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Reflux cancer larynx

Khalaf Kridin, Shira Zelber-Sagi, Doron Comaneshter, Arnon D Cohen
Importance: The association of pemphigus vulgaris and pemphigus foliaceus with comorbid malignancies is yet to be firmly established. Objective: To estimate the association between pemphigus and a wide range of nonhematologic malignancies using one of the largest cohorts of patients with pemphigus to date. Design, Setting, and Participants: For this cross-sectional study, we used the computerized database of Clalit Health Services, the largest public health care provider organization in Israel insuring 4...
April 1, 2018: JAMA Dermatology
Steven A House, Eric L Fisher
Hoarseness is a common presentation in primary care practices. Combined with other voice-related changes, it falls under the umbrella diagnosis of dysphonia. Hoarseness has a number of causes, ranging from simple inflammatory processes to less common psychiatric disorders to more serious systemic, neurologic, or cancerous conditions. Medication-induced hoarseness is common and should be considered. The initial evaluation begins with a targeted history and physical examination, while also looking for signs of potential systemic etiologies...
December 1, 2017: American Family Physician
Hasan Özkan, Fatih Karakaya, Zihni Karaeren, Sibel Perçinel
Introduction: CA 19-9 is used as a tumor marker in colon, pancreas, biliary, and gastric cancers. Laryngeal cancer is the most common malignant epithelial tumor among head and neck cancers and has no specific tumor marker. Case report: A 66-year-old male patient had severe reflux symptoms during 5 years and had an isolated CA 19-9 elevation. Follow-up analysis revealed that he had larynx cancer and after laryngectomy, CA 19-9 levels decreased to normal range. Discussion: Currently, CA 19-9 is not a marker for malignancy...
January 2017: Euroasian Journal of Hepato-Gastroenterology
John Maret-Ouda, Karl Wahlin, Miia Artama, Nele Brusselaers, Martti Färkkilä, Elsebeth Lynge, Fredrik Mattsson, Eero Pukkala, Pål Romundstad, Laufey Tryggvadóttir, My von Euler-Chelpin, Jesper Lagergren
PURPOSE: To describe a newly created all-Nordic cohort of patients with gastro-oesophageal reflux disease (GORD), entitled the Nordic Antireflux Surgery Cohort (NordASCo), which will be used to compare participants having undergone antireflux surgery with those who have not regarding risk of cancers, other diseases and mortality. PARTICIPANTS: Included were individuals with a GORD diagnosis recorded in any of the nationwide patient registries in the Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) in 1964-2014 (with various start and end years in different countries)...
June 8, 2017: BMJ Open
C Tudor, C Branescu, C Savlovschi, A El-Khatib, H Pantu, A Nica, A M Dascalu, B Masoumeh, A S Tudor, S M Oprescu, D Serban
Aim. The present study aimed to perform a medico-surgical comparative analysis of the 2 most widely used techniques: gastrostomy with peritoneal collar versus percutaneous endoscopic gastrostomy, based on the vast clinical experience in an Upper Digestive Surgery Clinic. Materials and method. A retrospective study was carried out between January 2010 and January 2015 on the patients admitted for a surgical solution for feeding. The indications, preoperative preparation, surgical techniques, and postoperative outcomes were analyzed...
October 2016: Journal of Medicine and Life
Kuen-Tze Lin, Chun-Shu Lin, Shih-Yu Lee, Wen-Yen Huang, Wei-Kuo Chang
Esophageal cancers account for majority of synchronous or metachronous head and neck cancers. This study examined the risk of esophageal cancer following percutaneous endoscopic gastrostomy (PEG) in head and neck cancer patients using the Taiwan National Health Insurance Research Database. From 1997 to 2010, we identified and analyzed 1851 PEG patients and 3702 sex-, age-, and index date-matched controls. After adjusting for esophagitis, esophagus stricture, esophageal reflux, and primary sites, the PEG cohort had a higher adjusted hazard ratio (2...
March 2016: Medicine (Baltimore)
Maryam Amizadeh, Ayeh Shamsadini, Aliakbar Arabzadeh, Seyedbehzad Jazayeri
Helicobacter pylori is a gram-negative bacillus causing benign and malignant gastric diseases such as gastroesophageal reflux (GER). In larynx, H. pylori causes chronic inflammation and mucosal destruction that may lead to malignant changes. Although, H. pylori poses several virulence factors, cagA is probably the main factor in this regard. To evaluate the role of cagA gene in laryngeal squamous cell carcinoma (LSCC), a case-control study was conducted on patients with laryngeal complaints during 2010-2012...
