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Functional Hops

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https://www.readbyqxmd.com/read/28644677/young-athletes-after-anterior-cruciate-ligament-reconstruction-with-single-leg-landing-asymmetries-at-the-time-of-return-to-sport-demonstrate-decreased-knee-function-2-years-later
#1
Matthew P Ithurburn, Mark V Paterno, Kevin R Ford, Timothy E Hewett, Laura C Schmitt
BACKGROUND: Previous work shows that young athletes after anterior cruciate ligament reconstruction (ACLR) demonstrate single-leg (SL) landing movement asymmetries at the time of return to sport (RTS); however, the effect of movement asymmetries on longitudinal knee-related function after ACLR has not been examined. Hypothesis/Purpose: The purpose of this study was to examine the effect of SL drop-landing movement symmetry at the time of RTS on knee-related function 2 years later in young athletes after ACLR...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28637767/a-short-region-upstream-of-the-yeast-vacuolar-qa-snare-heptad-repeats-promotes-membrane-fusion-through-enhanced-snare-complex-assembly
#2
Hongki Song, William Wickner
While SNARE heptad-repeats are well studied, SNAREs also have upstream N-domains of indeterminate function. The assembly of yeast vacuolar SNAREs into complexes for fusion can be studied in chemically-defined reactions. Complementary proteoliposomes bearing a Rab:GTP and either the vacuolar R-SNARE or one of the 3 integrally-anchored Q-SNAREs were incubated with the tethering/SM protein complex HOPS and the two other soluble SNAREs (lacking a trans-membrane anchor) or their SNARE heptad-repeat domains. Fusion required a trans-membrane anchored R-SNARE on one membrane and an anchored Q-SNARE on the other...
June 21, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28628950/flexible-fused-azomethine-boron-complex-thermochromic-luminescence-and-thermosalient-behaviors-in-structural-transitions-between-crystalline-polymorphs
#3
Shunsuke Ohtani, Masayuki Gon, Kazuo Tanaka, Yoshiki Chujo
This manuscript reports the multi-functional boron complex presenting aggregation-induced emission (AIE), crystallization-induced emission enhancement (CIEE) and thermosalient behaviors accompanying thermochromic luminescence during crystal-crystal transitions by employing the fused azomethine ligand. In particular, we propose that these properties can be explained by molecular "flexibility" toward external stimuli including temperature changes and photo-excitation, and two types of crystal polymorphs having different absorption and luminescent properties were obtained...
June 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28627889/measuring-spatially-resolved-collective-ionic-transport-on-lithium-battery-cathodes-using-atomic-force-microscopy
#4
Aaron Mascaro, Zi Wang, Pierre Hovington, Yoichi Miyahara, Andrea Paolella, Vincent Gariepy, Zimin Feng, Tyler Enright, Connor Aiken, Karim Zaghib, Kirk H Bevan, Peter Grutter
One of the main challenges in improving fast charging lithium-ion batteries is the development of suitable active materials for cathodes and anodes. Many materials suffer from unacceptable structural changes under high currents and/or low intrinsic conductivities. Experimental measurements are required to optimize these properties, but few techniques are able to spatially resolve ionic transport properties at small length scales. Here we demonstrate an atomic force microscope (AFM)-based technique to measure local ionic transport on LiFePO4 to correlate with the structural and compositional analysis of the same region...
June 21, 2017: Nano Letters
https://www.readbyqxmd.com/read/28620086/a-genetic-screen-reveals-an-unexpected-role-for-yorkie-signaling-in-jak-stat-dependent-hematopoietic-malignancies-in-drosophila-melanogaster
#5
Abigail M Anderson, Alessandro A Bailetti, Elizabeth Rodkin, Atish De, Erika A Bach
A gain-of-function mutation in the tyrosine kinase JAK2 (JAK2(V617F) ) causes human myeloproliferative neoplasms (MPNs). These patients present with high numbers of myeloid lineage cells and have numerous complications. Since current MPN therapies are not curative, there is a need to find new regulators and targets of JAK/STAT signaling that may represent additional clinical interventions. Drosophila melanogaster offers a low complexity model to study MPNs as JAK/STAT signaling is simplified with only one JAK (Hopscotch (Hop)) and one STAT (Stat92E)...
