keyword
https://read.qxmd.com/read/38527522/acute-kidney-injury-in-patients-with-cirrhosis-acute-disease-quality-initiative-adqi-and-international-club-of-ascites-ica-joint-multidisciplinary-consensus-meeting
#1
REVIEW
Mitra K Nadim, John A Kellum, Lui Forni, Claire Francoz, Sumeet K Asrani, Marlies Ostermann, Andrew S Allegretti, Javier A Neyra, Jody C Olson, Salvatore Piano, Lisa B VanWagner, Elizabeth C Verna, Ayse Akcan-Arikan, Paolo Angeli, Justin M Belcher, Scott W Biggins, Akash Deep, Guadalupe Garcia-Tsao, Yuri S Genyk, Pere Gines, Patrick S Kamath, Sandra L Kane-Gill, Manish Kaushik, Nuttha Lumlertgul, Etienne Macedo, Rakhi Maiwall, Sebastian Marciano, Raimund H Pichler, Claudio Ronco, Puneeta Tandon, Juan-Carlos Q Velez, Ravindra L Mehta, François Durand
Patients with cirrhosis are prone to develop acute kidney injury (AKI), a complication associated with a markedly increased in-hospital morbidity and mortality, along with a risk of progression to chronic kidney disease. Whereas patients with cirrhosis are at increased risk of developing any phenotype of AKI, hepatorenal syndrome (HRS), a specific form of AKI (HRS-AKI) in patients with advanced cirrhosis and ascites, carries an especially high mortality risk. Early recognition of HRS-AKI is crucial since administration of splanchnic vasoconstrictors may reverse the AKI and serve as a bridge to liver transplantation, the only curative option...
March 23, 2024: Journal of Hepatology
https://read.qxmd.com/read/38526023/review-article-recent-advances-in-ascites-and-acute-kidney-injury-management-in-cirrhosis
#2
REVIEW
Danielle Adebayo, Florence Wong
BACKGROUND: Better understanding of disease pathophysiology has led to advances in managing ascites and its associated complications including hepatorenal syndrome-acute kidney Injury (HRS-AKI), especially medicinal and interventional advances. AIM: To review the latest changes in the management of ascites and HRS-AKI. METHODS: A literature search was conducted in Pubmed, using the keywords cirrhosis, ascites, renal dysfunction, acute kidney injury, hepatorenal syndrome, beta-blockers, albumin, TIPS and vasoconstrictors, including only publications in English...
March 25, 2024: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/38501671/assessment-of-the-2021-aasld-practice-guidance-for-albumin-infusion-in-elective-therapeutic-paracentesis-a-regression-discontinuity-design
#3
JOURNAL ARTICLE
Tomohiro Tanaka, Mark Vander Weg, Michael P Jones, George Wehby
BACKGROUND: The 2021 American Association for the Study of Liver Disease (AASLD) Practice Guidance recommends albumin infusion when removing ≥ 5 liters of ascites to prevent post-paracentesis circulatory dysfunction. However, the optimal criteria and scenarios for initiating albumin infusion subsequent to therapeutic paracentesis (TP) have been subject to limited scientific inquiry. METHODS: We conducted a retrospective cohort study at a U.S. academic healthcare center...
March 19, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38490364/modified-radiation-lobectomy-strategy-of-radioembolization-for-right-sided-unresectable-primary-liver-tumors
#4
JOURNAL ARTICLE
Qian Yu, Yating Wang, Ethan Ungchusri, Anjana Pillai, Chih-Yi Liao, John Fung, Diego DiSabato, Talia Baker, Mikin Patel, Thuong Van Ha, Osman Ahmed
PURPOSE: To assess the safety and effectiveness of using modified radiation lobectomy (mRL) to treat primary hepatic tumors located in the right hepatic lobe (segments V-VIII) and determine future liver remnant (FLR) hypertrophy. METHODS: A retrospective review was performed at a single institution to include 19 consecutive patients (7 Female, 12 Male) who underwent single-session mRL for right sided primary hepatic tumors: 15 received segmentectomy plus lobectomy (segmental dose >190 Gy and lobar dose >80 Gy); 4 were treated with the double-segmental approach (dominant segments >190 Gy and non-dominant segments > 80 Gy)...
March 13, 2024: Journal of Vascular and Interventional Radiology: JVIR
https://read.qxmd.com/read/38469015/multi-drug-resistant-tuberculosis-peritonitis-a-case-report
#5
Rhea Verma, Clinton Sonier, Nida Rizvi, Rahul Kashyap
The increasing incidence of tuberculosis raises concerns globally, impacting both developing and developed nations. Abdominal tuberculosis stands out as the most prevalent form of extrapulmonary tuberculosis. This case report details the diagnostic journey of a young male with abdominal TB complicated by concurrent HIV infection. The patient presented with night sweats and substantial weight loss, concurrently receiving a naive human immunodeficiency virus (HIV) diagnosis with an undetectable CD4 count...
