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https://www.readbyqxmd.com/read/28437479/conformational-dynamics-of-bacterial-trigger-factor-in-apo-and-ribosome-bound-states
#1
Mehmet Tarik Can, Zeynep Kurkcuoglu, Gokce Ezeroglu, Arzu Uyar, Ozge Kurkcuoglu, Pemra Doruker
The chaperone trigger factor (TF) binds to the ribosome exit tunnel and helps cotranslational folding of nascent chains (NC) in bacterial cells and chloroplasts. In this study, we aim to investigate the functional dynamics of fully-atomistic apo TF and its complex with 50S. As TF accomodates a high percentage of charged residues on its surface, the effect of ionic strength on TF dynamics is assessed here by performing five independent molecular dynamics (MD) simulations (total of 1.3 micro-second duration) at 29 mM and 150 mM ionic strengths...
2017: PloS One
https://www.readbyqxmd.com/read/28437116/pump-power-dependence-of-coherent-acoustic-phonon-frequencies-in-colloidal-cdse-cds-core-shell-nanoplatelets
#2
Dong Shuo, Jie Lian, Mark H Jhon, Yinthai Chan, Zhi-Heng Loh
Femtosecond optical pump-probe spectroscopy resolves hitherto unobserved coherent acoustic phonons in colloidal CdSe/CdS core/shell nanoplatelets (NPLs). With increasing pump fluence, the frequency of the in-plane acoustic mode increases from 5.2 to 10.7 cm(-1), whereas the frequency of the out-of-plane mode remains at ~20 cm(-1). Analysis of the oscillation phases suggests that the coherent acoustic phonon generation mechanism transitions from displacive excitation to sub-picosecond Auger hole trapping with increasing pump fluence...
April 24, 2017: Nano Letters
https://www.readbyqxmd.com/read/28436583/physical-activity-and-exercise-for-chronic-pain-in-adults-an-overview-of-cochrane-reviews
#3
REVIEW
Louise J Geneen, R Andrew Moore, Clare Clarke, Denis Martin, Lesley A Colvin, Blair H Smith
BACKGROUND: Chronic pain is defined as pain lasting beyond normal tissue healing time, generally taken to be 12 weeks. It contributes to disability, anxiety, depression, sleep disturbances, poor quality of life, and healthcare costs. Chronic pain has a weighted mean prevalence in adults of 20%.For many years, the treatment choice for chronic pain included recommendations for rest and inactivity. However, exercise may have specific benefits in reducing the severity of chronic pain, as well as more general benefits associated with improved overall physical and mental health, and physical functioning...
April 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28435943/influence-of-charged-defects-on-the-interfacial-bonding-strength-of-tantalum-and-silver-doped-nanograined-tio2
#4
Jalal Azadmanjiri, James Wang, Christopher C Berndt, Ajay Kapoor, De Ming Zhu, Andrew S M Ang, Vijay K Srivastava
A nano-grained layer including line defects was formed on the surface of a Ti alloy (Tialloy, Ti-6Al-4V ELI). Then, the micro- and nano-grained Tialloy with the formation of TiO2 on its top surface was coated with a bioactive Ta layer with or without incorporating an antibacterial agent of Ag that was manufactured by magnetron sputtering. Subsequently, the influence of the charged defects (the defects that can be electrically charged on the surface) on the interfacial bonding strength and hardness of the surface system was studied via an electronic model...
April 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28434464/development-of-a-falls-reduction-yoga-program-for-older-adults-a-pilot-study
#5
Paul D Smith, Paul Mross, Nate Christopher
OBJECTIVES: Work with local rural organizations to develop an evidence-based hatha yoga program intended to improve core strength and balance to reduce falls risk. Feasibility determined by successful recruiting, intervention and evaluation of participants and acceptable frequency of adverse events. DESIGN: Single-arm pilot study. SETTING: Rural Wisconsin town of 4200 people. INTERVENTION: Eight week yoga program with weekly group classes and home yoga practice three times per week...
