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Smile design

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https://www.readbyqxmd.com/read/29668813/factors-influencing-the-impact-of-oral-health-on-the-daily-activities-of-adolescents-adults-and-older-adults
#1
Jaqueline Vilela Bulgareli, Eduardo Tanajura de Faria, Karine Laura Cortellazzi, Luciane Miranda Guerra, Marcelo de Castro Meneghim, Glaucia Maria Bovi Ambrosano, Antonio Carlos Frias, Antonio Carlos Pereira
OBJECTIVE: Analyze if clinical, sociodemographic and access to dental services variables influence the impact of oral health on the daily activities of adolescents, adults and older adults. METHODS: A cross-sectional study with secondary data from the State Oral Health Survey (SB São Paulo 2015) conducted in 163 cities of São Paulo. A total of 17,560 individuals from three age groups: 15-19-year-old (n = 5,558), 35-44-year-old (n = 6,051), and older people of 65 years or more (n = 5,951) participated in the survey...
2018: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29657085/structural-determinants-for-small-molecule-activation-of-skeletal-muscle-ampk-%C3%AE-2%C3%AE-2%C3%AE-1-by-the-glucose-importagog-sc4
#2
Kevin R W Ngoei, Christopher G Langendorf, Naomi X Y Ling, Ashfaqul Hoque, Swapna Johnson, Michelle C Camerino, Scott R Walker, Ylva E Bozikis, Toby A Dite, Ashley J Ovens, William J Smiles, Roxane Jacobs, He Huang, Michael W Parker, John W Scott, Mark H Rider, Richard C Foitzik, Bruce E Kemp, Jonathan B Baell, Jonathan S Oakhill
The AMP-activated protein kinase (AMPK) αβγ heterotrimer regulates cellular energy homeostasis with tissue-specific isoform distribution. Small-molecule activation of skeletal muscle α2β2 AMPK complexes may prove a valuable treatment strategy for type 2 diabetes and insulin resistance. Herein, we report the small-molecule SC4 is a potent, direct AMPK activator that preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake. In parallel with the term secretagog, we propose "importagog" to define a substance that induces or augments cellular uptake of another substance...
April 7, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29655527/the-smiling-scan-technique-facially-driven-guided-surgery-and-prosthetics
#3
Alessandro Pozzi, Lorenzo Arcuri, Peter K Moy
PURPOSE: To introduce a proof of concept technique and new integrated workflow to optimize the functional and esthetic outcome of the implant-supported restorations by means of a 3-dimensional (3D) facially-driven, digital assisted treatment plan. METHODS: The Smiling Scan technique permits the creation of a virtual dental patient (VDP) showing a broad smile under static conditions. The patient is exposed to a cone beam computed tomography scan (CBCT), displaying a broad smile for the duration of the examination...
April 11, 2018: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/29599590/correlation-between-dentofacial-esthetics-and-mental-temperament-a-clinical-photographic-analysis-using-visagism
#4
Tanikonda Rambabu, Chava Gayatri, Girija S Sajjan, P Venkata Karteek Varma, Visinigiri Srikanth
Background: "Visagism," a proposed novel concept, makes it possible for the patients to express the desirable emotions and personality traits, through their smile. According to this concept, clinicians can design a smile that blends with the patient's physical appearance, personality, and desires. Aim: To establish a relation, if any, between the smile pattern (dentofacial esthetics determined by three parameters, i.e., tooth form, long axes of maxillary anterior teeth, and connection line between embrasure) and the personality traits (four mental temperaments) through the concept of visagism...
January 2018: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29569445/adversarial-threshold-neural-computer-for-molecular-de-novo-design
#5
Evgeny Putin, Arip Asadulaev, Quentin Vanhaelen, Yan Ivanenkov, Anastasiya Aladinskaya, Alex Aliper, Alex Zhavoronkov
In this paper, we propose the deep neural network Adversarial Threshold Neural Computer (ATNC). The ATNC model is intended for the de novo design of novel small-molecule organic structures. The model is based on generative adversarial net- work architecture and reinforcement learning. ATNC uses a Differentiable Neural Com- puter as a generator and has a new specific block, called adversarial threshold (AT). AT acts as a filter between the agent (generator) and the environment (discriminator + objective reward functions)...
March 23, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29566121/the-multivector-gracilis-free-functional-muscle-flap-for-facial-reanimation
#6
Kofi O Boahene, James Owusu, Lisa Ishii, Masaru Ishii, Shaun Desai, Irene Kim, Leslie Kim, Patrick Byrne
Importance: A multivector functional muscle flap that closely simulates the biomechanical effects of facial muscle groups is essential for complete smile restoration after facial paralysis. Objective: To determine the feasibility of a multivector gracilis muscle flap design for reanimation after facial paralysis and to analyze the effect on the smile display zone. Design, Setting, and Participants: Prospective analysis of patients who underwent a double paddle multivector gracilis flap for complete facial paralysis between June 2015 and December 2016 was carried out in a tertiary hospital...
