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https://www.readbyqxmd.com/read/28640810/lassim-a-network-inference-toolbox-for-genome-wide-mechanistic-modeling
#1
Rasmus Magnusson, Guido Pio Mariotti, Mattias Köpsén, William Lövfors, Danuta R Gawel, Rebecka Jörnsten, Jörg Linde, Torbjörn Nordling, Elin Nyman, Sylvie Schulze, Colm E Nestor, Huan Zhang, Gunnar Cedersund, Mikael Benson, Andreas Tjärnberg, Mika Gustafsson
Recent technological advancements have made time-resolved, quantitative, multi-omics data available for many model systems, which could be integrated for systems pharmacokinetic use. Here, we present large-scale simulation modeling (LASSIM), which is a novel mathematical tool for performing large-scale inference using mechanistically defined ordinary differential equations (ODE) for gene regulatory networks (GRNs). LASSIM integrates structural knowledge about regulatory interactions and non-linear equations with multiple steady state and dynamic response expression datasets...
June 22, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28638482/implantable-and-biodegradable-macroporous-iron-oxide-frameworks-for-efficient-regeneration-and-repair-of-infracted-heart
#2
Wenshuo Wang, Hongyue Tao, Yun Zhao, Xiaotian Sun, Jing Tang, Cordelia Selomulya, Jia Tang, Tianchan Chen, Yang Wang, Minglei Shu, Lei Wei, Guanyu Yi, Jixue Zhou, Lai Wei, Chunsheng Wang, Biao Kong
The construction, characterization and surgical application of a multilayered iron oxide-based macroporous composite framework were reported in this study. The framework consisted of a highly porous iron oxide core, a gelatin-based hydrogel intermediary layer and a matrigel outer cover, which conferred a multitude of desirable properties including excellent biocompatibility, improved mechanical strength and controlled biodegradability. The large pore sizes and high extent of pore interconnectivity of the framework stimulated robust neovascularization and resulted in substantially better cell viability and proliferation as a result of improved transport efficiency for oxygen and nutrients...
2017: Theranostics
https://www.readbyqxmd.com/read/28629044/recovery-evaluation-of-rats-damaged-tibias-implantation-of-core-shell-structured-bone-scaffolds-made-using-hollow-braids-and-a-freeze-thawing-process
#3
Jia-Horng Lin, Mong-Chuan Lee, Chih-Kuang Chen, Chien-Lin Huang, Yueh-Sheng Chen, Shih-Peng Wen, Shu-Ting Kuo, Ching-Wen Lou
This study prepares biodegradable bone scaffolds helping the recovery of damaged tibias of rats. Polyvinyl alcohol (PVA) plied yarns are fabricated into hollow braids. The braids are combined with hydroxyapatite (HA)/gelatin/PVA mixtures and processed using freeze-thawing and freeze-drying processes in order to form bone scaffolds. These bone scaffolds are observed by scanning electron scope (SEM) and tested for compression strength. Afterwards, recovery of damaged bone, the morphology of the bone, and the histological observation are evaluated...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28627415/examination-to-assess-the-clinical-exam-and-documentation-of-spine-pathology-among-orthopaedic-residents
#4
Jack M Haglin, John L Zeller, Kenneth A Egol, Donna P Phillips
BACKGROUND: The Accreditation Council of Graduate Medical Education (ACGME) guidelines require residency programs to teach and evaluate residents in six overarching "core competencies" and document progress through educational milestones. In order to assess the progress of orthopaedic interns' skills in performing a history, physical exam, and documentation of the encounter for a standardized patient with spinal stenosis, a Structured Objective Clinical Examination (OSCE) was conducted for 13 orthopaedic intern residents, following a one month boot camp that included communications skills and curriculum in history and physical examination...
