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"Acid-base"

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https://www.readbyqxmd.com/read/28548685/detection-methods-of-cyprinid-herpesvirus-2-infection-in-silver-crucian-carp-carassius-auratus-gibelio-via-a-porf72-monoclonal-antibody
#1
S Y Kong, Y S Jiang, Q Wang, J F Lu, D Xu, L Q Lu
Cyprinid herpesvirus 2 (CyHV-2) is the main pathogen responsible for causing haematopoietic necrosis disease in Carassius auratus gibelio. Although many nucleic acid-based diagnostic methods have been applied, no stable and sensitive immunological diagnostic approaches have been reported. In this study, to detect CyHV-2 in clinical samples using immunological methods, recombinant ORF72 protein (pORF72), encoded by the CyHV-2 ORF72 gene, was used as a capture antigen to identify blood and tissues infected with CyHV-2...
May 26, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28547292/physiological-implications-of-ocean-acidification-for-marine-fish-emerging-patterns-and-new-insights
#2
REVIEW
Andrew J Esbaugh
Ocean acidification (OA) is an impending environmental stress facing all marine life, and as such has been a topic of intense research interest in recent years. Numerous detrimental effects have been documented in marine fish, ranging from reduced mortality to neurosensory impairment, and the prevailing opinions state that these effects are largely the downstream consequences of altered blood carbon dioxide chemistry caused by respiratory acid-base disturbances. While the respiratory acid-base disturbances are consistent responses to OA across tested fish species, it is becoming increasingly clear that there is wide variability in the degree of downstream impairments between species...
May 25, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28546112/pemphigus-vulgaris-induced-by-5-aminolaevulinic-acid-based-photodynamic-therapy
#3
Qian Zhou, Peiru Wang, Linglin Zhang, Bo Wang, Lei Shi, Uma Keyal, Anil Kumar Bhatta, Guolong Zhang, Xiuli Wang
Pemphigus vulgaris (PV) is an autoimmune disorder resulting from the interaction between autoantibodies and desmoglein. Here, we report a case of PV developed after 5-aminolaevulinic acid-based photodynamic therapy (ALA-PDT). The harmful and deleterious effects of UV radiation on the onset, during course, and perpetuation of PV have been observed for decades. Correlation between reactive oxygen species (ROS) and PV have also been reported. Oxidative proteins, which are modified by ROS, and subsequent production of antibodies by immune system seem to be responsible for PV developed following ALA-PDT...
May 22, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28544521/oral-nucleic-acid-therapy-using-multicompartmental-delivery-systems
#4
REVIEW
Husain Attarwala, Murui Han, Jonghan Kim, Mansoor Amiji
Nucleic acid-based therapeutics has the potential for treating numerous diseases by correcting abnormal expression of specific genes. Lack of safe and efficacious delivery strategies poses a major obstacle limiting clinical advancement of nucleic acid therapeutics. Oral route of drug administration has greater delivery challenges, because the administered genes or oligonucleotides have to bypass degrading environment of the gastrointestinal (GI) tract in addition to overcoming other cellular barriers preventing nucleic acid delivery...
May 24, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28541029/homochiral-mof-as-circular-dichroism-sensor-for-enantioselective-recognition-on-nature-and-chirality-of-unmodified-amino-acids
#5
Yan-Wu Zhao, Yan Wang, Xian-Ming Zhang
Self-assembly of zinc salt with rationally designed chiral ligand, (1R,2R)-2-(pyridine-4-yl carbamoyl) cyclohexanecarboxylic acid (RR-PCCH) generated 2D homochiral metal-organic framework [Zn(RR-PCCHC)2] (HMOF-1) that is composed of DNA-like right-handed double-helix structure. HMOF-1 shows high solvent and thermal stability and is also stable in neutral, weak acidic and weak basic aqueous solution. Emulsified HMOF-1 shows strong inherent circular dichroism (CD) signal in aqueous solution, which can show regular intensity change by induction of amino acids...
