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https://www.readbyqxmd.com/read/28700272/accuracy-of-a-fourth-generation-subcutaneous-continuous-glucose-sensor
#1
Mark P Christiansen, Satish K Garg, Ronald Brazg, Bruce W Bode, Timothy S Bailey, Robert H Slover, Ashley Sullivan, Suiying Huang, John Shin, Scott W Lee, Francine R Kaufman
BACKGROUND: This study evaluated the accuracy and performance of a fourth-generation subcutaneous glucose sensor (Guardian(™) Sensor 3) in the abdomen and arm. METHODS: Eighty-eight subjects (14-75 years of age, mean ± standard deviation [SD] of 42.0 ± 19.1 years) with type 1 or type 2 diabetes participated in the study. Subjects wore two sensors in the abdomen that were paired with either a MiniMed(™) 640G insulin pump, or an iPhone(®) or iPod(®) touch(®) running a glucose monitoring mobile application (Guardian Connect system) and a third sensor in the arm, which was connected to a glucose sensor recorder (GSR)...
July 12, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28624734/indirect-influence-of-eutrophication-on-air-water-exchange-fluxes-sinking-fluxes-and-occurrence-of-polycyclic-aromatic-hydrocarbons
#2
Yuqiang Tao, Jing Yu, Guoliang Lei, Bin Xue, Fengju Zhang, Shuchun Yao
How eutrophication affects biogeochemical processes of hydrophobic organic contaminants (HOCs) in aquatic environments is a pending challenge. Although the direct influence of eutrophication on biogeochemical processes of HOCs in waters has been well addressed, the indirect influence of eutrophication on biogeochemical processes of HOCs remains largely unknown. Here we take the large shallow eutrophic Lake Taihu in China and polycyclic aromatic hydrocarbons (PAHs) as examples to provide novel knowledge on the indirect influence of eutrophication on air - water exchange fluxes, sinking fluxes, and occurrence of HOCs...
June 10, 2017: Water Research
https://www.readbyqxmd.com/read/28570899/characterisation-and-potential-source-identification-of-polycyclic-aromatic-hydrocarbons-in-atmospheric-particles-pm10-from-urban-and-suburban-residential-areas-in-shiraz-iran
#3
Samaneh Shahsavani, Mohammad Hoseini, Mansooreh Dehghani, Mohammad Fararouei
Polycyclic aromatic hydrocarbons (PAHs) are a generally hazardous class of organic compounds that are identified as toxic, carcinogenic, mutagenic, and teratogenic, and are considered to be a concern for human health because of their potential for causing adverse health effects. The present study aims to determine the atmospheric concentration and potential sources of particulate-bound PAHs in urban and suburban atmospheric particulate matter (PM10) in Shiraz, Iran. Ambient air samples were collected from urban and suburban areas using a SKC sampling pump equipped with a size-selective air intake during the spring of 2015...
May 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/28558433/testing-the-usefulness-of-222-rn-to-complement-conventional-hydrochemical-data-to-trace-groundwater-provenance-in-complex-multi-layered-aquifers-application-to-the-%C3%A3-beda-aquifer-system-ja%C3%A3-n-se-spain
#4
L Ortega, M Manzano, J Rodríguez-Arévalo
The Úbeda aquifer system is a multi-layered aquifer intensively exploited for irrigation. It covers 1100km(2) and consists of piled up sedimentary aquifer and aquitard layers from Triassic sandstones and clays at the bottom, to Jurassic carbonates (main exploited layer) in the middle, and Miocene sandstones and marls at the top. Flow network modification by intense exploitation and the existence of deep faults favour vertical mixing of waters from different layers and with distinct chemical composition. This induces quality loss and fosters risk of quantity restrictions...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28488188/spring-bud-growth-depends-on-sugar-delivery-by-xylem-and-water-recirculation-by-phloem-m%C3%A3-nch-flow-in-juglans-regia
#5
Aude Tixier, Or Sperling, Jessica Orozco, Bruce Lampinen, Adele Amico Roxas, Sebastian Saa, J Mason Earles, Maciej A Zwieniecki
During spring, bud growth relies on long-distance transport of remotely stored carbohydrates. A new hypothesis suggests this transport is achieved by the interplay of xylem and phloem. During the spring, carbohydrate demand of developing buds often exceeds locally available storage, thus requiring the translocation of sugars from distant locations like limbs, stems and roots. Both the phloem and xylem have the capacity for such long-distance transport, but their functional contribution is unclear. To address this ambiguity, the spatial and temporal dynamics of carbohydrate availability in extension shoots of Juglans regia L...
