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https://www.readbyqxmd.com/read/28221823/evaluation-of-a-predictive-low-glucose-management-system-in-clinic
#1
Bruce A Buckingham, Timothy S Bailey, Mark Christiansen, Satish Garg, Stuart Weinzimer, Bruce Bode, Stacey M Anderson, Ron Brazg, Trang Ly, Francine R Kaufman
BACKGROUND: Predictions based on continuous glucose monitoring (CGM) data are the basis for automatic suspension and resumption of insulin delivery by a predictive low-glucose management feature termed "suspend before low," which is part of the Medtronic MiniMed(®) 640G combined insulin pump and CGM system. This study assessed the safety and performance characteristics of the system in an in-clinic setting at eight sites. MATERIALS AND METHODS: In-clinic standardized increases in basal insulin delivery rates were used to induce nocturnal hypoglycemia in subjects (14-75 years) with type 1 diabetes wearing the MiniMed 640G system...
February 16, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28125113/a-dissipative-particle-dynamics-study-of-a-flexible-filament-in-confined-shear-flow
#2
D Vijay Anand, B S V Patnaik, Srikanth Vedantam
In this paper, we investigate the dynamics of a tethered flexible filament due to fluid flow inside a microchannel. We use the finite sized dissipative particle dynamics (FDPD) approach to model this problem. The flexible filament is modeled as a bead-spring system with both extensional and flexural rigidity. The influence of flow rate and bending stiffness on the filament dynamics is studied in terms of the different conformational modes obtained. The competing effects of the hydrodynamic force and elastic force in the presence of Brownian thermal effects of comparable order influence the mode shapes of the filament...
February 15, 2017: Soft Matter
https://www.readbyqxmd.com/read/28115676/the-effectiveness-of-sanitary-inspections-as-a-risk-assessment-tool-for-thermotolerant-coliform-bacteria-contamination-of-rural-drinking-water-a-review-of-data-from-west-bengal-india
#3
Christian Snoad, Corey Nagel, Animesh Bhattacharya, Evan Thomas
The use of sanitary inspections combined with periodic water quality testing has been recommended in some cases as screening tools for fecal contamination. We conducted sanitary inspections and tested for thermotolerant coliforms (TTCs), a fecal indicator bacteria, among 7,317 unique water sources in West Bengal, India. Our results indicate that the sanitary inspection score has poor ability to identify TTC-contaminated sources. Among deep and shallow hand pumps, the area under curve (AUC) for prediction of TTC > 0 was 0...
January 23, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28112659/the-response-of-phytoplankton-and-microlayer-adapted-bacteria-to-monolayer-application-in-a-humic-eutrophic-irrigation-dam
#4
P Pittaway, V Matveev
Repeat applications of artificial monolayers to farm irrigation dams to reduce evaporative loss may adversely affect water quality by enhancing populations of microlayer-adapted bacteria and blue-green algae. The microlayer, subsurface and water column of a 16 ha dam were monitored every two weeks for 18 months, to benchmark the seasonal dynamics of phytoplankton and microlayer-adapted bacteria prior to monolayer application. Results for Secchi depth, total P, total N, chlorophyll a, phytobiovolume and UV254 absorbance, characterise Logan's Dam as humic and hypereutrophic...
January 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28025146/attachment-of-a-molecular-spring-restores-drug-stimulated-atpase-activity-to-p-glycoprotein-lacking-both-q-loop-glutamines
#5
Tip W Loo, David M Clarke
P-glycoprotein (P-gp) is an ABC (ATP-Binding Cassette) drug pump that is clinically important because it confers multidrug resistance. Drugs bind at the interface between the transmembrane domains to activate ATPase activity at the two nucleotide-binding domains (NBDs). Drug transport involves ATP-dependent conformational changes between inward- (open, NBDs far apart) and outward-facing (closed, NBDs close together) conformations. Recently, it was reported that the conserved glutamines residues (Gln475 in NBD1 and Gln1118 in NBD2) in the Q loops of P-gp when mutated to alanine completely inhibited the drug-stimulated ATPase activity...
