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https://www.readbyqxmd.com/read/27909304/transmission-of-multiple-hiv-1-subtype-c-transmitted-founder-viruses-into-the-same-recipients-was-not-determined-by-modest-phenotypic-differences
#1
Hongshuo Song, Bhavna Hora, Elena E Giorgi, Amit Kumar, Fangping Cai, Tanmoy Bhattacharya, Alan S Perelson, Feng Gao
A severe bottleneck exists during HIV-1 mucosal transmission. However, viral properties that determine HIV-1 transmissibility are not fully elucidated. We identified multiple transmitted/founder (T/F) viruses in six HIV-1-infected subjects by analyzing whole genome sequences. Comparison of biological phenotypes of different T/F viruses from the same individual allowed us to more precisely identify critical determinants for viral transmissibility since they were transmitted under similar conditions. All T/F viruses used coreceptor CCR5, while no T/F viruses used CXCR4 or GPR15...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895119/partial-agonist-and-biased-signaling-properties-of-the-synthetic-enantiomers-j113863-ucb35625-at-chemokine-receptors-ccr2-and-ccr5
#2
Jenny Corbisier, Alexandre Huszagh, Céline Galés, Marc Parmentier, Jean-Yves Springael
Biased agonism at G protein coupled receptors constitutes a promising area of research for the identification of new therapeutic molecules. In this study, we identified two novel biased ligands for the chemokine receptors CCR2 and CCR5 and characterized their functional properties. We showed that J113863 and its enantiomer UCB35625, initially identified as high-affinity antagonists for CCR1 and CCR3, also bind with low affinity to the closely related receptors CCR2 and CCR5. Binding of J113863 and UCB35625 to CCR2 or CCR5 resulted in the full or partial activation of the three Gi proteins and the two Go isoforms...
November 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27878757/targeting-ccr3-to-reduce-amyloid-%C3%AE-production-tau-hyperphosphorylation-and-synaptic-loss-in-a-mouse-model-of-alzheimer-s-disease
#3
Chunyan Zhu, Bing Xu, Xiaohong Sun, Qiwen Zhu, Yi Sui
The majority of Alzheimer's disease (AD) patients have a late onset, and chronic neuroinflammation, characterized by glial activation and secretion of pro-inflammatory cytokines and chemokines, plays a role in the pathogenesis of AD. The chemokine CCL11 has been shown to be a causative factor of cognitive decline in the process of aging, but little is known whether it is involved in the pathogenesis of AD. In the present study, we showed that CCR3, the receptor for CCL11, was expressed by hippocampal neurons and treatment of primary hippocampal neuronal cultures (14 days in vitro) with CCL11 resulted in activation of cyclin-dependent kinase 5 and glycogen synthase kinase-3β, associated with elevated tau phosphorylation at multiple sites...
November 23, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27866540/-the-study-of-the-eosinophil-cd34-progenitor-cells-differentiation-mechanism-of-model-rats-with-occupational-asthma-and-the-intervention-of-warm-and-tonifying-kidney-yang-decoction
#4
Z Y Hu, Y M Jia, S J Wang, J Y Han, T Yu
Objective: To investigate the mechanism of CD34(+) progenitor cell differentiation in rat by observing the change relations between the eosinophils (EOS) and the content of Eotaxin and IL-5 in blood and the CD34(+)/CCR3(+), CD34(+)/IL-5Rα+ in bone marrow after occupational asthma (OA) model rats are simulated, and to observe the effect of WTKYD Trraitional Chinese Medicine intervention. Methods: A total of 40 healthy male SD model rats (200~250 g weight) were randomly divided into model contrast Group, prednisone acetate intervention Group, WTKYD+1/2 prednisone acetate intervention Group and WTKYD intervention Group, 10 in each group, and set a Group for blank contrast...
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27832807/sex-specific-variation-in-signaling-pathways-and-gene-expression-patterns-in-human-leukocytes-in-response-to-endotoxin-and-exercise
#5
Asghar Abbasi, Rodolfo de Paula Vieira, Felix Bischof, Michael Walter, Masoud Movassaghi, Nicole C Berchtold, Andreas M Niess, Carl W Cotman, Hinnak Northoff
BACKGROUND: While exercise effects on the immune system have received increasing attention in recent years, it remains unclear to what extent gender and fluctuations in sex hormones during menstrual cycle influence immunological responses to exercise. METHODS: We investigated mRNA changes induced through exhaustive exercise (half-marathon; pre-exercise and post-exercise [30 min, 3 h, 24 h] on whole blood cultures ± lipopolysaccharide [LPS] [1 h]) with a specific focus on sex differences (men vs women in luteal phase) as an extension of our previous study...