June 13, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28626927/carbon-nanotube-multilayered-graphene-edge-plane-core-shell-hybrid-foams-for-ultrahigh-performance-electromagnetic-interference-shielding
#5
Qiang Song, Fang Ye, Xiaowei Yin, Wei Li, Hejun Li, Yongsheng Liu, Kezhi Li, Keyu Xie, Xuanhua Li, Qiangang Fu, Laifeng Cheng, Litong Zhang, Bingqing Wei
Materials with an ultralow density and ultrahigh electromagnetic-interference (EMI)-shielding performance are highly desirable in fields of aerospace, portable electronics, and so on. Theoretical work predicts that 3D carbon nanotube (CNT)/graphene hybrids are one of the most promising lightweight EMI shielding materials, owing to their unique nanostructures and extraordinary electronic properties. Herein, for the first time, a lightweight, flexible, and conductive CNT-multilayered graphene edge plane (MLGEP) core-shell hybrid foam is fabricated using chemical vapor deposition...
June 19, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28625517/reduced-tdp-43-expression-improves-neuronal-activities-in-a-drosophila-model-of-perry-syndrome
#6
Yuka Hosaka, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Changxu Cui, Taku Arano, Yuzuru Imai, Nobutaka Hattori
Parkinsonian Perry syndrome, involving mutations in the dynein motor component dynactin or p150(Glued), is characterized by TDP-43 pathology in affected brain regions, including the substantia nigra. However, the molecular relationship between p150(Glued) and TDP-43 is largely unknown. Here, we report that a reduction in TDP-43 protein levels alleviates the synaptic defects of neurons expressing the Perry mutant p150(G50R) in Drosophila. Dopaminergic expression of p150(G50R), which decreases dopamine release, disrupts motor ability and reduces the lifespan of Drosophila...
June 8, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28624185/the-formation-of-nanoparticles-between-small-interfering-rna-and-amphipathic-cell-penetrating-peptides
#7
Ly Pärnaste, Piret Arukuusk, Kent Langel, Tanel Tenson, Ülo Langel
Cell-penetrating peptides (CPPs) are delivery vectors widely used to aid the transport of biologically active cargoes to intracellular targets. These cargoes include small interfering RNAs (siRNA) that are not naturally internalized by cells. Elucidating the complexities behind the formation of CPP and cargo complexes is crucial for understanding the processes related to their delivery. In this study, we used modified analogs of the CPP transportan10 and investigated the binding properties of these CPPs to siRNA, the formation parameters of the CPP/siRNA complexes, and their stabiliy to enzymatic degradation...
June 16, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28620575/osteoporosis-management-in-ankylosing-spondylitis
#8
Alicia M Hinze, Grant H Louie
Low bone mineral density (BMD) is increasingly recognized as a common comorbid condition in ankylosing spondylitis (AS). As low BMD increases fracture risk, it is important to identify and treat low BMD in patients with AS who have been shown to be at increased risk for fractures above the population normal. Since low BMD occurs early in disease, we screen during the first year of diagnosis with dual energy x-ray absorptiometry (DXA). If patients are found to have osteoporosis by T-score of less than -2.5 or if their Z-score on DXA is more than two standard deviations below the mean, we initiate therapy with bisphosphonates in males and in females who are not planning any future pregnancies...
December 2016: Current Treatment Options in Rheumatology
https://www.readbyqxmd.com/read/28618613/describing-magnetorheology-under-a-colloidal-glass-approach
#9
J P Segovia-Gutiérrez, J de Vicente, Antonio M Puertas, R Hidalgo-Alvarez
The equilibrium structure and dynamics of magnetorheological (MR) fluids are studied in this work by simulations, where particles are modeled as dipoles with a quasihard spherical core. Upon increasing the interaction strength, controlled experimentally by the magnetic field, elongated clusters grow and, for intense fields, thick columns form, aligned with the field. The dynamics of the system is monitored by the mean-squared displacement and density correlation functions, which show an increasing slowing down with the attraction strength...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28612865/esipt-and-fret-probes-for-monitoring-nanoparticle-polymer-coating-stability
#10
Julio C Azcárate, Sebastián A Díaz, Jonathan A Fauerbach, Florencia Gillanders, Aldo A Rubert, Elizabeth A Jares-Erijman, Thomas M Jovin, Mariano H Fonticelli
Coating strategies of inorganic nanoparticles (NPs) can provide properties unavailable to the NP core alone, such as targeting, specific sensing, and increased biocompatibility. Non-covalent amphiphilic NP capping polymers function via hydrophobic interactions with surface ligands and are extensively used to transfer NPs to aqueous media. For applications of coated NPs as actuators (sensors, markers, or for drug delivery) in a complex environment, such as biological systems, it is important to achieve a deep understanding of the factors affecting coating stability and behavior...
