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Functional Hops

Birgit M Dietz, Shao-Nong Chen, René F Ramos Alvarenga, Huali Dong, Dejan Nikolić, Martin Biendl, Richard B van Breemen, Judy L Bolton, Guido F Pauli
Botanical dietary supplements contain multiple bioactive compounds that target numerous biological pathways. The lack of uniform standardization requirements is one reason that inconsistent clinical effects are reported frequently. The multifaceted biological interactions of active principles can be disentangled by a coupled pharmacological/phytochemical approach using specialized ("knock-out") extracts. This is demonstrated for hops, a botanical for menopausal symptom management. Employing targeted, adsorbent-free countercurrent separation, Humulus lupulus extracts were designed for pre- and postmenopausal women by containing various amounts of the phytoestrogen 8-prenylnaringenin (8-PN) and the chemopreventive constituent xanthohumol (XH)...
August 16, 2017: Journal of Natural Products
Stephan Bodkin, John Goetschius, Jay Hertel, Joe Hart
BACKGROUND: After anterior cruciate ligament reconstruction (ACLR), relationships between objective measures of muscle function and patient-reported outcomes may change over time. Examining these measures at different time frames after surgery may help develop individualized approaches to improve post-ALCR analysis. PURPOSE: To examine the associations between subjective knee function and lower-extremity muscle function in individual patients at various time points after ACLR...
July 2017: Orthopaedic Journal of Sports Medicine
Meng Zhang, Lijuan Wang, Dongping Zhong
Photolyase, a flavoenzyme containing flavin adenine dinucleotide (FAD) molecule as a catalytic cofactor, repairs UV-induced DNA damage of cyclobutane pyrimidine dimer (CPD) and pyrimidine-pyrimidone (6-4) photoproduct using blue light. The FAD cofactor, conserved in the whole protein superfamily of photolyase/cryptochromes, adopts a unique folded configuration at the active site that plays a critical functional role in DNA repair. Here, we review our comprehensive characterization of the dynamics of flavin cofactor and its repair photocycles by different classes of photolyases on the most fundamental level...
August 9, 2017: Archives of Biochemistry and Biophysics
Devinder Sandhu, Jayadri Ghosh, Callie Johnson, Jordan Baumbach, Eric Baumert, Tyler Cina, David Grant, Reid G Palmer, Madan K Bhattacharyya
In soybean, variegated flowers can be caused by somatic excision of the CACTA-type transposable element Tgm9 from Intron 2 of the DFR2 gene encoding dihydroflavonol-4-reductase of the anthocyanin pigment biosynthetic pathway. DFR2 was mapped to the W4 locus, where the allele containing Tgm9 was termed w4-m. In this study we have demonstrated that previously identified morphological mutants (three chlorophyll deficient mutants, one male sterile-female fertile mutant, and three partial female sterile mutants) were caused by insertion of Tgm9 following its excision from DFR2...
2017: PloS One
Santanu Saha, Luigi Genovese, Stefan Goedecker
The experimental discovery of borospherene, the only non-carbon fullerene observed in nature, has generated a lot of interest in the scientific community and led to the theoretical prediction of various endohedrally and exohedrally decorated borospherene. We apply Minima Hopping Method (MHM), a global geometry optimization algorithm at the density functional level to check the stability of recently proposed exohedrally decorated borospherenes M6@B40 for (M = Li, Na, K, Rb, Be, Mg, Ca, Sr, Sc and Ti). By performing short MHM runs, we find that the proposed fullerene structures are not global minima...
August 8, 2017: Scientific Reports
Chunxiang Wang, Gen Luo, Masayoshi Nishiura, Guoyong Song, Atsushi Yamamoto, Yi Luo, Zhaomin Hou
Heteroatom-functionalized polyolefins are of fundamental interest and practical importance. This has spurred investigations of the copolymerization of polar and nonpolar olefins. We report the first syndiospecific polymerization of a series of heteroatom-containing α-olefins and their copolymerization with ethylene catalyzed by half-sandwich rare-earth complexes. We have found that the interaction between a heteroatom in a functional α-olefin monomer and a rare-earth metal catalyst can significantly raise the olefin polymerization activity and thereby promote its copolymerization with ethylene...
July 2017: Science Advances
Leire Gartzia-Rivero, Jorge Bañuelos, Iñigo López-Arbeloa
The herein reported work describes the development of hierarchically-organized fluorescent nanomaterials inspired by plant antenna systems. These hybrid materials are based on nanostructured zeolitic materials (LTL zeolite) doped with laser dyes, which implies a synergism between organic and inorganic moieties. The non-interconnected channeled structure and pore dimensions (7.1 Å) of the inorganic host are ideal to order and align the allocated fluorophores inside, inferring also high thermal and chemical stability...
