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https://www.readbyqxmd.com/read/28749570/hepatocyte-derived-exosomes-promote-t-follicular-regulatory-cell-expansion-during-hcv-infection
#1
Dustin A Cobb, Lucy Golden-Mason, Hugo R Rosen, Young S Hahn
Hepatitis C virus (HCV) is a global health concern that can cause severe liver disease such as cirrhosis and hepatocellular carcinoma. Control of HCV requires vigorous T cell responses, yet CD4(+) T cells in chronic HCV patients are dysfunctional. T follicular regulatory (Tfr) cells are a subset of regulatory T cells that suppress T follicular helper (Tfh) cells and the generation of high affinity antibody-producing B cells. In this study, we examined the accumulation of Tfr cells in the liver compartment during chronic HCV infection and defined the cellular and molecular mechanisms underlying their expansion...
July 27, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28749561/trends-in-prevalence-of-leisure-time-physical-activity-and-inactivity-results-from-australian-national-health-surveys-1989-to-2011
#2
Josephine Chau, Tien Chey, Sarah Burks-Young, Lina Engelen, Adrian Bauman
OBJECTIVE: To examine trends in leisure time physical activity and inactivity in Australians aged 15 years or older from 1989 to 2011. METHOD: We used data from six Australian National Health Surveys conducted from 1989/90 to 2011/12 in which physical activity was assessed using comparable questions. Analyses examined trends in the prevalence of sufficient physical activity (≥150 minutes/week moderate-to-vigorous physical activity) and of inactivity (<30 minutes/week moderate-to-vigorous physical activity)...
July 27, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28745558/ambient-particulate-matter-may-affect-lung-function-of-motorcycle-taxi-drivers-in-bangkok
#3
Sara Arphorn, Tomohiro Ishimaru, Kunio Hara, Suwisa Mahasandana
PURPOSE: The motorcycle taxi drivers of Bangkok have been heavily exposed to high concentrations of PM10 and the impact of this on their lungs has been neither documented nor studied. This study examines the association between exposure to PM10 and lung function decline among motorcycle taxi drivers. METHODS: A cross-sectional study was conducted in Bangkok between two groups: a subject group of motorcycle taxi drivers and control group of enclosed vehicle taxi drivers...
July 26, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28745208/thiazole-containing-heterocycles-with-cns-activity
#4
Priyanka Kalal, Divyani Gandhi, Prakash Prajapat, Shikha Agarwal
BACKGROUND: Thiazoles are promising scaffolds in the area of medicinal and pharmaceutical chemistry and have accounted to show different pharmacophoric properties. For the last years, thiazole derivatives have focused too much attention to develop different new CNS active agents. It has been broadly used to generate diverse therapeutic agents against various CNS targets. Histamine H3 receptors are seriously involved in the pathophysiology of numerous disorders of the central nervous system...
July 24, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/28744057/the-effects-of-treatment-room-lighting-color-on-time-perception-and-emotion
#5
Seulki Han, Daehee Lee
[Purpose] The purpose of this study was to investigate the perceived treatment times and emotional reactions under different light colors in the treatment room. [Subjects and Methods] Subjects in this study were 20 healthy young students in their 20s. Under each lighting condition (blue, red, white, and yellow) differentiated by color, each subject laid on a therapeutic bed and underwent ultrasound therapy. Subjects were instructed to press a stopwatch every 1 minute, for a total of 5 times, after therapy started according to their perception of time while the stopwatch's time indicator was blocked...
July 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28743370/computational-and-clinical-investigation-on-the-role-of-mechanical-vibration-on-orthodontic-tooth-movement
#6
Zhipeng Liao, Selma Elekdag-Turk, Tamer Turk, Johnathan Grove, Oyku Dalci, Junning Chen, Keke Zheng, M Ali Darendeliler, Michael Swain, Qing Li
The aim of this study is to investigate the biomechanics for orthodontic tooth movement (OTM) subjected to concurrent single-tooth vibration (50Hz) with conventional orthodontic force application, via a clinical study and computational simulation. Thirteen patients were recruited in the clinical study, which involved distal retraction of maxillary canines with 1.5N (150g) force for 12weeks. In a split mouth study, vibration and non-vibration sides were randomly assigned to each subject. Vibration of 50Hz, of approximately 0...
June 21, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28743184/surface-fluorination-of-reactive-battery-anode-materials-for-enhanced-stability
#7
Jie Zhao, Lei Liao, Feifei Shi, Ting Lei, Guangxu Chen, Allen Pei, Jie Sun, Kai Yan, Guangmin Zhou, Jin Xie, Chong Liu, Yuzhang Li, Zheng Liang, Zhenan Bao, Yi Cui
Significant increase in energy density of batteries must be achieved by exploring new materials and cell configurations. Lithium metal and lithiated silicon are two promising high-capacity anode materials. Unfortunately, both these anodes require reliable passivating layer to survive the serious environmental corrosion during handling and cycling. Here we developed a surface fluorination process to form a homogeneous and dense LiF coating on reactive anode materials, with in situ generated fluorine gas by using a fluoropolymer, CYTOP, as the precursor...
