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https://www.readbyqxmd.com/read/29793108/manganese-contamination-affects-the-motor-performance-of-wild-northern-quolls-dasyurus-hallucatus
#1
Ami Fadhillah Amir Abdul Nasir, Skye F Cameron, Amanda C Niehaus, Christofer J Clemente, Frank A von Hippel, Robbie S Wilson
Neuromotor deficits are an important sign of manganese (Mn) toxicity in humans and laboratory animals. However, the impacts of Mn exposure on the motor function of wild animals remains largely unknown. Here, we assessed the impact of chronic exposure to Mn from active mining operations on Groote Eylandt, Australia on the motor function of the semi-arboreal northern quoll (Dasyurus hallucatus), an endangered species. The three motor tests conducted-maximum sprint speed on a straight run, manoeuvrability around a corner, and motor control on a balance beam-showed that elevated Mn body burden did not diminish performance of these traits...
May 21, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29792884/pharmacological-inhibition-of-dna-methylation-attenuates-pressure-overload-induced-cardiac-hypertrophy-in-rats
#2
Justus Stenzig, Yvonne Schneeberger, Alexandra Löser, Barbara S Peters, Andreas Schaefer, Rong-Rong Zhao, Shi Ling Ng, Grit Höppner, Birgit Geertz, Marc N Hirt, Wilson Tan, Eleanor Wong, Hermann Reichenspurner, Roger S-Y Foo, Thomas Eschenhagen
BACKGROUND: Heart failure is associated with altered gene expression and DNA methylation. De novo DNA methylation is associated with gene silencing, but its role in cardiac pathology remains incompletely understood. We hypothesized that inhibition of DNA methyltransferases (DNMT) might prevent the deregulation of gene expression and the deterioration of cardiac function under pressure overload (PO). To test this hypothesis, we evaluated a DNMT inhibitor in PO in rats and analysed DNA methylation in cardiomyocytes...
May 21, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29792472/effects-of-exercise-on-experimentally-manipulated-craving-for-cannabis-a-preliminary-study
#3
Sandy D Wilson, R Lorraine Collins, Mark A Prince, Paula C Vincent
Cannabis is the most commonly used illicit drug in the United States, and craving for cannabis is related to cannabis use. Exercise has been demonstrated to reduce craving for substances. To examine the effects of exercise on cannabis craving, we conducted a 3-week within-subject crossover experiment. Young-adult men (n = 35) and women (n = 11), age 18-25 years (M = 20.76, SD = 1.68), who regularly (≥3 times per week) used cannabis participated in a cue exposure paradigm to stimulate craving. After each of three separate craving inductions, they completed a 10-min bout of exercise that varied in intensity (rest, moderate, vigorous)...
May 24, 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29792242/testing-a-stepped-care-model-for-binge-eating-disorder-a-two-step-randomized-controlled-trial
#4
Giorgio A Tasca, Diana Koszycki, Agostino Brugnera, Livia Chyurlia, Nicole Hammond, Kylie Francis, Kerri Ritchie, Iryna Ivanova, Genevieve Proulx, Brian Wilson, Julie Beaulac, Hany Bissada, Erin Beasley, Nancy Mcquaid, Renee Grenon, Benjamin Fortin-Langelier, Angelo Compare, Louise Balfour
BACKGROUND: A stepped care approach involves patients first receiving low-intensity treatment followed by higher intensity treatment. This two-step randomized controlled trial investigated the efficacy of a sequential stepped care approach for the psychological treatment of binge-eating disorder (BED). METHODS: In the first step, all participants with BED (n = 135) received unguided self-help (USH) based on a cognitive-behavioral therapy model. In the second step, participants who remained in the trial were randomized either to 16 weeks of group psychodynamic-interpersonal psychotherapy (GPIP) (n = 39) or to a no-treatment control condition (n = 46)...