April 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28434092/cyberbullying-victimization-and-adolescent-mental-health-evidence-of-differential-effects-by-sex-and-mental-health-problem-type
#6
Soyeon Kim, Scott R Colwell, Anna Kata, Michael H Boyle, Katholiki Georgiades
The use of electronic communication technologies has become a core method for adolescent communication. While there are many benefits to such technologies, cyberbullying has emerged as a potential harm. This study examines the association between cyberbullying and adolescent mental health problems and the extent to which this association differs by sex and mental health problem type. A clustered sample of 31,148 students in grades 6-12 (Female = 51.9%; 56.5% Caucasian, 10.2% South Asian) completed an anonymous survey asking their frequency of exposure to traditional forms of bullying, cyberbullying, and experiences of mental health problems over the past 6 months...
April 22, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28432739/effect-of-a-4-week-elastic-resistance-band-training-regimen-on-back-kinematics-in-horses-trotting-in-hand-and-on-the-lunge
#7
T Pfau, V Simons, N Rombach, N Stubbs, R Weller
REASONS FOR PERFORMING STUDY: Training and rehabilitation techniques aiming at improving core muscle strength may result in increased dynamic stability of the equine vertebral column. A system of elastic resistance bands is suggested to provide proprioceptive feedback during motion to encourage recruitment of core abdominal and hindquarter musculature for improved dynamic stability. OBJECTIVES: To quantify the effects of a specific resistance band system on back kinematics during trot in-hand and during lungeing at beginning and end of a 4-week exercise programme...
April 22, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28428829/semivariogram-analysis-of-bone-images-implemented-on-fpga-architectures
#8
Mukul Shirvaikar, Yamuna Lagadapati, Xuanliang Dong
Osteoporotic fractures are a major concern for the healthcare of elderly and female populations. Early diagnosis of patients with a high risk of osteoporotic fractures can be enhanced by introducing second-order statistical analysis of bone image data using techniques such as variogram analysis. Such analysis is computationally intensive thereby creating an impediment for introduction into imaging machines found in common clinical settings. This paper investigates the fast implementation of the semivariogram algorithm, which has been proven to be effective in modeling bone strength, and should be of interest to readers in the areas of computer-aided diagnosis and quantitative image analysis...
March 2017: J Real Time Image Process
https://www.readbyqxmd.com/read/28424292/loss-and-recovery-of-functional-connectivity-in-cultured-cortical-networks-exposed-to-hypoxia
#9
Joost le Feber, Niels Erkamp, Michel J A M van Putten, Jeannette Hofmeijer
In the core of a brain infarct, loss of neuronal function is followed by neuronal death within minutes. In an area surrounding the core (penumbra), some perfusion remains. Here, neurons initially remain structurally intact, but massive synaptic failure strongly reduces neural activity. Activity in the penumbra may eventually recover or further deteriorate towards massive cell death. Besides activity recovery, return of brain functioning requires restoration of connectivity. However, low activity has been shown to initiate compensatory mechanisms that affect network connectivity...
April 19, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28423932/comparing-biomechanical-properties-repair-times-and-value-of-common-core-flexor-tendon-repairs
#10
Aakash Chauhan, Patrick Schimoler, Mark C Miller, Alexander Kharlamov, Gregory A Merrell, Bradley A Palmer
BACKGROUND: The aim of the study was to compare biomechanical strength, repair times, and repair values for zone II core flexor tendon repairs. METHODS: A total of 75 fresh-frozen human cadaveric flexor tendons were harvested from the index through small finger and randomized into one of 5 repair groups: 4-stranded cross-stitch cruciate (4-0 polyester and 4-0 braided suture), 4-stranded double Pennington (2-0 knotless barbed suture), 4-stranded Pennington (4-0 double-stranded braided suture), and 6-stranded modified Lim-Tsai (4-0 looped braided suture)...