June 15, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28618561/capturing-brownian-dynamics-with-an-on-lattice-model-of-hard-sphere-diffusion
#6
Claudia Cianci, Stephen Smith, Ramon Grima
Conventional master equation approaches approximate the diffusion of molecules in continuum space by the process of particles hopping on a spatial lattice. The hopping probability from one voxel (spatial lattice point) to its neighbor is usually considered to be constant throughout space. Such an assumption is only consistent with pointlike molecules and thus neglects volume-exclusion effects due to finite particle size. A few studies have attempted to introduce volume-exclusion effects by choosing the hopping probability from one voxel to a neighboring one to be a linear function of the number density...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28607220/the-role-of-short-range-magnetic-correlations-in-the-gap-opening-of-topological-kondo-insulators
#7
Edwin Rodriguez, Roberto Franco Penaloza, Jereson Valencia, M Foglio, M S Figueira
In this article we investigate the effects of short-range anti-ferromagnetic correlations on the gap opening of topological Kondo insulators. We add a Heisenberg term to the periodic Anderson model at the limit of strong correlations in order to allow a small degree of hopping of the localized electrons between neighboring sites of the lattice. This new model is adequate for studying topological Kondo insulators, whose paradigmatic material is the compound SmB6. The main finding of the article is that the short-range antiferromagnetic correlations, present in some Kondo insulators, contribute decisively to the opening of the Kondo gap in their density of states...
June 13, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28596973/quadriceps-strength-in-patients-with-isolated-cartilage-defects-of-the-knee-results-of-isokinetic-strength-measurements-and-their-correlation-with-clinical-and-functional-results
#8
Anja Hirschmüller, Tasja Andres, Wolfgang Schoch, Heiner Baur, Lukas Konstantinidis, Norbert P Südkamp, Philipp Niemeyer
BACKGROUND: Recent studies have found a significant deficit of maximum quadriceps strength after autologous chondrocyte implantation (ACI) of the knee. However, it is unclear whether muscular strength deficits in patients with cartilage damage exist prior to operative treatment. PURPOSE: To isokinetically test maximum quadriceps muscle strength and quantify the impact of possible strength deficits on functional and clinical test results. STUDY DESIGN: Cross-sectional study; Level of evidence, 3...
May 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28567003/evidence-of-a-cell-surface-role-for-hsp90-complex-proteins-mediating-neuroblast-migration-in-the-subventricular-zone
#9
Leo M Miyakoshi, Diego Marques-Coelho, Luiz E R De Souza, Flavia R S Lima, Vilma R Martins, Silvio M Zanata, Cecilia Hedin-Pereira
In most mammalian brains, the subventricular zone (SVZ) is a germinative layer that maintains neurogenic activity throughout adulthood. Neuronal precursors arising from this region migrate through the rostral migratory stream (RMS) and reach the olfactory bulbs where they differentiate and integrate into the local circuitry. Recently, studies have shown that heat shock proteins have an important role in cancer cell migration and blocking Hsp90 function was shown to hinder cell migration in the developing cerebellum...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28527449/correlated-matrix-fluctuation-mediated-activated-transport-of-dilute-penetrants-in-glass-forming-liquids-and-suspensions
#10
Rui Zhang, Kenneth S Schweizer
We formulate a microscopic, force-level statistical mechanical theory for the activated diffusion of dilute penetrants in dense liquids, colloidal suspensions, and glasses. The approach explicitly and self-consistently accounts for coupling between penetrant hopping and matrix dynamic displacements that actively facilitate the hopping event. The key new ideas involve two mechanistically (at a stochastic trajectory level) coupled dynamic free energy functions for the matrix and spherical penetrant particles...
