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https://www.readbyqxmd.com/read/29463209/characterisation-of-zika-virus-infection-in-primary-human-astrocytes
#1
Michal Stefanik, Petra Formanova, Tomas Bily, Marie Vancova, Ludek Eyer, Martin Palus, Jiri Salat, Carla Torres Braconi, Paolo M de A Zanotto, Ernest A Gould, Daniel Ruzek
BACKGROUND: The recent Zika virus (ZIKV) outbreak has linked ZIKV with microcephaly and other central nervous system pathologies in humans. Astrocytes are among the first cells to respond to ZIKV infection in the brain and are also targets for virus infection. In this study, we investigated the interaction between ZIKV and primary human brain cortical astrocytes (HBCA). RESULTS: HBCAs were highly sensitive to representatives of both Asian and African ZIKV lineages and produced high viral yields...
February 20, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29462879/chondrocytes-contribute-to-alphaviral-disease-pathogenesis-as-a-source-of-virus-replication-and-soluble-factor-production
#2
Elisa X Y Lim, Aroon Supramaniam, Hayman Lui, Peta Coles, Wai Suet Lee, Xiang Liu, Penny A Rudd, Lara J Herrero
Arthritogenic alphavirus infections often result in debilitating musculoskeletal disorders that affect the joints, muscle, and bone. In order to evaluate the infection profile of primary human skeletal muscle and chondrocyte cells to Ross River virus (RRV) in vitro, cells were infected at a multiplicity of infection (MOI) of 1 over a period of two days. Viral titers were determined by plaque assay and cytokine expression by Bio-Plex® assays using the supernatants harvested. Gene expression studies were conducted using total RNA isolated from cells...
February 15, 2018: Viruses
https://www.readbyqxmd.com/read/29451216/does-combined-therapy-of-curcumin-and-epigallocatechin-gallate-have-a-synergistic-neuroprotective-effect-against-spinal-cord-injury
#3
Jiri Ruzicka, Lucia Machova Urdzikova, Barbora Svobodova, Anubhav G Amin, Kristyna Karova, Jana Dubisova, Kristyna Zaviskova, Sarka Kubinova, Meic Schmidt, Meena Jhanwar-Uniyal, Pavla Jendelova
Systematic inflammatory response after spinal cord injury (SCI) is one of the factors leading to lesion development and a profound degree of functional loss. Anti-inflammatory compounds, such as curcumin and epigallocatechin gallate (EGCG) are known for their neuroprotective effects. In this study, we investigated the effect of combined therapy of curcumin and EGCG in a rat model of acute SCI induced by balloon compression. Immediately after SCI, rats received curcumin, EGCG, curcumin + EGCG or saline [daily intraperitoneal doses (curcumin, 6 mg/kg; EGCG 17 mg/kg)] and weekly intramuscular doses (curcumin, 60 mg/kg; EGCG 17 mg/kg)] for 28 days...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29445009/human-binge-alcohol-intake-inhibits-tlr4-myd88-and-tlr4-trif-responses-but-not-the-tlr3-trif-pathway-hspa1a-and-pp1-play-selective-regulatory-roles
#4
Sujatha Muralidharan, Arlene Lim, Donna Catalano, Pranoti Mandrekar
Binge/moderate alcohol suppresses TLR4-MyD88 proinflammatory cytokines; however, alcohol's effects on TLR-TRIF signaling, especially after in vivo exposure in humans, are unclear. We performed a comparative analysis of the TLR4-MyD88, TLR4-TRIF, and TLR3-TRIF pathways in human monocytes following binge alcohol exposure. Mechanistic regulation of TLR-TRIF signaling by binge alcohol was evaluated by analyzing IRF3 and TBK1, upstream regulator protein phosphatase 1 (PP1), and immunoregulatory stress proteins HspA1A and XBP-1 in alcohol-treated human and mouse monocytes/macrophages...
