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https://www.readbyqxmd.com/read/28419993/reduction-in-peripheral-cd19-cd24hcd27-b-cell-frequency-predicts-favourable-clinical-course-in-xelox-treated-patients-with-advanced-gastric-cancer
#1
Wei Li, Dongli Song, Hong Li, Li Liang, Naiqing Zhao, Tianshu Liu
BACKGROUND: Accumulating evidence suggests that regulatory B cells (Bregs) play an important role in modulating the immune response to tumours. Our previous study indicated that a small percentage of peripheral CD19+CD24hCD27+ Breg cells slowed gastric cancer progression in XELOX-treated patients. Here, we further investigated the relationship between dynamic changes in circulating Breg cells and the clinical course in XELOX-treated gastric cancer patients. METHODS: A total of 52 patients with advanced gastric cancer were enrolled in this study...
April 14, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28391355/comparison-between-hypersensitivity-reactions-to-cycles-of-modified-folfox6-and-xelox-therapies-in-patients-with-colorectal-cancer
#2
Hideki Ohta, Takahiro Hayashi, Sumie Murai, Hideyo Shiouchi, Yosuke Ando, Satomi Kumazawa, Kaori Ito, Yoshiaki Ikeda, Hiroshi Matsuoka, Kotaro Maeda, Kenji Kawada, Kimio Yasuda, Shigeki Yamada
PURPOSE: Although hypersensitivity reactions (HSRs) to oxaliplatin (L-OHP) therapy are well-documented, few reports have compared different therapies in terms of HSR occurrence. In this study, we compared the frequency and pattern of HSRs to modified FOLFOX6 (mFOLFOX6; 5-fluorouracil, levofolinate calcium and L-OHP infusions) and XELOX (capecitabine and L-OHP) therapies, and sought to identify risk factors associated with HSRs. METHODS: Patients who had received mFOLFOX6 or XELOX chemotherapeutic regimens for unresectable colon or rectal cancer or as adjuvant chemotherapy following colon cancer surgery between April 2012 and August 2015 were included...
April 8, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28327986/phase-iii-trial-comparing-3-6-months-of-adjuvant-folfox4-xelox-in-stage-ii-iii-colon-cancer-safety-and-compliance-in-the-tosca-trial
#3
S Lonardi, A Sobrero, G Rosati, M Di Bartolomeo, M Ronzoni, G Aprile, B Massida, M Scartozzi, M Banzi, M G Zampino, F Pasini, P Marchetti, M Cantore, A Zaniboni, L Rimassa, L Ciuffreda, D Ferrari, S Barni, V Zagonel, E Maiello, E Rulli, R Labianca
No abstract text is available yet for this article.
February 23, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28279170/patients-with-pathological-stage-n2-rectal-cancer-treated-with-early-adjuvant-chemotherapy-have-a-lower-treatment-failure-rate
#4
Yan-Ru Feng, Jing Jin, Hua Ren, Xin Wang, Shu-Lian Wang, Wei-Hu Wang, Yong-Wen Song, Yue-Ping Liu, Yuan Tang, Ning Li, Xin-Fan Liu, Hui Fang, Zi-Hao Yu, Ye-Xiong Li
BACKGROUND: In this era of oxaliplatin-based adjuvant therapy, the optimal sequence in which chemoradiotherapy should be administered for pathological stage N2 rectal cancer is unknown. The aim of this study was to investigate this sequence. METHODS: In the primary adjuvant concurrent chemoradiotherapy (A-CRT) group (n = 71), postoperative concurrent chemoradiotherapy was administered before adjuvant chemotherapy. In the primary adjuvant chemotherapy (A-CT) group (n = 43), postoperative concurrent chemoradiotherapy was administered during or after adjuvant chemotherapy...
