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https://www.readbyqxmd.com/read/29665857/the-htlv-1-oncoprotein-tax-is-modified-by-the-ubiquitin-related-modifier-1-urm1
#1
Rita Hleihel, Behzad Khoshnood, Ingrid Dacklin, Hayssam Omran, Carine Mouawad, Zeina Dassouki, Marwan El-Sabban, Margret Shirinian, Caroline Grabbe, Ali Bazarbachi
BACKGROUND: Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy secondary to chronic human T-cell lymphotropic virus 1 infection, triggered by the virally encoded oncoprotein Tax. The transforming activity and subcellular localization of Tax is strongly influenced by posttranslational modifications, among which ubiquitylation and SUMOylation have been identified as key regulators of the nuclear/cytoplasmic shuttling of Tax, as well as its ability to activate NF-κB signaling...
April 17, 2018: Retrovirology
https://www.readbyqxmd.com/read/29660465/jageum-jung-improves-2-4-dinitrochlorobenzene-induced-atopic-dermatitis-like-skin-lesions-in-mice-and-suppresses-pro-inflammatory-chemokine-production-by-inhibiting-tnf-%C3%AE-ifn-%C3%AE-induced-stat-1-and-nf%C3%AE%C2%BAb-signaling-in-hacat-cells
#2
Ju-Hye Yang, Hyun Ju Do, Esther Lee, Nam-Hui Yim, Won-Kyung Cho, Kwang-Il Park, Jin Yeul Ma
ETHNOPHARMACOLOGICAL RELEVANCE: Jageum-Jung (JGJ) is an oriental herbal formula comprising five herbs (Melaphis chinensis Bell, Cremastra variabilis Nakai, Knoxia valerianoides Thorel, Euphorbia lathyris L., and Moschus moschiferus L.). It has been used for detoxification and treating cancer and inflammatory diseases in China, Japan, and Korea. However, the mechanism of action of JGJ on keratinocyte inflammatory response is poorly understood. AIM OF THE STUDY: In the present study, we investigated the anti-inflammatory mechanism of JGJ and studied the effects of JGJ on atopic dermatitis-like skin lesions in mice...
April 13, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29652553/mahonia-oiwakensis-extract-and-its-bioactive-compounds-exert-anti-inflammatory-activities-and-vegf-production-through-m2-macrophagic-polarization-and-stat6-activation
#3
Yea-Chen Liu, Yu-Ying Hsiao, Kuo-Lung Ku, Hui-Fen Liao, Wei-Chun Chao
Macrophages play an indispensable role in the host immune defense. Macrophages can undergo polarization into classically (M1) and alternatively (M2) activated macrophages. M1 macrophages activate immune and inflammatory response, while M2 macrophages are involved in tissue remodeling. Mahonia oiwakensis (Mo) is a herbal medicine in Asia used for its anti-inflammatory and analgesic properties; however, the mechanism is unclear. This study analyzed the effect of Mo extracts and its effects on the polarization of both macrophage RAW264...
April 13, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29643956/serum-cytokines-in-early-prediction-of-anastomotic-leakage-following-low-anterior-resection
#4
Marek Zawadzki, Małgorzata Krzystek-Korpacka, Andrzej Gamian, Wojciech Witkiewicz
Introduction: Anastomotic leakage continues to be one of the most serious complications following low anterior resections. Early diagnosis of a leak is difficult but critical to minimize morbidity and mortality. Aim: To evaluate changes in serum concentrations of 27 different cytokines following low anterior resection, with the goal of finding new, early biomarkers of anastomotic leak. Material and methods: This is a prospective observational study that includes 32 patients undergoing elective low anterior resection for rectal cancer...
March 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29629347/%C3%AE-carotene-inhibits-activation-of-nf-%C3%AE%C2%BAb-activator-protein-1-and-stat3-and-regulates-abnormal-expression-of-some-adipokines-in-3t3-l1-adipocytes
#5
Soon Ok Cho, Min-Hyun Kim, Hyeyoung Kim
Background: Oxidative stress occurs in white adipose tissue and dysregulates the expression of adipokines secreted from adipocytes. Since adipokines influence inflammation, supplementation with antioxidants might be beneficial for preventing oxidative stress-mediated inflammation in adipocytes and inflammation-associated complications. β-Carotene is the most prominent antioxidant carotenoid and scavenges reactive oxygen species in various tissues. The purpose of this study was to determine whether β-carotene regulates the expression of adipokines, such as adiponectin, monocyte chemoattractant protein-1 (MCP-1), and regulated on activation, normal T cell expressed and secreted (RANTES) in 3T3-L1 adipocytes treated with glucose/glucose oxidase (G/GO)...
