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https://www.readbyqxmd.com/read/28215045/a-generalized-partially-linear-mean-covariance-regression-model-for-longitudinal-proportional-data-with-applications-to-the-analysis-of-quality-of-life-data-from-cancer-clinical-trials
#1
Xueying Zheng, Guoyou Qin, Dongsheng Tu
Motivated by the analysis of quality of life data from a clinical trial on early breast cancer, we propose in this paper a generalized partially linear mean-covariance regression model for longitudinal proportional data, which are bounded in a closed interval. Cholesky decomposition of the covariance matrix for within-subject responses and generalized estimation equations are used to estimate unknown parameters and the nonlinear function in the model. Simulation studies are performed to evaluate the performance of the proposed estimation procedures...
February 19, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28213793/automation-of-peak-tracking-analysis-of-stepwise-perturbed-nmr-spectra
#2
Tommaso Banelli, Marco Vuano, Federico Fogolari, Andrea Fusiello, Gennaro Esposito, Alessandra Corazza
We describe a new algorithmic approach able to automatically pick and track the NMR resonances of a large number of 2D NMR spectra acquired during a stepwise variation of a physical parameter. The method has been named Trace in Track (TINT), referring to the idea that a gaussian decomposition traces peaks within the tracks recognised through 3D mathematical morphology. It is capable of determining the evolution of the chemical shifts, intensity and linewidths of each tracked peak.The performances obtained in term of track reconstruction and correct assignment on realistic synthetic spectra were high above 90% when a noise level similar to that of experimental data were considered...
February 17, 2017: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/28212297/inorganic-reactive-sulfur-nitrogen-species-intricate-release-mechanisms-or-cacophony-in-yellow-blue-and-red
#3
Marian Grman, Muhammad Jawad Nasim, Roman Leontiev, Anton Misak, Veronika Jakusova, Karol Ondrias, Claus Jacob
Since the heydays of Reactive Sulfur Species (RSS) research during the first decade of the Millennium, numerous sulfur species involved in cellular regulation and signalling have been discovered. Yet despite the general predominance of organic species in organisms, recent years have also seen the emergence of inorganic reactive sulfur species, ranging from inorganic polysulfides (HSx(-)/Sx(2-)) to thionitrous acid (HSNO) and nitrosopersulfide (SSNO(-)). These inorganic species engage in a complex interplay of reactions in vitro and possibly also in vivo...
February 15, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28212047/multimaterial-decomposition-algorithm-for-the-quantification-of-liver-fat-content-by-using-fast-kilovolt-peak-switching-dual-energy-ct-clinical-evaluation
#4
Tomoko Hyodo, Norihisa Yada, Masatoshi Hori, Osamu Maenishi, Peter Lamb, Kosuke Sasaki, Minori Onoda, Masatoshi Kudo, Teruhito Mochizuki, Takamichi Murakami
Purpose To assess the clinical accuracy and reproducibility of liver fat quantification with the multimaterial decomposition (MMD) algorithm, comparing the performance of MMD with that of magnetic resonance (MR) spectroscopy by using liver biopsy as the reference standard. Materials and Methods This prospective study was approved by the institutional ethics committee, and patients provided written informed consent. Thirty-three patients suspected of having hepatic steatosis underwent non-contrast material-enhanced and triple-phase dynamic contrast-enhanced dual-energy computed tomography (CT) (80 and 140 kVp) and single-voxel proton MR spectroscopy within 30 days before liver biopsy...