May 9, 2017: Planta
https://www.readbyqxmd.com/read/28460755/-snorkel-lice-barrier-technology-reduced-two-co-occurring-parasites-the-salmon-louse-lepeophtheirus-salmonis-and-the-amoebic-gill-disease-causing-agent-neoparamoeba-perurans-in-commercial-salmon-sea-cages
#6
D W Wright, L H Stien, T Dempster, T Vågseth, V Nola, J-E Fosseidengen, F Oppedal
Diverse chemical-free parasite controls are gaining status in Atlantic salmon sea-cage farming. Yet, the intricacies of their use at commercial scale, including effects on co-occurring parasites, are seldom reported. A new salmon lice prevention method involves installing a deep net roof and 'snorkel' lice barrier in cages to shelter salmon from free-living infective larvae which concentrate at shallow depths, and allows salmon to jump and re- inflate their buoyancy-regulating swim bladder by swallowing air...
May 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28452746/development-of-optical-choppers-for-time-resolved-measurements-at-soft-x-ray-synchrotron-radiation-beamlines
#7
Hitoshi Osawa, Takuo Ohkochi, Masami Fujisawa, Shigeru Kimura, Toyohiko Kinoshita
Two types of optical choppers for time-resolved measurements at synchrotron radiation soft X-ray beamlines have been developed. One type uses an air-spindle-type rotation mechanism with a two-stage differential pumping system to maintain the ultra-high vacuum of the X-ray beamline, and the other uses a magnetic bearing. Both can be installed at the soft X-ray beamlines at SPring-8, greatly improving the accessibility of pump-and-probe spectroscopy. The combination of X-ray chopper and pump-and-probe photoemission electron microscope at SPring-8 provides drastic improvements in signal-to-noise ratio and resolution compared with techniques using high-voltage gating of channel plate detectors...
May 1, 2017: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/28221823/evaluation-of-a-predictive-low-glucose-management-system-in-clinic
#8
Bruce A Buckingham, Timothy S Bailey, Mark Christiansen, Satish Garg, Stuart Weinzimer, Bruce Bode, Stacey M Anderson, Ronald Brazg, Trang T Ly, Francine R Kaufman
BACKGROUND: Predictions based on continuous glucose monitoring (CGM) data are the basis for automatic suspension and resumption of insulin delivery by a predictive low-glucose management feature termed "suspend before low," which is part of the Medtronic MiniMed(®) 640G combined insulin pump and CGM system. This study assessed the safety and performance characteristics of the system in an in-clinic setting at eight sites. MATERIALS AND METHODS: In-clinic standardized increases in basal insulin delivery rates were used to induce nocturnal hypoglycemia in subjects (14-75 years) with type 1 diabetes wearing the MiniMed 640G system...
May 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28125113/a-dissipative-particle-dynamics-study-of-a-flexible-filament-in-confined-shear-flow
#9
D Vijay Anand, B S V Patnaik, Srikanth Vedantam
In this paper, we investigate the dynamics of a tethered flexible filament due to fluid flow inside a microchannel. We use the finite sized dissipative particle dynamics (FDPD) approach to model this problem. The flexible filament is modeled as a bead-spring system with both extensional and flexural rigidity. The influence of flow rate and bending stiffness on the filament dynamics is studied in terms of the different conformational modes obtained. The competing effects of the hydrodynamic force and elastic force in the presence of Brownian thermal effects of comparable order influence the mode shapes of the filament...