May 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28515975/prospective-functional-performance-testing-and-relationship-to-lower-extremity-injury-incidence-in-adolescent-sports-participants
#11
Joseph Smith, Nick DePhillipo, Iris Kimura, Morgan Kocher, Ronald Hetzler
BACKGROUND: Due to the high number of adolescent athletes and subsequent lower extremity injuries, improvements of injury prevention strategies with emphasis on clinic-based and practical assessments are warranted. PURPOSE: The purpose of this study was to prospectively investigate if a battery of functional performance tests (FPT) could be used as a preseason-screening tool to identify adolescent athletes at risk for sports-related acute lower extremity injury via comparison of injured and uninjured subjects...
April 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28515973/intra-rater-reliability-of-the-multiple-single-leg-hop-stabilization-test-and-relationships-with-age-leg-dominance-and-training
#12
Leanne Sawle, Jennifer Freeman, Jonathan Marsden
BACKGROUND: Balance is a complex construct, affected by multiple components such as strength and co-ordination. However, whilst assessing an athlete's dynamic balance is an important part of clinical examination, there is no gold standard measure. The multiple single-leg hop-stabilization test is a functional test which may offer a method of evaluating the dynamic attributes of balance, but it needs to show adequate intra-tester reliability. PURPOSE: The purpose of this study was to assess the intra-rater reliability of a dynamic balance test, the multiple single-leg hop-stabilization test on the dominant and non-dominant legs...
April 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28507672/mechanism-of-photocatalytic-water-oxidation-on-small-tio2-nanoparticles
#13
Mikko Muuronen, Shane M Parker, Enrico Berardo, Alexander Le, Martijn A Zwijnenburg, Filipp Furche
We present the first unconstrained nonadiabatic molecular dynamics (NAMD) simulations of photocatalytic water oxidation by small hydrated TiO2 nanoparticles using Tully surface hopping and time-dependent density functional theory. The results indicate that ultrafast electron-proton transfer from physisorbed water to the photohole initiates the photo-oxidation on the S1 potential energy surface. The new mechanism readily explains the observation of mobile hydroxyl radicals in recent experiments. Two key driving forces for the photo-oxidation reaction are identified: localization of the electron-hole pair and stabilization of the photohole by hydrogen bonding interaction...
March 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28496411/calf-compression-sleeves-change-biomechanics-but-not-performance-and-physiological-responses-in-trail-running
#14
Hugo A Kerhervé, Pierre Samozino, Fabrice Descombe, Matthieu Pinay, Guillaume Y Millet, Marion Pasqualini, Thomas Rupp
Introduction: The aim of this study was to determine whether calf compression sleeves (CS) affects physiological and biomechanical parameters, exercise performance, and perceived sensations of muscle fatigue, pain and soreness during prolonged (~2 h 30 min) outdoor trail running. Methods: Fourteen healthy trained males took part in a randomized, cross-over study consisting in two identical 24-km trail running sessions (each including one bout of running at constant rate on moderately flat terrain, and one period of all-out running on hilly terrain) wearing either degressive CS (23 ± 2 mmHg) or control sleeves (CON, <4 mmHg)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28494336/metabolite-profiling-of-flavonols-and-in-vitro-antioxidant-activity-of-young-shoots-of-wild-humulus-lupulus-l-hop
#15
Annalisa Maietti, Virginia Brighenti, Gianpiero Bonetti, Paola Tedeschi, Francesco Pio Prencipe, Stefania Benvenuti, Vincenzo Brandolini, Federica Pellati
Humulus lupulus L., commonly named hop, is well-known for its sedative and estrogenic activity. While hop cones are widely characterized, only few works have been carried out on the young shoots of this plant. In the light of this, the aim of this study was to identify for the first time the flavonoids present in young hop shoots and to compare the composition of samples harvested from different locations in Northern Italy with their antioxidant activity. The samples were extracted by means of dynamic maceration with methanol...