February 17, 2017: Radiology
https://www.readbyqxmd.com/read/28212019/complete-nutrient-removal-coupled-to-nitrous-oxide-production-as-a-bioenergy-source-by-denitrifying-polyphosphate-accumulating-organisms
#5
Han Gao, Miaomiao Liu, James S Griffin, Longcheng Xu, Da Xiang, Yaniv D Scherson, Wen-Tso Liu, George F Wells
Coupled Aerobic-anoxic Nitrous Decomposition Operation (CANDO) is a promising emerging bioprocess for wastewater treatment that enables direct energy recovery from nitrogen (N) in three steps: (1) ammonium oxidation to nitrite; (2) denitrification of nitrite to nitrous oxide (N2O); and (3) N2O conversion to N2 with energy generation. However, CANDO does not currently target phosphorus (P) removal. Here, we demonstrate that denitrifying polyphosphate accumulating organism (PAO) enrichment cultures are capable of catalyzing simultaneous biological N and P removal coupled to N2O generation in a 2nd generation CANDO process, CANDO+P...
February 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28211923/electrical-and-photocatalytic-properties-of-boron-doped-zno-nanostructure-grown-on-pet-ito-flexible-substrates-by-hydrothermal-method
#6
Wei Wang, Taotao Ai, Qi Yu
Boron-doped zinc oxide sheet-spheres were synthesized on PET-ITO flexible substrates using a hydrothermal method at 90 °C for 5 h. The results of X-ray diffraction and X-ray photoelectron spectroscopy indicated that the B atoms were successfully doped into the ZnO lattice, the incorporation of B led to an increase in the lattice constant of ZnO and a change in its internal stress. The growth mechanism of pure ZnO nanorods and B-doped ZnO sheet-spheres was specifically investigated. The as-prepared BZO/PET-ITO heterojunction possessed obvious rectification properties and its positive turn-on voltage was 0...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211848/host-specificity-of-symbiodinium-variants-revealed-by-an-its2-metahaplotype-approach
#7
Edward G Smith, Remi N Ketchum, John A Burt
Analysis of the widely used ITS region is confounded by the presence of intragenomic variants (IGVs). In Symbiodinium, the algal symbionts of reef building corals, deep-sequencing analyses are used to characterise communities within corals, yet these analyses largely overlook IGVs. Here we consider that distinct ITS2 sequences could represent IGVs rather than distinct symbiont types and argue that symbionts can be distinguished by their proportional composition of IGVs, described as their ITS2 metahaplotype...
February 17, 2017: ISME Journal
https://www.readbyqxmd.com/read/28211137/energy-transfer-dynamics-of-formate-decomposition-on-cu-110
#8
Jiamei Quan, Takahiro Kondo, Guichang Wang, Junji Nakamura
Energy transfer dynamics of formate (HCOOa ) decomposition on a Cu(110) surface has been studied by measuring the angle-resolved intensity and translational energy distributions of CO2 emitted from the surface in a steady-state reaction of HCOOH and O2 . The angular distribution of CO2 shows a sharp collimation with the direction perpendicular to the surface, as represented by cos(n) θ (n=6). The mean translational energy of CO2 is measured to be as low as 100 meV and is independent of the surface temperature (Ts )...
February 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28210733/super-high-energy-density-single-bonded-trigonal-nitrogen-allotrope-a-chemical-twin-of-the-cubic-gauche-form-of-nitrogen
#9
Sergey V Bondarchuk, Boris F Minaev
A new ambient-pressure metastable single-bonded 3D nitrogen allotrope (TrigN) of trigonal symmetry (space group R3[combining macron]) was calculated using density functional theory (DFT). A comprehensive characterization of this material, comprising thermodynamic, elastic, and spectral (vibrational, UV-vis absorption, and nuclear magnetic resonance) properties, was performed. Using high-throughput band structure calculation, the TrigN phase was characterized as an insulator with an indirect band gap of 2.977 eV...
February 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28209583/combining-diffusion-tensor-metrics-and-dsc-perfusion-imaging-can-it-improve-the-diagnostic-accuracy-in-differentiating-tumefactive-demyelination-from-high-grade-glioma
#10
S B Hiremath, A Muraleedharan, S Kumar, C Nagesh, C Kesavadas, M Abraham, T R Kapilamoorthy, B Thomas
BACKGROUND AND PURPOSE: Tumefactive demyelinating lesions with atypical features can mimic high-grade gliomas on conventional imaging sequences. The aim of this study was to assess the role of conventional imaging, DTI metrics (p:q tensor decomposition), and DSC perfusion in differentiating tumefactive demyelinating lesions and high-grade gliomas. MATERIALS AND METHODS: Fourteen patients with tumefactive demyelinating lesions and 21 patients with high-grade gliomas underwent brain MR imaging with conventional, DTI, and DSC perfusion imaging...
