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Elastomeric infusion pump

Ellen L Cusano, Raafi Ali, Michael B Sawyer, Carole R Chambers, Patricia A Tang
Purpose Elastomeric pumps are used to administer 46-hour infusions of 5-fluorouracil (5FU). Baxter suggests patients visually monitor their pumps to ensure that infusions are proceeding correctly. This can be confusing and lead to concerns about under- or over-dosing. Baxter has not considered weighing pumps as a validated method for monitoring. This study aims to validate weighing as a more accurate method for patients and healthcare professionals, and describe real life Baxter Infusor™ variability. Methods Patients who had been started on a 46-hour 5FU infusion returned to the clinic approximately 24 h after starting treatment...
January 1, 2017: Journal of Oncology Pharmacy Practice
Anuvrat Chopra, Jeff Hurren, Susan Szpunar, Stephanie B Edwin
OBJECTIVE: To assess the effectiveness of local anesthesia, delivered via elastomeric pump to manage pain in patients undergoing cardiothoracic surgery. METHODS: A retrospective, comparative analysis evaluating adult cardiothoracic surgery patients (by median sternotomy) who received continuous infusion bupivacaine + traditional methods of pain control (N = 100) or traditional pain control alone (N = 100) from July 2011-October 2013. The primary efficacy end point was total postoperative opioid requirements for 96 hours following surgery...
January 10, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Carole R Chambers, Mica Pabia, Michael Sawyer, Patricia A Tang
PURPOSE: Elastomeric pumps are used to infuse a 46-h fluorouracil protocol and patients are asked to visually inspect the pump daily. The pump has a variability of ±10% and there are additional patient variables that can increase this. The feasibility of weighing the pump rather than a visual inspection along with the secondary objective to confirm the pump's variability in real world conditions was undertaken. METHODS: Empty pumps were weighed using both pharmacy and kitchen scales...
June 29, 2016: Journal of Oncology Pharmacy Practice
Marco Faccini, Roberto Leone, Sibilla Opri, Rebecca Casari, Chiara Resentera, Laura Morbioli, Anita Conforti, Fabio Lugoboni
Despite the first reports concerning benzodiazepine dependence being published in the early 1960s literature, the risk of benzodiazepine addiction is still greatly debated. The severe discomfort and life threatening complications usually experienced by long-term benzodiazepine users who suddenly interrupt benzodiazepine intake have led to the development of several detoxification protocols. A successful strategy used by our Addiction Unit is abrupt benzodiazepine cessation by administering flumazenil slow subcutaneous infusion (FLU-SSI) with an elastomeric pump...
October 2016: Journal of Psychopharmacology
Arunangshu Ghoshal, Naveen Salins, Anuja Damani, Jayita Deodhar, M A Muckaden
Malignant bowel obstruction (MBO) is commonly seen in patients with advanced abdominal cancers. The incidence of pediatric MBO in a patient with Burkitt's lymphoma and ataxia telangiectasia is rare, with no published case reports till now. Conservative management of inoperable MBO results in relief of symptoms and improves quality of life. An 11-year-old boy with Burkitt's lymphoma and ataxia telangiectasia was referred to pediatric palliative care with MBO. The objective of this report is to demonstrate conservative management of pediatric MBO using continuous ambulatory drug delivery system...
2016: Journal of Pain & Palliative Care Pharmacotherapy
Peter Iliev, Tarun Bhalla, Joseph D Tobias
BACKGROUND: The Ambu Smart-Infuser Pain Pump and the On-Q Pump with Select-a-Flow Variable Rate Controller are elastomeric devices with a flow regulator that controls the rate of infusion of a local anesthetic agent through a peripheral catheter. As a safety evaluation, we evaluated the infusion characteristics of these two devices when filled with manufacturer recommended standard volumes and when overfilled with a volume 50% in excess of that which is recommended. METHODS: Nineteen disposable devices from the two manufacturers were used in this study...
April 2016: Paediatric Anaesthesia
Franco Rabbia, Antonio D'Avolio, GiamPaolo Bernini, Chiara Fulcheri, Amedeo De Nicolò, Elena Berra, Rosa Maria Bruno, Paolo Mulatero, Stefano Taddei, Franco Veglio
No abstract text is available yet for this article.
