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Functional Hops

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https://www.readbyqxmd.com/read/28325809/the-rab7-effector-plekhm1-binds-arl8b-to-promote-cargo-traffic-to-lysosomes
#1
Rituraj Marwaha, Subhash B Arya, Divya Jagga, Harmeet Kaur, Amit Tuli, Mahak Sharma
Endocytic, autophagic, and phagocytic vesicles move on microtubule tracks to fuse with lysosomes. Small GTPases, such as Rab7 and Arl8b, recruit their downstream effectors to mediate this transport and fusion. However, the potential cross talk between these two GTPases is unclear. Here, we show that the Rab7 effector PLEKHM1 simultaneously binds Rab7 and Arl8b, bringing about clustering and fusion of late endosomes and lysosomes. We show that the N-terminal RUN domain of PLEKHM1 is necessary and sufficient for interaction with Arl8b and its subsequent localization to lysosomes...
March 21, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28321428/high-grade-partial-and-retracted-2-cm-proximal-hamstring-ruptures-nonsurgical-treatment-revisited
#2
Jonathan R Piposar, Amrit V Vinod, Joshua R Olsen, Edward Lacerte, Suzanne L Miller
BACKGROUND: High-grade partial proximal hamstring tears and complete tears with retraction less than 2 cm are a subset of proximal hamstring injuries where, historically, treatment has been nonoperative. It is unknown how nonoperative treatment compares with operative treatment. HYPOTHESIS: The clinical and functional outcomes of nonoperative and operative treatment of partial/complete proximal hamstring tears were compared. We hypothesize that operative treatment of these tears leads to better clinical and functional results...
February 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28318001/contrasting-diffusion-behaviors-of-o-and-f-atoms-on-graphene-and-within-bilayer-graphene
#3
Seho Yi, Jin-Ho Choi, Hyun-Jung Kim, Chul Hong Park, Jun-Hyung Cho
Chemical modification of graphene with adatoms is of importance for nanoelectronics applications. Based on first-principles density-functional theory calculations including van der Waals interactions, we present a comparative study of the diffusion characteristics of oxygen (O) and fluorine (F) atoms both on graphene and between the layers of bilayer graphene. We find that the calculated diffusion barrier for the O atom increases slightly from 0.81 eV on graphene to 0.85 eV within bilayer graphene, while that for the F atom largely decreases from 0...
March 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28306502/pacer-mediates-the-function-of-class-iii-pi3k-and-hops-complexes-in-autophagosome-maturation-by-engaging-stx17
#4
Xiawei Cheng, Xiuling Ma, Xianming Ding, Lin Li, Xiao Jiang, Zhirong Shen, She Chen, Wei Liu, Weihua Gong, Qiming Sun
Class III PI3-kinase (PI3KC3) is essential for autophagy initiation, but whether PI3KC3 participates in other steps of autophagy remains unknown. The HOPS complex mediates the fusion of intracellular vesicles to lysosome, but how HOPS specifically tethers autophagosome to lysosome remains elusive. Here, we report Pacer (protein associated with UVRAG as autophagy enhancer) as a regulator of autophagy. Pacer localizes to autophagic structures and positively regulates autophagosome maturation. Mechanistically, Pacer antagonizes Rubicon to stimulate Vps34 kinase activity...
March 16, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28306265/room-temperature-magneto-dielectric-effect-in-laga0-7fe0-3o3-%C3%AE-origin-and-impact-of-excess-oxygen
#5
Hari Mohan Rai, Preetam Singh, Shailendra K Saxena, Vikash Mishra, M Kamal Warshi, Rajesh Kumar, Parasmani Rajput, Archna Sagdeo, Indrani Choudhuri, Biswarup Pathak, Pankaj R Sagdeo
We report an observation of room-temperature magneto-dielectric (RTMD) effect in LaGa0.7Fe0.3O3+γ compound. The contribution of intrinsic/resistive sources in the presently observed RTMD effect was analyzed by measuring direct-current (dc) magnetoresistance (MR) in four-probe geometry and frequency-dependent MR via impedance spectroscopy (MRIS). Present MRIS analysis reveals that at frequencies corresponding to grain contribution (≥1 × 10(6) Hz for present sample), the observed MD phenomenon is MR-free/intrinsic, whereas at lower probing frequencies (<1 × 10(6) Hz), the observed MD coupling appears to be MR-dominated possibly due to oxygen excess, that is, due to coexistence of Fe(3+) and Fe(4+)...