June 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/28607195/hydrogen-in-ti-and-zr-alloys-industrial-perspective-failure-modes-and-mechanistic-understanding
#11
REVIEW
T P Chapman, D Dye, D Rugg
Titanium is widely used in demanding applications, such as in aerospace. Its strength-to-weight ratio and corrosion resistance make it well suited to highly stressed rotating components. Zirconium has a no less critical application where its low neutron capture cross section and good corrosion resistance in hot water and steam make it well suited to reactor core use, including fuel cladding and structures. The similar metallurgical behaviour of these alloy systems makes it alluring to compare and contrast their behaviour...
July 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28606191/no-calm-after-the-storm-a-systematic-review-of-human-health-following-flood-and-storm-disasters
#12
Dell D Saulnier, Kim Brolin Ribacke, Johan von Schreeb
Introduction How the burden of disease varies during different phases after floods and after storms is essential in order to guide a medical response, but it has not been well-described. The objective of this review was to elucidate the health problems following flood and storm disasters. METHODS: A literature search of the databases Medline (US National Library of Medicine, National Institutes of Health; Bethesda, Maryland USA); Cinahl (EBSCO Information Services; Ipswich, Massachusetts USA); Global Health (EBSCO Information Services; Ipswich, Massachusetts USA); Web of Science Core Collection (Thomson Reuters; New York, New York USA); Embase (Elsevier; Amsterdam, Netherlands); and PubMed (National Center for Biotechnology Information, National Institutes of Health; Bethesda, Maryland USA) was conducted in June 2015 for English-language research articles on morbidity or mortality and flood or storm disasters...
June 13, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28605972/resting-state-connectivity-between-default-mode-network-and-insula-encodes-acute-migraine-headache
#13
Gianluca Coppola, Antonio Di Renzo, Emanuele Tinelli, Cherubino Di Lorenzo, Marco Scapeccia, Vincenzo Parisi, Mariano Serrao, Maurizio Evangelista, Anna Ambrosini, Claudio Colonnese, Jean Schoenen, Francesco Pierelli
Background Previous functional MRI studies have revealed that ongoing clinical pain in different chronic pain syndromes is directly correlated to the connectivity strength of the resting default mode network (DMN) with the insula. Here, we investigated seed-based resting state DMN-insula connectivity during acute migraine headaches. Methods Thirteen migraine without aura patients (MI) underwent 3 T MRI scans during the initial six hours of a spontaneous migraine attack, and were compared to a group of 19 healthy volunteers (HV)...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28602186/two-phase-hollow-fiber-liquid-microextraction-based-on-reverse-micelle-for-the-determination-of-quercetin-in-human-plasma-and-vegetables-samples
#14
Samereh Ranjbar Banforuzi, Mohammad Reza Hadjmohammadi
A new two-phase hollow fiber-liquid microextraction based on reverse micelle as sensitive and efficient method for the extraction of quercetin in human plasma, onion and tomato samples was developed for the first time. The extraction is based on the solubilization of analyte in the aqueous core of the reverse micelle of cationic cethyltrimethyl ammonium bromide surfactant, CTAB, which are present in the organic phase and are used as acceptor phase in hollow fiber-liquid phase microextraction. Experimental results show that the electrostatic interaction between the oppositely charged surfactant head group present in the reverse micelles and the analyte molecule has a key role in the extraction...
