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https://www.readbyqxmd.com/read/29908420/ticagrelor-versus-clopidogrel-after-fibrinolytic-therapy-in-patients-with-st-elevation-myocardial-infarction-rationale-and-design-of-the-ticagrelor-in-patients-with-st-elevation-myocardial-infarction-treated-with-thrombolysis-treat-trial
#1
Otavio Berwanger, Jose C Nicolau, Antonio C Carvalho, Lixin Jiang, Shaun Goodman, Stephen J Nicholls, Alexander Parkhomenko, Oleg Averkov, Carlos Tajer, Germán Malaga, Jose F Kerr Saraiva, Francisco Fonseca, Helio P Guimaraes, Pedro G M de Barros E Silva, Lucas P Damiani, Denise M Paisani, Camila M R Lasagno, Carolina T Candido, Nanci Valeis, Diogo D F Moia, Leopoldo S Piegas, Christopher B Granger, Harvey White, Renato D Lopes
BACKGROUND: The safety and efficacy of ticagrelor in patients with ST-elevation myocardial infarction (STEMI) treated with fibrinolytic therapy remain uncertain. OBJECTIVES: The primary objective of the TicagRElor in pAtients with ST elevation myocardial infarction treated with Thrombolysis (TREAT) trial is to evaluate the short-term safety of ticagrelor when compared with clopidogrel in STEMI patients treated with fibrinolytic therapy. Key secondary objectives are to assess the safety and efficacy of ticagrelor compared with clopidogrel at 12-months...
March 3, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29906667/the-high-cost-of-critical-care-unit-over-utilization-for-patients-with-nste-acs
#2
Sean van Diepen, Dat T Tran, Justin A Ezekowitz, David A Zygun, Jason N Katz, Renato D Lopes, L Kristin Newby, Finlay A McAlister, Padma Kaul
BACKGROUND: There is substantial variability among hospitals in critical care unit (CCU) utilization for patients admitted with non-ST-Segment Elevation Acute Coronary Syndromes (NSTE ACS). We estimated the potential cost saving if all hospitals adopted low CCU utilization practices for patients with NSTE ACS. METHODS: National hospital claims data were used to identify all patients with a primary diagnosis of NSTE ACS initially admitted to an acute care hospital between 2007 and 2013...
May 19, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29904459/unusual-presentation-of-spontaneous-coronary-artery-dissection-in-an-older-male
#3
Rajveer Joea, Sarah J Strube, Todd K Zynda
Spontaneous coronary artery dissection (SCAD) is a variant of acute coronary syndrome (ACS) that is poorly understood. SCAD has been linked to fibromuscular dysplasia (FMD), connective tissue disease (CTD), pregnancy and hormonal imbalance, systemic inflammatory conditions (e.g. IBD, vasculitis), and coronary artery vasospasm rather than traditional cardiac risk factors. Symptomology generally accompanying SCAD is indistinguishable from ACS making the timely recognition and diagnosis vital for prompt treatment...
June 2018: Cardiology Research
https://www.readbyqxmd.com/read/29904441/ischemic-modified-albumin-predicts-critical-coronary-artery-disease-in-unstable-angina-pectoris-and-non-st-elevation-myocardial-infarction
#4
Abdullah Orhan Demirtas, Turgut Karabag, Derya Demirtas
Background: In this study, whether ischemia modified albumin (IMA) has a role in showing severity or criticality of coronary arteries in patients with unstable angina pectoris (USAP)/non-ST-elevation myocardial infarction (NSTEMI) was assessed. Methods: A total of 65 patients (40 male (M) and 25 female (F) patients; mean age 59.7 ± 12.1 years) with the initial diagnosis of USAP/NSTEMI were included in this study. The levels of IMA, troponin T, creatine kinase MB (CK-MB), C-reactive protein (CRP), brain natriuretic peptide (BNP), creatinine, lipid panel, and whole blood count were measured from venous blood obtained from each patient within 3 h after the onset of symptoms...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29901444/establishment-of-healing-profile-and-neointimal-transformation-in-the-new-polymer-free-biolimus-a9-coated-coronary-stent-by-longitudinal-sequential-optical-coherence-tomography-assessments-the-ego-biofreedom-study
#5
Stephen Wai Luen Lee, Frankie C C Tam, Kelvin K W Chan, Simon C C Lam, Shun-Ling Kong, Catherine P Shea, Michael K L Wong, Anthony Y T Wong, Arthur S Y Yung, Li-Wei Zhang, Yui-Ming Lam, Gary S Mintz, Ricardo A Costa, Hans-Peter Stoll, Akiko Maehara
AIMS: In patients at high bleeding risk treated with 1 month of dual antiplatelet therapy, the polymer-free, biolimus A9-coated BioFreedom stent (BFS) was found safer and more efficacious than bare metal stents. We used sequential optical coherence tomography (OCT) to assess the time course of strut coverage and neointimal transformation from 1 to 9 months. METHODS AND RESULTS: We randomly assigned 104 BFS recipients to 1 of 5 groups with angiography and OCT follow-up at 1, 2, 3, 4, or 5 months, together with another follow-up for all at 9 months...
