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https://www.readbyqxmd.com/read/29774546/pepsin-biomarker-mediator-and-therapeutic-target-for-reflux-and-aspiration
#1
REVIEW
Nikki Johnston, Peter W Dettmar, Frank G Ondrey, Rahul Nanchal, Sang-Hyuk Lee, Jonathan M Bock
Extra-esophageal reflux is suspected to cause a wide range of clinical symptoms in the upper airways. Diagnosis and treatment has focused on acid, but realization of the role of nonacid reflux has resulted in research investigating the use of pepsin as a biomarker for gastric reflux and aspiration. Pepsin analysis can complement the use of questionnaires and office-based diagnosis and lessen the dependency on invasive and expensive diagnostic tests. Furthermore, pepsin as a first-line diagnostic biomarker has been shown to improve the accuracy of reflux diagnosis...
May 17, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29730088/aspiration-pneumonia-and-related-syndromes
#2
REVIEW
Augustine S Lee, Jay H Ryu
Aspiration is a syndrome with variable respiratory manifestations that span acute, life-threatening illnesses, such as acute respiratory distress syndrome, to chronic, sometimes insidious, respiratory disorders such as aspiration bronchiolitis. Diagnostic testing is limited by the insensitivity of histologic testing, and although gastric biomarkers for aspiration are increasingly available, none have been clinically validated. The leading mechanism for microaspiration is thought to be gastroesophageal reflux disease, largely driven by the increased prevalence of gastroesophageal reflux across a variety of respiratory disorders, including chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis, and chronic cough...
May 2, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29521269/the-effect-of-darbepoetin-alfa-on-renal-fibrosis-in-rats-with-acute-unilateral-ureteral-obstruction
#3
Ozgur Haki Yuksel, Caglar Yildirim, Ahmet Urkmez, Nurver Ozbay, Fatih Uruc, Aytac Sahin, Serkan Akan, Ayhan Verit
OBJECTIVES: The most important treatment strategy for obstructive nephropathy is to protect renal tissue from the deleterious effects of fibrosis. Therefore, we sought to investigate the renoprotective effects of darbepoetin alfa on unilateral ureteral obstructions. METHODS: We used 12 female and 12 male 3-monthold Wistar rats weighing between 250 and 350 g. The rats were divided equally into sham, darbepoetin and control groups. With the exception of the sham group, left unilateral obstructions were applied to all of the rats...
March 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29484193/serological-biomarker-testing-helps-avoiding-unnecessary-endoscopies-in-obese-patients-before-bariatric-surgery
#4
Jaanus Suumann, Toomas Sillakivi, Živile Riispere, Kari Syrjänen, Pentti Sipponen, Ülle Kirsimägi, Ants Peetsalu
Background: To assess the value of serological biomarker testing as a substitute for esophagogastroduodenoscopy (EGDS) in pre-operative assessment of patients referred for bariatric surgery. Methods: Sixty-five obese patients with a mean age of 43 years (range: 21-65) and a mean body mass index (BMI) of 44 (range: 36-59) were studied. The patients were tested with a four-biomarker panel: pepsinogen I and II, gastrin-17 (basal and stimulated), and Helicobacter pylori (HP) antibodies (GastroPanel®, Biohit Oyj, Finland)...
2018: BMC Obesity
https://www.readbyqxmd.com/read/29473241/immunohistochemical-assessment-of-survivin-and-bcl3-expression-as-potential-biomarkers-for-nf-%C3%AE%C2%BAb-activation-in-the-barrett-metaplasia-dysplasia-adenocarcinoma-sequence
#5
Ignazio Puccio, Saif Khan, Adil Butt, David Graham, Vinay Sehgal, Dominic Patel, Marco Novelli, Laurence B Lovat, Manuel Rodriguez-Justo, Rifat A Hamoudi
Non-dysplastic Barrett's oesophagus (NDBE) occurs as a consequence of an inflammatory response triggered through prolonged gastro-oesophageal reflux and it may precede the development of oesophageal adenocarcinoma. NF-κB activation as a result of the inflammatory response has been shown in NDBE, but the possible mechanism involved in the process is unknown. The aim of this study was to assess, using immunohistochemistry, Survivin and Bcl3 expression as potential biomarkers for NF-κB activation along the oesophageal metaplasia-dysplasia-adenocarcinoma sequence...