February 15, 2017: Soft Matter
https://www.readbyqxmd.com/read/28115676/the-effectiveness-of-sanitary-inspections-as-a-risk-assessment-tool-for-thermotolerant-coliform-bacteria-contamination-of-rural-drinking-water-a-review-of-data-from-west-bengal-india
#10
Christian Snoad, Corey Nagel, Animesh Bhattacharya, Evan Thomas
AbstractThe use of sanitary inspections combined with periodic water quality testing has been recommended in some cases as screening tools for fecal contamination. We conducted sanitary inspections and tested for thermotolerant coliforms (TTCs), a fecal indicator bacteria, among 7,317 unique water sources in West Bengal, India. Our results indicate that the sanitary inspection score has poor ability to identify TTC-contaminated sources. Among deep and shallow hand pumps, the area under curve (AUC) for prediction of TTC > 0 was 0...
April 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28112659/the-response-of-phytoplankton-and-microlayer-adapted-bacteria-to-monolayer-application-in-a-humic-eutrophic-irrigation-dam
#11
P Pittaway, V Matveev
Repeat applications of artificial monolayers to farm irrigation dams to reduce evaporative loss may adversely affect water quality by enhancing populations of microlayer-adapted bacteria and blue-green algae. The microlayer, subsurface and water column of a 16 ha dam were monitored every two weeks for 18 months, to benchmark the seasonal dynamics of phytoplankton and microlayer-adapted bacteria prior to monolayer application. Results for Secchi depth, total P, total N, chlorophyll a, phytobiovolume and UV254 absorbance, characterise Logan's Dam as humic and hypereutrophic...
January 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28025146/attachment-of-a-molecular-spring-restores-drug-stimulated-atpase-activity-to-p-glycoprotein-lacking-both-q-loop-glutamines
#12
Tip W Loo, David M Clarke
P-glycoprotein (P-gp) is an ABC (ATP-Binding Cassette) drug pump that is clinically important because it confers multidrug resistance. Drugs bind at the interface between the transmembrane domains to activate ATPase activity at the two nucleotide-binding domains (NBDs). Drug transport involves ATP-dependent conformational changes between inward- (open, NBDs far apart) and outward-facing (closed, NBDs close together) conformations. Recently, it was reported that the conserved glutamines residues (Gln475 in NBD1 and Gln1118 in NBD2) in the Q loops of P-gp when mutated to alanine completely inhibited the drug-stimulated ATPase activity...
January 29, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27922000/membrane-pyrophosphatases-from-thermotoga-maritima-and-vigna-radiata-suggest-a-conserved-coupling-mechanism
#13
Kun-Mou Li, Craig Wilkinson, Juho Kellosalo, Jia-Yin Tsai, Tommi Kajander, Lars J C Jeuken, Yuh-Ju Sun, Adrian Goldman
Membrane-bound pyrophosphatases (M-PPases), which couple proton/sodium ion transport to pyrophosphate synthesis/hydrolysis, are important in abiotic stress resistance and in the infectivity of protozoan parasites. Here, three M-PPase structures in different catalytic states show that closure of the substrate-binding pocket by helices 5-6 affects helix 13 in the dimer interface and causes helix 12 to move down. This springs a 'molecular mousetrap', repositioning a conserved aspartate and activating the nucleophilic water...
December 6, 2016: Nature Communications
https://www.readbyqxmd.com/read/27911518/stable-optical-trap-from-a-single-optical-field-utilizing-birefringence
#14
Robinjeet Singh, Garrett D Cole, Jonathan Cripe, Thomas Corbitt
We report a stable double optical spring effect in an optical cavity pumped with a single optical field that arises as a result of birefringence. One end of the cavity is formed by a multilayer Al_{0.92}Ga_{0.08}As/GaAs stack supported by a microfabricated cantilever with a natural mode frequency of 274 Hz. The optical spring shifts the resonance to 21 kHz, corresponding to a suppression of low frequency vibrations by a factor of about 5 000. The stable nature of the optical trap allows the cavity to be operated without any external feedback and with only a single optical field incident...
November 18, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27761525/a-simple-check-valve-for-microfluidic-point-of-care-diagnostics
#15
C S Ball, R F Renzi, A Priye, R J Meagher
Check valves are often essential components in microfluidic devices, enabling automated sample processing for diagnostics at the point of care. However, there is an unmet need for a check valve design that is compatible with rigid thermoplastic devices during all stages of development-from initial prototyping with a laser cutter to final production with injection molding. Here, we present simple designs for a passive, normally closed check valve that is manufactured from commonly available materials with a CO2 laser and readily integrated into prototype and production thermoplastic devices...