March 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28301433/a-comparison-of-bilateral-muscular-imbalance-ratio-calculations-using-functional-tests
#6
Theodoros M Bampouras, Susan Dewhurst
Bilateral muscular imbalance can increase the risk of injury and negatively impact sporting performance. Bilateral muscular imbalances are typically calculated as ((side 1-side 2)/reference value) x 100, to provide a percentage value of the difference between limbs. Using different numerator (right-left or strong-weak) or reference values (left, right, strong, weak, average of the two) could mask or inflate the true difference value. The present study aimed to compare the bilateral muscular imbalance ratio calculations, using the absolute difference between limbs as the numerator and the five different options as reference values...
March 13, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28298066/effect-of-fatigue-protocols-on-lower-limb-neuromuscular-function-and-implications-for-anterior-cruciate-ligament-injury-prevention-training
#7
Sue D Barber-Westin, Frank R Noyes
BACKGROUND: Approximately two-thirds of anterior cruciate ligament (ACL) tears are sustained during noncontact situations when an athlete is cutting, pivoting, decelerating, or landing from a jump. Some investigators have postulated that fatigue may result in deleterious alterations in lower limb biomechanics during these activities that could increase the risk of noncontact ACL injuries. However, prior studies have noted a wide variation in fatigue protocols, athletic tasks studied, and effects of fatigue on lower limb kinetics and kinematics...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28291516/a-practical-solution-to-reduce-soft-tissue-artifact-error-at-the-knee-using-adaptive-kinematic-constraints
#8
Brigitte M Potvin, Mohammad S Shourijeh, Kenneth B Smale, Daniel L Benoit
Musculoskeletal modeling and simulations have vast potential in clinical and research fields, but face various challenges in representing the complexities of the human body. Soft tissue artifact from skin-mounted markers may lead to non-physiological representation of joint motions being used as inputs to models in simulations. To address this, we have developed adaptive joint constraints on five of the six degree of freedom of the knee joint based on in vivo tibiofemoral joint motions recorded during walking, hopping and cutting motions from subjects instrumented with intra-cortical pins inserted into their tibia and femur...
February 21, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28289735/dielectric-relaxation-and-localized-electron-hopping-in-colossal-dielectric-nb-in-doped-tio2-rutile-nanoceramics
#9
Kosuke Tsuji, HyukSu Han, Sophie Guillemet-Fritsch, Clive A Randall
Dielectric spectroscopy was performed on a Nb and In co-doped rutile TiO2 nano-crystalline ceramic (n-NITO) synthesized by a low-temperature spark plasma sintering (SPS) technique. The dielectric properties of the n-NITO were not largely affected by the metal electrode contacts. Huge dielectric relaxation was observed at a very low temperature below 35 K. Both the activation energy and relaxation time suggested that the electronic hopping motion is the underlying mechanism responsible for the colossal dielectric permittivity (CP) and its relaxation, instead of the internal barrier layer effect or a dipolar relaxation...
March 14, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28280907/high-prevalence-of-knee-osteoarthritis-at-a-minimum-10-year-follow-up-after-knee-dislocation-surgery
#10
Gilbert Moatshe, Grant J Dornan, Tom Ludvigsen, Sverre Løken, Robert F LaPrade, Lars Engebretsen
PURPOSE: Long-term outcomes and the prevalence of osteoarthritis after surgical treatment of knee dislocations are lacking in the literature. The purpose of this study was to investigate the prevalence of knee osteoarthritis and knee function at a minimum of 10 years after knee dislocation surgery. METHODS: Sixty-five patients surgically treated for knee dislocations at a single level I trauma center between May 1996 and December 2004 were evaluated at a minimum of 10 years...