April 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28422813/a-new-approach-in-assessing-core-muscle-endurance-using-ratings-of-perceived-exertion
#11
James D George, Jeffrey R Tolley, Pat R Vehrs, Joel D Reece, M Fatih Akay, Edward D J Cambridge
This study sought to develop regression models to estimate maximal endurance time by using data from four core muscle endurance tests. Eighty healthy university students (age: 22.7 ± 1.9 yr) performed the plank, right side-bridge, left side-bridge, and back extension tests in a random order. Participants were instructed to hold each static position for a maximal endurance time, while maintaining proper form, and then rest for 5 min between tests. A test administrator recorded participants' ratings of perceived exertion (RPE; modified 10-point scale) every 5 s...
April 4, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28422241/super-tough-ultra-stretchable-and-strongly-compressive-hydrogels-with-core-shell-latex-particles-inducing-efficient-aggregation-of-hydrophobic-chains
#12
Xiuyan Ren, Chang Huang, Lijie Duan, Baijun Liu, Lvjun Bu, Shuang Guan, Jiliang Hou, Huixuan Zhang, Guanghui Gao
Toughness, strechability and compressibility for hydrogels were ordinarily balanced for their use as mechanically responsive materials. For example, macromolecular microsphere composite hydrogels with chemical crosslinking exhibited excellent compression strength and strechability, but poor tensile stress. Here, a novel strategy for the preparation of a super-tough, ultra-stretchable and strongly compressive hydrogel was proposed by introducing core-shell latex particles (LPs) as crosslinking centers for inducing efficient aggregation of hydrophobic chains...
April 19, 2017: Soft Matter
https://www.readbyqxmd.com/read/28422208/encapsulation-into-complex-coacervate-core-micelles-promotes-egfp-dimerization
#13
A Nolles, N J E van Dongen, A H Westphal, A J W G Visser, J M Kleijn, W J H van Berkel, J W Borst
Complex coacervate core micelles (C3Ms) are colloidal structures useful for encapsulation of biomacromolecules. We previously demonstrated that enhanced green fluorescent protein (EGFP) can be encapsulated into C3Ms using the diblock copolymer poly(2-methyl-vinyl-pyridinium)41-b-poly(ethylene-oxide)205. This packaging resulted in deviating spectroscopic features of the encapsulated EGFP molecules. Here we show that for monomeric EGFP variant (mEGFP) micellar encapsulation affects the absorption and fluorescence properties to a much lesser extent, and that changes in circular dichroism characteristics are specific for encapsulated EGFP...
April 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28420829/bonding-measurement-strength-and-fracture-mechanics-approaches
#14
Chuchai Anunmana, Wiroj Wansom
This study investigated the effect of cross-sectional areas on interfacial fracture toughness and bond strength of bilayered dental ceramics. Zirconia core ceramics were veneered and cut to produce specimens with three different cross-sectional areas. Additionally, monolithic specimens of glass veneer were also prepared. The specimens were tested in tension until fracture at the interface and reported as bond strength. Fracture surfaces were observed, and the apparent interfacial toughness was determined from critical crack size and failure stress...
April 18, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28416470/block-ionomer-micellar-nanoparticles-from-double-hydrophilic-copolymers-classifications-and-promises-for-delivery-of-cancer-chemotherapeutics
#15
REVIEW
S S Abolmaali, A M Tamaddon, M Salmanpour, S Mohammadi, R Dinarvand
A class of double hydrophilic copolymers comprising ionic and nonionic water-soluble blocks, which are also called block ionomers, represent an interesting type of polymer assembly forming stable, homogeneous core-corona dispersions. They exhibit the solution behavior of normal polyelectrolytes, whereas assembly into micelle, vesicle or disk morphology happens by an external stimulus (pH, temperature or ionic strength) or complex formation with metal ions, ionic surfactants, polyelectrolytes, etc. Temperature, pH, redox or salt sensitivity affords a unique opportunity to control the triggered release of payloads accommodated through electrostatic interaction, coordination or chemical conjugation...