February 16, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28208502/separation-of-cyclic-and-starlike-hierarchical-dominance-in-evolutionary-matrix-games
#11
György Szabó, Kinga S Bodó, Keivan Aghababaei Samani
We study antisymmetric components of matrices characterizing pair interactions in multistrategy evolutionary games. Based on the dyadic decomposition of matrices we distinguish cyclic and starlike hierarchical dominance in the appropriate components. In the symmetric matrix games the strengths of these elementary components are determined. The general features and intrinsic symmetries of these interactions are represented by directed graphs. It is found that the variation of a single matrix component modifies simultaneously the strengths of two starlike hierarchical basis games and many other independent rock-paper-scissors type cyclic basis games...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28208494/percolation-of-binary-disk-systems-modeling-and-theory
#12
Kelsey Meeks, John Tencer, Michelle L Pantoya
The dispersion and connectivity of particles with a high degree of polydispersity is relevant to problems involving composite material properties and reaction decomposition prediction and has been the subject of much study in the literature. This work utilizes Monte Carlo models to predict percolation thresholds for a two-dimensional systems containing disks of two different radii. Monte Carlo simulations and spanning probability are used to extend prior models into regions of higher polydispersity than those previously considered...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28208430/precursor-for-wind-reversal-in-a-square-rayleigh-b%C3%A3-nard-cell
#13
Bérengère Podvin, Anne Sergent
We investigate large-scale circulation reversals in a two-dimensional Rayleigh-Bénard cell using a proper orthogonal decomposition (POD)-based, five-mode model. The Rayleigh number considered is Ra=5×10^{7} and the Prandtl number is Pr=4.3. A precursor event, corresponding to the action of a mode L_{*} which disconnects the core region from the boundary layers before the onset of the reversal, is identified in the simulation. The five-mode model predicts correctly the behavior of the POD modes observed in the simulation, and in particular that of mode L_{*}...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28208287/highly-uniform-gold-nanobipyramids-for-ultrasensitive-colorimetric-detection-of-influenza-virus
#14
Shaohua Xu, Wenjun Ouyang, Peisi Xie, Yi Lin, Bin Qiu, Zhenyu Lin, Guonan Chen, Longhua Guo
Gold nanoparticles (AuNPs) have been frequently utilized for the construction of diverse colorimetric biosensors. Normally, AuNPs with sharp edges could have better sensitivity. However, the poor monodipersity of AuNPs with sharp edges seriously confines their utility for colorimetric biosensing. Herein, we demonstrate the utility of highly uniform gold nanobipyramids (Au NBPs) for ultrasensitive colorimetric detection of H5N1 virus. The proposed method is based on the fact that alkaline phosphatase (ALP) could catalyze the decomposition of 4-aminophenyl phosphate (4-APP) to generate 4-aminophenol (4-AP), which would then reduce silver nitrate to metal silver and then deposited on Au NBPs...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28208235/warmer-night-time-temperature-promotes-microbial-heterotrophic-activity-and-modifies-stream-sediment-community
#15
Anna Freixa, Vicenç Acuña, Maria Casellas, Stoyana Pecheva, Anna M Romaní
Diel temperature patterns are changing because of global warming, with higher temperatures being predicted to be more pronounced at night. Biological reactions are temperature dependent, with some occurring only during the daylight hours (e.g., light photosynthesis) and other during the entire day (e.g., respiration). Consequently, we expect the modification of daily temperature cycles to alter microbial biological reactions in stream sediments. Here, we aimed to study the effect of warming and changes of the diel temperature patterns on stream sediment biofilm functions tied to organic carbon decomposition, as well as on biofilm meiofaunal community structure...