February 14, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29442720/ceria-oxide-nanoparticles-an-ideal-carrier-given-little-stress-to-cells-and-rats
#5
Tongwang Yang, Tao Wu, Liping Lv, Zhiqiang Zhang, Dongjie Liu, Jianji Xu, Dexi Chen, Gang Wu
Nanoparticles were used as ideal carrier for its passive and active targeting property. Unfortunately, many of them were failed for its biotoxicology. Thus, find a safe and targeted drug delivery was the new goal of pharmaceutical industries. Here, A549 and H1299 cells were exposed to ceria oxide nanoparticles, silicon oxide nanoparticles and zinc oxide nanoparticles for 12 h to induce autophagy and late apoptosis. Rats were exposed to ceria oxide nanoparticles (20 mg/kg · bw) for 1, 7, 14 or 28 days to induce lung injury and cytokines change...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29435110/transfusion-associated-adverse-reactions-taars-and-cytokine-accumulations-in-the-stored-blood-components-the-impact-of-prestorage-versus-poststorage-leukoreduction
#6
Chih-Chun Chang, Tai-Chen Lee, Ming-Jang Su, Hsiu-Chen Lin, Fang-Yi Cheng, Yi-Ting Chen, Tzung-Hai Yen, Fang-Yeh Chu
Leukoreduction in blood units could prevent patients undergoing transfusions from transfusion-associated adverse reactions (TAARs) such as febrile nonhemolytic transfusion reactions (FNHTRs). However, the effect of prestorage and poststorage leukoreduction on TAARs and its underlying mechanisms in stored blood components remains to be determined. Therefore, we investigated the impact of prestorage leukocyte-reduced (pre-LR) and poststorage leukocyte-reduced (post-LR) blood products, including red blood cells (RBCs) and apheresis platelets (PHs), on the incidence of FNHTRs and other TAARs in patients who received transfusions from 2009 to 2014 in a tertiary care center...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29433864/leukoreduction-of-packed-red-blood-cells-attenuates-proinflammatory-properties-of-storage-derived-microvesicles
#7
Jillian R Richter, Jeffrey M Sutton, Phillip Hexley, Taylor A Johannigman, Alex B Lentsch, Timothy A Pritts
BACKGROUND: Leukoreduction prior to packed red blood cell (pRBC) storage is not a universally accepted practice. Our laboratory has previously shown that microvesicles (MVs) accumulate in pRBC units during storage and play an important role in lung injury after resuscitation. Currently, the effect of leukoreduction on MV formation in stored pRBC units is unknown. In the present study, we investigated the hypothesis that leukoreduction of pRBC units prior to storage would attenuate the production of MVs and decrease pulmonary inflammation after hemorrhage and resuscitation...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29433015/effect-of-strenuous-exercise-on-mediators-of-inflammation-in-patients-with-coronary-artery-disease
#8
Joanna Cwikiel, Ingebjørg Seljeflot, Eivind Berge, Ida Unhammer Njerve, Hilde Ulsaker, Harald Arnesen, Arnljot Flaa
BACKGROUND: Coronary artery disease (CAD) is considered a low-grade inflammatory disease. We aimed to identify effects of short-term strenuous exercise on mediators of systemic inflammation, endothelial and platelet activation in patients with angiographically verified CAD. We hypothesized that a more pronounced inflammatory response would be present in patients with CAD than in those without CAD. METHODS: In subjects with symptoms indicative of stable CAD, an exercise stress test on a bicycle ergometer was performed...
February 9, 2018: Cytokine
https://www.readbyqxmd.com/read/29428678/profiling-cytokine-levels-in-chlorhexidine-and-egcg-treated-odontoblast-like-cells
#9
Alexander Terry Stavroullakis, Marcela Rocha Carrilho, Celine Marie Levesque, Anuradha Prakki
OBJECTIVE: To screen the effect of two compounds, chlorhexidine diacetate (CHX) and epigallocatechin-gallate (EGCG), on the levels of cytokines produced by odontoblast-like cells (MDPC-23). METHODS: Cells were seeded at 24h and 48h with serial dilution of the compounds to determine cell metabolic activity by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay (n=3). Cells with no compound treatment were used as control (Ctr). For the highest equal non-cytotoxic compound dilution tested at 48h cell treatment, total protein concentration was measured using a Pierce bicinchoninic acid (BCA) assay (n=3), and expression of 23 cytokines was analyzed using the Bio-Plex cytokine assay (n=2)...
February 7, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29427908/kinetics-of-viral-load-and-cytokines-in-severe-fever-with-thrombocytopenia-syndrome
#10
Ji-Soo Kwon, Min-Chul Kim, Ji Yeun Kim, Na-Young Jeon, Byung-Han Ryu, Jeongmin Hong, Min-Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease in China, Japan, and Korea, which is characterized by high fever, thrombocytopenia, and high mortality. It is hypothesized that a cytokine storm plays an important role in the pathophysiology of SFTS. However, limited data have been published on the detailed kinetics of the viral load and cytokine profiles throughout the course of this disease. OBJECTIVES: We investigated the patterns of changes in cytokines and viral load in SFTS patients...