April 14, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28416451/diffeomorphic-functional-brain-surface-alignment-functional-demons
#16
Karl-Heinz Nenning, Hesheng Liu, Satrajit Ghosh, Mert Sabuncu, Ernst Schwartz, Georg Langs
Aligning brain structures across individuals is a central prerequisite for comparative neuroimaging studies. Typically, registration approaches assume a strong association between the features used for alignment, such as macro-anatomy, and the variable observed, such as functional activation or connectivity. Here, we propose to use the structure of intrinsic resting state fMRI signal correlation patterns as a basis for alignment of the cortex in functional studies. Rather than assuming the spatial correspondence of functional structures between subjects, we have identified locations with similar connectivity profiles across subjects...
April 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28412887/preventing-and-de-escalating-aggressive-behavior-among-adult-psychiatric-patients-a-systematic-review-of-the-evidence
#17
Bradley N Gaynes, Carrie L Brown, Linda J Lux, Kimberly A Brownley, Richard A Van Dorn, Mark J Edlund, Emmanuel Coker-Schwimmer, Rachel Palmieri Weber, Brian Sheitman, Theodore Zarzar, Meera Viswanathan, Kathleen N Lohr
OBJECTIVE: The project goal was to compare the effectiveness of strategies to prevent and de-escalate aggressive behaviors among psychiatric patients in acute care settings, including interventions for reducing use of seclusion and restraint. METHODS: Relevant databases were systematically reviewed for comparative studies of violence prevention and de-escalation strategies involving adult psychiatric patients in acute care settings. Studies (trials and cohort studies) were required to report on aggression or seclusion or restraint outcomes...
April 17, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28407380/n-glycan-maturation-mutants-in-lotus-japonicus-for-basic-and-applied-glycoprotein-research
#18
Carina T Pedersen, Ian Loke, Andrea Lorentzen, Sara Wolf, Manoj Kamble, Sebastian K Kristensen, David Munch, Simona Radutoiu, Edzard Spillner, Peter Roepstorff, Morten Thaysen-Andersen, Jens Stougaard, Svend Dam
Studies of protein N-glycosylation are important for answering fundamental questions on the diverse functions of glycoproteins in plant growth and development. Here we generated and characterised a comprehensive collection of Lotus japonicus LORE1 insertion mutants, each lacking the activity of one of the twelve enzymes required for normal N-glycan maturation in the glycosylation machinery. The inactivation of the individual genes resulted in altered N-glycan patterns as documented using mass spectrometry and glycan-recognising antibodies, indicating successful identification of null-mutations in the target glyco-genes...
April 13, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28406900/gene-co-expression-network-connectivity-is-an-important-determinant-of-selective-constraint
#19
Niklas Mähler, Jing Wang, Barbara K Terebieniec, Pär K Ingvarsson, Nathaniel R Street, Torgeir R Hvidsten
While several studies have investigated general properties of the genetic architecture of natural variation in gene expression, few of these have considered natural, outbreeding populations. In parallel, systems biology has established that a general feature of biological networks is that they are scale-free, rendering them buffered against random mutations. To date, few studies have attempted to examine the relationship between the selective processes acting to maintain natural variation of gene expression and the associated co-expression network structure...
April 13, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28402737/comparison-of-polymerization-shrinkage-physical-properties-and-marginal-adaptation-of-flowable-and-restorative-bulk-fill-resin-based-composites
#20
J H Jung, S H Park
PURPOSE: The purpose of this study was to compare the marginal adaptation of two flowable bulk fill resin-based composites (FB-RBCs), two restorative bulk fill resin-based composites (RB-RBCs), and one regular incremental-fill RBC in MOD cavities in vitro. Additionally, the influence of linear polymerization shrinkage, shrinkage force, flexural modulus, and bottom/top surface hardness ratio on the marginal adaptation was evaluated. METHODS: A Class II MOD cavity was prepared in 40 extracted sound lower molars...
April 12, 2017: Operative Dentistry
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