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29616026/downregulation-of-slc7a7-triggers-an-inflammatory-phenotype-in-human-macrophages-and-airway-epithelial-cells
#6
Bianca Maria Rotoli, Amelia Barilli, Rossana Visigalli, Filippo Ingoglia, Marco Milioli, Maria Di Lascia, Benedetta Riccardi, Paola Puccini, Valeria Dall'Asta
Lysinuric protein intolerance (LPI) is a recessively inherited aminoaciduria caused by mutations of SLC7A7, the gene encoding y+LAT1 light chain of system y+ L for cationic amino acid transport. The pathogenesis of LPI is still unknown. In this study, we have utilized a gene silencing approach in macrophages and airway epithelial cells to investigate whether complications affecting lung and immune system are directly ascribable to the lack of SLC7A7 or, rather, mediated by an abnormal accumulation of arginine in mutated cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29605406/micro-rna-profile-and-proteins-in-peritoneal-fluid-from-women-with-endometriosis-their-relationship-with-sterility
#7
Josep Marí-Alexandre, Moisés Barceló-Molina, Elisa Belmonte-López, Javier García-Oms, Amparo Estellés, Aitana Braza-Boïls, Juan Gilabert-Estellés
OBJECTIVE: To define the microRNA (miRNA) profile and its relationship with cytokines content in peritoneal fluid (PF) from endometriosis patients. DESIGN: Case-control study. SETTING: University hospital, research institute. PATIENT(S): One hundred twenty-six women with endometriosis (EPF) and 45 control women (CPF). MAIN OUTCOMES MEASURE(S): MiRNA arrays were prepared from six EPF and six CPF...
March 28, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29605095/activated-renal-tubular-wnt-%C3%AE-catenin-signaling-triggers-renal-inflammation-during-overload-proteinuria
#8
Dickson W L Wong, Wai Han Yiu, Kam Wa Chan, Ye Li, Bin Li, Sarah W Y Lok, Makoto M Taketo, Peter Igarashi, Loretta Y Y Chan, Joseph C K Leung, Kar Neng Lai, Sydney C W Tang
Imbalance of Wnt/β-catenin signaling in renal cells is associated with renal dysfunction, yet the precise mechanism is poorly understood. Previously we observed activated Wnt/β-catenin signaling in renal tubules during proteinuric nephropathy with an unknown net effect. Therefore, to identify the definitive role of tubular Wnt/β-catenin, we generated a novel transgenic "Tubcat" mouse conditionally expressing stabilized β-catenin specifically in renal tubules following tamoxifen administration...
March 28, 2018: Kidney International
https://www.readbyqxmd.com/read/29603339/tricin-inhibits-ccl5-induction-required-for-the-efficient-growth-of-human-cytomegalovirus
#9
Akimasa Itho, Hidetaka Sadanari, Masaya Takemoto, Keiko Matsubara, Tohru Daikoku, Tsugiya Murayama
It has been reported that treatment of human embryonic lung fibroblast (HEL) cells with tricin (4', 5, 7-trihydroxy-3', 5'-dimethoxyflavone) following infection by human cytomegalovirus (HCMV) significantly suppresses HCMV replication. In the present work, we examined the mechanisms for the anti-HCMV effects of tricin in HEL cells. Exposure of HEL cells to tricin inhibited HCMV replication, with concomitant decreases in transcripts levels of the CC chemokine RANTES (CCL5) - encoding gene and in the expression of the CCL5 protein...
March 30, 2018: Microbiology and Immunology
https://www.readbyqxmd.com/read/29596680/differential-antiviral-activities-of-respiratory-syncytial-virus-rsv-inhibitors-in-human-airway-epithelium
#10
Carmen Mirabelli, Martine Jaspers, Mieke Boon, Mark Jorissen, Mohamed Koukni, Dorothée Bardiot, Patrick Chaltin, Arnaud Marchand, Johan Neyts, Dirk Jochmans
Objectives: We report the use of reconstituted 3D human airway epithelium cells (HuAECs) of bronchial origin in an air-liquid interface to study respiratory syncytial virus (RSV) infection and to assess the efficacy of RSV inhibitors in (pre-)clinical development. Methods: HuAECs were infected with RSV-A Long strain (0.01 CCID50/cell, where CCID50 represents 50% cell culture infectious dose in HEp2 cells) on the apical compartment of the culture. At the time of infection or at 1 or 3 days post-infection, selected inhibitors were added and refreshed daily on the basal compartment of the culture...