May 24, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29791688/periodontal-clinical-evaluation-before-and-after-surgically-assisted-rapid-maxillary-expansion
#5
Michelle Sendyk, Wilson Roberto Sendyk, Débora Pallos, Letícia Cristina Cidreira Boaro, João Batista de Paiva, José Rino Neto
INTRODUCTION: The surgically assisted rapid maxillary expansion is a procedure that reduces the resistance of the sutures correcting the posterior crossbite in adults. OBJECTIVE: The aim of this study was to evaluate the periodontal status of 17 adults submitted to this procedure. METHODS: The clinical attachment level (CAL), gingival recession, attached gingiva and bleeding were evaluated in maxillary first premolars and molars, central and lateral incisors of right and left sides before surgery, 5 days and 6 months after...
January 2018: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/29791626/aging-and-quality-of-life-of-elderly-people-in-rural-areas
#6
Juliana Ladeira Garbaccio, Luís Antônio Batista Tonaco, Wilson Goulart Estêvão, Bárbara Jacome Barcelos
OBJECTIVE: To evaluate the quality of life and health of elderly in rural areas of Minas Gerais State's center-west. METHOD: Cross-sectional study, in four municipalities of Minas Gerais State, by interviewing elderly people. Associations between socio-demographic and quality of life variables were tested, separated into "satisfactory"/"unsatisfactory" with values from the median of positive answers. It was used the chi-square test, Fisher's test and regression...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29791564/morphology-and-morphometry-of-upland-lakes-over-lateritic-crust-serra-dos-caraj%C3%A3-s-southeastern-amazon-region
#7
Marcio S DA Silva, José T F Guimarães, Pedro W M Souza Filho, Wilson Nascimento Júnior, Prafulla K Sahoo, Francisco R DA Costa, Renato O Silva Júnior, Tarcísio M Rodrigues, Marlene F DA Costa
High-resolution satellite images, digital elevation models, bathymetric and sedimentological surveys coupled with statistical analysis were used to understand the physical environment and discuss their influence on water quality of the five upland lakes of Serra Sul dos Carajás, southeast Amazonia. The lakes have mid-altitude ranges (elevation), very small (catchment) and shallow to very shallow (central basins). Based on the length, area and volume, Violão and TI (Três Irmãs)-3 lakes may present large vertical movements of the water due to wind action and weakly stratified waters...
May 17, 2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29791422/prevalence-of-non-a-to-e-hepatitis-in-mumbai-india
#8
Nishtha Nagral, Vrunda Joshi, Karan Baria, Pathik Parikh, Aabha Nagral, Jayanthi Shastri, Chandrakant Pawar
INTRODUCTION: Acute viral hepatitis is a common problem in India. World wide data shows that 5 to 20 percent of this is caused by non A-E hepatitis. There is no data in India regarding non A-E hepatitis. We carried out this study to evaluate the epidemiology, clinical features, risk factors and outcome of non A-E hepatitis. MATERIAL AND METHODS: In this single centre study, we evaluated all patients admitted with features of acute viral hepatitis at our hospital between the period of February to July 2015...
January 2018: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29791380/polarization-sensitive-laser-feedback-interferometry-for-specular-reflection-removal
#9
Alireza Mowla, Benjamin Wensheng Du, Thomas Taimre, Karl Bertling, Stephen Wilson, Aleksandar D Rakić
Specular reflection from the surface of targets or prepared specimens represents a significant problem in optical microscopy and related optical imaging techniques as usually the surface reflection does not contribute to the desired signal. Solutions exist for many of these imaging techniques; however, remedial techniques for imaging based on laser feedback interferometry (LFI) are absent. We propose a reflection cancellation technique based on crossed-polarization filtering that is tailored for a typical LFI configuration...
May 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791245/pi-3-5-p-2-controls-vacuole-potassium-transport-to-support-cellular-osmoregulation
#10
Zachary N Wilson, Amber L Scott, Robin D Dowell, Greg Odorizzi
Lysosomes are dynamic organelles with critical roles in cellular physiology. The lysosomal signaling lipid phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2 ) is a key regulator that has been implicated to control lysosome ion homeostasis, but the scope of ion transporters targeted by PI(3,5)P2 and the purpose of this regulation is not well understood. Through an unbiased screen in Saccharomyces cerevisiae, we identified loss-of-function mutations in the vacuolar H+ -ATPase (V-ATPase) and in Vnx1, a vacuolar monovalent cation/proton antiporter, as suppressor mutations that relieve the growth defects and osmotic swelling of vacuoles (lysosomes) in yeast lacking PI(3,5)P2 ...