May 4, 2017: Materials
Xueyi He, Guangwei He, Anqi Zhao, Fei Wang, Xunli Mao, Yongheng Yin, Li Cao, Bei Zhang, Hong Wu, Zhongyi Jiang
Nafion, as a state-of-the-art solid electrolyte for proton exchange membrane fuel cells (PEMFCs), suffers from drastic decline in proton conductivity with decreasing humidity, which significantly restricts the efficient and stable operation of the fuel cell system. In this study, the proton conductivity of Nafion at low relative humidity (RH) was remarkably enhanced by incorporating multifunctional graphene oxide (GO) nanosheets as multifunctional fillers. Through surface-initiated atom transfer radical polymerization of sulfopropyl methacrylate (SPM) and poly(ethylene glycol) methyl ether methacrylate, the copolymer-grafted GO was synthesized and incorporated into the Nafion matrix, generating efficient paths at the Nafion-GO interface for proton conduction...
August 10, 2017: ACS Applied Materials & Interfaces
Z Wojnarowska, M Rams-Baron, J Knapik-Kowalczuk, A Połatyńska, M Pochylski, J Gapinski, A Patkowski, P Wlodarczyk, M Paluch
In this paper the relaxation dynamics of ionic glass-former acebutolol hydrochloride (ACB-HCl) is studied as a function of temperature and pressure by using dynamic light scattering and broadband dielectric spectroscopy. These unique experimental data provide the first direct evidence that the decoupling between the charge transport and structural relaxation exists in proton conductors over a wide T-P thermodynamic space, with the time scale of structural relaxation being constant at the liquid-glass transition (τα = 1000 s)...
August 1, 2017: Scientific Reports
Nadeem Javaid, Farwa Ahmed, Zahid Wadud, Nabil Alrajeh, Mohamad Souheil Alabed, Manzoor Ilahi
Underwater wireless sensor networks (UWSNs) facilitate a wide range of aquatic applications in various domains. However, the harsh underwater environment poses challenges like low bandwidth, long propagation delay, high bit error rate, high deployment cost, irregular topological structure, etc. Node mobility and the uneven distribution of sensor nodes create void holes in UWSNs. Void hole creation has become a critical issue in UWSNs, as it severely affects the network performance. Avoiding void hole creation benefits better coverage over an area, less energy consumption in the network and high throughput...
August 1, 2017: Sensors
Yuchao Chang, Hongying Tang, Yongbo Cheng, Qin Zhao, Baoqing Li andXiaobing Yuan
Routing protocols based on topology control are significantly important for improving network longevity in wireless sensor networks (WSNs). Traditionally, some WSN routing protocols distribute uneven network traffic load to sensor nodes, which is not optimal for improving network longevity. Differently to conventional WSN routing protocols, we propose a dynamic hierarchical protocol based on combinatorial optimization (DHCO) to balance energy consumption of sensor nodes and to improve WSN longevity. For each sensor node, the DHCO algorithm obtains the optimal route by establishing a feasible routing set instead of selecting the cluster head or the next hop node...
July 19, 2017: Sensors
Zhigang Jin, Yingying Ma, Yishan Su, Shuo Li, Xiaomei Fu
Underwater sensor networks (UWSNs) have become a hot research topic because of their various aquatic applications. As the underwater sensor nodes are powered by built-in batteries which are difficult to replace, extending the network lifetime is a most urgent need. Due to the low and variable transmission speed of sound, the design of reliable routing algorithms for UWSNs is challenging. In this paper, we propose a Q-learning based delay-aware routing (QDAR) algorithm to extend the lifetime of underwater sensor networks...
July 19, 2017: Sensors
Alexander L Samgin, Alexander N Ezin
In a recent paper in this journal, proton transport in oxides was considered in terms of density functional theory and the non-adiabatic Flynn-Stoneham approach of small polaron type proposed much earlier for metals. Also, regimes of hydrogen diffusion relevant to oxides were reviewed, but the straightforwardly observable channel of low-temperature over-barrier jumps has passed unnoticed. We offer this latter possibility, together with some additional arguments, to make our objection more compelling. There are two major contentious findings in the article...
