Read by QxMD icon Read

Functional Hops

Hop V Phan, Richard Wickham, Sihuang Xie, James A McDonald, Stuart J Khan, Hao H Ngo, Wenshan Guo, Long D Nghiem
A pilot-scale study was conducted to investigate the fate of trace organic contaminants (TrOCs) during anaerobic digestion of primary sludge. Of the 44 TrOCs monitored, 24 were detected in all primary sludge samples. Phase distribution of TrOCs was correlated well with their hydrophobicity (>67% mass in the solid phase when LogD > 1.5). The pilot-scale anaerobic digester achieved a steady performance with a specific methane yield of 0.39-0.92 L/gVSremoved and methane composition of 63-65% despite considerable variation in the primary sludge...
February 10, 2018: Bioresource Technology
Bodil A Bluhm, Haakon Hop, Mikko Vihtakari, Rolf Gradinger, Katrin Iken, Igor A Melnikov, Janne E Søreide
Arctic sea ice provides microhabitats for biota that inhabit the liquid-filled network of brine channels and the ice-water interface. We used meta-analysis of 23 published and unpublished datasets comprising 721 ice cores to synthesize the variability in composition and abundance of sea ice meiofauna at spatial scales ranging from within a single ice core to pan-Arctic and seasonal scales. Two-thirds of meiofauna individuals occurred in the bottom 10 cm of the ice. Locally, replicate cores taken within meters of each other were broadly similar in meiofauna composition and abundance, while those a few km apart varied more; 75% of variation was explained by station...
February 2018: Ecology and Evolution
Andrea N Kravats, Joel R Hoskins, Michael Reidy, Jill L Johnson, Shannon M Doyle, Olivier Genest, Daniel C Masison, Sue Wickner
Heat shock protein 90 (Hsp90) is a highly conserved ATP-dependent molecular chaperone that is essential in eukaryotes. It is required for the activation and stabilization of more than 200 client proteins, including many kinases and steroid hormone receptors involved in cell-signaling pathways. Hsp90 chaperone activity requires collaboration with a subset of the many Hsp90 cochaperones, including the Hsp70 chaperone. In higher eukaryotes, the collaboration between Hsp90 and Hsp70 is indirect and involves Hop, a cochaperone that interacts with both Hsp90 and Hsp70...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
Kodai Takemoto, Kazuo Ebine, Jana Christin Askani, Falco Krüger, Zaida Andrés Gonzalez, Emi Ito, Tatsuaki Goh, Karin Schumacher, Akihiko Nakano, Takashi Ueda
Membrane trafficking plays pivotal roles in various cellular activities and higher-order functions of eukaryotes and requires tethering factors to mediate contact between transport intermediates and target membranes. Two evolutionarily conserved tethering complexes, homotypic fusion and protein sorting (HOPS) and class C core vacuole/endosome tethering (CORVET), are known to act in endosomal/vacuolar transport in yeast and animals. Both complexes share a core subcomplex consisting of Vps11, Vps18, Vps16, and Vps33, and in addition to this core, HOPS contains Vps39 and Vps41, whereas CORVET contains Vps3 and Vps8...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
Jong-Kwon Ha, In Seong Lee, Seung Kyu Min
Description of correct electron-nuclear couplings is crucial in modelling of nonadiabatic dynamics. Within traditional semiclassical or mixed quantum-classical dynamics, the coupling between quantum electronic states and classical nuclear trajectories is governed by nonadiabatic coupling vectors coupled to classical nuclear momenta. This enables us to develop a very powerful nonadiabatic dynamics algorithm, namely surface hopping dynamics, which can describe the splitting of nuclear wave packets and detailed balance...
February 13, 2018: Journal of Physical Chemistry Letters
Daan T van Yperen, Max Reijman, Eline M van Es, Sita M A Bierma-Zeinstra, Duncan E Meuffels
BACKGROUND: An anterior cruciate ligament (ACL) rupture has major consequences at midterm follow-up, with an increasing chance of developing an old knee in a young patient. The long-term (≥20 years) effects of the operative and nonoperative treatment of ACL ruptures are still unclear. PURPOSE: To compare the long-term treatment outcomes of operative versus nonoperative treatment of ACL ruptures in high-level athletes. STUDY DESIGN: Cohort study; Level of evidence, 2...
February 1, 2018: American Journal of Sports Medicine
Vala Flosadottir, Richard Frobell, Ewa M Roos, Eva Ageberg
BACKGROUND: In people with anterior cruciate ligament (ACL) injury, high self-efficacy facilitates recovery, indicated by improved muscle function, reduced knee symptoms and increased physical activity. Impact of treatment on future self-efficacy is however not well investigated. The aims of the study were to 1) investigate knee-related self-efficacy 6 years after acute ACL injury in patients treated with exercise therapy alone or in combination with either early or the option of delayed ACL reconstruction (ACLR), and 2) to investigate associations between single-leg physical performance at various time points after ACL injury and knee self-efficacy at 6 years after injury...
