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https://www.readbyqxmd.com/read/29678606/ketogenic-diet-high-intensity-interval-training-hiit-and-memory-training-in-the-treatment-of-mild-cognitive-impairment-a-case-study
#1
Kaitlyn Dahlgren, Kelly J Gibas
Alzheimer's disease (AD) deaths have increased by 89% since 2000. This alarming trajectory of neurological disease highlights the failure of current best practice. Deteriorating brain fuel supply is the nemesis of intact neurological health. Cerebral hypo-metabolism associated with AD occurs years before onset. Both the ketogenic diet and calorie restriction (fasting) lead to a compensatory rise in ketones to improve energy deficits in the brain derived from cerebral insulin resistance. Two forms of ketone bodies, β-hydroxybutyrate and acetoacetate, fuel the brain during starvation, fasting and strenuous exercise...
April 11, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29672614/adaptation-of-motor-unit-contractile-properties-in-rat-medial-gastrocnemius-to-treadmill-endurance-training-relationship-to-muscle-mitochondrial-biogenesis
#2
Katarzyna Kryściak, Joanna Majerczak, Jakub Kryściak, Dawid Łochyński, Dominik Kaczmarek, Hanna Drzymała-Celichowska, Piotr Krutki, Anna Gawedzka, Magdalena Guzik, Michał Korostynski, Zbigniew Szkutnik, Elżbieta Pyza, Wiesława Jarmuszkiewicz, Jerzy A Zoladz, Jan Celichowski
This study aimed at investigating the effects of 2, 4 and 8 weeks of endurance training on the contractile properties of slow (S), fast fatigue resistant (FR) and fast fatigable (FF) motor units (MUs) in rat medial gastrocnemius (MG) in relation to the changes in muscle mitochondrial biogenesis. The properties of functionally isolated MUs were examined in vivo. Mitochondrial biogenesis was judged based on the changes in mitochondrial DNA copy number (mtDNA), the content of the electron transport chain (ETC) proteins and PGC-1α in the MG...
2018: PloS One
https://www.readbyqxmd.com/read/29617448/ranking-of-osteogenic-potential-of-physical-exercises-in-postmenopausal-women-based-on-femoral-neck-strains
#3
Pim Pellikaan, Georgios Giarmatzis, Jos Vander Sloten, Sabine Verschueren, Ilse Jonkers
The current study aimed to assess the potential of different exercises triggering an osteogenic response at the femoral neck in a group of postmenopausal women. The osteogenic potential was determined by ranking the peak hip contact forces (HCFs) and consequent peak tensile and compressive strains at the superior and inferior part of the femoral neck during activities such as (fast) walking, running and resistance training exercises. Results indicate that fast walking (5-6 km/h) running and hopping induced significantly higher strains at the femoral neck than walking at 4 km/h which is considered a baseline exercise for bone preservation...
2018: PloS One
https://www.readbyqxmd.com/read/29615792/exercise-in-patients-with-hypertension-and-chronic-kidney-disease-a-randomized-controlled-trial
#4
Franklin C Barcellos, Fabricio Boscolo Del Vecchio, Annelise Reges, Gregore Mielke, Iná S Santos, Daniel Umpierre, Maristela Bohlke, Pedro C Hallal
Hypertension and chronic kidney disease (CKD) are global public health problems, both associated with higher risk of cardiovascular (CV) and renal events. This trial randomized non-diabetic adult patients with hypertension and CKD stages 2-4 to 16 weeks of aerobic and resistance training or usual care. The primary outcome was the change in estimated glomerular filtration rate (eGFR). Secondary outcomes included changes in systolic and diastolic blood pressure (BP), body weight, fasting blood glucose, lipid profile, high-sensitivity C-reactive protein (hs-CRP), and functional capacity...
April 4, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29596311/the-effects-of-isoflavone-supplementation-plus-combined-exercise-on-lipid-levels-and-inflammatory-and-oxidative-stress-markers-in-postmenopausal-women
#5
Jéssica S Giolo, Juliene G Costa, Jair P da Cunha-Junior, Ana Cláudia A M Pajuaba, Ernesto A Taketomi, Adriele V de Souza, Douglas C Caixeta, Leonardo G Peixoto, Erick P de Oliveira, Sarah Everman, Foued S Espindola, Guilherme M Puga
This study tested the effect of isoflavone supplementation in addition to combined exercise training on plasma lipid levels, inflammatory markers and oxidative stress in postmenopausal women. Thirty-two healthy and non-obese postmenopausal women without hormone therapy were randomly assigned to exercise + placebo (PLA; n = 15) or exercise + isoflavone supplementation (ISO; n = 17) groups. They performed 30 sessions of combined exercises (aerobic plus resistance) over ten weeks and consumed 100 mg of isoflavone supplementation or placebo...
