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Ascites and albumin

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https://www.readbyqxmd.com/read/29643915/prognostic-significance-of-blood-serum-and-ascites-parameters-in-patients-with-malignant-peritoneal-mesothelioma-or-peritoneal-carcinomatosis
#1
Shan-Shan Su, Guo-Qi Zheng, Wen-Jie Yin, Yu-Fei Liang, Ying-Ying Liu, Hui Song, Ning-Ning Sun, Yu-Xin Yang
To determine effects of the biochemical and cytological properties of blood, serum, and ascites on survival of patients with malignant peritoneal effusion (MPeE), including malignant peritoneal mesothelioma (MPeM) and peritoneal carcinomatosis (PC), we conducted a retrospective study of patients with MPeE and healthy controls. Potential prognostic factors were identified as follows: age, sex, blood neutrophil-to-lymphocyte ratio (NLR), serum parameters, ascites parameters, serum-ascites albumin gradient, and the ascites-serum LDH ratio...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29609068/cost-effectiveness-of-early-insertion-of-transjugular-intrahepatic-portosystemic-shunts-for-recurrent-ascites
#2
Nicole T Shen, Yecheskel Schneider, Stephen E Congly, Russell E Rosenblatt, Yunseok Namn, Brett E Fortune, Arun Jesudian, Robert S Brown
BACKGROUND & AIMS: Treatment options for recurrent ascites resulting from decompensated cirrhosis include serial large volume paracentesis and albumin infusion (LVP+A) or insertion of a transjugular intrahepatic portosystemic shunt (TIPS). Insertion of TIPSs with covered stents during early stages of ascites (early TIPS, defined as 2 LVPs within the past 3 weeks and less than 6 LVPs in the prior 3 months) significantly improves chances of survival and reduces complications of cirrhosis compared to LVP+A...
March 30, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29605778/cirrhosis-following-single-anastomosis-duodeno-ileal-switch-a-case-report
#3
Vincent Kirkpatrick, Rena C Moon, Andre F Teixeira, Muhammad A Jawad
INTRODUCTION: Single anastomosis duodeno-ileal switch (SADI-S) involves a single, loop duodeno-ileal anastomosis with omission of the traditional Roux-en-Y distal ileo-ileal anastomosis. Not much has been published on the complications of SADI-S. PRESENTATION OF CASE: The patient is a 40 year-old male who underwent robot-assisted SADI-S three years prior. At the time of surgery, his body mass index (BMI) was 69 kg/m2 . His BMI was 31 kg/m2 at the time of presentation...
March 17, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29581807/the-prevalence-and-implication-of-zinc-deficiency-in-patients-with-chronic-liver-disease
#4
Kazuhiro Katayama, Takumi Kawaguchi, Koichi Shiraishi, Toshifumi Ito, Kazutomo Suzuki, Chizu Koreeda, Takaaki Ohtake, Motoh Iwasa, Yoshio Tokumoto, Ryujin Endo, Naohiro Kawamura, Makoto Shiraki, Tatsunori Hanai, Daiki Habu, Satoru Tsuruta, Hironori Sakai, Yoshiyuki Miwa, Norifumi Kawada, Akinobu Kato, Yoshiyuki Takei, Tetsuya Mine, Yutaka Kohgo, Toshihito Seki, Michio Sata, Yuri Ito, Keisuke Fukui, Shuhei Nishiguchi, Hisataka Moriwaki, Kazuyuki Suzuki
Background: Patients with liver cirrhosis often exhibit zinc deficiency. Although zinc is involved in many bioactivities, many aspects of clinical implications of zinc deficiency in liver cirrhosis remain unclear. We aimed to reveal the prevalence and implications of zinc deficiency in liver cirrhosis by assessing associations with parameters such as clinical symptoms and laboratory data. Methods: In 235 cirrhosis patients enrolled at multiple medical institutions in 2009, we assessed how blood zinc levels were associated with their clinical symptoms, patients characteristics, and liver function test results...