March 2016: Hypertension
Sisir Bhattacharya, Satish Parekh, Mahendra Dedhiya
The objective of this study was to determine in-use stability of ceftaroline fosamil infusion solution of concentrations up to 12 mg/mL in elastomeric home infusion system prefilled with 0.9% Sodium Chloride Injection USP or 5% Dextrose Injection USP and MINI-BAG Plus Container delivery devices prefilled with 0.9% sodium chloride injection. In-use ceftaroline fosamil infusion solution (12 mg/mL) was prepared for elastomeric home infusion systems (Homepump Eclipse, Baxter Intermate, and AccuRx Elastomeric Pump) pre-filled with either 0...
September 2015: International Journal of Pharmaceutical Compounding
Argyro Fassoulaki, Emilia Vassi, Dimitrios Korkolis, Marianna Zotou
Wound infusion with local anesthetics has been used for postoperative pain relief with variable results. This randomized, controlled, double-blind clinical trial examines the effect of ropivacaine infusion on pain after laparoscopic cholecystectomy. A total of 110 patients were randomly assigned to 2 groups. After induction of anesthesia a 75-mm catheter was inserted subcutaneously and connected to an elastomeric pump containing either 0.75% ropivacaine (ropivacaine group) or normal saline (control group) for 24 hours postoperatively...
February 2016: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Patrick Sand, Traci Aladeen, Paul Kirkegaard, Dennis LaChance, Christine Slover
BACKGROUND: VIBATIV is a once-daily, injectable lipoglycopeptide antibiotic approved in the U.S. for the treatment of hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP) caused by susceptible isolates of Staphylococcus aureus when alternative treatments are not suitable. In addition, VIBATIV is approved in the U.S. for the treatment of adult patients with complicated skin & skin structure infections (cSSSI) caused by susceptible isolates of Gram-positive bacteria, including Staphylococcus aureus, both methicillin-susceptible (MSSA) and methicillin-resistant (MRSA) strains...
December 2015: Current Therapeutic Research, Clinical and Experimental
F Coluzzi, C Mattia, G Savoia, P Clemenzi, R Melotti, R B Raffa, J V Pergolizzi
OBJECTIVE: Despite established standards, effective treatments, and evidence-based guidelines, postoperative pain control in Italy and other parts of the world remains suboptimal. Pain control has been recognized as a fundamental human right. Effective treatments exist to control postsurgical pain. Inadequate postoperative analgesia may prolong the length of hospital stays and may adversely impact outcomes. MATERIALS AND METHODS: The same multiple-choice survey administered at the SIAARTI National Congress in Perugia in 2006 (n=588) was given at the SIAARTI National Congress in Naples, Italy in 2012 (n=635)...
November 2015: European Review for Medical and Pharmacological Sciences
Ryota Hase, Shunsuke Uno, Kazuyasu Miyoshi, Koji Fujita, Hiroyuki Suzuki, Daisuke Suzuki, Takahiro Mikawa, Kiyoharu Muranaka, Naoto Hosokawa
In 2014, we reported the first trial based on outpatient parenteral antimicrobial therapy (OPAT) with continuous infusions in Japan. Following this, we found many patients who were eligible for OPAT but could not undertake it owing to difficulties in accessing the clinic daily. To overcome this problem, we created a model in collaboration with visiting nursing stations and started providing OPAT with the services. We report herein on a summary of the investigation of the first 10 patients treated under this model...
September 2015: Kansenshōgaku Zasshi. the Journal of the Japanese Association for Infectious Diseases
Michael T Kenes, Mandy C Leonard, Seth R Bauer, Marcia J Wyman
PURPOSE: The duration of analgesia and comparative efficacy of liposomal bupivacaine and an elastomeric bupivacaine pump in a diverse surgical population were determined. METHODS: A retrospective cohort study was conducted to evaluate patient outcomes following liposomal bupivacaine and elastomeric bupivacaine pump use from January through June 2013. The primary objective of the study was to evaluate 24-hour postoperative opioid use (in morphine equivalents). RESULTS: Sixty-seven liposomal bupivacaine and 262 elastomeric bupivacaine pump patients were included...
December 1, 2015: American Journal of Health-system Pharmacy: AJHP
Katsuki Muneoka, Yoshio Shirai, Junkichi Kanda, Masataka Sasaki, Toshifumi Wakai, Hiroyuki Wakabayashi
A 6 1-year-old man with unresectable multiple hepatic metastases after resection of sigmoid colon carcinoma was treated with irinotecan and infused 5-fluorouracil(5-FU)plus Leucovorin(FOLFIRI). Since the levels of tumor markers increased, the 5-FU dose was increased from 2,700 to 3,000mg/m2 using a Jackson-type pump and an extended infusion time of 53 hours. The blood level of 5-FU was 507 ng/mL 16hours after starting the infusion. The pump was then changed to a bottle-type pump with the same dose of 3,000mg/m2...