January 31, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29422084/anti-cd11b-antibody-treatment-suppresses-the-osteoclast-generation-inflammatory-cell-infiltration-and-autoantibody-production-in-arthritis-prone-fc%C3%AE-riib-deficient-mice
#11
Mareki Ohtsuji, Qingshun Lin, Hideki Okazaki, Kazuko Takahashi, Hirofumi Amano, Hideo Yagita, Hiroyuki Nishimura, Sachiko Hirose
BACKGROUND: Previously we established an arthritis-prone FcγRIIB-deficient mouse strain (designated KO1). Anti-mouse CD11b mAb (5C6) has been reported to inhibit the recruitment of peripheral CD11b + myelomonocytic cells from the blood to the inflammatory site. These cells include neutrophils and monocytes, both of which play important roles in the development of arthritis. Here we treated KO1 mice with 5C6 mAb in order to study its effect on arthritis development. METHODS: To evaluate the disease-preventive effect of 5C6, 4-month-old preclinical KO1 mice were divided into three groups: the first treated with 5C6 for 6 months, the second treated with normal rat IgG for 6 months, as a control, and the third left untreated...
February 8, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29421523/maraviroc-improves-hepatic-triglyceride-content-but-not-inflammation-in-a-murine-nonalcoholic-fatty-liver-disease-model-induced-by-a-chronic-exposure-to-high-fat-diet
#12
Laura Pérez-Martínez, Laura Ochoa-Callejero, Susana Rubio-Mediavilla, Judit Narro, Iván Bernardo, José-Antonio Oteo, José-Ramón Blanco
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the general population. Its severity ranges from simple steatosis to cirrhosis. C-C chemokine ligand type 5 or RANTES plays an important role in the progression of hepatic inflammation and fibrosis. Our objective was to examine the preventive and therapeutic effects of maraviroc (MVC), a C-C chemokine receptor 5 antagonist, on liver pathology in an NAFLD mouse model. A total of 60 male C57BL/6 mice were randomly assigned to 1 of 4 groups: (1) high-fat diet (HFD) group or control group, (2) preventive group (HFD group plus MVC in drinking water since the beginning of the study), (3) early-therapeutic group (HFD group plus MVC in drinking starting at week 24 of the study), and (4) late-therapeutic group (HFD group plus MVC in drinking water starting at week 36 of the study)...
January 31, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29417576/olfactory-and-middle-meatal-cytokine-levels-correlate-with-olfactory-function-in-chronic-rhinosinusitis
#13
Jeffanie Wu, Rakesh K Chandra, Ping Li, Benjamin P Hull, Justin H Turner
OBJECTIVES/HYPOTHESIS: The etiology of chronic rhinosinusitis (CRS)-associated olfactory loss is unclear, but may result from inflammatory changes in the olfactory epithelium that result in signaling dysfunction or loss of olfactory neurons. Several proinflammatory cytokines have been associated with CRS, but their expression within the olfactory cleft microenvironment and association with olfactory function is unknown. STUDY DESIGN: Prospective case-control study...
February 8, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29411555/innate-immune-response-to-viral-infections-in-primary-bronchial-epithelial-cells-is-modified-by-the-atopic-status-of-asthmatic-patients
#14
Sylwia Moskwa, Wojciech Piotrowski, Jerzy Marczak, Małgorzata Pawełczyk, Anna Lewandowska-Polak, Marzanna Jarzębska, Małgorzata Brauncajs, Anna Głobińska, Paweł Górski, Nikolaos G Papadopoulos, Michael R Edwards, Sebastian L Johnston, Marek L Kowalski
PURPOSE: In order to gain an insight into determinants of reported variability in immune responses to respiratory viruses in human bronchial epithelial cells (HBECs) from asthmatics, the responses of HBEC to viral infections were evaluated in HBECs from phenotypically heterogeneous groups of asthmatics and in healthy controls. METHODS: HBECs were obtained during bronchoscopy from 10 patients with asthma (6 atopic and 4 non-atopic) and from healthy controls (n=9) and grown as undifferentiated cultures...
March 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29410193/inflammation-associated-cytokines-igfbp1-and-rantes-impair-the-megakaryocytic-potential-of-hscs-in-pt-patients-after-allo-hsct
#15
Cuicui Liu, Yiqing Yang, Dan Wu, Wenxia Zhang, Hongtao Wang, Pei Su, Jianfeng Yao, Chen Liang, Sizhou Feng, Mingzhe Han, Fuxu Wang, Erlie Jiang, Jiaxi Zhou
Prolonged isolated thrombocytopenia (PT) is a severe complication in patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Whether the megakaryoctic potential of hematopoietic stem cells (HSCs) in bone marrow is intact and what factors drive the pathological process of PT remain elusive. A retrospective study in patients (n=285) receiving HSC transplantation revealed that the occurrence of PT was approximately 8% and the number of platelets and megakaryocytes in PT patients is much lower compared to the control...