March 29, 2018: Nutrients
https://www.readbyqxmd.com/read/29595056/live-cell-imaging-in-microfluidic-device-proves-resistance-to-oxygen-glucose-deprivation-in-hips-cms
#6
Sebastian Martewicz, Giulia Gabrel, Marika Campesan, Marcella Canton, Fabio Di Lisa, Nicola Elvassore
Analyses of cellular responses to fast oxygen dynamics are challenging and require ad hoc technological solutions, especial-ly when decoupling from liquid media composition is required. In this work, we present a microfluidic device specifically designed for culture analyses with high resolution and magnification objectives, providing full optical access to the cell cul-ture chamber. This feature allows fluorescence-based assays, photo-activated surface chemistry and live cell imaging under tightly controlled pO2 environments...
March 29, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29528961/the-short-term-training-and-detraining-effects-of-supervised-versus-unsupervised-resistance-exercise-in-aging-adults
#7
Samuel T Orange, Phil Marshall, Leigh A Madden, Rebecca V Vince
This study compared the effects of a 4-week supervised (SUP) and unsupervised (UNSUP) resistance training programme followed by 12 weeks of detraining (DET). Thirty-six healthy aging adults (age: 53.6 ± 3.6 years; body mass index: 28.3 ± 5.1 kg/m) were randomly allocated to a SUP group (n = 17) or an UNSUP group (n = 19). Participants completed three training sessions per week using resistance bands and body weight movements. Measures of physical performance were administered at baseline, at the end of the training programme, and after the DET period...
March 6, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29505553/prediction-of-liver-steatosis-applying-a-new-score-in-subjects-from-the-brazilian-longitudinal-study-of-adult-health
#8
Hugo Perazzo, Isabela Benseñor, José Geraldo Mill, Antônio G Pacheco, Maria de Jesus Mendes da Fonseca, Rosane Härter Griep, Paulo Lotufo, Dora Chor
GOALS: To develop a noninvasive algorithm for diagnosis of liver steatosis and to compare its diagnostic value with available predictive models. BACKGROUND: Liver steatosis represents the most frequent liver disease worldwide. STUDY: This cross-sectional study analyzed data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Patients were randomly divided into training (n=6571) and validation (n=3286) cohort. Abdominal ultrasound (US), used to grade steatosis, and overnight fasting blood tests were performed at the same day...
March 2, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29498935/structural-stability-of-coplanar-1t-2h-superlattice-mos2-under-high-energy-electron-beam
#9
Reshmi Sreedharan, Akshaya Mouly Vijayakumari, Biswarup Satpati, Palash Kumar Basu, Kuntala Bhattacharjee
Coplanar heterojunctions composed of van der Waals (vdW) layered materials with different structural polymorphs have drawn immense interest recently due to low contact resistance and high carrier injection rate owing to low Schottky barrier height. Present research has largely focused on efficient exfoliation of these layered materials and their restacking to achieve better performances. We present here a microwave (MW) assisted easy, fast and efficient route to induce high concentration of metallic 1T phase in the original 2H matrix of exfoliated MoS2 layers and thus facilitating the formation of a 1T-2H coplanar superlattice phase...
March 2, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29497353/how-much-protein-can-the-body-use-in-a-single-meal-for-muscle-building-implications-for-daily-protein-distribution
#10
REVIEW
Brad Jon Schoenfeld, Alan Albert Aragon
Controversy exists about the maximum amount of protein that can be utilized for lean tissue-building purposes in a single meal for those involved in regimented resistance training. It has been proposed that muscle protein synthesis is maximized in young adults with an intake of ~ 20-25 g of a high-quality protein; anything above this amount is believed to be oxidized for energy or transaminated to form urea and other organic acids. However, these findings are specific to the provision of fast-digesting proteins without the addition of other macronutrients...