March 9, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28174488/a-pilot-phase-ii-study-of-neoadjuvant-triplet-chemotherapy-regimen-in-patients-with-locally-advanced-resectable-colon-cancer
#5
Haitao Zhou, Yan Song, Jun Jiang, Haitao Niu, Hong Zhao, Jianwei Liang, Hao Su, Zheng Wang, Zhixiang Zhou, Jing Huang
OBJECTIVE: This study aims to investigate the feasibility, safety and efficacy of triplet regimen of neoadjuvant chemotherapy in patients with locally advanced resectable colon cancer. METHODS: Patients with clinical stage IIIb colon cancer received a perioperative triple chemotherapy regimen (oxaliplatin 85 mg/m(2) and irinotecan 150 mg/m(2), combined with folinic acid 200 mg, 5-fluorouracil 500 mg bolus and then 2,400 mg/m(2) by 44 h infusion or capecitabine 1 g/m(2) or S-1 40-60 mg b...
December 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28133349/-long-term-survival-of-a-patient-with-sigmoid-colon-cancer-with-multiple-visceral-metastases
#6
Yoshiyuki Sasaki, Naoto Nishigori, Fumikazu Koyama, Takeshi Ueda, Takashi Inoue, Keijirou Kawasaki, Shinsaku Obara, Takayuki Nakamoto, Yasuyuki Nakamura, Hisao Fujii, Yoshiyuki Nakajima
A 66-year-old woman underwent total pelvic exenteration for a pelvic tumor. The pathological diagnosis was sigmoid colon cancer T4b(in the small intestine, uterus, and vagina), N0, M0, Stage II . The patient was treated with XELOX for 6 months as adjuvant chemotherapy and was then treated with IRIS for another 6 months. Brain metastasis developed in the left occipital lobe after 12 months, and she underwent craniotomy and enucleation of the tumor. Liver metastasis and peritoneal dissemination metastasis developed 16 months after her initial diagnosis...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133314/-a-case-of-metastatic-lung-cancer-from-colon-cancer-with-a-long-partial-response-with-regorafenib-treatment
#7
Yasuhito Iseki, Masakazu Yashiro, Masatsune Shibutani, Hisashi Nagahara, Kiyoshi Maeda, Shinji Matsutani, Tatsuro Tamura, Go Ohira, Sadaaki Yamazoe, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Hiroaki Tanaka, Kazuya Muguruma, Kosei Hirakawa, Masaichi Ohira
A 66-year-old woman underwent sigmoidectomy for colon cancer. The final diagnosis was early cancer of pT2 pN0 and M0 (fStage I ). A chest CT revealed lung metastasis and lymph node metastasis 6 years after surgery. The patient was treated sequentially with FOLFOX, FOLFIRI, and XELOX regimens. Since these regimens resulted in progressive disease, regorafenib was started as the fourth regimen. After 8 courses, she was evaluated as having a partial response. Her partial response has continued for 18 months of regorafenib treatment...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133306/-effectiveness-of-irinotecan-s-1-and-bevacizumab-for-rectal-cancer-with-lung-and-skin-metastases-after-adjuvant-chemotherapy
#8
Kiyotaka Hagihara, Masataka Ikeda, Sakae Maeda, Mamoru Uemura, Kazuyoshi Yamamoto, Masakazu Miyake, Naoki Hama, Kazuhiro Nishikawa, Atsushi Miyamoto, Hideyasu Omiya, Michihiko Miyazaki, Motohiro Hirao, Koji Takami, Shoji Nakamori, Mitsugu Sekimoto
A 50-year-old woman with a chief complaint of bloody stools was diagnosed with rectal cancer via colonoscopy. Laparoscopic rectal anterior resection with D3 lymph node dissection was performed in June 2014. The pathological diagnosis was pStage III a(Ra, pT3, N1)cancer, and the patient received 8 courses of XELOX as postoperative adjuvant chemotherapy. During follow-up at 12 months after surgery, chest computed tomography revealed a mass in the left lingular segment measuring 25mm in diameter and multiple small nodules in both the lungs, indicating lung metastases...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133295/-a-systematic-analysis-of-oncogene-and-tumor-suppressor-genes-for-panitumumab-resistant-rectal-cancer-with-wild-ras-gene-a-case-report
#9