January 29, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27922000/membrane-pyrophosphatases-from-thermotoga-maritima-and-vigna-radiata-suggest-a-conserved-coupling-mechanism
#6
Kun-Mou Li, Craig Wilkinson, Juho Kellosalo, Jia-Yin Tsai, Tommi Kajander, Lars J C Jeuken, Yuh-Ju Sun, Adrian Goldman
Membrane-bound pyrophosphatases (M-PPases), which couple proton/sodium ion transport to pyrophosphate synthesis/hydrolysis, are important in abiotic stress resistance and in the infectivity of protozoan parasites. Here, three M-PPase structures in different catalytic states show that closure of the substrate-binding pocket by helices 5-6 affects helix 13 in the dimer interface and causes helix 12 to move down. This springs a 'molecular mousetrap', repositioning a conserved aspartate and activating the nucleophilic water...
December 6, 2016: Nature Communications
https://www.readbyqxmd.com/read/27911518/stable-optical-trap-from-a-single-optical-field-utilizing-birefringence
#7
Robinjeet Singh, Garrett D Cole, Jonathan Cripe, Thomas Corbitt
We report a stable double optical spring effect in an optical cavity pumped with a single optical field that arises as a result of birefringence. One end of the cavity is formed by a multilayer Al_{0.92}Ga_{0.08}As/GaAs stack supported by a microfabricated cantilever with a natural mode frequency of 274 Hz. The optical spring shifts the resonance to 21 kHz, corresponding to a suppression of low frequency vibrations by a factor of about 5 000. The stable nature of the optical trap allows the cavity to be operated without any external feedback and with only a single optical field incident...
November 18, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27761525/a-simple-check-valve-for-microfluidic-point-of-care-diagnostics
#8
C S Ball, R F Renzi, A Priye, R J Meagher
Check valves are often essential components in microfluidic devices, enabling automated sample processing for diagnostics at the point of care. However, there is an unmet need for a check valve design that is compatible with rigid thermoplastic devices during all stages of development-from initial prototyping with a laser cutter to final production with injection molding. Here, we present simple designs for a passive, normally closed check valve that is manufactured from commonly available materials with a CO2 laser and readily integrated into prototype and production thermoplastic devices...
November 1, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27472753/radon-levels-measured-at-a-touristic-thermal-spa-resort-in-montagu-south-africa-and-associated-effective-doses
#9
R Botha, R T Newman, P P Maleka
Radon activity concentrations (in water and in air) were measured at 13 selected locations at the Avalon Springs thermal spa resort in Montagu (Western Cape, South Africa) to estimate the associated effective dose received by employees and visitors. A RAD-7 detector (DURRIDGE), based on alpha spectrometry, and electret detectors (E-PERM®Radelec) were used for these radon measurements. The primary source of radon was natural thermal waters from the hot spring, which were pumped to various locations on the resort, and consequently a range of radon in-water analyses were performed...
September 2016: Health Physics
https://www.readbyqxmd.com/read/27453137/seawater-intrusion-in-karstic-coastal-aquifers-current-challenges-and-future-scenarios-in-the-taranto-area-southern-italy
#10
Giovanna De Filippis, Laura Foglia, Mauro Giudici, Steffen Mehl, Stefano Margiotta, Sergio Luigi Negri
Mediterranean areas are characterized by complex hydrogeological systems, where management of freshwater resources, mostly stored in karstic, coastal aquifers, is necessary and requires the application of numerical tools to detect and prevent deterioration of groundwater, mostly caused by overexploitation. In the Taranto area (southern Italy), the deep, karstic aquifer is the only source of freshwater and satisfies the main human activities. Preserving quantity and quality of this system through management policies is so necessary and such task can be addressed through modeling tools which take into account human impacts and the effects of climate changes...