March 27, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29588233/postpartum-increases-in-cerebral-edema-and-inflammation-in-response-to-placental-ischemia-during-pregnancy
#11
Ahsia M Clayton, Qingmei Shao, Nina D Paauw, Ashtin B Giambrone, Joey P Granger, Junie P Warrington
Reduced placental blood flow results in placental ischemia, an initiating event in the pathophysiology of preeclampsia, a hypertensive pregnancy disorder. While studies show increased mortality risk from Alzheimer's disease, stroke, and cerebrovascular complications in women with a history of preeclampsia, the underlying mechanisms are unknown. During pregnancy, placental ischemia, induced by reducing uterine perfusion pressure (RUPP), leads to cerebral edema and increased blood-brain barrier (BBB) permeability; however whether these complications persist after delivery is not known...
March 24, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29582436/modifiers-of-mesenchymal-stem-cell-quantity-and-quality
#12
Athena L Russell, Rebecca Lefavor, Nisha Durand, Loren Glover, Abba C Zubair
BACKGROUND: Clinical trials involving mesenchymal stem cell (MSC) therapy have variable outcomes. We hypothesize this is largely attributed to donor-to-donor variability and tissue of origin. STUDY DESIGN AND METHODS: We examined proliferation rates, cytokine secretion profiles, and differentiation capability of seven bone marrow-derived MSCs (BM-MSCs) and 16 adipose tissue-derived MSCs (AD-MSCs) from 23 donors. RESULTS: AD-MSCs had the capacity to undergo more than 40 population doublings, while the BM-MSC proliferation rate was found to be considerably slower...
March 26, 2018: Transfusion
https://www.readbyqxmd.com/read/29579332/late-therapeutic-intervention-with-a-respiratory-syncytial-virus-l-protein-polymerase-inhibitor-pc786-on-rsv-infection-in-human-airway-epithelium
#13
Daniel W Brookes, Matthew Coates, Heather Allen, Leah Daly, Samuel Constant, Song Huang, Mark Hows, Amanda Davis, Lindsey Cass, John Ayrton, Ian Knowles, Pete Strong, Garth W Rapeport, Kazuhiro Ito
BACKGROUND AND PURPOSE: Effective anti-respiratory syncytial virus (RSV) agents are still not available for clinical use. Current major targets are virus surface proteins, such as a fusion-protein involved in viral entry, but agents effective after RSV infection is established are required. The aim of study is to investigate the effects of late therapeutic intervention with a novel inhaled RSV polymerase inhibitor, PC786, on RSV infection in human airway epithelium. EXPERIMENTAL APPROACH: Air liquid interface (ALI) cultured bronchial or small airway epithelium was infected with RSVA2...
March 26, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29579124/correction-peripheral-organs-of-dengue-fatal-cases-present-strong-pro-inflammatory-response-with-participation-of-ifn-gamma-tnf-alpha-and-rantes-producing-cells
#14
Tiago F Póvoa, Edson R A Oliveira, Carlos A Basílio-de-Oliveira, Gerard J Nuovo, Vera L A Chagas, Natália G Salomão, Ada Maria de Barcelos Alves, Ester M Mota, Marciano V Paes
[This corrects the article DOI: 10.1371/journal.pone.0168973.].
2018: PloS One
https://www.readbyqxmd.com/read/29563120/platelet-hmgb1-is-required-for-efficient-bacterial-clearance-in-intra-abdominal-bacterial-sepsis-in-mice
#15
Hui Zhou, Meihong Deng, Yingjie Liu, Chenxuan Yang, Rosemary Hoffman, Jingjiao Zhou, Patricia A Loughran, Melanie J Scott, Matthew D Neal, Timothy R Billiar
Thrombocytopenia impairs host defense and hemostasis in sepsis. However, the mechanisms of how platelets regulate host defense are not fully understood. High-mobility group box 1 (HMGB1), a danger-associated molecular pattern protein, is released during infection and contributes to the pathogenesis of sepsis. Platelets express HMGB1, which is released on activation and has been shown to play a critical role in thrombosis, monocyte recruitment, and neutrophil extracellular trap (NET) production. However, the contribution of platelet HMGB1 to host defense is unknown...