March 22, 2018: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29528674/investigating-the-social-costs-of-schizophrenia-facial-expressions-in-dyadic-interactions-of-people-with-and-without-schizophrenia
#7
Marcel Riehle, Tania M Lincoln
People with schizophrenia show marked reductions in their emotional expressiveness, generally known as blunted affect. In this study, we tested whether interaction partners would evaluate community-dwelling participants with schizophrenia less favorably than healthy controls and whether this difference would be explained by reduced smiling behavior related to schizophrenia. We also tested whether deficient affect recognition would predict reduced smiling. We created 3 study groups, consisting of 28 participants each, participants with schizophrenia (SZ), healthy controls (HC), and naive healthy interaction partners (IP)...
February 2018: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29493251/ten-steps-to-create-virtual-smile-design-templates-with-adobe-photoshop%C3%A2-cs6
#8
Manoj Kumar Sundar, Venkataraman Chelliah
Computer design software has become a primary tool for communication among the dentist, patient, and ceramist. Virtual smile design can be carried out using various software programs, most of which use assorted forms of teeth templates that are made based on the concept of "golden proportion." Despite current advances in 3-dimensional imaging and smile designing, many clinicians still employ conventional design methods and analog (ie, man-made) mock-ups in assessing and establishing esthetic makeovers...
March 2018: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/29432422/topicalpdb-a-database-of-topically-delivered-peptides
#9
Deepika Mathur, Ayesha Mehta, Priyanka Firmal, Gursimran Bedi, Charu Sood, Ankur Gautam, Gajendra P S Raghava
TopicalPdb (http://crdd.osdd.net/raghava/topicalpdb/) is a repository of experimentally verified topically delivered peptides. Data was manually collected from research articles. The current release of TopicalPdb consists of 657 entries, which includes peptides delivered through the skin (462 entries), eye (173 entries), and nose (22 entries). Each entry provides comprehensive information related to these peptides like the source of origin, nature of peptide, length, N- and C-terminal modifications, mechanism of penetration, type of assays, cargo and biological properties of peptides, etc...
2018: PloS One
https://www.readbyqxmd.com/read/29429287/-observational-study-on-the-impact-of-corneal-power-on-refractive-status-of-patients-after-small-incision-lenticule-extraction-surgery
#10
T Liu, T Yu, J Pan, Y C Zou, L N Liu, Q X Kan, J Bai
Objective: To observe the change of refractive status and possible influencing factors for patients with different corneal power who underwent small incision lenticule extraction (SMILE) surgery. Methods: Prospective cohort study was performed for patients who underwent small incision lenticule extraction (SMILE) surgery at Daping Hospital and Research Institute of Surgery of Third Military Medical University between January and August 2016. The patients were divided into 3 groups according to their corneal power: low curvature group (K(1)≤41...
January 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29429283/-advantages-and-disadvantages-of-femtosecond-laser-assisted-lasik-and-smile
#11
F J Zhang, M S Sun
With the development of excimer laser and femtosecond laser equipment, application of diversified and customized surgical decision in modern corneal refractive surgery has been an inevitable trend. However, how to make a personalized decision with an accurate surgical design to achieve better visual quality becomes the main focus in clinical applications. Small-incision lenticule extraction (SMILE) and femtosecond assisted laser in situ keratomileusis (FS-LASIK) have been commonly acknowledged as the mainstream of corneal refractive surgery for ametropia correction nowadays...
January 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29423522/societal-identification-of-facial-paralysis-and-paralysis-location
#12
Peiyi Su, Lisa E Ishii, Jason Nellis, Jacob Dey, Kristin L Bater, Patrick J Byrne, Kofi D O Boahene, Masaru Ishii
Importance: When able to identify facial paralysis, members of society regard individuals with facial paralysis differently. They perceive a decrease in attractiveness, more negative affect, and lower quality of life. However, the ability of lay people in society to accurately identify the presence of facial paralysis has not yet been defined. Objective: To determine societal members' ability to (1) identify paralysis in varying degrees of paralysis severity and (2) localize the defect on the face...
February 8, 2018: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29417573/smile-aesthetics-satisfaction-scale-development-and-validation-of-a-new-brief-five-item-measure-of-satisfaction-with-smile-aesthetics-in-adults-and-the-elderly
#13
Vlatka Lajnert, Daniela Kovacevic Pavicic, Andrej Pavlic, Alessandra Pokrajac-Bulian, Stjepan Spalj
OBJECTIVE: To create and validate a brief questionnaire designed for the assessment of satisfaction with smile aesthetics and to test its efficiency as a patient-centred outcome measure of aesthetic interventions in dentistry. MATERIALS AND METHODS: A team of three specialists - two from prosthodontics and one psychologist - used a self-evaluation scale consisting of five elements in order to rate self-perceived smile aesthetics. A total of 671 subjects (63% female), 18-86 years of age, were included in the investigation...