November 10, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27830077/corrigendum
#6
(no author information available yet)
[This corrects the article DOI: 10.1002/ccr3.493.].
November 2016: Clinical Case Reports
https://www.readbyqxmd.com/read/27825045/therapeutic-effects-of-rosmarinic-acid-on-airway-responses-in-a-murine-model-of-asthma
#7
Zhengmin Liang, Haiying Nie, Yangfeng Xu, Jianbo Peng, Yun Zeng, Yingyi Wei, Xuemei Wen, Jiaming Qiu, Weiting Zhong, Xuming Deng, Jiakang He
Rosmarinic acid (RA) is an active component of a traditional Chinese herbal medicine. Previously, we reported that RA exerted a strong anti-inflammatory effect in a mouse acute lung injury model. Therefore, we hypothesized that RA might also have potential therapeutic effects in a murine model of asthma. In this study, we aimed to evaluate the anti-asthmatic activity of RA and explored its possible molecular mechanisms of action. Female BALB/c mice that had been sensitized to and challenged with ovalbumin (Ova) were treated with RA (20mg/kg) 1h after challenge...
November 5, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27822494/high-content-genome-wide-rnai-screen-reveals-ccr3-as-a-key-mediator-of-neuronal-cell-death
#8
Jianmin Zhang, Huaishan Wang, Omar Sherbini, Emily Ling-Lin Pai, Sung-Ung Kang, Ji-Sun Kwon, Jia Yang, Wei He, Hong Wang, Stephen M Eacker, Zhikai Chi, Xiaobo Mao, Jinchong Xu, Haisong Jiang, Shaida A Andrabi, Ted M Dawson, Valina L Dawson
Neuronal loss caused by ischemic injury, trauma, or disease can lead to devastating consequences for the individual. With the goal of limiting neuronal loss, a number of cell death pathways have been studied, but there may be additional contributors to neuronal death that are yet unknown. To identify previously unknown cell death mediators, we performed a high-content genome-wide screening of short, interfering RNA (siRNA) with an siRNA library in murine neural stem cells after exposure to N-methyl-N-nitroso-N'-nitroguanidine (MNNG), which leads to DNA damage and cell death...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27820933/secretoglobin-superfamily-protein-scgb3a2-alleviates-house-dust-mite-induced-allergic-airway-inflammation-in-mice
#9
Mitsuhiro Yoneda, Lei Xu, Hiroaki Kajiyama, Shuko Kawabe, Jorge Paiz, Jerrold M Ward, Shioko Kimura
BACKGROUND: Secretoglobin (SCGB) 3A2, a novel, lung-enriched, cytokine-like, secreted protein of small molecular weight, was demonstrated to exhibit various biological functions including anti-inflammatory, antifibrotic and growth-factor activities. Anti-inflammatory activity was uncovered using the ovalbumin-induced allergic airway inflammation model. However, further validation of this activity using knockout mice in a different allergic inflammation model is necessary in order to establish the antiallergic inflammatory role for this protein...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27815198/comparative-immunity-of-salmo-salar-and-oncorhynchus-kisutch-during-infestation-with-the-sea-louse-caligus-rogercresseyi-an-enrichment-transcriptome-analysis
#10
Valentina Valenzuela-Muñoz, Sebastian Boltaña, Cristian Gallardo-Escárate
Caligus rogercresseyi, an ectoparasite affecting the Chilean salmon industry, can cause immunosuppression and physiological stress in farmed fish. Interestingly, coho salmon (Oncorhynchus kisutch) are notably resistant to infestation, whereas Atlantic salmon (Salmo salar) are phenotypically more susceptible to sea lice. However, comparative studies on immune responses to C. rogercresseyi have not been conducted. In this study, Illumina sequencing was conducted to evaluate head kidney and skin samples taken 7 and 14 days post-infestation, yielding a total of 1492 and 1522 contigs annotated to immune-related genes for Atlantic and coho salmon, respectively...
December 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27776524/pulsed-high-dose-dexamethasone-modulates-th1-th2-chemokine-imbalance-in-immune-thrombocytopenia
#11
Zongtang Liu, Meiying Wang, Shufen Zhou, Ji Ma, Yan Shi, Jun Peng, Ming Hou, Chengshan Guo
BACKGROUND: Chemokines and chemokine receptors play important roles in autoimmune diseases; however, their role in immune thrombocytopenia (ITP) is unclear. High-dose dexamethasone (HD-DXM) may become a first-line therapy for adult patients with ITP, but the effect of HD-DXM on chemokines in ITP patients is unknown. Our aim was to investigate the mechanism of pulsed HD-DXM for management of ITP, specifically regarding the chemokine pathways. METHODS: Th1-/Th2-associated chemokine and chemokine receptor profiles in ITP patients before and after pulsed HD-DXM was studied...