March 9, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28272344/nutritional-and-metabolic-derangements-in-pancreatic-cancer-and-pancreatic-resection
#11
REVIEW
Taylor M Gilliland, Nicole Villafane-Ferriol, Kevin P Shah, Rohan M Shah, Hop S Tran Cao, Nader N Massarweh, Eric J Silberfein, Eugene A Choi, Cary Hsu, Amy L McElhany, Omar Barakat, William Fisher, George Van Buren
Pancreatic cancer is an aggressive malignancy with a poor prognosis. The disease and its treatment can cause significant nutritional impairments that often adversely impact patient quality of life (QOL). The pancreas has both exocrine and endocrine functions and, in the setting of cancer, both systems may be affected. Pancreatic exocrine insufficiency (PEI) manifests as weight loss and steatorrhea, while endocrine insufficiency may result in diabetes mellitus. Surgical resection, a central component of pancreatic cancer treatment, may induce or exacerbate these dysfunctions...
March 7, 2017: Nutrients
https://www.readbyqxmd.com/read/28267347/structural-evolution-of-gold-clusters-aun-n-21-25-revisited
#12
Navneet Singh Khetrapal, Satya S Bulusu, Xiao Cheng Zeng
We performed a combined theoretical and experimental photoelectron spectroscopy study of the structural evolution of gold anion clusters Aun(-) in the size range n = 21-25, a special size range for gold anion clusters where extensive structural changes from the pyramidal structure at Au20(-) toward the core-shell structure at Au26(-) were expected to occur. Density functional theory calculations with inclusion of spin-orbit effects were employed to produce the simulated spectra for the selected low-energy isomers obtained from basin-hopping global minimum search...
March 21, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28264835/ift56-regulates-vertebrate-developmental-patterning-by-maintaining-iftb-integrity-and-ciliary-microtubule-architecture
#13
Daisy Xin, Kasey J Christopher, Lewie Zeng, Yong Kong, Scott D Weatherbee
Cilia are key regulators of animal development and depend on intraflagellar transport (IFT) proteins to form and function, yet the roles of individual IFTs are still unclear. We examined the Ift56(hop) mouse mutant and reveal novel insight into the function of IFT56, a poorly understood IFTB protein. Ift56(hop) mice have normal cilia distribution but display defective cilia structure including abnormal positioning and number of ciliary microtubule doublets. Furthermore, we show that Ift56(hop) cilia are unable to accumulate Gli proteins efficiently, resulting in developmental patterning defects in Shh signaling-dependent tissues such as the limb and neural tube...
March 6, 2017: Development
https://www.readbyqxmd.com/read/28259462/standardization-proposal-of-soft-tissue-artefact-description-for-data-sharing-in-human-motion-measurements
#14
Andrea Cereatti, Tecla Bonci, Massoud Akbarshahi, Kamiar Aminian, Arnaud Barré, Mickael Begon, Daniel L Benoit, Caecilia Charbonnier, Fabien Dal Maso, Silvia Fantozzi, Cheng-Chung Lin, Tung-Wu Lu, Marcus G Pandy, Rita Stagni, Antonie J van den Bogert, Valentina Camomilla
Soft tissue artefact (STA) represents one of the main obstacles for obtaining accurate and reliable skeletal kinematics from motion capture. Many studies have addressed this issue, yet there is no consensus on the best available bone pose estimator and the expected errors associated with relevant results. Furthermore, results obtained by different authors are difficult to compare due to the high variability and specificity of the phenomenon and the different metrics used to represent these data. Therefore, the aim of this study was twofold: firstly, to propose standards for description of STA; and secondly, to provide illustrative STA data samples for body segments in the upper and lower extremities and for a range of motor tasks specifically, level walking, stair ascent, sit-to-stand, hip- and knee-joint functional movements, cutting motion, running, hopping, arm elevation and functional upper-limb movements...
February 21, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28259374/supplemental-oxygen-during-hypothermic-kidney-preservation-a-systematic-review
#15
REVIEW
J M O'Callaghan, K T Pall, Lhm Pengel
We reviewed the evidence for ex-vivo Supplemental Oxygen during Hypothermic preservation (SOH) for deceased donor kidneys. Bibliographic databases were searched for human and animal studies of SOH in kidney transplantation reporting on patient or animal survival rate, discard rate, technical complications or renal function outcomes. We make special reference to a specific subgroup: supplemental oxygen applied during cold perfusion, referred to as Hypothermic Oxygenated Perfusion (HOP). Four human and 25 animal studies were identified...