Yosuke Tajima, Yoshifumi Shimada, Ryoma Yagi, Takuma Okamura, Masato Nakano, Hitoshi Kameyama, Hitoshi Nogami, Satoshi Maruyama, Yasumasa Takii, Kohei Miura, Hiroshi Ichikawa, Masayuki Nagahashi, Jun Sakata, Takashi Kobayashi, Toshifumi Wakai
A 58-year-old man was admitted with the complaint of bloody stools. Colonoscopy and computed tomography revealed a rectal cancer with a liver metastasis and multiple lung metastases. After administering a regimen comprising 3 courses of XELOX plus bevacizumab chemotherapy, the sizes of the primary and metastatic lesions decreased remarkably. Abdominoperineal resection was performed for local control of the cancer; the specimen from the initial tumor was found to be KRAS wild type. After 14 courses of XELOX chemotherapy, brain metastases were detected...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133255/-a-case-report-of-clinical-complete-response-with-chemotherapy-for-descending-colon-cancer-complicated-with-severe-pulmonary-dysfunction
#10
Hidehiko Uno, Takashi Shida, Takeshi Ogasawara, Satoru Nomura, Yoshihiro Takahara, Yoshiharu Sato, Teisuke Komatu, Makoto Takahashi
A 76-year-old male patient was diagnosed with progressive descending colon cancer. Since the patient had severe respiratoryfunction impairment after right pneumonectomy, the anesthesiologydepartment of our hospital determined that general anesthesia induction was too difficult. He was thus started on capecitabine plus oxaliplatin(XELOX)therapy. Three months after starting this treatment, colonoscopyshowed that the site had become scarred, and tissue examination revealed no indication of malignancy. Accordingly, the patient achieved clinical complete response...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133252/-a-case-of-locally-far-advanced-colon-cancer-resected-by-laparoscopic-surgery-after-colonic-stent-insertion-and-neoadjuvant-chemotherapy
#11
Yasushi Ishii, Yosuke Hirano, Taro Munechika, Keita Tanaka, Yoshihiro Yonemitsu, Masako Nomi, Ryosuke Shibata, Tatsuya Okamoto, Hiroshi Maeno, Jun Yanagisawa, Shunji Kawamoto, Tomoaki Noritomi
We report a case of locally far-advanced colon cancer resected by laparoscopic surgery after colonic stent insertion and neoadjuvant chemotherapy. A 71-year-old man with obstructive symptoms was admitted to our hospital in July 2015. CT revealed a sigmoid colon tumor infiltrating the retroperitoneum and small intestine. Lower gastrointestinal endoscopy showed a sigmoid colon cancer. Self-expandable metallic stent insertion for obstructive colon cancer alleviated the patient's symptoms quickly. Four courses of neoadjuvant chemotherapy(XELOX)reduced the primary tumor in size, allowing for laparoscopic surgical resection...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133250/-a-successful-case-of-conversion-therapy-after-chemotherapy-for-advanced-rectal-cancer-with-inguinal-lymph-node-metastasis
#12
Jun Sato, Hideaki Karasawa, Shimpei Maeda, Shinobu Ohnuma, Kazuhiro Watanabe, Munenori Nagao, Tomoya Abe, Hiroaki Musha, Fuyuhiko Motoi, Takeshi Naitoh, Michiaki Unno
A70-year-old man was diagnosed with lower rectal cancer with right inguinal lymph node metastasis. Surgical resection was not suitable for this patient. Chemotherapy(IRIS plus bevacizumab followed by XELOX plus bevacizumab)was administered for 16 months. After the chemotherapy, the rectal tumor and lymph node swelling were significantly reduced and distant metastasis was not observed on CT scans. Therefore, the tumor was considered to be resectable and abdominoperineal resection of the rectum with lymph node dissection was performed...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133248/-a-case-of-long-term-survival-after-repeated-peritoneal-recurrences-of-perforated-sigmoid-colon-cancer-treated-with-systemic-chemotherapy-and-r0-resection-of-peritoneal-tumors
#13
Takaoki Watanabe, Takashi Kobayashi, Atsuhiro Wakai, Ryoma Yagi, Kana Tanaka, Kohei Miura, Yosuke Tajima, Masayuki Nagahashi, Yoshifumi Shimada, Jun Sakata, Hitoshi Kameyama, Takashi Kobayashi, Toshifumi Wakai