May 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29535028/baseline-factors-associated-with-improvements-in-decompensated-cirrhosis-after-direct-acting-antiviral-therapy-for-hcv-infection
#5
O El-Sherif, Z G Jiang, E B Tapper, K C Huang, A Zhong, A Osinusi, M Charlton, M Manns, N H Afdhal, K Mukamal, J McHutchison, D M Brainard, N Terrault, M P Curry
BACKGROUND & AIMS: Treatment with direct-acting antiviral (DAA) agents can reduce model for end-stage liver disease and Child-Pugh-Turcotte (CPT) scores in patients with decompensated cirrhosis caused by hepatitis C virus (HCV). However, many of these patients still die or require liver transplantation. We collected data on baseline features of patients and aimed to develop a scoring system to predict response to DAA therapy. METHODS: We performed a retrospective analysis of data from 4 trials of the effects of sofosbuvir-based therapy in patients with HCV-associated decompensated cirrhosis (502 of CPT class B and 120 of CPT class C)...
March 10, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29521663/predicting-mortality-in-patients-with-spontaneous-bacterial-peritonitis-using-routine-inflammatory-and-biochemical-markers
#6
Raim Iliaz, Tahsin Ozpolat, Bulent Baran, Kadir Demir, Sabahattin Kaymakoglu, Fatih Besisik, Filiz Akyuz
OBJECTIVES: Spontaneous bacterial peritonitis (SBP) is a common and high-mortality infectious complication of patients with cirrhosis. New inflammatory markers are associated with morbidity/mortality in various diseases. The aim of our study was to find the 30-day mortality rate of SBP and their predictors. PATIENTS AND METHODS: Seventy patients with cirrhosis complicated with SBP and 55 non-SBP controls were enrolled into the study, and patients were evaluated for mortality rate and its predictors...
March 8, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29516241/albumin-bilirubin-and-platelet-albumin-bilirubin-grades-do-not-predict-survival-after-transjugular-intrahepatic-portosystemic-shunt-creation
#7
Ramzy C Khabbaz, R Peter Lokken, Yi-Fan Chen, Andrew J Lipnik, James T Bui, Charles E Ray, Ron C Gaba
PURPOSE: To evaluate the capability of albumin-bilirubin (ALBI) and platelet-albumin-bilirubin (PALBI) grades in predicting transplant-free survival (TFS) in patients undergoing transjugular intrahepatic portosystemic shunt (TIPS) creation. MATERIALS AND METHODS: This single-center retrospective study included 342 ALBI and 337 PALBI patients (62% men; age 53-54 years) with cirrhosis (median MELD 15) and portal hypertension complications (variceal bleeding, 55%; ascites, 35%; other, 10%) who underwent TIPS between 1998 and 2017...
March 7, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29512744/therapeutic-effects-of-antimicrobial-peptide-on-malignant-ascites-in-a-mouse-model
#8
Li-Jie Xia, Yan-Ling Wu, Ji Ma, Fu-Chun Zhang
The primary objective of the treatment of malignant ascites in advanced stages is to alleviate symptoms using procedures such as diuresis, paracentesis of subretinal fluid and vena cava anastomosis. The effectiveness of systemic or intraperitoneal chemotherapy treatment is limited, and more efficacious therapies are required. The authors of the present study demonstrated that an antimicrobial peptide, cecropinXJ, isolated from the larvae of Bombyx mori, selectively inhibits the proliferation of gastric cancer cells...
March 7, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29491636/viwithan-a-standardized-withania-somnifera-root-extract-induces-apoptosis-in-murine-melanoma-cells
#9
H V Sudeep, K Gouthamchandra, B J Venkatesh, K Shyam Prasad
Background: Withania somnifera is an Indian medicinal herb known for the multipotential ability to cure various therapeutic ailments as described in the ayurvedic system of medicine. Objective: In the present study, we have evaluated the antiproliferative activity of a standardized W. somnifera root extract (Viwithan) against different human and murine cancer cell lines. Materials and Methods: The cytotoxicity of Viwithan was determined using thiazolyl blue tetrazolium blue assay and crystal violet staining...
January 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29484654/ablation-approach-for-primary-liver-tumors-peri-operative-outcomes
#10
Nicholas G Berger, Josi L Herren, Chrissy Liu, Robert H Burrow, Jack P Silva, Susan Tsai, Kathleen K Christians, T Clark Gamblin
BACKGROUND AND OBJECTIVES: Ablation is a common treatment modality for malignant primary liver tumors(PLTs), outcomes following laparoscopic (LA) versus open ablation (OA) are ill-defined. This project compares peri-procedural outcomes of LA versus OA for PLTs. MATERIALS AND METHODS: Patients with PLTs undergoing radiofrequency ablation were queried from ACS NSQIP Database (2005-2013) using CPT codes. Patients undergoing percutaneous ablation or hepatic resection were excluded...
