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https://www.readbyqxmd.com/read/29447789/comprehensive-electrocardiogram-to-device-time-for-primary-percutaneous-coronary-intervention-in-st-segment-elevation-myocardial-infarction-a-report-from-the-american-heart-association-mission-lifeline-program
#1
Jay S Shavadia, William French, Anne S Hellkamp, Laine Thomas, Eric R Bates, Steven V Manoukian, Michael C Kontos, Robert Suter, Timothy D Henry, Harold L Dauerman, Matthew T Roe
BACKGROUND: Assessing hospital-related network-level primary percutaneous coronary intervention (PCI) performance for ST-segment elevation myocardial infarction (STEMI) is challenging due to differential time-to-treatment metrics based on location of diagnostic electrocardiogram (ECG) for STEMI. METHODS: STEMI patients undergoing primary PCI at 588 PCI-capable hospitals in AHA Mission: Lifeline (2008-2013) were categorized by initial STEMI identification location: PCI-capable hospitals (Group 1); pre-hospital setting (Group 2); and non-PCI-capable hospitals (Group 3)...
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29447786/high-sensitivity-cardiac-troponin-t-left-ventricular-function-and-outcome-in-non-st-elevation-acute-coronary-syndrome
#2
K M Eggers, T Jernberg, B Lindahl
BACKGROUND: Cardiac troponin (cTn) levels reflect infarct size and depressed left ventricular ejection fraction (LVEF) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). However, there is very limited information on whether cTn measured with a high-sensitivity (hs) assay would provide incremental prognostic information to the LVEF in NSTE-ACS patients. METHODS: This was a registry-based study (SWEDEHEART registry) investigating 20,652 NSTE-ACS patients with available information on hs-cTnT (highest level recorded during the hospitalization) and the LVEF estimated using echocardiography...
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29446567/prognostic-value-of-the-index-of-microcirculatory-resistance-after-percutaneous-coronary-intervention-in-patients-with-non-st-segment-elevation-acute-coronary-syndrome
#3
Tadashi Murai, Taishi Yonetsu, Yoshihisa Kanaji, Eisuke Usui, Masahiro Hoshino, Masahiro Hada, Rikuta Hamaya, Yoshinori Kanno, Tetsumin Lee, Tsunekazu Kakuta
BACKGROUND: The prognostic value of physiological indices in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients undergoing percutaneous coronary intervention (PCI) is unknown. We investigated the prognostic efficacy of physiological indices obtained after PCI in patients with NSTE-ACS. METHODS: Eighty-three patients (men: n = 70, age: 63.7 ± 9.7 years) undergoing PCI for NSTE-ACS within 48 hr postadmission were investigated. Fractional flow reserve (FFR), coronary flow reserve (CFR), and the index of microcirculatory resistance (IMR) of the culprit vessels were measured after the completion of PCI...
February 15, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29443445/aspirin-withdrawal-in-patients-treated-with-ticagrelor-presenting-with-non-st-elevation-myocardial-infarction
#4
Roy Beigel, Israel Mazin, Edward Koifman, Michael Shechter, Hanna Pres, Nir Shlomo, Nurit Rosenberg, Elad Asher, Shlomi Matetzky
BACKGROUND: Recent studies have shown that the thromboxaneA 2 -dependent pathway is dependent upon the adenosine diphosphate (ADP)-P2Y 12 pathway and that strong P2Y 12 receptor blockade alone causes inhibition of platelet aggregation that is minimally enhanced by aspirin. Data from the PLATO trial suggested that among ticagrelor-treated patients, high compared with low dose (<100mg\day) aspirin is associated with increased risk for ischemic events. OBJECTIVES: In the current prospective, randomized, placebo-controlled, double-blind, cross-over study, we sought to evaluate the impact of aspirin withdrawal on platelet reactivity in acute coronary syndrome (ACS) patients treated with a potent P2Y 12 blocker...