March 2015: Indian Journal of Otolaryngology and Head and Neck Surgery
Ziang Cao, Jiahao Zheng, Xiaozhe Qian, Zhiyong Sun
OBJECTIVE: To explore the methods and means of surgical treatment for cervical esophageal cancer in order to get the best efficacy. METHODS: Retrospective investigation and analysis were carried out in 137 patients with cervical esophageal cancer undergoing operation in our hospital from January 2005 to December 2013. According to lesion locations, these cases were divided into two groups: larynx preservation group(Group A) and laryngectomy group(Group B). Surgery options of Group A included inversion esophagectomy without thoracotomy, three-incision esophagectomy, end to end anastomosis of cervical esophagus after local resection...
September 2014: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Sang-Hyuk Lee, Tina Samuels, Jonathan M Bock, Joel H Blumin, Nikki Johnston
OBJECTIVES/HYPOTHESIS: Laryngopharyngeal reflux (LPR) has been implicated as a promoter of laryngeal cancer. Within the larynx, the posterior commissure (PC) is the region that usually comes into direct contact with refluxed materials. Specific laryngeal cell lines useful for in vitro studies are not widely available, and noncancer-derived PC laryngeal cell line has not yet been described. STUDY DESIGN: Experimental study. METHODS: Specimens of squamous epithelium from the PC of the larynx were collected from patients without a history or evidence of laryngeal inflammatory or neoplastic diseases...
February 2015: Laryngoscope
David O Francis, Michael F Vaezi
Although laryngopharyngeal reflux, also known as extraesophageal reflux (EER), was codified more than 25 years ago, it has not been characterized fully. There is no sensitive and specific diagnostic test, and its symptoms often are nonspecific and overlap with those of other conditions commonly seen in primary care and specialist practices. Otolaryngologists have an important role in the evaluation and management of these patients--they must investigate persistent reflux-attributed symptoms by direct visualization of the upper airway and larynx, and, in some circumstances, the esophagus...
September 2015: Clinical Gastroenterology and Hepatology
Duo Zhang, Jian Zhou, Bin Chen, Liang Zhou, Lei Tao
CONCLUSION: The meta-analysis supported the proposition that the prevalence of gastroesophageal reflux disease (GERD) was associated with laryngeal cancer, particularly in the hospital-based control group and diagnosed by esophagogastroduodenoscopy (EGD) or esophageal pH monitoring. However, no significant association was found between GERD and pharyngeal carcinoma. OBJECTIVES: A number of studies have been conducted to investigate the relationship between gastroesophageal reflux and laryngeal or pharyngeal carcinoma...
October 2014: Acta Oto-laryngologica
Payman Dabirmoghaddam, Amin Amali, Maziar Motiee Langroudi, Mohammad Reza Samavati Fard, Mona Hejazi, Masoud Sharifian Razavi
Laryngopharyngeal reflux (LPR) is a variant of gastroesophageal reflux disease (GERD) in which the stomach contents go up into the pharynx and then down into the larynx. LPR causes a wide spectrum of manifestations mainly related to the upper and the lower respiratory system such as laryngitis, asthma, chronic obstructive pulmonary disease, cough, hoarseness, postnasal drip disease, sinusitis, otitis media, recurrent pneumonia, laryngeal cancer and etc. The object of this study was to examine the effect of N-acetyl Cysteine (NAC) with and without Omeprazole on laryngitis and LPR...
2013: Acta Medica Iranica
J Löhler, A O H Gerstner, F Bootz, L E Walther
For patients without symptoms and at risk, there is no established early detection program to discover carcinomas of the upper aerodigestive tract in the sense of secondary prevention. Such type of prevention seems even more desirable because the chances for a cure and the quality of life are strongly dependent on the stage of the tumor and the time of the initial diagnosis. Six hundred and eight patients without symptoms but at least one of the self-reported risk factors "smoking", "alcohol consumption" or "reflux" were examined with an endoscope or an optical microscope for pathological findings in the upper aerodigestive tract once a year...
May 2014: European Archives of Oto-rhino-laryngology
Scott M Langevin, Dominique S Michaud, Carmen J Marsit, Heather H Nelson, Ariel E Birnbaum, Melissa Eliot, Brock C Christensen, Michael D McClean, Karl T Kelsey
BACKGROUND: Gastric reflux can reach into the upper airway, inducing cellular damage in the epithelial lining. This condition is believed to be a risk factor for development of laryngopharyngeal squamous cell carcinoma (LPSCC), although the literature is conflicting. METHODS: To better clarify this relationship, we assessed the association of self-reported heartburn history and medication use among 631 patients with LPSCCs and 1234 control subjects (frequency-matched on age, gender, and town of residence) enrolled as part of a population-based case-control study of head and neck squamous cell carcinoma in the greater Boston area...