We report here a case of long-term survival with repeated peritoneal recurrences after resection of perforated sigmoid colon cancer. A 65-year-old man presented with diarrhea and abdominal pain. Computed tomography(CT)revealed diffuse peritonitis caused by perforated sigmoid colon cancer. We performed sigmoidectomy with D2 lymphadenectomy and descending colostomy. Postoperatively, S-1 was administered for 12 months as adjuvant chemotherapy. CT showed peritoneal nodules 56 months after the surgery. After 10 courses of mFOLFOX6 plus bevacizumab, the tumors decreased in size (reduction rate of 34...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133152/-a-case-of-small-bowel-adenocarcinoma-that-was-diagnosed-and-treated-using-laparoscopic-surgery
#14
Junya Kondo, Yoshinari Maeda, Taku Nisimura, Yukiko Nagashima, Atsushi Nagashima, Katsuhiko Morita, Mihoko Setoguchi, Kouichiro Sakata
A 40-year-old man presented to our department with chief complaints of nausea and abdominal pain, and was diagnosed with small intestine ileus. After hospitalization, he underwent intestinal tract decompression using an ileus tube. A small bowel tumor was suspected as the cause of the intestinal obstruction. We then performed laparoscopic surgery for diagnosis and resection. In the intraoperative findings, stenosis near the small intestine tumor could be confirmed. The patient therefore underwent laparoscopic resection of a segment of the small intestine...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133141/-a-case-of-aortoesophageal-fistula-rupture-due-to-descending-thoracic-aortic-dissection-with-recurrent-colon-cancer-during-chemotherapy-containing-bevacizumab
#15
Takamaru Koda, Junichi Koike, Hiroshi Masuhara, Akiharu Kurihara, Hiroyuki Shiokawa, Mitsunori Ushigome, Tomoaki Kaneko, Takayuki Suzuki, Yuko Sawaguchi, Tomoyuki Katayanagi, Takerou Fujii, Yoshinori Watanabe, Kimihiko Funahashi, Hideaki Shimada, Hironori Kaneko
We report a case of aortoesophageal fistula rupture during the course of chemotherapy following colon cancer resection. The patient was a 77-year-old woman. Following recurrence of cancer of the sigmoid colon, the patient received a course of XELOX plus bevacizumab(Bmab)to treat peritoneal dissemination and lung metastases. She was brought by ambulance to our hospital's emergency department 55 days after the last dose of Bmab, with a chief complaint of hematemesis. Hematolo- gy results showed severe anemia with a hemoglobin level of 4...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133137/-recurrence-of-jejunal-carcinoma-in-the-ileum-and-ovary-a-case-report
#16
Nobuyoshi Ohara, Naotsugu Haraguchi, Toshihiro Kudo, Hidekazu Takahashi, Junichi Nishimura, Taishi Hata, Chu Matsuda, Taroh Satoh, Tsunekazu Mizushima, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori
Small bowel carcinoma has poor prognosis. The basis of treatment is surgical resection. There are no established guidelines for chemotherapy. We report a case in which we performed surgical resection of recurrent jejunal carcinoma. A 62-year-old woman underwent laparoscopic partial resection of the small intestine for primary jejunal carcinoma. The final diagnosis was T3N0M0, fStage II A. After 16 months of follow-up, she developed abdominal pain and vomiting. We diagnosed recurrence of jejunal carcinoma in the ileum and right ovary...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133117/-pathological-complete-response-in-a-case-of-multiple-liver-metastases-from-rectal-cancer-treated-with-xelox-plus-bevacizumab-bev-therapy
#17
Shingo Noura, Takashi Shuto, Arisa Muratsu, Yuta Yoshida, Akinobu Yasuyama, Tae Matsumura, Chikato Koga, Chizu Kameda, Masahiro Murakami, Ryohei Kawabata, Masaki Hirota, Masato Yoshikawa, Junzo Shimizu, Junichi Hasegawa, Hideaki Miwa
