Juncheng Cai, Siyuan Wang, Haoyun Du, Lei Fan, WeiFeng Yuan, Qiufan Xu, Jinlian Ren, Qiuyan Lin, Bin Xiang, Chan Ding, Tao Ren, Libin Chen
Newcastle disease (ND), caused by the Newcastle disease virus (NDV), is a highly virulent infectious disease of poultry. Virulent NDV can cause severe autophagy and inflammation in host cells. While studies have shown a mutual regulatory relationship between autophagy and inflammation, this relationship in NDV infection remains unclear. This study confirmed that NDV infection could trigger autophagy in DF-1 cells to promote cytopathic and viral replication. NDV-induced autophagy was positively correlated with the mRNA levels of inflammatory cytokines such as IL-1β, IL-8, IL-18, CCL-5, and TNF-α, suggesting that NDV-induced autophagy promotes the expression of inflammatory cytokines...
June 5, 2023: Veterinary Research