February 7, 2018: International Dental Journal
https://www.readbyqxmd.com/read/29391503/a-wearable-high-resolution-facial-electromyography-for-long-term-recordings-in-freely-behaving-humans
#14
Lilah Inzelberg, David Rand, Stanislav Steinberg, Moshe David-Pur, Yael Hanein
Human facial expressions are a complex capacity, carrying important psychological and neurological information. Facial expressions typically involve the co-activation of several muscles; they vary between individuals, between voluntary versus spontaneous expressions, and depend strongly on personal interpretation. Accordingly, while high-resolution recording of muscle activation in a non-laboratory setting offers exciting opportunities, it remains a major challenge. This paper describes a wearable and non-invasive method for objective mapping of facial muscle activation and demonstrates its application in a natural setting...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29380471/management-of-challenging-esthetic-anterior-cases-with-limited-restorative-space-a-clinical-report
#15
Ahmed Afify, Stephan Haney
With careful restorative planning and surgical placement, dental implants can be used to support and retain a wide range of esthetic prostheses. When implant planning or surgical executions are less than ideal, however, the resulting restorative space can be a significant obstacle to successful treatment. The aim of this article is to describe the use of a customized anterior bar to support a partial overdenture prosthesis for a youthful patient with a high smile line and a limited restorative space of 6 mm...
January 29, 2018: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29343468/onabotulinum-toxin-a-injections-for-sleep-bruxism-a-double-blind-placebo-controlled-study
#16
William G Ondo, Jerald H Simmons, Muhammad H Shahid, Vera Hashem, Christine Hunter, Joseph Jankovic
OBJECTIVES: To test the safety and efficacy of onabotulinum toxin-A (BoNT-A) injections into the masseter and temporalis muscles in patients with symptomatic sleep bruxism. METHODS: Participants 18 to 85 years old with clinically diagnosed sleep bruxism confirmed by polysomnography were enrolled in this randomized, placebo-controlled, 1:1, parallel-design trial with open-label extension. Participants were injected with BoNT-A 200 units (60 into each masseter and 40 into each temporalis) or placebo and were evaluated at 4 to 8 weeks after the initial treatment visit...
February 13, 2018: Neurology
https://www.readbyqxmd.com/read/29334434/the-case-for-stabilized-stannous-fluoride-dentifrice-an-advanced-formulation-designed-for-patient-preference
#17
Tao He, Svetlana Farrell
Oral diseases, particularly caries and gingivitis, continue to be widespread. Incorporating a stabilized stannous fluoride dentifrice into patients' daily oral hygiene routine is a convenient, cost effective approach to improve and protect their oral health and the appearance of their smile. Unlike other common fluorides that only provide anti-caries benefits (e.g., sodium fluoride and sodium monofluorophosphate), stabilized stannous fluoride formulations have demonstrated broader and significantly greater protection, also reducing plaque, gingivitis, erosion, sensitivity, and halitosis...
December 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29332601/quantitative-structure-activity-relationship-study-of-betulinic-acid-derivatives-against-hiv-using-smiles-based-descriptors
#18
Apilak Worachartcheewan, Alla P Toropova, Andrey A Toropov, Suphakit Siriwong, Jatupat Prapojanasomboon, Virapong Prachayasittikul, Chanin Nanatasenamat
BACKGROUND: Human immunodeficiency virus (HIV) is the causative agent of acquired immunodeficiency syndrome (AIDS) that imposes a global health burden. Therefore, HIV therapeutic agents have been discovery and development. OBJECTIVE: To construct quantitative-structure activity relationship (QSAR) models of betulinic acid derivatives with anti-HIV activity using simplified molecular-input line-entry system (SMILES)-based descriptors Methods: A data set of 107 betulinic acid derivatives and their anti-HIV activity was used to develop QSAR models...
January 11, 2018: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/29319225/de-novo-design-of-bioactive-small-molecules-by-artificial-intelligence
#19
Daniel Merk, Lukas Friedrich, Francesca Grisoni, Gisbert Schneider
Generative artificial intelligence offers a fresh view on molecular design. We present the first-time prospective application of a deep learning model for designing new druglike compounds with desired activities. For this purpose, we trained a recurrent neural network to capture the constitution of a large set of known bioactive compounds represented as SMILES strings. By transfer learning, this general model was fine-tuned on recognizing retinoid X and peroxisome proliferator-activated receptor agonists. We synthesized five top-ranking compounds designed by the generative model...
January 2018: Molecular Informatics
https://www.readbyqxmd.com/read/29301376/sistematx-an-online-web-based-cheminformatics-tool-for-data-management-of-secondary-metabolites
#20
Marcus Tullius Scotti, Chonny Herrera-Acevedo, Tiago Branquinho Oliveira, Renan Paiva Oliveira Costa, Silas Yudi Konno de Oliveira Santos, Ricardo Pereira Rodrigues, Luciana Scotti, Fernando Batista Da-Costa
The traditional work of a natural products researcher consists in large part of time-consuming experimental work, collecting biota to prepare and analyze extracts and to identify innovative metabolites. However, along this long scientific path, much information is lost or restricted to a specific niche. The large amounts of data already produced and the science of metabolomics reveal new questions: Are these compounds known or new? How fast can this information be obtained? To answer these and other relevant questions, an appropriate procedure to correctly store information on the data retrieved from the discovered metabolites is necessary...
January 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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