May 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28540602/late-conversion-from-tacrolimus-to-a-belatacept-based-immuno-suppression-regime-in-kidney-transplant-recipients-improves-renal-function-acid-base-derangement-and-mineral-bone-metabolism
#6
Kevin Schulte, Clara Vollmer, Vera Klasen, Jan Hinrich Bräsen, Jodok Püchel, Christoph Borzikowsky, Ulrich Kunzendorf, Thorsten Feldkamp
BACKGROUND: Calcineurin inhibitor (CNI)-induced nephrotoxicity and chronic graft dysfunction with deteriorating glomerular filtration rate (GFR) are common problems of kidney transplant recipients. The aim of this study was to analyze the role of belatacept as a rescue therapy in these patients. METHODS: In this retrospective, observational study we investigated 20 patients (10 females, 10 males) who were switched from a CNI (tacrolimus) to a belatacept-based immunosuppression because of CNI intolerance or marginal transplant function...
May 24, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/28540381/lipoic-acid-based-core-cross-linked-micelles-for-multivalent-platforms-design-synthesis-and-application-in-bio-imaging-and-drug-delivery
#7
Jingsheng Huang, Fang Wu, Yunlong Yu, Haolong Huang, Shiyong Zhang, Jingsong You
Natural lipoic acid derived small-molecule amphiphiles self-assemble into micelles in water. The presence of numerous disulfides accumulated in the core makes the micelles readily cross-linked to achieve the establishment of core cross-linked micelles (CCMs). Thanks to the inherent biocompatibility, the resulting lipoic acid based CCMs (LA-CCMs) are good multivalent platforms for biomedical applications.
May 25, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28537512/do-patients-with-a-baseline-clinical-condition-warranting-the-cautious-use-of-parenteral-nutrition-develop-subsequent-metabolic-complications
#8
Diana M Solomon, James M Hollands, Laura A Siemianowski, Colleen E Smith, Richard J Song, Angela L Bingham
BACKGROUND: The American Society for Parenteral and Enteral Nutrition Adult Nutrition Support Core Curriculum describes clinical conditions that warrant cautious use of parenteral nutrition (CCWCPN). The Core Curriculum authors acknowledge there is no evidence for specific criteria suggested for the clinical conditions. Consequently, the purpose of this study was to determine the impact of a baseline CCWCPN on the development of subsequent metabolic complications in patients receiving parenteral nutrition (PN)...
June 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28536712/scaleable-two-component-gelator-from-phthalic-acid-derivatives-and-primary-alkyl-amines-acid-base-interaction-in-the-cooperative-assembly
#9
Ting Su, Kwon Ho Hong, Wannian Zhang, Fei Li, Qiang Li, Fang Yu, Genxiang Luo, Honghe Gao, Yu-Peng He
A series of phthalic acid derivatives (P) with a carbon-chain tail was designed and synthesized as single-component gelators. A combination of the single-component gelator P and a non-gelling additive n-alkylamine A through acid-base interaction brought about a series of novel phase-selective two-component gelators PA. The gelation capabilities of P and PA, and the structural, morphological, thermo-dynamic and rheological properties of the corresponding gels were investigated. A molecular dynamics simulation showed that the H-bonding network in PA formed between the NH of A and the carbonyl oxygen of P altered the assembly process of gelator P...
May 24, 2017: Soft Matter
https://www.readbyqxmd.com/read/28536446/preparation-characterization-and-pharmacokinetics-of-cyadox-nanosuspension
#10
Adeel Sattar, Dongmei Chen, Lishun Jiang, Yuanhu Pan, Yanfei Tao, Lingli Huang, Zhenli Liu, Shuyu Xie, Zonghui Yuan
An increase in number of newly developed synthetic drugs displays bioavailability constraints because of poor water solubility. Nanosuspensions formulation may help to overwhelm these problems by increasing dissolution velocity and saturation solubility. In the present study, cyadox (Cyx) nanosuspension was successfully prepared by recrystallization based on acid-base neutralization combined with high pressure homogenization method using Polyvinylpyrrolidone K30 (PVP) as stabilizer. The nanosuspension had uniform particle distribution, excellent sedimentation rate and redispersibility...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28535516/citrate-anticoagulation-during-continuous-renal-replacement-therapy
#11
Davide Ricci, Laura Panicali, Maria Grazia Facchini, Elena Mancini
During extracorporeal dialysis, some anticoagulation strategy is necessary to prevent the coagulation of blood. Heparin has historically been used as an anticoagulant because of its efficacy combined with low cost. However, a variable incidence of hemorrhagic complications (5-30%) has been documented in patients undergoing continuous renal replacement therapy (CRRT) with heparin as an anticoagulant. Citrate has anticoagulation properties secondary to its ability to chelate calcium, which is necessary for the coagulation cascade...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28534627/highly-stable-and-regenerative-metal-organic-framework-designed-by-multi-walled-divider-installation-strategy-for-detection-of-co-%C3%AE-%C3%AE-ions-and-organic-aromatics-in-water
#12
Kai Xing, Ruiqing Fan, Jiaqi Wang, Siqi Zhang, Kai Feng, Xi Du, Yang Song, Ping Wang, Yulin Yang
MOF-based sensors capable of effectively and stably detecting toxic species in water have attracted huge attention in terms of improving environmental monitoring levels and water quality. Combining the flexibility of structure and modifying of pore surface, a multi-walled divider installation (MWDI) strategy is proposed and used for property enhancement. We herein report three metal-organic frameworks (MOFs) 1-3 based on a C3 symmetry organic phosphonic ligand with topology increased from 3,6-connected to 3,8-connected...