May 23, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29790268/ask-me-children-s-experiences-of-pain-explored-using-the-draw-write-and-tell-method
#11
Nicole Pope, Mary Tallon, Gavin Leslie, Sally Wilson
PURPOSE: Pain management within emergency departments (ED) remains challenging. Given that unrelieved pain in children is linked to a number of negative physiological and psychological consequences, optimal management of children's pain is paramount. Many studies exploring children's pain have adopted quantitative methods or sought the perspectives of adults. Compared to adults, studies examining children's views on pain and pain management are limited. This study aimed to explore children's pain experiences, their perception of pain management and expectations of the role of the nurse...
May 23, 2018: Journal for Specialists in Pediatric Nursing: JSPN
https://www.readbyqxmd.com/read/29790246/a-review-of-predation-as-a-limiting-factor-for-bird-populations-in-mesopredator-rich-landscapes-a-case-study-of-the-uk
#12
Staffan Roos, Jennifer Smart, David W Gibbons, Jeremy D Wilson
The impact of increasing vertebrate predator numbers on bird populations is widely debated among the general public, game managers and conservationists across Europe. However, there are few systematic reviews of whether predation limits the population sizes of European bird species. Views on the impacts of predation are particularly polarised in the UK, probably because the UK has a globally exceptional culture of intensive, high-yield gamebird management where predator removal is the norm. In addition, most apex predators have been exterminated or much depleted in numbers, contributing to a widely held perception that the UK has high numbers of mesopredators...
May 22, 2018: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/29790239/ocean-warming-has-a-greater-effect-than-acidification-on-the-early-life-history-development-and-swimming-performance-of-a-large-circumglobal-pelagic-fish
#13
Sue-Ann Watson, Bridie J M Allan, David E McQueen, Simon Nicol, Darren M Parsons, Stephen M J Pether, Stephen Pope, Alvin N Setiawan, Neville Smith, Carly Wilson, Philip L Munday
Ocean warming and acidification are serious threats to marine life; however, their individual and combined effects on large pelagic and predatory fishes are poorly understood. We determined the effects of projected future temperature and carbon dioxide (CO2 ) levels on survival, growth, morphological development and swimming performance on the early life stages of a large circumglobal pelagic fish, the yellowtail kingfish Seriola lalandi. Eggs, larvae and juveniles were reared in cross-factored treatments of temperature (21 and 25°C) and pCO2 (500 and 985 μatm) from fertilisation to 25 days post hatching (dph)...
May 22, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29790150/the-emerging-role-of-awake-videolaryngoscopy-in-airway-management
#14
EDITORIAL
W M Wilson, A F Smith
No abstract text is available yet for this article.
May 23, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29790039/intimate-partner-violence-and-women-with-severe-mental-illnesses-needs-and-challenges-from-the-perspectives-of-behavioral-health-and-domestic-violence-service-providers
#15
Tonya B Van Deinse, Amy Blank Wilson, Rebecca J Macy, Gary S Cuddeback
Women with severe mental illnesses face high rates of violence victimization, yet little is understood about the unique needs and challenges these women present to the domestic violence and behavioral health agencies that serve them. To help address this knowledge gap, focus groups were conducted with 28 staff members from local behavioral health and domestic violence service agencies. Results from this exploratory study suggest that women with severe mental illnesses who experience intimate partner violence face additional challenges that exacerbate behavioral health and domestic violence issues and put these women at greater risk for continued victimization...
May 22, 2018: Journal of Behavioral Health Services & Research
https://www.readbyqxmd.com/read/29789423/atp-binding-cassette-member-b5-abcb5-promotes-tumor-cell-invasiveness-in-human-colorectal-cancer
#16
Qin Guo, Tanja Grimmig, Gabriel Gonzalez, Anita Giobbie-Hurder, Gretchen Berg, Nolan Carr, Brian J Wilson, Pallavi Banerjee, Jie Ma, Jason S Gold, Bisweswar Nandi, Qin Huang, Ana Maria Waaga-Gasser, Christine G Lian, George F Murphy, Markus H Frank, Martin Gasser, Natasha Y Frank
ATP-binding cassette member B5 (ABCB5) mediates multidrug resistance (MDR) in diverse malignancies and confers clinically relevant 5-fluorouracil resistance to CD133-expressing cancer stem cells (CSCs) in human colorectal cancer (CRC). Because of its recently identified roles in normal stem cell maintenance, we hypothesized that ABCB5 might also serve MDR-independent functions in CRC. Here, in a prospective clinical study of 142 CRC patients, we found that ABCB5 mRNA transcripts previously reported not to be significantly expressed in healthy peripheral blood mononuclear cells are significantly enriched in patient peripheral blood specimens compared with non-CRC controls and correlate with CRC disease progression...