June 12, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29896993/prolonged-veno-arterial-extracorporeal-life-support-for-cardiac-failure
#6
Sabina Pw Guenther, Yasuhiro Shudo, William Hiesinger, Dipanjan Banerjee
OBJECTIVES: In intractable cardiogenic shock, extracorporeal life support frequently is the last treatment option. Outcomes of prolonged veno-arterial extracorporeal life support for cardiac failure are poorly defined. METHODS: We retrospectively analyzed 10 patients (4 females, age = 36 ± 16 years) who underwent prolonged extracorporeal life support (≥7 days) from December 2015 to March 2017 for cardiogenic shock. The primary endpoint was survival to hospital discharge...
June 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29895599/activated-clotting-time-to-guide-heparin-dosing-in-non-st-segment-elevation-acute-coronary-syndrome-patients-undergoing-percutaneous-coronary-intervention-and-treated-with-iib-iiia-inhibitors-impact-on-ischemic-and-bleeding-outcomes-insights-from-the-tao-trial
#7
Jean-Guillaume Dillinger, Gregory Ducrocq, Yedid Elbez, Marc Cohen, Christoph Bode, Charles Pollack, José C Nicolau, Patrick Henry, Sasko Kedev, Stephen D Wiviott, Marc S Sabatine, Shamir R Mehta, Philippe Gabriel Steg
BACKGROUND: Monitoring anticoagulation with activated clotting time (ACT) has been proposed to reduce ischemic or bleeding events. However, the value of using ACT to improve outcomes is uncertain. This study sought to determine the relationship between ACT and outcomes during percutaneous coronary intervention in patients with non-ST-segment-elevation acute coronary syndrome (NSTE-ACS) treated by unfractionated heparin with GPIs (glycoprotein IIb/IIIa inhibitors). METHODS AND RESULTS: From the randomized TAO trial (Treatment of Acute Coronary Syndromes With Otamixaban), we analyzed the value of ACT to predict ischemic and bleeding outcomes in the 3275 patients receiving unfractionated heparin plus eptifibatide...
June 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29893692/management-of-older-patients-presenting-with-non-st-elevation-acute-coronary-syndrome
#8
Danny Chan, Lucy Lawson, Vijay Kunadian
No abstract text is available yet for this article.
June 8, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29893357/one-year-outcomes-in-patients-with-st-segment-elevation-myocardial-infarction-caused-by-unprotected-left-main-coronary-artery-occlusion-treated-by-primary-percutaneous-coronary-intervention
#9
Hai-Wei Liu, Ya-Ling Han, Quan-Min Jin, Xiao-Zeng Wang, Ying-Yan Ma, Geng Wang, Bin Wang, Kai Xu, Yi Li, Shao-Liang Chen
Background: Very few data have been reported for ST-segment elevation myocardial infarction (STEMI) caused by unprotected left main coronary artery (ULMCA) occlusion, and very little is known about the results of this subgroup of patients who underwent primary percutaneous coronary intervention (PCI). The aim of this study was to determine the clinical features and outcomes of patients with STEMI who underwent primary PCI for acute ULMCA occlusion. Methods: From January 2000 to February 2014, 372 patients with STEMI caused by ULMCA acute occlusion (ULMCA-STEMI) who underwent primary PCI at one of two centers were enrolled...