January 31, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29402845/key-proteins-involved-in-spheroid-formation-and-angiogenesis-in-endothelial-cells-after-long-term-exposure-to-simulated-microgravity
#16
Anita Dittrich, Daniela Grimm, Jayashree Sahana, Johann Bauer, Marcus Krüger, Manfred Infanger, Nils E Magnusson
BACKGROUND/AIMS: Cardiovascular complications are common in astronauts returning from a prolonged spaceflight. These health problems might be driven by complex modulations of gene expression and protein synthesis in endothelial cells (ECs). Studies on the influence of microgravity on phenotype, growth pattern and biological processes of ECs can help to understand these complications. METHODS: We exposed ECs (EA.hy926) to a Random Positioning Machine (RPM). Proteins associated with cell structure, angiogenesis and endothelial dysfunction were investigated in distinct pools of multicellular spheroids (MCS), adherent cells (AD) and tubular structures (TS) formed after a 35-day RPM-exposure...
January 24, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29399390/ccl3-augments-tumor-rejection-and-enhances-cd8-t-cell-infiltration-through-nk-and-cd103-dendritic-cell-recruitment-via-ifn%C3%AE
#17
Frederick Allen, Iuliana D Bobanga, Peter Rauhe, Deborah Barkauskas, Nathan Teich, Caryn Tong, Jay Myers, Alex Y Huang
Inflammatory chemokines are critical contributors in attracting relevant immune cells to the tumor microenvironment and driving cellular interactions and molecular signaling cascades that dictate the ultimate outcome of host anti-tumor immune response. Therefore, rational application of chemokines in a spatial-temporal dependent manner may constitute an attractive adjuvant in immunotherapeutic approaches against cancer. Existing data suggest that the macrophage inflammatory protein (MIP)-1 family and related proteins, consisting of CCL3 (MIP-1α), CCL4 (MIP-1β), and CCL5 (RANTES), can be major determinant of immune cellular infiltration in certain tumors through their direct recruitment of antigen presenting cells, including dendritic cells (DCs) to the tumor site...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29396486/in-vivo-microbiome-and-associated-immune-markers-new-insights-into-the-pathogenesis-of-vaginal-dysbiosis
#18
Giuseppina Campisciano, Nunzia Zanotta, Danilo Licastro, Francesco De Seta, Manola Comar
The microbiota fulfils a key role in the training and function of the immune system, which contributes to the symbiosis between the host and complex microbial communities. In this study, we characterized the interplay between vaginal bacteria and local immune mediators during dysbiosis in selected women of reproductive age who were grouped according to Nugent's criteria. The abundance of Gardnerella vaginalis and Bifidobacterium breve was increased in the intermediate dysbiotic status, while the presence of a plethora of non-resident bacteria characterized the group with overt vaginosis...
February 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29383037/interferon-gamma-an-important-marker-of-response-to-immune-checkpoint-blockade-in-non-small-cell-lung-cancer-and-melanoma-patients
#19
Niki Karachaliou, Maria Gonzalez-Cao, Guillermo Crespo, Ana Drozdowskyj, Erika Aldeguer, Ana Gimenez-Capitan, Cristina Teixido, Miguel Angel Molina-Vila, Santiago Viteri, Maria De Los Llanos Gil, Salvador Martin Algarra, Elisabeth Perez-Ruiz, Ivan Marquez-Rodas, Delvys Rodriguez-Abreu, Remedios Blanco, Teresa Puertolas, Maria Angeles Royo, Rafael Rosell
Background: Programmed death-ligand 1 (PD-L1) may be induced by oncogenic signals or can be upregulated via interferon gamma (IFN-γ). We have explored whether the expression of IFNG, the gene encoding IFN-γ, is associated with clinical response to the immune checkpoint blockade in non-small cell lung cancer (NSCLC) and melanoma patients. The role of inflammation-associated transcription factors STAT3, IKBKE, STAT1 and other associated genes has also been examined. Methods: Total RNA from 17 NSCLC and 21 melanoma patients was analyzed by quantitative reverse transcription PCR...
2018: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29382111/yirui-capsules-alleviate-atherosclerosis-by-improving-the-lipid-profile-and-reducing-inflammation-in-apolipoprotein-e-deficient-mice
#20
Jiqu Xu, Zumeng Xia, Shuang Rong, Hui Gao, Wei Yang, Jieliang Li, Congcong Ma, Qianchun Deng, Qingde Huang, Lingyun Xiao, Fenghong Huang
Atherosclerosis (AS) is the main cause of cardiovascular diseases. This study investigated Yirui (YR) capsules, whose ingredients are available in health food stores, against AS and the underlying mechanisms. Male apolipoprotein E-deficient mice fed a high-fat diet for 10 weeks developed severe aortic lesions, but YR significantly decreased the plaque area in the total aorta and aortic root. YR affected the serum lipid profile by significantly reducing total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and oxidative modification of LDL-C (Ox-LDL) levels...
January 29, 2018: Nutrients
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