February 13, 2018: BMC Musculoskeletal Disorders
Divya Srinivasan, Eva Tengman, Charlotte K Häger
BACKGROUND: Recent studies highlight the need for understanding movement control of adjacent joints when evaluating knee function following anterior cruciate ligament (ACL) injury. However, while short-term adaptations to lower-extremity joint coupling have been studied, little is known about any potential long-term adaptations in neuromuscular control displayed by ACL-injured individuals. The aim of our study was to determine whether coordination variability of the hip-knee joint couplings during the one-leg hop is altered about 20 years after injury in two ACL-injured groups compared to healthy knee controls...
February 6, 2018: Clinical Biomechanics
Mathijs A M Suijkerbuijk, Max Reijman, Edwin H G Oei, Belle L van Meer, Ewoud R A van Arkel, Duncan E Meuffels
BACKGROUND: Semitendinosus and gracilis tendons may regenerate after harvesting for ligament reconstruction procedures. However, predictive factors of tendon regeneration and the extent of functional recovery remain unclear. PURPOSE: To identify predictive factors for hamstring tendon regeneration and to examine the morbidity of nonregenerated hamstring tendons. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: Of the 154 patients who were included in a prospective follow-up study, 79 underwent reconstruction of the anterior cruciate ligament entailing the hamstring tendons and met the following inclusion criteria: (1) anterior cruciate ligament rupture diagnosed by physical examination and magnetic resonance imaging (MRI), (2) MRI within 6 months after trauma, (3) age between 18 and 45 years, and (4) 2-year follow-up MRI data available...
February 1, 2018: American Journal of Sports Medicine
J Chris Coetzee, J Kent Ellington, James A Ronan, Rebecca M Stone
BACKGROUND: The Broström procedure is the most commonly used lateral ligament repair for chronic instability, but there is concern about the strength of the repair and the risk of reinjury. Currently, the InternalBraceTM ligament augmentation repair is an accepted augmentation method for management of a Broström procedure. Our hypothesis was that augmentation of the Broström repair with an InternalBraceTM would allow accelerated rehabilitation and return to activity and would aid in stability of the repair without a tendency to stretch...
February 1, 2018: Foot & Ankle International
Jae-Min Cho, Sun-Mi Yun, Young-Ho Choi, Jinyuk Heo, Nam-Jung Kim, Seok-Ho Kim, Eun-Hee Kim
Xanthohumol (XN), a prenylated chalcone isolated from the hop plant, has been reported to exhibit multiple biological functions including anti-inflammation. However, the pharmacological function of XN on colitis remains unknown. In this study, we investigated the anti-inflammatory effect of synthesized XN and molecular mechanism on dextran sulfate sodium (DSS)-induced experimental colitis. XN attenuated the colitis symptoms along with the prevention of colonic lesions after DSS challenge. XN inhibited the production of pro-inflammatory cytokines, oxidative stress and cyclooxygenase-2 expression in DSS-treated mice...
January 2, 2018: Oncotarget
Zhigang Jin, Ning Wang, Yishan Su, Qiuling Yang
Underwater acoustic sensor networks (UASNs) have become a hot research topic. In UASNs, nodes can be affected by ocean currents and external forces, which could result in sudden link disruption. Therefore, designing a flexible and efficient link disruption restoration mechanism to ensure the network connectivity is a challenge. In the paper, we propose a glider-assisted restoration mechanism which includes link disruption recognition and related link restoring mechanism. In the link disruption recognition mechanism, the cluster heads collect the link disruption information and then schedule gliders acting as relay nodes to restore the disrupted link...
February 7, 2018: Sensors
Chunmei Zhang, Yalong Jiao, Tianwei He, Steven E Bottle, Thomas Frauenheim, Aijun Du
The interlayer coupling in two-dimensional (2D) van der Waals (vdW) heterostructures (HTS) plays the main role in generating new physics. However, the interlayer coupling is often weak and little information on the strength of interlayer interaction in HTS is available. Based on density functional theory, we demonstrate that an effective electron coupling can be created in 2D C3B/C3N vdW HTS. The experimentally synthesised monolayer C3B and C3N, are p- and n-typed doped large gap semiconductors, respectively...