2018: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/29492637/fibre-supplementation-for-the-prevention-of-type-2-diabetes-and-improvement-of-glucose-metabolism-the-randomised-controlled-optimal-fibre-trial-optifit
#11
Caroline Honsek, Stefan Kabisch, Margrit Kemper, Christiana Gerbracht, Ayman M Arafat, Andreas L Birkenfeld, Ulrike Dambeck, Martin A Osterhoff, Martin O Weickert, Andreas F H Pfeiffer
AIMS/HYPOTHESIS: Insoluble cereal fibres have been shown in large prospective cohort studies to be highly effective in preventing type 2 diabetes, but there is a lack of interventional data. Our 2 year randomised double-blind prospective intervention study compared the effect of an insoluble oat fibre extract with that of placebo on glucose metabolism and incidence of diabetes. METHODS: A total of 180 participants with impaired glucose tolerance underwent a modified version of the 1 year lifestyle training programme PREvention of DIAbetes Self-management (PREDIAS) and were randomised to receive a fibre supplement (n = 89; 7...
February 28, 2018: Diabetologia
https://www.readbyqxmd.com/read/29471132/high-intensity-body-weight-training-is-comparable-to-combined-training-in-changes-in-muscle-mass-physical-performance-inflammatory-markers-and-metabolic-health-in-postmenopausal-women-at-high-risk-for-type-2-diabetes-mellitus-a-randomized-controlled-clinical
#12
Fernanda Maria Martins, Aletéia de Paula Souza, Paulo Ricardo Prado Nunes, Márcia Antoniazi Michelin, Eddie Fernando Candido Murta, Elisabete Aparecida Mantovani Rodrigues Resende, Erick Prado de Oliveira, Fábio Lera Orsatti
OBJECTIVE: This study compared the effects of 12 weeks of high-intensity interval body weight training (HIBWT) with combined training (COMT; aerobic and resistance exercises on body composition, a 6-minute walk test (6MWT; physical performance), insulin resistance (IR) and inflammatory markers in postmenopausal women (PW) at high risk of type 2 diabetes mellitus (TDM2). METHODS: In this randomized controlled clinical study, 16 PW at high risk of TDM2 were randomly allocated into two groups: HIBWT (n = 8) and COMT (n = 8)...
February 19, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29431597/effect-of-movement-velocity-during-resistance-training-on-muscle-specific-hypertrophy-a-systematic-review
#13
Daniel A Hackett, Timothy B Davies, Rhonda Orr, Kenny Kuang, Mark Halaki
Currently, it is unclear whether manipulation of movement velocity during resistance exercise has an effect on hypertrophy of specific muscles. The purpose of this systematic review of literature was to investigate the effect of movement velocity during resistance training on muscle hypertrophy. Five electronic databases were searched using terms related to movement velocity and resistance training. Inclusion criteria were randomised and non-randomised comparative studies; published in English; included healthy adults; used dynamic resistance exercise interventions directly comparing fast training to slower movement velocity training; matched in prescribed intensity and volume; duration ≥4 weeks; and measured muscle hypertrophy...
February 12, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29413364/arachidonic-acid-supplementation-modulates-blood-and-skeletal-muscle-lipid-profile-with-no-effect-on-basal-inflammation-in-resistance-exercise-trained-men
#14
James F Markworth, Cameron J Mitchell, Randall F D'Souza, Kirsten M M Aasen, Brenan R Durainayagam, Sarah M Mitchell, Alex H C Chan, Andrew J Sinclair, Manohar Garg, David Cameron-Smith
Arachidonic acid (ARA), an omega-6 polyunsaturated fatty acid (PUFA), is the metabolic precursor to the eicosanoid family of lipid mediators. Eicosanoids have potent pro-inflammatory actions, but also act as important autocrine/paracrine signaling molecules in skeletal muscle growth and development. Whether dietary ARA is incorporated into skeletal muscle phospholipids and the resulting impact on intramuscular inflammatory and adaptive processes in-vivo is not known. In the current study, resistance trained men (≥1 year) received dietary supplementation with 1...
January 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29406784/resistance-training-recovers-attenuated-appl1-expression-and-improves-insulin-induced-akt-signal-activation-in-skeletal-muscle-of-type-2-diabetic-rats
#15
Kohei Kido, Satoru Ato, Takumi Yokokawa, Koji Sato, Satoshi Fujita
Adapter protein containing PH domain, PTB domain, and leucine zipper motif 1 (APPL1) has been reported as a positive regulator of insulin-stimulated Akt activation. The expression of APPL1 is reduced in skeletal muscles of type 2 diabetic (T2D) animals, implying that APPL1 may be an important factor affecting insulin sensitivity. However, the regulation of APPL1 expression and the physiological interventions modulating these effects are unclear. Accordingly, we first confirmed that APPL1 expression and Akt phosphorylation were significantly attenuated in skeletal muscles of T2D rats...