April 29, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28492364/na-influx-via-orai1-inhibits-intracellular-atp-induced-mtorc2-signaling-to-disrupt-cd4-t-cell-gene-expression-and-differentiation
#16
Yong Miao, Jaya Bhushan, Adish Dani, Monika Vig
T cell effector functions require sustained calcium influx. However, the signaling and phenotypic consequences of non-specific sodium permeation via calcium channels remain unknown. α-SNAP is a crucial component of Orai1 channels, and its depletion disrupts the functional assembly of Orai1 multimers. Here we show that α-SNAP hypomorph, hydrocephalus with hopping gait, Napa(hyh/hyh) mice harbor significant defects in CD4 T cell gene expression and Foxp3 regulatory T cell (Treg) differentiation. Mechanistically, TCR stimulation induced rapid sodium influx in Napa(hyh/hyh) CD4 T cells, which reduced intracellular ATP, [ATP]i...
May 11, 2017: ELife
https://www.readbyqxmd.com/read/28483915/rab2-promotes-autophagic-and-endocytic-lysosomal-degradation
#17
Péter Lőrincz, Sarolta Tóth, Péter Benkő, Zsolt Lakatos, Attila Boda, Gábor Glatz, Martina Zobel, Sara Bisi, Krisztina Hegedűs, Szabolcs Takáts, Giorgio Scita, Gábor Juhász
Rab7 promotes fusion of autophagosomes and late endosomes with lysosomes in yeast and metazoan cells, acting together with its effector, the tethering complex HOPS. Here we show that another small GTPase, Rab2, is also required for autophagosome and endosome maturation and proper lysosome function in Drosophila melanogaster We demonstrate that Rab2 binds to HOPS, and that its active, GTP-locked form associates with autolysosomes. Importantly, expression of active Rab2 promotes autolysosomal fusions unlike that of GTP-locked Rab7, suggesting that its amount is normally rate limiting...
May 8, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28481079/high-speed-scanning-ion-conductance-microscopy-for-quantitative-analysis-of-nanoscale-dynamics-of-microvilli
#18
Hiroki Ida, Yasufumi Takahashi, Akichika Kumatani, Hitoshi Shiku, Tomokazu Matsue
Observation of nanoscale structure dynamics on cell surfaces is essential to understanding cell functions. Hopping-mode scanning ion conductance microscopy (SICM) was used to visualize the topography of fragile convoluted nanoscale structures on cell surfaces under noninvasive conditions. However, conventional hopping mode SICM does not have sufficient temporal resolution to observe cell-surface dynamics in situ because of the additional time required for performing vertical probe movements of the nanopipette...
June 6, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28474952/large-deviations-of-a-tracer-in-the-symmetric-exclusion-process
#19
Takashi Imamura, Kirone Mallick, Tomohiro Sasamoto
The one-dimensional symmetric exclusion process, the simplest interacting particle process, is a lattice gas made of particles that hop symmetrically on a discrete line respecting hard-core exclusion. The system is prepared on the infinite lattice with a step initial profile with average densities ρ_{+} and ρ_{-} on the right and on the left of the origin. When ρ_{+}=ρ_{-}, the gas is at equilibrium and undergoes stationary fluctuations. When these densities are unequal, the gas is out of equilibrium and will remain so forever...
April 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28474170/muscle-function-in-osteogenesis-imperfecta-type-iv
#20
Louis-Nicolas Veilleux, Vasiliki B Darsaklis, Kathleen Montpetit, Francis H Glorieux, Frank Rauch
Results of previous studies suggest that children and adolescents with osteogenesis imperfecta (OI) type IV have muscle force deficits. However, muscle function remains to be objectively quantified in this population. This study aimed to assess upper and lower extremity muscle function in patients with OI type IV. It was carried out in the outpatient department of a pediatric orthopedic hospital; 27 individuals with OI type IV (7-21 years; 13 males), 27 age- and sex-matched individuals with OI type I, and 27 age- and sex-matched controls...
May 4, 2017: Calcified Tissue International
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