December 15, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27435145/safety-of-using-real-time-sensor-glucose-values-for-treatment-decisions-in-adolescents-with-poorly-controlled-type-1-diabetes-mellitus-a-pilot-study
#11
Larry A Fox, Emilie Balkman, Kim Englert, Jobayer Hossain, Nelly Mauras
BACKGROUND: This study explored the safety of using real-time sensor glucose (SG) data for treatment decisions in adolescents with poorly controlled type 1 diabetes. METHODS: Ten adolescents with type 1 diabetes, HbA1c ≥9% on insulin pumps were admitted to the clinical research center and a continuous glucose sensor was inserted. Plasma glucose was measured at least hourly using Yellow Springs Instrument's (YSI) glucose analyzer. Starting at dinner, SG rather than YSI was used for treatment decisions unless YSI was <70 mg/dL (<3...
July 20, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27382075/autosyp-a-low-cost-low-power-syringe-pump-for-use-in-low-resource-settings
#12
Alexa Juarez, Kelley Maynard, Erica Skerrett, Elizabeth Molyneux, Rebecca Richards-Kortum, Queen Dube, Z Maria Oden
This article describes the design and evaluation of AutoSyP, a low-cost, low-power syringe pump intended to deliver intravenous (IV) infusions in low-resource hospitals. A constant-force spring within the device provides mechanical energy to depress the syringe plunger. As a result, the device can run on rechargeable battery power for 66 hours, a critical feature for low-resource settings where the power grid may be unreliable. The device is designed to be used with 5- to 60-mL syringes and can deliver fluids at flow rates ranging from 3 to 60 mL/hour...
July 5, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27340247/recruitment-into-a-pediatric-continuous-glucose-monitoring-rct-patient-and-recruitment-process-characteristics-associated-with-decision-to-participate
#13
Lisa K Volkening, Kaitlin C Gaffney, Michelle L Katz, Lori M Laffel
BACKGROUND: The purpose was to identify patient/family characteristics and recruitment process characteristics associated with the decision to participate in a 2-year continuous glucose monitoring (CGM) RCT for youth with type 1 diabetes and their families. METHOD: Study staff approached patients who were conditionally eligible according to medical record review or referred by a provider. We categorized families according to participation decision (agree vs decline) and timing of decision (day of approach vs later ["thinkers"])...
June 22, 2016: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/27270483/sources-and-seasonal-variation-of-coliform-bacteria-abundance-in-groundwater-around-the-slopes-of-mount-meru-arusha-tanzania
#14
Eliapenda Elisante, Alfred N N Muzuka
The quality of the groundwater along the slopes of Mount Meru, Tanzania, is poorly understood. Water access and sanitation practices may pose health risks to communities. This study was undertaken to assess the sources, abundance and seasonal variation of coliform bacteria in groundwater and factors contributing to such variations along slopes of Mount Meru, Tanzania. Water samples collected from 67 randomly selected water sources (springs, shallow wells which ranged from 4 to 35 m deep and Boreholes above 40 m deep) during dry and wet seasons were analysed for total coliform (TC), faecal coliform (FC), Escherichia coli (E...
July 2016: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27075311/health-risk-assessment-of-heavy-metals-and-bacterial-contamination-in-drinking-water-sources-a-case-study-of-malakand-agency-pakistan
#15
Javed Nawab, Sardar Khan, Sharafat Ali, Hassan Sher, Ziaur Rahman, Kifayatullah Khan, Jianfeng Tang, Aziz Ahmad
Human beings are frequently exposed to pathogens and heavy metals through ingestion of contaminated drinking water throughout the world particularly in developing countries. The present study aimed to assess the quality of water used for drinking purposes in Malakand Agency, Pakistan. Water samples were collected from different sources (dug wells, bore wells, tube wells, springs, and hand pumps) and analyzed for different physico-chemical parameters and bacterial pathogens (fecal coliform bacteria) using standard methods, while heavy metals were analyzed using atomic absorption spectrophotometry (AAS-PEA-700)...