June 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29891037/clinical-characteristics-and-outcomes-in-young-patients-with-st-segment-elevation-myocardial-infarction-after-primary-percutaneous-coronary-intervention
#10
Ming Gao, Waiou Zhao, Zhiguo Zhang, Ling Qin, Weihua Zhang, Yang Zheng
BACKGROUND: There are few published studies of ST-segment elevation myocardial infarction (STEMI) in younger individuals. The differences between these "younger" and "older" individuals may not be fully appreciated by clinicians. The aim of this study was to determine the reasons for the earlier presentation and help to identify strategies for prevention of recurrent myocardial infarction (MI) in younger patients. METHODS: The study population was a cohort of 2,419 consecutive STEMI patients who were treated with primary percutaneous coronary intervention...
June 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29888611/trimetazidine-in-the-prevention-of-tissue-ischemic-conditions
#11
Manolis S Kallistratos, Leonidas E Poulimenos, Sofia Giannitsi, Pavlos Tsinivizov, Athanasios J Manolis
Trimetazidine (TMZ) is a metabolic agent with significant anti-ischemic properties. By inhibiting the terminal enzyme in the β-oxidation pathway, it shifts the energy substrate metabolism, enhancing glucose metabolism. Thus, it maintains the required energy production with less oxygen consumption, an effect necessary in cases of myocardi. Trimetazidine was recently reaccredited as add-on therapy for symptomatic treatment in patients with stable angina, not adequately controlled or intolerant to first-line therapy...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29887577/cami-nstemi-score-china-acute-myocardial-infarction-registry-derived-novel-tool-to-predict-in-hospital-death-in-non-st-segment-elevation-myocardial-infarction-patients
#12
Rui Fu, Chenxi Song, Jingang Yang, Yan Wang, Bao Li, Haiyan Xu, Xiaojin Gao, Wei Li, Jia Liu, Kefei Dou, Yuejin Yang
BACKGROUND: Accurate risk stratification of non-ST segment elevation myocardial infarction (NSTEMI) patients is important due to great variability in mortality risk, but, to date, no prediction model has been available. The aim of this study was therefore to establish a risk score to predict in-hospital mortality risk in NSTEMI patients.Methods and Results:We enrolled 5,775 patients diagnosed with NSTEMI from the China Acute Myocardial Infarction (CAMI) registry and extracted relevant data...
June 8, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29885827/prognostic-value-of-myocardial-deformation-imaging-by-cardiac-magnetic-resonance-feature-tracking-in-patients-with-a-first-st-segment-elevation-myocardial-infarction
#13
Gaetano Nucifora, Daniele Muser, Chiara Tioni, Ranjit Shah, Joseph B Selvanayagam
AIM: Scarce data are available whether cardiac magnetic resonance (CMR) assessment of myocardial deformation provides independent and incremental prognostic information in patients with ST-segment elevation myocardial infarction (STEMI). The aim of the present study was to investigate the prognostic utility of CMR feature-tracking derived left ventricular (LV) global circumferential strain (GCS) in STEMI patients. METHODS: A total of 180 patients (mean age 60 ± 12 years, 72% male) admitted because of a first STEMI were included...
May 26, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29885694/impact-of-chronic-total-occlusion-in-a-non-infarct-related-coronary-artery-on-myocardial-injury-assessed-by-cardiac-magnetic-resonance-imaging-and-prognosis-in-st-elevation-myocardial-infarction
#14
Mohammed Saad, Thomas Stiermaier, Georg Fuernau, Janine Pöss, Steffen Desch, Holger Thiele, Ingo Eitel
BACKGROUND: Mechanisms underlying increased mortality in patients with chronic total occlusion (CTO) of a non-infarct-related artery (non-IRA) are unknown. Cardiac magnetic resonance (CMR) is uniquely suited to provide important mechanistic and pathophysiological information on myocardial damage and reperfusion injury. Aim of this study was to investigate the association of a CTO in a non-IRA with myocardial damage assessed by CMR in patients with ST-elevation myocardial infarction (STEMI)...
August 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29882071/left-ventricular-myocardial-deformation-in-takotsubo-syndrome-a-cardiovascular-magnetic-resonance-myocardial-feature-tracking-study
#15
Thomas Stiermaier, Torben Lange, Amedeo Chiribiri, Christian Möller, Tobias Graf, Christina Villnow, Uwe Raaz, Adriana Villa, Johannes T Kowallick, Joachim Lotz, Gerd Hasenfuß, Holger Thiele, Andreas Schuster, Ingo Eitel
OBJECTIVES: This study assessed the applicability and prognostic value of cardiovascular magnetic resonance (CMR) left ventricular deformation analysis in Takotsubo syndrome (TTS). METHODS: CMR-feature tracking was performed blinded in a core laboratory to determine circumferential (CS), radial (RS) and longitudinal strain (LS) in 141 TTS patients participating in this cohort study. A subgroup of consecutive TTS patients (n = 20) was compared with age- and sex-matched controls with anterior ST-segment elevation myocardial infarction (STEMI) and non-STEMI as well as healthy subjects...