February 26, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29481770/biochemical-studies-of-egyptian-sweet-orange-hesperidin-on-ehrlich-ascites-carcinoma-eac-bearing-mice
#11
Thoria Donia, Marian Nabil, Tarek M Mohamed
There are global increased interests to identify novel agents that can possess anti-tumor effects or maximize the anti-tumor effects of low doses for conventional anti-cancer drugs. The aim of this study was to investigate anti-tumor effects and protective role of isolated hesperidin from sweet orange on doxorubicin-induced toxicity in Ehrlich ascites carcinoma (EAC) bearing mice. Tumor cells were injected into Swiss albino mice followed by hesperidin administration either alone or in combination with doxorubicin...
February 23, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29472420/budd-chiari-syndrome-in-a-patient-with-ulcerative-colitis
#12
Gopal Krishana Bohra, Vivek Chhabra, Naresh Midha, Binit Sureka
We report a case of 26-year-old man who was admitted on our ward for the evaluation of ascites. He was a known case of inflammatory bowel disease(ulcerative colitis) and was on regular mesalamine therapy. On evaluation, he was having high serum ascites albumin gradient. CT scan of the abdomen revealed features of portal hypertension and non-visualisation of right and middle hepatic veins along with thrombus in inferior vena cava, suggesting a diagnosis of Budd-Chiari syndrome (BCS). There are only few case reports available showing association of BCS with UC...
February 22, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29471786/dengue-score-as-a-diagnostic-predictor-for-pleural-effusion-and-or-ascites-external-validation-and-clinical-application
#13
Suhendro Suwarto, Mohammad Jauharsyah Hidayat, Bing Widjaya
BACKGROUND: The Dengue Score is a model for predicting pleural effusion and/or ascites and uses the hematocrit (Hct), albumin concentration, platelet count and aspartate aminotransferase (AST) ratio as independent variables. As this metric has not been validated, we conducted a study to validate the Dengue Score and assess its clinical application. METHODS: A retrospective study was performed at a private hospital in Jakarta, Indonesia. Patients with dengue infection hospitalized from January 2011 through March 2016 were included...
February 23, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29465591/a-study-on-risk-factors-and-diagnostic-efficiency-of-posthepatectomy-liver-failure-in-the-nonobstructive-jaundice
#14
He Wang, Shi-Chun Lu, Lei He, Jia-Hong Dong
Liver failure remains as the most common complication and cause of death after hepatectomy, and continues to be a challenge for doctors.t test and χ test were used for single factor analysis of data-related variables, then results were introduced into the model to undergo the multiple factors logistic regression analysis. Pearson correlation analysis was performed for related postoperative indexes, and a diagnostic evaluation was performed using the receiver operating characteristic (ROC) of postoperative indexes...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29432847/ascitic-fluid-from-advanced-ovarian-cancer-patients-compromises-the-activity-of-receptor-tyrosine-kinase-inhibitors-in-3d-cell-clusters-of-ovarian-cancer-cells
#15
Wafaa Hassan, Kenny Chitcholtan, Peter Sykes, Ashley Garrill
Ovarian cancer patients in the advanced stages of the disease show clinical ascites, which is associated with a poor prognosis. There is limited understanding of the effect of ascitic fluid on ovarian cancer cells and their response to anticancer drugs. We investigated the antitumour effects of EGFR/Her-2 (canertinib) and c-Met (PHA665752) inhibitors in a 3D cell model of three ovarian cancer lines. Single and combined inhibitor treatments affected cell growth of OVCAR-5 and SKOV-3 cell lines but not OV-90 cell line...