The patient was a 56-year-old woman who had synchronous multiple liver metastases and underwent laparoscopic-assisted high anterior resection for rectal cancer. According to the Japanese classification of colorectal carcinoma(8th edition), the tumor was considered to be pStage IV (pT4bN2M1a[H3]). Following resection of the primary tumor, she received XELOX plus bevacizumab(Bev)therapy. After 5 courses, the tumors were markedly reduced in size. According to the RECIST criteria, the tumor response was determined to be a partial response(-44%)...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133111/-unresectable-stage-iv-sigmoid-colon-cancer-with-extended-resection-for-primary-tumor-a-case-report
#18
Yuta Kimura, Nobuaki Suzuki, Shinobu Tomochika, Yuka Inoue, Hironori Tanaka, Yoshihiro Tokuhisa, Michihisa Iida, Kazuhiko Sakamoto, Shigeru Takeda, Tomio Ueno, Shigeru Yamamoto, Shigefumi Yoshino, Shoichi Hazama, Hiroaki Nagano
A 65-year-old woman who was diagnosed with unresectable Stage IV sigmoid colon cancer underwent transverse colostomy with double orifices. Although KRAS gene mutation was observed, we could not administer bevacizumab because of the risk of bleeding from the primary tumor and peritumoral abscess. We started bi-weekly XELOX therapy but bloody bowel discharge continued. We planned extended resection of the primary tumor in order to control the bleeding and perforation. Sigmoidectomy, partial resection of the left ureter and small intestine, partial hysterectomy, bilateral salpingo-oophorectomy, and umbilical tumor resection were performed and the patient was discharged on the 10th day after surgery...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28119041/a-multi-center-open-label-randomized-phase-iii-trial-of-first-line-chemotherapy-with-capecitabine-monotherapy-versus-capecitabine-plus-oxaliplatin-in-elderly-patients-with-advanced-gastric-cancer
#19
In Gyu Hwang, Jun Ho Ji, Jung Hun Kang, Hyo Rak Lee, Hui-Young Lee, Kyong-Choun Chi, Suk Won Park, Su Jin Lee, Seung Tae Kim, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang
OBJECTIVES: More than half of cases of gastric cancer (GC) are diagnosed in elderly patients (≥70years). While doublet combination with fluoropyrimidines and platinum is currently considered standard first-line chemotherapy in advanced GC, the main goal of chemotherapy remains palliation. MATERIALS AND METHODS: In a multi-center phase III trial, patients with chemotherapy-naïve, metastatic GC, aged 70years or older were randomized 1:1 to receive X monotherapy (capecitabine 1000mg/m(2) bid po on days one to fourteen) or XELOX (X plus oxaliplatin 110mg/m(2) iv on D1)...
January 21, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28007025/study-protocol-of-the-asian-xeliri-project-axept-a-multinational-randomized-non-inferiority-phase-iii-trial-of-second-line-chemotherapy-for-metastatic-colorectal-cancer-comparing-the-efficacy-and-safety-of-xeliri-with-or-without-bevacizumab-versus-folfiri-with
#20
RANDOMIZED CONTROLLED TRIAL
Masahito Kotaka, Ruihua Xu, Kei Muro, Young Suk Park, Satoshi Morita, Satoru Iwasa, Hiroyuki Uetake, Tomohiro Nishina, Hiroaki Nozawa, Hiroshi Matsumoto, Kentaro Yamazaki, Sae-Won Han, Wei Wang, Joong Bae Ahn, Yanhong Deng, Sang-Hee Cho, Yi Ba, Keun-Wook Lee, Tao Zhang, Taroh Satoh, Marc E Buyse, Baek-Yeol Ryoo, Lin Shen, Junichi Sakamoto, Tae Won Kim
BACKGROUND: Capecitabine and irinotecan combination therapy (XELIRI) has been examined at various dose levels to treat metastatic colorectal cancer (mCRC). Recently, in the Association of Medical Oncology of the German Cancer Society (AIO) 0604 trial, tri-weekly XELIRI plus bevacizumab, with reduced doses of irinotecan (200 mg/m(2) on day 1) and capecitabine (1600 mg/m(2) on days 1-14), repeated every 3 weeks, has shown favorable tolerability and efficacy which were comparable to those of capecitabine and oxaliplatin (XELOX) plus bevacizumab...
December 22, 2016: Chinese Journal of Cancer
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