July 26, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28742399/nutrition-and-cancer-an-historical-perspective-the-past-present-and-future-of-nutrition-and-cancer-part-2-misunderstanding-and-ignoring-nutrition
#8
T Colin Campbell
The role that nutrition plays in cancer development and treatment has received considerable attention in recent decades, but it still engenders considerable controversy. Within the cancer research and especially the clinical community, for example, nutritional factors are considered to play, at best, a secondary role. The role of nutrition in cancer development was noted by authorities as far back as the early 1800s, generally under the theory that cancer is "constitutional" in its origin, implying a complex, multifactorial, multistage etiology...
July 25, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28741127/wing-morphology-winter-ecology-and-fecundity-selection-evidence-for-sex-dependence-in-barn-swallows-hirundo-rustica
#9
Nicola Saino, Roberto Ambrosini, Manuela Caprioli, Felix Liechti, Andrea Romano, Diego Rubolini, Chiara Scandolara
Variation in wing morphology results from the combination of diverse selection pressures. Wing feather morphology within species varies with sex and ontogenetic effects, and also with ecological factors. Yet, the direction of causation for the wing morphology-ecology association remains to be elucidated. Under the 'ecology-dependence' hypothesis, wing morphology covaries with ecological conditions, because the latter affect feather molt. Alternatively, the 'habitat choice' hypothesis posits that individuals with different wing morphology choose different habitats because of the habitat-dependent advantages of a specific wing morphology...
July 25, 2017: Oecologia
https://www.readbyqxmd.com/read/28739834/change-in-physical-activity-from-adolescence-to-early-adulthood-a-systematic-review-and-meta-analysis-of-longitudinal-cohort-studies
#10
REVIEW
Kirsten Corder, Eleanor Winpenny, Rebecca Love, Helen Elizabeth Brown, Martin White, Esther van Sluijs
OBJECTIVE: To systematically review and meta-analyse how physical activity (PA) changes from adolescence to early adulthood (13-30 years). DATA SOURCES: Seven electronic databases were searched: Medline, Embase, PsycInfo, SCOPUS, ASSIA, SPORTdiscus and Web of Science. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: English-language, longitudinal studies (from 01/1980 to 01/2017) assessing PA ≥twice, with the mean age of ≥1 measurement in adolescence (13-19 years) and ≥1 in young adulthood (16-30 years) were included...
July 24, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28738790/validity-and-reliability-of-an-adapted-arabic-version-of-the-long-international-physical-activity-questionnaire
#11
Khalil Helou, Nour El Helou, Maya Mahfouz, Yara Mahfouz, Pascale Salameh, Mireille Harmouche-Karaki
BACKGROUND: The International Physical Actvity Questionnaire (IPAQ) is a validated tool for physical activity assessment used in many countries however no Arabic version of the long-form of this questionnaire exists to this date. Hence, the aim of this study was to cross-culturally adapt and validate an Arabic version of the long International Physical Activity Questionnaire (AIPAQ) equivalent to the French version (F-IPAQ) in a Lebanese population. METHODS: The guidelines for cross-cultural adaptation provided by the World Health Organization and the International Physical Activity Questionnaire committee were followed...
July 24, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28737729/geographic-distribution-and-temporal-trends-of-hiv-1-subtypes-through-heterosexual-transmission-in-china-a-systematic-review-and-meta-analysis
#12
REVIEW
Peipei Xiao, Jianjun Li, Gengfeng Fu, Ying Zhou, Xiping Huan, Haitao Yang
Background: Heterosexual transmission (HST) has become the current predominant transmission pathways of the HIV-1 epidemic in China. The aim of this study was to explore the geographic and dynamic change of HIV-1 subtypes through HST in China from published studies. Methods: Several electronic databases were searched to identify the studies, and the overall prevalence of HIV-1 subtypes was estimated by a meta-analysis method. Subgroup analysis was conducted by study region and time period. Publication bias was evaluated using Egger's test...
July 24, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28736168/light-dependent-degradation-of-pif3-by-scf-ebf1-2-promotes-a-photomorphogenic-response-in-arabidopsis
#13
Jie Dong, Weimin Ni, Renbo Yu, Xing Wang Deng, Haodong Chen, Ning Wei
Plant seedlings emerging from darkness into the light environment undergo photomorphogenesis, which enables autotrophic growth with optimized morphology and physiology. During this transition, plants must rapidly remove photomorphogenic repressors accumulated in the dark. Among them is PHYTOCHROME-INTERACTING FACTOR 3 (PIF3), a key transcription factor promoting hypocotyl growth. Here we report that, in response to light activation of phytochrome photoreceptors, EIN3-BINDING F BOX PROTEINs (EBFs) 1 and 2 mediate PIF3 protein degradation in a manner dependent on light-induced phosphorylation of PIF3...