October 24, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27736777/genome-wide-association-study-for-cell-mediated-response-of-dogs-naturally-infected-by-leishmania-infantum
#12
L F S Batista, Y T Utsunomiya, T B F da Silva, R A Dias, T Y Tomokane, A D Pacheco, V L R da Matta, F T Silveira, M Marcondes, C M Nunes, M D Laurenti
A genome-wide association study (GWAS) could unravel the complexity of the cell-mediated immunity (CMI) to canine leishmaniasis (CanL). Thereby we committed to scan 110,165 single-nucleotide polymorphisms (SNPs) aiming to identify chromosomal regions associated to leishmanin skin test (LST), lymphocyte proliferation assay (LPA) and cytokines responses to further understanding the role played by the CMI in the outcome of the natural Leishmania infantum infection in 189 dogs. Based on LST and LPA, four CMI profiles were identified (LST-/LPA-, LST+/LPA-, LST-/LPA+ and LST+/LPA+), which were not associated to subclinical infected or diseased dogs...
October 10, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27693537/resveratrol-treatment-attenuates-chemokine-receptor-expression-in-the-btbr-t-tf-j-mouse-model-of-autism
#13
Saleh A Bakheet, Mohammad Zeed Alzahrani, Ahmed Nadeem, Mushtaq Ahmad Ansari, Khairy M A Zoheir, Sabry M Attia, Laila Yousef Al-Ayadhi, Sheikh Fayaz Ahmad
Autism is a neurodevelopmental disorder categorized by qualitative impairments in social interaction, communication, and repetitive stereotypic behavior. Emerging evidence increasingly suggests that chemokine receptors have a pivotal role in the central nervous system and are involved in the pathogenesis of numerous neuroinflammatory diseases. Resveratrol is widely used to treat neurodegenerative diseases, but its effect on autism has not been investigated. We investigated the effect of resveratrol (20 and 40mg/kg) in the spleen and brain tissues of BTBR T+tf/J (BTBR) and C57BL/6J (B6) mice as well as on the C-C chemokine receptor (CCR) and C-X-C motif chemokine receptor (CXCR) (CCR3(+), CCR5(+), CCR7(+) and CCR9(+), CXCR3(+) and CXCR5(+)) in cluster of differentiation 4-positive (CD4(+)) T cells in the spleen...
December 2016: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/27688600/doxycycline-and-benznidazole-reduce-the-profile-of-th1-th2-and-th17-chemokines-and-chemokine-receptors-in-cardiac-tissue-from-chronic-trypanosoma-cruzi-infected-dogs
#14
Guilherme de Paula Costa, Laís Roquete Lopes, Maria Cláudia da Silva, Aline Luciano Horta, Washington Martins Pontes, Cristiane M Milanezi, Paulo Marcos da Mata Guedes, Wanderson Geraldo de Lima, Richard Schulz, João Santana da Silva, Andre Talvani
Chemokines (CKs) and chemokine receptors (CKR) promote leukocyte recruitment into cardiac tissue infected by the Trypanosoma cruzi. This study investigated the long-term treatment with subantimicrobial doses of doxycycline (Dox) in association, or not, with benznidazole (Bz) on the expression of CK and CKR in cardiac tissue. Thirty mongrel dogs were infected, or not, with the Berenice-78 strain of T. cruzi and grouped according their treatments: (i) two months after infection, Dox (50 mg/kg) 2x/day for 12 months; (ii) nine months after infection, Bz (3,5 mg/kg) 2x/day for 60 days; (iii) Dox + Bz; and (iv) vehicle...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27685197/follow-up-of-venom-immunotherapy-on-flow-cytometry-and-definition-of-a-protective-index
#15
Jean Sainte-Laudy, François Touraine, Delphine Cluzan, François Belle Moudourou
BACKGROUND: A major problem of venom-specific immunotherapy (VIT) is the absence of reliable parameters for deciding treatment discontinuation. AIM OF THE STUDY: Intracutaneous tests (ICTs), the basophil activation test (BAT), specific IgEs (sIgEs) and blocking factor (BF) activity were measured during VIT. We made an evaluation by means of a protective index (PI) including ICT, BAT and BF values. MATERIAL AND METHODS: A population of 45 patients who had experienced a systemic reaction after an insect sting were tested before VIT (T0), at 1 week (T1w), at 10 weeks (T10w) and at 21 weeks (T21w), and, for a subgroup of 17 patients, at 3-5 years (T3-5y)...