October 1, 2017: Talanta
https://www.readbyqxmd.com/read/28602076/rapid-generation-of-universal-synthetic-promoters-for-controlled-gene-expression-in-both-gas-fermenting-and-saccharolytic-clostridium-species
#15
Gaohua Yang, Dechen Jia, Lin Jin, Yuqian Jiang, Yong Wang, Weihong Jiang, Yang Gu
Engineering solventogenic clostridia, a group of important industrial microorganisms, to realize their full potential in biorefinery application is still hindered by the absence of plentiful biological parts. Here, we developed an effective approach for rapid generation of a synthetic promoter library in solventogenic clostridia based on a dual-reporter system (catP-lacZ) and a widely used strong thl promoter. The yielded artificial promoters, spanning 2 orders of magnitude, comprised two modular components (the core promoter region and the spacer between RBS and the translation-initiating code), and the strongest promoter had an over 10-fold-higher activity than the original expression part Pthl...
June 16, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28602017/design-and-evaluation-of-artificial-cornea-with-core-skirt-design-using-polyhydroxyethyl-methacrylate-and-graphite
#16
Mukty Sinha, Tanvi Gupte
PURPOSE: Artificial cornea is the effective treatment option for corneal blindness. One of the challenges with the artificial cornea is limited, or no tissue integration necessitates reimplantation due to necrosis or corneal melting. We propose here a new formulation approach for core-skirt incorporating graphite in the outer skirt region to improve cell adhesion. METHODS: Hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate were procured from Sigma-Aldrich...
June 10, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28597006/effect-of-final-irrigation-protocol-and-etching-mode-on-bond-strength-of-a-multimode-adhesive-in-the-root-canal
#17
Kerstin Bitter, Luise Polster, Haitham Askar, Manja von Stein-Lausnitz, Guido Sterzenbach
PURPOSE: To analyze the effects of ethanol for final post space irrigation and etching mode on the bond strength of fiber posts luted with a mild multimode adhesive (pH 2.3) as compared with a reference group using a self-adhesive resin cement (SAR). MATERIALS AND METHODS: Human anterior teeth were endodontically treated. After post space preparation, the root canals were irrigated using 1% sodium hypochlorite (NaOCl) applied with passive ultrasonic irrigation, followed by either distilled water (control) or distilled water and ethanol 99% as final post space irrigation...
June 8, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/28592971/formulation-development-of-high-strength-gel-system-and-evaluation-on-profile-control-performance-for-high-salinity-and-low-permeability-fractured-reservoir
#18
Chengli Zhang, Guodong Qu, Guoliang Song
For the large pores and cracks of reservoirs with low temperatures, high salinity, and low permeability, a new type of high strength gel ABP system is developed in this paper. The defects of conventional gels such as weak gel strength, no gelling, and easy dehydration are overcome under the conditions of low temperature and high salinity. The temperature and salt resistance, plugging characteristics, and EOR of the gel system are studied. Under the condition of 32°C and 29500 mg/L salinity, the ABP system formulation is for 0...
2017: International Journal of Analytical Chemistry
https://www.readbyqxmd.com/read/28592794/the-dynamic-functional-core-network-of-the-human-brain-at-rest
#19
A Kabbara, W El Falou, M Khalil, F Wendling, M Hassan
The human brain is an inherently complex and dynamic system. Even at rest, functional brain networks dynamically reconfigure in a well-organized way to warrant an efficient communication between brain regions. However, a precise characterization of this reconfiguration at very fast time-scale (hundreds of millisecond) during rest remains elusive. In this study, we used dense electroencephalography data recorded during task-free paradigm to track the fast temporal dynamics of spontaneous brain networks. Results obtained from network-based analysis methods revealed the existence of a functional dynamic core network formed of a set of key brain regions that ensure segregation and integration functions...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28590738/tyrosine-as-a-non-perturbing-site-specific-vibrational-reporter-for-protein-dynamics
#20
Farzaneh Chalyavi, David G Hogle, Matthew J Tucker
The ability to detect changes in the local environment of proteins is pivotal to determining their dynamic nature during many biological processes. For this purpose, the utility of the tyrosine ring breathing vibration as a sensitive infrared reporter for measuring the local electric field in protein is investigated. Variations in the bandwidth of this vibrational transition in a variety of solvents indicate differences in microenvironment affect the inhomogeneous broadening and thus the frequency distribution...
June 7, 2017: Journal of Physical Chemistry. B
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