November 1, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27472753/radon-levels-measured-at-a-touristic-thermal-spa-resort-in-montagu-south-africa-and-associated-effective-doses
#16
R Botha, R T Newman, P P Maleka
Radon activity concentrations (in water and in air) were measured at 13 selected locations at the Avalon Springs thermal spa resort in Montagu (Western Cape, South Africa) to estimate the associated effective dose received by employees and visitors. A RAD-7 detector (DURRIDGE), based on alpha spectrometry, and electret detectors (E-PERM®Radelec) were used for these radon measurements. The primary source of radon was natural thermal waters from the hot spring, which were pumped to various locations on the resort, and consequently a range of radon in-water analyses were performed...
September 2016: Health Physics
https://www.readbyqxmd.com/read/27453137/seawater-intrusion-in-karstic-coastal-aquifers-current-challenges-and-future-scenarios-in-the-taranto-area-southern-italy
#17
Giovanna De Filippis, Laura Foglia, Mauro Giudici, Steffen Mehl, Stefano Margiotta, Sergio Luigi Negri
Mediterranean areas are characterized by complex hydrogeological systems, where management of freshwater resources, mostly stored in karstic, coastal aquifers, is necessary and requires the application of numerical tools to detect and prevent deterioration of groundwater, mostly caused by overexploitation. In the Taranto area (southern Italy), the deep, karstic aquifer is the only source of freshwater and satisfies the main human activities. Preserving quantity and quality of this system through management policies is so necessary and such task can be addressed through modeling tools which take into account human impacts and the effects of climate changes...
December 15, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27435145/safety-of-using-real-time-sensor-glucose-values-for-treatment-decisions-in-adolescents-with-poorly-controlled-type-1-diabetes-mellitus-a-pilot-study
#18
Larry A Fox, Emilie Balkman, Kim Englert, Jobayer Hossain, Nelly Mauras
BACKGROUND: This study explored the safety of using real-time sensor glucose (SG) data for treatment decisions in adolescents with poorly controlled type 1 diabetes. METHODS: Ten adolescents with type 1 diabetes, HbA1c ≥9% on insulin pumps were admitted to the clinical research center and a continuous glucose sensor was inserted. Plasma glucose was measured at least hourly using Yellow Springs Instrument's (YSI) glucose analyzer. Starting at dinner, SG rather than YSI was used for treatment decisions unless YSI was <70 mg/dL (<3...
June 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/27382075/autosyp-a-low-cost-low-power-syringe-pump-for-use-in-low-resource-settings
#19
Alexa Juarez, Kelley Maynard, Erica Skerrett, Elizabeth Molyneux, Rebecca Richards-Kortum, Queen Dube, Z Maria Oden
This article describes the design and evaluation of AutoSyP, a low-cost, low-power syringe pump intended to deliver intravenous (IV) infusions in low-resource hospitals. A constant-force spring within the device provides mechanical energy to depress the syringe plunger. As a result, the device can run on rechargeable battery power for 66 hours, a critical feature for low-resource settings where the power grid may be unreliable. The device is designed to be used with 5- to 60-mL syringes and can deliver fluids at flow rates ranging from 3 to 60 mL/hour...
October 5, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27340247/recruitment-into-a-pediatric-continuous-glucose-monitoring-rct
#20
Lisa K Volkening, Kaitlin C Gaffney, Michelle L Katz, Lori M Laffel
BACKGROUND: The purpose was to identify patient/family characteristics and recruitment process characteristics associated with the decision to participate in a 2-year continuous glucose monitoring (CGM) RCT for youth with type 1 diabetes and their families. METHOD: Study staff approached patients who were conditionally eligible according to medical record review or referred by a provider. We categorized families according to participation decision (agree vs decline) and timing of decision (day of approach vs later ["thinkers"])...
January 2017: Journal of Diabetes Science and Technology
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