September 30, 2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27664933/an-emerging-role-for-eotaxins-in-neurodegenerative-disease
#16
Amanda K Huber, David A Giles, Benjamin M Segal, David N Irani
Eotaxins are C-C motif chemokines first identified as potent eosinophil chemoattractants. They facilitate eosinophil recruitment to sites of inflammation in response to parasitic infections as well as allergic and autoimmune diseases such as asthma, atopic dermatitis, and inflammatory bowel disease. The eotaxin family currently includes three members: eotaxin-1 (CCL11), eotaxin-2 (CCL24), and eotaxin-3 (CCL26). Despite having only ~30% sequence homology to one another, each was identified based on its ability to bind the chemokine receptor, CCR3...
September 21, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27649282/the-chemokines-secretion-and-the-oxidative-stress-are-targets-of-low-level-laser-therapy-in-allergic-lung-inflammation
#17
Jorge Luis Costa Carvalho, Auriléia Aparecida de Brito, Ana Paula Ligeiro de Oliveira, Hugo Caire de Castro Faria Neto, Thiago Martini Pereira, Regiane Albertini de Carvalho, Elen Anatriello, Flávio Aimbire
Recent studies show that low-level laser therapy (LLLT) has an important anti-inflammatory action in acute lung inflammation. The present work explored if laser therapy is able to antagonize eosinophils and allergic inflammation induced by oxidative stress in Balb/c mice. Forty-eight hours after challenge, the leukocyte counting, ROS and nitrite/nitrate level, RANTES, CCL3, CCL8 as well as eotaxins were measured in the bronchoalveolar lavage fluid (BALF) of laser-treated mice or not. Into the lung, some chemokines receptors, the iNOS activity and mRNA expression, and the activities of superoxide dismutase (SOD), catalase, gluthatione, NADPH oxidase activities and thiobarbituric acid reactive species (T-Bars) were measured...
September 20, 2016: Journal of Biophotonics
https://www.readbyqxmd.com/read/27621211/macrophages-and-cardiac-fibroblasts-are-the-main-producers-of-eotaxins-and-regulate-eosinophil-trafficking-to-the-heart
#18
Nicola L Diny, Xuezhou Hou, Jobert G Barin, Guobao Chen, Monica V Talor, Julie Schaub, Stuart D Russell, Karin Klingel, Noel R Rose, Daniela Čiháková
Cardiac manifestations are a major cause of morbidity and mortality in patients with eosinophil-associated diseases. Eosinophils are thought to play a pathogenic role in myocarditis. We investigated the pathways that recruit eosinophils to the heart using a model of eosinophilic myocarditis, in which experimental autoimmune myocarditis (EAM) is induced in IFNγ(-/-) IL-17A(-/-) mice. Two conditions are necessary for efficient eosinophil trafficking to the heart: high eotaxin (CCL11, CCL24) expression in the heart and expression of the eotaxin receptor CCR3 by eosinophils...
September 12, 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27580990/chemokine-c-c-motif-ligand-28-and-its-receptor-ccr10-expression-and-function-at-the-maternal-conceptus-interface-in-pigs
#19
Yohan Choi, Heewon Seo, Jisoo Han, Inkyu Yoo, Jinyoung Kim, Hakhyun Ka
Many chemokines are present at the maternal-fetal interface and play important roles in the establishment and maintenance of pregnancy. Our study demonstrates that a chemokine, chemokine (C-C motif) ligand 28 (CCL28), is expressed in the uterine endometrium during early pregnancy in pigs. Thus, we investigated expression of CCL28 and its receptors, chemokine (C-C motif) receptor type 3 (CCR3) and 10 (CCR10), in the uterine endometrium during the estrous cycle and pregnancy and the function of CCL28 at the maternal-fetal interface during early pregnancy...
August 31, 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27495116/upregulated-expression-of-ccr3-in-rheumatoid-arthritis-and-ccr3-dependent-activation-of-fibroblast-like-synoviocytes
#20
Xin Liu, Huiyun Zhang, Xin Chang, Jirong Shen, Wenjiao Zheng, Yanan Xu, Junling Wang, Wei Gao, Shaoheng He
It is recognized that CC chemokine receptor 3 (CCR3) is associated with numerous inflammatory conditions and fibroblast-like synoviocyte (FLS) invasiveness correlates with articular damage in rheumatoid arthritis (RA). However, little is known of the expression and action of CCR3 on FLS in RA. In the present study, we investigated the expression of CCR3 on dispersed synovial tissue and peripheral blood cells in RA and influence of eotaxin-1 on FLS functions by using flow cytometry analysis, FLS challenge, and real-time PCR techniques...
August 5, 2016: Cell Biology and Toxicology
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