February 16, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28208232/non-linear-co2-flux-response-to-seven-years-of-experimentally-induced-permafrost-thaw
#16
Marguerite Mauritz, Rosvel Bracho, Gerardo Celis, Jack Hutchings, Susan M Natali, Elaine Pegoraro, Verity G Salmon, Christina Schädel, Elizabeth E Webb, Edward A G Schuur
Rapid Arctic warming is expected to increase global greenhouse gas concentrations as permafrost thaw exposes immense stores of frozen carbon (C) to microbial decomposition. Permafrost thaw also stimulates plant growth, which could offset C loss. Using data from seven years of experimental Air and Soil warming in moist acidic tundra, we show that Soil warming had a much stronger effect on CO2 flux than Air warming. Soil warming caused rapid permafrost thaw and increased ecosystem respiration (Reco), gross primary productivity (GPP), and net summer CO2 storage (NEE)...
February 16, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28207404/a-noise-reduction-technique-based-on-nonlinear-kernel-function-for-heart-sound-analysis
#17
Ashok Mondal, Ishan Saxena, Hong Tang, Poulami Banerjee
The main difficulty encountered in interpretation of cardiac sound is interference of noise. The contaminated noise obscures the relevant information which are useful for recognition of heart diseases. The unwanted signals are produced mainly by lungs and surrounding environment. In this paper, a novel heart sound de-noising technique has been introduced based on a combined framework of wavelet packet transform (WPT) and singular value decomposition (SVD). The most informative node of wavelet tree is selected on the criteria of mutual information measurement...
February 13, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28207403/predictive-walking-age-health-analyzer
#18
Priyanka Mandal, Krishna Tank, Tapas Monday, Chih-Hung Chen, M Jamal Deen
A simple, low-power and wearable health analyzer for early identification and management of some diseases is presented. To achieve this goal, we propose a walking pattern analysis system that uses features such as speed, energy, turn ratio, and bipedal behavior to characterize and classify individuals in distinct walking-ages. A database is constructed from 74 healthy young adults in the age range of 18 to 60 years using the combination of inertial signals from an accelerometer and a gyroscope on a level path including turns...
February 9, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28205646/connexin30-3-is-expressed-in-mouse-embryonic-stem-cells-and-is-responsive-to-leukemia-inhibitory-factor
#19
Mikako Saito, Yuma Asai, Keiichi Imai, Shoya Hiratoko, Kento Tanaka
The expression of 19 connexin (Cx) isoforms was observed in the mouse embryonic stem (ES) cell line, EB3. Their expression patterns could be classified into either pluripotent state-specific, differentiating stage-specific, or non-specific Cxs. We focused on Cx30.3 as typical of the first category. Cx30.3 was pluripotent state-specific and upregulated by leukemia inhibitory factor (LIF), a specific cytokine that maintains the pluripotent state of ES cell, via a Jak signaling pathway. Cx30.3 protein was localized to both the cell membrane and cytosol...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28205289/functionally-dissimilar-neighbors-accelerate-litter-decomposition-in-two-grass-species
#20
Lou Barbe, Vincent Jung, Andreas Prinzing, Anne-Kristel Bittebiere, Olaf Butenschoen, Cendrine Mony
Plant litter decomposition is a key regulator of nutrient recycling. In a given environment, decomposition of litter from a focal species depends on its litter quality and on the efficiency of local decomposers. Both may be strongly modified by functional traits of neighboring species, but the consequences for decomposition of litter from the focal species remain unknown. We tested whether decomposition of a focal plant's litter is influenced by the functional-trait dissimilarity to the neighboring plants. We cultivated two grass species (Brachypodium pinnatum and Elytrigia repens) in experimental mesocosms with functionally similar and dissimilar neighborhoods, and reciprocally transplanted litter...
February 16, 2017: New Phytologist
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