Reward saccade

Although it has been suggested that reward expectation affects the performance of spatial working memory tasks, controversial results have been found in previous experiments. Hence, it is still unclear to what extent reward expectation has an effect on working memory. To clarify this question, a memory-guided saccade task was applied, in which participants were instructed to retain and reconstruct a temporospatial sequence of four locations by moving their eyes in each trial. The global- and local-level spatial working memory accuracies were calculated to determine the reward effect on the global and local level of processing in spatial working memory tasks...

When searching for an object, do we minimize the number of eye movements we need to make? Under most circumstances, the cost of saccadic parsimony likely outweighs the benefit, given the cost is extensive computation and the benefit is a few hundred milliseconds of time saved. Previous research has measured the proportion of eye movements directed to locations where the target would have been visible in the periphery as a way of quantifying the proportion of superfluous fixations. A surprisingly large range of individual differences has emerged from these studies, suggesting some people are highly efficient and others much less so...

Humans and other primates are equipped with a foveated visual system. As a consequence, we reorient our fovea to objects and targets in the visual field that are conspicuous or that we consider relevant or worth looking at. These reorientations are achieved by means of saccadic eye movements. Where we saccade to depends on various low-level factors such as a targets' luminance but also crucially on high-level factors like the expected reward or a targets' relevance for perception and subsequent behavior. Here, we review recent findings how the control of saccadic eye movements is influenced by higher-level cognitive processes...

When reaching for an object with the hand, the gaze is usually directed at the target. In a laboratory setting, fixation is strongly maintained at the reach target until the reaching is completed, a phenomenon known as "gaze-anchoring". While conventional accounts of such tight eye-hand coordination have often emphasized the internal synergetic linkage between both motor systems, more recent optimal control theories regard motor coordination as the adaptive solution to task requirements. We here investigated to what degree gaze control during reaching is modulated by task demands...

Food-related impulsivity, i.e. a food-related attentional bias proposed to be due to increased reward sensitivity and diminished inhibitory control, has been cross-sectionally associated with binge eating disorder. To analyze changes in food-related impulsivity, we implemented longitudinal analyses of objective laboratory tasks in a randomized controlled trial called IMPULS. Patients who attended an impulsivity-focused group intervention (IG N = 31) and control patients who did not take part in the intervention (CG N = 25) were compared before (T0) and after the intervention period (T1) and at three months follow-up (T2)...

Clinical apathy results in dysfunction of goal directed behaviour, a key component of which is the initiation of action. Previous work has suggested that blunting of reward sensitivity is an important mechanism underlying apathy. However, an additional component might be impoverished initiation of action itself. This study aims to investigate the link between motivation and motor output and its association with apathy and dopamine. An oculomotor task that measures pupillary and saccadic response to monetary incentives was used to assess reward sensitivity, first in 23 young and 18 elderly controls, and then in 22 patients with Parkinson's disease tested ON and OFF dopaminergic medication...

Contemporary theories predict that Inhibitory Control (IC) can be improved when rewards are available for successfully inhibiting. In non-clinical samples empirical research has demonstrated some support, however 'null' findings have also been published. The aim of this meta-analysis was to clarify the magnitude of the effect of reward on IC, and identify potential moderators. Seventy-three articles (contributing k = 80 studies) were identified from Pubmed, PsychInfo and Scopus, published between 1997 - 2020, using a systematic search strategy...

The basal ganglia have long been considered crucial for associative learning, but whether they also are involved in another type of learning, error-based motor learning, is not clear. Error-based learning has been considered the province of the cerebellum. However, learning to use a robotic arm and saccade adaptation, which use error-based learning, are facilitated by motivation, which is a function of the basal ganglia. Additionally, patients with Parkinson's disease, a basal ganglia deficit, show slower saccade adaptation than age matched controls...

Impairments of working memory are commonly observed in a variety of neurodegenerative disorders but they are difficult to quantitatively assess in clinical cases. Recent studies in experimental animals have used low-dose ketamine (an NMDA receptor antagonist) to disrupt working memory, partly mimicking the pathophysiology of schizophrenia. Here, we developed a novel behavioral paradigm to assess multiple components of working memory and applied it to monkeys with and without ketamine administration. In an oculomotor foraging task, the animals were presented with 15 identical objects on the screen...

How does the brain maintain spatial attention despite the retinal displacement of objects by saccades? A possible solution is to use the vector of an upcoming saccade to compensate for the shift of objects on eye-centered (retinotopic) brain maps. In support of this hypothesis, previous studies have revealed attentional effects at the future retinal locus of an attended object, just before the onset of saccades. A critical yet unresolved theoretical issue is whether predictively remapped attentional effects would persist long enough on eye-centered brain maps, so no external input (goal, expectation, reward, memory, etc...