August 9, 2017: Physical Chemistry Chemical Physics: PCCP
Bernard R Matis, Nelson Y Garces, Erin R Cleveland, Brian H Houston, Jeffrey W Baldwin
The exact nature of the interface between a two-dimensional crystal and its environment can have a significant impact on the electronic transport within the crystal, and can place fundamental limitations on transistor performance and long-term functionality. Two-dimensional transition-metal dichalcogenides are a new class of transistor channel material with electronic properties that can be tailored through dielectric engineering of the material/environmental interface. Here, we report electrical transport measurements carried out in the insulating regime of bilayer molybdenum disulfide, which has been encapsulated within a high-κ hafnium oxide dielectric...
August 10, 2017: ACS Applied Materials & Interfaces
Yong-Hao Pua, Jia-Ying Ho, Suelyn Ai-Sim Chan, Shin-Jiun Khoo, Hwei-Chi Chong
BACKGROUND: Although isokinetic dynamometry often serves as a reference to assess the concurrent validity of weight-machine isotonic strength testing, it is unknown whether isokinetic knee strength is associated with knee function and activity level more strongly than isotonic knee strength in patients with an anterior cruciate ligament reconstruction (ACLR). This study aimed to compare the associations of isokinetic and isotonic knee strength with knee function and work-and-sports activity levels in patients with ACLR...
July 21, 2017: Knee
Felipe Costa Alvim, Paulo Roberto Garcia Lucareli, Luciano Luporini Menegaldo
Functional biomechanical tests allow the assessment of musculoskeletal system impairments in a simple way. Muscle force synergies associated with movement can provide additional information for diagnosis. However, such forces cannot be directly measured noninvasively. This study aims to estimate muscle activations and forces exerted during the preparation phase of the single leg triple hop test. Two different approaches were tested: static optimization (SO) and computed muscle control (CMC). As an indirect validation, model-estimated muscle activations were compared with surface electromyography (EMG) of selected hip and thigh muscles...
July 15, 2017: Gait & Posture
Minoru Kawamura, Ryutaro Yoshimi, Atsushi Tsukazaki, Kei S Takahashi, Masashi Kawasaki, Yoshinori Tokura
The instability of the quantum anomalous Hall (QAH) effect has been studied as a function of the electric current and temperature in ferromagnetic topological insulator thin films. We find that a characteristic current for the breakdown of the QAH effect is roughly proportional to the Hall-bar width, indicating that the Hall electric field is relevant to the breakdown. We also find that electron transport is dominated by variable range hopping (VRH) at low temperatures. Combining the current and temperature dependences of the conductivity in the VRH regime, the localization length of the QAH state is evaluated to be about 5  μm...
July 7, 2017: Physical Review Letters
Norman R Saunders, Katarzyna M Dziegielewska, Sophie C Whish, Lyn A Hinds, Benjamin J Wheaton, Yifan Huang, Steve Henry, Mark D Habgood
Background: Most animal studies of spinal cord injury are conducted in quadrupeds, usually rodents. It is unclear to what extent functional results from such studies can be translated to bipedal species such as humans because bipedal and quadrupedal locomotion involve very different patterns of spinal control of muscle coordination. Bipedalism requires upright trunk stability and coordinated postural muscle control; it has been suggested that peripheral sensory input is less important in humans than quadrupeds for recovery of locomotion following spinal injury...
2017: F1000Research
Hongki Song, Amy Orr, Mengtong Duan, Alexey J Merz, William Wickner
At physiological protein levels, the slow HOPS- and SNARE-dependent fusion which occurs upon complete SNARE zippering is stimulated by Sec17 and Sec18:ATP without requiring ATP hydrolysis. To stimulate, Sec17 needs its central residues which bind the 0-layer of the SNARE complex and its N-terminal apolar loop. Adding a transmembrane anchor to the N-terminus of Sec17 bypasses this requirement for apolarity of the Sec17 loop, suggesting that the loop functions for membrane binding rather than to trigger bilayer rearrangement...
July 18, 2017: ELife
Kate E Webster, Julian A Feller
BACKGROUND: There is some evidence that functional performance and validated outcome scores differ according to the gender, age, and sport participation status of a patient after anterior cruciate ligament (ACL) reconstruction. However, the impact of these three factors, and interaction among them, has not been studied across a large relatively homogeneous group of patients to better elucidate their impact. QUESTIONS/PURPOSES: We reviewed a large cohort of patients who had undergone ACL reconstruction to determine if ROM, knee laxity, objective performance measures, and validated outcome scores differed according to (1) gender; (2) age; and (3) sport participation status...
July 17, 2017: Clinical Orthopaedics and related Research
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