February 2024: Curēus
https://read.qxmd.com/read/38463353/correlation-between-serum-markers-and-transjugular-intrahepatic-portosystemic-shunt-prognosis-in-patients-with-cirrhotic-ascites
#6
JOURNAL ARTICLE
Xiao-Gang Hu, Xiao-Xian Yang, Jun Lu, Gang Li, Jian-Ji Dai, Jia-Min Wang, Yi Deng, Rui Feng
BACKGROUND: Individuals with refractory ascites in the context of liver cirrhosis typically face an adverse prognosis. The transjugular intrahepatic portosystemic shunt (TIPS) is an efficacious intervention, but there is a lack of reliable tools for postoperative prognosis assessment. Previously utilized clinical biochemical markers, such as the serum albumin concentration (Alb), sodium (Na+ ) concentration, and serum creatinine (Scr), have limited predictive value. Therefore, the quest for novel, specific biomarkers to evaluate the post-TIPS prognosis in patients with liver cirrhosis and refractory ascites holds significant practical importance...
February 27, 2024: World Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38457551/b-cell-lymphoma-with-cytokine-storm-in-serosal-effusion-a-case-report-and-literature-review
#7
REVIEW
Xiaoli Zhang, Xueze Shi, Xixi Liu, Chencheng Li, Zuqiong Xu, Xingbin Dai, Bangyun Ma, Xuejun Zhu
RATIONALE: Cytokine storm is now considered to be a systemic inflammatory response, but local cytokine storm may exist in systemic diseases of the blood system. Monitoring of regional cytokine storm is an important clue for the diagnosis of systemic diseases. PATIENT CONCERNS: A 72-years-old male presented to our hospital with multiple serosal effusion without solid mass or enlarged lymph nodes. We found that the level of cytokines in ascites was tens to hundreds of times higher than that in plasma, mainly IL-6 and IL-8...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38436322/-a-case-of-neonatal-liver-failure
#8
JOURNAL ARTICLE
Xiao-Xiao Lu, Yi Lu, Lin Yang, Yang-Yang Ma, Huan-Huan Wang
The patient was a male infant, born full-term, admitted to the hospital at 28 days of age due to jaundice for 20 days and abdominal distension for 15 days. The patient developed symptoms of jaundice, hepatosplenomegaly, massive ascites, and progressively worsening liver function leading to liver failure, severe coagulation disorders, and thrombocytopenia one week after birth. Various treatments were administered, including anti-infection therapy, fluid restriction, use of diuretics, use of hepatoprotective and choleretic agents, intermittent paracentesis, blood exchange, and intravenous immunoglobulin, albumin, and plasma transfusions...
February 15, 2024: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://read.qxmd.com/read/38433869/protocol-to-evaluate-the-efficacy-and-safety-of-tolvaptan-in-patients-with-refractory-ascites-after-liver-resection-an-open-label-single-arm-phase-i-ii-study
#9
JOURNAL ARTICLE
Yosuke Namba, Tsuyoshi Kobayashi, Shintaro Kuroda, Masakazu Hashimoto, Daisuke Takei, Sotaro Fukuhara, Ko Oshita, Keiso Matsubara, Naruhiko Honmyo, Ryosuke Nakano, Hiroshi Sakai, Hiroyuki Tahara, Masahiro Ohira, Kentaro Ide, Hideki Ohdan
BACKGROUND: In patients with chronic liver diseases such as cirrhosis, massive ascites after hepatic resection is the cause of prolonged hospitalization and worsening prognosis. Recently, the efficacy of tolvaptan in refractory ascites has been reported; however, there are no reports on the efficacy or safety of tolvaptan for refractory ascites after hepatic resection. This study aims to evaluate the efficacy of early administration of tolvaptan in patients with refractory ascites after hepatic resection...
March 2024: International journal of surgery protocols
https://read.qxmd.com/read/38429139/aetiology-and-diagnostic-utility-of-serum-ascites-albumin-gradient-in-children-with-ascites
#10
JOURNAL ARTICLE
Srinivas Srinidhi Vadlapudi, Anshu Srivastava, Nidhi Saini, Moinak Sen Sarma, Ujjal Poddar, Surender Kumar Yachha
BACKGROUND: Ascites in children is multifactorial and serum ascites albumin gradient (SAAG) ≥1.1 helps differentiate portal hypertension (PHTN) related from non-PHTN ascites. AIMS: We evaluated the aetiology and diagnostic accuracy of SAAG in children with ascites. METHODS: Children with ascites were retrospectively evaluated. Etiological diagnosis was based on clinical presentation and investigations. All cases with ascitic fluid analysis and a definite diagnosis were included for calculating the utility of SAAG...