May 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28533371/blue-fluorescent-amino-acid-for-biological-spectroscopy-and-microscopy
#13
Mary Rose Hilaire, Ismail A Ahmed, Chun-Wei Lin, Hyunil Jo, William F DeGrado, Feng Gai
Many fluorescent proteins are currently available for biological spectroscopy and imaging measurements, allowing a wide range of biochemical and biophysical processes and interactions to be studied at various length scales. However, in applications where a small fluorescence reporter is required or desirable, the choice of fluorophores is rather limited. As such, continued effort has been devoted to the development of amino acid-based fluorophores that do not require a specific environment and additional time to mature and have a large fluorescence quantum yield, long fluorescence lifetime, good photostability, and an emission spectrum in the visible region...
May 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28532112/preparations-and-doxorubicin-controlled-release-of-amino-acid-based-redox-ph-dual-responsive-nanomicelles
#14
Yuanyuan Ding, Liping Zhang, Gang Shi, Xinxin Sang, Caihua Ni
Terpolymers of poly (Lysine-co-N, N-Bis (acryloyl) cystamine-co-β-Phenethylamine) (PLBP) were synthesized in one-pot by Michael addition terpolymerization. The terpolymers self-assembled into nano-sized spherical micelles (84-123nm) with narrow distributions. The surface charge of the nanomicelles (NMs) was depended on solution's pH and showed negative values under physiological conditions (pH7.4), which was beneficial for long circulation without non-specific protein adsorption. Doxorubicin (DOX) was effectively loaded into the NMs for controlled release...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532094/electrochemical-sensing-of-doxorubicin-in-unprocessed-whole-blood-cell-lysate-and-human-plasma-samples-using-thin-film-of-poly-arginine-modified-glassy-carbon-electrode
#15
Jafar Soleymani, Mohammad Hasanzadeh, Morteza Eskandani, Maryam Khoubnasabjafari, Nasrin Shadjou, Abolghasem Jouyban
A thin film of poly-arginine fabricated on glassy carbon electrode by one step electrodeposition method is applied for detection of doxorubicin hydrochloride in whole blood, cell lysate, and untreated-plasma samples. Cyclic voltammetry results indicated that the doxorubicin is oxidized via two electrons and two protons at physiological pH (pH=7.4) using poly-arginine thin film modified glassy carbon. More importantly, electrostatic repulsion takes place between the prepared polymer film-modified electrode and selected drug resulting in the signal amplification on oxidation of doxorubicin and lowering its over potential and thereby selective detection of doxorubicin in real samples...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28530505/ingestion-of-sodium-bicarbonate-nahco3-following-a-fatiguing-bout-of-exercise-accelerates-post-exercise-acid-base-balance-recovery-and-improves-subsequent-high-intensity-cycling-time-to-exhaustion
#16
Lewis A Gough, Steven Rimmer, Callum J Osler, Matthew F Higgins
This study evaluated the ingestion of sodium bicarbonate (NaHCO3) on post-exercise acid-base balance recovery kinetics and subsequent high-intensity cycling time to exhaustion. In a counterbalanced, crossover design, nine healthy and active males (age: 23±2 years, height: 179±5 cm, body mass: 74±9 kg, peak mean minute power (WPEAK) 256±45 W, peak oxygen uptake (V̇O2PEAK) 46±8 ml.kg(-1).min(-1)) performed a graded incremental exercise test, two familiarisation and two experimental trials. Experimental trials consisted of cycling to volitional exhaustion (TLIM1) at 100% WPEAK on two occasions (TLIM1 and TLIM2) interspersed by a 90 min passive recovery period...