May 2016: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27020173/the-dissolved-uranium-concentration-and-234-u-238-u-activity-ratio-in-groundwaters-from-spas-of-southeastern-brazil
#16
Daniel Marcos Bonotto
This paper describes the natural radioactivity due to (238)U and (234)U in 75 water sources from spas located in 14 municipalities in São Paulo and Minas Gerais states, Brazil. These waters are extensively utilized for drinking in public places, bottling and bathing purposes, among other uses. The water samples were taken from springs and pumped tubular wells drilled into different aquifer systems in the Paraná and Southeastern Shield hydrogeological provinces. The measurements of alpha-emitting radionuclides were also accompanied by the monitoring of temperature, pH, Eh, electrical conductivity, dissolved gases (O2, CO2, H2S, radon, thoron) and major constituents...
January 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/26922791/response-of-branchial-na-k-atpase-to-changes-in-ambient-temperature-in-atlantic-cod-gadus-morhua-and-whiting-merlangius-merlangus
#17
Katharina Michael, Nils Koschnick, Hans-O Pörtner, Magnus Lucassen
The maintenance of ion and pH homeostasis despite changes in ambient temperature is crucial for ectothermic organisms. Thermal sensitivity of Na(+)/K(+) ATPase mRNA expression, protein expression and activity was determined in gills of North Sea cod (NC) and Northeastern Arctic cod (NEAC), acclimated for 6 weeks at 4 and 10 °C and compared to field samples of North Sea cod (sNC), acclimatized to early spring (4 °C) and summer (18 °C) conditions. The same analyses were conducted in gills of the confamiliar whiting, acclimated at 4 and 10 °C...
May 2016: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/26504246/tether-mutations-that-restore-function-and-suppress-pleiotropic-phenotypes-of-the-c-elegans-isp-1-qm150-rieske-iron-sulfur-protein
#18
Gholamali Jafari, Brian M Wasko, Ashley Tonge, Nathan Schurman, Cindy Dong, Zhongyu Li, Rebecca Peters, Ernst-Bernhard Kayser, Jason N Pitt, Phil G Morgan, Margaret M Sedensky, Antony R Crofts, Matt Kaeberlein
Mitochondria play an important role in numerous diseases as well as normative aging. Severe reduction in mitochondrial function contributes to childhood disorders such as Leigh Syndrome, whereas mild disruption can extend the lifespan of model organisms. The Caenorhabditis elegans isp-1 gene encodes the Rieske iron-sulfur protein subunit of cytochrome c oxidoreductase (complex III of the electron transport chain). The partial loss of function allele, isp-1(qm150), leads to several pleiotropic phenotypes. To better understand the molecular mechanisms of ISP-1 function, we sought to identify genetic suppressors of the delayed development of isp-1(qm150) animals...
November 10, 2015: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26488290/dynamic-behavior-of-reciprocating-plunger-pump-discharge-valve-based-on-fluid-structure-interaction-and-experimental-analysis
#19
Guorong Wang, Lin Zhong, Xia He, Zhongqing Lei, Gang Hu, Rong Li, Yunhai Wang
The influence of spring stiffness and valve quality on the motion behaviors of reciprocating plunger pump discharge valves was investigated by fluid structure interaction (FSI) simulation and experimental analysis. The mathematical model of the discharge valve motion of a 2000-fracturing pump was developed and the discrete differential equations were solved according to FSI and results obtained by ANDINA software. Results indicate that spring stiffness influences the maximum lift, the opening resistance and shut-off lag angle, as well as the fluid velocity of the clearance, the impact stress and the volume efficiency of the pump valve in relation to the valve quality...
2015: PloS One
https://www.readbyqxmd.com/read/26322031/metabolic-diversity-and-ecological-niches-of-achromatium-populations-revealed-with-single-cell-genomic-sequencing
#20
Muammar Mansor, Trinity L Hamilton, Matthew S Fantle, Jennifer L Macalady
Large, sulfur-cycling, calcite-precipitating bacteria in the genus Achromatium represent a significant proportion of bacterial communities near sediment-water interfaces at sites throughout the world. Our understanding of their potentially crucial roles in calcium, carbon, sulfur, nitrogen, and iron cycling is limited because they have not been cultured or sequenced using environmental genomics approaches to date. We utilized single-cell genomic sequencing to obtain one incomplete and two nearly complete draft genomes for Achromatium collected at Warm Mineral Springs (WMS), FL...
2015: Frontiers in Microbiology
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