February 14, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29439831/routine-invasive-versus-selective-invasive-strategy-in-elderly-patients-older-than-75-years-with-non-st-segment-elevation-acute-coronary-syndrome-a-systematic-review-and-meta-analysis
#5
Aakash Garg, Lohit Garg, Manyoo Agarwal, Amit Rout, Hitesh Raheja, Sahil Agrawal, Sunil V Rao, Marc Cohen
OBJECTIVE: To evaluate outcomes of routine invasive strategy (RIS) compared with selective invasive strategy (SIS) in elderly patients older than 75 years with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). METHODS: We systematically searched databases for randomized controlled trials (RCTs) between January 1, 1990, and October 1, 2016, comparing RIS with SIS for elderly patients (age>75 years) with NSTE-ACS. Random effects meta-analysis was conducted to estimate odds ratio (OR) with 95% CIs for composite of death or myocardial infarction (MI), and individual end points of all-cause death, cardiovascular (CV) death, MI, revascularization, and major bleeding...
February 10, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29438470/use-of-clinical-risk-stratification-in-non-st-elevation-acute-coronary-syndromes-an-analysis-from-the-concordance-registry
#6
Rong Bing, Shaun G Goodman, Andrew T Yan, Keith Fox, Chris P Gale, Karice Hyun, Mario D'Souza, Pratap Shetty, John Atherton, Chris Hammett, Derek Chew, David Brieger
No abstract text is available yet for this article.
February 9, 2018: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29435859/bridging-the-atlantic-gap-in-clinical-guidelines-for-non-st-elevation-acute-coronary-syndromes
#7
EDITORIAL
Francesco Nudi, Alessandro Nudi, Giuseppe Biondi-Zoccai, Orazio Schillaci
No abstract text is available yet for this article.
February 12, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29434090/determinants-and-long-term-outcomes-of-percutaneous-coronary-interventions-vs-surgery-for-multivessel-disease-according-to-clinical-presentation
#8
Sung-Jin Hong, Byeong-Keuk Kim, Sanghoon Shin, Yongsung Suh, Seunghwan Kim, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
BACKGROUND: The long-term outcome of percutaneous coronary intervention (PCI) vs. coronary artery bypass graft (CABG), particularly for patients with non-ST-elevation acute coronary syndrome (NSTE-ACS), remains controversial.Methods and Results:We retrospectively analyzed 2,827 patients (stable coronary artery disease [SCAD], n=1,601; NSTE-ACS, n=1,226) who underwent either PCI (n=1,732) or CABG (n=1,095). The 8-year composite of cardiac death and myocardial infarction (MI) was compared between PCI and CABG before and after propensity matching...
February 9, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29432377/two-year-follow-up-of-patients-with-unstable-angina-non-st-segment-elevation-myocardial-infarction-undergoing-early-invasive-strategy-predictors-of-normal-or-near-normal-coronary-angiography-and-mortality
#9
Yaser Jenab, Ebrahim Kassaian, Hamid Reza Pourhosseini, Mojtaba Salarifar, Arash Jalali, Azita Hajhossein Talasaz
BACKGROUND: Predictors of normal or near-normal coronary angiography (NONCAG) in patients with unstable angina/non-ST-elevation myocardial infarction (UA/NSTEMI) and their importance regarding the prognosis are not understood. Accordingly, we determined these predictors as well as mortality risk factors at 2-year follow-up of UA/NSTEMI patients managed by the early invasive strategy. METHODS: We prospectively studied consecutive patients with UA/NSTEMI managed with the early invasive strategy at Tehran Heart Center, in 1-year period...
March 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29432373/contrast-induced-nephropathy-in-stemi-patients-with-and-without-chronic-kidney-disease
#10
Tarun Jain, Sunay Shah, Jainil Shah, Gordon Jacobsen, Akshay Khandelwal
INTRODUCTION: Contrast-induced nephropathy (CIN) following percutaneous coronary intervention (PCI) is associated with adverse outcomes; however, there are scarce data comparing clinical outcomes of post-PCI CIN in ST elevation myocardial infarction (STEMI) patients with and without chronic kidney disease (CKD). We sought to assess the incidence, clinical predictors, and short-term and long-term clinical outcomes of post-PCI CIN in STEMI patients with and without CKD. METHODS: We performed a retrospective observational cohort study involving 554 patients who underwent PCI for STEMI from February 2010 to November 2013...