Popular models of decision-making propose that noisy sensory evidence accumulates until reaching a bound. Behavioral evidence as well as trial-averaged ramping of neuronal activity in sensorimotor regions of the brain support this idea. However, averaging activity across trials can mask other processes, such as rapid shifts in decision commitment, calling into question the hypothesis that evidence accumulation is encoded by delay-period activity of individual neurons. We mined two sets of data from experiments in four monkeys in which we recorded from SC neurons during two different decision-making tasks and a delayed-saccade task...

Basal ganglia contribute to object-value learning, which is critical for survival. The underlying neuronal mechanism is the association of each object with its rewarding outcome. However, object values may change in different environments and we then need to choose different objects accordingly. The mechanism of this environment-based value learning is unknown. To address this question, we created an environment-based value task in which the value of each object was reversed depending on the two scene-environments (X and Y)...

Express saccades, a distinct fast mode of visually guided saccades, are probably underpinned by a specific pathway that is at least partially different from the one underlying regular saccades. Whether and how this pathway deals with information on the subjective value of a saccade target is unknown. We studied the influence of varying reward expectancies and compared it with the impact of a temporal gap between the disappearance of the fixation dot and the appearance of the target on the visually guided saccades of two rhesus macaques (Macaca mulatta)...

Many decisions require trade-offs between sensory evidence and internal preferences. Potential neural substrates include the frontal eye field (FEF) and caudate nucleus, but their distinct roles are not understood. Previously we showed that monkeys' decisions on a direction-discrimination task with asymmetric rewards reflected a biased accumulate-to-bound decision process (Fan et al., 2018) that was affected by caudate microstimulation (Doi et al., 2020). Here we compared single-neuron activity in FEF and caudate to each other and to accumulate-to-bound model predictions derived from behavior...

Working memory is essential: it serves to guide intelligent behavior of humans and nonhuman primates when task-relevant stimuli are no longer present to the senses. Moreover, complex tasks often require that multiple working memory representations can be flexibly and independently maintained, prioritized, and updated according to changing task demands. Thus far, neural network models of working memory have been unable to offer an integrative account of how such control mechanisms can be acquired in a biologically plausible manner...

We can be motivated when reward depends on performance, or merely by the prospect of a guaranteed reward. Performance-dependent (contingent) reward is instrumental, relying on an internal action-outcome model, whereas motivation by guaranteed reward may minimise opportunity cost in reward-rich environments. Competing theories propose that each type of motivation should be dependent on dopaminergic activity. We contrasted these two types of motivation with a rewarded saccade task, in patients with Parkinson's disease (PD)...

RATIONALE: Previous research has shown that physically salient and reward-related distractors can automatically capture attention and eye gaze in a visual search task, even though participants are motivated to ignore these stimuli. OBJECTIVES: To examine whether an acute, low dose of alcohol would influence involuntary attentional capture by stimuli signalling reward. METHODS: Participants were assigned to the alcohol or placebo group before completing a visual search task...

Humans scan their visual environment using saccade eye movements. Where we look is influenced by bottom-up salience and top-down factors, like value. For reactive saccades in response to suddenly appearing stimuli, it has been shown that short-latency saccades are biased towards salience, and that top-down control increases with increasing latency. Here, we show, in a series of six experiments, that this transition towards top-down control is not determined by the time it takes to integrate value information into the saccade plan, but by the time it takes to inhibit suddenly appearing salient stimuli...

In the search for the function of mirror neurons, a previous study reported that F5 mirror neuron responses are modulated by the value that the observing monkey associates with the grasped object. Yet we do not know whether mirror neurons are modulated by the expected reward value for the observer or also by other variables, which are causally dependent on value (e.g. motivation, attention directed at the observed action, arousal). In order to clarify this, we trained two rhesus macaques to observe a grasping action on an object kept constant, followed by 4 fully predictable outcomes of different values (two outcomes with positive and two with negative emotional valence)...

Impulse control disorders in Parkinson's disease are common neuropsychiatric complications associated with dopamine replacement therapy. Some patients treated with dopamine agonists develop pathological behaviours, such as gambling, compulsive eating, shopping, or disinhibited sexual behaviours, which can have a severe impact on their lives and that of their families. In this study we investigated whether hypersensitivity to reward might contribute to these pathological behaviours and how this is influenced by dopaminergic medication...