Janete de Souza Urbanetto, Thiana Sebben Pasa, Hélio Radke Bittencout, Flavia Franz, Vitor Pena Prazido Rosa, Tânia Solange Bosi de Souza Magnago
Objective: To analyse the power to predict risk and verify the validity of the Morse Fall Scale - Brazilian version (MFS-B). Method: This is a methodological, longitudinal study with 1487 adult patients of two university hospitals of Rio Grande do Sul, Brazil conducted from November 2013 to March 2014. The MFS-B was used to assess the risk of falls. Statistical analysis comprised multivariate methods (discriminant function analysis and ROC curve). The research was approved by the ethics committees of the institutions...
February 16, 2017: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/28225815/different-characteristics-of-mesenchymal-stem-cells-isolated-from-different-layers-of-full-term-placenta
#7
Yoo Shin Choi, Yong-Beom Park, Chul-Won Ha, Jin A Kim, Jin-Chul Heo, Woo-Jung Han, Soo-Young Oh, Suk-Joo Choi
BACKGROUND: The placenta is a very attractive source of mesenchymal stem cells (MSCs) for regenerative medicine due to readily availability, non-invasive acquisition, and avoidance of ethical issues. Isolating MSCs from parts of placenta tissue has obtained growing interest because they are assumed to exhibit different proliferation and differentiation potentials due to complex structures and functions of the placenta. The objective of this study was to isolate MSCs from different parts of the placenta and compare their characteristics...
2017: PloS One
https://www.readbyqxmd.com/read/28225714/regarding-%C3%A3-zcakar-l-%C3%A3-nat-ss-g%C3%A3-rcay-e-kara-m-are-blind-injections-ethical-or-historical-think-twice-with-ultrasound-am-j-phys-med-rehabil-2016-95-158-60
#8
Myron M LaBan, Susan K Weir
No abstract text is available yet for this article.
March 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28225701/the-case-of-dr-oz-ethics-evidence-and-does-professional-self-regulation-work
#9
Jon C Tilburt, Megan Allyse, Frederic W Hafferty
Dr. Mehmet Oz is widely known not just as a successful media personality donning the title "America's Doctor(®)," but, we suggest, also as a physician visibly out of step with his profession. A recent, unsuccessful attempt to censure Dr. Oz raises the issue of whether the medical profession can effectively self-regulate at all. It also raises concern that the medical profession's self-regulation might be selectively activated, perhaps only when the subject of professional censure has achieved a level of public visibility...
February 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28225700/seeking-legitimacy-for-dsm-5-the-bereavement-exception-as-an-example-of-failed-process
#10
James E Sabin, Norman Daniels
In 2013 the American Psychiatric Association (APA) published the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Even before publication, DSM-5 received a torrent of criticism, most prominently over removal of the "bereavement exclusion" for the diagnosis of major depression. We argue that while the APA can claim legitimate authority for deciding scientific questions, it does not have legitimacy for resolving what is ultimately a question of ethics and public policy. We show how the "accountability for reasonableness" framework for seeking legitimacy in health policy could have been used to achieve a better resolution of the conflict than actually occurred...
February 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28225699/what-is-the-relevance-of-procedural-fairness-to-making-determinations-about-medical-evidence
#11
Govind Persad
Approaches relying on fair procedures rather than substantive principles have been proposed for answering dilemmas in medical ethics and health policy. These dilemmas generally involve two questions: the epistemological (factual) question of which benefits an intervention will have, and the ethical (value) question of how to distribute those benefits. This article focuses on the potential of fair procedures to help address epistemological and factual questions in medicine, using the debate over antidepressant efficacy as a test case...
February 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28225694/polarities-in-clinical-thinking-and-practice
#12
John Z Sadler
This analysis of a case of a bereaved patient that poses two treatment options-watchful waiting or medication-focuses on five "polarities" in clinical practice: (1) the normal and the pathological, (2) the individual and the diagnostic collective, (3) the primary care physician and the consultant, (4) the expert and nonexpert, and (5) the moment and the process. These polarities can accentuate ethical problems posed by this case, for example, by creating stark contrasts that mask the complex contexts of care and characteristics of patients...
February 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28225664/historic-leadership
#13
Ellen F Johnsen, Katherine J Pohlman
School nursing practice establishes itself in the midst of both education and nursing philosophies, ethics, standards, laws, and regulations. Treading these two worlds is difficult at times and requires that a school nurse possess a strong foundational knowledge base, seek professional collaboration, and navigate conflicting professional demands in order to promote student and public safety. This article is Part 2 of a four-part series that recounts the inspiring story of a school nurse, Ellen Johnsen, who did just that back in the 1980s in Broken Arrow, Oklahoma...