March 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29432372/ecg-to-decision-time-impact-on-30-day-mortality-and-reperfusion-times-for-stemi-care
#11
Richard Mullvain, Daniel M Saman, Ashlee Rostvedt, Pauline Landgren
OBJECTIVES: Little data are published on the unique care performance metric of electrocardiogram-to-decision time (E2Decide) for primary percutaneous coronary intervention (PCI) treatment of ST-elevation myocardial infarction (STEMI). The objective of this study is to evaluate E2Decide time on mortality and delayed reperfusion. METHODS: This was a retrospective study of STEMI activations treated with primary PCI at 2 PCI-capable hospitals located in Duluth, Minnesota, and Fargo, North Dakota, originating in 3 different settings: (1) primary PCI-capable hospital emergency departments, (2) non-PCI facilities, and (3) in the field by emergency medical services...
March 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29432371/clinical-outcomes-of-transferred-versus-onsite-primary-percutaneous-coronary-intervention-for-patients-with-stemi-time-to-look-beyond-door-to-balloon-time
#12
Jaya Mallidi, Paul Visintainer, Indupriya Pallekonda, Daniel Fisher, Kurt Barringhaus, Aaron Kugelmass, Amir Lotfi
BACKGROUND: It is currently unknown if the delay due to practical aspects associated with transfer of patients from a non-percutaneous coronary intervention (PCI) facility to a primary PCI facility is associated with adverse outcomes. METHODS: We conducted a retrospective cohort study of all patients who presented with ST-segment elevation myocardial infarction (STEMI) and underwent primary PCI in 2 large regional STEMI centers in Massachusetts between January 2005 and June 2009...
March 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29432131/t-wave-abnormality-as-electrocardiographic-signature-of-myocardial-edema-in-non-st-elevation-acute-coronary-syndromes
#13
Andrea Cardona, Karolina M Zareba, Haikady N Nagaraja, Stephen F Schaal, Orlando P Simonetti, Giuseppe Ambrosio, Subha V Raman
BACKGROUND: T-wave abnormalities are common during the acute phase of non-ST-segment elevation acute coronary syndromes, but mechanisms underlying their occurrence are unclear. We hypothesized that T-wave abnormalities in the presentation of non-ST-segment elevation acute coronary syndromes correspond to the presence of myocardial edema. METHODS AND RESULTS: Secondary analysis of a previously enrolled prospective cohort of patients presenting with non-ST-segment elevation acute coronary syndromes was conducted...
January 26, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29429635/clinical-findings-after-bioresorbable-vascular-scaffold-implantation-in-an-unrestricted-cohort-of-patients-with-st-segment-elevation-myocardial-infarction-from-the-rai-registry
#14
Elisabetta Moscarella, Alfonso Ielasi, Attilio Varricchio, Maria Carmen De Angelis, Bruno Loi, Giuseppe Tarantini, Paolo Calabrò, Bernardo Cortese, Pietro Mazzarotto, Gabriele Gabrielli, Francesco Pisano, Michela Facchin, Leonardo Misuraca, Valerio Lucci, Roberto Gistri, Gabriele Tumminello, Luciano Moretti, Alessandro Colombo, Alessandro Durante, Massimo Fineschi, Davide Piraino, Maurizio Ferrario, Sebastian Coscarelli, Annamaria Nicolino, Maurizio Tespili, Donatella Corrado, Giuseppe Steffenino
BACKGROUND: The bioresorbable vascular scaffold (BVS) technology may be an appealing option in ST-segment elevation myocardial infarction (STEMI) patients. However, the available evidence on its use in this challenging subset is limited. METHODS: Registro Absorb Italiano (RAI) is a multicenter, prospective registry that aims to assess BVS performance through a 5-year follow-up of all consecutive patients who undergone at least 1 successful BVS implantation. As a part of it, a subgroup analysis in STEMI patients was performed and the outcomes of this cohort compared to the remaining population (defined as "non-STEMI") are reported here...
February 3, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29425559/percutaneous-coronary-interventions-for-non-st-elevation-acute-coronary-syndromes-the-two-faces-of-inappropriateness
#15
EDITORIAL
Raffaele De Caterina, Mario Marzilli
No abstract text is available yet for this article.