February 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29449669/predictive-biomarkers-of-gastroesophageal-reflux-disease-and-barrett-s-esophagus-in-world-trade-center-exposed-firefighters-a-15-year-longitudinal-study
#6
Syed H Haider, Sophia Kwon, Rachel Lam, Audrey K Lee, Erin J Caraher, George Crowley, Liqun Zhang, Theresa M Schwartz, Rachel Zeig-Owens, Mengling Liu, David J Prezant, Anna Nolan
Gastroesophageal reflux disease (GERD) and Barrett's Esophagus (BE), which are prevalent in the World Trade Center (WTC) exposed and general populations, negatively impact quality of life and cost of healthcare. GERD, a risk factor of BE, is linked to obstructive airways disease (OAD). We aim to identify serum biomarkers of GERD/BE, and assess the respiratory and clinical phenotype of a longitudinal cohort of never-smoking, male, WTC-exposed rescue workers presenting with pulmonary symptoms. Biomarkers collected soon after WTC-exposure were evaluated in optimized predictive models of GERD/BE...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330747/recent-advances-in-screening-for-barrett-s-esophagus
#7
REVIEW
Sarmed S Sami, Prasad G Iyer
OPINION STATEMENT: PURPOSE OF REVIEW: There is a pressing need for effective strategies to halt the increase in both the incidence and mortality of esophageal adenocarcinoma (EAC). Screening for Barrett's esophagus, which is the only known precursor of EAC, remains a ripe area for research, particularly with regard to identifying the target population, screening tools, and management of screen-detected populations. This review aims to explore in depth the rationale for screening for Barrett's esophagus, recent biotechnological advances which may have the potential of making screening feasible, and also highlight the challenges which will have to be overcome in order make screening for BE a realistic prospect...
March 2018: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29306986/d-dimer-as-a-marker-of-acute-pyelonephritis-in-infants-younger-than-24-months-with-urinary-tract-infection
#8
Jung Won Lee, Sun Mi Her, Ji Hong Kim, Keum Hwa Lee, Michael Eisenhut, Se Jin Park, Jae Il Shin
BACKGROUND: D-dimer, as well as other biomarkers related to coagulation, is significantly increased during severe bacterial infection and sepsis. The aim of this study was to evaluate the usefulness of serum D-dimer as a biological marker in diagnosing acute pyelonephritis (APN) and in predicting vesicoureteric reflux (VUR) in infants with urinary tract infection (UTI). METHODS: We retrospectively analyzed the data of 177 young infants (<2 years) with febrile UTI between 2005 and 2014, grouped as APN and lower UTI groups...
April 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29258183/the-lung-microbiome-in-idiopathic-pulmonary-fibrosis-a-promising-approach-for-targeted-therapies
#9
REVIEW
Aline Fastrès, Florence Felice, Elodie Roels, Catherine Moermans, Jean-Louis Corhay, Fabrice Bureau, Renaud Louis, Cécile Clercx, Julien Guiot
This review focuses on the role of the lung microbiome in idiopathic pulmonary fibrosis. Although historically considered sterile, bacterial communities have now been well documented in lungs both in healthy and pathological conditions. Studies in idiopathic pulmonary fibrosis (IPF) suggest that increased bacterial burden and/or abundance of potentially pathogenic bacteria may drive disease progression, acute exacerbations, and mortality. More recent work has highlighted the interaction between the lung microbiome and the innate immune system in IPF, strengthening the argument for the role of both host and environment interaction in disease pathogenesis...
December 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29238875/pepsin-in-saliva-as-a-diagnostic-biomarker-in-laryngopharyngeal-reflux-a-meta-analysis
#10
REVIEW
Jing Wang, Yu Zhao, Jianjun Ren, Yang Xu
OBJECTIVE: Pepsin in saliva has been proposed as a biomarker for the diagnosis of laryngopharyngeal reflux (LPR), but the results remain controversial. We assessed the diagnostic value of pepsin in saliva for LPR. METHODS: PubMed, Embase, and Web of Science were searched for studies in English that evaluated the utility of pepsin in saliva in the diagnosis of LPR, published up to 15 March 2017. We used Stata 12.0 to summarize the diagnostic indexes for the meta-analysis...