June 7, 2018: European Radiology
https://www.readbyqxmd.com/read/29881284/anemia-and-acute-coronary-syndrome-current-perspectives
#16
REVIEW
Miriam Stucchi, Silvia Cantoni, Enrico Piccinelli, Stefano Savonitto, Nuccia Morici
Reference hemoglobin (Hb) values for the definition of anemia are still largely based on the 1968 WHO Scientific Group report, which established a cutoff value of <13 g/dL for adult men and <12 g/dL for adult nonpregnant women. Subsequent studies identified different normal values according to race and age. Estimated prevalence of anemia on admission in the setting of an acute coronary syndrome (ACS) is between 10% and 43% of the patients depending upon the specific population under investigation. Furthermore, up to 57% of ACS patients may develop hospital-acquired anemia (HAA)...
2018: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29877884/sex-differences-in-acute-myocardial-infarction-hospital-management-and-outcomes-update-from-facilities-with-comparable-standards-of-quality-care
#17
Tomás Romero, Kristina L Greenwood, Dale Glaser
BACKGROUND: Acute myocardial infarction (AMI) sex disparities in management and outcomes have long been attributed to multiple factors, although questions regarding their relevance have not been fully addressed. OBJECTIVE: The aim of this study was to identify current factors associated with sex-related AMI management and outcomes disparities in hospitals with comparable quality care standards. METHODS: This is a cross-sectional study of 299 women and 540 men with AMI discharged in 2013 from 3 southern California hospitals with tertiary cardiac care...
June 6, 2018: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29875961/-acute-coronary-syndrome-with-st-segment-elevation-revealing-acute-myocarditis-in-a-young-patient-with-normal-coronaries
#18
Houssam Laachach, Bachrif Mohamed, Ilham Benahmed, Alaa Fliti, Noha El Ouafi
Acute coronary syndromes may occur in young adults and have a non-atheromatous origin. We report the case of a young man admitted with acute coronary artery disease with systematic ST-segment elevation. Coronarography showed no abnormality and MRI confirmed acute myocarditis. Outcome was favorable under medical treatment.
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29871939/temporal-trends-in-identification-management-and-clinical-outcomes-after-out-of-hospital-cardiac-arrest-insights-from-the-myocardial-ischaemia-national-audit-project-database
#19
Tiffany Patterson, Gavin D Perkins, Yahma Hassan, Konstantinos Moschonas, Huon Gray, Nick Curzen, Mark de Belder, Jerry P Nolan, Peter Ludman, Simon R Redwood
BACKGROUND: There is wide variation in survival rates from out-of-hospital cardiac arrest (OHCA) and overall survival remains poor. There is an expert consensus that early reperfusion therapy in ST-elevation reduces mortality. The management of patients without ST-elevation, however, is controversial. METHODS AND RESULTS: The Myocardial Ischaemia National Audit Project database is a national registry of all hospital admissions in England and Wales treated as an acute coronary syndrome (ACS)...
June 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29862825/prognostic-values-of-fasting-hyperglycaemia-in-non-diabetic-patients-with-acute-coronary-syndrome-a-prospective-cohort-study
#20
Baris Gencer, Fabio Rigamonti, David Nanchen, Roland Klingenberg, Lorenz Räber, Elisavet Moutzouri, Reto Auer, David Carballo, Dik Heg, Stephan Windecker, Thomas Felix Lüscher, Christian M Matter, Nicolas Rodondi, François Mach, Marco Roffi
BACKGROUND: Controversy remains regarding the prevalence of hyperglycaemia in non-diabetic patients hospitalised with acute coronary syndrome and its prognostic value for long-term outcomes. METHODS AND RESULTS: We evaluated the prevalence of hyperglycaemia (defined as fasting glycaemia ⩾10 mmol/l) among patients with no known diabetes at the time of enrolment in the prospective Special Program University Medicine-Acute Coronary Syndromes cohort, as well as its impact on all-cause death, myocardial infarction, stroke and incidence of diabetes at one year...
June 1, 2018: European Heart Journal. Acute Cardiovascular Care
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