February 6, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29394488/effect-of-7-days-of-exercise-on-exogenous-carbohydrate-oxidation-and-insulin-resistance-in-children-with-obesity
#16
Lisa Chu, Katherine M Morrison, Michael C Riddell, Sandeep Raha, Brian W Timmons
PURPOSE: The capacity to match carbohydrate (CHO) oxidation with CHO availability (deemed metabolic flexibility (MetFlex)) may be important for type 2 diabetes prevention. In adults, impaired MetFlex is associated with insulin resistance (IR), which can be improved with as little as 7 days of exercise. Whether this occurs similarly in children is unknown. We hypothesized 7 consecutive days of exercise would improve MetFlex and IR in children with obesity. METHODS: Twelve children (8 boys, 4 girls) completed 2 study visits before (PRE) and 2 study visits after (POST) exercise training...
February 2, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29389245/the-effect-of-dietary-arachidonic-acid-supplementation-on-acute-muscle-adaptive-responses-to-resistance-exercise-in-trained-men-a-randomized-controlled-trial
#17
Cameron J Mitchell, Randall F D'Souza, Vandre Casagrande Figueiredo, Alex Chan, Kirsten M Aasen, Brenan Durainayagam, Sarah M Mitchell, Andrew J Sinclair, Ingrid Marie Egner, Truls Raastad, David Cameron-Smith, James F Markworth
Arachidonic acid (ARA), a polyunsaturated ω-6 fatty acid, acts as precursor to a number of prostaglandins with potential roles in muscle anabolism. It was hypothesized that ARA supplementation might enhance the early anabolic response to resistance exercise (RE) by increasing muscle protein synthesis (MPS) via mammalian target of rapamycin (mTOR) pathway activation, and/or the late anabolic response by modulating ribosome biogenesis and satellite cell expansion. Nineteen men with {greater than or equal to}1 year of resistance training experience were randomized to consume either 1...
February 1, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29387636/the-time-has-come-to-incorporate-a-greater-focus-on-rate-of-force-development-training-in-the-sports-injury-rehabilitation-process
#18
REVIEW
Matthew Buckthorpe, Giulio Sergio Roi
This narrative and literature review discusses the relevance of Rate of Force Development (RFD) (the slope of the force time curve) for Return To Sport (RTS), its determinants and the influence of training practices on it expression, with the purpose to enhance clinicians' awareness of how RFD training may enhance RTS success. RFD is considered functionally more relevant than maximal muscle strength during certain very fast actions including rapid joint stabilisation following mechanical perturbation. Deficits in RFD are reported following conventional rehabilitation programmes despite full restoration of maximal strength, which may contribute to the less than satisfactory RTS outcomes reported in the literature...
July 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/29334345/arm-crank-ergometry-improves-cardiovascular-disease-risk-factors-and-community-mobility-independent-of-body-composition-in-high-motor-complete-spinal-cord-injury
#19
James J Bresnahan, Gary J Farkas, Jody L Clasey, James W Yates, David R Gater
OBJECTIVE: Evaluate the effect of aerobic exercise using arm crank ergometry (ACE) in high motor complete (ISNCSCI A/B) spinal cord injury (SCI) as primarily related to cardiovascular disease (CVD) risk factors and functional mobility and secondarily to body composition and metabolic profiles. DESIGN: Longitudinal interventional study at an academic medical center. METHODS: Ten previously untrained participants (M8/F2, Age 36.7 y ± 10.1, BMI 24...
January 15, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29299199/swimming-training-alleviated-insulin-resistance-through-wnt3a-%C3%AE-catenin-signaling-in-type-2-diabetic-rats
#20
Qiang Yang, Wen-Wen Wang, Pu Ma, Zhong-Xuan Ma, Meng Hao, Temitope I Adelusi, Lei-Du, Xiao-Xing Yin, Qian Lu
Objectives: Increasing evidence suggests that regular physical exercise improves type 2 diabetes mellitus (T2DM). However, the potential beneficial effects of swimming on insulin resistance and lipid disorder in T2DM, and its underlying mechanisms remain unclear. Materials and Methods: Rats were fed with high fat diet and given a low dosage of Streptozotocin (STZ) to induce T2DM model, and subsequently treated with or without swimming exercise. An 8-week swimming program (30, 60 or 120 min per day, 5 days per week) decreased body weight, fasting blood glucose and fasting insulin...
November 2017: Iranian Journal of Basic Medical Sciences
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