June 2013: Cancer Epidemiology, Biomarkers & Prevention
Nora Siupsinskiene, Vilma Jurgutaviciute, Inga Katutiene, Dainius Janciauskas, Saulius Vaitkus, Kęstutis Adamonis
Clinical studies have shown that Helicobacter pylori can be found not only in the mucosa of the stomach, but in the pharyngeal and laryngeal regions as well. The aim of this prospective case-control study was to identify H. pylori infection in the biopsy material from the larynx of the patients suffering from benign laryngeal diseases (vocal fold polyps, laryngitis) and laryngeal cancer and to investigate the possible relationships between the laryngeal H. pylori and patients' socio-demographic data and laryngopharyngeal reflux...
August 2013: European Archives of Oto-rhino-laryngology
Nikki Johnston, Justin C Yan, Craig R Hoekzema, Tina L Samuels, Gary D Stoner, Joel H Blumin, Jonathan M Bock
OBJECTIVE/HYPOTHESIS: Laryngopharyngeal reflux (LPR) is thought to be a significant risk factor for laryngeal squamous cell carcinoma (SCC), but causality has never been proven. It is accepted that chronic reflux into the esophagus can induce metaplastic changes in esophageal mucosa with subsequent increased risk of esophageal adenocarcinoma, but no similar associations have been established for LPR and laryngopharyngeal SCC. The objective of this study was to test the hypothesis that reflux of pepsin into the laryngopharynx can promote carcinogenesis...
June 2012: Laryngoscope
T V Macfarlane, G J Macfarlane, N S Thakker, S Benhamou, C Bouchardy, W Ahrens, H Pohlabeln, P Lagiou, A Lagiou, X Castellsague, A Agudo, A Slamova, J Plzak, F Merletti, L Richiardi, R Talamini, L Barzan, K Kjaerheim, C Canova, L Simonato, D I Conway, P A McKinney, P Thomson, P Sloan, A Znaor, C M Healy, B E McCartan, M Marron, P Brennan
BACKGROUND: The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn; for regurgitation; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer. METHODS: A multicentre (10 European countries) case-control study [Alcohol-Related CAncers and GEnetic susceptibility (ARCAGE) project]. RESULTS: There were 1779 cases of UADT cancer and 1993 controls...
April 2012: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Akbar Pirzadeh, Najmeh Doustmohammadian, Manochehr Khoshbaten, Sorayya Doustmohammadion
OBJECTIVE: To investigate the possible role of Helicobacter pylori as a cause of squamous cell carcinoma of larynx in a case-control study in an otolaryngology ward at an academic university. SUBJECTS AND METHODS: A total of 65 patients with laryngeal cancer and 65 matched cancer-free controls underwent esophagogastroduodenoscopy and biopsy of antral and body regions of the stomach for evaluation of Helicobacter pylori infection. RESULTS: The proportion of subjects with a positive rapid urease test for gastric infection was similar between the two groups (49...
2011: Asian Pacific Journal of Cancer Prevention: APJCP
K J Lorenz, L Grieser, T Ehrhart, H Maier
INTRODUCTION: We conducted a prospective study to assess the influence of supra-esophageal reflux on voice quality and quality of life in patients who had undergone laryngectomy and prosthetic voice rehabilitation. PATIENTS AND METHODS: We investigated 60 laryngectomised patients using 24-h dual-probe pH monitoring before and 6 months after oral anti-reflux treatment with proton pump inhibitors (PPIs). Quality of life was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ) C30...
February 2011: HNO
D Gregory Farwell, Catherine J Rees, Debbie A Mouadeb, Jacqueline Allen, Allen M Chen, Danny J Enepekides, Peter C Belafsky
OBJECTIVE: To determine the prevalence of esophageal pathology following treatment for primary head and neck cancer (HNCA). STUDY DESIGN: Case series with planned data collection. SETTING: Academic medical practice. SUBJECTS AND METHODS: Subjects comprised HNCA survivors. Esophagoscopy was prospectively performed on 100 patients at least three months after treatment for HNCA. Patient demographics including cancer stage, cancer treatment, use of reflux medications, symptoms surveys, and esophageal findings were prospectively determined...
September 2010: Otolaryngology—Head and Neck Surgery
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