February 9, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29427038/efficacy-and-tolerability-of-ramucirumab-monotherapy-or-in-combination-with-paclitaxel-in-gastric-cancer-patients-from-the-expanded-access-program-cohort-by-the-korean-cancer-study-group-kcsg
#16
Minkyu Jung, Min-Hee Ryu, Do Youn Oh, Myounghee Kang, Dae Young Zang, In Gyu Hwang, Keun-Wook Lee, Ki Hyang Kim, Byoung Yong Shim, Eun Kee Song, Sun Jin Sym, Hye Sook Han, Young Lee Park, Jin Soo Kim, Hyun Woo Lee, Moon Hee Lee, Dong-Hoe Koo, Hong Suk Song, Namsu Lee, Sung Hyun Yang, Dae Ro Choi, Young Seon Hong, Kyoung Eun Lee, Chi Hoon Maeng, Jin Ho Baek, Samyong Kim, Yeul Hong Kim, Sun Young Rha, Jae Yong Cho, Yoon-Koo Kang
BACKGROUND: Ramucirumab improves survival in gastric cancer patients. The efficacy and safety of ramucirumab outside of a clinical trial were evaluated using an expanded access program (EAP). METHODS: Advanced gastric cancer patients treated with ramucirumab in combination with paclitaxel or with ramucirumab monotherapy in a Korean EAP were evaluated. Baseline characteristics were assessed for progression-free survival (PFS) and overall survival (OS), and adverse events were evaluated according to the treatment regimen...
February 9, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29417691/incidence-risk-factors-and-outcomes-related-with-neurological-events-after-liver-transplantation-in-adult-and-pediatric-recipients
#17
Federico Piñero, Yu Cheang, Manuel Mendizabal, Joaquín Cagliani, Ariel Gonzalez Campaña, Josefina Pages, Carla Colaci, Mariano Barreiro, Cristina Alonso, Ivone Malla, Martín Fauda, Jose Bueri, Luis G Podesta, Marcelo Silva
Controversy exists whether NE after LT are more frequently observed in children or adults. We aimed to compare the incidence and outcomes for NE after LT in pediatric and adult recipients. A single-center cohort study, including all LT between 2001 and 2013, was performed. Definition of NE included impaired consciousness, delirium, seizures, focal neurologic deficit, visual impairment, or slurred speech. A cohort of 443 consecutive LT recipients was included: 307 adults and 136 children. Cumulative incidence of NE was similar between adults 15% (n = 41) and children 16% (n = 20; P = ...
February 7, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29415840/palliative-home-parenteral-nutrition-clinical-service-evaluation-and-identifying-potential-prognostic-factors-to-assist-with-patient-selection
#18
B Drinkwater, B K Clarke, J Jones, J Ratcliffe, P Deel-Smith, S C Cooper
BACKGROUND AND AIMS: Home parenteral nutrition (HPN) for palliation has little evidence supporting existing guidance. Patient selection remains challenging. We aimed to evaluate use of palliative HPN in our service against ESPEN guidance, and to identify potential prognostic indicators. METHODS: Palliative care patients commenced on HPN were identified. Medical notes, computer records and HPN database were accessed to identify patient demographics, primary diagnosis and aetiology of intestinal failure, blood test results potentially associated with prognosis (eGFR, albumin, CRP, Hb), presence of ascites, and PN duration...
December 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29411667/prognosis-of-patients-with-ascites-after-pleurx-insertion-an-observational-study
#19
Agnete Nordheim Riedel, Nina Kimer, Lise Hobolth, Lise Lotte Gluud
OBJECTIVE: To evaluate the safety of PleurX in cirrhotic patients with refractory ascites. METHODS: We prospectively registered patients who received a PleurX catheter cirrhosis-associated refractory ascites at our department from July 2015 to November 2016. Our control group consisted of matched cirrhotic patients with refractory ascites treated with large volume paracentesis (LVP) and patients with malignant ascites treated with PleurX during the same period. RESULTS: We included 25 patients with cirrhosis-related ascites (7 in PleurX group) and 17 with malignant ascites (14 in PleurX group)...
March 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29394556/-a-case-of-huge-colon-cancer-accompanied-with-severe-hypoproteinemia
#20
Sakurao Hiraki, Kou Kanesada, Toshio Harada, Kousuke Tada, Shintaro Fukuda
We report a case of huge colon cancer accompanied with severe hypoproteinemia. A7 4-year-old woman was referred to our hospital because of abdominal fullness. Blood examinations revealed anemia(hemoglobin 8.8 g/dL)and sever hypopro- teinemia(total protein 4.5 g/dL, albumin 1.1 g/dL). Computed tomography examination of abdomen revealed ascites and large tumor(12.5×10.5 cm)at the right side colon. By further examinations ascending colon cancer without distant metastasis was diagnosed, then we performed right hemicolectomy and primary intestinal anastomosis by open surgery...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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