July 18, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28735755/protective-effects-of-acute-exercise-prior-to-doxorubicin-on-cardiac-function-of-breast-cancer-patients-a-proof-of-concept-rct
#14
A A Kirkham, R E Shave, K A Bland, J M Bovard, N D Eves, K A Gelmon, D C McKenzie, S A Virani, E J Stöhr, D E R Warburton, K L Campbell
BACKGROUND: Preclinical studies have reported that a single treadmill session performed 24h prior to doxorubicin provides cardio-protection. We aimed to characterize the acute change in cardiac function following an initial doxorubicin treatment in humans and determine whether an exercise session performed 24h prior to treatment changes this response. METHODS: Breast cancer patients were randomized to either 30min of vigorous-intensity exercise 24h prior to the first doxorubicin treatment (n=13), or no vigorous exercise for 72h prior to treatment (control, n=11)...
July 14, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28734461/risk-factors-for-mortality-among-individuals-with-peripheral-arterial-disease
#15
Stephen M Amrock, Cherrie Z Abraham, Enjae Jung, Pamela B Morris, Michael D Shapiro
Morbidity and mortality from peripheral arterial disease (PAD) continues to increase. Traditional cardiovascular risk factors are implicated in the development of PAD, yet the extent to which those risk factors correlate with mortality in such patients remains insufficiently assessed. Using data from the 1999 to 2004 National Health and Nutrition Examination Survey, Cox proportional hazards models were used to examine the association of cardiovascular risk factors and all-cause and cardiovascular mortality...
June 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28734170/web-based-physical-activity-interventions-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#16
REVIEW
Leila Jahangiry, Mahdieh Abbasalizad Farhangi, Sakineh Shab-Bidar, Fatemeh Rezaei, T Pashaei
OBJECTIVES: It was estimated that approximately 60% of the world's population is classified as inactive or insufficiently active. This meta-analysis investigated the effect of web-based interventions on different types of physical activity (PA) measurements in general population and potential moderating variables. STUDY DESIGN: PubMed, CINAHL, EBSCOhost, PsycINFO, Scopus, Ovid, and ScienceDirect literature searches were conducted to identify studies investigating the effect of web-based interventions on PA...
July 19, 2017: Public Health
https://www.readbyqxmd.com/read/28733576/mait-cells-accumulate-in-placental-intervillous-space-and-display-a-highly-cytotoxic-phenotype-upon-bacterial-stimulation
#17
Martin Solders, Laia Gorchs, Tom Erkers, Anna-Carin Lundell, Silvia Nava, Sebastian Gidlöf, Eleonor Tiblad, Isabelle Magalhaes, Helen Kaipe
During pregnancy, the maternal immune system must tolerate the developing foetus, and yet retain a potent antimicrobial response to prevent infections. Mucosal associated invariant T (MAIT) cells recognize microbial-derived vitamin B metabolites presented on the MR1 molecule, but their presence and function at the foetal-maternal interface is not known. We here isolated mononuclear cells from paired samples of peripheral blood (PB), intervillous blood (IVB), and decidua parietalis (DP) following uncomplicated term pregnancies...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28733344/effects-of-exercise-on-fitness-and-health-of-adults-with-spinal-cord-injury-a-systematic-review
#18
REVIEW
Jan W van der Scheer, Kathleen A Martin Ginis, David S Ditor, Victoria L Goosey-Tolfrey, Audrey L Hicks, Christopher R West, Dalton L Wolfe
OBJECTIVE: To synthesize and appraise research testing the effects of exercise interventions on fitness, cardiometabolic health, and bone health among adults with spinal cord injury (SCI). METHODS: Electronic databases were searched (1980-2016). Included studies employed exercise interventions for a period ≥2 weeks, involved adults with acute or chronic SCI, and measured fitness (cardiorespiratory fitness, power output, or muscle strength), cardiometabolic health (body composition or cardiovascular risk factors), or bone health outcomes...
July 21, 2017: Neurology
https://www.readbyqxmd.com/read/28730841/effectiveness-of-a-worksite-intervention-for-male-construction-workers-on-dietary-and-physical-activity-behaviors-body-mass-index-and-health-outcomes-results-of-a-randomized-controlled-trial
#19
Laura Viester, Evert A L M Verhagen, Paulien M Bongers, Allard J van der Beek
PURPOSE: To evaluate the effectiveness of an individually tailored intervention for improvement in lifestyle behavior, health indicators, and prevention and reduction of overweight among construction workers. DESIGN: Randomized controlled trial. SETTING: Various blue-collar departments of a large construction company in the Netherlands. PARTICIPANTS: Blue-collar workers randomized to an intervention (n = 162) or a control group (n = 152)...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/28730506/hiatus-hernia-as-a-cause-of-dysphagia
#20
REVIEW
Hamish Philpott, Rami Sweis
PURPOSE OF REVIEW: This review aims to discuss the putative relationship between hiatus hernia and dysphagia. RECENT FINDINGS: Proposed mechanisms of dysphagia in patients with hiatus hernia are usually difficult to identify, but recent advances in technology (high-resolution manometry with or without concomitant impedance, ambulatory pH with impedance, videofluoroscopy, and the endoluminal functional lumen imaging probe (EndoFLIP)) and methodology (inclusion of swallows of various consistencies and volumes or shifting position during the manometry protocol) can help induce symptoms and identify the underlying disorder...
August 2017: Current Gastroenterology Reports
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