February 6, 2018: Journal of Physical Chemistry Letters
Eric Hamrin Senorski, Eleonor Svantesson, Susanne Beischer, Christoffer Thomeé, Alberto Grassi, Ferid Krupic, Roland Thomeé, Jón Karlsson, Kristian Samuelsson
PURPOSE: A better understanding of patient characteristics and the way common concomitant injuries affect the recovery of muscle function after surgery should help providers to treat patients with anterior cruciate ligament (ACL) injuries. The aim of this study was to determine whether patient characteristics, concomitant injuries and graft choice at ACL reconstruction were associated with symmetrical knee muscle function at one year. The hypothesis was that the presence of concomitant injuries would negatively influence the opportunity to achieve symmetrical knee function at the one-year follow-up...
February 5, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
André F Guerra, Caroline Mellinger-Silva, Amauri Rosenthal, Rosa H Luchese
The aim of this research was to investigate the effect of Holder pasteurization (HoP; 62.5°C, 30 min) on the protein profile and activities of glutathione peroxidase (GPx) and lysozyme (LZ) in human milk. Over 6 mo of lactation, human milk samples were analyzed before (raw) and after HoP for GPx and LZ activity and electrophoresis protein profile. Holder pasteurization reduced human milk lactoferrin, immunoglobulin fractions, and GPx activity. In addition, GPx activity, which is high in colostrum and transitional milk, was naturally reduced over the 6-mo lactation period...
January 31, 2018: Journal of Dairy Science
Tolga N V Karsili, Barbara Marchetti, Spiridoula Matsika
4-Hydroxybenzothiazole (HBT) is a molecular constituent of pheomelanin $-$ a polymeric skin centered pigment which acts as a natural photoprotector against harmful solar-UV radiation. Its molecular structure is therefore required to sustain a degree of photostability upon electronic excitation with UV irradiation. Despite its function as a protector against UV, pheomelanin is known to be less photostable than that of its close derivative eumelanin - a dark skin centered pigment. The HBT subunit has long being attributed as a key contributor to the lack of photostability of pheomelanin - a hypothesis which we aim to test in this manuscript...
February 2, 2018: Journal of Physical Chemistry. A
Panagiotis Krokidas, Salvador Moncho, Edward N Brothers, Marcelo Castier, Ioannis G Economou
The influence of a zeolitic imidazolate framework (ZIF)'s metal identity on its gas separation performance is studied extensively through molecular simulations for a variety of gases. ZIF-8 is used as the original framework for alterations of different metal substitutes of the Zn2+ metal. ZIF-8 consists of cages connected by narrow apertures that exhibit flexibility through "swelling", allowing for relatively large penetrants to diffuse. Replacing the central metal atom in the basic tetrahedral unit of ZIF-8 with Cd, Co or Be results in three different structures with increasing bonding stiffness with their neighboring atoms...
January 31, 2018: Physical Chemistry Chemical Physics: PCCP
Harilton da Silva Araújo, Raimir Holanda Filho, Joel J P C Rodrigues, Ricardo de A L Rabelo, Natanael de C Sousa, José C C L S Filho, José V V Sobral
The Internet of Things (IoT) is based on interconnection of intelligent and addressable devices, allowing their autonomy and proactive behavior with Internet connectivity. Data dissemination in IoT usually depends on the application and requires context-aware routing protocols that must include auto-configuration features (which adapt the behavior of the network at runtime, based on context information). This paper proposes an approach for IoT route selection using fuzzy logic in order to attain the requirements of specific applications...
January 26, 2018: Sensors
Liangliang Wang, Wei Si, Huping Xue, Xin Zhao
Background: ISSau2 has been suggested as a member of the IS150 f subgroup in the IS3 family. It encodes a fusion transposase OrfAB produced by programmed - 1 translational frameshifting with two overlapping reading frames orfA and orfB. To better characterize ISSau2, the binding and cleaving activities of the ISSau2 transposase and its transposition frequency were studied. Results: The purified ISSau2 transposase OrfAB was a functional protein in vitro since it bound specifically to ISSau2 terminal inverted repeat sequences (IRs) and cleaved the transposon ends at the artificial mini-transposon pUC19-IRL-gfp-IRR...
2018: Mobile DNA
Caroline Lisee, Lindsay Slater, Jay Hertel, Joe M Hart
CONTEXT: Strength, functional performance and limb symmetry are common objective clinical assessments used by clinicians to guide safe return to physical activity following injury. Population-specific unilateral limb outcomes or estimates of limb symmetry of these assessments should be established. OBJECTIVE: To compare lower extremity strength, functional performance and limb symmetry in healthy participants based on sex and level of activity. DESIGN: Descriptive laboratory study Setting: Laboratory Participants: 117 healthy participants (72 males/45 females, mass=73...
January 24, 2018: Journal of Sport Rehabilitation
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"