March 27, 2018: Blood Advances
https://www.readbyqxmd.com/read/29558694/identification-of-ccl5-rantes-as-a-novel-contraction-reducible-myokine-in-mouse-skeletal-muscle
#16
Yuri Ishiuchi, Hitoshi Sato, Narumi Komatsu, Hideo Kawaguchi, Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihara, Taku Nedachi
Skeletal muscle is an endocrine organ that secretes several proteins, which are collectively termed myokines. Although many studies suggest that exercise regulates myokine secretion, the underlying mechanisms remain unclear and all the exercise-dependent myokines have not yet been identified. Therefore, in this study, we attempted to identify novel exercise-dependent myokines by using our recently developed in vitro contractile model. Differentiated C2C12 myotubes were cultured with or without electrical pulse stimulation (EPS) for 24 h to induce cell contraction, and the myokines secreted in conditioned medium were analyzed using a cytokine array...
March 17, 2018: Cytokine
https://www.readbyqxmd.com/read/29555588/cappariloside-a-shows-antiviral-and-better-anti-inflammatory-effects-against-influenza-virus-via-regulating-host-ifn-signaling-in-vitro-and-vivo
#17
Zhengtu Li, Junling Zhao, Hongxia Zhou, Li Li, Yuyang Ding, Jing Li, Beixian Zhou, Haiming Jiang, Nanshan Zhong, Wenhui Hu, Zifeng Yang
AIMS: This study aimed to evaluate the efficacy and mechanisms of Cappariloside A, a chemically synthesized compound, against virus and inflammation induced by influenza virus. MAIN METHODS: The inhibitory activity of Cappariloside A against influenza virus was determined by plaque assay and cytopathic effect inhibition assay. Quantitative real-time PCR, enzyme-linked immunosorbent assay and Bio-Plex methods were used to quantify cytokine and chemokine expression profiles...
March 16, 2018: Life Sciences
https://www.readbyqxmd.com/read/29554045/adenosine-lidocaine-and-mg2-alm-resuscitation-fluid-protects-against-experimental-traumatic-brain-injury
#18
Hayley L Letson, Geoffrey P Dobson
BACKGROUND: Currently no drug therapy prevents secondary injury progression after TBI. Our aim was to investigate the effects of small-volume intravenous adenosine, lidocaine and Mg (ALM) resuscitation fluid after moderate-TBI in a rat fluid-percussion injury model. METHODS: Anesthetized, mechanically-ventilated male Sprague-Dawley rats (449±5g) were randomly assigned to one of four groups: 1) Sham (craniotomy without TBI), 2) No-Treatment, 3) Saline-controls or 4) ALM therapy (all n=16)...
March 16, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29548996/immune-and-metabolic-alterations-in-first-episode-psychosis-fep-patients
#19
Luisella Bocchio Chiavetto, Roberta Zanardini, Sarah Tosato, Mariacarla Ventriglia, Clarissa Ferrari, Chiara Bonetto, Antonio Lasalvia, Franco Giubilini, Angelo Fioritti, Francesca Pileggi, Michela Pratelli, Michele Pavanati, Angela Favaro, Giovanni De Girolamo, Giovanni Battista Frisoni, Mirella Ruggeri, Massimo Gennarelli
The molecular underpinnings associated to first episode psychosis (FEP) remains to be elucidated, but compelling evidence supported an association of FEP with blood alterations in biomarkers related to immune system, growth factors and metabolism regulators. Many of these studies have not been already confirmed in larger samples or have not considered the FEP diagnostic subgroups. In order to identify biochemical signatures of FEP, the serum levels of the growth factors BDNF and VEGF, the immune regulators IL-1RA, IL-6, IL-10 and IL-17, RANTES/CCL5, MIP-1b/CCL4, IL-8 and the metabolic regulators C-peptide, ghrelin, GIP, GLP-1, glucagon, insulin, leptin, PAI-1, resistin and visfatin were analysed in 260 subjects collected in the GET UP project...
March 13, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29532432/the-ranting-of-mr-schafer-finding-meaning-in-life
#20
EDITORIAL
Fabrizia Faustinella
No abstract text is available yet for this article.
March 12, 2018: Academic Psychiatry
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