May 22, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29788783/a-mixed-methods-approach-to-understanding-the-palliative-needs-of-parkinson-s-patients
#17
Lindsay P Prizer, Jennifer L Gay, Mark G Wilson, Kerstin G Emerson, Anne P Glass, Janis M Miyasaki, Molly M Perkins
Parkinson's disease (PD) is the second-most common age-related neurodegenerative disorder. Despite recommendations for a palliative approach, little is known about what palliative needs are unmet by standard care. This study aims to (a) identify palliative needs of PD patients, (b) determine the relationship between palliative needs and health-related quality of life (HRQoL), and (c) probe into factors affecting HRQoL. PD patients and neurologists were recruited for a survey on palliative need; a subset of patients was interviewed...
May 1, 2018: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29788397/polyspecific-intravenous-immunoglobulin-in-clindamycin-treated-patients-with-streptococcal-toxic-shock-syndrome-a-systematic-review-and-meta-analysis
#18
Tom Parks, Clare Wilson, Nigel Curtis, Anna Norrby-Teglund, Shiranee Sriskandan
We evaluated the effect of adjunctive intravenous immunoglobulin (IVIG) on mortality in clindamycin-treated streptococcal toxic shock syndrome patients using a meta-analysis. In association with IVIG, mortality fell from 33.7% to 15.7% (risk ratio 0.46, 95% confidence intervals 0.26-0.83, p=0.010) with remarkable consistency across the single randomised and four non-randomised studies.
May 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29788270/determinants-of-hearing-aid-use-among-older-americans-with-hearing-loss
#19
Michael M McKee, HwaJung Choi, Shelby Wilson, Melissa J DeJonckheere, Philip Zazove, Helen Levy
Background and Objectives: Hearing loss (HL) is common among older adults and is associated with significant psychosocial, cognitive, and physical sequelae. Hearing aids (HA) can help, but not all individuals with HL use them. This study examines how social determinants may impact HA use. Research Design and Methods: We conducted an explanatory sequential mixed methods study involving a secondary analysis of a nationally representative data set, the Health and Retirement Study (HRS; n = 35,572)...
May 21, 2018: Gerontologist
https://www.readbyqxmd.com/read/29788230/tumor-infiltrating-lymphocytes-in-patients-receiving-trastuzumab-pertuzumab-based-chemotherapy-a-tryphaena-substudy
#20
Michail Ignatiadis, Gert Van den Eynden, Salgado Roberto, Marco Fornili, Yacine Bareche, Christine Desmedt, Françoise Rothé, Marion Maetens, David Venet, Esther Holgado, Virginia McNally, Astrid Kiermaier, Heidi M Savage, Timothy R Wilson, Javier Cortes, Andreas Schneeweiss, Karen Willard-Gallo, Elia Biganzoli, Christos Sotiriou
Background: There is an urgent requirement to identify biomarkers to tailor treatment in human epidermal growth factor receptor 2 (HER2)-amplified early breast cancer treated with trastuzumab/pertuzumab-based chemotherapy. Methods: Among the 225 patients randomly assigned to trastuzumab/pertuzumab concurrently or sequentially with an anthracycline-containing regimen or concurrently with an anthracycline-free regimen in the Tryphaena trial, we determined the percentage of tumor-infiltrating lymphocytes (TILs) at baseline in 213 patients, of which 126 demonstrated a pathological complete response (pCR; ypT0/is ypN0), with 28 demonstrating event-free survival (EFS) events...
May 18, 2018: Journal of the National Cancer Institute
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