February 29, 2024: Digestive and Liver Disease
https://read.qxmd.com/read/38396896/assessment-of-the-impact-of-carvedilol-administered-together-with-dexrazoxan-and-doxorubicin-on-liver-structure-and-function-iron-metabolism-and-myocardial-redox-system-in-rats
#11
JOURNAL ARTICLE
Jaroslaw Szponar, Agnieszka Gorska, Marta Ostrowska-Lesko, Agnieszka Korga-Plewko, Michal Tchorz, Erwin Ciechanski, Anna Dabrowska, Ewa Poleszak, Franciszek Burdan, Jaroslaw Dudka, Marek Murias, Slawomir Mandziuk
Late cardiotoxicity is a formidable challenge in anthracycline-based anticancer treatments. Previous research hypothesized that co-administration of carvedilol (CVD) and dexrazoxane (DEX) might provide superior protection against doxorubicin (DOX)-induced cardiotoxicity compared to DEX alone. However, the anticipated benefits were not substantiated by the findings. This study focuses on investigating the impact of CVD on myocardial redox system parameters in rats treated with DOX + DEX, examining its influence on overall toxicity and iron metabolism...
February 13, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38374552/midodrine-reduces-new-onset-acute-kidney-injury-and-hyponatremia-in-children-with-cirrhosis-and-ascites-awaiting-liver-transplantation-results-from-an-open-label-rct
#12
RANDOMIZED CONTROLLED TRIAL
A Ashritha, Bikrant B Lal, Rajeev Khanna, Vikrant Sood, Arun K Sood, Seema Alam
OBJECTIVES: Midodrine, an oral α-1-adrenergic receptor agonist, counters arterial hypovolemia and reduces complications in adult patients with cirrhosis. This randomized controlled trial (RCT) aimed to assess the efficacy and safety of midodrine in preventing complications and improving survival in children with cirrhosis and ascites who are awaiting liver transplantation (LT). METHODS: This open-label RCT conducted from January 2022 to May 2023 included children under 18 years with cirrhosis and ascites...
February 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38357146/risk-factors-analysis-of-endoscopy-and-tips-in-the-treatment-of-secondary-esophagogastric-varicose-bleeding-with-cirrhosis
#13
JOURNAL ARTICLE
Xiaoyan Liu, Yanli Wang, Lei Zheng, Jinzhao Zhu
OBJECTIVE: To analyse the risk factors of secondary hemorrhage and survival rate in cirrhotic patients with esophagogastric variceal rupture and to compare the efficacy and safety of endoscopic hemostasis and TIPS (transjugular intrahepatic portosystemic shunt). METHODS: A total of 120 patients with secondary bleeding after endoscopic treatment of esophagogastric varicose bleeding with cirrhosis in our hospital during the past 3 years were retrospectively analysed...
September 2023: African Health Sciences
https://read.qxmd.com/read/38355195/personalised-human-albumin-in-patients-with-cirrhosis-and-ascites-design-and-rationale-for-the-alb-trial-a-randomised-clinical-biomarker-validation-trial
#14
RANDOMIZED CONTROLLED TRIAL
Nikolaj Torp, Mads Israelsen, Minneke Coenraad, Maria Papp, Debbie Shawcross, Marko Korenjak, Paolo Angeli, Wim Laleman, Adria Juanola, Pere Gines, Jonel Trebicka, Aleksander Krag
INTRODUCTION: Human albumin is used in the treatment of complications of cirrhosis. However, the use of long-term human albumin administration is costly and resource demanding for both patients and healthcare systems. A precision medicine approach with biomarkers to predict human albumin treatment response, so-called predictive biomarkers, could make this a viable treatment option in patients with cirrhosis and ascites. METHODS AND ANALYSIS: ALB-TRIAL is a multinational, double-blind, placebo-controlled randomised controlled trial...
February 14, 2024: BMJ Open
https://read.qxmd.com/read/38340308/recent-developments-in-the-management-of-ascites-in-cirrhosis
#15
REVIEW
Tian Lan, Ming Chen, Chengwei Tang, Pierre Deltenre
In recent years, advances have been made for treating ascites in patients with cirrhosis. Recent studies have indicated that several treatments that have been used for a long time in the management of portal hypertension may have beneficial effects that were not previously identified. Long-term albumin infusion may improve survival in patients with cirrhosis and ascites while beta-blockers may reduce ascites occurrence. Transjugular intrahepatic porto-systemic shunt (TIPS) placement may also improve survival in selected patients in addition to the control with ascites...