March 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29071486/fragments-of-e-cadherin-as-biomarkers-of-non-erosive-reflux-disease
#11
Biljana Jovov, Craig C Reed, Nicholas J Shaheen, Amy Pruitt, Kathleen Ferrell, Geraldine S Orlando, Zorka Djukic, Roy C Orlando
BACKGROUND: Approximately, 20% of patients with heartburn and normal endoscopic findings do not symptomatically improve on proton pump inhibitor (PPI) therapy making diagnosis and treatment uncertain. A biomarker distinguishing PPI-responsive from PPI-refractory heartburn is desirable. AIMS: We performed a pilot study assessing whether carboxy(C)-terminal fragments (CTFs) of e-cadherin in esophageal biopsies or amino(N)-terminal fragments (NTFs) of e-cadherin in serum could serve this purpose...
March 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29041918/the-diagnostic-value-of-pepsin-detection-in-saliva-for-gastro-esophageal-reflux-disease-a-preliminary-study-from-china
#12
Xing Du, Feng Wang, Zhiwei Hu, Jimin Wu, Zhonggao Wang, Chao Yan, Chao Zhang, Juan Tang
BACKGROUND: None of current diagnostic methods has been proven to be a reliable tool for gastro-esophageal reflux disease (GERD). Pepsin in saliva has been proposed as a promising diagnostic biomarker for gastro-esophageal reflux. We aimed to determine the diagnostic value of salivary pepsin detection for GERD. METHODS: Two hundred and fifty patients with symptoms suggestive of GERD and 35 asymptomatic healthy volunteers provided saliva on morning waking, after lunch and dinner for pepsin determination using the Peptest lateral flow device...
October 17, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28952702/-reflux-nephropathy-in-children-early-diagnosis-and-monitoring
#13
REVIEW
O L Morozova, D A Morozov, D Y Lakomova, V V Iakovlev, V V Rostovskaya, I A Budnik, L D Maltseva
Vesicoureteral reflux (VUR) is the most common type of obstructive uropathy in children. Reflux nephropathy (RN) is one of the most common complications of VUR that inevitably leads to chronic kidney disease. Patients with end-stage kidney disease require costly treatment, and the only way to cure them is kidney transplantation. A timely institution of renoprotective therapy is a key factor helping to preserve the function of the native kidneys. Hence, it is necessary to devise new highly sensitive and minimally invasive methods for early diagnosis of RN...
September 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28906318/nutritional-state-and-feeding-behaviors-of-children-with-eosinophilic-esophagitis-and-gastroesophageal-reflux-disease
#14
Pooja Mehta, Glenn T Furuta, Taryn Brennan, Michelle L Henry, Nancy Creskoff Maune, Shikha S Sundaram, Calies Menard-Katcher, Dan Atkins, Faith Takurukura, Sandra Giffen, Zhaoxing Pan, Angela M Haas
OBJECTIVE: As both gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) are associated with malnutrition and feeding dysfunction, this study compares growth, nutrition, and feeding behaviors in children with GERD and EoE. METHODS: Subjects ages 1 to 7 years with GERD or EoE were enrolled in a prospective study. Assessments included length/height, weight, 3-day food diary, serum biomarkers of nutrition, and the Behavioral Pediatric Feeding Assessment Scale...