May 22, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28524033/-procedural-analysis-of-acid-base-balance-disorder-case-serials-in-4-patents
#17
Chunyuan Ma, Guijie Wang
OBJECTIVE: To establish the standardization process of acid-base balance analysis, analyze cases of acid-base balance disorder with the aid of acid-base balance coordinate graph. METHODS: The acid-base balance theory were reviewed systematically on recent research progress, and the important concepts, definitions, formulas, parameters, regularity and inference in the analysis of acid-base balance were studied. The analysis of acid-base balance disordered processes and steps were figured...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28522412/athero-inflammatory-nanotherapeutics-ferulic-acid-based-poly-anhydride-ester-nanoparticles-attenuate-foam-cell-formation-by-regulating-macrophage-lipogenesis-and-reactive-oxygen-species-generation
#18
Rebecca A Chmielowski, Dalia S Abdelhamid, Jonathan J Faig, Latrisha K Petersen, Carol R Gardner, Kathryn E Uhrich, Laurie B Joseph, Prabhas V Moghe
Enhanced bioactive anti-oxidant formulations are critical for treatment of inflammatory diseases, such as atherosclerosis. A hallmark of early atherosclerosis is the uptake of oxidized low density lipoprotein (oxLDL) by macrophages, which results in foam cell and plaque formation in the arterial wall. The hypolipidemic, anti-inflammatory, and antioxidative properties of polyphenol compounds make them attractive targets for treatment of atherosclerosis. However, high concentrations of antioxidants can reverse their anti-atheroprotective properties and cause oxidative stress within the artery...
May 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28521043/nutritional-evaluation-of-conventional-and-increased-protein-reduced-fiber-canola-meal-fed-to-broiler-chickens
#19
M Gorski, C Foran, P Utterback, C M Parsons
Experiments were conducted to evaluate conventional canola meal (Conv CM) and a new increased-protein reduced-fiber CM (Test CM). The Test CM contained higher levels of all digestible amino acids than the Conv CM as determined in 2 precision-fed rooster assays wherein Single Comb White Leghorn roosters were fasted for 24 h and then tube-fed 30 g of Conv CM or Test CM. Excreta were then quantitatively collected for 48 hours. All diets in 2 broiler experiments then were formulated to be equal in AMEn and digestible amino acids based on values from precision-fed rooster assays...
May 17, 2017: Poultry Science
https://www.readbyqxmd.com/read/28516780/dual-colored-carbon-dot-ratiometric-fluorescent-test-paper-based-on-a-specific-spectral-energy-transfer-for-semiquantitative-assay-of-copper-ions
#20
Cui Liu, Dianhua Ning, Cheng Zhang, Zhengjie Liu, Ruilong Zhang, Jun Zhao, Tingting Zhao, Bianhua Liu, Zhongping Zhang
Classical pH test papers are widely used to measure the acid-base degree of media in a qualitative or semiquantitative manner. However, the extension of portable and inexpensive methods to a wide range of analytes so as to eliminate the tediousness of instrumental assays remains unsuccessful. Here, we report a novel kind of dual-colored carbon dot (CD) ratiometric fluorescent test paper for the semiquantitative assay of copper ions (Cu(2+)) by a dose-sensitive color evolution. The preparation of the test paper is based on the following two interesting findings: on the one hand, residual p-phenylenediamine at the surface of as-synthesized red CDs (r-CDs) efficiently binds Cu(2+) ions to produce a strong visible absorption that overlaps the emission of blue CDs (b-CDs); on the other hand, the Cu(2+) ions render the adsorption of small b-CDs onto the surface of larger r-CDs through their dual-coordinating interactions with the surface ligands of both r-CDs and b-CDs...
May 26, 2017: ACS Applied Materials & Interfaces
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