March 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29425553/invasive-treatment-of-nstemi-patients-in-german-chest-pain-units-evidence-for-a-treatment-paradox
#16
Frank P Schmidt, Claus Schmitt, Matthias Hochadel, Evangelos Giannitsis, Harald Darius, Lars S Maier, Claus Schmitt, Gerd Heusch, Thomas Voigtländer, Harald Mudra, Tommaso Gori, Jochen Senges, Thomas Münzel
BACKGROUND: Patients with non ST-segment elevation myocardial infarction (NSTEMI) represent the largest fraction of patients with acute coronary syndrome in German Chest Pain units. Recent evidence on early vs. selective percutaneous coronary intervention (PCI) is ambiguous with respect to effects on mortality, myocardial infarction (MI) and recurrent angina. With the present study we sought to investigate the prognostic impact of PCI and its timing in German Chest Pain Unit (CPU) NSTEMI patients...
March 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29424484/acute-heart-failure-following-myocardial-infarction-complement-activation-correlates-with-the-severity-of-heart-failure-in-patients-developing-cardiogenic-shock
#17
Hilde L Orrem, Per H Nilsson, Søren E Pischke, Guro Grindheim, Peter Garred, Ingebjørg Seljeflot, Trygve Husebye, Pål Aukrust, Arne Yndestad, Geir Ø Andersen, Andreas Barratt-Due, Tom E Mollnes
AIMS: Heart failure (HF) is an impending complication to myocardial infarction. We hypothesized that the degree of complement activation reflects severity of HF following acute myocardial infarction. METHODS AND RESULTS: The LEAF trial (LEvosimendan in Acute heart Failure following myocardial infarction) evaluating 61 patients developing HF within 48 h after percutaneous coronary intervention-treated ST-elevation myocardial infarction herein underwent a post hoc analysis...
February 9, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29422071/prevalence-and-outcome-of-patients-with-non-st-segment-elevation-myocardial-infarction-with-occluded-culprit-artery-a-systemic-review-and-meta-analysis
#18
Chi-Sheng Hung, Ying-Hsien Chen, Ching-Chang Huang, Mao-Shin Lin, Chih-Fan Yeh, Hung-Yuan Li, Hsien-Li Kao
BACKGROUND: The aim was to determine the prevalence and impact of an occluded "culprit" artery (OCA) in patients with non-ST segment elevation myocardial infarction (NSTEMI). METHODS: We searched PubMed, EMBASE, and Web of Science, with no language restrictions, up to 1 Jul. 2016. Observational cohorts or clinical trials of adult NSTEMI were eligible for inclusion to determine the prevalence if the proportion of OCA on coronary angiography was reported...
February 9, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29421988/high-density-lipoprotein-cholesterol-hdl-c-levels-independently-correlates-with-cardiac-arrhythmias-and-atrial-fibrillation
#19
Farzin Brian Boudi, Nicholas Kalayeh, Mohammad Reza Movahed
OBJECTIVE: Acute coronary syndrome is frequently complicated by rhythm disturbances, yet any association between high-density lipoprotein (HDL) cholesterol levels and arrhythmias in the setting of non-ST-segment elevation myocardial infarction (non-STEMI) is uncertain. The goal of this study was to evaluate any association between HDL-cholesterol levels and arrhythmias in the setting of non-STEMI. METHODS: Retrospective data from Phoenix Veterans Affair Medical Center records were utilized for our study...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29421016/rationale-and-design-of-the-dear-old-trial-randomized-evaluation-of-routinely-deferred-versus-early-invasive-strategy-in-elderly-patients-of-75-years-or-older-with-non-st-elevation-myocardial-infarction
#20
Wen-Xiu Leng, Jingang Yang, Wei Li, Yang Wang, Yue-Jin Yang
BACKGROUND: Comparing with conservative strategy, early invasive approach has been shown to be beneficial for initially stabilized patients with non-ST-elevation myocardial infarction (NSTEMI). However, concerns of increased risk of bleeding and other complications associated with early revascularization in patients aged ≥75 years persist. A routinely deferred invasive strategy aiming to facilitate revascularization after stabilizing the culprit lesion predominates across China. AIM: The aim was to compare efficacy and safety of deferred invasive strategy versus guideline-recommended early invasive strategy in initially stabilized Chinese patients aged ≥75 years with NSTEMI...
February 2018: American Heart Journal
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