March 2017: NASN School Nurse
https://www.readbyqxmd.com/read/28225649/medical-mimics-of-child-abuse
#14
Cindy W Christian, Lisa J States
OBJECTIVE: Physicians have an ethical and legal mandate to identify abused children so that they may be protected from further harm and are simultaneously required to think broadly and objectively about differential diagnoses. The medical literature is replete with examples of medical diseases that mimic abuse, potentially leading to misdiagnoses and subsequent harm to children and families. CONCLUSION: This review highlights some of the common and uncommon diseases that mimic physical and sexual abuse of children...
February 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28225506/effects-of-single-dose-preemptive-intravenous-ibuprofen-on-postoperative-opioid-consumption-and-acute-pain-after-laparoscopic-cholecystectomy
#15
Elif Oral Ahiskalioglu, Ali Ahiskalioglu, Pelin Aydin, Ahmet Murat Yayik, Ayetullah Temiz
BACKGROUND: Although studies involving intravenous (IV) ibuprofen are still limited, it has been shown to have a potential role in the treatment of postoperative pain. The primary objective of this study was to investigate the effects of preemptive IV ibuprofen on postoperative 24 hour opioid consumption and postoperative pain in patients undergoing laparoscopic cholecystectomy. METHODS: Following ethical committee approval, 60 patients aged 18 to 65, American Society of Anesthesiology (ASA) I-II, and scheduled for laparoscopic cholecystectomy were included in this prospective, randomized, double-blinded study...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28225505/nonrevascularizable-buttock-claudication-improved-with-sildenafil-a-case-report
#16
Loukman Omarjee, Audrey Camarzana, Samir Henni, Pierre Abraham
RATIONALE: Sildenafil, a phosphodiesterase-5-inhibitor (PDE5i), could represent a new treatment in addition to the medical treatment and advice to walk in peripheral arterial disease (PAD). PATIENT CONCERNS AND DIAGNOSES: We report a case of a 62-year-old heavy smoker man who developed a buttock claudication and a severe walking limitation following an aorto-bi-femoral bypass in 1992. Since 2003, each year, he has been referred for investigation of bilateral buttock claudication on treadmill using transcutaneous oxygen pressure (tcpO2) measurement during exercise to argue for the vascular origin of the walking impairment...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28225459/it-is-time-to-cancel-medicine-s-social-contract-metaphor
#17
John M Harris
There is agreement that the complex relationship between medicine and society is best described as a metaphorical social contract and that professionalism is the medical profession's contribution to this contract. Metaphors can help clarify abstract concepts, but they can also be abused if the counterfactual attributes of a metaphor become attributed to its subject. This seems to be happening with medical professionalism, which has sometimes been reduced to a contracted deliverable and a bargaining chip. The undesirable attributes of the social contract metaphor may be hindering efforts to understand and teach medical professionalism...
February 21, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28224459/effect-of-hallucinogens-on-unconditioned-behavior
#18
Adam L Halberstadt, Mark A Geyer
Because of the ethical and regulatory hurdles associated with human studies, much of what is known about the psychopharmacology of hallucinogens has been derived from animal models. However, developing reliable animal models has proven to be a challenging task due to the complexity and variability of hallucinogen effects in humans. This chapter focuses on three animal models that are frequently used to test the effects of hallucinogens on unconditioned behavior: head twitch response (HTR), prepulse inhibition of startle (PPI), and exploratory behavior...
February 22, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28223855/perception-of-educational-value-in-clinical-rotations-by-medical-students
#19
David A Kandiah
AIM: Clinical teaching in Australian medical schools has changed to meet the needs of substantially increased medical student cohorts. As such, formal feedback from these student cohorts is needed about the value they place on the educational input from each clinical rotation. This study aims to determine which aspects of clinical placements are most educationally useful to medical students. METHODS: In this study, final year medical students from the University of Western Australia (UWA) were surveyed via an anonymous online questionnaire, identifying which clinical placements were found to be the most and the least useful to their learning and the positive aspects of these placements...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28223465/assessment-of-bohr-and-enghoff-dead-space-equations-in-mechanically-ventilated-children
#20
Pierre Bourgoin, Florent Baudin, David Brossier, Guillaume Emeriaud, Marc Wysocki, Philippe Jouvet
BACKGROUND: Recent findings suggest that using alveolar PCO2 (PACO2 ) estimated by volumetric capnography in the Bohr equation instead of PaCO2 (Enghoff modification) could be appropriate for the calculation of physiological dead space to tidal volume ratio (VD/VT Bohr and VD/VT Enghoff, respectively). We aimed to describe the relationship between these 2 measurements in mechanically ventilated children and their significance in cases of ARDS. METHODS: From June 2013 to December 2013, mechanically ventilated children with various respiratory conditions were included in this study...
February 21, 2017: Respiratory Care
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