October 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
A Chaudhry, S Hallam, A Chambers, A K Sahu, S Govindarajulu, S Cawthorn
INTRODUCTION: Postoperative pain after breast surgery is one of the major factors contributing to delay in mobilisation and prolonged hospital stay. A retrospective analysis was performed of patients undergoing skin sparing mastectomy and insertion of a subpectoral implant. The aim was to determine whether the use of an elastomeric local anaesthetic pump improved pain control and length of stay. METHODS: Twenty-five consecutive patients undergoing the above procedure were sited with an elastomeric local anaesthetic infusion pump intraoperatively, in addition to standard regular and pro re nata analgesia...
July 2015: Annals of the Royal College of Surgeons of England
Gennadiy Fuzaylov, Tara L Kelly, Cheryl Bline, Alexander Dunaev, Maggie L Dylewski, Daniel N Driscoll
OBJECTIVE: Post-operative pain can significantly affect a patient's ability to recover following surgery. In this study we introduced the concept of post-operative pain evaluation of burn patients as well as a technique for placement and use of subcutaneous catheters for continuous infusion of local anesthetic to provide analgesia following skin harvest from the lateral thigh in a hospital in resource-restricted country--Ukraine. METHODS: A total of 109 patients were enrolled in this study...
December 2015: Burns: Journal of the International Society for Burn Injuries
Luiz Eduardo Imbelloni, Neli Lucena
Ankylosing spondylitis is characterized by progressive ossification of the spinal column with resultant stiffness. Ankylosing spondylitis can present significant challenges to the anaesthetist as a consequence of the potential difficult airway and performing neuraxial blockade. We describe a case of intubation with lighted stylet, and use of the continuous lumbosacral plexus for THA and postoperative analgesia with an elastomeric pump. Key words: Airways difficult anticipated, anesthesia, ankoylosing spondylitis, arthroplasty, conduction, continuous lumbosacral plexus, hip, infusion pumps, intubation awake, replacement...
January 2015: Anesthesia, Essays and Researches
Alan Abdulla, Roelof W F van Leeuwen, Aurelia H M de Vries Schultink, Birgit C P Koch
Infections of the respiratory tract with Pseudomonas aeruginosa in cystic fibrosis patients are frequently treated with colistimethate sodium (CMS). For the intravenous administration of CMS a disposable elastomeric pump is a convenient option. To date, there are no data available on the chemical stability of CMS solutions stored in elastomeric pumps. We evaluated the chemical stability of 0.8 mg/mL solutions of CMS by measuring the degradation over a period of 7 days. Test samples were prepared by diluting CMS with saline solution (0...
2015: International Journal of Pharmaceutics
Alfonso Fiorelli, Anna Cecilia Izzo, Elisabetta Maria Frongillo, Assunta Del Prete, Giovanni Liguori, Emilio Di Costanzo, Giovanni Vicidomini, Mario Santini
OBJECTIVES: Continuous wound infusion of local anaesthetics has been successfully applied for postoperative pain control in several procedures but, surprisingly, it is underused in thoracic surgery. We aimed to investigate the effects of wound analgesia associated with systemic patient-controlled analgesia in patients undergoing lung cancer resection with muscle-sparing thoracotomy. METHODS: Sixty consecutive patients undergoing lung cancer resection via standard muscle-sparing thoracotomy were randomized into two groups (wound analgesia and placebo groups)...
January 2016: European Journal of Cardio-thoracic Surgery
A Mujal, J Sola, M Hernandez, M-A Villarino, M-L Machado, M Baylina, J Tajan, J Oristrell
Home intravenous antibiotic therapy is an alternative to hospital admission for moderately severe infections. However, few studies have analyzed its safety and effectiveness in the treatment of infections caused by multidrug-resistant bacteria. The purpose of this study is to analyze the safety and effectiveness of home intravenous antibiotic therapy in multidrug-resistant bacterial infections. We analyzed prospectively all patients admitted to our service who underwent home intravenous antibiotic therapy during the period 2008-2012...
June 2015: European Journal of Clinical Microbiology & Infectious Diseases
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