February 10, 2024: United European Gastroenterology Journal
https://read.qxmd.com/read/38337613/efficacy-and-safety-of-a-probiotic-containing-saccharomyces-boulardii-cncm-i-745-in-the-treatment-of-small-intestinal-bacterial-overgrowth-in-decompensated-cirrhosis-randomized-placebo-controlled-study
#16
JOURNAL ARTICLE
Irina Efremova, Roman Maslennikov, Maria Zharkova, Elena Poluektova, Nona Benuni, Aleksandr Kotusov, Tatyana Demina, Aleksandra Ivleva, Farida Adzhieva, Taisiya Krylova, Vladimir Ivashkin
(1) Background : The aim was to evaluate the effectiveness of the probiotic containing Saccharomyces boulardii in the treatment of small intestinal bacterial overgrowth (SIBO) in patients with decompensated cirrhosis. (2) Methods : This was a blinded, randomized, placebo-controlled study. (3) Results : After 3 months of treatment, SIBO was absent in 80.0% of patients in the probiotic group and in 23.1% of patients in the placebo group ( p = 0.002). The patients with eliminated SIBO had decreased frequency of ascites and hepatic encephalopathy, the increased platelets and albumin levels, the decreased blood levels of total bilirubin, biomarkers of bacterial translocation (lipopolysaccharide [LPS]) and systemic inflammation (C-reactive protein), and positive changes in markers of hyperdynamic circulation compared with the state at inclusion...
February 5, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38331713/possible-use-of-2d-shear-wave-liver-elastography-in-new-onset-ascites-evaluation
#17
JOURNAL ARTICLE
Andrej Hari, Borut Štabuc
BACKGROUND: No data on the use of 2D shear wave elastography exists regarding the evaluation of the new-onset ascites causality. AIMS: To determine whether 2D shear wave elastography can help in the non-invasive assessment of the new-onset ascites cause. To assess the applicability of liver stiffness measured by 2D shear wave elastography using Esaote MyLab Nine apparatus in patients with ascites. METHODS: In 52 consecutive patients with new-onset ascites (January 2020 to October 2021), liver stiffness using 2D shear wave elastography was prospectively measured...
February 8, 2024: BMC Gastroenterology
https://read.qxmd.com/read/38326201/impact-of-total-parenteral-nutrition-on-preoperative-management-of-pediatric-living-donor-liver-transplantation-for-biliary-atresia-under-2-years-old
#18
JOURNAL ARTICLE
Takehisa Ueno, Koki Takase, Koichi Deguchi, Motonari Nomura, Miho Watanabe, Masafumi Kamiyama, Yuko Tazuke, Takeshi Kimura, Hiroomi Okuyama
BACKGROUND: Liver failure and gastrointestinal bleeding occur in the end-stage of biliary atresia (BA). Living-donor liver transplantation (LDLT) is a standard treatment in Japan. Our program actively provides pre-transplant total parenteral nutrition (TPN) for such patients, and here we report its efficiency and safety. METHODS: Patients with BA for whom LDLT was indicated were identified. Those with a long-term external central venous catheter and TPN, longer than 4 weeks before LDLT, were analyzed...
February 6, 2024: Transplantation Proceedings
https://read.qxmd.com/read/38307583/viscosity-and-characteristics-of-malignant-ascites
#19
JOURNAL ARTICLE
Kosuke Maehara, Susumu Hijioka, Kotaro Takeshita, Atsushi Kanno, Takuji Okusaka
BACKGROUND/AIM: Malignant ascites is a common condition in patients with terminal cancer. Treatments, such as diuretics, percutaneous drainage of ascites, and abdominal vein shunting have been advocated. However, these treatments have not achieved sufficient palliative effects. Therefore, the development of innovative therapies is mandated, especially for new therapies that require the creation of a fluid simulation of malignant ascites. However, there have been no previous studies on the physical properties of malignant ascites, including viscosity, which are necessary for the development of such a fluid...
February 2024: Anticancer Research
https://read.qxmd.com/read/38292843/development-and-validation-of-a-machine-learning-based-early-prediction-model-for-massive-intraoperative-bleeding-in-patients-with-primary-hepatic-malignancies
#20
JOURNAL ARTICLE
Jin Li, Yu-Ming Jia, Zhi-Lei Zhang, Cheng-Yu Liu, Zhan-Wu Jiang, Zhi-Wei Hao, Li Peng
BACKGROUND: Surgical resection remains the primary treatment for hepatic malignancies, and intraoperative bleeding is associated with a significantly increased risk of death. Therefore, accurate prediction of intraoperative bleeding risk in patients with hepatic malignancies is essential to preventing bleeding in advance and providing safer and more effective treatment. AIM: To develop a predictive model for intraoperative bleeding in primary hepatic malignancy patients for improving surgical planning and outcomes...
January 15, 2024: World Journal of Gastrointestinal Oncology
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