April 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28811703/barrett-s-oesophagus-current-controversies
#15
REVIEW
Chidi Amadi, Piers Gatenby
Oesophageal adenocarcinoma is rapidly increasing in Western countries. This tumour frequently presents late in its course with metastatic disease and has a very poor prognosis. Barrett's oesophagus is an acquired condition whereby the native squamous mucosa of the lower oesophagus is replaced by columnar epithelium following prolonged gastro-oesophageal reflux and is the recognised precursor lesion for oesophageal adenocarcinoma. There are multiple national and society guidelines regarding screening, surveillance and management of Barrett's oesophagus, however all are limited regarding a clear evidence base for a well-demonstrated benefit and cost-effectiveness of surveillance, and robust risk stratification for patients to best use resources...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28756936/detecting-laryngopharyngeal-reflux-by-immunohistochemistry-of-pepsin-in-the-biopsies-of-vocal-fold-leukoplakia
#16
Xia Gong, Xiao-Yun Wang, Li Yang, Ming-Jun Sun, Jun Du, Wei Zhang
Laryngopharyngeal reflux (LPR) may contribute to the development of laryngeal diseases including vocal fold leukoplakia. Clinical methods of determining LPR are limited. Pepsin, as an exogenous protein, is considered as a biomarker of LPR. The aim of the current study was, therefore, to detect pepsin by immunohistochemistry in the biopsies from patients with vocal fold leukoplakia, and by which, to determine the potential association of LPR and vocal leukoplakia. A total of 26 biopsies from patients with vocal fold leukoplakia were examined in comparison with 20 vocal fold biopsies from control subjects...
July 27, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28682989/the-role-of-esophageal-hypersensitivity-in-functional-heartburn
#17
REVIEW
Takashi Kondo, Hiroto Miwa
Functional heartburn (FH) is defined as a functional esophageal disorder characterized by symptoms of chronic heartburn with no apparent correlation to acid or nonacid reflux. In addition, its symptoms persist despite the lack of organic abnormalities or inflammation, esophageal motility disorders, or metabolic disorders. Although conditions presenting with esophageal symptoms without endoscopic abnormalities were previously categorized as nonerosive reflux disease, such conditions are now classified into 3 categories under Rome IV criteria: nonerosive reflux disease, reflux hypersensitivity, and FH...
August 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28650861/microbiome-in-interstitial-lung-disease-from-pathogenesis-to-treatment-target
#18
REVIEW
Margaret L Salisbury, MeiLan K Han, Robert P Dickson, Philip L Molyneaux
PURPOSE OF REVIEW: This review summarizes current knowledge of the role of the lung microbiome in interstitial lung disease and poses considerations of the microbiome as a therapeutic target. RECENT FINDINGS: Although historically considered sterile, bacterial communities have now been well documented in lungs in health and disease. Studies in idiopathic pulmonary fibrosis (IPF) suggest that increased bacterial burden and/or abundance of potentially pathogenic bacteria may drive disease progression, acute exacerbations, and mortality...
September 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28620964/does-gene-expression-in-laryngeal-subsites-differ-between-patients-with-laryngopharyngeal-reflux-and-controls
#19
J M Wood, D J Hussey, C M Woods, D Astill, D I Watson, B Lee, A S Carney
OBJECTIVE: To identify laryngeal mRNA gene changes in patients with laryngopharyngeal reflux (LPR). METHOD: Laryngeal biopsies from non-smoking LPR patients (n=10; Reflux Symptom Index (RSI) >12 and a Reflux Finding Score (RFS) >6) and controls (n=9; RSI <12 and RFS <6) were collected from four subsites (true vocal cord, false vocal cord, medial arytenoid and posterior commissure) of the larynx. qRT-PCR analyses were conducted on 20 reflux- and inflammation-related genes, including interleukins 6 and 8, cytokeratins 8 and 14, mucin genes MUC1, MUC2, MUC3B, MUC4, MUC5B, MUC6 and MUC7 and carbonic anhydrase III...
February 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28612057/imaging-studies-and-biomarkers-to-detect-clinically-meaningful-vesicoureteral-reflux
#20
REVIEW
Michaella Maloney Prasad, Earl Y Cheng
The work-up of a febrile urinary tract infection is generally performed to detect vesicoureteral reflux (VUR) and its possible complications. The imaging modalities most commonly used for this purpose are renal-bladder ultrasound, voiding cystourethrogram and dimercapto-succinic acid scan. These studies each contribute valuable information, but carry individual benefits and limitations that may impact their efficacy. Biochemical markers are not commonly used in pediatric urology to diagnose or differentiate high-risk disease, but this is the emerging frontier, which will hopefully change our approach to VUR in the future...
June 2017: Investigative and Clinical Urology
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