February 17, 2017: Transplantation Reviews
https://www.readbyqxmd.com/read/28256826/atomic-structure-and-dynamics-of-single-platinum-atom-interactions-with-monolayer-mos2
#16
Huashan Li, Shanshan Wang, Hidetake Sawada, Grace G D Han, Thomas Samuels, Christopher S Allen, Angus I Kirkland, Jeffrey C Grossman, Jamie H Warner
We have studied atomic level interactions between single Pt atoms and the surface of monolayer MoS2 using aberration-corrected annular dark field scanning transmission electron microscopy at an accelerating voltage of 60 kV. Strong contrast from single Pt atoms on the atomically resolved monolayer MoS2 lattice enables their exact position to be determined with respect to the MoS2 lattice, revealing stable binding sites. In regions of MoS2 free from surface contamination, the Pt atoms are localized in S vacancy sites and exhibit dynamic hopping to nearby vacancy sites driven by the energy supplied by the electron beam...
March 3, 2017: ACS Nano
https://www.readbyqxmd.com/read/28255567/an-ecological-study-of-anterior-cruciate-ligament-reconstruction-part-2-functional-performance-tests-correlate-with-return-to-sport-outcomes
#17
Timothy M McGrath, Gordon Waddington, Jennie M Scarvell, Nick Ball, Rob Creer, Kevin Woods, Damian Smith, Roger Adams
BACKGROUND: Additional high-quality prospective studies are needed to better define the objective criteria used in relation to return-to-sport decisions after anterior cruciate ligament (ACL) reconstruction in active populations. PURPOSE: To investigate prospectively the relationship between functional performance test results at 24 weeks postoperative and return-to-sport activity (Tegner activity score) at 12 and 24 months, respectively, after synthetic (ligament advanced reinforcement system [LARS]) and autograft (doubled semitendinosus/gracilis [2ST/2GR]) ACL reconstructions...
February 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28255565/defining-the-long-toss-a-professional-baseball-epidemiological-study
#18
Austin V Stone, Sandeep Mannava, Anita Patel, Alejandro Marquez-Lara, Michael T Freehill
BACKGROUND: Despite widespread use of long-toss throwing in baseball as a component of arm conditioning, interval throwing programs, and rehabilitation, long-toss distance and throwing mechanics remain controversial. PURPOSE: To ascertain the perceived definition of long-toss throwing through a survey of professional pitchers, pitching coaches (PCs), and certified athletic trainers (ATCs) associated with Major League Baseball. STUDY DESIGN: Descriptive epidemiology study...
February 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28252249/the-isoxazole-ring-and-its-n-oxide-a-privileged-core-structure-in-neuropsychiatric-therapeutics
#19
REVIEW
George N Pairas, Fereniki Perperopoulou, Petros G Tsoungas, George Varvounis
Mental disorders are neuropsychiatric conditions that are marked by unusual or irregular thinking, feelings, or behavior, and lead to distress and/or impaired functions. Major psychiatric conditions are depression, anxiety, and psychoses of various types. Their etiopathogeneses, of a primary or secondary origin, are associated with genetic and environmental factors. They are commonly treated with psychoactive drugs (also known as psychotropics), which target serotonin, dopamine, norepinephrine, glutamate, and nuclear receptors (NRs), including retinoic acid receptor-related orphan receptors (RORs) and other receptors in the central nervous system (CNS)...
March 2, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28249440/microscopic-origin-of-the-fragile-to-strong-crossover-in-supercooled-water-the-role-of-activated-processes
#20
M De Marzio, G Camisasca, M Rovere, P Gallo
We perform an accurate analysis of the density self-correlation functions of TIP4P/2005 supercooled water on approaching the region of the liquid-liquid critical point. In a previous work on this model, we provided evidence of a fragile to strong crossover of the dynamical behavior in the deep supercooled region. The structural relaxation follows the Mode Coupling theory in the fragile region and then deviates from Mode Coupling regime to a strong Arrhenius behavior. This crossover is particularly important in water because it is connected to the thermodynamics of the supercooled region...
February 28, 2017: Journal of Chemical Physics
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